| Friday, January 4 |
| Future White Sox Daryl Boston is born in Cincinnati, OH. |
| Saturday, January 5 |
| Future White Sox John Davis is born in Chicago, IL. |
| Thursday, January 31 |
| Future White Sox Dave Cochrane is born in Riverside, CA. |
| Sunday, February 10 |
| Future White Sox Dane Johnson is born in Coral Gables, FL. |
| Friday, February 15 |
| Future White Sox Barry Jones is born in Centerville, IN. Former White Sox Bump Hadley dies in Lynn, MA at the age of 59. |
| Saturday, February 23 |
| Future White Sox Bobby Bonilla is born in Bronx, NY. |
| Monday, February 25 |
| Future White Sox Joel McKeon is born in Covington, KY. |
| Friday, March 1 |
| Future White Sox Tony Castillo is born in Quibor, Venezuela. |
| Sunday, March 10 |
| Future White Sox John Cangelosi is born in Brooklyn, NY. |
| Monday, April 8 |
| » Major-league debuts: Tom Brown (Senators) |
| Tuesday, April 9 |
| » Defeated Tigers (0-1), 7-5 | Tiger Stadium (1-0) | 1-0 | |
| » Starters: Ray Herbert vs Jim Bunning | First | -- |
| » Major-league debuts: Dick Egan (Tigers) |
| Wednesday, April 10 |
| » Lost to Tigers (1-1), 2-1 | Tiger Stadium (1-1) | 1-1 | |
| » Starters: Eddie Fisher vs Hank Aguirre | Second | 1 out |
| Future White Sox Mike Devereaux is born in Casper, WY. Future White Sox Marvin Freeman is born in Chicago, IL. |
| Thursday, April 11 |
| » Defeated Angels (1-2), 3-1 | Dodger Stadium (1-0) | 2-1 | |
| » Starters: Joe Horlen vs Bo Belinsky | Second | 1 out |
| Saturday, April 13 |
| » Lost to Angels (2-2), 1-0 | Dodger Stadium (1-1) | 2-2 | |
| » Starters: Juan Pizarro vs Ken McBride | Second | 1 out |
| Tuesday, April 16 |
| » Lost to Athletics (4-2), 7-4 | Comiskey Park I (0-1) | 2-3 | Lost 2 |
| » Starters: Ted Bowsfield vs Eddie Fisher | Third | 1½ out |
| Thursday, April 18 |
| » Defeated Athletics (4-3), 3-0 | Comiskey Park I (1-1) | 3-3 | |
| » Starters: Ed Rakow vs Ray Herbert | Third | 1½ out |
| Friday, April 19 |
| » Defeated Twins (3-6), 3-1 | Comiskey Park I (2-1) | 4-3 | Won 2 |
| » Starters: Camilo Pascual vs Juan Pizarro | Third | 1 out |
| Saturday, April 20 |
| » Defeated Twins (3-7), 10-7 | Comiskey Park I (3-1) | 5-3 | Won 3 |
| » Starters: Jim Kaat vs Joe Horlen | Second | ½ out |
| » Major-league debuts: Garry Roggenburk (Twins) |
| Sunday, April 21 |
| » Lost to Twins (4-7), 7-0 | Comiskey Park I (3-2) | 5-4 | |
| » Starters: Jim Roland vs Eddie Fisher | Second | ½ out |
| » Defeated Twins (4-8), 8-0 | Comiskey Park I (4-2) | 6-4 | |
| » Starters: Jack Kralick vs John Buzhardt | Second | ½ out |
| Wednesday, April 24 |
| » Defeated Yankees (6-5), 6-4 | Yankee Stadium (1-0) | 7-4 | Won 2 |
| » Starters: Juan Pizarro vs Stan Williams | Second | 1½ out |
| Saturday, April 27 |
| » Lost to Red Sox (7-6), 9-5 | Fenway Park (0-1) | 7-5 | |
| » Starters: Ray Herbert vs Gene Conley | Third | 2 out |
| Sunday, April 28 |
| » Lost to Red Sox (8-6), 4-3 | Fenway Park (0-2) | 7-6 | Lost 2 |
| » Starters: John Buzhardt vs Ike Delock | Fifth | 2½ out |
| » Lost to Red Sox (9-6), 6-2 | Fenway Park (0-3) | 7-7 | Lost 3 |
| » Starters: Eddie Fisher vs Bill Monbouquette | Fifth | 2½ out |
| Wednesday, May 1 |
| » Defeated Orioles (10-9), 7-0 | Comiskey Park I (5-2) | 8-7 | |
| » Starters: Mike McCormick vs Ray Herbert | Third | 2 out |
| » Defeated Orioles (10-10), 6-4 | Comiskey Park I (6-2) | 9-7 | Won 2 |
| » Starters: Robin Roberts vs Joe Horlen | Third | 2 out |
| Thursday, May 2 |
| » Lost to Orioles (11-10), 8-7 | Comiskey Park I (6-3) | 9-8 | |
| » Starters: Dave McNally vs Juan Pizarro | Fourth | 1½ out |
| Friday, May 3 |
| » Lost to Senators (9-13), 5-2 | Comiskey Park I (6-4) | 9-9 | Lost 2 |
| » Starters: Don Rudolph vs John Buzhardt | Fourth | 3 out |
| Saturday, May 4 |
| » Defeated Senators (9-14), 8-1 | Comiskey Park I (7-4) | 10-9 | |
| » Starters: Dave Stenhouse vs Eddie Fisher | Fifth | 3 out |
| Former White Sox Dickey Kerr dies in Houston, TX at the age of 70. |
| Sunday, May 5 |
| » Defeated Senators (9-15), 8-0 | Comiskey Park I (8-4) | 11-9 | Won 2 |
| » Starters: Tom Cheney vs Ray Herbert | Fourth | 2½ out |
| » Lost to Senators (10-15), 8-7 | Comiskey Park I (8-5) | 11-10 | |
| » Starters: Art Quirk vs Joe Horlen | Fourth | 2½ out |
| Monday, May 6 |
| » Defeated Athletics (15-10), 5-1 | Municipal Stadium (1-0) | 12-10 | |
| » Starters: Gary Peters vs Ted Bowsfield | Fourth | 1½ out |
| Tuesday, May 7 |
| » Defeated Athletics (15-11), 2-1 | Municipal Stadium (2-0) | 13-10 | Won 2 |
| » Starters: John Buzhardt vs Dave Wickersham | Fourth | 1½ out |
| Wednesday, May 8 |
| » Defeated Athletics (15-12), 8-3 | Municipal Stadium (3-0) | 14-10 | Won 3 |
| » Starters: Eddie Fisher vs Ed Rakow | First | -- |
| Thursday, May 9 |
| » Defeated Yankees (12-11), 2-0 | Comiskey Park I (9-5) | 15-10 | Won 4 |
| » Starters: Ralph Terry vs Ray Herbert | First | -- |
| Friday, May 10 |
| » Defeated Angels (15-15), 2-0 | Comiskey Park I (10-5) | 16-10 | Won 5 |
| » Starters: Ken McBride vs Juan Pizarro | First | -- |
| Saturday, May 11 |
| » Defeated Angels (15-16), 4-2 | Comiskey Park I (11-5) | 17-10 | Won 6 |
| » Starters: Bo Belinsky vs Gary Peters | First | -- |
| Sunday, May 12 |
| » Defeated Angels (15-17), 14-2 | Comiskey Park I (12-5) | 18-10 | Won 7 |
| » Starters: Dean Chance vs John Buzhardt | First | -- |
| » Lost to Angels (16-17), 7-6 | Comiskey Park I (12-6) | 18-11 | |
| » Starters: Bob Turley vs Joe Horlen | First | -- |
| Monday, May 13 |
| » Lost to Angels (17-17), 7-3 | Comiskey Park I (12-7) | 18-12 | Lost 2 |
| » Starters: Don Lee vs Eddie Fisher | First | -- |
| Tuesday, May 14 |
| » Defeated Tigers (12-18), 3-0 | Comiskey Park I (13-7) | 19-12 | |
| » Starters: Jim Bunning vs Ray Herbert | First | -- |
| Wednesday, May 15 |
| » Defeated Tigers (12-19), 7-4 | Comiskey Park I (14-7) | 20-12 | Won 2 |
| » Starters: Phil Regan vs Juan Pizarro | First | -- |
| Thursday, May 16 |
| » Lost to Indians (14-13), 5-4 | Cleveland Stadium (0-1) | 20-13 | |
| » Starters: John Buzhardt vs Dick Donovan | Second | 2 out |
| Saturday, May 18 |
| » Lost to Orioles (20-14), 2-1 | Memorial Stadium (0-1) | 20-14 | Lost 2 |
| » Starters: Gary Peters vs Steve Barber | Second | 2 out |
| Sunday, May 19 |
| » Lost to Orioles (21-14), 4-3 | Memorial Stadium (0-2) | 20-15 | Lost 3 |
| » Starters: Juan Pizarro vs Robin Roberts | Second | 2 out |
| » Defeated Orioles (21-15), 4-3 | Memorial Stadium (1-2) | 21-15 | |
| » Starters: Ray Herbert vs Mike McCormick | Second | 2 out |
| Monday, May 20 |
| » Defeated Senators (14-25), 5-4 | Robert F. Kennedy Stadium (1-0) | 22-15 | Won 2 |
| » Starters: Eddie Fisher vs Tom Cheney | First | -- |
| Future White Sox David Wells is born in Torrance, CA. |
| Tuesday, May 21 |
| » Defeated Senators (14-26), 4-3 | Robert F. Kennedy Stadium (2-0) | 23-15 | Won 3 |
| » Starters: John Buzhardt vs Don Rudolph | First | -- |
| Wednesday, May 22 |
| » Defeated Senators (14-27), 9-3 | Robert F. Kennedy Stadium (3-0) | 24-15 | Won 4 |
| » Starters: Joe Horlen vs Bennie Daniels | First | -- |
| Thursday, May 23 |
| Former White Sox Gavvy Cravath dies in Laguna Beach, CA at the age of 83. |
| Friday, May 24 |
| » Lost to Twins (18-21), 8-6 | Metropolitan Stadium (0-1) | 24-16 | |
| » Starters: Ray Herbert vs Dick Stigman | Third | 1½ out |
| Saturday, May 25 |
| » Lost to Twins (19-21), 6-0 | Metropolitan Stadium (0-2) | 24-17 | Lost 2 |
| » Starters: Juan Pizarro vs Camilo Pascual | Third | 2½ out |
| Sunday, May 26 |
| » Lost to Twins (20-21), 5-2 | Metropolitan Stadium (0-3) | 24-18 | Lost 3 |
| » Starters: John Buzhardt vs Jim Perry | Third | 4 out |
| Tuesday, May 28 |
| » Lost to Indians (17-21), 3-2 | Comiskey Park I (14-8) | 24-19 | Lost 4 |
| » Starters: Jack Kralick vs Ray Herbert | Third | 5 out |
| Thursday, May 30 |
| » Defeated Indians (17-22), 8-4 | Comiskey Park I (15-8) | 25-19 | |
| » Starters: Sam McDowell vs Juan Pizarro | Third | 3 out |
| » Defeated Indians (17-23), 4-2 | Comiskey Park I (16-8) | 26-19 | Won 2 |
| » Starters: Barry Latman vs Gary Peters | Third | 3 out |
| Friday, May 31 |
| » Defeated Red Sox (22-20), 6-0 | Comiskey Park I (17-8) | 27-19 | Won 3 |
| » Starters: Gene Conley vs John Buzhardt | Third | 2 out |
| Saturday, June 1 |
| » Defeated Red Sox (22-21), 3-1 | Comiskey Park I (18-8) | 28-19 | Won 4 |
| » Starters: Dave Morehead vs Joe Horlen | Third | 3 out |
| Sunday, June 2 |
| » Lost to Red Sox (23-21), 11-9 | Comiskey Park I (18-9) | 28-20 | |
| » Starters: Bill Monbouquette vs Ray Herbert | Third | 3 out |
| » Defeated Red Sox (23-22), 10-0 | Comiskey Park I (19-9) | 29-20 | |
| » Starters: Wilbur Wood vs Juan Pizarro | Third | 3 out |
| Monday, June 3 |
| » Defeated Angels (24-28), 4-0 | Dodger Stadium (2-1) | 30-20 | Won 2 |
| » Starters: Eddie Fisher vs Bob Turley | Second | 3½ out |
| Tuesday, June 4 |
| » Lost to Angels (25-28), 1-0 | Dodger Stadium (2-2) | 30-21 | |
| » Starters: Gary Peters vs Dan Osinski | Third | 1 out |
| » Major-league debuts: Tom McCraw (White Sox) |
| Wednesday, June 5 |
| » Defeated Angels (25-29), 3-0 | Dodger Stadium (3-2) | 31-21 | |
| » Starters: John Buzhardt vs Mel Nelson | Third | 4 out |
| » Lost to Angels (26-29), 8-2 | Dodger Stadium (3-3) | 31-22 | |
| » Starters: Ray Herbert vs Ken McBride | Third | 4 out |
| Friday, June 7 |
| » Defeated Athletics (26-24), 7-1 | Municipal Stadium (4-0) | 32-22 | |
| » Starters: Juan Pizarro vs Dave Wickersham | Second | ½ out |
| Saturday, June 8 |
| » Lost to Athletics (27-24), 7-6 | Municipal Stadium (4-1) | 32-23 | |
| » Starters: Eddie Fisher vs Ted Bowsfield | Second | ½ out |
| Sunday, June 9 |
| » Defeated Athletics (27-25), 4-3 | Municipal Stadium (5-1) | 33-23 | |
| » Starters: Gary Peters vs Ed Rakow | First | -- |
| Tuesday, June 11 |
| » Lost to Twins (29-25), 8-6 | Comiskey Park I (19-10) | 33-24 | |
| » Starters: Dick Stigman vs Ray Herbert | First | -- |
| Wednesday, June 12 |
| » Defeated Angels (28-33), 3-1 | Comiskey Park I (20-10) | 34-24 | |
| » Starters: Don Lee vs John Buzhardt | Second | 3½ out |
| » Lost to Angels (29-33), 5-0 | Comiskey Park I (20-11) | 34-25 | |
| » Starters: Bob Turley vs Juan Pizarro | Second | 3½ out |
| Friday, June 14 |
| » Defeated Athletics (29-29), 3-2 | Comiskey Park I (21-11) | 35-25 | |
| » Starters: Ed Rakow vs Gary Peters | First | -- |
| Saturday, June 15 |
| » Lost to Athletics (30-29), 4-3 | Comiskey Park I (21-12) | 35-26 | |
| » Starters: Diego Segui vs Ray Herbert | Second | 3 out |
| Sunday, June 16 |
| » Defeated Athletics (30-30), 2-1 | Comiskey Park I (22-12) | 36-26 | |
| » Starters: Dave Wickersham vs John Buzhardt | Second | 3 out |
| » Defeated Athletics (30-31), 3-2 | Comiskey Park I (23-12) | 37-26 | Won 2 |
| » Starters: Orlando Pena vs Juan Pizarro | Second | 3 out |
| Monday, June 17 |
| Future White Sox Tom Drees is born in Des Moines, IA. |
| Tuesday, June 18 |
| » Lost to Twins (33-29), 5-3 | Metropolitan Stadium (0-4) | 37-27 | |
| » Starters: Joe Horlen vs Jim Perry | Second | 3 out |
| Wednesday, June 19 |
| » Defeated Twins (33-30), 12-4 | Metropolitan Stadium (1-4) | 38-27 | |
| » Starters: Ray Herbert vs Dick Stigman | Second | 3 out |
| Thursday, June 20 |
| » Lost to Twins (34-30), 9-4 | Metropolitan Stadium (1-5) | 38-28 | |
| » Starters: John Buzhardt vs Jim Kaat | Second | 3 out |
| Friday, June 21 |
| » Defeated Indians (35-29), 2-0 | Cleveland Stadium (1-1) | 39-28 | |
| » Starters: Juan Pizarro vs Early Wynn | Second | 3 out |
| Saturday, June 22 |
| » Defeated Indians (35-30), 2-1 | Cleveland Stadium (2-1) | 40-28 | Won 2 |
| » Starters: Gary Peters vs Mudcat Grant | Second | 2½ out |
| Sunday, June 23 |
| » Defeated Indians (35-31), 2-1 | Cleveland Stadium (3-1) | 41-28 | Won 3 |
| » Starters: Ray Herbert vs Jack Kralick | Second | 3 out |
| » Lost to Indians (36-31), 2-0 | Cleveland Stadium (3-2) | 41-29 | |
| » Starters: Dave DeBusschere vs Barry Latman | Second | 3 out |
| Monday, June 24 |
| » Defeated Yankees (40-25), 5-2 | Comiskey Park I (24-12) | 42-29 | |
| » Starters: Al Downing vs John Buzhardt | Second | 3 out |
| Tuesday, June 25 |
| » Defeated Yankees (40-26), 2-1 | Comiskey Park I (25-12) | 43-29 | Won 2 |
| » Starters: Ralph Terry vs Juan Pizarro | Second | 3 out |
| Wednesday, June 26 |
| » Lost to Yankees (41-26), 3-2 | Comiskey Park I (25-13) | 43-30 | |
| » Starters: Whitey Ford vs Gary Peters | Second | 3 out |
| Thursday, June 27 |
| » Defeated Yankees (41-27), 6-0 | Comiskey Park I (26-13) | 44-30 | |
| » Starters: Jim Bouton vs Ray Herbert | Second | 3 out |
| Friday, June 28 |
| » Lost to Indians (38-35), 4-3 | Comiskey Park I (26-14) | 44-31 | |
| » Starters: Early Wynn vs Dave DeBusschere | Second | 3 out |
| Saturday, June 29 |
| » Lost to Indians (39-35), 5-2 | Comiskey Park I (26-15) | 44-32 | Lost 2 |
| » Starters: Jack Kralick vs John Buzhardt | Second | 3 out |
| Sunday, June 30 |
| » Lost to Indians (40-35), 8-4 | Comiskey Park I (26-16) | 44-33 | Lost 3 |
| » Starters: Dick Donovan vs Juan Pizarro | Second | 3 out |
| » Defeated Indians (40-36), 4-0 | Comiskey Park I (27-16) | 45-33 | |
| » Starters: Mudcat Grant vs Gary Peters | Second | 3 out |
| Tuesday, July 2 |
| » Lost to Yankees (46-28), 3-0 | Yankee Stadium (1-1) | 45-34 | |
| » Starters: Ray Herbert vs Al Downing | Third | 3½ out |
| Wednesday, July 3 |
| » Lost to Yankees (47-28), 5-4 | Yankee Stadium (1-2) | 45-35 | Lost 2 |
| » Starters: John Buzhardt vs Ralph Terry | Third | 4½ out |
| Thursday, July 4 |
| » Lost to Yankees (48-28), 9-1 | Yankee Stadium (1-3) | 45-36 | Lost 3 |
| » Starters: Gary Peters vs Whitey Ford | Second | 4½ out |
| » Defeated Yankees (48-29), 4-2 | Yankee Stadium (2-3) | 46-36 | |
| » Starters: Juan Pizarro vs Bill Stafford | Second | 4½ out |
| Friday, July 5 |
| » Lost to Red Sox (43-36), 8-3 | Fenway Park (0-4) | 46-37 | |
| » Starters: Dave DeBusschere vs Earl Wilson | Third | 4½ out |
| Saturday, July 6 |
| » Lost to Red Sox (44-36), 6-2 | Fenway Park (0-5) | 46-38 | Lost 2 |
| » Starters: Ray Herbert vs Dave Morehead | Fourth | 5½ out |
| Future White Sox Lance Johnson is born in Cincinnati, OH. |
| Sunday, July 7 |
| » Defeated Red Sox (44-37), 4-1 | Fenway Park (1-5) | 47-38 | |
| » Starters: Hoyt Wilhelm vs Jack Lamabe | Second | 5 out |
| Thursday, July 11 |
| » Defeated Tigers (35-48), 6-3 | Comiskey Park I (28-16) | 48-38 | Won 2 |
| » Starters: Hank Aguirre vs Gary Peters | Second | 5 out |
| Friday, July 12 |
| » Lost to Tigers (36-48), 7-6 | Comiskey Park I (28-17) | 48-39 | |
| » Starters: Don Mossi vs Juan Pizarro | Third | 6 out |
| Sunday, July 14 |
| » Lost to Orioles (50-41), 6-3 | Comiskey Park I (28-18) | 48-40 | Lost 2 |
| » Starters: Mike McCormick vs Ray Herbert | Third | 6½ out |
| » Defeated Orioles (50-42), 3-2 | Comiskey Park I (29-18) | 49-40 | |
| » Starters: Dave McNally vs John Buzhardt | Third | 6½ out |
| Monday, July 15 |
| » Defeated Orioles (50-43), 4-0 | Comiskey Park I (30-18) | 50-40 | Won 2 |
| » Starters: Robin Roberts vs Gary Peters | Third | 5½ out |
| Tuesday, July 16 |
| » Lost to Senators (33-58), 3-1 | Comiskey Park I (30-19) | 50-41 | |
| » Starters: Claude Osteen vs Juan Pizarro | Third | 6 out |
| Wednesday, July 17 |
| » Defeated Senators (33-59), 8-2 | Comiskey Park I (31-19) | 51-41 | |
| » Starters: Bennie Daniels vs Dave DeBusschere | Second | 6 out |
| Future White Sox Bobby Thigpen is born in Tallahassee, FL. |
| Saturday, July 20 |
| » Defeated Red Sox (50-42), 3-0 | Comiskey Park I (32-19) | 52-41 | Won 2 |
| » Starters: Earl Wilson vs Gary Peters | Second | 5½ out |
| Sunday, July 21 |
| » Lost to Red Sox (51-42), 3-2 | Comiskey Park I (32-20) | 52-42 | |
| » Starters: Bill Monbouquette vs Juan Pizarro | Second | 7 out |
| Tuesday, July 23 |
| » Lost to Tigers (40-52), 5-1 | Tiger Stadium (1-2) | 52-43 | Lost 2 |
| » Starters: John Buzhardt vs Hank Aguirre | Third | 9 out |
| » Lost to Tigers (41-52), 6-4 | Tiger Stadium (1-3) | 52-44 | Lost 3 |
| » Starters: Dave DeBusschere vs Willie Smith | Third | 9 out |
| Wednesday, July 24 |
| » Defeated Tigers (41-53), 3-1 | Tiger Stadium (2-3) | 53-44 | |
| » Starters: Gary Peters vs Don Mossi | Third | 9 out |
| Thursday, July 25 |
| » Defeated Tigers (41-54), 4-3 | Tiger Stadium (3-3) | 54-44 | Won 2 |
| » Starters: Joe Horlen vs Mickey Lolich | Second | 8 out |
| Friday, July 26 |
| » Lost to Orioles (57-46), 6-0 | Memorial Stadium (1-3) | 54-45 | |
| » Starters: Dave DeBusschere vs Milt Pappas | Third | 9 out |
| Saturday, July 27 |
| » Defeated Orioles (57-47), 5-3 | Memorial Stadium (2-3) | 55-45 | |
| » Starters: Ray Herbert vs Steve Barber | Second | 8½ out |
| » Defeated Orioles (57-48), 10-1 | Memorial Stadium (3-3) | 56-45 | Won 2 |
| » Starters: Juan Pizarro vs Mike McCormick | Second | 8½ out |
| Sunday, July 28 |
| » Defeated Orioles (57-49), 4-1 | Memorial Stadium (4-3) | 57-45 | Won 3 |
| » Starters: Gary Peters vs Dave McNally | Second | 8 out |
| Monday, July 29 |
| » Lost to Senators (37-66), 2-1 | Robert F. Kennedy Stadium (3-1) | 57-46 | |
| » Starters: Joe Horlen vs Steve Ridzik | Second | 8 out |
| Tuesday, July 30 |
| » Defeated Senators (37-67), 5-1 | Robert F. Kennedy Stadium (4-1) | 58-46 | |
| » Starters: Dave DeBusschere vs Don Rudolph | Second | 8 out |
| Wednesday, July 31 |
| » Defeated Senators (37-68), 5-2 | Robert F. Kennedy Stadium (5-1) | 59-46 | Won 2 |
| » Starters: Ray Herbert vs Claude Osteen | Second | 8 out |
| Friday, August 2 |
| » Defeated Angels (53-59), 5-1 | Dodger Stadium (4-3) | 60-46 | Won 3 |
| » Starters: Juan Pizarro vs Dean Chance | Second | 7 out |
| Saturday, August 3 |
| » Lost to Angels (54-59), 6-5 | Dodger Stadium (4-4) | 60-47 | |
| » Starters: Gary Peters vs Ken McBride | Second | 8 out |
| Sunday, August 4 |
| » Defeated Angels (54-60), 8-1 | Dodger Stadium (5-4) | 61-47 | |
| » Starters: Joe Horlen vs Don Lee | Second | 7½ out |
| Tuesday, August 6 |
| » Lost to Athletics (50-59), 4-3 | Municipal Stadium (5-2) | 61-48 | |
| » Starters: Ray Herbert vs Diego Segui | Second | 8 out |
| Wednesday, August 7 |
| » Defeated Athletics (50-60), 7-3 | Municipal Stadium (6-2) | 62-48 | |
| » Starters: Juan Pizarro vs Orlando Pena | Second | 8 out |
| Thursday, August 8 |
| » Defeated Athletics (50-61), 5-3 | Municipal Stadium (7-2) | 63-48 | Won 2 |
| » Starters: Gary Peters vs Dave Wickersham | Second | 8 out |
| Future White Sox Ron Karkovice is born in Union, NJ. |
| Friday, August 9 |
| » Defeated Tigers (49-61), 2-1 | Comiskey Park I (33-20) | 64-48 | Won 3 |
| » Starters: Hank Aguirre vs Joe Horlen | Second | 8½ out |
| » Lost to Tigers (50-61), 3-1 | Comiskey Park I (33-21) | 64-49 | |
| » Starters: Mickey Lolich vs Dave DeBusschere | Second | 8½ out |
| Saturday, August 10 |
| » Defeated Tigers (50-62), 5-1 | Comiskey Park I (34-21) | 65-49 | |
| » Starters: Bill Faul vs Ray Herbert | Second | 8½ out |
| Sunday, August 11 |
| » Lost to Tigers (51-62), 7-2 | Comiskey Park I (34-22) | 65-50 | |
| » Starters: Don Mossi vs Juan Pizarro | Second | 9 out |
| » Defeated Tigers (51-63), 3-2 | Comiskey Park I (35-22) | 66-50 | |
| » Starters: Frank Lary vs Gary Peters | Second | 9 out |
| Future White Sox Mike Huff is born in Honolulu, HI. |
| Tuesday, August 13 |
| » Defeated Indians (57-62), 3-0 | Comiskey Park I (36-22) | 67-50 | Won 2 |
| » Starters: Mudcat Grant vs Dave DeBusschere | Second | 8½ out |
| Wednesday, August 14 |
| » Lost to Indians (58-62), 1-0 | Comiskey Park I (36-23) | 67-51 | |
| » Starters: Dick Donovan vs Ray Herbert | Second | 8 out |
| Friday, August 16 |
| » Lost to Yankees (76-42), 4-2 | Comiskey Park I (36-24) | 67-52 | Lost 2 |
| » Starters: Whitey Ford vs Juan Pizarro | Third | 9½ out |
| Saturday, August 17 |
| » Defeated Yankees (76-43), 2-0 | Comiskey Park I (37-24) | 68-52 | |
| » Starters: Al Downing vs Gary Peters | Second | 8½ out |
| Sunday, August 18 |
| » Lost to Yankees (77-43), 8-2 | Comiskey Park I (37-25) | 68-53 | |
| » Starters: Ralph Terry vs Ray Herbert | Second | 10½ out |
| » Lost to Yankees (78-43), 8-4 | Comiskey Park I (37-26) | 68-54 | Lost 2 |
| » Starters: Jim Bouton vs Joe Horlen | Second | 10½ out |
| Tuesday, August 20 |
| » Defeated Red Sox (59-64), 10-2 | Fenway Park (2-5) | 69-54 | |
| » Starters: Juan Pizarro vs Bob Heffner | Second | 9½ out |
| Wednesday, August 21 |
| » Defeated Red Sox (59-65), 7-1 | Fenway Park (3-5) | 70-54 | Won 2 |
| » Starters: Gary Peters vs Bill Monbouquette | Second | 10 out |
| Thursday, August 22 |
| » Lost to Red Sox (60-65), 11-2 | Fenway Park (3-6) | 70-55 | |
| » Starters: Joe Horlen vs Dave Morehead | Second | 10 out |
| Friday, August 23 |
| » Lost to Yankees (81-45), 7-2 | Yankee Stadium (2-4) | 70-56 | Lost 2 |
| » Starters: Hoyt Wilhelm vs Jim Bouton | Second | 11 out |
| Saturday, August 24 |
| » Lost to Yankees (82-45), 3-0 | Yankee Stadium (2-5) | 70-57 | Lost 3 |
| » Starters: Ray Herbert vs Whitey Ford | Second | 12 out |
| Sunday, August 25 |
| » Lost to Yankees (83-45), 4-0 | Yankee Stadium (2-6) | 70-58 | Lost 4 |
| » Starters: Juan Pizarro vs Al Downing | Third | 12 out |
| » Defeated Yankees (83-46), 2-1 | Yankee Stadium (3-6) | 71-58 | |
| » Starters: Gary Peters vs Stan Williams | Third | 12 out |
| Tuesday, August 27 |
| » Defeated Indians (64-69), 6-1 | Cleveland Stadium (4-2) | 72-58 | Won 2 |
| » Starters: Joe Horlen vs Mudcat Grant | Second | 12½ out |
| Wednesday, August 28 |
| » Defeated Indians (64-70), 8-3 | Cleveland Stadium (5-2) | 73-58 | Won 3 |
| » Starters: Juan Pizarro vs Pedro Ramos | Second | 12 out |
| » Defeated Indians (64-71), 3-1 | Cleveland Stadium (6-2) | 74-58 | Won 4 |
| » Starters: Eddie Fisher vs Dick Donovan | Second | 12 out |
| Thursday, August 29 |
| » Defeated Indians (64-72), 7-2 | Cleveland Stadium (7-2) | 75-58 | Won 5 |
| » Starters: Gary Peters vs Barry Latman | Second | 11 out |
| Friday, August 30 |
| » Lost to Twins (75-58), 5-3 | Metropolitan Stadium (1-6) | 75-59 | |
| » Starters: Ray Herbert vs Camilo Pascual | Third | 12 out |
| Saturday, August 31 |
| » Defeated Twins (75-59), 2-0 | Metropolitan Stadium (2-6) | 76-59 | |
| » Starters: Joe Horlen vs Dick Stigman | Second | 12 out |
| Sunday, September 1 |
| » Defeated Twins (75-60), 8-3 | Metropolitan Stadium (3-6) | 77-59 | Won 2 |
| » Starters: Eddie Fisher vs Jim Kaat | Second | 12 out |
| Monday, September 2 |
| » Lost to Angels (62-77), 7-5 | Comiskey Park I (37-27) | 77-60 | |
| » Starters: Don Lee vs Gary Peters | Second | 12 out |
| » Defeated Angels (62-78), 8-7 | Comiskey Park I (38-27) | 78-60 | |
| » Starters: Ken McBride vs Dave DeBusschere | Second | 12 out |
| Wednesday, September 4 |
| » Lost to Athletics (62-76), 4-2 | Comiskey Park I (38-28) | 78-61 | |
| » Starters: Orlando Pena vs Ray Herbert | Third | 13 out |
| » Lost to Athletics (63-76), 7-3 | Comiskey Park I (38-29) | 78-62 | Lost 2 |
| » Starters: Diego Segui vs Joe Horlen | Third | 13 out |
| » Major-league debuts: Bruce Howard (White Sox) |
| Thursday, September 5 |
| » Defeated Athletics (63-77), 4-1 | Comiskey Park I (39-29) | 79-62 | |
| » Starters: Ed Rakow vs Gary Peters | Second | 13 out |
| Friday, September 6 |
| » Lost to Twins (79-62), 9-8 | Comiskey Park I (39-30) | 79-63 | |
| » Starters: Jim Kaat vs Eddie Fisher | Third | 14 out |
| Saturday, September 7 |
| » Lost to Twins (80-62), 4-2 | Comiskey Park I (39-31) | 79-64 | Lost 2 |
| » Starters: Lee Stange vs Hoyt Wilhelm | Third | 15 out |
| Sunday, September 8 |
| » Defeated Twins (80-63), 5-2 | Comiskey Park I (40-31) | 80-64 | |
| » Starters: Camilo Pascual vs Joe Horlen | Second | 14½ out |
| » Defeated Twins (80-64), 5-4 | Comiskey Park I (41-31) | 81-64 | Won 2 |
| » Starters: Dick Stigman vs Ray Herbert | Second | 14½ out |
| Former White Sox Bill Knickerbocker dies in Sebastopol, CA at the age of 52. |
| Monday, September 9 |
| » Defeated Orioles (77-69), 9-4 | Comiskey Park I (42-31) | 82-64 | Won 3 |
| » Starters: Robin Roberts vs Gary Peters | Second | 13½ out |
| Tuesday, September 10 |
| » Lost to Orioles (78-69), 2-1 | Comiskey Park I (42-32) | 82-65 | |
| » Starters: Milt Pappas vs Frank Baumann | Third | 13½ out |
| Wednesday, September 11 |
| » Defeated Orioles (78-70), 3-2 | Comiskey Park I (43-32) | 83-65 | |
| » Starters: Mike McCormick vs Eddie Fisher | Third | 13½ out |
| Friday, September 13 |
| » Defeated Senators (53-96), 5-2 | Robert F. Kennedy Stadium (6-1) | 84-65 | Won 2 |
| » Starters: Ray Herbert vs Claude Osteen | Second | 14 out |
| Future White Sox Rodney McCray is born in Detroit, MI. |
| Saturday, September 14 |
| » Defeated Senators (53-97), 7-5 | Robert F. Kennedy Stadium (7-1) | 85-65 | Won 3 |
| » Starters: Gary Peters vs Bob Baird | Second | 13½ out |
| » Major-league debuts: Don Buford (White Sox) |
| Tuesday, September 17 |
| » Defeated Red Sox (73-80), 2-1 | Comiskey Park I (44-32) | 86-65 | Won 4 |
| » Starters: Bob Heffner vs Joe Horlen | Second | 13 out |
| Wednesday, September 18 |
| » Defeated Red Sox (73-81), 8-3 | Comiskey Park I (45-32) | 87-65 | Won 5 |
| » Starters: Dave Morehead vs Ray Herbert | Second | 12 out |
| » Defeated Red Sox (73-82), 4-3 | Comiskey Park I (46-32) | 88-65 | Won 6 |
| » Starters: Earl Wilson vs Gary Peters | Second | 12 out |
| Friday, September 20 |
| » Defeated Tigers (75-79), 2-0 | Tiger Stadium (4-3) | 89-65 | Won 7 |
| » |
