| Thursday, January 31 |
| Future Twin Francisco Oliveras is born in Santurce, P.R. |
| Monday, April 8 |
| » Major-league debuts: Tom Brown (Senators) |
| Tuesday, April 9 |
| » Lost to Indians (1-0), 5-4 | Metropolitan Stadium (0-1) | 0-1 | |
| » Starters: Mudcat Grant vs Camilo Pascual | Second | 1 out |
| » Major-league debuts: Jimmie Hall (Twins) Vic Davalillo (Indians) |
| Wednesday, April 10 |
| » Defeated Indians (1-1), 5-3 | Metropolitan Stadium (1-1) | 1-1 | |
| » Starters: Sam McDowell vs Jim Kaat | Second | 1 out |
| Friday, April 12 |
| » Lost to Athletics (1-2), 6-0 | Municipal Stadium (0-1) | 1-2 | |
| » Starters: Jack Kralick vs Ed Rakow | Third | 2 out |
| » Major-league debuts: Fred Lasher (Twins) |
| Saturday, April 13 |
| » Lost to Athletics (2-2), 3-2 | Municipal Stadium (0-2) | 1-3 | Lost 2 |
| » Starters: Dick Stigman vs Dave Wickersham | Third | 2 out |
| Sunday, April 14 |
| » Lost to Athletics (3-2), 5-4 | Municipal Stadium (0-3) | 1-4 | Lost 3 |
| » Starters: Camilo Pascual vs Diego Segui | Fifth | 3 out |
| » Major-league debuts: Paul Ratliff (Twins) |
| Tuesday, April 16 |
| » Defeated Angels (2-3), 11-10 | Metropolitan Stadium (2-1) | 2-4 | |
| » Starters: Dean Chance vs Jim Kaat | Fourth | 2 out |
| Wednesday, April 17 |
| » Lost to Angels (3-3), 4-0 | Metropolitan Stadium (2-2) | 2-5 | |
| » Starters: Don Lee vs Jack Kralick | Eighth | 3 out |
| Thursday, April 18 |
| » Defeated Angels (3-4), 3-0 | Metropolitan Stadium (3-2) | 3-5 | |
| » Starters: Ken McBride vs Dick Stigman | Fifth | 2½ out |
| Friday, April 19 |
| » Lost to White Sox (4-3), 3-1 | Comiskey Park I (0-1) | 3-6 | |
| » Starters: Camilo Pascual vs Juan Pizarro | Sixth | 3 out |
| Saturday, April 20 |
| » Lost to White Sox (5-3), 10-7 | Comiskey Park I (0-2) | 3-7 | Lost 2 |
| » Starters: Jim Kaat vs Joe Horlen | Eighth | 3½ out |
| » Major-league debuts: Garry Roggenburk (Twins) |
| Sunday, April 21 |
| » Defeated White Sox (5-4), 7-0 | Comiskey Park I (1-2) | 4-7 | |
| » Starters: Jim Roland vs Eddie Fisher | Seventh | 3½ out |
| » Lost to White Sox (6-4), 8-0 | Comiskey Park I (1-3) | 4-8 | |
| » Starters: Jack Kralick vs John Buzhardt | Seventh | 3½ out |
| Tuesday, April 23 |
| » Lost to Orioles (8-4), 1-0 | Memorial Stadium (0-1) | 4-9 | Lost 2 |
| » Starters: Dick Stigman vs Milt Pappas | Eighth | 4½ out |
| Wednesday, April 24 |
| » Defeated Senators (4-8), 6-4 | Robert F. Kennedy Stadium (1-0) | 5-9 | |
| » Starters: Camilo Pascual vs Carl Bouldin | Ninth | 4 out |
| Thursday, April 25 |
| » Defeated Senators (4-9), 3-0 | Robert F. Kennedy Stadium (2-0) | 6-9 | Won 2 |
| » Starters: Jack Kralick vs Dave Stenhouse | Eighth | 3½ out |
| Friday, April 26 |
| » Defeated Tigers (7-9), 7-5 | Tiger Stadium (1-0) | 7-9 | Won 3 |
| » Starters: Jim Roland vs Don Mossi | Eighth | 2½ out |
| Saturday, April 27 |
| » Defeated Tigers (7-10), 9-3 | Tiger Stadium (2-0) | 8-9 | Won 4 |
| » Starters: Dick Stigman vs Phil Regan | Fifth | 2½ out |
| Sunday, April 28 |
| » Lost to Tigers (8-10), 4-0 | Tiger Stadium (2-1) | 8-10 | |
| » Starters: Jim Kaat vs Jim Bunning | Seventh | 3½ out |
| Tuesday, April 30 |
| » Defeated Orioles (10-8), 8-1 | Metropolitan Stadium (4-2) | 9-10 | |
| » Starters: Steve Barber vs Camilo Pascual | Seventh | 3 out |
| Wednesday, May 1 |
| » Lost to Red Sox (10-6), 14-5 | Metropolitan Stadium (4-3) | 9-11 | |
| » Starters: Earl Wilson vs Jack Kralick | Seventh | 4 out |
| Friday, May 3 |
| » Lost to Yankees (10-7), 4-3 | Metropolitan Stadium (4-4) | 9-12 | Lost 2 |
| » Starters: Bill Stafford vs Dick Stigman | Seventh | 4½ out |
| Saturday, May 4 |
| » Lost to Yankees (11-7), 3-2 | Metropolitan Stadium (4-5) | 9-13 | Lost 3 |
| » Starters: Stan Williams vs Jim Kaat | Eighth | 5½ out |
| Sunday, May 5 |
| » Defeated Yankees (11-8), 4-1 | Metropolitan Stadium (5-5) | 10-13 | |
| » Starters: Ralph Terry vs Camilo Pascual | Seventh | 4½ out |
| Monday, May 6 |
| » Lost to Angels (13-14), 5-4 | Dodger Stadium (0-1) | 10-14 | |
| » Starters: Jim Roland vs Dean Chance | Eighth | 4½ out |
| Tuesday, May 7 |
| » Lost to Angels (14-14), 2-0 | Dodger Stadium (0-2) | 10-15 | Lost 2 |
| » Starters: Jim Perry vs Bob Turley | Eighth | 4½ out |
| Wednesday, May 8 |
| » Lost to Angels (15-14), 4-3 | Dodger Stadium (0-3) | 10-16 | Lost 3 |
| » Starters: Jim Kaat vs Don Lee | Tenth | 5 out |
| Friday, May 10 |
| » Defeated Athletics (15-13), 2-0 | Metropolitan Stadium (6-5) | 11-16 | |
| » Starters: Orlando Pena vs Camilo Pascual | Tenth | 5½ out |
| » Major-league debuts: Tony LaRussa (Athletics) |
| Saturday, May 11 |
| » Lost to Athletics (16-13), 5-1 | Metropolitan Stadium (6-6) | 11-17 | |
| » Starters: Ted Bowsfield vs Jim Roland | Ninth | 6½ out |
| Sunday, May 12 |
| » Lost to Athletics (17-13), 2-1 | Metropolitan Stadium (6-7) | 11-18 | Lost 2 |
| » Starters: Dave Wickersham vs Jim Perry | Tenth | 7 out |
| Tuesday, May 14 |
| » Lost to Yankees (15-12), 2-1 | Yankee Stadium (0-1) | 11-19 | Lost 3 |
| » Starters: Dick Stigman vs Whitey Ford | Tenth | 7½ out |
| Wednesday, May 15 |
| » Lost to Yankees (16-12), 4-3 | Yankee Stadium (0-2) | 11-20 | Lost 4 |
| » Starters: Camilo Pascual vs Ralph Terry | Ninth | 8½ out |
| Friday, May 17 |
| » Defeated Indians (14-14), 11-4 | Cleveland Stadium (1-0) | 12-20 | |
| » Starters: Jim Perry vs Gary Bell | Eighth | 7½ out |
| Saturday, May 18 |
| » Defeated Indians (14-15), 8-1 | Cleveland Stadium (2-0) | 13-20 | Won 2 |
| » Starters: Jim Kaat vs Sam McDowell | Seventh | 6½ out |
| Sunday, May 19 |
| » Lost to Indians (15-15), 6-4 | Cleveland Stadium (2-1) | 13-21 | |
| » Starters: Dick Stigman vs Pedro Ramos | Eighth | 6½ out |
| » Defeated Indians (15-16), 7-6 | Cleveland Stadium (3-1) | 14-21 | |
| » Starters: Jim Roland vs Mudcat Grant | Eighth | 6½ out |
| Monday, May 20 |
| » Defeated Red Sox (19-14), 6-5 | Fenway Park (1-0) | 15-21 | Won 2 |
| » Starters: Camilo Pascual vs Earl Wilson | Seventh | 6½ out |
| Tuesday, May 21 |
| » Defeated Red Sox (19-15), 8-2 | Fenway Park (2-0) | 16-21 | Won 3 |
| » Starters: Jim Perry vs Dave Morehead | Seventh | 6½ out |
| Wednesday, May 22 |
| » Defeated Red Sox (19-16), 3-1 | Fenway Park (3-0) | 17-21 | Won 4 |
| » Starters: Jim Kaat vs Arnold Earley | Seventh | 6½ out |
| Friday, May 24 |
| » Defeated White Sox (24-16), 8-6 | Metropolitan Stadium (7-7) | 18-21 | Won 5 |
| » Starters: Ray Herbert vs Dick Stigman | Seventh | 7 out |
| Saturday, May 25 |
| » Defeated White Sox (24-17), 6-0 | Metropolitan Stadium (8-7) | 19-21 | Won 6 |
| » Starters: Juan Pizarro vs Camilo Pascual | Sixth | 7 out |
| Sunday, May 26 |
| » Defeated White Sox (24-18), 5-2 | Metropolitan Stadium (9-7) | 20-21 | Won 7 |
| » Starters: John Buzhardt vs Jim Perry | Sixth | 7½ out |
| Tuesday, May 28 |
| » Defeated Senators (15-32), 6-3 | Metropolitan Stadium (10-7) | 21-21 | Won 8 |
| » Starters: Bennie Daniels vs Jim Kaat | Sixth | 7½ out |
| Wednesday, May 29 |
| » Defeated Senators (15-33), 10-1 | Metropolitan Stadium (11-7) | 22-21 | Won 9 |
| » Starters: Dave Stenhouse vs Dick Stigman | Sixth | 6½ out |
| Thursday, May 30 |
| » Defeated Senators (15-34), 3-2 | Metropolitan Stadium (12-7) | 23-21 | Won 10 |
| » Starters: Tom Cheney vs Camilo Pascual | Sixth | 5½ out |
| Friday, May 31 |
| » Lost to Tigers (19-26), 3-1 | Metropolitan Stadium (12-8) | 23-22 | |
| » Starters: Jim Bunning vs Jim Perry | Sixth | 5½ out |
| Saturday, June 1 |
| » Defeated Tigers (19-27), 7-1 | Metropolitan Stadium (13-8) | 24-22 | |
| » Starters: Bob Anderson vs Jim Roland | Fifth | 4½ out |
| Sunday, June 2 |
| » Lost to Tigers (20-27), 7-6 | Metropolitan Stadium (13-9) | 24-23 | |
| » Starters: Bill Faul vs Jim Kaat | Fifth | 4 out |
| Monday, June 3 |
| » Lost to Athletics (26-21), 4-1 | Municipal Stadium (0-4) | 24-24 | Lost 2 |
| » Starters: Camilo Pascual vs Dave Wickersham | Fifth | 4½ out |
| Tuesday, June 4 |
| » Defeated Athletics (26-22), 5-0 | Municipal Stadium (1-4) | 25-24 | |
| » Starters: Jim Perry vs Ed Rakow | Fifth | 5 out |
| Wednesday, June 5 |
| » Defeated Athletics (26-23), 4-0 | Municipal Stadium (2-4) | 26-24 | Won 2 |
| » Starters: Jim Roland vs Orlando Pena | Fifth | 3½ out |
| Friday, June 7 |
| » Defeated Angels (26-30), 6-1 | Dodger Stadium (1-3) | 27-24 | Won 3 |
| » Starters: Jim Kaat vs Dean Chance | Fourth | 4 out |
| Saturday, June 8 |
| » Defeated Angels (26-31), 9-3 | Dodger Stadium (2-3) | 28-24 | Won 4 |
| » Starters: Camilo Pascual vs Dan Osinski | Fourth | 3 out |
| Sunday, June 9 |
| » Lost to Angels (27-31), 4-2 | Dodger Stadium (2-4) | 28-25 | |
| » Starters: Jim Perry vs Ken McBride | Fourth | 3½ out |
| Tuesday, June 11 |
| » Defeated White Sox (33-24), 8-6 | Comiskey Park I (2-3) | 29-25 | |
| » Starters: Dick Stigman vs Ray Herbert | Fourth | 2½ out |
| Wednesday, June 12 |
| » Lost to Athletics (29-26), 12-4 | Metropolitan Stadium (13-10) | 29-26 | |
| » Starters: Dave Wickersham vs Jim Kaat | Fourth | 2 out |
| » Defeated Athletics (29-27), 8-1 | Metropolitan Stadium (14-10) | 30-26 | |
| » Starters: Orlando Pena vs Camilo Pascual | Fourth | 2 out |
| Thursday, June 13 |
| » Defeated Athletics (29-28), 6-3 | Metropolitan Stadium (15-10) | 31-26 | Won 2 |
| » Starters: Moe Drabowsky vs Jim Perry | Fourth | 2 out |
| Friday, June 14 |
| » Defeated Angels (29-34), 3-2 | Metropolitan Stadium (16-10) | 32-26 | Won 3 |
| » Starters: Dan Osinski vs Dick Stigman | Third | 2 out |
| Saturday, June 15 |
| » Lost to Angels (30-34), 9-6 | Metropolitan Stadium (16-11) | 32-27 | |
| » Starters: Ken McBride vs Garry Roggenburk | Fourth | 2 out |
| Sunday, June 16 |
| » Lost to Angels (31-34), 5-3 | Metropolitan Stadium (16-12) | 32-28 | Lost 2 |
| » Starters: Dean Chance vs Jim Kaat | Sixth | 4 out |
| » Lost to Angels (32-34), 5-4 | Metropolitan Stadium (16-13) | 32-29 | Lost 3 |
| » Starters: Bob Turley vs Lee Stange | Sixth | 4 out |
| Tuesday, June 18 |
| » Defeated White Sox (37-27), 5-3 | Metropolitan Stadium (17-13) | 33-29 | |
| » Starters: Joe Horlen vs Jim Perry | Fifth | 4 out |
| Wednesday, June 19 |
| » Lost to White Sox (38-27), 12-4 | Metropolitan Stadium (17-14) | 33-30 | |
| » Starters: Ray Herbert vs Dick Stigman | Sixth | 5 out |
| Thursday, June 20 |
| » Defeated White Sox (38-28), 9-4 | Metropolitan Stadium (18-14) | 34-30 | |
| » Starters: John Buzhardt vs Jim Kaat | Fifth | 5 out |
| Friday, June 21 |
| » Defeated Orioles (35-33), 5-2 | Metropolitan Stadium (19-14) | 35-30 | Won 2 |
| » Starters: Ike Delock vs Lee Stange | Fifth | 4½ out |
| » Lost to Orioles (36-33), 10-2 | Metropolitan Stadium (19-15) | 35-31 | |
| » Starters: Robin Roberts vs Garry Roggenburk | Fifth | 4½ out |
| Saturday, June 22 |
| » Defeated Orioles (36-34), 3-1 | Metropolitan Stadium (20-15) | 36-31 | |
| » Starters: Mike McCormick vs Jim Perry | Fifth | 5 out |
| Sunday, June 23 |
| » Lost to Orioles (37-34), 4-1 | Metropolitan Stadium (20-16) | 36-32 | |
| » Starters: Steve Barber vs Dick Stigman | Fifth | 6 out |
| Monday, June 24 |
| » Defeated Orioles (37-35), 6-4 | Metropolitan Stadium (21-16) | 37-32 | |
| » Starters: Milt Pappas vs Jim Kaat | Fourth | 5 out |
| Tuesday, June 25 |
| » Defeated Tigers (27-41), 1-0 | Metropolitan Stadium (22-16) | 38-32 | Won 2 |
| » Starters: Jim Bunning vs Lee Stange | Fourth | 4 out |
| Wednesday, June 26 |
| » Defeated Tigers (27-42), 6-1 | Metropolitan Stadium (23-16) | 39-32 | Won 3 |
| » Starters: Bill Faul vs Dick Stigman | Fourth | 4 out |
| Thursday, June 27 |
| » Defeated Tigers (27-43), 10-6 | Metropolitan Stadium (24-16) | 40-32 | Won 4 |
| » Starters: Phil Regan vs Jim Perry | Fourth | 3 out |
| Friday, June 28 |
| » Defeated Senators (23-54), 11-4 | Robert F. Kennedy Stadium (3-0) | 41-32 | Won 5 |
| » Starters: Bill Pleis vs Jim Duckworth | Fourth | 2½ out |
| » Defeated Senators (23-55), 10-3 | Robert F. Kennedy Stadium (4-0) | 42-32 | Won 6 |
| » Starters: Jim Kaat vs Tom Cheney | Fourth | 2½ out |
| Sunday, June 30 |
| » Defeated Senators (23-56), 6-2 | Robert F. Kennedy Stadium (5-0) | 43-32 | Won 7 |
| » Starters: Camilo Pascual vs Dave Stenhouse | Third | 2½ out |
| Tuesday, July 2 |
| » Defeated Tigers (29-46), 7-4 | Tiger Stadium (3-1) | 44-32 | Won 8 |
| » Starters: Dick Stigman vs Bill Faul | Second | 3 out |
| Wednesday, July 3 |
| » Lost to Tigers (30-46), 7-5 | Tiger Stadium (3-2) | 44-33 | |
| » Starters: Jim Perry vs Jim Bunning | Second | 4 out |
| Thursday, July 4 |
| » Lost to Tigers (31-46), 5-3 | Tiger Stadium (3-3) | 44-34 | Lost 2 |
| » Starters: Lee Stange vs Phil Regan | Third | 5 out |
| » Lost to Tigers (32-46), 3-1 | Tiger Stadium (3-4) | 44-35 | Lost 3 |
| » Starters: Jim Kaat vs Hank Aguirre | Third | 5 out |
| Friday, July 5 |
| » Lost to Orioles (45-39), 4-3 | Memorial Stadium (0-2) | 44-36 | Lost 4 |
| » Starters: Ray Moore vs Ike Delock | Second | 4½ out |
| » Defeated Orioles (45-40), 7-5 | Memorial Stadium (1-2) | 45-36 | |
| » Starters: Bill Pleis vs Robin Roberts | Second | 4½ out |
| Saturday, July 6 |
| » Lost to Orioles (46-40), 2-1 | Memorial Stadium (1-3) | 45-37 | |
| » Starters: Dick Stigman vs Dave McNally | Third | 5½ out |
| Sunday, July 7 |
| » Lost to Orioles (47-40), 4-3 | Memorial Stadium (1-4) | 45-38 | Lost 2 |
| » Starters: Jim Perry vs Milt Pappas | Fourth | 6 out |
| Wednesday, July 10 |
| » Lost to Red Sox (45-37), 7-4 | Metropolitan Stadium (24-17) | 45-39 | Lost 3 |
| » Starters: Earl Wilson vs Jim Kaat | Fifth | 6½ out |
| Thursday, July 11 |
| » Lost to Red Sox (46-37), 2-0 | Metropolitan Stadium (24-18) | 45-40 | Lost 4 |
| » Starters: Bill Monbouquette vs Dick Stigman | Fifth | 7½ out |
| Friday, July 12 |
| » Lost to Red Sox (47-37), 3-2 | Metropolitan Stadium (24-19) | 45-41 | Lost 5 |
| » Starters: Dave Morehead vs Jim Perry | Sixth | 8½ out |
| Saturday, July 13 |
| » Defeated Red Sox (47-38), 6-4 | Metropolitan Stadium (25-19) | 46-41 | |
| » Starters: Bob Heffner vs Lee Stange | Fifth | 7½ out |
| Sunday, July 14 |
| » Defeated Indians (46-42), 5-3 | Metropolitan Stadium (26-19) | 47-41 | Won 2 |
| » Starters: Pedro Ramos vs Jim Kaat | Fifth | 7½ out |
| » Defeated Indians (46-43), 8-2 | Metropolitan Stadium (27-19) | 48-41 | Won 3 |
| » Starters: Barry Latman vs Bill Pleis | Fifth | 7½ out |
| Monday, July 15 |
| » Defeated Indians (46-44), 13-1 | Metropolitan Stadium (28-19) | 49-41 | Won 4 |
| » Starters: Dick Donovan vs Dick Stigman | Fourth | 6½ out |
| Wednesday, July 17 |
| » Lost to Yankees (55-33), 4-0 | Metropolitan Stadium (28-20) | 49-42 | |
| » Starters: Jim Bouton vs Lee Stange | Fourth | 7½ out |
| Thursday, July 18 |
| » Defeated Yankees (55-34), 9-3 | Metropolitan Stadium (29-20) | 50-42 | |
| » Starters: Ralph Terry vs Camilo Pascual | Fourth | 6½ out |
| Friday, July 19 |
| » Lost to Senators (34-59), 6-5 | Metropolitan Stadium (29-21) | 50-43 | |
| » Starters: Jim Duckworth vs Jim Kaat | Fourth | 7 out |
| Saturday, July 20 |
| » Defeated Senators (34-60), 11-3 | Metropolitan Stadium (30-21) | 51-43 | |
| » Starters: Steve Ridzik vs Dick Stigman | Third | 7 out |
| Sunday, July 21 |
| » Defeated Senators (34-61), 3-2 | Metropolitan Stadium (31-21) | 52-43 | Won 2 |
| » Starters: Don Rudolph vs Jim Perry | Fourth | 7½ out |
| Tuesday, July 23 |
| » Lost to Indians (47-50), 3-2 | Cleveland Stadium (3-2) | 52-44 | |
| » Starters: Camilo Pascual vs Mudcat Grant | Third | 9 out |
| Wednesday, July 24 |
| » Defeated Indians (47-51), 9-0 | Cleveland Stadium (4-2) | 53-44 | |
| » Starters: Dick Stigman vs Pedro Ramos | Second | 8½ out |
| » Defeated Indians (47-52), 5-0 | Cleveland Stadium (5-2) | 54-44 | Won 2 |
| » Starters: Jim Kaat vs Dick Donovan | Second | 8½ out |
| Thursday, July 25 |
| » Lost to Indians (48-52), 3-2 | Cleveland Stadium (5-3) | 54-45 | |
| » Starters: Jim Perry vs Barry Latman | Fourth | 8½ out |
| Friday, July 26 |
| » Lost to Yankees (62-35), 6-5 | Yankee Stadium (0-3) | 54-46 | Lost 2 |
| » Starters: Lee Stange vs Jim Bouton | Fourth | 9½ out |
| Saturday, July 27 |
| » Lost to Yankees (63-35), 5-1 | Yankee Stadium (0-4) | 54-47 | Lost 3 |
| » Starters: Bill Pleis vs Ralph Terry | Fourth | 10½ out |
| Sunday, July 28 |
| » Defeated Yankees (63-36), 5-1 | Yankee Stadium (1-4) | 55-47 | |
| » Starters: Camilo Pascual vs Whitey Ford | Fourth | 10½ out |
| » Lost to Yankees (64-36), 3-2 | Yankee Stadium (1-5) | 55-48 | |
| » Starters: Dick Stigman vs Stan Williams | Fourth | 10½ out |
| Monday, July 29 |
| » Lost to Red Sox (53-49), 7-5 | Fenway Park (3-1) | 55-49 | Lost 2 |
| » Starters: Jim Perry vs Bill Monbouquette | Fourth | 10½ out |
| Tuesday, July 30 |
| » Defeated Red Sox (53-50), 6-3 | Fenway Park (4-1) | 56-49 | |
| » Starters: Jim Kaat vs Bob Turley | Fourth | 10½ out |
| Wednesday, July 31 |
| » Defeated Red Sox (53-51), 9-5 | Fenway Park (5-1) | 57-49 | Won 2 |
| » Starters: Lee Stange vs Bob Heffner | Fourth | 10½ out |
| Friday, August 2 |
| » Defeated Athletics (48-58), 10-3 | Municipal Stadium (3-4) | 58-49 | Won 3 |
| » Starters: Camilo Pascual vs Orlando Pena | Fourth | 9½ out |
| Saturday, August 3 |
| » Defeated Athletics (48-59), 7-2 | Municipal Stadium (4-4) | 59-49 | Won 4 |
| » Starters: Dick Stigman vs Dave Wickersham | Fourth | 9½ out |
| Sunday, August 4 |
| » Lost to Athletics (49-59), 6-2 | Municipal Stadium (4-5) | 59-50 | |
| » Starters: Jim Perry vs Moe Drabowsky | Fourth | 10 out |
| Tuesday, August 6 |
| » Defeated Angels (54-61), 5-1 | Dodger Stadium (3-4) | 60-50 | |
| » Starters: Lee Stange vs Dean Chance | Fourth | 9½ out |
| Wednesday, August 7 |
| » Defeated Angels (54-62), 9-4 | Dodger Stadium (4-4) | 61-50 | Won 2 |
| » Starters: Camilo Pascual vs Ken McBride | Third | 9½ out |
| Thursday, August 8 |
| » Defeated Angels (54-63), 3-0 | Dodger Stadium (5-4) | 62-50 | Won 3 |
| » Starters: Dick Stigman vs Paul Foytack | Third | 9½ out |
| Friday, August 9 |
| » Defeated Red Sox (54-58), 5-3 | Metropolitan Stadium (32-21) | 63-50 | Won 4 |
| » Starters: Dave Morehead vs Jim Perry | Third | 9½ out |
| Saturday, August 10 |
| » Defeated Red Sox (54-59), 5-3 | Metropolitan Stadium (33-21) | 64-50 | Won 5 |
| » Starters: Earl Wilson vs Lee Stange | Third | 9½ out |
| Future Twin Jerald Clark is born in Crockett, TX. |
| Sunday, August 11 |
| » Defeated Red Sox (54-60), 5-2 | Metropolitan Stadium (34-21) | 65-50 | Won 6 |
| » Starters: Bob Turley vs Camilo Pascual | Third | 9½ out |
| Monday, August 12 |
| » Lost to Red Sox (55-60), 5-4 | Metropolitan Stadium (34-22) | 65-51 | |
| » Starters: Bob Heffner vs Jim Kaat | Third | 10 out |
| Tuesday, August 13 |
| » Lost to Orioles (66-54), 6-1 | Metropolitan Stadium (34-23) | 65-52 | Lost 2 |
| » Starters: Steve Barber vs Dick Stigman | Third | 10½ out |
| Wednesday, August 14 |
| » Defeated Orioles (66-55), 2-1 | Metropolitan Stadium (35-23) | 66-52 | |
| » Starters: Robin Roberts vs Jim Perry | Third | 9 out |
| Thursday, August 15 |
| » Defeated Orioles (66-56), 13-3 | Metropolitan Stadium (36-23) | 67-52 | Won 2 |
| » Starters: Milt Pappas vs Lee Stange | Third | 9 out |
| Friday, August 16 |
| » Defeated Senators (43-77), 7-5 | Metropolitan Stadium (37-23) | 68-52 | Won 3 |
| » Starters: Jim Duckworth vs Camilo Pascual | Second | 9 out |
| Saturday, August 17 |
| » Lost to Senators (44-77), 10-0 | Metropolitan Stadium (37-24) | 68-53 | |
| » Starters: Bennie Daniels vs Dick Stigman | Third | 9 out |
| Sunday, August 18 |
| » Lost to Senators (45-77), 7-3 | Metropolitan Stadium (37-25) | 68-54 | Lost 2 |
| » Starters: Steve Ridzik vs Jim Perry | Second | 10½ out |
| Tuesday, August 20 |
| » Lost to Tigers (56-65), 6-0 | Tiger Stadium (3-5) | 68-55 | Lost 3 |
| » Starters: Lee Stange vs Hank Aguirre | Third | 10½ out |
| Wednesday, August 21 |
| » Defeated Tigers (56-66), 12-1 | Tiger Stadium (4-5) | 69-55 | |
| » Starters: Camilo Pascual vs Jim Bunning | Third | 11 out |
| Friday, August 23 |
| » Lost to Orioles (71-58), 14-4 | Memorial Stadium (1-5) | 69-56 | |
| » Starters: Dick Stigman vs Milt Pappas | Fourth | 12 out |
| » Lost to Orioles (72-58), 6-2 | Memorial Stadium (1-6) | 69-57 | Lost 2 |
| » Starters: Jim Perry vs Robin Roberts | Fourth | 12 out |
| Saturday, August 24 |
| » Defeated Orioles (72-59), 1-0 | Memorial Stadium (2-6) | 70-57 | |
| » Starters: Lee Stange vs Dick Hall | Second | 12 out |
| Sunday, August 25 |
| » Defeated Orioles (72-60), 5-3 | Memorial Stadium (3-6) | 71-57 | Won 2 |
| » Starters: Camilo Pascual vs Steve Barber | Second | 11½ out |
| Monday, August 26 |
| » Defeated Senators (47-83), 5-2 | Robert F. Kennedy Stadium (6-0) | 72-57 | Won 3 |
| » Starters: Dick Stigman vs Tom Cheney | Second | 11½ out |
| » Lost to Senators (48-83), 7-3 | Robert F. Kennedy Stadium (6-1) | 72-58 | |
| » Starters: Jim Kaat vs Steve Ridzik | Second | 11½ out |
| » Major-league debuts: Dwight Siebler (Twins) |
| Thursday, August 29 |
| » Defeated Senators (48-84), 14-2 | Robert F. Kennedy Stadium (7-1) | 73-58 | |
| » Starters: Lee Stange vs Don Rudolph | Third | 11½ out |
| » Defeated Senators (48-85), 10-1 | Robert F. Kennedy Stadium (8-1) | 74-58 | Won 2 |
| » Starters: Dwight Siebler vs Jim Duckworth | Third | 11½ out |
| Friday, August 30 |
| » Defeated White Sox (75-59), 5-3 | Metropolitan Stadium (38-25) | 75-58 | Won 3 |
| » Starters: Ray Herbert vs Camilo Pascual | Second | 11½ out |
| Saturday, August 31 |
| » Lost to White Sox (76-59), 2-0 | Metropolitan Stadium (38-26) | 75-59 | |
| » Starters: Joe Horlen vs Dick Stigman | Third | 12½ out |
| Sunday, September 1 |
| » Lost to White Sox (77-59), 8-3 | Metropolitan Stadium (38-27) | 75-60 | Lost 2 |
| » Starters: Eddie Fisher vs Jim Kaat | Third | 13½ out |
| Monday, September 2 |
| » Defeated Athletics (60-75), 6-2 | Metropolitan Stadium (39-27) | 76-60 | |
| » Starters: Dave Wickersham vs Jim Perry | Third | 12½ out |
| » Defeated Athletics (60-76), 3-1 | Metropolitan Stadium (40-27) | 77-60 | Won 2 |
| » Starters: Tom Sturdivant vs Lee Stange | Third | 12½ out |
| Tuesday, September 3 |
| » Lost to Athletics (61-76), 3-2 | Metropolitan Stadium (40-28) | 77-61 | |
| » Starters: Moe Drabowsky vs Camilo Pascual | Third | 12½ out |
| Wednesday, September 4 |
| » Defeated Angels (62-79), 4-2 | Metropolitan Stadium (41-28) | 78-61 | |
| » Starters: Fred Newman vs Dick Stigman | Second | 12½ out |
| Thursday, September 5 |
| » Lost to Angels (63-79), 8-5 | Metropolitan Stadium (41-29) | 78-62 | |
| » Starters: Dean Chance vs Dwight Siebler | Third | 13½ out |
| Friday, September 6 |
| » Defeated White Sox (79-63), 9-8 | Comiskey Park I (3-3) | 79-62 | |
| » Starters: Jim Kaat vs Eddie Fisher | Second | 13½ out |
| Saturday, September 7 |
| » Defeated White Sox (79-64), 4-2 | Comiskey Park I (4-3) | 80-62 | Won 2 |
| » Starters: Lee Stange vs Hoyt Wilhelm | Second | 13½ out |
| Sunday, September 8 |
| » Lost to White Sox (80-64), 5-2 | Comiskey Park I (4-4) | 80-63 | |
| » Starters: Camilo Pascual vs Joe Horlen | Third | 15 out |
| » Lost to White Sox (81-64), 5-4 | Comiskey Park I (4-5) | 80-64 | Lost 2 |
| » Starters: Dick Stigman vs Ray Herbert | Third | 15 out |
| Monday, September 9 |
| » Defeated Indians (70-77), 7-4 | Metropolitan Stadium (42-29) | 81-64 | |
| » Starters: Mudcat Grant vs Jim Perry | Third | 14 out |
| Tuesday, September 10 |
| » Defeated Indians (70-78), 5-4 | Metropolitan Stadium (43-29) | 82-64 | Won 2 |
| » Starters: Barry Latman vs Jim Kaat | Second | 13 out |
| Wednesday, September 11 |
| » Defeated Indians (70-79), 9-3 | Metropolitan Stadium (44-29) | 83-64 | Won 3 |
| » Starters: Dick Donovan vs Lee Stange | Second | 13 out |
| Thursday, September 12 |
| » Defeated Indians (70-80), 3-2 | Metropolitan Stadium (45-29) | 84-64 | Won 4 |
| » Starters: Pedro Ramos vs Dwight Siebler | Second | 13 out |
| Friday, September 13 |
| » Lost to Yankees (98-51), 2-0 | Metropolitan Stadium (45-30) | 84-65 | |
| » Starters: Jim Bouton vs Camilo Pascual | Second | 14 out |
| Saturday, September 14 |
| » Defeated Yankees (98-52), 6-2 | Metropolitan Stadium (46-30) | 85-65 | |
| » Starters: Bill Stafford vs Dick Stigman | Third | 14 out |
| » Lost to Yankees (99-52), 3-1 | Metropolitan Stadium (46-31) | 85-66 | |
| » Starters: Ralph Terry vs Gerry Arrigo | Third | 14 out |
| Sunday, September 15 |
| » Lost to Yankees (100-52), 2-1 | Metropolitan Stadium (46-32) | 85-67 | Lost 2 |
| » Starters: Whitey Ford vs Lee Stange | Third | 15 out |
| Tuesday, September 17 |
| » Defeated Tigers (74-77), 3-1 | Metropolitan Stadium (47-32) | 86-67 | |
| » Starters: Hank Aguirre vs Dwight Siebler | Third | 14 out |
| Wednesday, September 18 |
| » Defeated Tigers (74-78), 10-0 | Metropolitan Stadium (48-32) | 87-67 | Won 2 |
| » Starters: Phil Regan vs Camilo Pascual | Third | 13½ out |
| Thursday, September 19 |
| » Lost to Tigers (75-78), 8-6 | Metropolitan Stadium (48-33) | 87-68 | |
| » Starters: Jim Bunning vs Dick Stigman | Third | 14 out |
| Saturday, September 21 |
| » Defeated Red Sox (73-83), 13-4 | Fenway Park (6-1) | 88-68 | |
| » Starters: Lee Stange vs Bill Monbouquette | Third | 13½ out |
| » Lost to Red Sox (74-83), 11-2 | Fenway Park (6-2) | 88-69 | |
| » Starters: Dwight Siebler vs Gene Conley | Third | 13½ out |
| » Major-league debuts: Rico Petrocelli (Red Sox) |
| Sunday, September 22 |
| » Defeated Red Sox (74-84), 6-1 | Fenway Park (7-2) | 89-69 | |
| » Starters: Camilo Pascual vs Bob Heffner | Third | 13½ out |
| Tuesday, September 24 |
| » Lost to Indians (76-82), 5-1 | Cleveland Stadium (5-4) | 89-70 | |
| » Starters: Dick Stigman vs Mudcat Grant | Third | 14½ out |
| Friday, September 27 |
| » Defeated Yankees (104-56), 4-3 | Yankee Stadium (2-5) | 90-70 | |
| » Starters: Camilo Pascual vs Stan Williams | Third | 14 out |
| Saturday, September 28 |
| » Defeated Yankees (104-57), 6-3 | Yankee Stadium (3-5) | 91-70 | Won 2 |
| » Starters: Lee Stange vs Whitey Ford | Third | 13 out |
| Sunday, December 1 |
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