| Sunday, January 20 |
| Former Tiger Jimmy Wiggs dies in Xenia, OH at the age of 87. |
| Thursday, January 31 |
| Former Tiger Ossie Vitt dies in Oakland, CA at the age of 74. |
| Monday, April 8 |
| » Major-league debuts: Tom Brown (Senators) |
| Tuesday, April 9 |
| » Lost to White Sox (1-0), 7-5 | Tiger Stadium (0-1) | 0-1 | |
| » Starters: Ray Herbert vs Jim Bunning | Second | 1 out |
| » Major-league debuts: Dick Egan (Tigers) |
| Future Tiger Mike Brumley is born in Oklahoma City, OK. |
| Wednesday, April 10 |
| » Defeated White Sox (1-1), 2-1 | Tiger Stadium (1-1) | 1-1 | |
| » Starters: Eddie Fisher vs Hank Aguirre | Second | 1 out |
| Thursday, April 11 |
| » Defeated Indians (1-2), 6-1 | Cleveland Stadium (1-0) | 2-1 | Won 2 |
| » Starters: Don Mossi vs Dick Donovan | Second | 1 out |
| Saturday, April 13 |
| » Defeated Indians (1-3), 4-1 | Cleveland Stadium (2-0) | 3-1 | Won 3 |
| » Starters: Phil Regan vs Pedro Ramos | First | -- |
| Future Tiger Mark Leiter is born in Joliet, IL. |
| Sunday, April 14 |
| » Lost to Indians (2-3), 6-0 | Cleveland Stadium (2-1) | 3-2 | |
| » Starters: Jim Bunning vs Mudcat Grant | Second | 1 out |
| Tuesday, April 16 |
| » Defeated Yankees (4-2), 7-2 | Yankee Stadium (1-0) | 4-2 | |
| » Starters: Hank Aguirre vs Whitey Ford | First | -- |
| Wednesday, April 17 |
| » Defeated Yankees (4-3), 4-2 | Yankee Stadium (2-0) | 5-2 | Won 2 |
| » Starters: Don Mossi vs Ralph Terry | First | -- |
| Friday, April 19 |
| » Lost to Red Sox (4-4), 3-1 | Fenway Park (0-1) | 5-3 | |
| » Starters: Phil Regan vs Gene Conley | Fourth | 1 out |
| » Lost to Red Sox (5-4), 5-1 | Fenway Park (0-2) | 5-4 | Lost 2 |
| » Starters: Frank Lary vs Ike Delock | Fourth | 1 out |
| Saturday, April 20 |
| » Lost to Red Sox (6-4), 4-3 | Fenway Park (0-3) | 5-5 | Lost 3 |
| » Starters: Jim Bunning vs Dave Morehead | Fifth | 1½ out |
| Sunday, April 21 |
| » Defeated Red Sox (6-5), 5-2 | Fenway Park (1-3) | 6-5 | |
| » Starters: Hank Aguirre vs Bill Monbouquette | Third | 1 out |
| Monday, April 22 |
| » Lost to Athletics (7-5), 6-5 | Municipal Stadium (0-1) | 6-6 | |
| » Starters: Don Mossi vs Norm Bass | Fifth | 1½ out |
| Tuesday, April 23 |
| » Lost to Athletics (8-5), 3-1 | Municipal Stadium (0-2) | 6-7 | Lost 2 |
| » Starters: Phil Regan vs Ed Rakow | Fifth | 2½ out |
| Wednesday, April 24 |
| » Defeated Angels (6-8), 4-3 | Tiger Stadium (2-1) | 7-7 | |
| » Starters: Dean Chance vs Jim Bunning | Sixth | 2 out |
| Thursday, April 25 |
| » Lost to Angels (7-8), 7-5 | Tiger Stadium (2-2) | 7-8 | |
| » Starters: Don Lee vs Hank Aguirre | Sixth | 2½ out |
| Friday, April 26 |
| » Lost to Twins (7-9), 7-5 | Tiger Stadium (2-3) | 7-9 | Lost 2 |
| » Starters: Jim Roland vs Don Mossi | Eighth | 2½ out |
| Saturday, April 27 |
| » Lost to Twins (8-9), 9-3 | Tiger Stadium (2-4) | 7-10 | Lost 3 |
| » Starters: Dick Stigman vs Phil Regan | Seventh | 3½ out |
| Sunday, April 28 |
| » Defeated Twins (8-10), 4-0 | Tiger Stadium (3-4) | 8-10 | |
| » Starters: Jim Kaat vs Jim Bunning | Seventh | 3½ out |
| Wednesday, May 1 |
| » Lost to Senators (7-13), 4-1 | Tiger Stadium (3-5) | 8-11 | |
| » Starters: Tom Cheney vs Hank Aguirre | Eighth | 4½ out |
| Thursday, May 2 |
| » Lost to Senators (8-13), 9-4 | Tiger Stadium (3-6) | 8-12 | Lost 2 |
| » Starters: Claude Osteen vs Frank Lary | Ninth | 4 out |
| Friday, May 3 |
| » Lost to Orioles (12-10), 8-5 | Tiger Stadium (3-7) | 8-13 | Lost 3 |
| » Starters: Chuck Estrada vs Don Mossi | Ninth | 5½ out |
| Saturday, May 4 |
| » Lost to Orioles (13-10), 8-4 | Tiger Stadium (3-8) | 8-14 | Lost 4 |
| » Starters: Steve Barber vs Jim Bunning | Tenth | 6½ out |
| Sunday, May 5 |
| » Defeated Orioles (13-11), 12-4 | Tiger Stadium (4-8) | 9-14 | |
| » Starters: Dick Hall vs Phil Regan | Ninth | 5½ out |
| Monday, May 6 |
| » Lost to Yankees (12-8), 10-3 | Tiger Stadium (4-9) | 9-15 | |
| » Starters: Whitey Ford vs Hank Aguirre | Tenth | 5½ out |
| Tuesday, May 7 |
| » Defeated Yankees (12-9), 6-2 | Tiger Stadium (5-9) | 10-15 | |
| » Starters: Bill Stafford vs Don Mossi | Eighth | 4½ out |
| Wednesday, May 8 |
| » Defeated Yankees (12-10), 7-6 | Tiger Stadium (6-9) | 11-15 | Won 2 |
| » Starters: Stan Williams vs Jim Bunning | Eighth | 4 out |
| Friday, May 10 |
| » Defeated Indians (10-12), 14-0 | Tiger Stadium (7-9) | 12-15 | Won 3 |
| » Starters: Gary Bell vs Phil Regan | Eighth | 4½ out |
| Saturday, May 11 |
| » Lost to Indians (11-12), 6-5 | Tiger Stadium (7-10) | 12-16 | |
| » Starters: Dick Donovan vs Hank Aguirre | Seventh | 5½ out |
| » Major-league debuts: Don Wert (Tigers) |
| Sunday, May 12 |
| » Lost to Indians (12-12), 9-3 | Tiger Stadium (7-11) | 12-17 | Lost 2 |
| » Starters: Sam McDowell vs Don Mossi | Ninth | 6 out |
| » Major-league debuts: Mickey Lolich (Tigers) |
| Tuesday, May 14 |
| » Lost to White Sox (19-12), 3-0 | Comiskey Park I (0-1) | 12-18 | Lost 3 |
| » Starters: Jim Bunning vs Ray Herbert | Eighth | 6½ out |
| Wednesday, May 15 |
| » Lost to White Sox (20-12), 7-4 | Comiskey Park I (0-2) | 12-19 | Lost 4 |
| » Starters: Phil Regan vs Juan Pizarro | Seventh | 7½ out |
| Thursday, May 16 |
| Former Tiger Larry Woodall dies in Cambridge, MA at the age of 69. |
| Saturday, May 18 |
| » Defeated Senators (13-23), 6-3 | Robert F. Kennedy Stadium (1-0) | 13-19 | |
| » Starters: Hank Aguirre vs Claude Osteen | Seventh | 6½ out |
| » Lost to Senators (14-23), 7-5 | Robert F. Kennedy Stadium (1-1) | 13-20 | |
| » Starters: Jim Bunning vs Art Quirk | Seventh | 6½ out |
| Sunday, May 19 |
| » Defeated Senators (14-24), 5-1 | Robert F. Kennedy Stadium (2-1) | 14-20 | |
| » Starters: Bill Faul vs Dave Stenhouse | Seventh | 6 out |
| Monday, May 20 |
| » Lost to Orioles (22-15), 6-0 | Memorial Stadium (0-1) | 14-21 | |
| » Starters: Phil Regan vs Milt Pappas | Eighth | 7 out |
| Future Tiger David Wells is born in Torrance, CA. |
| Tuesday, May 21 |
| » Lost to Orioles (23-15), 4-2 | Memorial Stadium (0-2) | 14-22 | Lost 2 |
| » Starters: Mickey Lolich vs Chuck Estrada | Eighth | 8 out |
| Wednesday, May 22 |
| » Lost to Orioles (24-15), 2-1 | Memorial Stadium (0-3) | 14-23 | Lost 3 |
| » Starters: Jim Bunning vs Steve Barber | Eighth | 9 out |
| Friday, May 24 |
| » Lost to Red Sox (20-16), 5-2 | Tiger Stadium (7-12) | 14-24 | Lost 4 |
| » Starters: Bill Monbouquette vs Hank Aguirre | Ninth | 10½ out |
| Saturday, May 25 |
| » Defeated Red Sox (20-17), 5-2 | Tiger Stadium (8-12) | 15-24 | |
| » Starters: Earl Wilson vs Bill Faul | Ninth | 10½ out |
| Sunday, May 26 |
| » Defeated Red Sox (20-18), 12-3 | Tiger Stadium (9-12) | 16-24 | Won 2 |
| » Starters: Dave Morehead vs Jim Bunning | Ninth | 11½ out |
| » Lost to Red Sox (21-18), 6-5 | Tiger Stadium (9-13) | 16-25 | |
| » Starters: Chet Nichols vs Phil Regan | Ninth | 11½ out |
| Monday, May 27 |
| Future Tiger Edwin Nunez is born in Humacao, P.R. |
| Tuesday, May 28 |
| » Defeated Angels (20-26), 3-1 | Dodger Stadium (1-0) | 17-25 | |
| » Starters: Mickey Lolich vs Ken McBride | Ninth | 11½ out |
| Wednesday, May 29 |
| » Lost to Angels (21-26), 4-2 | Dodger Stadium (1-1) | 17-26 | |
| » Starters: Bill Faul vs Dean Chance | Ninth | 11½ out |
| Thursday, May 30 |
| » Defeated Angels (21-27), 3-0 | Dodger Stadium (2-1) | 18-26 | |
| » Starters: Hank Aguirre vs Bob Turley | Ninth | 10½ out |
| Friday, May 31 |
| » Defeated Twins (23-22), 3-1 | Metropolitan Stadium (1-0) | 19-26 | Won 2 |
| » Starters: Jim Bunning vs Jim Perry | Eighth | 9½ out |
| Saturday, June 1 |
| » Lost to Twins (24-22), 7-1 | Metropolitan Stadium (1-1) | 19-27 | |
| » Starters: Bob Anderson vs Jim Roland | Eighth | 9½ out |
| Sunday, June 2 |
| » Defeated Twins (24-23), 7-6 | Metropolitan Stadium (2-1) | 20-27 | |
| » Starters: Bill Faul vs Jim Kaat | Ninth | 8 out |
| Tuesday, June 4 |
| » Lost to Indians (20-25), 6-4 | Cleveland Stadium (2-2) | 20-28 | |
| » Starters: Mickey Lolich vs Barry Latman | Ninth | 9½ out |
| Wednesday, June 5 |
| » Defeated Indians (20-26), 5-4 | Cleveland Stadium (3-2) | 21-28 | |
| » Starters: Jim Bunning vs Mudcat Grant | Ninth | 8 out |
| Friday, June 7 |
| » Defeated Yankees (27-20), 8-4 | Tiger Stadium (10-13) | 22-28 | Won 2 |
| » Starters: Bill Stafford vs Hank Aguirre | Ninth | 8½ out |
| Saturday, June 8 |
| » Defeated Yankees (27-21), 8-4 | Tiger Stadium (11-13) | 23-28 | Won 3 |
| » Starters: Ralph Terry vs Don Mossi | Ninth | 7½ out |
| Sunday, June 9 |
| » Lost to Yankees (28-21), 6-2 | Tiger Stadium (11-14) | 23-29 | |
| » Starters: Whitey Ford vs Mickey Lolich | Ninth | 8 out |
| Monday, June 10 |
| » Defeated Red Sox (25-25), 6-1 | Tiger Stadium (12-14) | 24-29 | |
| » Starters: Dave Morehead vs Bill Faul | Ninth | 7½ out |
| Tuesday, June 11 |
| » Lost to Red Sox (26-25), 7-3 | Tiger Stadium (12-15) | 24-30 | |
| » Starters: Wilbur Wood vs Jim Bunning | Ninth | 7½ out |
| Wednesday, June 12 |
| » Lost to Indians (26-26), 12-6 | Tiger Stadium (12-16) | 24-31 | Lost 2 |
| » Starters: Dick Donovan vs Hank Aguirre | Ninth | 7½ out |
| Thursday, June 13 |
| » Lost to Indians (27-26), 5-3 | Tiger Stadium (12-17) | 24-32 | Lost 3 |
| » Starters: Jack Kralick vs Phil Regan | Ninth | 8½ out |
| Friday, June 14 |
| » Lost to Yankees (31-23), 4-2 | Yankee Stadium (2-1) | 24-33 | Lost 4 |
| » Starters: Don Mossi vs Jim Bouton | Ninth | 9½ out |
| Saturday, June 15 |
| » Lost to Yankees (32-23), 9-2 | Yankee Stadium (2-2) | 24-34 | Lost 5 |
| » Starters: Mickey Lolich vs Al Downing | Ninth | 9½ out |
| Sunday, June 16 |
| » Lost to Yankees (33-23), 4-0 | Yankee Stadium (2-3) | 24-35 | Lost 6 |
| » Starters: Jim Bunning vs Ralph Terry | Ninth | 11½ out |
| » Lost to Yankees (34-23), 6-3 | Yankee Stadium (2-4) | 24-36 | Lost 7 |
| » Starters: Hank Aguirre vs Bill Stafford | Ninth | 11½ out |
| Tuesday, June 18 |
| » Lost to Red Sox (32-26), 9-0 | Fenway Park (1-4) | 24-37 | Lost 8 |
| » Manager: Chuck Dressen |
| » Starters: Bill Faul vs Earl Wilson | Ninth | 12½ out |
| » Major-league debuts: Willie Smith (Tigers) |
| Wednesday, June 19 |
| » Lost to Red Sox (33-26), 9-2 | Fenway Park (1-5) | 24-38 | Lost 9 |
| » Starters: Don Mossi vs Bob Heffner | Ninth | 13½ out |
| » Major-league debuts: Bob Heffner (Red Sox) Gates Brown (Tigers) |
| Thursday, June 20 |
| » Lost to Red Sox (34-26), 8-3 | Fenway Park (1-6) | 24-39 | Lost 10 |
| » Starters: Jim Bunning vs Arnold Earley | Ninth | 14½ out |
| Friday, June 21 |
| » Defeated Athletics (31-34), 6-4 | Municipal Stadium (1-2) | 25-39 | |
| » Starters: Hank Aguirre vs Dave Wickersham | Ninth | 13½ out |
| Saturday, June 22 |
| » Defeated Athletics (31-35), 3-2 | Municipal Stadium (2-2) | 26-39 | Won 2 |
| » Starters: Phil Regan vs Orlando Pena | Ninth | 14 out |
| Sunday, June 23 |
| » Defeated Athletics (31-36), 11-2 | Municipal Stadium (3-2) | 27-39 | Won 3 |
| » Starters: Mickey Lolich vs Moe Drabowsky | Ninth | 14 out |
| Monday, June 24 |
| » Lost to Athletics (32-36), 6-3 | Municipal Stadium (3-3) | 27-40 | |
| » Starters: Don Mossi vs Ed Rakow | Ninth | 14 out |
| Tuesday, June 25 |
| » Lost to Twins (38-32), 1-0 | Metropolitan Stadium (2-2) | 27-41 | Lost 2 |
| » Starters: Jim Bunning vs Lee Stange | Ninth | 14 out |
| Wednesday, June 26 |
| » Lost to Twins (39-32), 6-1 | Metropolitan Stadium (2-3) | 27-42 | Lost 3 |
| » Starters: Bill Faul vs Dick Stigman | Ninth | 15 out |
| Thursday, June 27 |
| » Lost to Twins (40-32), 10-6 | Metropolitan Stadium (2-4) | 27-43 | Lost 4 |
| » Starters: Phil Regan vs Jim Perry | Ninth | 15 out |
| Future Tiger Nelson Simmons is born in Washington, DC. |
| Friday, June 28 |
| » Lost to Angels (40-37), 8-3 | Tiger Stadium (12-18) | 27-44 | Lost 5 |
| » Starters: Dan Osinski vs Hank Aguirre | Ninth | 14½ out |
| » Defeated Angels (40-38), 8-3 | Tiger Stadium (13-18) | 28-44 | |
| » Starters: Bob Turley vs Mickey Lolich | Ninth | 14½ out |
| Saturday, June 29 |
| » Lost to Angels (41-38), 7-4 | Tiger Stadium (13-19) | 28-45 | |
| » Starters: Dean Chance vs Jim Bunning | Ninth | 15½ out |
| Sunday, June 30 |
| » Defeated Angels (41-39), 6-5 | Tiger Stadium (14-19) | 29-45 | |
| » Starters: Ken McBride vs Willie Smith | Ninth | 16 out |
| Tuesday, July 2 |
| » Lost to Twins (44-32), 7-4 | Tiger Stadium (14-20) | 29-46 | |
| » Starters: Dick Stigman vs Bill Faul | Ninth | 17½ out |
| Wednesday, July 3 |
| » Defeated Twins (44-33), 7-5 | Tiger Stadium (15-20) | 30-46 | |
| » Starters: Jim Perry vs Jim Bunning | Ninth | 17½ out |
| Thursday, July 4 |
| » Defeated Twins (44-34), 5-3 | Tiger Stadium (16-20) | 31-46 | Won 2 |
| » Starters: Lee Stange vs Phil Regan | Ninth | 16½ out |
| » Defeated Twins (44-35), 3-1 | Tiger Stadium (17-20) | 32-46 | Won 3 |
| » Starters: Jim Kaat vs Hank Aguirre | Ninth | 16½ out |
| Friday, July 5 |
| » Defeated Athletics (35-44), 4-3 | Tiger Stadium (18-20) | 33-46 | Won 4 |
| » Starters: Dave Wickersham vs Mickey Lolich | Ninth | 15½ out |
| Saturday, July 6 |
| » Defeated Athletics (35-45), 8-4 | Tiger Stadium (19-20) | 34-46 | Won 5 |
| » Starters: Ed Rakow vs Bill Faul | Ninth | 15½ out |
| Sunday, July 7 |
| » Defeated Athletics (35-46), 5-1 | Tiger Stadium (20-20) | 35-46 | Won 6 |
| » Starters: Orlando Pena vs Jim Bunning | Ninth | 15½ out |
| » Lost to Athletics (36-46), 8-7 | Tiger Stadium (20-21) | 35-47 | |
| » Starters: Bill Fischer vs Frank Lary | Ninth | 15½ out |
| Thursday, July 11 |
| » Lost to White Sox (48-38), 6-3 | Comiskey Park I (0-3) | 35-48 | Lost 2 |
| » Starters: Hank Aguirre vs Gary Peters | Eighth | 16½ out |
| Friday, July 12 |
| » Defeated White Sox (48-39), 7-6 | Comiskey Park I (1-3) | 36-48 | |
| » Starters: Don Mossi vs Juan Pizarro | Ninth | 16½ out |
| Monday, July 15 |
| » Lost to Senators (32-58), 11-6 | Robert F. Kennedy Stadium (2-2) | 36-49 | |
| » Starters: Jim Bunning vs Don Rudolph | Ninth | 17 out |
| Tuesday, July 16 |
| » Lost to Orioles (51-43), 5-2 | Tiger Stadium (20-22) | 36-50 | Lost 2 |
| » Starters: Milt Pappas vs Frank Lary | Ninth | 17½ out |
| Wednesday, July 17 |
| » Defeated Orioles (51-44), 9-1 | Tiger Stadium (21-22) | 37-50 | |
| » Starters: Steve Barber vs Hank Aguirre | Ninth | 17½ out |
| Thursday, July 18 |
| » Lost to Orioles (52-44), 8-6 | Tiger Stadium (21-23) | 37-51 | |
| » Starters: Mike McCormick vs Phil Regan | Ninth | 17½ out |
| Friday, July 19 |
| » Defeated Angels (46-51), 10-5 | Dodger Stadium (3-1) | 38-51 | |
| » Starters: Mickey Lolich vs Don Lee | Ninth | 17 out |
| Future Tiger Mark Carreon is born in Chicago, IL. |
| Saturday, July 20 |
| » Lost to Angels (47-51), 11-2 | Dodger Stadium (3-2) | 38-52 | |
| » Starters: Jim Bunning vs Ken McBride | Ninth | 18 out |
| Sunday, July 21 |
| » Defeated Angels (47-52), 8-2 | Dodger Stadium (4-2) | 39-52 | |
| » Starters: Frank Lary vs Dean Chance | Ninth | 18½ out |
| Tuesday, July 23 |
| » Defeated White Sox (52-43), 5-1 | Tiger Stadium (22-23) | 40-52 | Won 2 |
| » Starters: John Buzhardt vs Hank Aguirre | Eighth | 18½ out |
| » Defeated White Sox (52-44), 6-4 | Tiger Stadium (23-23) | 41-52 | Won 3 |
| » Starters: Dave DeBusschere vs Willie Smith | Eighth | 18½ out |
| Wednesday, July 24 |
| » Lost to White Sox (53-44), 3-1 | Tiger Stadium (23-24) | 41-53 | |
| » Starters: Gary Peters vs Don Mossi | Ninth | 19½ out |
| Thursday, July 25 |
| » Lost to White Sox (54-44), 4-3 | Tiger Stadium (23-25) | 41-54 | Lost 2 |
| » Starters: Joe Horlen vs Mickey Lolich | Ninth | 19½ out |
| Friday, July 26 |
| » Lost to Senators (35-64), 3-1 | Tiger Stadium (23-26) | 41-55 | Lost 3 |
| » Starters: Don Rudolph vs Frank Lary | Ninth | 20½ out |
| Saturday, July 27 |
| » Lost to Senators (36-64), 8-4 | Tiger Stadium (23-27) | 41-56 | Lost 4 |
| » Starters: Claude Osteen vs Hank Aguirre | Ninth | 21½ out |
| Former Tiger Hooks Dauss dies in St.Louis, MO at the age of 74. |
| Sunday, July 28 |
| » Defeated Senators (36-65), 3-2 | Tiger Stadium (24-27) | 42-56 | |
| » Starters: Pete Burnside vs Jim Bunning | Ninth | 20½ out |
| » Defeated Senators (36-66), 7-4 | Tiger Stadium (25-27) | 43-56 | Won 2 |
| » Starters: Bennie Daniels vs Phil Regan | Ninth | 20½ out |
| Monday, July 29 |
| » Lost to Orioles (58-49), 2-1 | Memorial Stadium (0-4) | 43-57 | |
| » Starters: Mickey Lolich vs Robin Roberts | Ninth | 20½ out |
| Tuesday, July 30 |
| » Lost to Orioles (59-49), 9-0 | Memorial Stadium (0-5) | 43-58 | Lost 2 |
| » Starters: Hank Aguirre vs Milt Pappas | Ninth | 21½ out |
| Wednesday, July 31 |
| » Lost to Orioles (60-49), 2-1 | Memorial Stadium (0-6) | 43-59 | Lost 3 |
| » Starters: Frank Lary vs Steve Barber | Ninth | 22½ out |
| Friday, August 2 |
| » Defeated Indians (53-56), 10-9 | Tiger Stadium (26-27) | 44-59 | |
| » Starters: Mudcat Grant vs Jim Bunning | Ninth | 21½ out |
| Saturday, August 3 |
| » Defeated Indians (53-57), 7-5 | Tiger Stadium (27-27) | 45-59 | Won 2 |
| » Starters: Dick Donovan vs Phil Regan | Ninth | 21½ out |
| Sunday, August 4 |
| » Defeated Indians (53-58), 2-0 | Tiger Stadium (28-27) | 46-59 | Won 3 |
| » Starters: Jack Kralick vs Hank Aguirre | Ninth | 21½ out |
| » Lost to Indians (54-58), 3-2 | Tiger Stadium (28-28) | 46-60 | |
| » Starters: Pedro Ramos vs Mickey Lolich | Ninth | 21½ out |
| » Major-league debuts: George Smith (Tigers) |
| Tuesday, August 6 |
| » Defeated Red Sox (54-55), 10-1 | Tiger Stadium (29-28) | 47-60 | |
| » Starters: Earl Wilson vs Frank Lary | Ninth | 21 out |
| Wednesday, August 7 |
| » Defeated Red Sox (54-56), 5-4 | Tiger Stadium (30-28) | 48-60 | Won 2 |
| » Starters: Chet Nichols vs Jim Bunning | Ninth | 21 out |
| Thursday, August 8 |
| » Defeated Red Sox (54-57), 6-5 | Tiger Stadium (31-28) | 49-60 | Won 3 |
| » Starters: Bill Monbouquette vs Phil Regan | Eighth | 21 out |
| Friday, August 9 |
| » Lost to White Sox (64-48), 2-1 | Comiskey Park I (1-4) | 49-61 | |
| » Starters: Hank Aguirre vs Joe Horlen | Ninth | 21½ out |
| » Defeated White Sox (64-49), 3-1 | Comiskey Park I (2-4) | 50-61 | |
| » Starters: Mickey Lolich vs Dave DeBusschere | Ninth | 21½ out |
| Saturday, August 10 |
| » Lost to White Sox (65-49), 5-1 | Comiskey Park I (2-5) | 50-62 | |
| » Starters: Bill Faul vs Ray Herbert | Ninth | 22½ out |
| Sunday, August 11 |
| » Defeated White Sox (65-50), 7-2 | Comiskey Park I (3-5) | 51-62 | |
| » Starters: Don Mossi vs Juan Pizarro | Ninth | 23 out |
| » Lost to White Sox (66-50), 3-2 | Comiskey Park I (3-6) | 51-63 | |
| » Starters: Frank Lary vs Gary Peters | Ninth | 23 out |
| Tuesday, August 13 |
| » Lost to Athletics (53-62), 4-2 | Municipal Stadium (3-4) | 51-64 | Lost 2 |
| » Starters: Jim Bunning vs Dave Wickersham | Ninth | 23½ out |
| Wednesday, August 14 |
| » Defeated Athletics (53-63), 5-2 | Municipal Stadium (4-4) | 52-64 | |
| » Starters: Phil Regan vs Moe Drabowsky | Ninth | 22 out |
| Thursday, August 15 |
| » Defeated Athletics (53-64), 11-1 | Municipal Stadium (5-4) | 53-64 | Won 2 |
| » Starters: Hank Aguirre vs Diego Segui | Eighth | 22 out |
| Friday, August 16 |
| » Lost to Angels (57-67), 9-6 | Dodger Stadium (4-3) | 53-65 | |
| » Starters: Mickey Lolich vs Ken McBride | Eighth | 23 out |
| Saturday, August 17 |
| » Defeated Angels (57-68), 6-1 | Dodger Stadium (5-3) | 54-65 | |
| » Starters: Jim Bunning vs Mike Lee | Eighth | 22 out |
| Sunday, August 18 |
| » Defeated Angels (57-69), 3-2 | Dodger Stadium (6-3) | 55-65 | Won 2 |
| » Starters: Alan Koch vs Dean Chance | Sixth | 22½ out |
| Tuesday, August 20 |
| » Defeated Twins (68-55), 6-0 | Tiger Stadium (32-28) | 56-65 | Won 3 |
| » Starters: Lee Stange vs Hank Aguirre | Seventh | 21½ out |
| Wednesday, August 21 |
| » Lost to Twins (69-55), 12-1 | Tiger Stadium (32-29) | 56-66 | |
| » Starters: Camilo Pascual vs Jim Bunning | Seventh | 23 out |
| Friday, August 23 |
| » Defeated Athletics (57-68), 17-2 | Tiger Stadium (33-29) | 57-66 | |
| » Starters: Pete Lovrich vs Frank Lary | Seventh | 22 out |
| » Defeated Athletics (57-69), 6-2 | Tiger Stadium (34-29) | 58-66 | Won 2 |
| » Starters: Dave Wickersham vs Phil Regan | Seventh | 22 out |
| Saturday, August 24 |
| » Defeated Athletics (57-70), 4-3 | Tiger Stadium (35-29) | 59-66 | Won 3 |
| » Starters: Moe Drabowsky vs Mickey Lolich | Sixth | 22 out |
| Sunday, August 25 |
| » Defeated Athletics (57-71), 11-5 | Tiger Stadium (36-29) | 60-66 | Won 4 |
| » Starters: Tom Sturdivant vs Hank Aguirre | Seventh | 21 out |
| » Defeated Athletics (57-72), 4-3 | Tiger Stadium (37-29) | 61-66 | Won 5 |
| » Starters: Orlando Pena vs Jim Bunning | Seventh | 21 out |
| Tuesday, August 27 |
| » Defeated Angels (60-73), 4-1 | Tiger Stadium (38-29) | 62-66 | Won 6 |
| » Starters: Ken McBride vs Phil Regan | Fourth | 21½ out |
| Wednesday, August 28 |
| » Defeated Angels (60-74), 2-1 | Tiger Stadium (39-29) | 63-66 | Won 7 |
| » Starters: Dean Chance vs Frank Lary | Fifth | 21½ out |
| Thursday, August 29 |
| » Defeated Angels (60-75), 6-1 | Tiger Stadium (40-29) | 64-66 | Won 8 |
| » Starters: Fred Newman vs Hank Aguirre | Fifth | 20½ out |
| Friday, August 30 |
| » Lost to Indians (65-72), 5-4 | Cleveland Stadium (3-3) | 64-67 | |
| » Starters: Jim Bunning vs Jack Kralick | Fifth | 21½ out |
| Saturday, August 31 |
| » Defeated Indians (65-73), 9-8 | Cleveland Stadium (4-3) | 65-67 | |
| » Starters: Phil Regan vs Mudcat Grant | Fifth | 21½ out |
| Sunday, September 1 |
| » Lost to Indians (66-73), 6-3 | Cleveland Stadium (4-4) | 65-68 | |
| » Starters: Don Mossi vs Dick Donovan | Fifth | 23 out |
| » Lost to Indians (67-73), 3-1 | Cleveland Stadium (4-5) | 65-69 | Lost 2 |
| » Starters: Mickey Lolich vs Pedro Ramos | Fifth | 23 out |
| Monday, September 2 |
| » Lost to Yankees (90-47), 5-4 | Tiger Stadium (40-30) | 65-70 | Lost 3 |
| » Starters: Whitey Ford vs Frank Lary | Sixth | 23 out |
| » Defeated Yankees (90-48), 2-1 | Tiger Stadium (41-30) | 66-70 | |
| » Starters: Stan Williams vs Hank Aguirre | Sixth | 23 out |
| Tuesday, September 3 |
| » Defeated Yankees (90-49), 3-2 | Tiger Stadium (42-30) | 67-70 | Won 2 |
| » Starters: Al Downing vs Jim Bunning | Fifth | 22 out |
| Wednesday, September 4 |
| » Defeated Red Sox (67-73), 6-1 | Fenway Park (2-6) | 68-70 | Won 3 |
| » Starters: Phil Regan vs Bob Turley | Fifth | 22 out |
| Thursday, September 5 |
| » Defeated Red Sox (67-74), 5-2 | Fenway Park (3-6) | 69-70 | Won 4 |
| » Starters: Bob Anderson vs Earl Wilson | Fifth | 22 out |
| Friday, September 6 |
| » Lost to Yankees (93-49), 2-1 | Yankee Stadium (2-5) | 69-71 | |
| » Starters: Hank Aguirre vs Whitey Ford | Fifth | 23 out |
| Saturday, September 7 |
| » Lost to Yankees (94-49), 11-6 | Yankee Stadium (2-6) | 69-72 | Lost 2 |
| » Starters: Don Mossi vs Stan Williams | Fifth | 24 out |
| Sunday, September 8 |
| » Lost to Yankees (95-49), 5-3 | Yankee Stadium (2-7) | 69-73 | Lost 3 |
| » Starters: Frank Lary vs Al Downing | Fifth | 25 out |
| Monday, September 9 |
| » Defeated Senators (51-93), 1-0 | Robert F. Kennedy Stadium (3-2) | 70-73 | |
| » Starters: Jim Bunning vs Claude Osteen | Fifth | 23½ out |
| » Defeated Senators (51-94), 10-7 | Robert F. Kennedy Stadium (4-2) | 71-73 | Won 2 |
| » Starters: Phil Regan vs Bob Baird | Fifth | 23½ out |
| Tuesday, September 10 |
| » Lost to Senators (52-94), 9-8 | Robert F. Kennedy Stadium (4-3) | 71-74 | |
| » Starters: Hank Aguirre vs Steve Ridzik | Fifth | 23 out |
| » Defeated Senators (52-95), 4-1 | Robert F. Kennedy Stadium (5-3) | 72-74 | |
| » Starters: Mickey Lolich vs Jack Jenkins | Fifth | 23 out |
| » Major-league debuts: Willie Horton (Tigers) |
| Wednesday, September 11 |
| » Lost to Senators (53-95), 6-5 | Robert F. Kennedy Stadium (5-4) | 72-75 | |
| » Starters: Bob Anderson vs Bennie Daniels | Fifth | 24 out |
| Friday, September 13 |
| » Defeated Orioles (78-71), 3-2 | Tiger Stadium (43-30) | 73-75 | |
| » Starters: Steve Barber vs Phil Regan | Fourth | 24½ out |
| Saturday, September 14 |
| » Defeated Orioles (78-72), 3-2 | Tiger Stadium (44-30) | 74-75 | Won 2 |
| » Starters: Robin Roberts vs Jim Bunning | Fifth | 24 out |
| Sunday, September 15 |
| » Lost to Orioles (79-72), 2-1 | Tiger Stadium (44-31) | 74-76 | |
| » Starters: Milt Pappas vs Frank Lary | Fifth | 25 out |
| Tuesday, September 17 |
| » Lost to Twins (86-67), 3-1 | Metropolitan Stadium (2-5) | 74-77 | Lost 2 |
| » Starters: Hank Aguirre vs Dwight Siebler | Fifth | 25 out |
| Wednesday, September 18 |
| » Lost to Twins (87-67), 10-0 | Metropolitan Stadium (2-6) | 74-78 | Lost 3 |
| » Starters: Phil Regan vs Camilo Pascual | Fifth | 25½ out |
| Thursday, September 19 |
| » Defeated Twins (87-68), 8-6 | Metropolitan Stadium (3-6) | 75-78 | |
| » Starters: Jim Bunning vs Dick Stigman | Fifth | 25 out |
| Friday, September 20 |
| » Lost to White Sox (89-65), 2-0 | Tiger Stadium (44-32) | 75-79 | |
| » Starters: Eddie Fisher vs Mickey Lolich | Fifth | 25½ out |
| » Major-league debuts: John Sullivan (Tigers) |
| Saturday, September 21 |
| » Defeated White Sox (89-66), 4-3 | Tiger Stadium (45-32) | 76-79 | |
| » Starters: Fritz Ackley vs Denny McLain | |
