| Wednesday, January 30 |
| Former Senator Win Ballou dies in San Francisco, CA at the age of 66. |
| Friday, February 15 |
| Former Senator Bump Hadley dies in Lynn, MA at the age of 59. |
| Friday, March 1 |
| Former Senator Irish Meusel dies in Long Beach, CA at the age of 70. |
| Monday, March 11 |
| Former Senator Joe Judge dies in Washington, DC at the age of 69. |
| Monday, April 8 |
| » Lost to Orioles (1-0), 3-1 | Robert F. Kennedy Stadium (0-1) | 0-1 | |
| » Starters: Steve Barber vs Don Rudolph | Third | 1 out |
| » Major-league debuts: Tom Brown (Senators) |
| Wednesday, April 10 |
| » Lost to Orioles (2-0), 3-2 | Memorial Stadium (0-1) | 0-2 | Lost 2 |
| » Starters: Claude Osteen vs Robin Roberts | Third | 2 out |
| Thursday, April 11 |
| » Defeated Red Sox (1-2), 8-0 | Robert F. Kennedy Stadium (1-1) | 1-2 | |
| » Starters: Ike Delock vs Tom Cheney | Fourth | 2 out |
| Saturday, April 13 |
| » Lost to Red Sox (2-2), 3-0 | Robert F. Kennedy Stadium (1-2) | 1-3 | |
| » Starters: Dave Morehead vs Don Rudolph | Third | 2 out |
| » Major-league debuts: Jim Duckworth (Senators) Dave Morehead (Red Sox) |
| Sunday, April 14 |
| » Defeated Red Sox (2-3), 7-6 | Robert F. Kennedy Stadium (2-2) | 2-3 | |
| » Starters: Jerry Stephenson vs Bennie Daniels | Fourth | 2 out |
| » Major-league debuts: Jerry Stephenson (Red Sox) |
| Tuesday, April 16 |
| » Lost to Indians (3-3), 3-0 | Cleveland Stadium (0-1) | 2-4 | |
| » Starters: Claude Osteen vs Sam McDowell | Fourth | 2 out |
| Friday, April 19 |
| » Lost to Yankees (5-3), 8-4 | Robert F. Kennedy Stadium (2-3) | 2-5 | Lost 2 |
| » Starters: Stan Williams vs Art Quirk | Seventh | 3 out |
| Saturday, April 20 |
| » Defeated Yankees (5-4), 7-1 | Robert F. Kennedy Stadium (3-3) | 3-5 | |
| » Starters: Bill Stafford vs Dave Stenhouse | Seventh | 2½ out |
| Sunday, April 21 |
| » Lost to Yankees (6-4), 7-6 | Robert F. Kennedy Stadium (3-4) | 3-6 | |
| » Starters: Ralph Terry vs Claude Osteen | Sixth | 3 out |
| Monday, April 22 |
| » Defeated Angels (5-7), 4-1 | Robert F. Kennedy Stadium (4-4) | 4-6 | |
| » Starters: Ken McBride vs Tom Cheney | Seventh | 2½ out |
| Tuesday, April 23 |
| » Lost to Angels (6-7), 5-4 | Robert F. Kennedy Stadium (4-5) | 4-7 | |
| » Starters: Bo Belinsky vs Don Rudolph | Seventh | 3½ out |
| Former Senator Harry Harper dies in New York, NY at the age of 68. |
| Wednesday, April 24 |
| » Lost to Twins (5-9), 6-4 | Robert F. Kennedy Stadium (4-6) | 4-8 | Lost 2 |
| » Starters: Camilo Pascual vs Carl Bouldin | Tenth | 4 out |
| Thursday, April 25 |
| » Lost to Twins (6-9), 3-0 | Robert F. Kennedy Stadium (4-7) | 4-9 | Lost 3 |
| » Starters: Jack Kralick vs Dave Stenhouse | Ninth | 4½ out |
| Friday, April 26 |
| » Lost to Athletics (10-6), 12-10 | Robert F. Kennedy Stadium (4-8) | 4-10 | Lost 4 |
| » Starters: Diego Segui vs Claude Osteen | Ninth | 4 out |
| » Defeated Athletics (10-7), 6-0 | Robert F. Kennedy Stadium (5-8) | 5-10 | |
| » Starters: Ted Bowsfield vs Tom Cheney | Ninth | 4 out |
| Saturday, April 27 |
| » Lost to Athletics (11-7), 7-3 | Robert F. Kennedy Stadium (5-9) | 5-11 | |
| » Starters: Dan Pfister vs Ron Kline | Eighth | 5 out |
| Sunday, April 28 |
| » Lost to Athletics (12-7), 6-5 | Robert F. Kennedy Stadium (5-10) | 5-12 | Lost 2 |
| » Starters: Ed Rakow vs Jim Coates | Ninth | 6 out |
| Monday, April 29 |
| » Defeated Angels (9-10), 9-3 | Dodger Stadium (1-0) | 6-12 | |
| » Starters: Don Rudolph vs Bob Turley | Ninth | 6 out |
| » Lost to Angels (10-10), 13-8 | Dodger Stadium (1-1) | 6-13 | |
| » Starters: Dave Stenhouse vs Don Lee | Ninth | 6 out |
| Wednesday, May 1 |
| » Defeated Tigers (8-11), 4-1 | Tiger Stadium (1-0) | 7-13 | |
| » Starters: Tom Cheney vs Hank Aguirre | Tenth | 6 out |
| Thursday, May 2 |
| » Defeated Tigers (8-12), 9-4 | Tiger Stadium (2-0) | 8-13 | Won 2 |
| » Starters: Claude Osteen vs Frank Lary | Tenth | 4½ out |
| Friday, May 3 |
| » Defeated White Sox (9-9), 5-2 | Comiskey Park I (1-0) | 9-13 | Won 3 |
| » Starters: Don Rudolph vs John Buzhardt | Eighth | 5 out |
| Saturday, May 4 |
| » Lost to White Sox (10-9), 8-1 | Comiskey Park I (1-1) | 9-14 | |
| » Starters: Dave Stenhouse vs Eddie Fisher | Ninth | 6 out |
| Sunday, May 5 |
| » Lost to White Sox (11-9), 8-0 | Comiskey Park I (1-2) | 9-15 | Lost 2 |
| » Starters: Tom Cheney vs Ray Herbert | Eighth | 5½ out |
| » Defeated White Sox (11-10), 8-7 | Comiskey Park I (2-2) | 10-15 | |
| » Starters: Art Quirk vs Joe Horlen | Eighth | 5½ out |
| Tuesday, May 7 |
| » Lost to Indians (10-9), 7-3 | Robert F. Kennedy Stadium (5-11) | 10-16 | |
| » Starters: Sam McDowell vs Claude Osteen | Ninth | 5 out |
| Wednesday, May 8 |
| » Defeated Indians (10-10), 6-3 | Robert F. Kennedy Stadium (6-11) | 11-16 | |
| » Starters: Jack Kralick vs Don Rudolph | Ninth | 4½ out |
| Thursday, May 9 |
| » Defeated Indians (10-11), 6-0 | Robert F. Kennedy Stadium (7-11) | 12-16 | Won 2 |
| » Starters: Mudcat Grant vs Dave Stenhouse | Seventh | 4½ out |
| Friday, May 10 |
| » Lost to Red Sox (13-10), 6-3 | Fenway Park (0-1) | 12-17 | |
| » Starters: Tom Cheney vs Ike Delock | Ninth | 5½ out |
| Sunday, May 12 |
| » Defeated Red Sox (13-11), 3-2 | Fenway Park (1-1) | 13-17 | |
| » Starters: Bennie Daniels vs Earl Wilson | Eighth | 6 out |
| » Lost to Red Sox (14-11), 4-1 | Fenway Park (1-2) | 13-18 | |
| » Starters: Claude Osteen vs Dave Morehead | Eighth | 6 out |
| Monday, May 13 |
| » Lost to Red Sox (15-11), 8-5 | Fenway Park (1-3) | 13-19 | Lost 2 |
| » Starters: Don Rudolph vs Gene Conley | Ninth | 6 out |
| Tuesday, May 14 |
| » Lost to Orioles (17-14), 6-1 | Robert F. Kennedy Stadium (7-12) | 13-20 | Lost 3 |
| » Starters: Robin Roberts vs Dave Stenhouse | Ninth | 7 out |
| Wednesday, May 15 |
| » Lost to Orioles (18-14), 7-1 | Robert F. Kennedy Stadium (7-13) | 13-21 | Lost 4 |
| » Starters: Milt Pappas vs Tom Cheney | Eighth | 8 out |
| Thursday, May 16 |
| » Lost to Orioles (19-14), 9-1 | Memorial Stadium (0-2) | 13-22 | Lost 5 |
| » Starters: Don Rudolph vs Chuck Estrada | Ninth | 8 out |
| Saturday, May 18 |
| » Lost to Tigers (13-19), 6-3 | Robert F. Kennedy Stadium (7-14) | 13-23 | Lost 6 |
| » Starters: Hank Aguirre vs Claude Osteen | Eighth | 7½ out |
| » Defeated Tigers (13-20), 7-5 | Robert F. Kennedy Stadium (8-14) | 14-23 | |
| » Starters: Jim Bunning vs Art Quirk | Eighth | 7½ out |
| Sunday, May 19 |
| » Lost to Tigers (14-20), 5-1 | Robert F. Kennedy Stadium (8-15) | 14-24 | |
| » Starters: Bill Faul vs Dave Stenhouse | Ninth | 8 out |
| Monday, May 20 |
| » Lost to White Sox (22-15), 5-4 | Robert F. Kennedy Stadium (8-16) | 14-25 | Lost 2 |
| » Starters: Eddie Fisher vs Tom Cheney | Ninth | 9 out |
| Tuesday, May 21 |
| » Lost to White Sox (23-15), 4-3 | Robert F. Kennedy Stadium (8-17) | 14-26 | Lost 3 |
| » Starters: John Buzhardt vs Don Rudolph | Ninth | 10 out |
| Wednesday, May 22 |
| » Lost to White Sox (24-15), 9-3 | Robert F. Kennedy Stadium (8-18) | 14-27 | Lost 4 |
| » Manager: Eddie Yost |
| » Starters: Joe Horlen vs Bennie Daniels | Ninth | 11 out |
| Thursday, May 23 |
| » Lost to Orioles (25-15), 6-0 | Memorial Stadium (0-3) | 14-28 | Lost 5 |
| » Manager: Gil Hodges |
| » Starters: Claude Osteen vs Robin Roberts | Tenth | 12 out |
| Former Senator Gavvy Cravath dies in Laguna Beach, CA at the age of 83. |
| Friday, May 24 |
| » Lost to Yankees (21-13), 5-3 | Yankee Stadium (0-1) | 14-29 | Lost 6 |
| » Starters: Dave Stenhouse vs Whitey Ford | Tenth | 13 out |
| Saturday, May 25 |
| » Lost to Yankees (22-13), 5-1 | Yankee Stadium (0-2) | 14-30 | Lost 7 |
| » Starters: Tom Cheney vs Ralph Terry | Tenth | 14 out |
| Sunday, May 26 |
| » Lost to Yankees (23-13), 7-1 | Yankee Stadium (0-3) | 14-31 | Lost 8 |
| » Starters: Don Rudolph vs Jim Bouton | Tenth | 15 out |
| » Defeated Yankees (23-14), 7-6 | Yankee Stadium (1-3) | 15-31 | |
| » Starters: Jim Coates vs Stan Williams | Tenth | 15 out |
| Tuesday, May 28 |
| » Lost to Twins (21-21), 6-3 | Metropolitan Stadium (0-1) | 15-32 | |
| » Starters: Bennie Daniels vs Jim Kaat | Tenth | 16 out |
| Wednesday, May 29 |
| » Lost to Twins (22-21), 10-1 | Metropolitan Stadium (0-2) | 15-33 | Lost 2 |
| » Starters: Dave Stenhouse vs Dick Stigman | Tenth | 16 out |
| Thursday, May 30 |
| » Lost to Twins (23-21), 3-2 | Metropolitan Stadium (0-3) | 15-34 | Lost 3 |
| » Starters: Tom Cheney vs Camilo Pascual | Tenth | 16 out |
| Friday, May 31 |
| » Lost to Athletics (25-19), 9-3 | Municipal Stadium (0-1) | 15-35 | Lost 4 |
| » Starters: Don Rudolph vs Orlando Pena | Tenth | 16 out |
| Saturday, June 1 |
| » Defeated Athletics (25-20), 9-1 | Municipal Stadium (1-1) | 16-35 | |
| » Starters: Jim Duckworth vs Dave Thies | Tenth | 15 out |
| Sunday, June 2 |
| » Defeated Athletics (25-21), 6-4 | Municipal Stadium (2-1) | 17-35 | Won 2 |
| » Starters: Bennie Daniels vs Ted Bowsfield | Tenth | 13½ out |
| Tuesday, June 4 |
| » Defeated Red Sox (23-23), 1-0 | Robert F. Kennedy Stadium (9-18) | 18-35 | Won 3 |
| » Starters: Earl Wilson vs Tom Cheney | Tenth | 14 out |
| Thursday, June 6 |
| » Defeated Red Sox (23-24), 2-1 | Robert F. Kennedy Stadium (10-18) | 19-35 | Won 4 |
| » Starters: Gene Conley vs Dave Stenhouse | Tenth | 13½ out |
| Friday, June 7 |
| » Lost to Indians (21-26), 8-1 | Robert F. Kennedy Stadium (10-19) | 19-36 | |
| » Starters: Dick Donovan vs Jim Duckworth | Tenth | 14 out |
| Saturday, June 8 |
| » Lost to Indians (22-26), 6-1 | Robert F. Kennedy Stadium (10-20) | 19-37 | Lost 2 |
| » Starters: Jack Kralick vs Bennie Daniels | Tenth | 14 out |
| Sunday, June 9 |
| » Lost to Indians (23-26), 7-3 | Robert F. Kennedy Stadium (10-21) | 19-38 | Lost 3 |
| » Starters: Sam McDowell vs Tom Cheney | Tenth | 14½ out |
| Monday, June 10 |
| » Lost to Yankees (29-21), 7-0 | Robert F. Kennedy Stadium (10-22) | 19-39 | Lost 4 |
| » Starters: Al Downing vs Don Rudolph | Tenth | 14½ out |
| » Defeated Yankees (29-22), 1-0 | Robert F. Kennedy Stadium (11-22) | 20-39 | |
| » Starters: Jim Bouton vs Claude Osteen | Tenth | 14½ out |
| Wednesday, June 12 |
| » Lost to Red Sox (27-25), 5-3 | Fenway Park (1-4) | 20-40 | |
| » Starters: Dave Stenhouse vs Bill Monbouquette | Tenth | 14 out |
| Thursday, June 13 |
| » Lost to Red Sox (28-25), 7-5 | Fenway Park (1-5) | 20-41 | Lost 2 |
| » Starters: Jim Duckworth vs Arnold Earley | Tenth | 15 out |
| Friday, June 14 |
| » Defeated Indians (27-27), 5-2 | Cleveland Stadium (1-1) | 21-41 | |
| » Starters: Tom Cheney vs Barry Latman | Tenth | 15½ out |
| » Lost to Indians (28-27), 3-2 | Cleveland Stadium (1-2) | 21-42 | |
| » Starters: Claude Osteen vs Gary Bell | Tenth | 15½ out |
| Saturday, June 15 |
| » Lost to Indians (29-27), 4-0 | Cleveland Stadium (1-3) | 21-43 | Lost 2 |
| » Starters: Bennie Daniels vs Pedro Ramos | Tenth | 15½ out |
| Sunday, June 16 |
| » Lost to Indians (30-27), 4-2 | Cleveland Stadium (1-4) | 21-44 | Lost 3 |
| » Starters: Dave Stenhouse vs Mudcat Grant | Tenth | 17½ out |
| » Lost to Indians (31-27), 6-4 | Cleveland Stadium (1-5) | 21-45 | Lost 4 |
| » Starters: Don Rudolph vs Dick Donovan | Tenth | 17½ out |
| Monday, June 17 |
| » Lost to Indians (32-27), 1-0 | Cleveland Stadium (1-6) | 21-46 | Lost 5 |
| » Starters: Jim Duckworth vs Jack Kralick | Tenth | 18 out |
| Tuesday, June 18 |
| » Lost to Yankees (35-23), 10-5 | Yankee Stadium (1-4) | 21-47 | Lost 6 |
| » Starters: Tom Cheney vs Whitey Ford | Tenth | 19 out |
| Wednesday, June 19 |
| » Lost to Yankees (36-23), 3-2 | Yankee Stadium (1-5) | 21-48 | Lost 7 |
| » Starters: Claude Osteen vs Jim Bouton | Tenth | 20 out |
| Thursday, June 20 |
| » Lost to Yankees (37-23), 5-4 | Yankee Stadium (1-6) | 21-49 | Lost 8 |
| » Starters: Dave Stenhouse vs Al Downing | Tenth | 21 out |
| Friday, June 21 |
| » Lost to Angels (35-35), 1-0 | Dodger Stadium (1-2) | 21-50 | Lost 9 |
| » Starters: Don Rudolph vs Dean Chance | Tenth | 21 out |
| Saturday, June 22 |
| » Lost to Angels (36-35), 9-4 | Dodger Stadium (1-3) | 21-51 | Lost 10 |
| » Starters: Jim Duckworth vs Ken McBride | Tenth | 22½ out |
| Sunday, June 23 |
| » Defeated Angels (36-36), 4-0 | Dodger Stadium (2-3) | 22-51 | |
| » Starters: Tom Cheney vs Dan Osinski | Tenth | 22½ out |
| Monday, June 24 |
| » Lost to Angels (37-36), 3-2 | Dodger Stadium (2-4) | 22-52 | |
| » Starters: Claude Osteen vs Bob Turley | Tenth | 22½ out |
| Tuesday, June 25 |
| » Lost to Athletics (33-36), 8-4 | Municipal Stadium (2-2) | 22-53 | Lost 2 |
| » Starters: Dave Stenhouse vs Diego Segui | Tenth | 22½ out |
| Thursday, June 27 |
| » Defeated Athletics (33-37), 4-2 | Municipal Stadium (3-2) | 23-53 | |
| » Starters: Bennie Daniels vs Dave Wickersham | Tenth | 22 out |
| Friday, June 28 |
| » Lost to Twins (41-32), 11-4 | Robert F. Kennedy Stadium (11-23) | 23-54 | |
| » Starters: Bill Pleis vs Jim Duckworth | Tenth | 22½ out |
| » Lost to Twins (42-32), 10-3 | Robert F. Kennedy Stadium (11-24) | 23-55 | Lost 2 |
| » Starters: Jim Kaat vs Tom Cheney | Tenth | 22½ out |
| Sunday, June 30 |
| » Lost to Twins (43-32), 6-2 | Robert F. Kennedy Stadium (11-25) | 23-56 | Lost 3 |
| » Starters: Camilo Pascual vs Dave Stenhouse | Tenth | 24½ out |
| Tuesday, July 2 |
| » Defeated Athletics (35-41), 7-2 | Robert F. Kennedy Stadium (12-25) | 24-56 | |
| » Starters: Orlando Pena vs Bennie Daniels | Tenth | 25 out |
| Thursday, July 4 |
| » Defeated Athletics (35-42), 2-1 | Robert F. Kennedy Stadium (13-25) | 25-56 | Won 2 |
| » Starters: Moe Drabowsky vs Tom Cheney | Tenth | 24½ out |
| » Defeated Athletics (35-43), 3-2 | Robert F. Kennedy Stadium (14-25) | 26-56 | Won 3 |
| » Starters: Diego Segui vs Claude Osteen | Tenth | 24½ out |
| Friday, July 5 |
| » Defeated Angels (41-43), 5-1 | Robert F. Kennedy Stadium (15-25) | 27-56 | Won 4 |
| » Starters: Dan Osinski vs Don Rudolph | Tenth | 23½ out |
| Saturday, July 6 |
| » Defeated Angels (41-44), 3-2 | Robert F. Kennedy Stadium (16-25) | 28-56 | Won 5 |
| » Starters: Ken McBride vs Dave Stenhouse | Tenth | 23½ out |
| Sunday, July 7 |
| » Defeated Angels (41-45), 7-3 | Robert F. Kennedy Stadium (17-25) | 29-56 | Won 6 |
| » Starters: Dean Chance vs Bennie Daniels | Tenth | 22½ out |
| » Defeated Angels (41-46), 6-4 | Robert F. Kennedy Stadium (18-25) | 30-56 | Won 7 |
| » Starters: Paul Foytack vs Jim Duckworth | Tenth | 22½ out |
| Wednesday, July 10 |
| » Major-league debuts: Jimmy Wynn (Astros) |
| Thursday, July 11 |
| » Lost to Orioles (48-40), 7-4 | Robert F. Kennedy Stadium (18-26) | 30-57 | |
| » Starters: Robin Roberts vs Tom Cheney | Ninth | 23½ out |
| Friday, July 12 |
| » Lost to Orioles (49-40), 4-3 | Robert F. Kennedy Stadium (18-27) | 30-58 | Lost 2 |
| » Starters: Milt Pappas vs Bennie Daniels | Tenth | 24½ out |
| Saturday, July 13 |
| » Defeated Orioles (49-41), 4-3 | Robert F. Kennedy Stadium (19-27) | 31-58 | |
| » Starters: Ike Delock vs Jim Duckworth | Ninth | 23½ out |
| Monday, July 15 |
| » Defeated Tigers (36-49), 11-6 | Robert F. Kennedy Stadium (20-27) | 32-58 | Won 2 |
| » Starters: Jim Bunning vs Don Rudolph | Tenth | 23½ out |
| Tuesday, July 16 |
| » Defeated White Sox (50-41), 3-1 | Comiskey Park I (3-2) | 33-58 | Won 3 |
| » Starters: Claude Osteen vs Juan Pizarro | Tenth | 23 out |
| Wednesday, July 17 |
| » Lost to White Sox (51-41), 8-2 | Comiskey Park I (3-3) | 33-59 | |
| » Starters: Bennie Daniels vs Dave DeBusschere | Tenth | 24 out |
| Friday, July 19 |
| » Defeated Twins (50-43), 6-5 | Metropolitan Stadium (1-3) | 34-59 | |
| » Starters: Jim Duckworth vs Jim Kaat | Tenth | 23 out |
| Saturday, July 20 |
| » Lost to Twins (51-43), 11-3 | Metropolitan Stadium (1-4) | 34-60 | |
| » Starters: Steve Ridzik vs Dick Stigman | Tenth | 24 out |
| Sunday, July 21 |
| » Lost to Twins (52-43), 3-2 | Metropolitan Stadium (1-5) | 34-61 | Lost 2 |
| » Starters: Don Rudolph vs Jim Perry | Tenth | 25½ out |
| Tuesday, July 23 |
| » Lost to Orioles (54-46), 4-0 | Memorial Stadium (0-4) | 34-62 | Lost 3 |
| » Starters: Claude Osteen vs Steve Barber | Ninth | 27 out |
| Wednesday, July 24 |
| » Lost to Orioles (55-46), 8-5 | Memorial Stadium (0-5) | 34-63 | Lost 4 |
| » Starters: Bennie Daniels vs Dave McNally | Tenth | 28 out |
| Thursday, July 25 |
| » Lost to Orioles (56-46), 4-2 | Memorial Stadium (0-6) | 34-64 | Lost 5 |
| » Starters: Tom Cheney vs Robin Roberts | Tenth | 28 out |
| Friday, July 26 |
| » Defeated Tigers (41-55), 3-1 | Tiger Stadium (3-0) | 35-64 | |
| » Starters: Don Rudolph vs Frank Lary | Tenth | 28 out |
| Saturday, July 27 |
| » Defeated Tigers (41-56), 8-4 | Tiger Stadium (4-0) | 36-64 | Won 2 |
| » Starters: Claude Osteen vs Hank Aguirre | Tenth | 28 out |
| Sunday, July 28 |
| » Lost to Tigers (42-56), 3-2 | Tiger Stadium (4-1) | 36-65 | |
| » Starters: Pete Burnside vs Jim Bunning | Tenth | 29 out |
| » Lost to Tigers (43-56), 7-4 | Tiger Stadium (4-2) | 36-66 | Lost 2 |
| » Starters: Bennie Daniels vs Phil Regan | Tenth | 29 out |
| Monday, July 29 |
| » Defeated White Sox (57-46), 2-1 | Robert F. Kennedy Stadium (21-27) | 37-66 | |
| » Starters: Joe Horlen vs Steve Ridzik | Tenth | 28 out |
| Tuesday, July 30 |
| » Lost to White Sox (58-46), 5-1 | Robert F. Kennedy Stadium (21-28) | 37-67 | |
| » Starters: Dave DeBusschere vs Don Rudolph | Tenth | 29 out |
| Wednesday, July 31 |
| » Lost to White Sox (59-46), 5-2 | Robert F. Kennedy Stadium (21-29) | 37-68 | Lost 2 |
| » Starters: Ray Herbert vs Claude Osteen | Tenth | 30 out |
| Friday, August 2 |
| » Lost to Red Sox (54-51), 5-0 | Robert F. Kennedy Stadium (21-30) | 37-69 | Lost 3 |
| » Starters: Earl Wilson vs Bennie Daniels | Tenth | 29½ out |
| » Defeated Red Sox (54-52), 4-3 | Robert F. Kennedy Stadium (22-30) | 38-69 | |
| » Starters: Dave Morehead vs Steve Ridzik | Tenth | 29½ out |
| Saturday, August 3 |
| » Defeated Red Sox (54-53), 5-4 | Robert F. Kennedy Stadium (23-30) | 39-69 | Won 2 |
| » Starters: Bill Monbouquette vs Jim Duckworth | Tenth | 29½ out |
| Sunday, August 4 |
| » Defeated Red Sox (54-54), 7-5 | Robert F. Kennedy Stadium (24-30) | 40-69 | Won 3 |
| » Starters: Bob Turley vs Don Rudolph | Tenth | 29 out |
| Tuesday, August 6 |
| » Defeated Yankees (68-40), 8-5 | Robert F. Kennedy Stadium (25-30) | 41-69 | Won 4 |
| » Starters: Whitey Ford vs Claude Osteen | Tenth | 29 out |
| » Lost to Yankees (69-40), 1-0 | Robert F. Kennedy Stadium (25-31) | 41-70 | |
| » Starters: Stan Williams vs Bennie Daniels | Tenth | 29 out |
| Wednesday, August 7 |
| » Lost to Yankees (70-40), 9-1 | Robert F. Kennedy Stadium (25-32) | 41-71 | Lost 2 |
| » Starters: Al Downing vs Steve Ridzik | Tenth | 30 out |
| Thursday, August 8 |
| » Lost to Yankees (71-40), 3-1 | Robert F. Kennedy Stadium (25-33) | 41-72 | Lost 3 |
| » Starters: Ralph Terry vs Don Rudolph | Tenth | 31 out |
| Friday, August 9 |
| » Lost to Orioles (64-53), 7-1 | Robert F. Kennedy Stadium (25-34) | 41-73 | Lost 4 |
| » Starters: Dave McNally vs Jim Duckworth | Tenth | 32 out |
| Saturday, August 10 |
| » Defeated Orioles (64-54), 6-5 | Robert F. Kennedy Stadium (26-34) | 42-73 | |
| » Starters: Robin Roberts vs Bennie Daniels | Tenth | 32 out |
| Sunday, August 11 |
| » Lost to Orioles (65-54), 6-2 | Robert F. Kennedy Stadium (26-35) | 42-74 | |
| » Starters: Milt Pappas vs Tom Cheney | Tenth | 33 out |
| Tuesday, August 13 |
| » Lost to Angels (55-66), 4-3 | Dodger Stadium (2-5) | 42-75 | Lost 2 |
| » Starters: Don Rudolph vs Don Lee | Tenth | 33½ out |
| Wednesday, August 14 |
| » Lost to Angels (56-66), 2-0 | Dodger Stadium (2-6) | 42-76 | Lost 3 |
| » Starters: Claude Osteen vs Dean Chance | Tenth | 33 out |
| Thursday, August 15 |
| » Defeated Angels (56-67), 5-4 | Dodger Stadium (3-6) | 43-76 | |
| » Starters: Ron Moeller vs Fred Newman | Ninth | 33 out |
| Friday, August 16 |
| » Lost to Twins (68-52), 7-5 | Metropolitan Stadium (1-6) | 43-77 | |
| » Starters: Jim Duckworth vs Camilo Pascual | Ninth | 34 out |
| Saturday, August 17 |
| » Defeated Twins (68-53), 10-0 | Metropolitan Stadium (2-6) | 44-77 | |
| » Starters: Bennie Daniels vs Dick Stigman | Tenth | 33 out |
| Sunday, August 18 |
| » Defeated Twins (68-54), 7-3 | Metropolitan Stadium (3-6) | 45-77 | Won 2 |
| » Starters: Steve Ridzik vs Jim Perry | Ninth | 33½ out |
| Tuesday, August 20 |
| » Lost to Athletics (55-66), 9-0 | Municipal Stadium (3-3) | 45-78 | |
| » Starters: Claude Osteen vs Moe Drabowsky | Tenth | 34 out |
| » Lost to Athletics (56-66), 7-5 | Municipal Stadium (3-4) | 45-79 | Lost 2 |
| » Starters: Jim Duckworth vs Tom Sturdivant | Tenth | 34 out |
| Wednesday, August 21 |
| » Defeated Athletics (56-67), 5-1 | Municipal Stadium (4-4) | 46-79 | |
| » Starters: Ron Moeller vs Orlando Pena | Tenth | 34½ out |
| Thursday, August 22 |
| » Lost to Athletics (57-67), 6-2 | Municipal Stadium (4-5) | 46-80 | |
| » Starters: Bennie Daniels vs Ed Rakow | Tenth | 34½ out |
| Friday, August 23 |
| » Lost to Angels (59-71), 17-0 | Robert F. Kennedy Stadium (26-36) | 46-81 | Lost 2 |
| » Starters: Ken McBride vs Steve Ridzik | Tenth | 35½ out |
| Saturday, August 24 |
| » Lost to Angels (60-71), 10-2 | Robert F. Kennedy Stadium (26-37) | 46-82 | Lost 3 |
| » Starters: Fred Newman vs Don Rudolph | Ninth | 36½ out |
| Sunday, August 25 |
| » Defeated Angels (60-72), 4-1 | Robert F. Kennedy Stadium (27-37) | 47-82 | |
| » Starters: Dan Osinski vs Claude Osteen | Tenth | 36 out |
| Monday, August 26 |
| » Lost to Twins (72-57), 5-2 | Robert F. Kennedy Stadium (27-38) | 47-83 | |
| » Starters: Dick Stigman vs Tom Cheney | Tenth | 36 out |
| » Defeated Twins (72-58), 7-3 | Robert F. Kennedy Stadium (28-38) | 48-83 | |
| » Starters: Jim Kaat vs Steve Ridzik | Tenth | 36 out |
| » Major-league debuts: Dwight Siebler (Twins) |
| Thursday, August 29 |
| » Lost to Twins (73-58), 14-2 | Robert F. Kennedy Stadium (28-39) | 48-84 | |
| » Starters: Lee Stange vs Don Rudolph | Tenth | 38 out |
| » Lost to Twins (74-58), 10-1 | Robert F. Kennedy Stadium (28-40) | 48-85 | Lost 2 |
| » Starters: Dwight Siebler vs Jim Duckworth | Tenth | 38 out |
| Friday, August 30 |
| » Defeated Red Sox (63-71), 7-0 | Fenway Park (2-5) | 49-85 | |
| » Starters: Claude Osteen vs Bob Heffner | Tenth | 38 out |
| Saturday, August 31 |
| » Lost to Red Sox (64-71), 5-4 | Fenway Park (2-6) | 49-86 | |
| » Starters: Steve Ridzik vs Bob Turley | Tenth | 39 out |
| Sunday, September 1 |
| » Lost to Red Sox (65-71), 4-3 | Fenway Park (2-7) | 49-87 | Lost 2 |
| » Starters: Bennie Daniels vs Earl Wilson | Tenth | 40 out |
| Monday, September 2 |
| » Lost to Indians (68-73), 15-3 | Cleveland Stadium (1-7) | 49-88 | Lost 3 |
| » Starters: Don Rudolph vs Jack Kralick | Tenth | 40 out |
| » Defeated Indians (68-74), 8-7 | Cleveland Stadium (2-7) | 50-88 | |
| » Starters: Ed Hobaugh vs Barry Latman | Tenth | 40 out |
| Wednesday, September 4 |
| » Lost to Yankees (91-49), 5-4 | Yankee Stadium (1-7) | 50-89 | |
| » Starters: Claude Osteen vs Jim Bouton | Tenth | 40½ out |
| Thursday, September 5 |
| » Lost to Yankees (92-49), 3-2 | Yankee Stadium (1-8) | 50-90 | Lost 2 |
| » Starters: Steve Ridzik vs Ralph Terry | Tenth | 41½ out |
| Friday, September 6 |
| » Defeated Indians (68-76), 7-2 | Robert F. Kennedy Stadium (29-40) | 51-90 | |
| » Starters: Dick Donovan vs Bennie Daniels | Tenth | 41½ out |
| » Major-league debuts: Tommy John (Indians) |
| Saturday, September 7 |
| » Lost to Indians (69-76), 9-2 | Robert F. Kennedy Stadium (29-41) | 51-91 | |
| » Starters: Pedro Ramos vs Don Rudolph | Tenth | 42½ out |
| Sunday, September 8 |
| » Lost to Indians (70-76), 6-2 | Robert F. Kennedy Stadium (29-42) | 51-92 | Lost 2 |
| » Starters: Jack Kralick vs Jim Duckworth | Tenth | 43½ out |
| Monday, September 9 |
| » Lost to Tigers (70-73), 1-0 | Robert F. Kennedy Stadium (29-43) | 51-93 | Lost 3 |
| » Starters: Jim Bunning vs Claude Osteen | Tenth | 44 out |
| » Lost to Tigers (71-73), 10-7 | Robert F. Kennedy Stadium (29-44) | 51-94 | Lost 4 |
| » Starters: Phil Regan vs Bob Baird | Tenth | 44 out |
| Tuesday, September 10 |
| » Defeated Tigers (71-74), 9-8 | Robert F. Kennedy Stadium (30-44) | 52-94 | |
| » Starters: Hank Aguirre vs Steve Ridzik | Tenth | 43½ out |
| » Lost to Tigers (72-74), 4-1 | Robert F. Kennedy Stadium (30-45) | 52-95 | |
| » Starters: Mickey Lolich vs Jack Jenkins | Tenth | 43½ out |
| » Major-league debuts: Willie Horton (Tigers) |
| Wednesday, September 11 |
| » Defeated Tigers (72-75), 6-5 | Robert F. Kennedy Stadium (31-45) | 53-95 | |
| » Starters: Bob Anderson vs Bennie Daniels | Tenth | 43½ out |
| Friday, September 13 |
| » Lost to White Sox (84-65), 5-2 | Robert F. Kennedy Stadium (31-46) | 53-96 | |
| » Starters: Ray Herbert vs Claude Osteen | Ninth | 45 out |
| Saturday, September 14 |
| » Lost to White Sox (85-65), 7-5 | Robert F. Kennedy Stadium (31-47) | 53-97 | Lost 2 |
| » Starters: Gary Peters vs Bob Baird | Tenth | 45½ out |
| » Major-league debuts: Don Buford (White Sox) |
| Monday, September 16 |
| Former Senator Johnny Niggeling dies in LeMars, IA at the age of 61. |
| Tuesday, September 17 |
| » Lost to Athletics (68-83), 4-3 | Robert F. Kennedy Stadium (31-48) | 53-98 | Lost 3 |
| » Starters: Moe Drabowsky vs Bennie Daniels | Tenth | 46 out |
| Wednesday, September 18 |
| » Lost to Athletics (69-83), 5-4 | Robert F. Kennedy Stadium (31-49) | 53-99 | Lost 4 |
| » Starters: Dave Wickersham vs Claude Osteen | Tenth | 46½ out |
| Friday, September 20 |
| » Lost to Orioles (82-73), 7-6 | Memorial Stadium (0-7) | 53-100 | Lost 5 |
| » Starters: Carl Bouldin vs Milt Pappas | Tenth | 47 out |
| Sunday, September 22 |
| » Lost to Orioles (83-73), 6-3 | Memorial Stadium (0-8) | 53-101 | Lost 6 |
| » Starters: Jack Jenkins vs Robin Roberts | Tenth | 47 out |
| » Defeated Orioles (83-74), 4-2 | Memorial Stadium (1-8) | 54-101 | |
| » Starters: Jim Hannan vs John Miller | Tenth | 47 out |
| Monday, September 23 |
| » Lost to Tigers (77-80), 4-1 | Tiger Stadium (4-3) | 54-102 | |
| » Starters: Bennie Daniels vs Phil Regan | Tenth | 47½ out |
| Tuesday, September 24 |
| » Lost to Tigers (78-80), 1-0 | Tiger Stadium (4-4) | 54-103 | Lost 2 |
| » Starters: Claude Osteen vs Jim Bunning | Tenth | 48½ out |
| Wednesday, September 25 |
| » Defeated Tigers (78-81), 6-2 | Tiger Stadium (5-4) | 55-103 | |
| » Starters: Ron Moeller vs Denny McLain | Tenth | 48½ out |
| Friday, September 27 |
| » Lost to White Sox (92-67), 11-2 | Comiskey Park I (3-4) | 55-104 | |
| » Starters: Bob Baird vs Joe Horlen | Tenth | 49 out |
| » Lost to White Sox (93-67), 7-1 | Comiskey Park I (3-5) | 55-105 | Lost 2 |
| » Starters: Carl Bouldin vs Fritz Ackley | Tenth | 49 out |
| Saturday, September 28 |
| » Lost to White Sox (94-67), 7-2 | Comiskey Park I (3-6) | 55-106 | Lost 3 |
| » Starters: Jim Hannan vs Frank Kreutzer | Ninth | 49 out |
|