| Wednesday, January 2 |
| Future Red Sox David Cone is born in Kansas City, MO. |
| Saturday, January 5 |
| Future Red Sox Jeff Fassero is born in Springfield, IL. |
| Thursday, January 31 |
| Former Red Sox Ossie Vitt dies in Oakland, CA at the age of 74. |
| Monday, February 11 |
| Future Red Sox Todd Benzinger is born in Dayton, KY. |
| Thursday, February 14 |
| Future Red Sox John Marzano is born in Philadelphia, PA. |
| Monday, March 11 |
| Former Red Sox Joe Judge dies in Washington, DC at the age of 69. |
| Thursday, March 14 |
| Future Red Sox Mike Rochford is born in Methuen, MA. |
| Wednesday, March 20 |
| Future Red Sox Dana Williams is born in Weirton, WV. |
| Friday, March 29 |
| Former Red Sox Wilcy Moore dies in Hollis, OK at the age of 66. |
| Monday, April 8 |
| » Major-league debuts: Tom Brown (Senators) |
| Tuesday, April 9 |
| » Lost to Angels (1-0), 4-1 | Dodger Stadium (0-1) | 0-1 | |
| » Starters: Bill Monbouquette vs Ken McBride | Second | 1 out |
| Future Red Sox Mike Brumley is born in Oklahoma City, OK. |
| Wednesday, April 10 |
| » Defeated Angels (1-1), 4-1 | Dodger Stadium (1-1) | 1-1 | |
| » Starters: Earl Wilson vs Dean Chance | Second | 1 out |
| Future Red Sox Jeff Gray is born in Richmond, VA. |
| Thursday, April 11 |
| » Lost to Senators (1-2), 8-0 | Robert F. Kennedy Stadium (0-1) | 1-2 | |
| » Starters: Ike Delock vs Tom Cheney | Fourth | 2 out |
| Friday, April 12 |
| » Major-league debuts: Fred Lasher (Twins) |
| Saturday, April 13 |
| » Defeated Senators (1-3), 3-0 | Robert F. Kennedy Stadium (1-1) | 2-2 | |
| » Starters: Dave Morehead vs Don Rudolph | Second | 1 out |
| » Major-league debuts: Jim Duckworth (Senators) Dave Morehead (Red Sox) |
| Sunday, April 14 |
| » Lost to Senators (2-3), 7-6 | Robert F. Kennedy Stadium (1-2) | 2-3 | |
| » Starters: Jerry Stephenson vs Bennie Daniels | Fourth | 2 out |
| » Major-league debuts: Jerry Stephenson (Red Sox) |
| Tuesday, April 16 |
| » Defeated Orioles (3-3), 6-1 | Fenway Park (1-0) | 3-3 | |
| » Starters: Robin Roberts vs Bill Monbouquette | Second | 1 out |
| Wednesday, April 17 |
| » Lost to Orioles (4-3), 5-4 | Fenway Park (1-1) | 3-4 | |
| » Starters: Steve Barber vs Earl Wilson | Fifth | 2 out |
| Friday, April 19 |
| » Defeated Tigers (5-3), 3-1 | Fenway Park (2-1) | 4-4 | |
| » Starters: Phil Regan vs Gene Conley | Fourth | 1 out |
| » Defeated Tigers (5-4), 5-1 | Fenway Park (3-1) | 5-4 | Won 2 |
| » Starters: Frank Lary vs Ike Delock | Fourth | 1 out |
| Saturday, April 20 |
| » Defeated Tigers (5-5), 4-3 | Fenway Park (4-1) | 6-4 | Won 3 |
| » Starters: Jim Bunning vs Dave Morehead | Third | ½ out |
| Sunday, April 21 |
| » Lost to Tigers (6-5), 5-2 | Fenway Park (4-2) | 6-5 | |
| » Starters: Hank Aguirre vs Bill Monbouquette | Third | 1 out |
| Tuesday, April 23 |
| Former Red Sox Harry Harper dies in New York, NY at the age of 68. |
| Wednesday, April 24 |
| » Lost to Indians (5-6), 2-0 | Cleveland Stadium (0-1) | 6-6 | Lost 2 |
| » Starters: Earl Wilson vs Gary Bell | Fifth | 2 out |
| Saturday, April 27 |
| » Defeated White Sox (7-5), 9-5 | Fenway Park (5-2) | 7-6 | |
| » Starters: Ray Herbert vs Gene Conley | Fourth | 1½ out |
| Sunday, April 28 |
| » Defeated White Sox (7-6), 4-3 | Fenway Park (6-2) | 8-6 | Won 2 |
| » Starters: John Buzhardt vs Ike Delock | Third | 2 out |
| » Defeated White Sox (7-7), 6-2 | Fenway Park (7-2) | 9-6 | Won 3 |
| » Starters: Eddie Fisher vs Bill Monbouquette | Third | 2 out |
| Wednesday, May 1 |
| » Defeated Twins (9-11), 14-5 | Metropolitan Stadium (1-0) | 10-6 | Won 4 |
| » Starters: Earl Wilson vs Jack Kralick | Second | 2 out |
| Friday, May 3 |
| » Lost to Athletics (14-8), 3-1 | Municipal Stadium (0-1) | 10-7 | |
| » Starters: Bill Monbouquette vs Ed Rakow | Second | 2½ out |
| Saturday, May 4 |
| » Lost to Athletics (15-8), 14-3 | Municipal Stadium (0-2) | 10-8 | Lost 2 |
| » Starters: Ike Delock vs Dave Thies | Fourth | 2½ out |
| » Major-league debuts: Jim Gosger (Red Sox) |
| Sunday, May 5 |
| » Defeated Athletics (15-9), 3-2 | Municipal Stadium (1-2) | 11-8 | |
| » Starters: Dave Morehead vs Orlando Pena | Second | 2½ out |
| Tuesday, May 7 |
| » Defeated Orioles (13-12), 5-1 | Memorial Stadium (1-0) | 12-8 | Won 2 |
| » Starters: Earl Wilson vs Robin Roberts | First | -- |
| Wednesday, May 8 |
| » Lost to Orioles (14-12), 10-4 | Memorial Stadium (1-1) | 12-9 | |
| » Starters: Gene Conley vs Steve Barber | Second | 1½ out |
| Thursday, May 9 |
| » Lost to Orioles (15-12), 4-1 | Memorial Stadium (1-2) | 12-10 | Lost 2 |
| » Starters: Bill Monbouquette vs Chuck Estrada | Third | 1½ out |
| Friday, May 10 |
| » Defeated Senators (12-17), 6-3 | Fenway Park (8-2) | 13-10 | |
| » Starters: Tom Cheney vs Ike Delock | Third | 1½ out |
| Sunday, May 12 |
| » Lost to Senators (13-17), 3-2 | Fenway Park (8-3) | 13-11 | |
| » Starters: Bennie Daniels vs Earl Wilson | Third | 2 out |
| » Defeated Senators (13-18), 4-1 | Fenway Park (9-3) | 14-11 | |
| » Starters: Claude Osteen vs Dave Morehead | Third | 2 out |
| Monday, May 13 |
| » Defeated Senators (13-19), 8-5 | Fenway Park (10-3) | 15-11 | Won 2 |
| » Starters: Don Rudolph vs Gene Conley | Second | 2 out |
| Wednesday, May 15 |
| » Defeated Angels (17-18), 9-3 | Fenway Park (11-3) | 16-11 | Won 3 |
| » Starters: Bo Belinsky vs Bill Monbouquette | Second | 2 out |
| » Defeated Angels (17-19), 7-6 | Fenway Park (12-3) | 17-11 | Won 4 |
| » Starters: Ken McBride vs Ike Delock | Second | 2 out |
| Thursday, May 16 |
| » Defeated Angels (17-20), 3-0 | Fenway Park (13-3) | 18-11 | Won 5 |
| » Starters: Dan Osinski vs Earl Wilson | First | -- |
| Friday, May 17 |
| » Lost to Athletics (19-14), 2-0 | Fenway Park (13-4) | 18-12 | |
| » Starters: Ted Bowsfield vs Dave Morehead | Second | 1½ out |
| Sunday, May 19 |
| » Defeated Athletics (19-15), 7-3 | Fenway Park (14-4) | 19-12 | |
| » Starters: Dave Wickersham vs Bill Monbouquette | First | -- |
| » Lost to Athletics (20-15), 9-7 | Fenway Park (14-5) | 19-13 | |
| » Starters: Ed Rakow vs Gene Conley | First | -- |
| Monday, May 20 |
| » Lost to Twins (15-21), 6-5 | Fenway Park (14-6) | 19-14 | Lost 2 |
| » Starters: Camilo Pascual vs Earl Wilson | Third | 2 out |
| Tuesday, May 21 |
| » Lost to Twins (16-21), 8-2 | Fenway Park (14-7) | 19-15 | Lost 3 |
| » Starters: Jim Perry vs Dave Morehead | Third | 2 out |
| Wednesday, May 22 |
| » Lost to Twins (17-21), 3-1 | Fenway Park (14-8) | 19-16 | Lost 4 |
| » Starters: Jim Kaat vs Arnold Earley | Third | 3 out |
| Former Red Sox Dave Shean dies in Boston, MA at the age of 80. |
| Thursday, May 23 |
| Former Red Sox Gavvy Cravath dies in Laguna Beach, CA at the age of 83. |
| Friday, May 24 |
| » Defeated Tigers (14-24), 5-2 | Tiger Stadium (1-0) | 20-16 | |
| » Starters: Bill Monbouquette vs Hank Aguirre | Fourth | 3½ out |
| Saturday, May 25 |
| » Lost to Tigers (15-24), 5-2 | Tiger Stadium (1-1) | 20-17 | |
| » Starters: Earl Wilson vs Bill Faul | Fifth | 4½ out |
| Sunday, May 26 |
| » Lost to Tigers (16-24), 12-3 | Tiger Stadium (1-2) | 20-18 | Lost 2 |
| » Starters: Dave Morehead vs Jim Bunning | Fifth | 5½ out |
| » Defeated Tigers (16-25), 6-5 | Tiger Stadium (2-2) | 21-18 | |
| » Starters: Chet Nichols vs Phil Regan | Fifth | 5½ out |
| Tuesday, May 28 |
| » Defeated Yankees (23-15), 11-6 | Fenway Park (15-8) | 22-18 | Won 2 |
| » Starters: Bill Stafford vs Bill Monbouquette | Fourth | 5½ out |
| Thursday, May 30 |
| » Lost to Yankees (24-15), 6-5 | Fenway Park (15-9) | 22-19 | |
| » Starters: Ralph Terry vs Earl Wilson | Fifth | 5 out |
| Friday, May 31 |
| » Lost to White Sox (27-19), 6-0 | Comiskey Park I (0-1) | 22-20 | Lost 2 |
| » Starters: Gene Conley vs John Buzhardt | Fifth | 5 out |
| Saturday, June 1 |
| » Lost to White Sox (28-19), 3-1 | Comiskey Park I (0-2) | 22-21 | Lost 3 |
| » Starters: Dave Morehead vs Joe Horlen | Sixth | 5 out |
| Sunday, June 2 |
| » Defeated White Sox (28-20), 11-9 | Comiskey Park I (1-2) | 23-21 | |
| » Starters: Bill Monbouquette vs Ray Herbert | Sixth | 4 out |
| » Lost to White Sox (29-20), 10-0 | Comiskey Park I (1-3) | 23-22 | |
| » Starters: Wilbur Wood vs Juan Pizarro | Sixth | 4 out |
| Tuesday, June 4 |
| » Lost to Senators (18-35), 1-0 | Robert F. Kennedy Stadium (1-3) | 23-23 | Lost 2 |
| » Starters: Earl Wilson vs Tom Cheney | Sixth | 5½ out |
| Thursday, June 6 |
| » Lost to Senators (19-35), 2-1 | Robert F. Kennedy Stadium (1-4) | 23-24 | Lost 3 |
| » Starters: Gene Conley vs Dave Stenhouse | Sixth | 6 out |
| Saturday, June 8 |
| » Defeated Orioles (32-22), 7-1 | Memorial Stadium (2-2) | 24-24 | |
| » Starters: Bill Monbouquette vs Steve Barber | Sixth | 5 out |
| Sunday, June 9 |
| » Defeated Orioles (32-23), 3-2 | Memorial Stadium (3-2) | 25-24 | Won 2 |
| » Starters: Earl Wilson vs Milt Pappas | Sixth | 4½ out |
| Monday, June 10 |
| » Lost to Tigers (24-29), 6-1 | Tiger Stadium (2-3) | 25-25 | |
| » Starters: Dave Morehead vs Bill Faul | Sixth | 5 out |
| Tuesday, June 11 |
| » Defeated Tigers (24-30), 7-3 | Tiger Stadium (3-3) | 26-25 | |
| » Starters: Wilbur Wood vs Jim Bunning | Sixth | 4 out |
| Wednesday, June 12 |
| » Defeated Senators (20-40), 5-3 | Fenway Park (16-9) | 27-25 | Won 2 |
| » Starters: Dave Stenhouse vs Bill Monbouquette | Fifth | 3 out |
| Thursday, June 13 |
| » Defeated Senators (20-41), 7-5 | Fenway Park (17-9) | 28-25 | Won 3 |
| » Starters: Jim Duckworth vs Arnold Earley | Fifth | 3 out |
| Friday, June 14 |
| » Defeated Orioles (33-27), 5-1 | Fenway Park (18-9) | 29-25 | Won 4 |
| » Starters: Milt Pappas vs Earl Wilson | Fifth | 3 out |
| Sunday, June 16 |
| » Defeated Orioles (33-28), 8-1 | Fenway Park (19-9) | 30-25 | Won 5 |
| » Starters: Ike Delock vs Bill Monbouquette | Third | 2½ out |
| » Defeated Orioles (33-29), 12-5 | Fenway Park (20-9) | 31-25 | Won 6 |
| » Starters: Robin Roberts vs Dave Morehead | Third | 2½ out |
| Monday, June 17 |
| » Lost to Orioles (34-29), 7-2 | Fenway Park (20-10) | 31-26 | |
| » Starters: Mike McCormick vs Wilbur Wood | Third | 3 out |
| Tuesday, June 18 |
| » Defeated Tigers (24-37), 9-0 | Fenway Park (21-10) | 32-26 | |
| » Starters: Bill Faul vs Earl Wilson | Third | 3 out |
| » Major-league debuts: Willie Smith (Tigers) |
| Wednesday, June 19 |
| » Defeated Tigers (24-38), 9-2 | Fenway Park (22-10) | 33-26 | Won 2 |
| » Starters: Don Mossi vs Bob Heffner | Third | 3 out |
| » Major-league debuts: Bob Heffner (Red Sox) Gates Brown (Tigers) |
| Thursday, June 20 |
| » Defeated Tigers (24-39), 8-3 | Fenway Park (23-10) | 34-26 | Won 3 |
| » Starters: Jim Bunning vs Arnold Earley | Third | 3 out |
| Friday, June 21 |
| » Defeated Yankees (37-24), 7-4 | Fenway Park (24-10) | 35-26 | Won 4 |
| » Starters: Ralph Terry vs Bill Monbouquette | Third | 2 out |
| Saturday, June 22 |
| » Lost to Yankees (38-24), 6-5 | Fenway Park (24-11) | 35-27 | |
| » Starters: Whitey Ford vs Dave Morehead | Third | 4 out |
| » Lost to Yankees (39-24), 3-2 | Fenway Park (24-12) | 35-28 | Lost 2 |
| » Starters: Bill Stafford vs Wilbur Wood | Third | 4 out |
| Sunday, June 23 |
| » Lost to Yankees (40-24), 8-0 | Fenway Park (24-13) | 35-29 | Lost 3 |
| » Starters: Jim Bouton vs Earl Wilson | Third | 5 out |
| Monday, June 24 |
| » Defeated Indians (36-32), 7-5 | Fenway Park (25-13) | 36-29 | |
| » Starters: Gary Bell vs Bob Heffner | Third | 4 out |
| Tuesday, June 25 |
| » Defeated Indians (36-33), 4-1 | Fenway Park (26-13) | 37-29 | Won 2 |
| » Starters: Dick Donovan vs Bill Monbouquette | Third | 2½ out |
| » Defeated Indians (36-34), 3-2 | Fenway Park (27-13) | 38-29 | Won 3 |
| » Starters: Sam McDowell vs Earl Wilson | Third | 2½ out |
| Future Red Sox Mike Stanley is born in Fort Lauderdale, FL. |
| Wednesday, June 26 |
| » Defeated Indians (36-35), 6-5 | Fenway Park (28-13) | 39-29 | Won 4 |
| » Starters: Mudcat Grant vs Dave Morehead | Third | 2½ out |
| Thursday, June 27 |
| » Lost to Indians (37-35), 6-4 | Fenway Park (28-14) | 39-30 | |
| » Starters: Barry Latman vs Wilbur Wood | Third | 2½ out |
| Friday, June 28 |
| » Defeated Yankees (41-28), 4-3 | Yankee Stadium (1-0) | 40-30 | |
| » Starters: Bob Heffner vs Al Downing | Third | 1½ out |
| Saturday, June 29 |
| » Lost to Yankees (42-28), 2-0 | Yankee Stadium (1-1) | 40-31 | |
| » Starters: Chet Nichols vs Ralph Terry | Fourth | 2½ out |
| Sunday, June 30 |
| » Lost to Yankees (43-28), 4-2 | Yankee Stadium (1-2) | 40-32 | Lost 2 |
| » Starters: Bill Monbouquette vs Whitey Ford | Fourth | 4½ out |
| » Lost to Yankees (44-28), 11-4 | Yankee Stadium (1-3) | 40-33 | Lost 3 |
| » Starters: Earl Wilson vs Bill Stafford | Fourth | 4½ out |
| Monday, July 1 |
| » Lost to Yankees (45-28), 7-5 | Yankee Stadium (1-4) | 40-34 | Lost 4 |
| » Starters: Wilbur Wood vs Jim Bouton | Fourth | 5½ out |
| Former Red Sox Earl Moseley dies in Alliance, OH at the age of 79. |
| Tuesday, July 2 |
| » Defeated Indians (40-37), 6-1 | Cleveland Stadium (1-1) | 41-34 | |
| » Starters: Dave Morehead vs Barry Latman | Fourth | 5½ out |
| Wednesday, July 3 |
| » Defeated Indians (40-38), 6-2 | Cleveland Stadium (2-1) | 42-34 | Won 2 |
| » Starters: Bob Heffner vs Pedro Ramos | Fourth | 5½ out |
| Thursday, July 4 |
| » Lost to Indians (41-38), 4-3 | Cleveland Stadium (2-2) | 42-35 | |
| » Starters: Bill Monbouquette vs Early Wynn | Fourth | 6½ out |
| » Lost to Indians (42-38), 7-5 | Cleveland Stadium (2-3) | 42-36 | Lost 2 |
| » Starters: Chet Nichols vs Mudcat Grant | Fourth | 6½ out |
| Friday, July 5 |
| » Defeated White Sox (46-37), 8-3 | Fenway Park (29-14) | 43-36 | |
| » Starters: Dave DeBusschere vs Earl Wilson | Fourth | 5½ out |
| Saturday, July 6 |
| » Defeated White Sox (46-38), 6-2 | Fenway Park (30-14) | 44-36 | Won 2 |
| » Starters: Ray Herbert vs Dave Morehead | Second | 5½ out |
| Sunday, July 7 |
| » Lost to White Sox (47-38), 4-1 | Fenway Park (30-15) | 44-37 | |
| » Starters: Hoyt Wilhelm vs Jack Lamabe | Third | 6 out |
| Wednesday, July 10 |
| » Defeated Twins (45-39), 7-4 | Metropolitan Stadium (2-0) | 45-37 | |
| » Starters: Earl Wilson vs Jim Kaat | Third | 5½ out |
| Thursday, July 11 |
| » Defeated Twins (45-40), 2-0 | Metropolitan Stadium (3-0) | 46-37 | Won 2 |
| » Starters: Bill Monbouquette vs Dick Stigman | Third | 5½ out |
| Friday, July 12 |
| » Defeated Twins (45-41), 3-2 | Metropolitan Stadium (4-0) | 47-37 | Won 3 |
| » Starters: Dave Morehead vs Jim Perry | Second | 5½ out |
| Former Red Sox Jack Cameron dies in Charlotte, NC at the age of 79. |
| Saturday, July 13 |
| » Lost to Twins (46-41), 6-4 | Metropolitan Stadium (4-1) | 47-38 | |
| » Starters: Bob Heffner vs Lee Stange | Second | 5½ out |
| Sunday, July 14 |
| » Lost to Angels (43-48), 10-8 | Dodger Stadium (1-2) | 47-39 | Lost 2 |
| » Starters: Earl Wilson vs Paul Foytack | Second | 6½ out |
| » Defeated Angels (43-49), 5-0 | Dodger Stadium (2-2) | 48-39 | |
| » Starters: Chet Nichols vs Bob Turley | Second | 6½ out |
| Future Red Sox John Dopson is born in Baltimore, MD. |
| Monday, July 15 |
| » Defeated Angels (43-50), 2-1 | Dodger Stadium (3-2) | 49-39 | Won 2 |
| » Starters: Bill Monbouquette vs Don Lee | Second | 5½ out |
| Tuesday, July 16 |
| » Lost to Athletics (39-50), 11-0 | Municipal Stadium (1-3) | 49-40 | |
| » Starters: Dave Morehead vs Moe Drabowsky | Second | 6 out |
| Wednesday, July 17 |
| » Lost to Athletics (40-50), 8-1 | Municipal Stadium (1-4) | 49-41 | Lost 2 |
| » Starters: Bob Heffner vs Diego Segui | Third | 7 out |
| Thursday, July 18 |
| » Defeated Athletics (40-51), 10-6 | Municipal Stadium (2-4) | 50-41 | |
| » Starters: Chet Nichols vs Ed Rakow | Third | 6 out |
| Future Red Sox Mike Greenwell is born in Louisville, KY. |
| Saturday, July 20 |
| » Lost to White Sox (52-41), 3-0 | Comiskey Park I (1-4) | 50-42 | |
| » Starters: Earl Wilson vs Gary Peters | Fourth | 7 out |
| Sunday, July 21 |
| » Defeated White Sox (52-42), 3-2 | Comiskey Park I (2-4) | 51-42 | |
| » Starters: Bill Monbouquette vs Juan Pizarro | Third | 7½ out |
| Tuesday, July 23 |
| » Lost to Athletics (43-52), 1-0 | Fenway Park (30-16) | 51-43 | |
| » Starters: Diego Segui vs Bob Heffner | Second | 9 out |
| Wednesday, July 24 |
| » Lost to Athletics (44-52), 5-2 | Fenway Park (30-17) | 51-44 | Lost 2 |
| » Starters: Orlando Pena vs Earl Wilson | Fifth | 10½ out |
| » Lost to Athletics (45-52), 7-6 | Fenway Park (30-18) | 51-45 | Lost 3 |
| » Starters: Dave Wickersham vs Dave Morehead | Fifth | 10½ out |
| Thursday, July 25 |
| » Lost to Athletics (46-52), 2-0 | Fenway Park (30-19) | 51-46 | Lost 4 |
| » Starters: Ed Rakow vs Bill Monbouquette | Fifth | 10½ out |
| Friday, July 26 |
| » Defeated Angels (48-56), 5-4 | Fenway Park (31-19) | 52-46 | |
| » Starters: Fred Newman vs Bob Turley | Fifth | 10½ out |
| Saturday, July 27 |
| » Lost to Angels (49-56), 5-2 | Fenway Park (31-20) | 52-47 | |
| » Starters: Dan Osinski vs Bob Heffner | Fifth | 11½ out |
| Sunday, July 28 |
| » Lost to Angels (50-56), 5-0 | Fenway Park (31-21) | 52-48 | Lost 2 |
| » Starters: Don Lee vs Earl Wilson | Fifth | 12½ out |
| » Lost to Angels (51-56), 5-4 | Fenway Park (31-22) | 52-49 | Lost 3 |
| » Starters: Paul Foytack vs Dave Morehead | Fifth | 12½ out |
| Monday, July 29 |
| » Defeated Twins (55-49), 7-5 | Fenway Park (32-22) | 53-49 | |
| » Starters: Jim Perry vs Bill Monbouquette | Fifth | 11½ out |
| Tuesday, July 30 |
| » Lost to Twins (56-49), 6-3 | Fenway Park (32-23) | 53-50 | |
| » Starters: Jim Kaat vs Bob Turley | Fifth | 12½ out |
| Wednesday, July 31 |
| » Lost to Twins (57-49), 9-5 | Fenway Park (32-24) | 53-51 | Lost 2 |
| » Starters: Lee Stange vs Bob Heffner | Fifth | 13½ out |
| Future Red Sox Scott Bankhead is born in Raleigh, NC. |
| Friday, August 2 |
| » Defeated Senators (37-69), 5-0 | Robert F. Kennedy Stadium (2-4) | 54-51 | |
| » Starters: Earl Wilson vs Bennie Daniels | Fifth | 13 out |
| » Lost to Senators (38-69), 4-3 | Robert F. Kennedy Stadium (2-5) | 54-52 | |
| » Starters: Dave Morehead vs Steve Ridzik | Fifth | 13 out |
| Saturday, August 3 |
| » Lost to Senators (39-69), 5-4 | Robert F. Kennedy Stadium (2-6) | 54-53 | Lost 2 |
| » Starters: Bill Monbouquette vs Jim Duckworth | Fifth | 14 out |
| Sunday, August 4 |
| » Lost to Senators (40-69), 7-5 | Robert F. Kennedy Stadium (2-7) | 54-54 | Lost 3 |
| » Starters: Bob Turley vs Don Rudolph | Fifth | 14½ out |
| Tuesday, August 6 |
| » Lost to Tigers (47-60), 10-1 | Tiger Stadium (3-4) | 54-55 | Lost 4 |
| » Starters: Earl Wilson vs Frank Lary | Fifth | 15 out |
| Wednesday, August 7 |
| » Lost to Tigers (48-60), 5-4 | Tiger Stadium (3-5) | 54-56 | Lost 5 |
| » Starters: Chet Nichols vs Jim Bunning | Fifth | 16 out |
| Thursday, August 8 |
| » Lost to Tigers (49-60), 6-5 | Tiger Stadium (3-6) | 54-57 | Lost 6 |
| » Starters: Bill Monbouquette vs Phil Regan | Sixth | 17 out |
| Friday, August 9 |
| » Lost to Twins (63-50), 5-3 | Metropolitan Stadium (4-2) | 54-58 | Lost 7 |
| » Starters: Dave Morehead vs Jim Perry | Sixth | 18 out |
| Saturday, August 10 |
| » Lost to Twins (64-50), 5-3 | Metropolitan Stadium (4-3) | 54-59 | Lost 8 |
| » Starters: Earl Wilson vs Lee Stange | Sixth | 19 out |
| Sunday, August 11 |
| » Lost to Twins (65-50), 5-2 | Metropolitan Stadium (4-4) | 54-60 | Lost 9 |
| » Starters: Bob Turley vs Camilo Pascual | Sixth | 20 out |
| Monday, August 12 |
| » Defeated Twins (65-51), 5-4 | Metropolitan Stadium (5-4) | 55-60 | |
| » Starters: Bob Heffner vs Jim Kaat | Sixth | 19½ out |
| Wednesday, August 14 |
| » Defeated Yankees (74-41), 14-7 | Fenway Park (33-24) | 56-60 | Won 2 |
| » Starters: Ralph Terry vs Bill Monbouquette | Fifth | 17½ out |
| » Defeated Yankees (74-42), 5-4 | Fenway Park (34-24) | 57-60 | Won 3 |
| » Starters: Jim Bouton vs Dave Morehead | Fifth | 17½ out |
| Thursday, August 15 |
| » Lost to Yankees (75-42), 10-2 | Fenway Park (34-25) | 57-61 | |
| » Starters: Stan Williams vs Earl Wilson | Fifth | 18½ out |
| Friday, August 16 |
| » Defeated Indians (58-63), 7-4 | Fenway Park (35-25) | 58-61 | |
| » Starters: Jack Kralick vs Bob Heffner | Fifth | 18½ out |
| Saturday, August 17 |
| » Defeated Indians (58-64), 10-3 | Fenway Park (36-25) | 59-61 | Won 2 |
| » Starters: Barry Latman vs Bill Monbouquette | Fifth | 17½ out |
| Sunday, August 18 |
| » Lost to Indians (59-64), 7-4 | Fenway Park (36-26) | 59-62 | |
| » Starters: Mudcat Grant vs Dave Morehead | Fourth | 19 out |
| Monday, August 19 |
| » Lost to Indians (60-64), 8-3 | Fenway Park (36-27) | 59-63 | Lost 2 |
| » Starters: Pedro Ramos vs Arnold Earley | Fourth | 19½ out |
| Tuesday, August 20 |
| » Lost to White Sox (69-54), 10-2 | Fenway Park (36-28) | 59-64 | Lost 3 |
| » Starters: Juan Pizarro vs Bob Heffner | Sixth | 19½ out |
| Wednesday, August 21 |
| » Lost to White Sox (70-54), 7-1 | Fenway Park (36-29) | 59-65 | Lost 4 |
| » Starters: Gary Peters vs Bill Monbouquette | Sixth | 21 out |
| Thursday, August 22 |
| » Defeated White Sox (70-55), 11-2 | Fenway Park (37-29) | 60-65 | |
| » Starters: Joe Horlen vs Dave Morehead | Sixth | 20 out |
| Friday, August 23 |
| » Defeated Indians (62-67), 3-2 | Cleveland Stadium (3-3) | 61-65 | Won 2 |
| » Starters: Earl Wilson vs Pedro Ramos | Fifth | 20 out |
| Saturday, August 24 |
| » Lost to Indians (63-67), 6-2 | Cleveland Stadium (3-4) | 61-66 | |
| » Starters: Bob Turley vs Dick Donovan | Fifth | 21 out |
| Sunday, August 25 |
| » Defeated Indians (63-68), 8-3 | Cleveland Stadium (4-4) | 62-66 | |
| » Starters: Bill Monbouquette vs Barry Latman | Sixth | 21 out |
| » Lost to Indians (64-68), 2-1 | Cleveland Stadium (4-5) | 62-67 | |
| » Starters: Bob Heffner vs Jack Kralick | Sixth | 21 out |
| Tuesday, August 27 |
| » Lost to Yankees (84-46), 5-0 | Yankee Stadium (1-5) | 62-68 | Lost 2 |
| » Starters: Chet Nichols vs Jim Bouton | Sixth | 23 out |
| » Lost to Yankees (85-46), 3-0 | Yankee Stadium (1-6) | 62-69 | Lost 3 |
| » Starters: Dave Morehead vs Ralph Terry | Sixth | 23 out |
| Wednesday, August 28 |
| » Lost to Yankees (86-46), 4-1 | Yankee Stadium (1-7) | 62-70 | Lost 4 |
| » Starters: Earl Wilson vs Whitey Ford | Seventh | 24 out |
| Thursday, August 29 |
| » Defeated Yankees (86-47), 4-3 | Yankee Stadium (2-7) | 63-70 | |
| » Starters: Bill Monbouquette vs Stan Williams | Sixth | 23 out |
| Friday, August 30 |
| » Lost to Senators (49-85), 7-0 | Fenway Park (37-30) | 63-71 | |
| » Starters: Claude Osteen vs Bob Heffner | Seventh | 24 out |
| Saturday, August 31 |
| » Defeated Senators (49-86), 5-4 | Fenway Park (38-30) | 64-71 | |
| » Starters: Steve Ridzik vs Bob Turley | Sixth | 24 out |
| Sunday, September 1 |
| » Defeated Senators (49-87), 4-3 | Fenway Park (39-30) | 65-71 | Won 2 |
| » Starters: Bennie Daniels vs Earl Wilson | Seventh | 24 out |
| Monday, September 2 |
| » Defeated Orioles (73-65), 4-3 | Fenway Park (40-30) | 66-71 | Won 3 |
| » Starters: Milt Pappas vs Bill Monbouquette | Fifth | 23 out |
| » Defeated Orioles (73-66), 2-0 | Fenway Park (41-30) | 67-71 | Won 4 |
| » Starters: Dave McNally vs Bob Heffner | Fifth | 23 out |
| Tuesday, September 3 |
| » Lost to Orioles (74-66), 4-3 | Fenway Park (41-31) | 67-72 | |
| » Starters: Steve Barber vs Dave Morehead | Sixth | 23 out |
| Wednesday, September 4 |
| » Lost to Tigers (68-70), 6-1 | Fenway Park (41-32) | 67-73 | Lost 2 |
| » Starters: Phil Regan vs Bob Turley | Sixth | 24 out |
| Thursday, September 5 |
| » Lost to Tigers (69-70), 5-2 | Fenway Park (41-33) | 67-74 | Lost 3 |
| » Starters: Bob Anderson vs Earl Wilson | Seventh | 25 out |
| Friday, September 6 |
| » Lost to Orioles (76-66), 6-4 | Memorial Stadium (3-3) | 67-75 | Lost 4 |
| » Starters: Bill Monbouquette vs Milt Pappas | Seventh | 26½ out |
| » Lost to Orioles (77-66), 4-2 | Memorial Stadium (3-4) | 67-76 | Lost 5 |
| » Starters: Bob Heffner vs Mike McCormick | Seventh | 26½ out |
| Saturday, September 7 |
| » Defeated Orioles (77-67), 4-1 | Memorial Stadium (4-4) | 68-76 | |
| » Starters: Dave Morehead vs Dave McNally | Seventh | 26½ out |
| » Major-league debuts: Sam Bowens (Orioles) |
| Sunday, September 8 |
| » Defeated Orioles (77-68), 6-3 | Memorial Stadium (5-4) | 69-76 | Won 2 |
| » Starters: Gene Conley vs Steve Barber | Seventh | 26½ out |
| Monday, September 9 |
| » Defeated Angels (64-82), 5-2 | Dodger Stadium (4-2) | 70-76 | Won 3 |
| » Starters: Earl Wilson vs Dean Chance | Sixth | 25½ out |
| Tuesday, September 10 |
| » Lost to Angels (65-82), 6-5 | Dodger Stadium (4-3) | 70-77 | |
| » Starters: Bill Monbouquette vs Bo Belinsky | Sixth | 25½ out |
| Wednesday, September 11 |
| » Lost to Angels (66-82), 4-1 | Dodger Stadium (4-4) | 70-78 | Lost 2 |
| » Starters: Bob Heffner vs Aubrey Gatewood | Sixth | 26½ out |
| » Major-league debuts: Aubrey Gatewood (Angels) |
| Thursday, September 12 |
| » Lost to Angels (67-82), 2-0 | Dodger Stadium (4-5) | 70-79 | Lost 3 |
| » Starters: Dave Morehead vs Don Lee | Sixth | 27½ out |
| Friday, September 13 |
| » Defeated Athletics (67-81), 7-3 | Municipal Stadium (3-4) | 71-79 | |
| » Starters: Earl Wilson vs Dave Wickersham | Fifth | 27½ out |
| Saturday, September 14 |
| » Defeated Athletics (67-82), 6-4 | Municipal Stadium (4-4) | 72-79 | Won 2 |
| » Starters: Bill Monbouquette vs Orlando Pena | Sixth | 27 out |
| Sunday, September 15 |
| » Defeated Athletics (67-83), 5-3 | Municipal Stadium (5-4) | 73-79 | Won 3 |
| » Starters: Pete Smith vs Diego Segui | Sixth | 27 out |
| Tuesday, September 17 |
| » Lost to White Sox (86-65), 2-1 | Comiskey Park I (2-5) | 73-80 | |
| » Starters: Bob Heffner vs Joe Horlen | Sixth | 27 out |
| Wednesday, September 18 |
| » Lost to White Sox (87-65), 8-3 | Comiskey Park I (2-6) | 73-81 |
