| Wednesday, January 2 |
| Former Pirate Al Mamaux dies in Santa Monica, CA at the age of 69. |
| Sunday, January 20 |
| Future Pirate Cecil Espy is born in San Diego, CA. |
| Tuesday, January 29 |
| Former Pirate Lee Meadows dies in Daytona Beach, FL at the age of 69. |
| Saturday, February 9 |
| Former Pirate Ray Starr dies in Baylis, IL at the age of 57. |
| Friday, February 15 |
| Future Pirate Barry Jones is born in Centerville, IN. |
| Wednesday, February 20 |
| Former Pirate Bill Hinchman dies in Columbus, OH at the age of 80. |
| Saturday, February 23 |
| Future Pirate Bobby Bonilla is born in Bronx, NY. |
| Saturday, March 9 |
| Future Pirate Terry Mulholland is born in Uniontown, PA. |
| Sunday, March 10 |
| Future Pirate John Cangelosi is born in Brooklyn, NY. |
| Thursday, March 21 |
| Future Pirate Shawon Dunston is born in Brooklyn, NY. |
| Monday, April 8 |
| » Lost to Reds (1-0), 5-2 | Crosley Field (0-1) | 0-1 | |
| » Starters: Earl Francis vs Jim O'Toole | Third | 1 out |
| » Major-league debuts: Pete Rose (Reds) |
| Tuesday, April 9 |
| » Defeated Braves (0-1), 3-2 | Forbes Field (1-0) | 1-1 | |
| » Starters: Lew Burdette vs Bob Friend | Second | ½ out |
| Wednesday, April 10 |
| » Defeated Braves (0-2), 3-2 | Forbes Field (2-0) | 2-1 | Won 2 |
| » Starters: Bob Shaw vs Don Cardwell | Second | ½ out |
| Saturday, April 13 |
| » Defeated Reds (1-3), 12-4 | Crosley Field (1-1) | 3-1 | Won 3 |
| » Starters: Bob Friend vs Jim O'Toole | Third | 1 out |
| Sunday, April 14 |
| » Defeated Reds (1-4), 1-0 | Crosley Field (2-1) | 4-1 | Won 4 |
| » Starters: Al McBean vs Joey Jay | First | -- |
| Tuesday, April 16 |
| » Lost to Cardinals (4-2), 4-3 | Sportsman's Park III (0-1) | 4-2 | |
| » Starters: Earl Francis vs Bob Gibson | Third | 1 out |
| » Major-league debuts: Phil Gagliano (Cardinals) |
| Wednesday, April 17 |
| » Lost to Cardinals (5-2), 7-3 | Sportsman's Park III (0-2) | 4-3 | Lost 2 |
| » Starters: Don Cardwell vs Ray Washburn | Third | 1½ out |
| Thursday, April 18 |
| » Defeated Cardinals (5-3), 3-2 | Sportsman's Park III (1-2) | 5-3 | |
| » Starters: Don Schwall vs Ernie Broglio | Third | 1½ out |
| Saturday, April 20 |
| » Defeated Reds (3-5), 4-2 | Forbes Field (3-0) | 6-3 | Won 2 |
| » Starters: Joey Jay vs Bob Friend | Second | ½ out |
| Sunday, April 21 |
| » Lost to Reds (4-5), 8-3 | Forbes Field (3-1) | 6-4 | |
| » Starters: Jim Maloney vs Al McBean | Second | 1 out |
| Monday, April 22 |
| » Defeated Cubs (6-7), 2-0 | Forbes Field (4-1) | 7-4 | |
| » Starters: Glen Hobbie vs Earl Francis | First | -- |
| Tuesday, April 23 |
| » Lost to Cubs (7-7), 7-2 | Forbes Field (4-2) | 7-5 | |
| » Starters: Larry Jackson vs Don Cardwell | Second | 1 out |
| Wednesday, April 24 |
| » Defeated Phillies (7-7), 6-4 | Shibe Park (1-0) | 8-5 | |
| » Starters: Bob Friend vs Chris Short | Second | 1 out |
| Friday, April 26 |
| » Defeated Mets (6-10), 5-2 | Forbes Field (5-2) | 9-5 | Won 2 |
| » Starters: Al Jackson vs Al McBean | Second | 1½ out |
| Saturday, April 27 |
| » Defeated Mets (6-11), 2-1 | Forbes Field (6-2) | 10-5 | Won 3 |
| » Starters: Jay Hook vs Joe Gibbon | Second | 1½ out |
| Sunday, April 28 |
| » Defeated Mets (6-12), 3-2 | Forbes Field (7-2) | 11-5 | Won 4 |
| » Starters: Galen Cisco vs Don Schwall | First | -- |
| Wednesday, May 1 |
| » Lost to Giants (12-9), 5-1 | Forbes Field (7-3) | 11-6 | |
| » Starters: Jack Sanford vs Bob Friend | Second | 2 out |
| Thursday, May 2 |
| » Lost to Giants (13-9), 2-1 | Forbes Field (7-4) | 11-7 | Lost 2 |
| » Starters: Juan Marichal vs Don Cardwell | Second | 2 out |
| Friday, May 3 |
| » Defeated Dodgers (11-12), 13-2 | Forbes Field (8-4) | 12-7 | |
| » Starters: Larry Sherry vs Al McBean | Second | 2 out |
| Saturday, May 4 |
| » Defeated Dodgers (11-13), 5-0 | Forbes Field (9-4) | 13-7 | Won 2 |
| » Starters: Bob Miller vs Don Schwall | First | -- |
| Sunday, May 5 |
| » Lost to Dodgers (12-13), 7-3 | Forbes Field (9-5) | 13-8 | |
| » Starters: Pete Richert vs Vern Law | First | -- |
| Monday, May 6 |
| » Defeated Dodgers (12-14), 7-4 | Forbes Field (10-5) | 14-8 | |
| » Starters: Don Drysdale vs Bob Friend | First | -- |
| Tuesday, May 7 |
| » Lost to Cubs (14-11), 5-4 | Wrigley Field (0-1) | 14-9 | |
| » Starters: Don Cardwell vs Larry Jackson | Second | 2 out |
| Wednesday, May 8 |
| » Lost to Cubs (15-11), 9-5 | Wrigley Field (0-2) | 14-10 | Lost 2 |
| » Starters: Al McBean vs Bob Buhl | Second | 2 out |
| Thursday, May 9 |
| » Lost to Cubs (16-11), 3-1 | Wrigley Field (0-3) | 14-11 | Lost 3 |
| » Starters: Don Schwall vs Dick Ellsworth | Fourth | 3 out |
| Friday, May 10 |
| » Lost to Cardinals (18-12), 1-0 | Forbes Field (10-6) | 14-12 | Lost 4 |
| » Starters: Curt Simmons vs Bob Friend | Fourth | 3 out |
| Saturday, May 11 |
| » Defeated Cardinals (18-13), 3-2 | Forbes Field (11-6) | 15-12 | |
| » Starters: Ray Washburn vs Vern Law | Third | 2 out |
| Sunday, May 12 |
| » Lost to Cardinals (19-13), 2-1 | Forbes Field (11-7) | 15-13 | |
| » Starters: Ernie Broglio vs Joe Gibbon | Third | 1½ out |
| » Defeated Cardinals (19-14), 4-3 | Forbes Field (12-7) | 16-13 | |
| » Starters: Ray Sadecki vs Earl Francis | Third | 1½ out |
| Tuesday, May 14 |
| » Lost to Giants (20-13), 3-1 | Candlestick Park (0-1) | 16-14 | |
| » Starters: Bob Friend vs Jack Sanford | Third | 2½ out |
| Wednesday, May 15 |
| » Lost to Giants (21-13), 4-3 | Candlestick Park (0-2) | 16-15 | Lost 2 |
| » Starters: Don Cardwell vs Juan Marichal | Fourth | 3½ out |
| Thursday, May 16 |
| » Lost to Dodgers (19-16), 1-0 | Dodger Stadium (0-1) | 16-16 | Lost 3 |
| » Starters: Don Schwall vs Johnny Podres | Fifth | 4½ out |
| Friday, May 17 |
| » Lost to Dodgers (20-16), 9-3 | Dodger Stadium (0-2) | 16-17 | Lost 4 |
| » Starters: Joe Gibbon vs Bob Miller | Fifth | 5½ out |
| Saturday, May 18 |
| » Lost to Dodgers (21-16), 6-4 | Dodger Stadium (0-3) | 16-18 | Lost 5 |
| » Starters: Vern Law vs Don Drysdale | Sixth | 5½ out |
| Sunday, May 19 |
| » Defeated Astros (17-22), 5-0 | Colt Stadium (1-0) | 17-18 | |
| » Starters: Bob Friend vs Turk Farrell | Sixth | 5 out |
| Monday, May 20 |
| » Lost to Astros (18-22), 2-0 | Colt Stadium (1-1) | 17-19 | |
| » Starters: Don Cardwell vs Dick Drott | Seventh | 5½ out |
| Tuesday, May 21 |
| » Defeated Astros (18-23), 6-5 | Colt Stadium (2-1) | 18-19 | |
| » Starters: Don Schwall vs Ken Johnson | Sixth | 5½ out |
| Wednesday, May 22 |
| » Defeated Astros (18-24), 4-3 | Colt Stadium (3-1) | 19-19 | Won 2 |
| » Starters: Vern Law vs Don Nottebart | Sixth | 5½ out |
| Friday, May 24 |
| » Defeated Braves (19-23), 7-2 | County Stadium (1-0) | 20-19 | Won 3 |
| » Starters: Bob Friend vs Warren Spahn | Fourth | 5½ out |
| Saturday, May 25 |
| » Lost to Braves (20-23), 1-0 | County Stadium (1-1) | 20-20 | |
| » Starters: Joe Gibbon vs Bob Shaw | Fifth | 6½ out |
| Sunday, May 26 |
| » Defeated Braves (20-24), 5-2 | County Stadium (2-1) | 21-20 | |
| » Starters: Don Schwall vs Lew Burdette | Fifth | 5½ out |
| » Major-league debuts: Ron Brand (Pirates) |
| Tuesday, May 28 |
| » Lost to Phillies (21-23), 5-1 | Forbes Field (12-8) | 21-21 | |
| » Starters: Cal McLish vs Bob Friend | Fifth | 5½ out |
| Thursday, May 30 |
| » Defeated Phillies (21-24), 7-1 | Forbes Field (13-8) | 22-21 | |
| » Starters: Art Mahaffey vs Don Cardwell | Fifth | 6½ out |
| » Lost to Phillies (22-24), 6-5 | Forbes Field (13-9) | 22-22 | |
| » Starters: Ray Culp vs Joe Gibbon | Fifth | 6½ out |
| Friday, May 31 |
| » Defeated Mets (18-31), 2-0 | Polo Grounds V (1-0) | 23-22 | |
| » Starters: Don Schwall vs Carl Willey | Fifth | 5½ out |
| Saturday, June 1 |
| » Defeated Mets (18-32), 10-1 | Polo Grounds V (2-0) | 24-22 | Won 2 |
| » Starters: Bob Friend vs Galen Cisco | Fifth | 4½ out |
| Sunday, June 2 |
| » Lost to Mets (19-32), 2-1 | Polo Grounds V (2-1) | 24-23 | |
| » Starters: Vern Law vs Roger Craig | Sixth | 6 out |
| » Lost to Mets (20-32), 4-3 | Polo Grounds V (2-2) | 24-24 | Lost 2 |
| » Starters: Al McBean vs Tracy Stallard | Sixth | 6 out |
| Wednesday, June 5 |
| » Defeated Reds (24-24), 5-4 | Forbes Field (14-9) | 25-24 | |
| » Starters: Joe Nuxhall vs Don Cardwell | Fourth | 3½ out |
| » Defeated Reds (24-25), 4-3 | Forbes Field (15-9) | 26-24 | Won 2 |
| » Starters: Bob Purkey vs Bob Friend | Fourth | 3½ out |
| Thursday, June 6 |
| » Lost to Reds (25-25), 7-5 | Forbes Field (15-10) | 26-25 | |
| » Starters: Jim Maloney vs Joe Gibbon | Fourth | 4 out |
| » Lost to Reds (26-25), 10-5 | Forbes Field (15-11) | 26-26 | Lost 2 |
| » Starters: Joey Jay vs Don Schwall | Fourth | 4 out |
| Friday, June 7 |
| » Lost to Braves (25-27), 9-5 | Forbes Field (15-12) | 26-27 | Lost 3 |
| » Starters: Bob Shaw vs Al McBean | Fourth | 4 out |
| Saturday, June 8 |
| » Defeated Braves (25-28), 6-4 | Forbes Field (16-12) | 27-27 | |
| » Starters: Lew Burdette vs Vern Law | Fifth | 4 out |
| Future Pirate Scott Ruskin is born in Jacksonville, FL. Former Pirate Earl Smith dies in Little Rock, AR at the age of 67 |
| Sunday, June 9 |
| » Defeated Braves (25-29), 4-0 | Forbes Field (17-12) | 28-27 | Won 2 |
| » Starters: Denny Lemaster vs Bob Friend | Fifth | 4½ out |
| » Lost to Braves (26-29), 5-3 | Forbes Field (17-13) | 28-28 | |
| » Starters: Warren Spahn vs Don Cardwell | Fifth | 4½ out |
| Monday, June 10 |
| Former Pirate Mike Simon dies in Los Angeles, CA at the age of 81. |
| Tuesday, June 11 |
| » Lost to Cardinals (34-25), 3-1 | Forbes Field (17-14) | 28-29 | Lost 2 |
| » Starters: Bob Gibson vs Don Schwall | Sixth | 5 out |
| Wednesday, June 12 |
| » Lost to Reds (30-27), 3-0 | Crosley Field (2-2) | 28-30 | Lost 3 |
| » Starters: Earl Francis vs Jim O'Toole | Fifth | 5 out |
| Thursday, June 13 |
| » Lost to Reds (31-27), 4-2 | Crosley Field (2-3) | 28-31 | Lost 4 |
| » Starters: Don Cardwell vs John Tsitouris | Fifth | 6 out |
| Friday, June 14 |
| » Lost to Cardinals (36-26), 5-2 | Sportsman's Park III (1-3) | 28-32 | Lost 5 |
| » Starters: Bob Friend vs Ray Washburn | Sixth | 7 out |
| Sunday, June 16 |
| » Defeated Cardinals (36-27), 4-3 | Sportsman's Park III (2-3) | 29-32 | |
| » Starters: Don Schwall vs Bob Gibson | Seventh | 7½ out |
| » Lost to Cardinals (37-27), 11-7 | Sportsman's Park III (2-4) | 29-33 | |
| » Starters: Vern Law vs Curt Simmons | Seventh | 7½ out |
| Monday, June 17 |
| » Defeated Braves (30-33), 9-3 | County Stadium (3-1) | 30-33 | |
| » Starters: Don Cardwell vs Ron Piche | Sixth | 7 out |
| Tuesday, June 18 |
| » Lost to Braves (31-33), 7-5 | County Stadium (3-2) | 30-34 | |
| » Starters: Bob Friend vs Warren Spahn | Seventh | 8 out |
| Wednesday, June 19 |
| » Defeated Braves (31-34), 6-2 | County Stadium (4-2) | 31-34 | |
| » Starters: Earl Francis vs Bob Sadowski | Sixth | 8 out |
| » Major-league debuts: Bob Sadowski (Braves) |
| Thursday, June 20 |
| » Lost to Braves (32-34), 2-1 | County Stadium (4-3) | 31-35 | |
| » Starters: Don Schwall vs Denny Lemaster | Seventh | 8½ out |
| Friday, June 21 |
| » Lost to Cubs (38-31), 6-5 | Wrigley Field (0-4) | 31-36 | Lost 2 |
| » Starters: Don Cardwell vs Bob Buhl | Seventh | 8½ out |
| Saturday, June 22 |
| » Defeated Cubs (38-32), 3-0 | Wrigley Field (1-4) | 32-36 | |
| » Starters: Bob Friend vs Dick Ellsworth | Sixth | 8½ out |
| Sunday, June 23 |
| » Defeated Cubs (38-33), 7-6 | Wrigley Field (2-4) | 33-36 | Won 2 |
| » Starters: Vern Law vs Glen Hobbie | Seventh | 7½ out |
| Tuesday, June 25 |
| » Lost to Phillies (32-40), 5-4 | Forbes Field (17-15) | 33-37 | |
| » Starters: Art Mahaffey vs Earl Francis | Seventh | 8 out |
| Wednesday, June 26 |
| » Lost to Phillies (33-40), 6-2 | Forbes Field (17-16) | 33-38 | Lost 2 |
| » Starters: Cal McLish vs Bob Friend | Seventh | 9 out |
| Thursday, June 27 |
| » Lost to Phillies (34-40), 13-4 | Forbes Field (17-17) | 33-39 | Lost 3 |
| » Starters: Ray Culp vs Don Cardwell | Eighth | 9½ out |
| Friday, June 28 |
| » Defeated Mets (29-46), 3-1 | Forbes Field (18-17) | 34-39 | |
| » Starters: Roger Craig vs Joe Gibbon | Sixth | 9½ out |
| Saturday, June 29 |
| » Defeated Mets (29-47), 4-3 | Forbes Field (19-17) | 35-39 | Won 2 |
| » Starters: Carl Willey vs Harvey Haddix | Seventh | 9½ out |
| Sunday, June 30 |
| » Defeated Mets (29-48), 3-0 | Forbes Field (20-17) | 36-39 | Won 3 |
| » Starters: Tracy Stallard vs Bob Friend | Seventh | 8½ out |
| Monday, July 1 |
| » Defeated Phillies (35-42), 2-1 | Shibe Park (2-0) | 37-39 | Won 4 |
| » Starters: Don Cardwell vs Ray Culp | Seventh | 8 out |
| » Lost to Phillies (36-42), 8-1 | Shibe Park (2-1) | 37-40 | |
| » Starters: Earl Francis vs Cal McLish | Seventh | 8 out |
| Tuesday, July 2 |
| » Defeated Phillies (36-43), 3-2 | Shibe Park (3-1) | 38-40 | |
| » Starters: Vern Law vs Dallas Green | Seventh | 7½ out |
| Thursday, July 4 |
| » Lost to Phillies (37-43), 1-0 | Shibe Park (3-2) | 38-41 | |
| » Starters: Bob Friend vs Art Mahaffey | Seventh | 9½ out |
| » Lost to Phillies (38-43), 5-1 | Shibe Park (3-3) | 38-42 | Lost 2 |
| » Starters: Joe Gibbon vs Ryne Duren | Seventh | 9½ out |
| Friday, July 5 |
| » Defeated Mets (29-53), 3-1 | Polo Grounds V (3-2) | 39-42 | |
| » Starters: Don Cardwell vs Tracy Stallard | Seventh | 9½ out |
| Saturday, July 6 |
| » Defeated Mets (29-54), 11-3 | Polo Grounds V (4-2) | 40-42 | Won 2 |
| » Starters: Don Schwall vs Al Jackson | Seventh | 8½ out |
| Sunday, July 7 |
| » Defeated Mets (29-55), 11-5 | Polo Grounds V (5-2) | 41-42 | Won 3 |
| » Starters: Vern Law vs Jay Hook | Seventh | 9 out |
| Wednesday, July 10 |
| » Lost to Astros (34-54), 2-0 | Forbes Field (20-18) | 41-43 | |
| » Starters: Ken Johnson vs Bob Friend | Seventh | 10 out |
| » Major-league debuts: Jimmy Wynn (Astros) |
| Thursday, July 11 |
| » Defeated Astros (34-55), 3-0 | Forbes Field (21-18) | 42-43 | |
| » Starters: Turk Farrell vs Don Cardwell | Seventh | 10 out |
| Friday, July 12 |
| » Defeated Astros (34-56), 2-1 | Forbes Field (22-18) | 43-43 | Won 2 |
| » Starters: Bob Bruce vs Don Schwall | Seventh | 10 out |
| Saturday, July 13 |
| » Defeated Astros (34-57), 3-0 | Forbes Field (23-18) | 44-43 | Won 3 |
| » Starters: Dick Drott vs Vern Law | Seventh | 10 out |
| Monday, July 15 |
| » Defeated Giants (49-41), 2-1 | Forbes Field (24-18) | 45-43 | Won 4 |
| » Starters: Juan Marichal vs Bob Friend | Fifth | 9 out |
| » Defeated Giants (49-42), 4-1 | Forbes Field (25-18) | 46-43 | Won 5 |
| » Starters: Billy O'Dell vs Joe Gibbon | Fifth | 9 out |
| Tuesday, July 16 |
| » Lost to Giants (50-42), 3-2 | Forbes Field (25-19) | 46-44 | |
| » Starters: Bobby Bolin vs Don Cardwell | Sixth | 9 out |
| » Defeated Giants (50-43), 3-2 | Forbes Field (26-19) | 47-44 | |
| » Starters: Jack Sanford vs Don Schwall | Sixth | 9 out |
| Wednesday, July 17 |
| » Lost to Dodgers (57-35), 3-2 | Forbes Field (26-20) | 47-45 | |
| » Starters: Bob Miller vs Vern Law | Sixth | 10 out |
| Thursday, July 18 |
| » Lost to Dodgers (58-35), 10-5 | Forbes Field (26-21) | 47-46 | Lost 2 |
| » Starters: Johnny Podres vs Earl Francis | Sixth | 11 out |
| Friday, July 19 |
| » Defeated Cubs (51-42), 9-4 | Forbes Field (27-21) | 48-46 | |
| » Starters: Dick Ellsworth vs Bob Friend | Fifth | 11 out |
| Future Pirate Vicente Palacios is born in Veracruz, Mexico. |
| Sunday, July 21 |
| » Lost to Cubs (52-42), 5-1 | Forbes Field (27-22) | 48-47 | |
| » Starters: Paul Toth vs Don Cardwell | Sixth | 10½ out |
| » Defeated Cubs (52-43), 6-5 | Forbes Field (28-22) | 49-47 | |
| » Starters: Dick LeMay vs Don Schwall | Sixth | 10½ out |
| Monday, July 22 |
| Future Pirate Denny Gonzalez is born in Sabana Grande De Boya, D.R. |
| Tuesday, July 23 |
| » Lost to Dodgers (61-37), 6-0 | Dodger Stadium (0-4) | 49-48 | |
| » Starters: Bob Friend vs Johnny Podres | Sixth | 11½ out |
| Wednesday, July 24 |
| » Lost to Dodgers (62-37), 5-1 | Dodger Stadium (0-5) | 49-49 | Lost 2 |
| » Starters: Earl Francis vs Don Drysdale | Eighth | 12½ out |
| Thursday, July 25 |
| » Defeated Dodgers (62-38), 6-2 | Dodger Stadium (1-5) | 50-49 | |
| » Starters: Joe Gibbon vs Sandy Koufax | Seventh | 11½ out |
| Friday, July 26 |
| » Lost to Giants (56-46), 6-4 | Candlestick Park (0-3) | 50-50 | |
| » Starters: Don Cardwell vs Billy O'Dell | Seventh | 11½ out |
| Saturday, July 27 |
| » Lost to Giants (57-46), 3-1 | Candlestick Park (0-4) | 50-51 | Lost 2 |
| » Starters: Bob Friend vs Juan Marichal | Eighth | 11½ out |
| Sunday, July 28 |
| » Lost to Giants (58-46), 3-1 | Candlestick Park (0-5) | 50-52 | Lost 3 |
| » Starters: Don Schwall vs Jack Sanford | Seventh | 11½ out |
| Monday, July 29 |
| » Lost to Giants (59-46), 5-4 | Candlestick Park (0-6) | 50-53 | Lost 4 |
| » Starters: Earl Francis vs Gaylord Perry | Eighth | 12½ out |
| Future Pirate Tommy Gregg is born in Boone, NC. |
| Tuesday, July 30 |
| » Defeated Astros (41-66), 8-1 | Colt Stadium (4-1) | 51-53 | |
| » Starters: Joe Gibbon vs Hal Brown | Eighth | 11½ out |
| Wednesday, July 31 |
| » Defeated Astros (41-67), 6-3 | Colt Stadium (5-1) | 52-53 | Won 2 |
| » Starters: Bob Friend vs Don Nottebart | Eighth | 11½ out |
| Friday, August 2 |
| » Lost to Reds (58-52), 3-0 | Crosley Field (2-4) | 52-54 | |
| » Starters: Don Cardwell vs Jim Maloney | Eighth | 11½ out |
| Saturday, August 3 |
| » Defeated Reds (58-53), 5-4 | Crosley Field (3-4) | 53-54 | |
| » Starters: Don Schwall vs John Tsitouris | Eighth | 11½ out |
| Sunday, August 4 |
| » Lost to Reds (59-53), 5-2 | Crosley Field (3-5) | 53-55 | |
| » Starters: Bob Friend vs Bob Purkey | Eighth | 13 out |
| » Lost to Reds (60-53), 4-1 | Crosley Field (3-6) | 53-56 | Lost 2 |
| » Starters: Joe Gibbon vs Joe Nuxhall | Eighth | 13 out |
| Tuesday, August 6 |
| » Defeated Braves (57-56), 3-0 | Forbes Field (29-22) | 54-56 | |
| » Starters: Denny Lemaster vs Don Cardwell | Seventh | 13 out |
| Wednesday, August 7 |
| » Defeated Braves (57-57), 5-4 | Forbes Field (30-22) | 55-56 | Won 2 |
| » Starters: Hank Fischer vs Don Schwall | Seventh | 13 out |
| Thursday, August 8 |
| » Defeated Braves (57-58), 1-0 | Forbes Field (31-22) | 56-56 | Won 3 |
| » Starters: Bob Sadowski vs Bob Friend | Seventh | 12 out |
| Friday, August 9 |
| » Lost to Astros (45-70), 7-6 | Forbes Field (31-23) | 56-57 | |
| » Starters: Ken Johnson vs Joe Gibbon | Seventh | 11½ out |
| » Defeated Astros (45-71), 7-6 | Forbes Field (32-23) | 57-57 | |
| » Starters: Bob Bruce vs Earl Francis | Seventh | 11½ out |
| Saturday, August 10 |
| » Defeated Astros (45-72), 3-2 | Forbes Field (33-23) | 58-57 | Won 2 |
| » Starters: Don Nottebart vs Don Cardwell | Seventh | 11½ out |
| Sunday, August 11 |
| » Defeated Astros (45-73), 2-1 | Forbes Field (34-23) | 59-57 | Won 3 |
| » Starters: Hal Brown vs Joe Gibbon | Sixth | 10½ out |
| Monday, August 12 |
| » Defeated Astros (45-74), 4-2 | Forbes Field (35-23) | 60-57 | Won 4 |
| » Starters: Turk Farrell vs Bob Friend | Seventh | 10 out |
| Tuesday, August 13 |
| Future Pirate Jeff Ballard is born in Billings, MT. |
| Wednesday, August 14 |
| » Lost to Mets (39-79), 4-2 | Polo Grounds V (5-3) | 60-58 | |
| » Starters: Don Schwall vs Al Jackson | Eighth | 9½ out |
| Thursday, August 15 |
| » Defeated Mets (39-80), 8-2 | Polo Grounds V (6-3) | 61-58 | |
| » Starters: Don Cardwell vs Galen Cisco | Seventh | 9½ out |
| Friday, August 16 |
| » Lost to Phillies (65-58), 3-0 | Forbes Field (35-24) | 61-59 | |
| » Starters: Chris Short vs Joe Gibbon | Eighth | 10½ out |
| Saturday, August 17 |
| » Lost to Phillies (66-58), 5-3 | Forbes Field (35-25) | 61-60 | Lost 2 |
| » Starters: Dallas Green vs Bob Friend | Seventh | 11½ out |
| Sunday, August 18 |
| » Lost to Phillies (67-58), 3-1 | Forbes Field (35-26) | 61-61 | Lost 3 |
| » Starters: Ray Culp vs Don Schwall | Seventh | 13 out |
| Tuesday, August 20 |
| » Defeated Cubs (64-60), 5-3 | Wrigley Field (3-4) | 62-61 | |
| » Starters: Don Cardwell vs Bob Buhl | Eighth | 13 out |
| Wednesday, August 21 |
| » Defeated Cubs (64-61), 7-6 | Wrigley Field (4-4) | 63-61 | Won 2 |
| » Starters: Joe Gibbon vs Dick Ellsworth | Eighth | 13 out |
| Thursday, August 22 |
| » Defeated Cubs (64-62), 9-3 | Wrigley Field (5-4) | 64-61 | Won 3 |
| » Starters: Bob Friend vs Larry Jackson | Seventh | 12 out |
| Friday, August 23 |
| » Lost to Phillies (70-59), 4-2 | Shibe Park (3-4) | 64-62 | |
| » Starters: Don Schwall vs Dennis Bennett | Eighth | 12 out |
| Saturday, August 24 |
| » Defeated Phillies (70-60), 7-0 | Shibe Park (4-4) | 65-62 | |
| » Starters: Don Cardwell vs Chris Short | Sixth | 11 out |
| Sunday, August 25 |
| » Lost to Phillies (71-60), 4-2 | Shibe Park (4-5) | 65-63 | |
| » Starters: Bob Veale vs Cal McLish | Seventh | 12 out |
| Tuesday, August 27 |
| » Defeated Mets (41-89), 2-1 | Forbes Field (36-26) | 66-63 | |
| » Starters: Grover Powell vs Bob Friend | Seventh | 11½ out |
| Wednesday, August 28 |
| » Defeated Mets (41-90), 7-2 | Forbes Field (37-26) | 67-63 | Won 2 |
| » Starters: Al Jackson vs Don Cardwell | Seventh | 10½ out |
| Thursday, August 29 |
| » Lost to Mets (42-90), 7-4 | Forbes Field (37-27) | 67-64 | |
| » Starters: Roger Craig vs Joe Gibbon | Eighth | 11½ out |
| Friday, August 30 |
| » Lost to Reds (72-65), 2-1 | Forbes Field (37-28) | 67-65 | Lost 2 |
| » Starters: Joe Nuxhall vs Don Schwall | Eighth | 12½ out |
| Saturday, August 31 |
| » Lost to Reds (73-65), 6-0 | Forbes Field (37-29) | 67-66 | Lost 3 |
| » Starters: Jim O'Toole vs Bob Friend | Eighth | 12½ out |
| Sunday, September 1 |
| » Defeated Reds (73-66), 6-4 | Forbes Field (38-29) | 68-66 | |
| » Starters: John Tsitouris vs Don Cardwell | Eighth | 12½ out |
| Monday, September 2 |
| » Lost to Cardinals (76-60), 6-1 | Sportsman's Park III (2-5) | 68-67 | |
| » Starters: Bob Veale vs Bob Gibson | Eighth | 14½ out |
| » Lost to Cardinals (77-60), 6-2 | Sportsman's Park III (2-6) | 68-68 | Lost 2 |
| » Starters: Joe Gibbon vs Ron Taylor | Eighth | 14½ out |
| Tuesday, September 3 |
| » Lost to Cardinals (78-60), 10-5 | Sportsman's Park III (2-7) | 68-69 | Lost 3 |
| » Starters: Tommie Sisk vs Ray Sadecki | Eighth | 15½ out |
| Wednesday, September 4 |
| » Lost to Braves (74-65), 1-0 | County Stadium (4-4) | 68-70 | Lost 4 |
| » Starters: Bob Friend vs Warren Spahn | Eighth | 15½ out |
| » Major-league debuts: Gene Alley (Pirates) |
| Thursday, September 5 |
| » Lost to Braves (75-65), 8-0 | County Stadium (4-5) | 68-71 | Lost 5 |
| » Starters: Tom Parsons vs Bob Sadowski | Seventh | 16½ out |
| » Major-league debuts: Tom Parsons (Pirates) |
| Friday, September 6 |
| » Lost to Cardinals (81-60), 5-1 | Forbes Field (38-30) | 68-72 | Lost 6 |
| » Starters: Bob Gibson vs Don Cardwell | Eighth | 17 out |
| » Defeated Cardinals (81-61), 5-0 | Forbes Field (39-30) | 69-72 | |
| » Starters: Ron Taylor vs Bob Veale | Eighth | 17 out |
| Saturday, September 7 |
| » Lost to Cardinals (82-61), 6-5 | Forbes Field (39-31) | 69-73 | |
| » Starters: Ray Sadecki vs Joe Gibbon | Eighth | 17 out |
| Sunday, September 8 |
| » Lost to Cardinals (83-61), 3-2 | Forbes Field (39-32) | 69-74 | Lost 2 |
| » Starters: Ernie Broglio vs Bob Friend | Eighth | 17 out |
| Monday, September 9 |
| » Major-league debuts: Woody Woodward (Braves) |
| Tuesday, September 10 |
| » Lost to Dodgers (87-57), 4-2 | Forbes Field (39-33) | 69-75 | Lost 3 |
| » Starters: Sandy Koufax vs Don Cardwell | Eighth | 18 out |
| Wednesday, September 11 |
| » Lost to Dodgers (88-57), 9-4 | Forbes Field (39-34) | 69-76 | Lost 4 |
| » Starters: Don Drysdale vs Bob Veale | Eighth | 19 out |
| Former Pirate Ham Hyatt dies in Liberty Lake, WA at the age of 79. |
| Thursday, September 12 |
| » Lost to Dodgers (89-57), 5-3 | Forbes Field (39-35) | 69-77 | Lost 5 |
| » Starters: Johnny Podres vs Bob Friend | Eighth | 20 out |
| Friday, September 13 |
| » Defeated Giants (79-69), 5-4 | Forbes Field (40-35) | 70-77 | |
| » Starters: Bobby Bolin vs Joe Gibbon | Eighth | 19½ out |
| Saturday, September 14 |
| » Lost to Giants (80-69), 7-3 | Forbes Field (40-36) | 70-78 | |
| » Starters: Jack Sanford vs Don Cardwell | Seventh | 20½ out |
| Sunday, September 15 |
| » Lost to Giants (81-69), 13-5 | Forbes Field (40-37) | 70-79 | Lost 2 |
| » Starters: Billy O'Dell vs Don Schwall | Eighth | 20½ out |
| Monday, September 16 |
| » Defeated Cubs (75-76), 1-0 | Forbes Field (41-37) | 71-79 | |
| » Starters: Larry Jackson vs Bob Veale | Eighth | 20½ out |
| Tuesday, September 17 |
| » Lost to Cubs (76-76), 3-1 | Forbes Field (41-38) | 71-80 | |
| » Starters: Bob Buhl vs Bob Friend | Eighth | 21 out |
| » Defeated Cubs (76-77), 4-3 | Forbes Field (42-38) | 72-80 | |
| » Starters: Glen Hobbie vs Tommie Sisk | Eighth | 21 out |
| Wednesday, September 18 |
| » Lost to Cubs (77-77), 2-1 | Forbes Field (42-39) | 72-81 | |
| » Starters: Cal Koonce vs Joe Gibbon | Eighth | 22 out |
| Friday, September 20 |
| » Lost to Dodgers (95-59), 2-0 | Dodger Stadium (1-6) | 72-82 | Lost 2 |
| » Starters: Don Cardwell vs Don Drysdale | Eighth | 23 out |
| Saturday, September 21 |
| » Lost to Dodgers (96-59), 5-3 | Dodger Stadium (1-7) | 72-83 | Lost 3 |
| » Starters: Bob Friend vs Sandy Koufax | Seventh | 24 out |
| Sunday, September 22 |
| » Defeated Dodgers (96-60), 4-0 | Dodger Stadium (2-7) | 73-83 | |
| » Starters: Bob Veale vs Johnny Podres | Eighth | 23 out |
| Tuesday, September 24 |
| » Lost to Astros (62-95), 3-2 | Colt Stadium (5-2) | 73-84 | |
| » Starters: Earl Francis vs Chris Zachary | Eighth | 24 out |
| Wednesday, September 25 |
| » Lost to Astros (63-95), 2-1 | Colt Stadium (5-3) | 73-85 | Lost 2 |
| » Starters: Tommie Sisk vs Ken Johnson | Eighth | 25 out |
| Thursday, September 26 |
| » Lost to Astros (64-95), 5-4 | Colt Stadium (5-4) | 73-86 | Lost 3 |
| » Starters: Tom Butters vs Larry Yellen | Seventh | 26 out |
| Friday, September 27 |
| » Defeated Giants (86-74), 8-3 | Candlestick Park (1-6) | 74-86 | |
| » Starters: Bob Veale vs Bobby Bolin | Seventh | 25 out |
| Saturday, September 28 |
| » Lost to Giants (87-74), 3-2 | Candlestick Park (1-7) | 74-87 | |
| » Starters: Joe Gibbon vs Juan Marichal | Seventh | 25 out |
| Sunday, September 29 |
| » Lost to Giants (88-74), 4-2 | Candlestick Park (1-8) | 74-88 | Lost 2 |
| » Starters: Tommie Sisk vs Jack Sanford | Eighth | 25 out |
| Wednesday, October 9 |
| Future Pirate Felix Fermin is born in Mao, D.R. |
| Thursday, October 17 |
| Future Pirate Ravelo Manzanillo is born in San Pedro de Macoris, D.R. |
| Saturday, October 26 |
| Former Pirate Newt Hunter dies in Columbus, OH at the age of 84. |
| Monday, November 11 |
| Future Pirate Rey Quinones is born in Rio Piedras, P.R. |
| Saturday, November 23 |
| Future Pirate Rich Sauveur is born in Arlington, VA. Future Pirate Dale Sveum is born in Richmond, CA. |
Game information provided by Retrosheet (www.retrosheet.org) |