| Sunday, January 6 |
| Future Oriole Norm Charlton is born in Fort Polk, LA. |
| Tuesday, January 8 |
| Future Oriole Shane Turner is born in Los Angeles, CA. |
| Monday, February 18 |
| Future Oriole Jeff McKnight is born in Conway, AR. |
| Saturday, February 23 |
| Future Oriole Bobby Bonilla is born in Bronx, NY. |
| Monday, April 8 |
| » Defeated Senators (0-1), 3-1 | Robert F. Kennedy Stadium (1-0) | 1-0 | |
| » Starters: Steve Barber vs Don Rudolph | First | -- |
| » Major-league debuts: Tom Brown (Senators) |
| Wednesday, April 10 |
| » Defeated Senators (0-2), 3-2 | Memorial Stadium (1-0) | 2-0 | Won 2 |
| » Starters: Claude Osteen vs Robin Roberts | First | -- |
| Future Oriole Mike Devereaux is born in Casper, WY. |
| Thursday, April 11 |
| » Defeated Yankees (2-1), 4-1 | Yankee Stadium (1-0) | 3-0 | Won 3 |
| » Starters: Milt Pappas vs Whitey Ford | First | -- |
| » Major-league debuts: Pedro Gonzales (Yankees) |
| Saturday, April 13 |
| » Lost to Yankees (3-1), 6-1 | Yankee Stadium (1-1) | 3-1 | |
| » Starters: Steve Barber vs Ralph Terry | First | -- |
| Sunday, April 14 |
| » Lost to Yankees (4-1), 5-1 | Yankee Stadium (1-2) | 3-2 | Lost 2 |
| » Starters: Chuck Estrada vs Stan Williams | Second | 1 out |
| » Major-league debuts: Buster Narum (Orioles) |
| Tuesday, April 16 |
| » Lost to Red Sox (3-3), 6-1 | Fenway Park (0-1) | 3-3 | Lost 3 |
| » Starters: Robin Roberts vs Bill Monbouquette | Second | 1 out |
| Wednesday, April 17 |
| » Defeated Red Sox (3-4), 5-4 | Fenway Park (1-1) | 4-3 | |
| » Starters: Steve Barber vs Earl Wilson | Third | 1 out |
| Friday, April 19 |
| » Defeated Indians (3-4), 8-5 | Memorial Stadium (2-0) | 5-3 | Won 2 |
| » Starters: Pedro Ramos vs Milt Pappas | Second | ½ out |
| Saturday, April 20 |
| » Defeated Indians (3-5), 8-1 | Memorial Stadium (3-0) | 6-3 | Won 3 |
| » Starters: Mudcat Grant vs Dave McNally | First | -- |
| Sunday, April 21 |
| » Defeated Indians (3-6), 7-0 | Memorial Stadium (4-0) | 7-3 | Won 4 |
| » Starters: Sam McDowell vs Steve Barber | First | -- |
| » Lost to Indians (4-6), 2-0 | Memorial Stadium (4-1) | 7-4 | |
| » Starters: Dick Donovan vs Robin Roberts | First | -- |
| Tuesday, April 23 |
| » Defeated Twins (4-9), 1-0 | Memorial Stadium (5-1) | 8-4 | |
| » Starters: Dick Stigman vs Milt Pappas | First | -- |
| Wednesday, April 24 |
| » Lost to Athletics (9-5), 5-0 | Memorial Stadium (5-2) | 8-5 | |
| » Starters: Orlando Pena vs Mike McCormick | Third | ½ out |
| Thursday, April 25 |
| » Defeated Athletics (9-6), 3-2 | Memorial Stadium (6-2) | 9-5 | |
| » Starters: Dave Wickersham vs Steve Barber | First | -- |
| Friday, April 26 |
| » Lost to Angels (8-8), 4-3 | Memorial Stadium (6-3) | 9-6 | |
| » Starters: Ken McBride vs Robin Roberts | Second | 2 out |
| Saturday, April 27 |
| » Defeated Angels (8-9), 4-2 | Memorial Stadium (7-3) | 10-6 | |
| » Starters: Bo Belinsky vs Dave McNally | First | -- |
| Sunday, April 28 |
| » Lost to Angels (9-9), 3-2 | Memorial Stadium (7-4) | 10-7 | |
| » Starters: Dean Chance vs Milt Pappas | Fourth | 1 out |
| Tuesday, April 30 |
| » Lost to Twins (9-10), 8-1 | Metropolitan Stadium (0-1) | 10-8 | Lost 2 |
| » Starters: Steve Barber vs Camilo Pascual | Fourth | 1½ out |
| Wednesday, May 1 |
| » Lost to White Sox (8-7), 7-0 | Comiskey Park I (0-1) | 10-9 | Lost 3 |
| » Starters: Mike McCormick vs Ray Herbert | Sixth | 3 out |
| » Lost to White Sox (9-7), 6-4 | Comiskey Park I (0-2) | 10-10 | Lost 4 |
| » Starters: Robin Roberts vs Joe Horlen | Sixth | 3 out |
| Thursday, May 2 |
| » Defeated White Sox (9-8), 8-7 | Comiskey Park I (1-2) | 11-10 | |
| » Starters: Dave McNally vs Juan Pizarro | Fifth | 2½ out |
| Friday, May 3 |
| » Defeated Tigers (8-13), 8-5 | Tiger Stadium (1-0) | 12-10 | Won 2 |
| » Starters: Chuck Estrada vs Don Mossi | Third | 2 out |
| Saturday, May 4 |
| » Defeated Tigers (8-14), 8-4 | Tiger Stadium (2-0) | 13-10 | Won 3 |
| » Starters: Steve Barber vs Jim Bunning | Third | 2 out |
| Sunday, May 5 |
| » Lost to Tigers (9-14), 12-4 | Tiger Stadium (2-1) | 13-11 | |
| » Starters: Dick Hall vs Phil Regan | Third | 2 out |
| Tuesday, May 7 |
| » Lost to Red Sox (12-8), 5-1 | Memorial Stadium (7-5) | 13-12 | Lost 2 |
| » Starters: Earl Wilson vs Robin Roberts | Sixth | 2½ out |
| Wednesday, May 8 |
| » Defeated Red Sox (12-9), 10-4 | Memorial Stadium (8-5) | 14-12 | |
| » Starters: Gene Conley vs Steve Barber | Fifth | 1 out |
| Thursday, May 9 |
| » Defeated Red Sox (12-10), 4-1 | Memorial Stadium (9-5) | 15-12 | Won 2 |
| » Starters: Bill Monbouquette vs Chuck Estrada | Second | 1 out |
| Friday, May 10 |
| » Defeated Yankees (12-12), 6-3 | Memorial Stadium (10-5) | 16-12 | Won 3 |
| » Starters: Whitey Ford vs Mike McCormick | Second | 1 out |
| Saturday, May 11 |
| » Lost to Yankees (13-12), 13-1 | Memorial Stadium (10-6) | 16-13 | |
| » Starters: Stan Williams vs Dave McNally | Third | 2 out |
| Sunday, May 12 |
| » Lost to Yankees (14-12), 2-0 | Memorial Stadium (10-7) | 16-14 | Lost 2 |
| » Starters: Jim Bouton vs Steve Barber | Fifth | 2½ out |
| Tuesday, May 14 |
| » Defeated Senators (13-20), 6-1 | Robert F. Kennedy Stadium (2-0) | 17-14 | |
| » Starters: Robin Roberts vs Dave Stenhouse | Fifth | 2 out |
| Wednesday, May 15 |
| » Defeated Senators (13-21), 7-1 | Robert F. Kennedy Stadium (3-0) | 18-14 | Won 2 |
| » Starters: Milt Pappas vs Tom Cheney | Fourth | 2 out |
| Thursday, May 16 |
| » Defeated Senators (13-22), 9-1 | Memorial Stadium (11-7) | 19-14 | Won 3 |
| » Starters: Don Rudolph vs Chuck Estrada | Third | 2 out |
| Saturday, May 18 |
| » Defeated White Sox (20-14), 2-1 | Memorial Stadium (12-7) | 20-14 | Won 4 |
| » Starters: Gary Peters vs Steve Barber | Second | 2 out |
| Sunday, May 19 |
| » Defeated White Sox (20-15), 4-3 | Memorial Stadium (13-7) | 21-14 | Won 5 |
| » Starters: Juan Pizarro vs Robin Roberts | Second | 2 out |
| » Lost to White Sox (21-15), 4-3 | Memorial Stadium (13-8) | 21-15 | |
| » Starters: Ray Herbert vs Mike McCormick | Second | 2 out |
| Monday, May 20 |
| » Defeated Tigers (14-21), 6-0 | Memorial Stadium (14-8) | 22-15 | |
| » Starters: Phil Regan vs Milt Pappas | First | -- |
| Future Oriole David Wells is born in Torrance, CA. |
| Tuesday, May 21 |
| » Defeated Tigers (14-22), 4-2 | Memorial Stadium (15-8) | 23-15 | Won 2 |
| » Starters: Mickey Lolich vs Chuck Estrada | First | -- |
| Wednesday, May 22 |
| » Defeated Tigers (14-23), 2-1 | Memorial Stadium (16-8) | 24-15 | Won 3 |
| » Starters: Jim Bunning vs Steve Barber | First | -- |
| Thursday, May 23 |
| » Defeated Senators (14-28), 6-0 | Memorial Stadium (17-8) | 25-15 | Won 4 |
| » Starters: Claude Osteen vs Robin Roberts | First | -- |
| Friday, May 24 |
| » Defeated Indians (16-18), 7-4 | Cleveland Stadium (1-0) | 26-15 | Won 5 |
| » Starters: Mike McCormick vs Sam McDowell | First | -- |
| Saturday, May 25 |
| » Defeated Indians (16-19), 6-4 | Cleveland Stadium (2-0) | 27-15 | Won 6 |
| » Starters: Milt Pappas vs Pedro Ramos | First | -- |
| Sunday, May 26 |
| » Defeated Indians (16-20), 10-6 | Cleveland Stadium (3-0) | 28-15 | Won 7 |
| » Starters: Steve Barber vs Dick Donovan | First | -- |
| » Defeated Indians (16-21), 6-1 | Cleveland Stadium (4-0) | 29-15 | Won 8 |
| » Starters: Chuck Estrada vs Mudcat Grant | First | -- |
| Tuesday, May 28 |
| » Defeated Athletics (22-19), 4-2 | Municipal Stadium (1-0) | 30-15 | Won 9 |
| » Starters: Robin Roberts vs Ted Bowsfield | First | -- |
| Wednesday, May 29 |
| » Lost to Athletics (23-19), 5-4 | Municipal Stadium (1-1) | 30-16 | |
| » Starters: Mike McCormick vs Dave Wickersham | First | -- |
| Thursday, May 30 |
| » Lost to Athletics (24-19), 7-2 | Municipal Stadium (1-2) | 30-17 | Lost 2 |
| » Starters: Steve Barber vs Ed Rakow | First | -- |
| Friday, May 31 |
| » Lost to Angels (22-27), 7-4 | Dodger Stadium (0-1) | 30-18 | Lost 3 |
| » Starters: Milt Pappas vs Dan Osinski | First | -- |
| Saturday, June 1 |
| » Lost to Angels (23-27), 7-1 | Dodger Stadium (0-2) | 30-19 | Lost 4 |
| » Starters: Chuck Estrada vs Ken McBride | Second | 4 out |
| Sunday, June 2 |
| » Lost to Angels (24-27), 8-2 | Dodger Stadium (0-3) | 30-20 | Lost 5 |
| » Starters: Robin Roberts vs Dean Chance | Second | 3½ out |
| Tuesday, June 4 |
| » Defeated Yankees (26-18), 3-1 | Memorial Stadium (18-8) | 31-20 | |
| » Starters: Ralph Terry vs Steve Barber | First | -- |
| Wednesday, June 5 |
| » Lost to Yankees (27-18), 4-3 | Memorial Stadium (18-9) | 31-21 | |
| » Starters: Whitey Ford vs Milt Pappas | Second | 3½ out |
| Thursday, June 6 |
| » Defeated Yankees (27-19), 4-2 | Memorial Stadium (19-9) | 32-21 | |
| » Starters: Jim Bouton vs Robin Roberts | First | -- |
| Saturday, June 8 |
| » Lost to Red Sox (24-24), 7-1 | Memorial Stadium (19-10) | 32-22 | |
| » Starters: Bill Monbouquette vs Steve Barber | First | -- |
| Sunday, June 9 |
| » Lost to Red Sox (25-24), 3-2 | Memorial Stadium (19-11) | 32-23 | Lost 2 |
| » Starters: Earl Wilson vs Milt Pappas | Second | ½ out |
| Monday, June 10 |
| » Lost to Indians (24-26), 3-2 | Memorial Stadium (19-12) | 32-24 | Lost 3 |
| » Starters: Barry Latman vs Mike McCormick | Second | 1 out |
| Tuesday, June 11 |
| » Lost to Indians (25-26), 9-5 | Memorial Stadium (19-13) | 32-25 | Lost 4 |
| » Starters: Mudcat Grant vs Robin Roberts | Third | 1 out |
| Wednesday, June 12 |
| » Lost to Yankees (30-22), 3-2 | Yankee Stadium (1-3) | 32-26 | Lost 5 |
| » Starters: Dave McNally vs Ralph Terry | Third | 3 out |
| Thursday, June 13 |
| » Defeated Yankees (30-23), 5-4 | Yankee Stadium (2-3) | 33-26 | |
| » Starters: Steve Barber vs Whitey Ford | Third | 1 out |
| Friday, June 14 |
| » Lost to Red Sox (29-25), 5-1 | Fenway Park (1-2) | 33-27 | |
| » Starters: Milt Pappas vs Earl Wilson | Fourth | 2 out |
| Sunday, June 16 |
| » Lost to Red Sox (30-25), 8-1 | Fenway Park (1-3) | 33-28 | Lost 2 |
| » Starters: Ike Delock vs Bill Monbouquette | Fifth | 3½ out |
| » Lost to Red Sox (31-25), 12-5 | Fenway Park (1-4) | 33-29 | Lost 3 |
| » Starters: Robin Roberts vs Dave Morehead | Fifth | 3½ out |
| Monday, June 17 |
| » Defeated Red Sox (31-26), 7-2 | Fenway Park (2-4) | 34-29 | |
| » Starters: Mike McCormick vs Wilbur Wood | Fifth | 3 out |
| Tuesday, June 18 |
| » Lost to Indians (33-27), 7-3 | Cleveland Stadium (4-1) | 34-30 | |
| » Starters: Dave McNally vs Barry Latman | Sixth | 4 out |
| Wednesday, June 19 |
| » Lost to Indians (34-27), 5-4 | Cleveland Stadium (4-2) | 34-31 | Lost 2 |
| » Starters: Steve Barber vs Pedro Ramos | Fifth | 4½ out |
| » Defeated Indians (34-28), 6-2 | Cleveland Stadium (5-2) | 35-31 | |
| » Starters: Milt Pappas vs Gary Bell | Fifth | 4½ out |
| Thursday, June 20 |
| » Lost to Indians (35-28), 11-8 | Cleveland Stadium (5-3) | 35-32 | |
| » Starters: Dick Hall vs Dick Donovan | Sixth | 5½ out |
| Friday, June 21 |
| » Lost to Twins (35-30), 5-2 | Metropolitan Stadium (0-2) | 35-33 | Lost 2 |
| » Starters: Ike Delock vs Lee Stange | Sixth | 5 out |
| » Defeated Twins (35-31), 10-2 | Metropolitan Stadium (1-2) | 36-33 | |
| » Starters: Robin Roberts vs Garry Roggenburk | Sixth | 5 out |
| Saturday, June 22 |
| » Lost to Twins (36-31), 3-1 | Metropolitan Stadium (1-3) | 36-34 | |
| » Starters: Mike McCormick vs Jim Perry | Sixth | 6½ out |
| Sunday, June 23 |
| » Defeated Twins (36-32), 4-1 | Metropolitan Stadium (2-3) | 37-34 | |
| » Starters: Steve Barber vs Dick Stigman | Sixth | 6½ out |
| Monday, June 24 |
| » Lost to Twins (37-32), 6-4 | Metropolitan Stadium (2-4) | 37-35 | |
| » Starters: Milt Pappas vs Jim Kaat | Sixth | 6½ out |
| Tuesday, June 25 |
| » Defeated Angels (37-37), 10-0 | Dodger Stadium (1-3) | 38-35 | |
| » Starters: Robin Roberts vs Dean Chance | Fifth | 5½ out |
| Wednesday, June 26 |
| » Lost to Angels (38-37), 3-1 | Dodger Stadium (1-4) | 38-36 | |
| » Starters: Ike Delock vs Paul Foytack | Sixth | 7 out |
| » Lost to Angels (39-37), 3-2 | Dodger Stadium (1-5) | 38-37 | Lost 2 |
| » Starters: Mike McCormick vs Ken McBride | Sixth | 7 out |
| Thursday, June 27 |
| Future Oriole Nelson Simmons is born in Washington, DC. |
| Friday, June 28 |
| » Defeated Athletics (33-38), 2-1 | Memorial Stadium (20-13) | 39-37 | |
| » Starters: Orlando Pena vs Steve Barber | Seventh | 5½ out |
| Saturday, June 29 |
| » Defeated Athletics (33-39), 3-2 | Memorial Stadium (21-13) | 40-37 | Won 2 |
| » Starters: Moe Drabowsky vs Milt Pappas | Seventh | 5½ out |
| Sunday, June 30 |
| » Lost to Athletics (34-39), 3-1 | Memorial Stadium (21-14) | 40-38 | |
| » Starters: Ed Rakow vs Robin Roberts | Sixth | 6½ out |
| » Defeated Athletics (34-40), 4-3 | Memorial Stadium (22-14) | 41-38 | |
| » Starters: Diego Segui vs Mike McCormick | Sixth | 6½ out |
| Monday, July 1 |
| » Lost to Athletics (35-40), 6-4 | Memorial Stadium (22-15) | 41-39 | |
| » Starters: Dave Wickersham vs Dave McNally | Sixth | 7½ out |
| Tuesday, July 2 |
| » Defeated Angels (41-40), 4-3 | Memorial Stadium (23-15) | 42-39 | |
| » Starters: Paul Foytack vs Steve Barber | Fifth | 7½ out |
| Wednesday, July 3 |
| » Defeated Angels (41-41), 3-1 | Memorial Stadium (24-15) | 43-39 | Won 2 |
| » Starters: Dean Chance vs Milt Pappas | Fifth | 7½ out |
| Thursday, July 4 |
| » Defeated Angels (41-42), 7-4 | Memorial Stadium (25-15) | 44-39 | Won 3 |
| » Starters: Bob Turley vs Mike McCormick | Fifth | 7 out |
| Friday, July 5 |
| » Defeated Twins (44-36), 4-3 | Memorial Stadium (26-15) | 45-39 | Won 4 |
| » Starters: Ray Moore vs Ike Delock | Sixth | 6½ out |
| » Lost to Twins (45-36), 7-5 | Memorial Stadium (26-16) | 45-40 | |
| » Starters: Bill Pleis vs Robin Roberts | Sixth | 6½ out |
| Saturday, July 6 |
| » Defeated Twins (45-37), 2-1 | Memorial Stadium (27-16) | 46-40 | |
| » Starters: Dick Stigman vs Dave McNally | Fifth | 6½ out |
| Sunday, July 7 |
| » Defeated Twins (45-38), 4-3 | Memorial Stadium (28-16) | 47-40 | Won 2 |
| » Starters: Jim Perry vs Milt Pappas | Fifth | 6 out |
| Wednesday, July 10 |
| » Major-league debuts: Jimmy Wynn (Astros) |
| Thursday, July 11 |
| » Defeated Senators (30-57), 7-4 | Robert F. Kennedy Stadium (4-0) | 48-40 | Won 3 |
| » Starters: Robin Roberts vs Tom Cheney | Fourth | 6 out |
| Friday, July 12 |
| » Defeated Senators (30-58), 4-3 | Robert F. Kennedy Stadium (5-0) | 49-40 | Won 4 |
| » Starters: Milt Pappas vs Bennie Daniels | Fourth | 6 out |
| Saturday, July 13 |
| » Lost to Senators (31-58), 4-3 | Robert F. Kennedy Stadium (5-1) | 49-41 | |
| » Starters: Ike Delock vs Jim Duckworth | Fourth | 6 out |
| Sunday, July 14 |
| » Defeated White Sox (48-40), 6-3 | Comiskey Park I (2-2) | 50-41 | |
| » Starters: Mike McCormick vs Ray Herbert | Fourth | 7 out |
| » Lost to White Sox (49-40), 3-2 | Comiskey Park I (2-3) | 50-42 | |
| » Starters: Dave McNally vs John Buzhardt | Fourth | 7 out |
| Monday, July 15 |
| » Lost to White Sox (50-40), 4-0 | Comiskey Park I (2-4) | 50-43 | Lost 2 |
| » Starters: Robin Roberts vs Gary Peters | Fifth | 7 out |
| Tuesday, July 16 |
| » Defeated Tigers (36-50), 5-2 | Tiger Stadium (3-1) | 51-43 | |
| » Starters: Milt Pappas vs Frank Lary | Fifth | 6½ out |
| Wednesday, July 17 |
| » Lost to Tigers (37-50), 9-1 | Tiger Stadium (3-2) | 51-44 | |
| » Starters: Steve Barber vs Hank Aguirre | Fifth | 7½ out |
| Thursday, July 18 |
| » Defeated Tigers (37-51), 8-6 | Tiger Stadium (4-2) | 52-44 | |
| » Starters: Mike McCormick vs Phil Regan | Fifth | 6½ out |
| Friday, July 19 |
| » Lost to Athletics (41-51), 2-1 | Municipal Stadium (1-3) | 52-45 | |
| » Starters: Dave McNally vs Orlando Pena | Fifth | 7 out |
| Saturday, July 20 |
| » Defeated Athletics (41-52), 6-3 | Municipal Stadium (2-3) | 53-45 | |
| » Starters: Robin Roberts vs Dave Wickersham | Fifth | 7 out |
| Sunday, July 21 |
| » Lost to Athletics (42-52), 3-2 | Municipal Stadium (2-4) | 53-46 | |
| » Starters: Milt Pappas vs Moe Drabowsky | Fifth | 8½ out |
| Tuesday, July 23 |
| » Defeated Senators (34-62), 4-0 | Memorial Stadium (29-16) | 54-46 | |
| » Starters: Claude Osteen vs Steve Barber | Fourth | 9 out |
| Wednesday, July 24 |
| » Defeated Senators (34-63), 8-5 | Memorial Stadium (30-16) | 55-46 | Won 2 |
| » Starters: Bennie Daniels vs Dave McNally | Fourth | 9 out |
| Thursday, July 25 |
| » Defeated Senators (34-64), 4-2 | Memorial Stadium (31-16) | 56-46 | Won 3 |
| » Starters: Tom Cheney vs Robin Roberts | Third | 8 out |
| Friday, July 26 |
| » Defeated White Sox (54-45), 6-0 | Memorial Stadium (32-16) | 57-46 | Won 4 |
| » Starters: Dave DeBusschere vs Milt Pappas | Second | 8 out |
| Saturday, July 27 |
| » Lost to White Sox (55-45), 5-3 | Memorial Stadium (32-17) | 57-47 | |
| » Starters: Ray Herbert vs Steve Barber | Third | 9½ out |
| » Lost to White Sox (56-45), 10-1 | Memorial Stadium (32-18) | 57-48 | Lost 2 |
| » Starters: Juan Pizarro vs Mike McCormick | Third | 9½ out |
| Sunday, July 28 |
| » Lost to White Sox (57-45), 4-1 | Memorial Stadium (32-19) | 57-49 | Lost 3 |
| » Starters: Gary Peters vs Dave McNally | Third | 10 out |
| Monday, July 29 |
| » Defeated Tigers (43-57), 2-1 | Memorial Stadium (33-19) | 58-49 | |
| » Starters: Mickey Lolich vs Robin Roberts | Third | 9 out |
| Tuesday, July 30 |
| » Defeated Tigers (43-58), 9-0 | Memorial Stadium (34-19) | 59-49 | Won 2 |
| » Starters: Hank Aguirre vs Milt Pappas | Third | 9 out |
| Wednesday, July 31 |
| » Defeated Tigers (43-59), 2-1 | Memorial Stadium (35-19) | 60-49 | Won 3 |
| » Starters: Frank Lary vs Steve Barber | Third | 9 out |
| Friday, August 2 |
| » Defeated Yankees (66-38), 5-3 | Yankee Stadium (3-3) | 61-49 | Won 4 |
| » Starters: Robin Roberts vs Whitey Ford | Third | 8 out |
| Saturday, August 3 |
| » Lost to Yankees (67-38), 3-2 | Yankee Stadium (3-4) | 61-50 | |
| » Starters: Milt Pappas vs Al Downing | Third | 9 out |
| Sunday, August 4 |
| » Defeated Yankees (67-39), 7-2 | Yankee Stadium (4-4) | 62-50 | |
| » Starters: Steve Barber vs Ralph Terry | Third | 9 out |
| » Lost to Yankees (68-39), 11-10 | Yankee Stadium (4-5) | 62-51 | |
| » Starters: Dave McNally vs Jim Bouton | Third | 9 out |
| Tuesday, August 6 |
| » Defeated Indians (54-59), 6-4 | Memorial Stadium (36-19) | 63-51 | |
| » Starters: Barry Latman vs Robin Roberts | Third | 8½ out |
| Wednesday, August 7 |
| » Lost to Indians (55-59), 4-1 | Memorial Stadium (36-20) | 63-52 | |
| » Starters: Mudcat Grant vs Milt Pappas | Fourth | 9½ out |
| Thursday, August 8 |
| » Lost to Indians (56-59), 2-0 | Memorial Stadium (36-21) | 63-53 | Lost 2 |
| » Starters: Dick Donovan vs Steve Barber | Fourth | 10½ out |
| Friday, August 9 |
| » Defeated Senators (41-73), 7-1 | Robert F. Kennedy Stadium (6-1) | 64-53 | |
| » Starters: Dave McNally vs Jim Duckworth | Fourth | 10½ out |
| Saturday, August 10 |
| » Lost to Senators (42-73), 6-5 | Robert F. Kennedy Stadium (6-2) | 64-54 | |
| » Starters: Robin Roberts vs Bennie Daniels | Fourth | 11½ out |
| Sunday, August 11 |
| » Defeated Senators (42-74), 6-2 | Robert F. Kennedy Stadium (7-2) | 65-54 | |
| » Starters: Milt Pappas vs Tom Cheney | Fourth | 11½ out |
| Tuesday, August 13 |
| » Defeated Twins (65-52), 6-1 | Metropolitan Stadium (3-4) | 66-54 | Won 2 |
| » Starters: Steve Barber vs Dick Stigman | Fourth | 11 out |
| Future Oriole Jeff Ballard is born in Billings, MT. |
| Wednesday, August 14 |
| » Lost to Twins (66-52), 2-1 | Metropolitan Stadium (3-5) | 66-55 | |
| » Starters: Robin Roberts vs Jim Perry | Fourth | 10½ out |
| Thursday, August 15 |
| » Lost to Twins (67-52), 13-3 | Metropolitan Stadium (3-6) | 66-56 | Lost 2 |
| » Starters: Milt Pappas vs Lee Stange | Fourth | 11½ out |
| Friday, August 16 |
| » Defeated Athletics (53-65), 4-3 | Municipal Stadium (3-4) | 67-56 | |
| » Starters: Dave McNally vs Orlando Pena | Fourth | 11½ out |
| Saturday, August 17 |
| » Defeated Athletics (53-66), 6-1 | Municipal Stadium (4-4) | 68-56 | Won 2 |
| » Starters: Steve Barber vs Ed Rakow | Fourth | 10½ out |
| Sunday, August 18 |
| » Lost to Athletics (54-66), 5-4 | Municipal Stadium (4-5) | 68-57 | |
| » Starters: Robin Roberts vs Dave Wickersham | Third | 12 out |
| Wednesday, August 21 |
| » Defeated Angels (57-70), 7-4 | Memorial Stadium (37-21) | 69-57 | |
| » Starters: Don Lee vs Steve Barber | Fourth | 12½ out |
| » Lost to Angels (58-70), 3-2 | Memorial Stadium (37-22) | 69-58 | |
| » Starters: Dan Osinski vs Mike McCormick | Fourth | 12½ out |
| Thursday, August 22 |
| » Defeated Angels (58-71), 5-1 | Memorial Stadium (38-22) | 70-58 | |
| » Starters: Dean Chance vs Dave McNally | Fourth | 11½ out |
| Friday, August 23 |
| » Defeated Twins (69-56), 14-4 | Memorial Stadium (39-22) | 71-58 | Won 2 |
| » Starters: Dick Stigman vs Milt Pappas | Third | 11 out |
| » Defeated Twins (69-57), 6-2 | Memorial Stadium (40-22) | 72-58 | Won 3 |
| » Starters: Jim Perry vs Robin Roberts | Third | 11 out |
| Saturday, August 24 |
| » Lost to Twins (70-57), 1-0 | Memorial Stadium (40-23) | 72-59 | |
| » Starters: Lee Stange vs Dick Hall | Third | 12 out |
| Sunday, August 25 |
| » Lost to Twins (71-57), 5-3 | Memorial Stadium (40-24) | 72-60 | Lost 2 |
| » Starters: Camilo Pascual vs Steve Barber | Fourth | 12½ out |
| Monday, August 26 |
| » Major-league debuts: Dwight Siebler (Twins) |
| Tuesday, August 27 |
| » Lost to Athletics (58-72), 2-1 | Memorial Stadium (40-25) | 72-61 | Lost 3 |
| » Starters: Ed Rakow vs Robin Roberts | Third | 14 out |
| Wednesday, August 28 |
| » Defeated Athletics (58-73), 3-1 | Memorial Stadium (41-25) | 73-61 | |
| » Starters: Dave Wickersham vs Milt Pappas | Fourth | 14 out |
| Friday, August 30 |
| » Lost to Yankees (87-47), 4-1 | Memorial Stadium (41-26) | 73-62 | |
| » Starters: Al Downing vs Steve Barber | Fourth | 14½ out |
| Saturday, August 31 |
| » Lost to Yankees (88-47), 5-3 | Memorial Stadium (41-27) | 73-63 | Lost 2 |
| » Starters: Jim Bouton vs Robin Roberts | Fourth | 15½ out |
| Sunday, September 1 |
| » Lost to Yankees (89-47), 5-4 | Memorial Stadium (41-28) | 73-64 | Lost 3 |
| » Starters: Ralph Terry vs Mike McCormick | Fourth | 16½ out |
| Monday, September 2 |
| » Lost to Red Sox (66-71), 4-3 | Fenway Park (2-5) | 73-65 | Lost 4 |
| » Starters: Milt Pappas vs Bill Monbouquette | Fourth | 17½ out |
| » Lost to Red Sox (67-71), 2-0 | Fenway Park (2-6) | 73-66 | Lost 5 |
| » Starters: Dave McNally vs Bob Heffner | Fourth | 17½ out |
| Tuesday, September 3 |
| » Defeated Red Sox (67-72), 4-3 | Fenway Park (3-6) | 74-66 | |
| » Starters: Steve Barber vs Dave Morehead | Fourth | 16½ out |
| Wednesday, September 4 |
| » Defeated Indians (68-75), 6-5 | Cleveland Stadium (6-3) | 75-66 | Won 2 |
| » Starters: Robin Roberts vs Mudcat Grant | Fourth | 16½ out |
| » Major-league debuts: Bob Chance (Indians) |
| Friday, September 6 |
| » Defeated Red Sox (67-75), 6-4 | Memorial Stadium (42-28) | 76-66 | Won 3 |
| » Starters: Bill Monbouquette vs Milt Pappas | Fourth | 16½ out |
| » Defeated Red Sox (67-76), 4-2 | Memorial Stadium (43-28) | 77-66 | Won 4 |
| » Starters: Bob Heffner vs Mike McCormick | Fourth | 16½ out |
| Saturday, September 7 |
| » Lost to Red Sox (68-76), 4-1 | Memorial Stadium (43-29) | 77-67 | |
| » Starters: Dave Morehead vs Dave McNally | Fourth | 17½ out |
| » Major-league debuts: Sam Bowens (Orioles) |
| Sunday, September 8 |
| » Lost to Red Sox (69-76), 6-3 | Memorial Stadium (43-30) | 77-68 | Lost 2 |
| » Starters: Gene Conley vs Steve Barber | Fourth | 18½ out |
| Monday, September 9 |
| » Lost to White Sox (82-64), 9-4 | Comiskey Park I (2-5) | 77-69 | Lost 3 |
| » Starters: Robin Roberts vs Gary Peters | Fourth | 18½ out |
| Tuesday, September 10 |
| » Defeated White Sox (82-65), 2-1 | Comiskey Park I (3-5) | 78-69 | |
| » Starters: Milt Pappas vs Frank Baumann | Fourth | 17½ out |
| Wednesday, September 11 |
| » Lost to White Sox (83-65), 3-2 | Comiskey Park I (3-6) | 78-70 | |
| » Starters: Mike McCormick vs Eddie Fisher | Fourth | 18½ out |
| Thursday, September 12 |
| Future Oriole Keith Hughes is born in Bryn Mawr, PA. |
| Friday, September 13 |
| » Lost to Tigers (73-75), 3-2 | Tiger Stadium (4-3) | 78-71 | Lost 2 |
| » Starters: Steve Barber vs Phil Regan | Third | 20 out |
| Saturday, September 14 |
| » Lost to Tigers (74-75), 3-2 | Tiger Stadium (4-4) | 78-72 | Lost 3 |
| » Starters: Robin Roberts vs Jim Bunning | Fourth | 20½ out |
| Sunday, September 15 |
| » Defeated Tigers (74-76), 2-1 | Tiger Stadium (5-4) | 79-72 | |
| » Starters: Milt Pappas vs Frank Lary | Fourth | 20½ out |
| Wednesday, September 18 |
| » Defeated Angels (68-85), 3-1 | Dodger Stadium (2-5) | 80-72 | Won 2 |
| » Starters: Steve Barber vs Aubrey Gatewood | Fourth | 19 out |
| » Defeated Angels (68-86), 7-5 | Dodger Stadium (3-5) | 81-72 | Won 3 |
| » Starters: Mike McCormick vs Ken McBride | Fourth | 19 out |
| Thursday, September 19 |
| » Lost to Angels (69-86), 7-2 | Dodger Stadium (3-6) | 81-73 | |
| » Starters: Dave McNally vs Bo Belinsky | Fourth | 19½ out |
| Friday, September 20 |
| » Defeated Senators (53-100), 7-6 | Memorial Stadium (44-30) | 82-73 | |
| » Starters: Carl Bouldin vs Milt Pappas | Fourth | 19 out |
| Sunday, September 22 |
| » Defeated Senators (53-101), 6-3 | Memorial Stadium (45-30) | 83-73 | Won 2 |
| » Starters: Jack Jenkins vs Robin Roberts | Fourth | 19 out |
| » Lost to Senators (54-101), 4-2 | Memorial Stadium (45-31) | 83-74 | |
| » Starters: Jim Hannan vs John Miller | Fourth | 19 out |
| Tuesday, September 24 |
| » Lost to White Sox (91-66), 15-0 | Memorial Stadium (45-32) | 83-75 | Lost 2 |
| » Starters: Ray Herbert vs Steve Barber | Fourth | 20 out |
| Wednesday, September 25 |
| » Defeated White Sox (91-67), 10-2 | Memorial Stadium (46-32) | 84-75 | |
| » Starters: Gary Peters vs Mike McCormick | Fourth | 20 out |
| Friday, September 27 |
| » Defeated Tigers (78-82), 5-2 | Memorial Stadium (47-32) | 85-75 | Won 2 |
| » Starters: Hank Aguirre vs Wally Bunker | Fourth | 19 out |
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