| Tuesday, January 22 |
| Future Indian Jeff Treadway is born in Columbus, GA. |
| Wednesday, February 20 |
| Former Indian Bill Hinchman dies in Columbus, OH at the age of 80. |
| Friday, March 1 |
| Future Indian Rich Rodriguez is born in Downey, CA. |
| Thursday, March 14 |
| Former Indian Charlie Harris dies in Gainesville, FL at the age of 86. |
| Thursday, March 21 |
| Future Indian Shawon Dunston is born in Brooklyn, NY. |
| Tuesday, March 26 |
| Future Indian Luis Medina is born in Santa Monica, CA. |
| Monday, April 8 |
| » Major-league debuts: Tom Brown (Senators) |
| Tuesday, April 9 |
| » Defeated Twins (0-1), 5-4 | Metropolitan Stadium (1-0) | 1-0 | |
| » Starters: Mudcat Grant vs Camilo Pascual | First | -- |
| » Major-league debuts: Jimmie Hall (Twins) Vic Davalillo (Indians) |
| Wednesday, April 10 |
| » Lost to Twins (1-1), 5-3 | Metropolitan Stadium (1-1) | 1-1 | |
| » Starters: Sam McDowell vs Jim Kaat | Second | 1 out |
| Thursday, April 11 |
| » Lost to Tigers (2-1), 6-1 | Cleveland Stadium (0-1) | 1-2 | Lost 2 |
| » Starters: Don Mossi vs Dick Donovan | Fourth | 2 out |
| Friday, April 12 |
| » Major-league debuts: Fred Lasher (Twins) |
| Saturday, April 13 |
| » Lost to Tigers (3-1), 4-1 | Cleveland Stadium (0-2) | 1-3 | Lost 3 |
| » Starters: Phil Regan vs Pedro Ramos | Third | 2 out |
| Sunday, April 14 |
| » Defeated Tigers (3-2), 6-0 | Cleveland Stadium (1-2) | 2-3 | |
| » Starters: Jim Bunning vs Mudcat Grant | Fourth | 2 out |
| Tuesday, April 16 |
| » Defeated Senators (2-4), 3-0 | Cleveland Stadium (2-2) | 3-3 | Won 2 |
| » Starters: Claude Osteen vs Sam McDowell | Second | 1 out |
| Friday, April 19 |
| » Lost to Orioles (5-3), 8-5 | Memorial Stadium (0-1) | 3-4 | |
| » Starters: Pedro Ramos vs Milt Pappas | Fifth | 2 out |
| Saturday, April 20 |
| » Lost to Orioles (6-3), 8-1 | Memorial Stadium (0-2) | 3-5 | Lost 2 |
| » Starters: Mudcat Grant vs Dave McNally | Seventh | 2½ out |
| Sunday, April 21 |
| » Lost to Orioles (7-3), 7-0 | Memorial Stadium (0-3) | 3-6 | Lost 3 |
| » Starters: Sam McDowell vs Steve Barber | Fifth | 2½ out |
| » Defeated Orioles (7-4), 2-0 | Memorial Stadium (1-3) | 4-6 | |
| » Starters: Dick Donovan vs Robin Roberts | Fifth | 2½ out |
| Wednesday, April 24 |
| » Defeated Red Sox (6-6), 2-0 | Cleveland Stadium (3-2) | 5-6 | Won 2 |
| » Starters: Earl Wilson vs Gary Bell | Seventh | 2½ out |
| Saturday, April 27 |
| » Lost to Yankees (7-5), 8-1 | Yankee Stadium (0-1) | 5-7 | |
| » Starters: Dick Donovan vs Ralph Terry | Sixth | 3 out |
| Sunday, April 28 |
| » Lost to Yankees (8-5), 5-0 | Yankee Stadium (0-2) | 5-8 | Lost 2 |
| » Starters: Mudcat Grant vs Whitey Ford | Eighth | 4 out |
| Wednesday, May 1 |
| » Lost to Athletics (13-7), 11-3 | Municipal Stadium (0-1) | 5-9 | Lost 3 |
| » Starters: Gary Bell vs Orlando Pena | Ninth | 5 out |
| Thursday, May 2 |
| » Defeated Athletics (13-8), 15-6 | Municipal Stadium (1-1) | 6-9 | |
| » Starters: Pedro Ramos vs Dave Wickersham | Eighth | 3½ out |
| Friday, May 3 |
| » Defeated Angels (12-12), 2-1 | Dodger Stadium (1-0) | 7-9 | Won 2 |
| » Starters: Sam McDowell vs Don Lee | Sixth | 4 out |
| Saturday, May 4 |
| » Defeated Angels (12-13), 6-0 | Dodger Stadium (2-0) | 8-9 | Won 3 |
| » Starters: Mudcat Grant vs Ken McBride | Seventh | 4 out |
| Former Indian Pat McNulty dies in Hollywood, CA at the age of 65. |
| Sunday, May 5 |
| » Defeated Angels (12-14), 4-3 | Dodger Stadium (3-0) | 9-9 | Won 4 |
| » Starters: Dick Donovan vs Bo Belinsky | Fifth | 3 out |
| Tuesday, May 7 |
| » Defeated Senators (10-16), 7-3 | Robert F. Kennedy Stadium (1-0) | 10-9 | Won 5 |
| » Starters: Sam McDowell vs Claude Osteen | Fifth | 1½ out |
| Wednesday, May 8 |
| » Lost to Senators (11-16), 6-3 | Robert F. Kennedy Stadium (1-1) | 10-10 | |
| » Starters: Jack Kralick vs Don Rudolph | Seventh | 2 out |
| Thursday, May 9 |
| » Lost to Senators (12-16), 6-0 | Robert F. Kennedy Stadium (1-2) | 10-11 | Lost 2 |
| » Starters: Mudcat Grant vs Dave Stenhouse | Sixth | 3 out |
| Friday, May 10 |
| » Lost to Tigers (12-15), 14-0 | Tiger Stadium (0-1) | 10-12 | Lost 3 |
| » Starters: Gary Bell vs Phil Regan | Seventh | 4 out |
| Saturday, May 11 |
| » Defeated Tigers (12-16), 6-5 | Tiger Stadium (1-1) | 11-12 | |
| » Starters: Dick Donovan vs Hank Aguirre | Sixth | 4 out |
| » Major-league debuts: Don Wert (Tigers) |
| Sunday, May 12 |
| » Defeated Tigers (12-17), 9-3 | Tiger Stadium (2-1) | 12-12 | Won 2 |
| » Starters: Sam McDowell vs Don Mossi | Sixth | 3½ out |
| » Major-league debuts: Mickey Lolich (Tigers) |
| Tuesday, May 14 |
| » Lost to Athletics (18-13), 5-2 | Cleveland Stadium (3-3) | 12-13 | |
| » Starters: Ed Rakow vs Jack Kralick | Seventh | 4 out |
| Wednesday, May 15 |
| » Defeated Athletics (18-14), 1-0 | Cleveland Stadium (4-3) | 13-13 | |
| » Starters: Orlando Pena vs Mudcat Grant | Fifth | 4 out |
| Thursday, May 16 |
| » Defeated White Sox (20-13), 5-4 | Cleveland Stadium (5-3) | 14-13 | Won 2 |
| » Starters: John Buzhardt vs Dick Donovan | Sixth | 3 out |
| Friday, May 17 |
| » Lost to Twins (12-20), 11-4 | Cleveland Stadium (5-4) | 14-14 | |
| » Starters: Jim Perry vs Gary Bell | Fifth | 3½ out |
| Saturday, May 18 |
| » Lost to Twins (13-20), 8-1 | Cleveland Stadium (5-5) | 14-15 | Lost 2 |
| » Starters: Jim Kaat vs Sam McDowell | Fifth | 3½ out |
| Sunday, May 19 |
| » Defeated Twins (13-21), 6-4 | Cleveland Stadium (6-5) | 15-15 | |
| » Starters: Dick Stigman vs Pedro Ramos | Fifth | 3½ out |
| » Lost to Twins (14-21), 7-6 | Cleveland Stadium (6-6) | 15-16 | |
| » Starters: Jim Roland vs Mudcat Grant | Fifth | 3½ out |
| Monday, May 20 |
| » Defeated Angels (18-23), 7-5 | Cleveland Stadium (7-6) | 16-16 | |
| » Starters: Don Lee vs Jack Kralick | Fifth | 3½ out |
| Tuesday, May 21 |
| Future Indian Jose Roman is born in Santo Domingo, D.R. |
| Wednesday, May 22 |
| » Lost to Angels (19-23), 7-6 | Cleveland Stadium (7-7) | 16-17 | |
| » Starters: Dan Osinski vs Dick Donovan | Fifth | 5 out |
| Friday, May 24 |
| » Lost to Orioles (26-15), 7-4 | Cleveland Stadium (7-8) | 16-18 | Lost 2 |
| » Starters: Mike McCormick vs Sam McDowell | Sixth | 6½ out |
| Saturday, May 25 |
| » Lost to Orioles (27-15), 6-4 | Cleveland Stadium (7-9) | 16-19 | Lost 3 |
| » Starters: Milt Pappas vs Pedro Ramos | Seventh | 7½ out |
| Sunday, May 26 |
| » Lost to Orioles (28-15), 10-6 | Cleveland Stadium (7-10) | 16-20 | Lost 4 |
| » Starters: Steve Barber vs Dick Donovan | Eighth | 9½ out |
| » Lost to Orioles (29-15), 6-1 | Cleveland Stadium (7-11) | 16-21 | Lost 5 |
| » Starters: Chuck Estrada vs Mudcat Grant | Eighth | 9½ out |
| Tuesday, May 28 |
| » Defeated White Sox (24-19), 3-2 | Comiskey Park I (1-0) | 17-21 | |
| » Starters: Jack Kralick vs Ray Herbert | Seventh | 9½ out |
| Thursday, May 30 |
| » Lost to White Sox (25-19), 8-4 | Comiskey Park I (1-1) | 17-22 | |
| » Starters: Sam McDowell vs Juan Pizarro | Eighth | 9½ out |
| » Lost to White Sox (26-19), 4-2 | Comiskey Park I (1-2) | 17-23 | Lost 2 |
| » Starters: Barry Latman vs Gary Peters | Eighth | 9½ out |
| Friday, May 31 |
| » Lost to Yankees (25-15), 4-0 | Cleveland Stadium (7-12) | 17-24 | Lost 3 |
| » Starters: Whitey Ford vs Mudcat Grant | Ninth | 9½ out |
| Saturday, June 1 |
| » Lost to Yankees (26-15), 5-2 | Cleveland Stadium (7-13) | 17-25 | Lost 4 |
| » Starters: Jim Bouton vs Dick Donovan | Ninth | 9½ out |
| Sunday, June 2 |
| » Defeated Yankees (26-16), 5-0 | Cleveland Stadium (8-13) | 18-25 | |
| » Starters: Bill Stafford vs Jack Kralick | Eighth | 7½ out |
| » Defeated Yankees (26-17), 7-2 | Cleveland Stadium (9-13) | 19-25 | Won 2 |
| » Starters: Stan Williams vs Sam McDowell | Eighth | 7½ out |
| Tuesday, June 4 |
| » Defeated Tigers (20-28), 6-4 | Cleveland Stadium (10-13) | 20-25 | Won 3 |
| » Starters: Mickey Lolich vs Barry Latman | Eighth | 8 out |
| Wednesday, June 5 |
| » Lost to Tigers (21-28), 5-4 | Cleveland Stadium (10-14) | 20-26 | |
| » Starters: Jim Bunning vs Mudcat Grant | Eighth | 7½ out |
| Friday, June 7 |
| » Defeated Senators (19-36), 8-1 | Robert F. Kennedy Stadium (2-2) | 21-26 | |
| » Starters: Dick Donovan vs Jim Duckworth | Eighth | 8 out |
| Saturday, June 8 |
| » Defeated Senators (19-37), 6-1 | Robert F. Kennedy Stadium (3-2) | 22-26 | Won 2 |
| » Starters: Jack Kralick vs Bennie Daniels | Seventh | 7 out |
| Sunday, June 9 |
| » Defeated Senators (19-38), 7-3 | Robert F. Kennedy Stadium (4-2) | 23-26 | Won 3 |
| » Starters: Sam McDowell vs Tom Cheney | Seventh | 6½ out |
| Monday, June 10 |
| » Defeated Orioles (32-24), 3-2 | Memorial Stadium (2-3) | 24-26 | Won 4 |
| » Starters: Barry Latman vs Mike McCormick | Seventh | 6 out |
| Tuesday, June 11 |
| » Defeated Orioles (32-25), 9-5 | Memorial Stadium (3-3) | 25-26 | Won 5 |
| » Starters: Mudcat Grant vs Robin Roberts | Seventh | 5 out |
| Wednesday, June 12 |
| » Defeated Tigers (24-31), 12-6 | Tiger Stadium (3-1) | 26-26 | Won 6 |
| » Starters: Dick Donovan vs Hank Aguirre | Seventh | 4 out |
| Thursday, June 13 |
| » Defeated Tigers (24-32), 5-3 | Tiger Stadium (4-1) | 27-26 | Won 7 |
| » Starters: Jack Kralick vs Phil Regan | Seventh | 4 out |
| Friday, June 14 |
| » Lost to Senators (21-41), 5-2 | Cleveland Stadium (10-15) | 27-27 | |
| » Starters: Tom Cheney vs Barry Latman | Sixth | 4½ out |
| » Defeated Senators (21-42), 3-2 | Cleveland Stadium (11-15) | 28-27 | |
| » Starters: Claude Osteen vs Gary Bell | Sixth | 4½ out |
| Saturday, June 15 |
| » Defeated Senators (21-43), 4-0 | Cleveland Stadium (12-15) | 29-27 | Won 2 |
| » Starters: Bennie Daniels vs Pedro Ramos | Sixth | 3½ out |
| Sunday, June 16 |
| » Defeated Senators (21-44), 4-2 | Cleveland Stadium (13-15) | 30-27 | Won 3 |
| » Starters: Dave Stenhouse vs Mudcat Grant | Fourth | 3½ out |
| » Defeated Senators (21-45), 6-4 | Cleveland Stadium (14-15) | 31-27 | Won 4 |
| » Starters: Don Rudolph vs Dick Donovan | Fourth | 3½ out |
| Monday, June 17 |
| » Defeated Senators (21-46), 1-0 | Cleveland Stadium (15-15) | 32-27 | Won 5 |
| » Starters: Jim Duckworth vs Jack Kralick | Fourth | 3 out |
| Tuesday, June 18 |
| » Defeated Orioles (34-30), 7-3 | Cleveland Stadium (16-15) | 33-27 | Won 6 |
| » Starters: Dave McNally vs Barry Latman | Fourth | 3 out |
| Wednesday, June 19 |
| » Defeated Orioles (34-31), 5-4 | Cleveland Stadium (17-15) | 34-27 | Won 7 |
| » Starters: Steve Barber vs Pedro Ramos | Fourth | 3½ out |
| » Lost to Orioles (35-31), 6-2 | Cleveland Stadium (17-16) | 34-28 | |
| » Starters: Milt Pappas vs Gary Bell | Fourth | 3½ out |
| Thursday, June 20 |
| » Defeated Orioles (35-32), 11-8 | Cleveland Stadium (18-16) | 35-28 | |
| » Starters: Dick Hall vs Dick Donovan | Fourth | 3½ out |
| Friday, June 21 |
| » Lost to White Sox (39-28), 2-0 | Cleveland Stadium (18-17) | 35-29 | |
| » Starters: Juan Pizarro vs Early Wynn | Fourth | 3½ out |
| Saturday, June 22 |
| » Lost to White Sox (40-28), 2-1 | Cleveland Stadium (18-18) | 35-30 | Lost 2 |
| » Starters: Gary Peters vs Mudcat Grant | Fourth | 5 out |
| Sunday, June 23 |
| » Lost to White Sox (41-28), 2-1 | Cleveland Stadium (18-19) | 35-31 | Lost 3 |
| » Starters: Ray Herbert vs Jack Kralick | Fourth | 5½ out |
| » Defeated White Sox (41-29), 2-0 | Cleveland Stadium (19-19) | 36-31 | |
| » Starters: Dave DeBusschere vs Barry Latman | Fourth | 5½ out |
| Monday, June 24 |
| » Lost to Red Sox (36-29), 7-5 | Fenway Park (0-1) | 36-32 | |
| » Starters: Gary Bell vs Bob Heffner | Fifth | 5½ out |
| Tuesday, June 25 |
| » Lost to Red Sox (37-29), 4-1 | Fenway Park (0-2) | 36-33 | Lost 2 |
| » Starters: Dick Donovan vs Bill Monbouquette | Sixth | 6 out |
| » Lost to Red Sox (38-29), 3-2 | Fenway Park (0-3) | 36-34 | Lost 3 |
| » Starters: Sam McDowell vs Earl Wilson | Sixth | 6 out |
| Wednesday, June 26 |
| » Lost to Red Sox (39-29), 6-5 | Fenway Park (0-4) | 36-35 | Lost 4 |
| » Starters: Mudcat Grant vs Dave Morehead | Seventh | 7 out |
| Thursday, June 27 |
| » Defeated Red Sox (39-30), 6-4 | Fenway Park (1-4) | 37-35 | |
| » Starters: Barry Latman vs Wilbur Wood | Fifth | 6 out |
| Friday, June 28 |
| » Defeated White Sox (44-31), 4-3 | Comiskey Park I (2-2) | 38-35 | Won 2 |
| » Starters: Early Wynn vs Dave DeBusschere | Fifth | 5 out |
| Saturday, June 29 |
| » Defeated White Sox (44-32), 5-2 | Comiskey Park I (3-2) | 39-35 | Won 3 |
| » Starters: Jack Kralick vs John Buzhardt | Fifth | 5 out |
| Sunday, June 30 |
| » Defeated White Sox (44-33), 8-4 | Comiskey Park I (4-2) | 40-35 | Won 4 |
| » Starters: Dick Donovan vs Juan Pizarro | Fifth | 6 out |
| » Lost to White Sox (45-33), 4-0 | Comiskey Park I (4-3) | 40-36 | |
| » Starters: Mudcat Grant vs Gary Peters | Fifth | 6 out |
| Tuesday, July 2 |
| » Lost to Red Sox (41-34), 6-1 | Cleveland Stadium (19-20) | 40-37 | Lost 2 |
| » Starters: Dave Morehead vs Barry Latman | Sixth | 7½ out |
| Wednesday, July 3 |
| » Lost to Red Sox (42-34), 6-2 | Cleveland Stadium (19-21) | 40-38 | Lost 3 |
| » Starters: Bob Heffner vs Pedro Ramos | Sixth | 8½ out |
| Thursday, July 4 |
| » Defeated Red Sox (42-35), 4-3 | Cleveland Stadium (20-21) | 41-38 | |
| » Starters: Bill Monbouquette vs Early Wynn | Sixth | 7½ out |
| » Defeated Red Sox (42-36), 7-5 | Cleveland Stadium (21-21) | 42-38 | Won 2 |
| » Starters: Chet Nichols vs Mudcat Grant | Sixth | 7½ out |
| Friday, July 5 |
| » Defeated Yankees (48-30), 4-1 | Cleveland Stadium (22-21) | 43-38 | Won 3 |
| » Starters: Jim Bouton vs Dick Donovan | Fifth | 6½ out |
| Saturday, July 6 |
| » Lost to Yankees (49-30), 11-6 | Cleveland Stadium (22-22) | 43-39 | |
| » Starters: Al Downing vs Barry Latman | Sixth | 7½ out |
| Sunday, July 7 |
| » Defeated Yankees (49-31), 11-3 | Cleveland Stadium (23-22) | 44-39 | |
| » Starters: Ralph Terry vs Jack Kralick | Sixth | 7½ out |
| » Lost to Yankees (50-31), 7-4 | Cleveland Stadium (23-23) | 44-40 | |
| » Starters: Stan Williams vs Pedro Ramos | Sixth | 7½ out |
| Thursday, July 11 |
| » Defeated Athletics (36-47), 8-6 | Municipal Stadium (2-1) | 45-40 | |
| » Starters: Dick Donovan vs Dave Wickersham | Fifth | 7½ out |
| Saturday, July 13 |
| » Lost to Athletics (37-47), 6-5 | Municipal Stadium (2-2) | 45-41 | |
| » Starters: Jack Kralick vs Diego Segui | Fifth | 7½ out |
| » Defeated Athletics (37-48), 7-4 | Municipal Stadium (3-2) | 46-41 | |
| » Starters: Early Wynn vs Moe Drabowsky | Fifth | 7½ out |
| Sunday, July 14 |
| » Lost to Twins (47-41), 5-3 | Metropolitan Stadium (1-2) | 46-42 | |
| » Starters: Pedro Ramos vs Jim Kaat | Sixth | 9½ out |
| » Lost to Twins (48-41), 8-2 | Metropolitan Stadium (1-3) | 46-43 | Lost 2 |
| » Starters: Barry Latman vs Bill Pleis | Sixth | 9½ out |
| Former Indian Bill Lindsay dies in Greensboro, NC at the age of 83. |
| Monday, July 15 |
| » Lost to Twins (49-41), 13-1 | Metropolitan Stadium (1-4) | 46-44 | Lost 3 |
| » Starters: Dick Donovan vs Dick Stigman | Sixth | 9½ out |
| Tuesday, July 16 |
| » Lost to Angels (44-50), 2-1 | Dodger Stadium (3-1) | 46-45 | Lost 4 |
| » Starters: Mudcat Grant vs Ken McBride | Sixth | 10 out |
| Wednesday, July 17 |
| » Lost to Angels (45-50), 7-2 | Dodger Stadium (3-2) | 46-46 | Lost 5 |
| » Starters: Jerry Walker vs Dean Chance | Sixth | 11½ out |
| » Lost to Angels (46-50), 1-0 | Dodger Stadium (3-3) | 46-47 | Lost 6 |
| » Starters: Jack Kralick vs Paul Foytack | Sixth | 11½ out |
| Friday, July 19 |
| Future Indian Mark Carreon is born in Chicago, IL. |
| Saturday, July 20 |
| » Lost to Yankees (56-34), 5-4 | Yankee Stadium (0-3) | 46-48 | Lost 7 |
| » Starters: Dick Donovan vs Whitey Ford | Sixth | 12 out |
| Sunday, July 21 |
| » Lost to Yankees (57-34), 5-2 | Yankee Stadium (0-4) | 46-49 | Lost 8 |
| » Starters: Jack Kralick vs Al Downing | Sixth | 14 out |
| » Lost to Yankees (58-34), 5-4 | Yankee Stadium (0-5) | 46-50 | Lost 9 |
| » Starters: Barry Latman vs Jim Bouton | Sixth | 14 out |
| Monday, July 22 |
| Future Indian Denny Gonzalez is born in Sabana Grande De Boya, D.R. |
| Tuesday, July 23 |
| » Defeated Twins (52-44), 3-2 | Cleveland Stadium (24-23) | 47-50 | |
| » Starters: Camilo Pascual vs Mudcat Grant | Fifth | 14½ out |
| Wednesday, July 24 |
| » Lost to Twins (53-44), 9-0 | Cleveland Stadium (24-24) | 47-51 | |
| » Starters: Dick Stigman vs Pedro Ramos | Sixth | 16 out |
| » Lost to Twins (54-44), 5-0 | Cleveland Stadium (24-25) | 47-52 | Lost 2 |
| » Starters: Jim Kaat vs Dick Donovan | Sixth | 16 out |
| Thursday, July 25 |
| » Defeated Twins (54-45), 3-2 | Cleveland Stadium (25-25) | 48-52 | |
| » Starters: Jim Perry vs Barry Latman | Sixth | 15 out |
| Friday, July 26 |
| » Defeated Athletics (46-53), 3-2 | Cleveland Stadium (26-25) | 49-52 | Won 2 |
| » Starters: Moe Drabowsky vs Jack Kralick | Sixth | 15 out |
| Saturday, July 27 |
| » Defeated Athletics (46-54), 3-2 | Cleveland Stadium (27-25) | 50-52 | Won 3 |
| » Starters: Diego Segui vs Early Wynn | Sixth | 15 out |
| Sunday, July 28 |
| » Lost to Athletics (47-54), 3-0 | Cleveland Stadium (27-26) | 50-53 | |
| » Starters: Orlando Pena vs Jerry Walker | Sixth | 15 out |
| » Defeated Athletics (47-55), 12-7 | Cleveland Stadium (28-26) | 51-53 | |
| » Starters: Bill Fischer vs Mudcat Grant | Sixth | 15 out |
| Monday, July 29 |
| » Lost to Angels (52-56), 11-0 | Cleveland Stadium (28-27) | 51-54 | |
| » Starters: Dean Chance vs Dick Donovan | Sixth | 15 out |
| Tuesday, July 30 |
| » Lost to Angels (53-56), 6-4 | Cleveland Stadium (28-28) | 51-55 | Lost 2 |
| » Starters: Ken McBride vs Jack Kralick | Seventh | 16 out |
| Wednesday, July 31 |
| » Defeated Angels (53-57), 1-0 | Cleveland Stadium (29-28) | 52-55 | |
| » Starters: Fred Newman vs Barry Latman | Sixth | 15½ out |
| » Defeated Angels (53-58), 9-5 | Cleveland Stadium (30-28) | 53-55 | Won 2 |
| » Starters: Eli Grba vs Pedro Ramos | Sixth | 15½ out |
| Friday, August 2 |
| » Lost to Tigers (44-59), 10-9 | Tiger Stadium (4-2) | 53-56 | |
| » Starters: Mudcat Grant vs Jim Bunning | Sixth | 15½ out |
| Saturday, August 3 |
| » Lost to Tigers (45-59), 7-5 | Tiger Stadium (4-3) | 53-57 | Lost 2 |
| » Starters: Dick Donovan vs Phil Regan | Sixth | 16½ out |
| Sunday, August 4 |
| » Lost to Tigers (46-59), 2-0 | Tiger Stadium (4-4) | 53-58 | Lost 3 |
| » Starters: Jack Kralick vs Hank Aguirre | Sixth | 16½ out |
| » Defeated Tigers (46-60), 3-2 | Tiger Stadium (5-4) | 54-58 | |
| » Starters: Pedro Ramos vs Mickey Lolich | Sixth | 16½ out |
| » Major-league debuts: George Smith (Tigers) |
| Tuesday, August 6 |
| » Lost to Orioles (63-51), 6-4 | Memorial Stadium (3-4) | 54-59 | |
| » Starters: Barry Latman vs Robin Roberts | Sixth | 17 out |
| Wednesday, August 7 |
| » Defeated Orioles (63-52), 4-1 | Memorial Stadium (4-4) | 55-59 | |
| » Starters: Mudcat Grant vs Milt Pappas | Sixth | 17 out |
| Thursday, August 8 |
| » Defeated Orioles (63-53), 2-0 | Memorial Stadium (5-4) | 56-59 | Won 2 |
| » Starters: Dick Donovan vs Steve Barber | Fifth | 17 out |
| Friday, August 9 |
| » Lost to Athletics (51-61), 5-1 | Cleveland Stadium (30-29) | 56-60 | |
| » Starters: Moe Drabowsky vs Jack Kralick | Fifth | 18 out |
| Saturday, August 10 |
| » Lost to Athletics (52-61), 6-3 | Cleveland Stadium (30-30) | 56-61 | Lost 2 |
| » Starters: Diego Segui vs Pedro Ramos | Fifth | 19 out |
| Sunday, August 11 |
| » Defeated Athletics (52-62), 2-1 | Cleveland Stadium (31-30) | 57-61 | |
| » Starters: Orlando Pena vs Barry Latman | Fifth | 19 out |
| Future Indian Mike Huff is born in Honolulu, HI. |
| Tuesday, August 13 |
| » Lost to White Sox (67-50), 3-0 | Comiskey Park I (4-4) | 57-62 | |
| » Starters: Mudcat Grant vs Dave DeBusschere | Fifth | 19½ out |
| Wednesday, August 14 |
| » Defeated White Sox (67-51), 1-0 | Comiskey Park I (5-4) | 58-62 | |
| » Starters: Dick Donovan vs Ray Herbert | Sixth | 18 out |
| Friday, August 16 |
| » Lost to Red Sox (58-61), 7-4 | Fenway Park (1-5) | 58-63 | |
| » Starters: Jack Kralick vs Bob Heffner | Sixth | 19½ out |
| Saturday, August 17 |
| » Lost to Red Sox (59-61), 10-3 | Fenway Park (1-6) | 58-64 | Lost 2 |
| » Starters: Barry Latman vs Bill Monbouquette | Sixth | 19½ out |
| Sunday, August 18 |
| » Defeated Red Sox (59-62), 7-4 | Fenway Park (2-6) | 59-64 | |
| » Starters: Mudcat Grant vs Dave Morehead | Fifth | 20 out |
| Monday, August 19 |
| » Defeated Red Sox (59-63), 8-3 | Fenway Park (3-6) | 60-64 | Won 2 |
| » Starters: Pedro Ramos vs Arnold Earley | Fifth | 19½ out |
| Tuesday, August 20 |
| » Defeated Yankees (78-44), 2-1 | Yankee Stadium (1-5) | 61-64 | Won 3 |
| » Starters: Dick Donovan vs Whitey Ford | Fifth | 18½ out |
| Future Indian Brad Arnsberg is born in Seattle, WA. |
| Wednesday, August 21 |
| » Lost to Yankees (79-44), 3-1 | Yankee Stadium (1-6) | 61-65 | |
| » Starters: Jack Kralick vs Al Downing | Fifth | 20½ out |
| » Lost to Yankees (80-44), 3-1 | Yankee Stadium (1-7) | 61-66 | Lost 2 |
| » Starters: Barry Latman vs Stan Williams | Fifth | 20½ out |
| Thursday, August 22 |
| » Defeated Yankees (80-45), 7-4 | Yankee Stadium (2-7) | 62-66 | |
| » Starters: Mudcat Grant vs Ralph Terry | Fifth | 19½ out |
| Friday, August 23 |
| » Lost to Red Sox (61-65), 3-2 | Cleveland Stadium (31-31) | 62-67 | |
| » Starters: Earl Wilson vs Pedro Ramos | Sixth | 20½ out |
| Saturday, August 24 |
| » Defeated Red Sox (61-66), 6-2 | Cleveland Stadium (32-31) | 63-67 | |
| » Starters: Bob Turley vs Dick Donovan | Fourth | 20½ out |
| Sunday, August 25 |
| » Lost to Red Sox (62-66), 8-3 | Cleveland Stadium (32-32) | 63-68 | |
| » Starters: Bill Monbouquette vs Barry Latman | Fifth | 20½ out |
| » Defeated Red Sox (62-67), 2-1 | Cleveland Stadium (33-32) | 64-68 | |
| » Starters: Bob Heffner vs Jack Kralick | Fifth | 20½ out |
| Monday, August 26 |
| » Major-league debuts: Dwight Siebler (Twins) |
| Tuesday, August 27 |
| » Lost to White Sox (72-58), 6-1 | Cleveland Stadium (33-33) | 64-69 | |
| » Starters: Joe Horlen vs Mudcat Grant | Fifth | 22 out |
| Wednesday, August 28 |
| » Lost to White Sox (73-58), 8-3 | Cleveland Stadium (33-34) | 64-70 | Lost 2 |
| » Starters: Juan Pizarro vs Pedro Ramos | Sixth | 23½ out |
| » Lost to White Sox (74-58), 3-1 | Cleveland Stadium (33-35) | 64-71 | Lost 3 |
| » Starters: Eddie Fisher vs Dick Donovan | Sixth | 23½ out |
| Thursday, August 29 |
| » Lost to White Sox (75-58), 7-2 | Cleveland Stadium (33-36) | 64-72 | Lost 4 |
| » Starters: Gary Peters vs Barry Latman | Seventh | 23½ out |
| Friday, August 30 |
| » Defeated Tigers (64-67), 5-4 | Cleveland Stadium (34-36) | 65-72 | |
| » Starters: Jim Bunning vs Jack Kralick | Sixth | 23½ out |
| Saturday, August 31 |
| » Lost to Tigers (65-67), 9-8 | Cleveland Stadium (34-37) | 65-73 | |
| » Starters: Phil Regan vs Mudcat Grant | Seventh | 24½ out |
| Sunday, September 1 |
| » Defeated Tigers (65-68), 6-3 | Cleveland Stadium (35-37) | 66-73 | |
| » Starters: Don Mossi vs Dick Donovan | Sixth | 24 out |
| » Defeated Tigers (65-69), 3-1 | Cleveland Stadium (36-37) | 67-73 | Won 2 |
| » Starters: Mickey Lolich vs Pedro Ramos | Sixth | 24 out |
| Monday, September 2 |
| » Defeated Senators (49-88), 15-3 | Cleveland Stadium (37-37) | 68-73 | Won 3 |
| » Starters: Don Rudolph vs Jack Kralick | Seventh | 24 out |
| » Lost to Senators (50-88), 8-7 | Cleveland Stadium (37-38) | 68-74 | |
| » Starters: Ed Hobaugh vs Barry Latman | Seventh | 24 out |
| Wednesday, September 4 |
| » Lost to Orioles (75-66), 6-5 | Cleveland Stadium (37-39) | 68-75 | Lost 2 |
| » Starters: Robin Roberts vs Mudcat Grant | Seventh | 24½ out |
| » Major-league debuts: Bob Chance (Indians) |
| Friday, September 6 |
| » Lost to Senators (51-90), 7-2 | Robert F. Kennedy Stadium (4-3) | 68-76 | Lost 3 |
| » Starters: Dick Donovan vs Bennie Daniels | Sixth | 26 out |
| » Major-league debuts: Tommy John (Indians) |
| Saturday, September 7 |
| » Defeated Senators (51-91), 9-2 | Robert F. Kennedy Stadium (5-3) | 69-76 | |
| » Starters: Pedro Ramos vs Don Rudolph | Sixth | 26 out |
| Sunday, September 8 |
| » Defeated Senators (51-92), 6-2 | Robert F. Kennedy Stadium (6-3) | 70-76 | Won 2 |
| » Starters: Jack Kralick vs Jim Duckworth | Sixth | 26 out |
| Former Indian Bill Knickerbocker dies in Sebastopol, CA at the age of 52. |
| Monday, September 9 |
| » Lost to Twins (81-64), 7-4 | Metropolitan Stadium (1-5) | 70-77 | |
| » Starters: Mudcat Grant vs Jim Perry | Seventh | 26 out |
| Tuesday, September 10 |
| » Lost to Twins (82-64), 5-4 | Metropolitan Stadium (1-6) | 70-78 | Lost 2 |
| » Starters: Barry Latman vs Jim Kaat | Seventh | 26 out |
| Wednesday, September 11 |
| » Lost to Twins (83-64), 9-3 | Metropolitan Stadium (1-7) | 70-79 | Lost 3 |
| » Starters: Dick Donovan vs Lee Stange | Seventh | 27 out |
| Thursday, September 12 |
| » Lost to Twins (84-64), 3-2 | Metropolitan Stadium (1-8) | 70-80 | Lost 4 |
| » Starters: Pedro Ramos vs Dwight Siebler | Seventh | 28 out |
| Friday, September 13 |
| » Defeated Angels (67-83), 7-6 | Dodger Stadium (4-3) | 71-80 | |
| » Starters: Jack Kralick vs Fred Newman | Sixth | 28 out |
| Saturday, September 14 |
| » Lost to Angels (68-83), 4-3 | Dodger Stadium (4-4) | 71-81 | |
| » Starters: Tommy John vs Dean Chance | Seventh | 28½ out |
| Sunday, September 15 |
| » Defeated Angels (68-84), 6-3 | Dodger Stadium (5-4) | 72-81 | |
| » Starters: Mudcat Grant vs Bo Belinsky | Seventh | 28½ out |
| Tuesday, September 17 |
|
