| Saturday, January 5 |
| Former Giant Rogers Hornsby dies in Chicago, IL at the age of 67. |
| Thursday, January 31 |
| Future Giant Francisco Oliveras is born in Santurce, P.R. |
| Saturday, February 9 |
| Former Giant Ray Starr dies in Baylis, IL at the age of 57. |
| Friday, February 15 |
| Former Giant Bump Hadley dies in Lynn, MA at the age of 59. |
| Friday, March 1 |
| Future Giant Rich Rodriguez is born in Downey, CA. Former Giant Irish Meusel dies in Long Beach, CA at the age of 70. |
| Saturday, March 9 |
| Future Giant Terry Mulholland is born in Uniontown, PA. |
| Wednesday, March 20 |
| Future Giant Rick Parker is born in Kansas City, MO. |
| Thursday, March 21 |
| Future Giant Shawon Dunston is born in Brooklyn, NY. |
| Friday, March 22 |
| Future Giant Rich Monteleone is born in Tampa, FL. |
| Monday, April 8 |
| » Major-league debuts: Tom Brown (Senators) |
| Tuesday, April 9 |
| » Defeated Astros (0-1), 9-2 | Colt Stadium (1-0) | 1-0 | |
| » Starters: Jack Sanford vs Turk Farrell | First | -- |
| » Major-league debuts: Brock Davis and Rusty Staub (Astros) |
| Wednesday, April 10 |
| » Defeated Astros (0-2), 8-7 | Colt Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Juan Marichal vs Bob Bruce | First | -- |
| Thursday, April 11 |
| » Defeated Astros (0-3), 7-1 | Colt Stadium (3-0) | 3-0 | Won 3 |
| » Starters: Billy O'Dell vs Ken Johnson | First | -- |
| » Major-league debuts: Chris Zachary (Astros) |
| Saturday, April 13 |
| » Defeated Cubs (1-3), 2-1 | Wrigley Field (1-0) | 4-0 | Won 4 |
| » Starters: Jack Sanford vs Glen Hobbie | First | -- |
| Future Giant Mark Leiter is born in Joliet, IL. |
| Sunday, April 14 |
| » Lost to Cubs (2-3), 3-1 | Wrigley Field (1-1) | 4-1 | |
| » Starters: Juan Marichal vs Larry Jackson | First | -- |
| » Major-league debuts: Jose Cardenal (Giants) |
| Tuesday, April 16 |
| » Defeated Astros (2-5), 7-0 | Candlestick Park (1-0) | 5-1 | |
| » Starters: Bob Bruce vs Billy Pierce | First | -- |
| Wednesday, April 17 |
| » Lost to Astros (3-5), 2-1 | Candlestick Park (1-1) | 5-2 | |
| » Starters: Ken Johnson vs Billy O'Dell | Second | ½ out |
| Thursday, April 18 |
| » Defeated Astros (3-6), 6-3 | Candlestick Park (2-1) | 6-2 | |
| » Starters: George Brunet vs Jack Sanford | Second | ½ out |
| Friday, April 19 |
| » Defeated Cubs (4-5), 5-1 | Candlestick Park (3-1) | 7-2 | Won 2 |
| » Starters: Larry Jackson vs Juan Marichal | First | -- |
| Saturday, April 20 |
| » Lost to Cubs (5-5), 4-0 | Candlestick Park (3-2) | 7-3 | |
| » Starters: Bob Buhl vs Billy Pierce | First | -- |
| Sunday, April 21 |
| » Lost to Cubs (6-5), 4-1 | Candlestick Park (3-3) | 7-4 | Lost 2 |
| » Starters: Dick Ellsworth vs Jack Fisher | First | -- |
| » Defeated Cubs (6-6), 3-2 | Candlestick Park (4-3) | 8-4 | |
| » Starters: Cal Koonce vs Billy O'Dell | First | -- |
| Monday, April 22 |
| » Lost to Reds (5-5), 7-4 | Candlestick Park (4-4) | 8-5 | |
| » Starters: Jim O'Toole vs Jack Sanford | Second | 1 out |
| Tuesday, April 23 |
| » Defeated Reds (5-6), 4-2 | Candlestick Park (5-4) | 9-5 | |
| » Starters: Joe Nuxhall vs Juan Marichal | First | -- |
| Wednesday, April 24 |
| » Lost to Cardinals (10-5), 4-3 | Candlestick Park (5-5) | 9-6 | |
| » Starters: Curt Simmons vs Billy Pierce | Third | 1 out |
| Thursday, April 25 |
| » Defeated Cardinals (10-6), 8-4 | Candlestick Park (6-5) | 10-6 | |
| » Starters: Ray Sadecki vs Billy O'Dell | First | -- |
| Friday, April 26 |
| » Lost to Braves (10-8), 9-2 | Candlestick Park (6-6) | 10-7 | |
| » Starters: Lew Burdette vs Jack Fisher | Third | 1 out |
| Saturday, April 27 |
| » Lost to Braves (11-8), 6-5 | Candlestick Park (6-7) | 10-8 | Lost 2 |
| » Starters: Bob Hendley vs Jack Sanford | Fourth | 2 out |
| Sunday, April 28 |
| » Lost to Braves (12-8), 3-1 | Candlestick Park (6-8) | 10-9 | Lost 3 |
| » Starters: Warren Spahn vs Juan Marichal | Fourth | 2½ out |
| Monday, April 29 |
| » Defeated Phillies (8-10), 4-3 | Shibe Park (1-0) | 11-9 | |
| » Starters: Jack Fisher vs Cal McLish | Fourth | 2 out |
| Wednesday, May 1 |
| » Defeated Pirates (11-6), 5-1 | Forbes Field (1-0) | 12-9 | Won 2 |
| » Starters: Jack Sanford vs Bob Friend | Third | 2 out |
| Thursday, May 2 |
| » Defeated Pirates (11-7), 2-1 | Forbes Field (2-0) | 13-9 | Won 3 |
| » Starters: Juan Marichal vs Don Cardwell | Third | 2 out |
| Friday, May 3 |
| » Defeated Mets (8-13), 5-3 | Polo Grounds V (1-0) | 14-9 | Won 4 |
| » Starters: Jack Fisher vs Jay Hook | Third | 1 out |
| Saturday, May 4 |
| » Defeated Mets (8-14), 17-4 | Polo Grounds V (2-0) | 15-9 | Won 5 |
| » Starters: Billy O'Dell vs Roger Craig | Second | 2 out |
| Sunday, May 5 |
| » Defeated Mets (8-15), 6-3 | Polo Grounds V (3-0) | 16-9 | Won 6 |
| » Starters: Jack Sanford vs Galen Cisco | Second | 2½ out |
| » Lost to Mets (9-15), 4-2 | Polo Grounds V (3-1) | 16-10 | |
| » Starters: Billy Pierce vs Carl Willey | Second | 2½ out |
| Tuesday, May 7 |
| » Defeated Braves (13-14), 5-2 | County Stadium (1-0) | 17-10 | |
| » Starters: Juan Marichal vs Lew Burdette | First | -- |
| Wednesday, May 8 |
| » Defeated Braves (13-15), 12-5 | County Stadium (2-0) | 18-10 | Won 2 |
| » Starters: Jack Fisher vs Bob Hendley | First | -- |
| Thursday, May 9 |
| » Defeated Braves (13-16), 8-2 | County Stadium (3-0) | 19-10 | Won 3 |
| » Starters: Billy O'Dell vs Warren Spahn | First | -- |
| Friday, May 10 |
| » Lost to Dodgers (15-15), 2-1 | Dodger Stadium (0-1) | 19-11 | |
| » Starters: Jack Sanford vs Don Drysdale | First | -- |
| Saturday, May 11 |
| » Lost to Dodgers (16-15), 8-0 | Dodger Stadium (0-2) | 19-12 | Lost 2 |
| » Starters: Juan Marichal vs Sandy Koufax | First | -- |
| Sunday, May 12 |
| » Lost to Dodgers (17-15), 6-5 | Dodger Stadium (0-3) | 19-13 | Lost 3 |
| » Starters: Jack Fisher vs Johnny Podres | First | -- |
| Tuesday, May 14 |
| » Defeated Pirates (16-14), 3-1 | Candlestick Park (7-8) | 20-13 | |
| » Starters: Bob Friend vs Jack Sanford | First | -- |
| Wednesday, May 15 |
| » Defeated Pirates (16-15), 4-3 | Candlestick Park (8-8) | 21-13 | Won 2 |
| » Starters: Don Cardwell vs Juan Marichal | First | -- |
| Thursday, May 16 |
| » Defeated Mets (15-20), 6-5 | Candlestick Park (9-8) | 22-13 | Won 3 |
| » Starters: Jay Hook vs Billy O'Dell | First | -- |
| Friday, May 17 |
| » Defeated Mets (15-21), 4-3 | Candlestick Park (10-8) | 23-13 | Won 4 |
| » Starters: Galen Cisco vs Billy Pierce | First | -- |
| Saturday, May 18 |
| » Lost to Mets (16-21), 4-0 | Candlestick Park (10-9) | 23-14 | |
| » Starters: Carl Willey vs Jack Sanford | First | -- |
| Sunday, May 19 |
| » Lost to Phillies (17-19), 3-0 | Candlestick Park (10-10) | 23-15 | Lost 2 |
| » Starters: Cal McLish vs Jack Fisher | First | -- |
| » Defeated Phillies (17-20), 6-5 | Candlestick Park (11-10) | 24-15 | |
| » Starters: John Boozer vs Juan Marichal | First | -- |
| Tuesday, May 21 |
| » Defeated Phillies (17-21), 3-2 | Candlestick Park (12-10) | 25-15 | Won 2 |
| » Starters: Ray Culp vs Billy O'Dell | First | -- |
| Wednesday, May 22 |
| » Defeated Phillies (17-22), 10-2 | Candlestick Park (13-10) | 26-15 | Won 3 |
| » Starters: Dallas Green vs Jack Sanford | First | -- |
| Friday, May 24 |
| » Defeated Dodgers (25-17), 7-1 | Candlestick Park (14-10) | 27-15 | Won 4 |
| » Starters: Sandy Koufax vs Juan Marichal | First | -- |
| Saturday, May 25 |
| » Defeated Dodgers (25-18), 6-2 | Candlestick Park (15-10) | 28-15 | Won 5 |
| » Starters: Johnny Podres vs Billy O'Dell | First | -- |
| Sunday, May 26 |
| » Lost to Dodgers (26-18), 4-3 | Candlestick Park (15-11) | 28-16 | |
| » Starters: Don Drysdale vs Jack Sanford | First | -- |
| Tuesday, May 28 |
| » Lost to Reds (21-21), 10-6 | Crosley Field (0-1) | 28-17 | Lost 2 |
| » Starters: Jack Fisher vs Jim O'Toole | First | -- |
| Wednesday, May 29 |
| » Defeated Reds (21-22), 5-4 | Crosley Field (1-1) | 29-17 | |
| » Starters: Juan Marichal vs Bob Purkey | First | -- |
| Thursday, May 30 |
| » Defeated Reds (21-23), 5-4 | Crosley Field (2-1) | 30-17 | Won 2 |
| » Starters: Billy O'Dell vs Joe Nuxhall | First | -- |
| Friday, May 31 |
| » Lost to Cardinals (29-21), 6-5 | Sportsman's Park III (0-1) | 30-18 | |
| » Starters: Jack Sanford vs Curt Simmons | First | -- |
| Saturday, June 1 |
| » Lost to Cardinals (30-21), 7-4 | Sportsman's Park III (0-2) | 30-19 | Lost 2 |
| » Starters: Jack Fisher vs Ron Taylor | First | -- |
| Sunday, June 2 |
| » Defeated Cardinals (30-22), 6-4 | Sportsman's Park III (1-2) | 31-19 | |
| » Starters: Juan Marichal vs Ernie Broglio | First | -- |
| Tuesday, June 4 |
| » Lost to Cubs (28-23), 6-1 | Wrigley Field (1-2) | 31-20 | |
| » Starters: Billy O'Dell vs Bob Buhl | First | -- |
| Wednesday, June 5 |
| » Lost to Cubs (29-23), 9-5 | Wrigley Field (1-3) | 31-21 | Lost 2 |
| » Starters: Jack Fisher vs Dick Ellsworth | First | -- |
| » Lost to Cubs (30-23), 5-4 | Wrigley Field (1-4) | 31-22 | Lost 3 |
| » Starters: Jack Sanford vs Glen Hobbie | First | -- |
| Thursday, June 6 |
| » Lost to Cubs (31-23), 3-2 | Wrigley Field (1-5) | 31-23 | Lost 4 |
| » Starters: Juan Marichal vs Larry Jackson | First | -- |
| Friday, June 7 |
| » Lost to Astros (23-32), 2-1 | Colt Stadium (3-1) | 31-24 | Lost 5 |
| » Starters: Bobby Bolin vs Don Nottebart | Second | 1 out |
| Saturday, June 8 |
| » Lost to Astros (24-32), 2-1 | Colt Stadium (3-2) | 31-25 | Lost 6 |
| » Starters: Billy O'Dell vs Bob Bruce | Third | 1 out |
| Former Giant Earl Smith dies in Little Rock, AR at the age of 67. |
| Sunday, June 9 |
| » Lost to Astros (25-32), 3-0 | Colt Stadium (3-3) | 31-26 | Lost 7 |
| » Starters: Jack Sanford vs Turk Farrell | Third | 2 out |
| Monday, June 10 |
| » Defeated Dodgers (32-24), 7-3 | Dodger Stadium (1-3) | 32-26 | |
| » Starters: Billy Pierce vs Bob Miller | Third | 1 out |
| Tuesday, June 11 |
| » Defeated Dodgers (32-25), 3-0 | Dodger Stadium (2-3) | 33-26 | Won 2 |
| » Starters: Juan Marichal vs Don Drysdale | Third | 1 out |
| Wednesday, June 12 |
| » Defeated Cubs (32-28), 3-1 | Candlestick Park (16-11) | 34-26 | Won 3 |
| » Starters: Bob Buhl vs Bobby Bolin | Second | 1 out |
| Thursday, June 13 |
| » Defeated Cubs (32-29), 2-1 | Candlestick Park (17-11) | 35-26 | Won 4 |
| » Starters: Dick Ellsworth vs Billy O'Dell | Second | 1 out |
| Friday, June 14 |
| » Defeated Astros (26-36), 2-1 | Candlestick Park (18-11) | 36-26 | Won 5 |
| » Starters: Hal Brown vs Jack Sanford | First | -- |
| Saturday, June 15 |
| » Defeated Astros (26-37), 1-0 | Candlestick Park (19-11) | 37-26 | Won 6 |
| » Starters: Dick Drott vs Juan Marichal | First | -- |
| Sunday, June 16 |
| » Lost to Astros (27-37), 3-0 | Candlestick Park (19-12) | 37-27 | |
| » Starters: Don Nottebart vs Bobby Bolin | First | -- |
| » Defeated Astros (27-38), 4-3 | Candlestick Park (20-12) | 38-27 | |
| » Starters: Ken Johnson vs Gaylord Perry | First | -- |
| Monday, June 17 |
| » Lost to Dodgers (37-27), 2-0 | Candlestick Park (20-13) | 38-28 | |
| » Starters: Sandy Koufax vs Billy O'Dell | Third | ½ out |
| Tuesday, June 18 |
| » Defeated Dodgers (37-28), 9-3 | Candlestick Park (21-13) | 39-28 | |
| » Starters: Bob Miller vs Jack Sanford | Second | ½ out |
| Wednesday, June 19 |
| » Defeated Dodgers (37-29), 8-3 | Candlestick Park (22-13) | 40-28 | Won 2 |
| » Starters: Don Drysdale vs Juan Marichal | Second | ½ out |
| Friday, June 21 |
| » Lost to Braves (33-34), 6-3 | County Stadium (3-1) | 40-29 | |
| » Starters: Bobby Bolin vs Tony Cloninger | Second | ½ out |
| Saturday, June 22 |
| » Defeated Braves (33-35), 3-0 | County Stadium (4-1) | 41-29 | |
| » Starters: Billy O'Dell vs Bob Shaw | Second | ½ out |
| Sunday, June 23 |
| » Lost to Braves (34-35), 10-4 | County Stadium (4-2) | 41-30 | |
| » Starters: Jack Sanford vs Warren Spahn | Second | ½ out |
| Monday, June 24 |
| » Defeated Cardinals (41-30), 4-3 | Sportsman's Park III (2-2) | 42-30 | |
| » Starters: Juan Marichal vs Lew Burdette | First | -- |
| Tuesday, June 25 |
| » Lost to Cardinals (42-30), 6-5 | Sportsman's Park III (2-3) | 42-31 | |
| » Starters: Jim Duffalo vs Ray Sadecki | Third | ½ out |
| Wednesday, June 26 |
| » Lost to Cardinals (43-30), 6-5 | Sportsman's Park III (2-4) | 42-32 | Lost 2 |
| » Starters: Billy O'Dell vs Curt Simmons | Third | 1½ out |
| Friday, June 28 |
| » Defeated Reds (40-34), 7-3 | Candlestick Park (23-13) | 43-32 | |
| » Starters: Bob Purkey vs Juan Marichal | Third | 1½ out |
| Saturday, June 29 |
| » Lost to Reds (41-34), 7-3 | Candlestick Park (23-14) | 43-33 | |
| » Starters: Joe Nuxhall vs Jack Sanford | Third | 2½ out |
| Sunday, June 30 |
| » Defeated Reds (41-35), 7-3 | Candlestick Park (24-14) | 44-33 | |
| » Starters: Jim O'Toole vs Billy Pierce | Third | 1½ out |
| Monday, July 1 |
| » Lost to Reds (42-35), 4-3 | Candlestick Park (24-15) | 44-34 | |
| » Starters: Jim Maloney vs Billy O'Dell | Third | 1½ out |
| Tuesday, July 2 |
| » Defeated Braves (38-39), 1-0 | Candlestick Park (25-15) | 45-34 | |
| » Starters: Warren Spahn vs Jack Sanford | Third | 1 out |
| Wednesday, July 3 |
| » Lost to Braves (39-39), 6-5 | Candlestick Park (25-16) | 45-35 | |
| » Starters: Denny Lemaster vs Juan Marichal | Third | 2 out |
| Thursday, July 4 |
| » Lost to Braves (40-39), 6-3 | Candlestick Park (25-17) | 45-36 | Lost 2 |
| » Starters: Tony Cloninger vs Jack Fisher | Fourth | 3 out |
| Friday, July 5 |
| » Defeated Cardinals (45-36), 6-5 | Candlestick Park (26-17) | 46-36 | |
| » Starters: Lew Burdette vs Billy O'Dell | Third | 3 out |
| Saturday, July 6 |
| » Defeated Cardinals (45-37), 5-3 | Candlestick Park (27-17) | 47-36 | Won 2 |
| » Starters: Ray Sadecki vs Billy Pierce | Second | 2 out |
| Sunday, July 7 |
| » Defeated Cardinals (45-38), 4-3 | Candlestick Park (28-17) | 48-36 | Won 3 |
| » Starters: Curt Simmons vs Jack Sanford | Second | 3 out |
| » Lost to Cardinals (46-38), 5-0 | Candlestick Park (28-18) | 48-37 | |
| » Starters: Bob Gibson vs Juan Marichal | Second | 3 out |
| » Major-league debuts: Jim Ray Hart (Giants) |
| Wednesday, July 10 |
| » Lost to Phillies (41-44), 10-2 | Shibe Park (1-1) | 48-38 | Lost 2 |
| » Starters: Billy O'Dell vs Cal McLish | Second | 4 out |
| Thursday, July 11 |
| » Defeated Phillies (41-45), 4-3 | Shibe Park (2-1) | 49-38 | |
| » Starters: Juan Marichal vs Ray Culp | Second | 4 out |
| Friday, July 12 |
| » Lost to Phillies (42-45), 7-5 | Shibe Park (2-2) | 49-39 | |
| » Starters: Jack Sanford vs Art Mahaffey | Second | 5 out |
| Saturday, July 13 |
| » Lost to Phillies (43-45), 4-3 | Shibe Park (2-3) | 49-40 | Lost 2 |
| » Starters: Billy Pierce vs Ryne Duren | Second | 6 out |
| Monday, July 15 |
| » Lost to Pirates (45-43), 2-1 | Forbes Field (2-1) | 49-41 | Lost 3 |
| » Starters: Juan Marichal vs Bob Friend | Third | 7 out |
| » Lost to Pirates (46-43), 4-1 | Forbes Field (2-2) | 49-42 | Lost 4 |
| » Starters: Billy O'Dell vs Joe Gibbon | Third | 7 out |
| Tuesday, July 16 |
| » Defeated Pirates (46-44), 3-2 | Forbes Field (3-2) | 50-42 | |
| » Starters: Bobby Bolin vs Don Cardwell | Fourth | 7 out |
| » Lost to Pirates (47-44), 3-2 | Forbes Field (3-3) | 50-43 | |
| » Starters: Jack Sanford vs Don Schwall | Fourth | 7 out |
| Wednesday, July 17 |
| » Lost to Mets (32-61), 9-7 | Polo Grounds V (3-2) | 50-44 | Lost 2 |
| » Starters: Gaylord Perry vs Tracy Stallard | Fourth | 8 out |
| Thursday, July 18 |
| » Defeated Mets (32-62), 6-5 | Polo Grounds V (4-2) | 51-44 | |
| » Starters: Jim Duffalo vs Larry Bearnarth | Fourth | 8 out |
| Friday, July 19 |
| » Lost to Reds (51-45), 5-2 | Crosley Field (2-2) | 51-45 | |
| » Starters: Billy Pierce vs John Tsitouris | Fourth | 9 out |
| Future Giant Mark Carreon is born in Chicago, IL. |
| Saturday, July 20 |
| » Lost to Reds (52-45), 3-2 | Crosley Field (2-3) | 51-46 | Lost 2 |
| » Starters: Jack Sanford vs Joe Nuxhall | Fifth | 10 out |
| Sunday, July 21 |
| » Defeated Reds (52-46), 10-5 | Crosley Field (3-3) | 52-46 | |
| » Starters: Billy O'Dell vs Jim O'Toole | Fourth | 8½ out |
| Tuesday, July 23 |
| » Defeated Mets (32-67), 9-1 | Candlestick Park (29-18) | 53-46 | Won 2 |
| » Starters: Roger Craig vs Juan Marichal | Fourth | 8½ out |
| Wednesday, July 24 |
| » Defeated Mets (32-68), 4-3 | Candlestick Park (30-18) | 54-46 | Won 3 |
| » Starters: Al Jackson vs Jack Sanford | Fourth | 8½ out |
| Thursday, July 25 |
| » Defeated Mets (32-69), 8-6 | Candlestick Park (31-18) | 55-46 | Won 4 |
| » Starters: Galen Cisco vs Billy Pierce | Third | 7½ out |
| Friday, July 26 |
| » Defeated Pirates (50-50), 6-4 | Candlestick Park (32-18) | 56-46 | Won 5 |
| » Starters: Don Cardwell vs Billy O'Dell | Third | 6½ out |
| Saturday, July 27 |
| » Defeated Pirates (50-51), 3-1 | Candlestick Park (33-18) | 57-46 | Won 6 |
| » Starters: Bob Friend vs Juan Marichal | Third | 5½ out |
| Sunday, July 28 |
| » Defeated Pirates (50-52), 3-1 | Candlestick Park (34-18) | 58-46 | Won 7 |
| » Starters: Don Schwall vs Jack Sanford | Second | 4½ out |
| Monday, July 29 |
| » Defeated Pirates (50-53), 5-4 | Candlestick Park (35-18) | 59-46 | Won 8 |
| » Starters: Earl Francis vs Gaylord Perry | Second | 4½ out |
| Future Giant Steve Frey is born in Meadowbrook, PA. |
| Tuesday, July 30 |
| » Defeated Phillies (55-51), 5-0 | Candlestick Park (36-18) | 60-46 | Won 9 |
| » Starters: Ray Culp vs Billy O'Dell | Second | 3½ out |
| Wednesday, July 31 |
| » Lost to Phillies (56-51), 7-3 | Candlestick Park (36-19) | 60-47 | |
| » Starters: Chris Short vs Juan Marichal | Second | 4½ out |
| Friday, August 2 |
| » Lost to Cubs (58-48), 12-11 | Wrigley Field (1-6) | 60-48 | Lost 2 |
| » Starters: Jack Sanford vs Dick Ellsworth | Third | 4½ out |
| » Major-league debuts: Tom Baker (Cubs) |
| Saturday, August 3 |
| » Defeated Cubs (58-49), 9-5 | Wrigley Field (2-6) | 61-48 | |
| » Starters: Jack Sanford vs Bob Buhl | Third | 4½ out |
| Sunday, August 4 |
| » Defeated Cubs (58-50), 2-1 | Wrigley Field (3-6) | 62-48 | Won 2 |
| » Starters: Billy O'Dell vs Paul Toth | Second | 4½ out |
| Monday, August 5 |
| » Lost to Astros (43-69), 6-5 | Colt Stadium (3-4) | 62-49 | |
| » Starters: Juan Marichal vs Don Nottebart | Second | 5 out |
| Tuesday, August 6 |
| » Defeated Astros (43-70), 3-1 | Colt Stadium (4-4) | 63-49 | |
| » Starters: Jim Duffalo vs Hal Brown | Second | 5 out |
| Wednesday, August 7 |
| » Lost to Astros (44-70), 1-0 | Colt Stadium (4-5) | 63-50 | |
| » Starters: Jack Sanford vs Turk Farrell | Second | 6 out |
| Friday, August 9 |
| » Defeated Phillies (60-56), 4-0 | Shibe Park (3-3) | 64-50 | |
| » Starters: Juan Marichal vs Ray Culp | Second | 4½ out |
| Saturday, August 10 |
| » Defeated Phillies (60-57), 7-6 | Shibe Park (4-3) | 65-50 | Won 2 |
| » Starters: Billy O'Dell vs Dennis Bennett | Second | 4½ out |
| Sunday, August 11 |
| » Defeated Phillies (60-58), 5-1 | Shibe Park (5-3) | 66-50 | Won 3 |
| » Starters: Jack Sanford vs Cal McLish | Second | 3½ out |
| Monday, August 12 |
| » Lost to Phillies (61-58), 3-1 | Shibe Park (5-4) | 66-51 | |
| » Starters: Jim Duffalo vs Chris Short | Second | 4 out |
| Tuesday, August 13 |
| » Lost to Reds (65-56), 4-0 | Crosley Field (3-4) | 66-52 | Lost 2 |
| » Starters: Juan Marichal vs Jim Maloney | Second | 4 out |
| Wednesday, August 14 |
| » Defeated Reds (65-57), 7-6 | Crosley Field (4-4) | 67-52 | |
| » Starters: Frank Linzy vs John Tsitouris | Second | 3 out |
| » Major-league debuts: Frank Linzy (Giants) |
| Thursday, August 15 |
| » Defeated Reds (65-58), 6-3 | Crosley Field (5-4) | 68-52 | Won 2 |
| » Starters: Jack Sanford vs Joe Nuxhall | Second | 3 out |
| Friday, August 16 |
| » Lost to Cardinals (67-54), 13-0 | Sportsman's Park III (2-5) | 68-53 | |
| » Starters: Jim Duffalo vs Curt Simmons | Second | 4 out |
| Saturday, August 17 |
| » Lost to Cardinals (68-54), 8-7 | Sportsman's Park III (2-6) | 68-54 | Lost 2 |
| » Starters: Juan Marichal vs Ernie Broglio | Second | 5 out |
| Monday, August 19 |
| » Lost to Cardinals (69-54), 8-7 | Sportsman's Park III (2-7) | 68-55 | Lost 3 |
| » Starters: Jack Sanford vs Bob Gibson | Third | 6½ out |
| Tuesday, August 20 |
| » Lost to Braves (65-60), 6-1 | Candlestick Park (36-20) | 68-56 | Lost 4 |
| » Starters: Bob Sadowski vs Billy Pierce | Third | 7½ out |
| Wednesday, August 21 |
| » Lost to Braves (66-60), 6-2 | Candlestick Park (36-21) | 68-57 | Lost 5 |
| » Starters: Bob Hendley vs Gaylord Perry | Third | 8½ out |
| Thursday, August 22 |
| » Defeated Braves (66-61), 8-6 | Candlestick Park (37-21) | 69-57 | |
| » Starters: Tony Cloninger vs Juan Marichal | Third | 7½ out |
| Friday, August 23 |
| » Defeated Reds (68-63), 11-3 | Candlestick Park (38-21) | 70-57 | Won 2 |
| » Starters: Jim Maloney vs Jack Sanford | Third | 6½ out |
| Saturday, August 24 |
| » Defeated Reds (68-64), 4-3 | Candlestick Park (39-21) | 71-57 | Won 3 |
| » Starters: John Tsitouris vs Billy O'Dell | Second | 5½ out |
| Sunday, August 25 |
| » Lost to Reds (69-64), 8-7 | Candlestick Park (39-22) | 71-58 | |
| » Starters: Joe Nuxhall vs Billy Pierce | Second | 6½ out |
| Monday, August 26 |
| » Lost to Cardinals (72-58), 6-3 | Candlestick Park (39-23) | 71-59 | Lost 2 |
| » Starters: Ernie Broglio vs Juan Marichal | Third | 6½ out |
| Tuesday, August 27 |
| » Defeated Cardinals (72-59), 7-2 | Candlestick Park (40-23) | 72-59 | |
| » Starters: Curt Simmons vs Jack Sanford | Second | 6½ out |
| Wednesday, August 28 |
| » Defeated Cardinals (72-60), 5-3 | Candlestick Park (41-23) | 73-59 | Won 2 |
| » Starters: Bob Gibson vs Billy O'Dell | Second | 5½ out |
| Thursday, August 29 |
| » Lost to Dodgers (79-53), 11-1 | Dodger Stadium (2-4) | 73-60 | |
| » Starters: Bobby Bolin vs Sandy Koufax | Second | 6½ out |
| Friday, August 30 |
| » Lost to Dodgers (80-53), 3-1 | Dodger Stadium (2-5) | 73-61 | Lost 2 |
| » Starters: Juan Marichal vs Don Drysdale | Third | 7½ out |
| Saturday, August 31 |
| » Defeated Dodgers (80-54), 4-3 | Dodger Stadium (3-5) | 74-61 | |
| » Starters: Jack Sanford vs Bob Miller | Third | 6½ out |
| Sunday, September 1 |
| » Lost to Dodgers (81-54), 5-3 | Dodger Stadium (3-6) | 74-62 | |
| » Starters: Billy O'Dell vs Pete Richert | Third | 7½ out |
| Monday, September 2 |
| » Lost to Cubs (71-65), 7-5 | Candlestick Park (41-24) | 74-63 | Lost 2 |
| » Starters: Dick Ellsworth vs Bobby Bolin | Third | 9½ out |
| » Lost to Cubs (72-65), 6-0 | Candlestick Park (41-25) | 74-64 | Lost 3 |
| » Starters: Glen Hobbie vs Jack Fisher | Third | 9½ out |
| » Major-league debuts: John Boccabella (Cubs) |
| Tuesday, September 3 |
| » Defeated Cubs (72-66), 16-3 | Candlestick Park (42-25) | 75-64 | |
| » Starters: Larry Jackson vs Juan Marichal | Third | 9½ out |
| » Major-league debuts: Jimmy Stewart (Cubs) |
| Wednesday, September 4 |
| » Defeated Astros (50-90), 8-3 | Candlestick Park (43-25) | 76-64 | Won 2 |
| » Starters: Dick Drott vs Jack Sanford | Third | 8½ out |
| Thursday, September 5 |
| » Lost to Astros (51-90), 5-2 | Candlestick Park (43-26) | 76-65 | |
| » Starters: Don Nottebart vs Bobby Bolin | Third | 9½ out |
| Future Giant Jeff Brantley is born in Florence, AL. |
| Friday, September 6 |
| » Lost to Dodgers (86-55), 5-2 | Candlestick Park (43-27) | 76-66 | Lost 2 |
| » Starters: Sandy Koufax vs Billy O'Dell | Fourth | 10½ out |
| Saturday, September 7 |
| » Defeated Dodgers (86-56), 5-3 | Candlestick Park (44-27) | 77-66 | |
| » Starters: Don Drysdale vs Juan Marichal | Fourth | 9½ out |
| Sunday, September 8 |
| » Defeated Dodgers (86-57), 5-4 | Candlestick Park (45-27) | 78-66 | Won 2 |
| » Starters: Bob Miller vs Jack Sanford | Fourth | 8½ out |
| Monday, September 9 |
| » Major-league debuts: Billy Cowan (Cubs) |
| Tuesday, September 10 |
| » Lost to Mets (48-97), 4-2 | Polo Grounds V (4-3) | 78-67 | |
| » Starters: Billy O'Dell vs Carl Willey | Fourth | 9½ out |
| » Major-league debuts: Jesus Alou and Ron Herbel (Giants) |
| Wednesday, September 11 |
| » Lost to Mets (49-97), 4-2 | Polo Grounds V (4-4) | 78-68 | Lost 2 |
| » Starters: Jack Sanford vs Al Jackson | Fourth | 10½ out |
| Thursday, September 12 |
| » Defeated Mets (49-98), 6-0 | Polo Grounds V (5-4) | 79-68 | |
| » Starters: Juan Marichal vs Tracy Stallard | Fourth | 10½ out |
| Friday, September 13 |
| » Lost to Pirates (70-77), 5-4 | Forbes Field (3-4) | 79-69 | |
| » Starters: Bobby Bolin vs Joe Gibbon | Fourth | 11 out |
| Saturday, September 14 |
| » Defeated Pirates (70-78), 7-3 | Forbes Field (4-4) | 80-69 | |
| » Starters: Jack Sanford vs Don Cardwell | Third | 11 out |
| Sunday, September 15 |
| » Defeated Pirates (70-79), 13-5 | Forbes Field (5-4) | 81-69 | Won 2 |
| » Starters: Billy O'Dell vs Don Schwall | Third | 10 out |
| Monday, September 16 |
| » Defeated Braves (80-72), 4-3 | County Stadium (5-2) | 82-69 | Won 3 |
| » Starters: Juan Marichal vs Tony Cloninger | Third | 10 out |
| Tuesday, September 17 |
| » Defeated Braves (80-73), 11-3 | County Stadium (6-2) | 83-69 | Won 4 |
| » Starters: Bobby Bolin vs Warren Spahn | Third | 10 out |
| » Major-league debuts: Wade Blasingame (Braves) |
| Wednesday, September 18 |
| » Lost to Braves (81-73), 6-4 | County Stadium (6-3) | 83-70 | |
| » Starters: Jack Sanford vs Bob Sadowski | Third | 11 out |
| Friday, September 20 |
| » Defeated Mets (49-105), 6-3 | Candlestick Park (46-27) | 84-70 | |
| » Starters: Carl Willey vs Juan Marichal | Third | 11 out |
| Saturday, September 21 |
| » Lost to Mets (50-105), 5-4 | Candlestick Park (46-28) | 84-71 | |
| » Starters: Al Jackson vs Billy O'Dell | Third | 12 out |
| Sunday, September 22 |
| » Defeated Mets (50-106), 13-4 | Candlestick Park (47-28) | 85-71 | |
| » Starters: Jay Hook vs Bobby Bolin | Third | 11 out |
| Tuesday, September 24 |
| » Lost to Phillies (83-74), 5-4 | Candlestick Park (47-29) | 85-72 | |
| » Starters: Dennis Bennett vs Juan Marichal | Third | 12 out |
| Wednesday, September 25 |
| » Lost to Phillies (84-74), 6-4 | Candlestick Park (47 |
