| Saturday, January 5 |
| Former Cardinal Rogers Hornsby dies in Chicago, IL at the age of 67. |
| Tuesday, January 29 |
| Former Cardinal Lee Meadows dies in Daytona Beach, FL at the age of 69. |
| Saturday, February 9 |
| Former Cardinal Ray Starr dies in Baylis, IL at the age of 57. |
| Saturday, February 23 |
| Future Cardinal Bobby Bonilla is born in Bronx, NY. |
| Friday, March 1 |
| Future Cardinal Rich Rodriguez is born in Downey, CA. |
| Thursday, March 21 |
| Future Cardinal Shawon Dunston is born in Brooklyn, NY. |
| Monday, April 8 |
| » Major-league debuts: Tom Brown (Senators) |
| Tuesday, April 9 |
| » Defeated Mets (0-1), 7-0 | Polo Grounds V (1-0) | 1-0 | |
| » Starters: Ernie Broglio vs Roger Craig | First | -- |
| » Major-league debuts: Al Moran (Mets) |
| Wednesday, April 10 |
| » Defeated Mets (0-2), 4-0 | Polo Grounds V (2-0) | 2-0 | Won 2 |
| » Starters: Ray Washburn vs Al Jackson | First | -- |
| Saturday, April 13 |
| » Defeated Phillies (2-1), 7-0 | Sportsman's Park III (1-0) | 3-0 | Won 3 |
| » Starters: Art Mahaffey vs Curt Simmons | Second | ½ out |
| Sunday, April 14 |
| » Lost to Phillies (3-1), 4-3 | Sportsman's Park III (1-1) | 3-1 | |
| » Starters: Chris Short vs Ernie Broglio | Second | 1 out |
| » Lost to Phillies (4-1), 5-4 | Sportsman's Park III (1-2) | 3-2 | Lost 2 |
| » Starters: Marcelino Lopez vs Ray Sadecki | Second | 1 out |
| » Major-league debuts: Marcelino Lopez (Phillies) |
| Tuesday, April 16 |
| » Defeated Pirates (4-2), 4-3 | Sportsman's Park III (2-2) | 4-2 | |
| » Starters: Earl Francis vs Bob Gibson | Third | 1 out |
| » Major-league debuts: Phil Gagliano (Cardinals) |
| Wednesday, April 17 |
| » Defeated Pirates (4-3), 7-3 | Sportsman's Park III (3-2) | 5-2 | Won 2 |
| » Starters: Don Cardwell vs Ray Washburn | Second | ½ out |
| Thursday, April 18 |
| » Lost to Pirates (5-3), 3-2 | Sportsman's Park III (3-3) | 5-3 | |
| » Starters: Don Schwall vs Ernie Broglio | Third | 1½ out |
| Friday, April 19 |
| » Defeated Phillies (4-5), 5-1 | Shibe Park (1-0) | 6-3 | |
| » Starters: Curt Simmons vs Chris Short | Third | 1 out |
| Saturday, April 20 |
| » Lost to Phillies (5-5), 6-2 | Shibe Park (1-1) | 6-4 | |
| » Starters: Ray Sadecki vs Marcelino Lopez | Fourth | 1 out |
| Sunday, April 21 |
| » Lost to Phillies (6-5), 4-3 | Shibe Park (1-2) | 6-5 | Lost 2 |
| » Starters: Ron Taylor vs Cal McLish | Third | 1 out |
| » Defeated Phillies (6-6), 10-5 | Shibe Park (2-2) | 7-5 | |
| » Starters: Bob Gibson vs Art Mahaffey | Third | 1 out |
| Monday, April 22 |
| » Defeated Astros (4-10), 5-2 | Colt Stadium (1-0) | 8-5 | Won 2 |
| » Starters: Ray Washburn vs Ken Johnson | Second | 1 out |
| Tuesday, April 23 |
| » Defeated Astros (4-11), 15-0 | Colt Stadium (2-0) | 9-5 | Won 3 |
| » Starters: Ernie Broglio vs Jim Golden | First | -- |
| Wednesday, April 24 |
| » Defeated Giants (9-6), 4-3 | Candlestick Park (1-0) | 10-5 | Won 4 |
| » Starters: Curt Simmons vs Billy Pierce | First | -- |
| Thursday, April 25 |
| » Lost to Giants (10-6), 8-4 | Candlestick Park (1-1) | 10-6 | |
| » Starters: Ray Sadecki vs Billy O'Dell | First | -- |
| Friday, April 26 |
| » Defeated Dodgers (10-8), 8-7 | Dodger Stadium (1-0) | 11-6 | |
| » Starters: Bob Gibson vs Don Drysdale | First | -- |
| Saturday, April 27 |
| » Defeated Dodgers (10-9), 3-0 | Dodger Stadium (2-0) | 12-6 | Won 2 |
| » Starters: Ray Washburn vs Larry Sherry | First | -- |
| Sunday, April 28 |
| » Defeated Dodgers (10-10), 9-5 | Dodger Stadium (3-0) | 13-6 | Won 3 |
| » Starters: Ernie Broglio vs Johnny Podres | Second | 1½ out |
| Tuesday, April 30 |
| » Defeated Braves (12-9), 2-1 | Sportsman's Park III (4-3) | 14-6 | Won 4 |
| » Starters: Denny Lemaster vs Curt Simmons | First | -- |
| Wednesday, May 1 |
| » Lost to Cubs (10-10), 13-8 | Sportsman's Park III (4-4) | 14-7 | |
| » Starters: Dick Ellsworth vs Ray Sadecki | First | -- |
| Thursday, May 2 |
| » Defeated Cubs (10-11), 4-3 | Sportsman's Park III (5-4) | 15-7 | |
| » Starters: Larry Jackson vs Ray Washburn | First | -- |
| Friday, May 3 |
| » Lost to Reds (8-11), 6-0 | Crosley Field (0-1) | 15-8 | |
| » Starters: Ernie Broglio vs Joe Nuxhall | First | -- |
| Saturday, May 4 |
| » Lost to Reds (9-11), 6-0 | Crosley Field (0-2) | 15-9 | Lost 2 |
| » Starters: Bob Gibson vs Jim Maloney | Second | 2 out |
| Sunday, May 5 |
| » Lost to Reds (10-11), 5-4 | Crosley Field (0-3) | 15-10 | Lost 3 |
| » Starters: Ray Sadecki vs Jim O'Toole | Second | 2½ out |
| » Defeated Reds (10-12), 7-4 | Crosley Field (1-3) | 16-10 | |
| » Starters: Curt Simmons vs Jim Owens | Second | 2½ out |
| Tuesday, May 7 |
| » Lost to Dodgers (13-14), 11-1 | Sportsman's Park III (5-5) | 16-11 | |
| » Starters: Sandy Koufax vs Ray Washburn | Third | 1 out |
| Wednesday, May 8 |
| » Lost to Dodgers (14-14), 11-5 | Sportsman's Park III (5-6) | 16-12 | Lost 2 |
| » Starters: Bob Miller vs Ernie Broglio | Fourth | 2 out |
| » Major-league debuts: Dick Scott (Dodgers) |
| Thursday, May 9 |
| » Defeated Dodgers (14-15), 10-7 | Sportsman's Park III (6-6) | 17-12 | |
| » Starters: Pete Richert vs Bob Gibson | Third | 2 out |
| Friday, May 10 |
| » Defeated Pirates (14-12), 1-0 | Forbes Field (1-0) | 18-12 | Won 2 |
| » Starters: Curt Simmons vs Bob Friend | Second | 1 out |
| Saturday, May 11 |
| » Lost to Pirates (15-12), 3-2 | Forbes Field (1-1) | 18-13 | |
| » Starters: Ray Washburn vs Vern Law | Second | 1 out |
| Sunday, May 12 |
| » Defeated Pirates (15-13), 2-1 | Forbes Field (2-1) | 19-13 | |
| » Starters: Ernie Broglio vs Joe Gibbon | Second | ½ out |
| » Lost to Pirates (16-13), 4-3 | Forbes Field (2-2) | 19-14 | |
| » Starters: Ray Sadecki vs Earl Francis | Second | ½ out |
| Tuesday, May 14 |
| » Lost to Braves (15-19), 4-3 | County Stadium (0-1) | 19-15 | Lost 2 |
| » Starters: Bob Gibson vs Warren Spahn | Second | 1½ out |
| Wednesday, May 15 |
| » Lost to Braves (16-19), 9-3 | County Stadium (0-2) | 19-16 | Lost 3 |
| » Starters: Curt Simmons vs Bob Hendley | Second | 2½ out |
| Thursday, May 16 |
| » Lost to Braves (17-19), 5-2 | County Stadium (0-3) | 19-17 | Lost 4 |
| » Starters: Ray Washburn vs Denny Lemaster | Fourth | 3½ out |
| Friday, May 17 |
| » Defeated Reds (15-18), 11-2 | Sportsman's Park III (7-6) | 20-17 | |
| » Starters: Joey Jay vs Ernie Broglio | Third | 3½ out |
| Saturday, May 18 |
| » Lost to Reds (16-18), 9-7 | Sportsman's Park III (7-7) | 20-18 | |
| » Starters: Bob Purkey vs Ray Sadecki | Third | 3½ out |
| Sunday, May 19 |
| » Lost to Reds (17-18), 10-6 | Sportsman's Park III (7-8) | 20-19 | Lost 2 |
| » Starters: Joe Nuxhall vs Bob Gibson | Fourth | 4 out |
| Tuesday, May 21 |
| » Defeated Cubs (19-19), 5-4 | Wrigley Field (1-0) | 21-19 | |
| » Starters: Curt Simmons vs Larry Jackson | Third | 4 out |
| Wednesday, May 22 |
| » Lost to Cubs (20-19), 7-6 | Wrigley Field (1-1) | 21-20 | |
| » Starters: Ray Washburn vs Bob Buhl | Fourth | 5 out |
| Thursday, May 23 |
| » Defeated Cubs (20-20), 1-0 | Wrigley Field (2-1) | 22-20 | |
| » Starters: Ernie Broglio vs Dick Ellsworth | Third | 4½ out |
| Friday, May 24 |
| » Defeated Mets (16-26), 10-4 | Sportsman's Park III (8-8) | 23-20 | Won 2 |
| » Starters: Roger Craig vs Bob Gibson | Third | 4½ out |
| Saturday, May 25 |
| » Defeated Mets (16-27), 6-3 | Sportsman's Park III (9-8) | 24-20 | Won 3 |
| » Starters: Al Jackson vs Ray Sadecki | Third | 4½ out |
| Sunday, May 26 |
| » Defeated Mets (16-28), 7-4 | Sportsman's Park III (10-8) | 25-20 | Won 4 |
| » Starters: Galen Cisco vs Curt Simmons | Third | 4 out |
| » Lost to Mets (17-28), 3-2 | Sportsman's Park III (10-9) | 25-21 | |
| » Starters: Carl Willey vs Ron Taylor | Third | 4 out |
| Tuesday, May 28 |
| » Defeated Astros (19-27), 8-7 | Sportsman's Park III (11-9) | 26-21 | |
| » Starters: Don Nottebart vs Ernie Broglio | Third | 3 out |
| Wednesday, May 29 |
| » Defeated Astros (19-28), 3-2 | Sportsman's Park III (12-9) | 27-21 | Won 2 |
| » Starters: Bob Bruce vs Ray Washburn | Third | 3 out |
| Thursday, May 30 |
| » Defeated Astros (19-29), 9-5 | Sportsman's Park III (13-9) | 28-21 | Won 3 |
| » Starters: Turk Farrell vs Ray Sadecki | Third | 3 out |
| Friday, May 31 |
| » Defeated Giants (30-18), 6-5 | Sportsman's Park III (14-9) | 29-21 | Won 4 |
| » Starters: Jack Sanford vs Curt Simmons | Second | 2 out |
| Saturday, June 1 |
| » Defeated Giants (30-19), 7-4 | Sportsman's Park III (15-9) | 30-21 | Won 5 |
| » Starters: Jack Fisher vs Ron Taylor | Second | 1 out |
| Sunday, June 2 |
| » Lost to Giants (31-19), 6-4 | Sportsman's Park III (15-10) | 30-22 | |
| » Starters: Juan Marichal vs Ernie Broglio | Second | 2 out |
| Wednesday, June 5 |
| » Lost to Phillies (24-27), 6-0 | Shibe Park (2-3) | 30-23 | Lost 2 |
| » Starters: Curt Simmons vs Ray Culp | Second | 1 out |
| Thursday, June 6 |
| » Defeated Phillies (24-28), 5-4 | Shibe Park (3-3) | 31-23 | |
| » Starters: Bob Gibson vs Chris Short | First | -- |
| Friday, June 7 |
| » Lost to Mets (21-34), 3-2 | Polo Grounds V (2-1) | 31-24 | |
| » Starters: Ron Taylor vs Al Jackson | Second | 1 out |
| Saturday, June 8 |
| » Defeated Mets (21-35), 4-0 | Polo Grounds V (3-1) | 32-24 | |
| » Starters: Ernie Broglio vs Roger Craig | Second | 1 out |
| Former Cardinal Earl Smith dies in Little Rock, AR at the age of 67. |
| Sunday, June 9 |
| » Lost to Mets (22-35), 8-7 | Polo Grounds V (3-2) | 32-25 | |
| » Starters: Curt Simmons vs Carl Willey | Second | 1½ out |
| » Defeated Mets (22-36), 10-4 | Polo Grounds V (4-2) | 33-25 | |
| » Starters: Ray Sadecki vs Jay Hook | Second | 1½ out |
| Tuesday, June 11 |
| » Defeated Pirates (28-29), 3-1 | Forbes Field (3-2) | 34-25 | Won 2 |
| » Starters: Bob Gibson vs Don Schwall | First | -- |
| Wednesday, June 12 |
| » Lost to Phillies (28-30), 6-2 | Sportsman's Park III (15-11) | 34-26 | |
| » Starters: Art Mahaffey vs Ron Taylor | Second | 1 out |
| Thursday, June 13 |
| » Defeated Phillies (28-31), 7-3 | Sportsman's Park III (16-11) | 35-26 | |
| » Starters: Chris Short vs Ernie Broglio | Second | 1 out |
| Friday, June 14 |
| » Defeated Pirates (28-32), 5-2 | Sportsman's Park III (17-11) | 36-26 | Won 2 |
| » Starters: Bob Friend vs Ray Washburn | First | -- |
| Sunday, June 16 |
| » Lost to Pirates (29-32), 4-3 | Sportsman's Park III (17-12) | 36-27 | |
| » Starters: Don Schwall vs Bob Gibson | Second | ½ out |
| » Defeated Pirates (29-33), 11-7 | Sportsman's Park III (18-12) | 37-27 | |
| » Starters: Vern Law vs Curt Simmons | Second | ½ out |
| Monday, June 17 |
| » Defeated Mets (25-41), 8-1 | Sportsman's Park III (19-12) | 38-27 | Won 2 |
| » Starters: Jay Hook vs Ernie Broglio | First | -- |
| Tuesday, June 18 |
| » Defeated Mets (25-42), 6-2 | Sportsman's Park III (20-12) | 39-27 | Won 3 |
| » Starters: Carl Willey vs Lew Burdette | First | -- |
| Wednesday, June 19 |
| » Defeated Mets (25-43), 9-4 | Sportsman's Park III (21-12) | 40-27 | Won 4 |
| » Starters: Tracy Stallard vs Ray Sadecki | First | -- |
| Friday, June 21 |
| » Lost to Dodgers (38-29), 5-3 | Sportsman's Park III (21-13) | 40-28 | |
| » Starters: Sandy Koufax vs Curt Simmons | First | -- |
| Saturday, June 22 |
| » Defeated Dodgers (38-30), 2-1 | Sportsman's Park III (22-13) | 41-28 | |
| » Starters: Nick Willhite vs Bob Gibson | First | -- |
| Sunday, June 23 |
| » Lost to Dodgers (39-30), 4-3 | Sportsman's Park III (22-14) | 41-29 | |
| » Starters: Johnny Podres vs Ernie Broglio | First | -- |
| Monday, June 24 |
| » Lost to Giants (42-30), 4-3 | Sportsman's Park III (22-15) | 41-30 | Lost 2 |
| » Starters: Juan Marichal vs Lew Burdette | Second | ½ out |
| Tuesday, June 25 |
| » Defeated Giants (42-31), 6-5 | Sportsman's Park III (23-15) | 42-30 | |
| » Starters: Jim Duffalo vs Ray Sadecki | First | -- |
| Wednesday, June 26 |
| » Defeated Giants (42-32), 6-5 | Sportsman's Park III (24-15) | 43-30 | Won 2 |
| » Starters: Billy O'Dell vs Curt Simmons | First | -- |
| Friday, June 28 |
| » Defeated Astros (28-48), 9-2 | Colt Stadium (3-0) | 44-30 | Won 3 |
| » Starters: Bob Gibson vs Dick Drott | First | -- |
| Saturday, June 29 |
| » Defeated Astros (28-49), 2-1 | Colt Stadium (4-0) | 45-30 | Won 4 |
| » Starters: Ernie Broglio vs Ken Johnson | First | -- |
| Sunday, June 30 |
| » Lost to Astros (29-49), 1-0 | Colt Stadium (4-1) | 45-31 | |
| » Starters: Lew Burdette vs Hal Brown | First | -- |
| Monday, July 1 |
| » Lost to Astros (30-49), 4-3 | Colt Stadium (4-2) | 45-32 | Lost 2 |
| » Starters: Ray Sadecki vs Bob Bruce | First | -- |
| Tuesday, July 2 |
| » Lost to Dodgers (45-32), 1-0 | Dodger Stadium (3-1) | 45-33 | Lost 3 |
| » Starters: Curt Simmons vs Don Drysdale | Second | ½ out |
| Wednesday, July 3 |
| » Lost to Dodgers (46-32), 5-0 | Dodger Stadium (3-2) | 45-34 | Lost 4 |
| » Starters: Bob Gibson vs Sandy Koufax | Second | 1½ out |
| Thursday, July 4 |
| » Lost to Dodgers (47-32), 10-7 | Dodger Stadium (3-3) | 45-35 | Lost 5 |
| » Starters: Ernie Broglio vs Bob Miller | Second | 2½ out |
| Future Cardinal Jose Oquendo is born in Rio Piedras, P.R. |
| Friday, July 5 |
| » Lost to Giants (46-36), 6-5 | Candlestick Park (1-2) | 45-36 | Lost 6 |
| » Starters: Lew Burdette vs Billy O'Dell | Fourth | 3½ out |
| Saturday, July 6 |
| » Lost to Giants (47-36), 5-3 | Candlestick Park (1-3) | 45-37 | Lost 7 |
| » Starters: Ray Sadecki vs Billy Pierce | Fourth | 3½ out |
| Future Cardinal Lance Johnson is born in Cincinnati, OH. |
| Sunday, July 7 |
| » Lost to Giants (48-36), 4-3 | Candlestick Park (1-4) | 45-38 | Lost 8 |
| » Starters: Curt Simmons vs Jack Sanford | Fourth | 4½ out |
| » Defeated Giants (48-37), 5-0 | Candlestick Park (2-4) | 46-38 | |
| » Starters: Bob Gibson vs Juan Marichal | Fourth | 4½ out |
| » Major-league debuts: Jim Ray Hart (Giants) |
| Thursday, July 11 |
| » Defeated Braves (43-41), 6-3 | Sportsman's Park III (25-15) | 47-38 | Won 2 |
| » Starters: Denny Lemaster vs Ernie Broglio | Third | 5½ out |
| » Lost to Braves (44-41), 5-3 | Sportsman's Park III (25-16) | 47-39 | |
| » Starters: Bob Hendley vs Lew Burdette | Third | 5½ out |
| Friday, July 12 |
| » Defeated Braves (44-42), 5-3 | Sportsman's Park III (26-16) | 48-39 | |
| » Starters: Tony Cloninger vs Bob Gibson | Third | 5½ out |
| Saturday, July 13 |
| » Lost to Braves (45-42), 7-5 | Sportsman's Park III (26-17) | 48-40 | |
| » Starters: Hank Fischer vs Curt Simmons | Fourth | 6½ out |
| Sunday, July 14 |
| » Defeated Cubs (47-40), 10-3 | Sportsman's Park III (27-17) | 49-40 | |
| » Starters: Glen Hobbie vs Ray Sadecki | Fourth | 7 out |
| » Lost to Cubs (48-40), 7-3 | Sportsman's Park III (27-18) | 49-41 | |
| » Starters: Larry Jackson vs Ron Taylor | Fourth | 7 out |
| Monday, July 15 |
| » Lost to Cubs (49-40), 2-0 | Sportsman's Park III (27-19) | 49-42 | Lost 2 |
| » Starters: Dick Ellsworth vs Ernie Broglio | Third | 7 out |
| Tuesday, July 16 |
| » Defeated Reds (49-44), 5-4 | Crosley Field (2-3) | 50-42 | |
| » Starters: Lew Burdette vs Jim Maloney | Third | 6½ out |
| Wednesday, July 17 |
| » Defeated Reds (49-45), 3-1 | Crosley Field (3-3) | 51-42 | Won 2 |
| » Starters: Bob Gibson vs Jim O'Toole | Third | 6½ out |
| Thursday, July 18 |
| » Lost to Reds (50-45), 6-3 | Crosley Field (3-4) | 51-43 | |
| » Starters: Ray Sadecki vs Bob Purkey | Third | 7½ out |
| Friday, July 19 |
| » Defeated Astros (36-62), 7-2 | Sportsman's Park III (28-19) | 52-43 | |
| » Starters: Dick Drott vs Ernie Broglio | Third | 7½ out |
| Future Cardinal Vicente Palacios is born in Veracruz, Mexico. |
| Saturday, July 20 |
| » Defeated Astros (36-63), 8-1 | Sportsman's Park III (29-19) | 53-43 | Won 2 |
| » Starters: Turk Farrell vs Curt Simmons | Second | 7½ out |
| Sunday, July 21 |
| » Defeated Astros (36-64), 9-4 | Sportsman's Park III (30-19) | 54-43 | Won 3 |
| » Starters: Hal Brown vs Bob Gibson | Second | 6 out |
| Tuesday, July 23 |
| » Defeated Braves (49-49), 5-1 | County Stadium (1-3) | 55-43 | Won 4 |
| » Starters: Ray Sadecki vs Bob Hendley | Second | 6 out |
| Wednesday, July 24 |
| » Lost to Braves (50-49), 8-1 | County Stadium (1-4) | 55-44 | |
| » Starters: Ernie Broglio vs Denny Lemaster | Second | 7 out |
| Thursday, July 25 |
| » Defeated Braves (50-50), 3-1 | County Stadium (2-4) | 56-44 | |
| » Starters: Lew Burdette vs Warren Spahn | Second | 6 out |
| Friday, July 26 |
| » Defeated Cubs (53-46), 4-1 | Wrigley Field (3-1) | 57-44 | Won 2 |
| » Starters: Bob Gibson vs Paul Toth | Second | 5 out |
| Saturday, July 27 |
| » Defeated Cubs (53-47), 3-2 | Wrigley Field (4-1) | 58-44 | Won 3 |
| » Starters: Curt Simmons vs Larry Jackson | Second | 4 out |
| Sunday, July 28 |
| » Lost to Cubs (54-47), 5-1 | Wrigley Field (4-2) | 58-45 | |
| » Starters: Ray Sadecki vs Dick Ellsworth | Second | 4½ out |
| » Lost to Cubs (55-47), 16-11 | Wrigley Field (4-3) | 58-46 | Lost 2 |
| » Starters: Ernie Broglio vs Glen Hobbie | Second | 4½ out |
| Tuesday, July 30 |
| » Defeated Reds (56-51), 7-5 | Sportsman's Park III (31-19) | 59-46 | |
| » Starters: Joe Nuxhall vs Lew Burdette | Third | 4 out |
| Wednesday, July 31 |
| » Lost to Reds (57-51), 9-2 | Sportsman's Park III (31-20) | 59-47 | |
| » Starters: Jim O'Toole vs Bob Gibson | Third | 5 out |
| Thursday, August 1 |
| » Defeated Reds (57-52), 3-2 | Sportsman's Park III (32-20) | 60-47 | |
| » Starters: Joey Jay vs Curt Simmons | Second | 4½ out |
| Friday, August 2 |
| » Defeated Phillies (56-52), 3-2 | Sportsman's Park III (33-20) | 61-47 | Won 2 |
| » Starters: Dennis Bennett vs Ray Sadecki | Second | 3½ out |
| Former Cardinal Pete Standridge dies in San Francisco, CA at the age of 73. |
| Saturday, August 3 |
| » Defeated Phillies (56-53), 7-0 | Sportsman's Park III (34-20) | 62-47 | Won 3 |
| » Starters: Cal McLish vs Ernie Broglio | Second | 3½ out |
| Sunday, August 4 |
| » Lost to Phillies (57-53), 7-3 | Sportsman's Park III (34-21) | 62-48 | |
| » Starters: Ray Culp vs Lew Burdette | Third | 5 out |
| » Lost to Phillies (58-53), 5-2 | Sportsman's Park III (34-22) | 62-49 | Lost 2 |
| » Starters: Chris Short vs Bob Gibson | Third | 5 out |
| Former Cardinal Bob Fisher dies in Jacksonville, FL at the age of 77. |
| Tuesday, August 6 |
| » Defeated Mets (34-77), 4-3 | Polo Grounds V (5-2) | 63-49 | |
| » Starters: Curt Simmons vs Galen Cisco | Second | 5 out |
| Wednesday, August 7 |
| » Lost to Mets (35-77), 7-3 | Polo Grounds V (5-3) | 63-50 | |
| » Starters: Ernie Broglio vs Tracy Stallard | Second | 6 out |
| Thursday, August 8 |
| » Lost to Mets (36-77), 3-2 | Polo Grounds V (5-4) | 63-51 | Lost 2 |
| » Starters: Ray Sadecki vs Al Jackson | Third | 6 out |
| Friday, August 9 |
| » Lost to Braves (58-58), 6-3 | County Stadium (2-5) | 63-52 | Lost 3 |
| » Starters: Bob Gibson vs Bob Hendley | Third | 6 out |
| Saturday, August 10 |
| » Defeated Braves (58-59), 6-5 | County Stadium (3-5) | 64-52 | |
| » Starters: Lew Burdette vs Denny Lemaster | Third | 6 out |
| Sunday, August 11 |
| » Lost to Braves (59-59), 9-1 | County Stadium (3-6) | 64-53 | |
| » Starters: Curt Simmons vs Tony Cloninger | Third | 6 out |
| Tuesday, August 13 |
| » Defeated Astros (45-75), 4-2 | Sportsman's Park III (35-22) | 65-53 | |
| » Starters: Bob Bruce vs Ernie Broglio | Third | 5 out |
| Wednesday, August 14 |
| » Defeated Astros (45-76), 3-2 | Sportsman's Park III (36-22) | 66-53 | Won 2 |
| » Starters: Ken Johnson vs Bob Gibson | Third | 4 out |
| Thursday, August 15 |
| » Lost to Astros (46-76), 4-2 | Sportsman's Park III (36-23) | 66-54 | |
| » Starters: Don Nottebart vs Ray Sadecki | Third | 5 out |
| Friday, August 16 |
| » Defeated Giants (68-53), 13-0 | Sportsman's Park III (37-23) | 67-54 | |
| » Starters: Jim Duffalo vs Curt Simmons | Third | 5 out |
| Saturday, August 17 |
| » Defeated Giants (68-54), 8-7 | Sportsman's Park III (38-23) | 68-54 | Won 2 |
| » Starters: Juan Marichal vs Ernie Broglio | Second | 5 out |
| Monday, August 19 |
| » Defeated Giants (68-55), 8-7 | Sportsman's Park III (39-23) | 69-54 | Won 3 |
| » Starters: Jack Sanford vs Bob Gibson | Second | 5½ out |
| Tuesday, August 20 |
| » Lost to Dodgers (75-48), 7-5 | Dodger Stadium (3-4) | 69-55 | |
| » Starters: Lew Burdette vs Johnny Podres | Second | 6½ out |
| Wednesday, August 21 |
| » Lost to Dodgers (76-48), 2-1 | Dodger Stadium (3-5) | 69-56 | Lost 2 |
| » Starters: Curt Simmons vs Sandy Koufax | Second | 7½ out |
| Thursday, August 22 |
| » Defeated Dodgers (76-49), 3-2 | Dodger Stadium (4-5) | 70-56 | |
| » Starters: Ernie Broglio vs Don Drysdale | Second | 6½ out |
| Friday, August 23 |
| » Defeated Astros (47-81), 4-1 | Colt Stadium (5-2) | 71-56 | Won 2 |
| » Starters: Bob Gibson vs Turk Farrell | Second | 5½ out |
| Saturday, August 24 |
| » Lost to Astros (48-81), 4-0 | Colt Stadium (5-3) | 71-57 | |
| » Starters: Ron Taylor vs Hal Brown | Second | 5½ out |
| Sunday, August 25 |
| » Lost to Astros (49-81), 3-1 | Colt Stadium (5-4) | 71-58 | Lost 2 |
| » Starters: Lew Burdette vs Chris Zachary | Second | 6½ out |
| Monday, August 26 |
| » Defeated Giants (71-59), 6-3 | Candlestick Park (3-4) | 72-58 | |
| » Starters: Ernie Broglio vs Juan Marichal | Second | 5½ out |
| Tuesday, August 27 |
| » Lost to Giants (72-59), 7-2 | Candlestick Park (3-5) | 72-59 | |
| » Starters: Curt Simmons vs Jack Sanford | Second | 6½ out |
| Wednesday, August 28 |
| » Lost to Giants (73-59), 5-3 | Candlestick Park (3-6) | 72-60 | Lost 2 |
| » Starters: Bob Gibson vs Billy O'Dell | Third | 6½ out |
| Friday, August 30 |
| » Defeated Phillies (72-63), 11-6 | Shibe Park (4-3) | 73-60 | |
| » Starters: Ray Sadecki vs Ray Culp | Second | 7 out |
| Saturday, August 31 |
| » Defeated Phillies (72-64), 7-5 | Shibe Park (5-3) | 74-60 | Won 2 |
| » Starters: Ernie Broglio vs Dennis Bennett | Second | 6 out |
| Sunday, September 1 |
| » Defeated Phillies (72-65), 7-3 | Shibe Park (6-3) | 75-60 | Won 3 |
| » Starters: Curt Simmons vs Chris Short | Second | 6 out |
| Monday, September 2 |
| » Defeated Pirates (68-67), 6-1 | Sportsman's Park III (40-23) | 76-60 | Won 4 |
| » Starters: Bob Veale vs Bob Gibson | Second | 6 out |
| » Defeated Pirates (68-68), 6-2 | Sportsman's Park III (41-23) | 77-60 | Won 5 |
| » Starters: Joe Gibbon vs Ron Taylor | Second | 6 out |
| Tuesday, September 3 |
| » Defeated Pirates (68-69), 10-5 | Sportsman's Park III (42-23) | 78-60 | Won 6 |
| » Starters: Tommie Sisk vs Ray Sadecki | Second | 6 out |
| Wednesday, September 4 |
| » Defeated Mets (44-95), 6-5 | Sportsman's Park III (43-23) | 79-60 | Won 7 |
| » Starters: Carl Willey vs Ernie Broglio | Second | 5 out |
| Thursday, September 5 |
| » Defeated Mets (44-96), 9-0 | Sportsman's Park III (44-23) | 80-60 | Won 8 |
| » Starters: Grover Powell vs Curt Simmons | Second | 5 out |
| Future Cardinal Jeff Brantley is born in Florence, AL. |
| Friday, September 6 |
| » Defeated Pirates (68-72), 5-1 | Forbes Field (4-2) | 81-60 | Won 9 |
| » Starters: Bob Gibson vs Don Cardwell | Second | 5½ out |
| » Lost to Pirates (69-72), 5-0 | Forbes Field (4-3) | 81-61 | |
| » Starters: Ron Taylor vs Bob Veale | Second | 5½ out |
| Saturday, September 7 |
| » Defeated Pirates (69-73), 6-5 | Forbes Field (5-3) | 82-61 | |
| » Starters: Ray Sadecki vs Joe Gibbon | Second | 4½ out |
| Sunday, September 8 |
| » Defeated Pirates (69-74), 3-2 | Forbes Field (6-3) | 83-61 | Won 2 |
| » Starters: Ernie Broglio vs Bob Friend | Second | 3½ out |
| Monday, September 9 |
| » Defeated Cubs (74-70), 6-0 | Sportsman's Park III (45-23) | 84-61 | Won 3 |
| » Starters: Cal Koonce vs Curt Simmons | Second | 3 out |
| » Major-league debuts: Billy Cowan (Cubs) |
| Tuesday, September 10 |
| » Defeated Cubs (74-71), 8-0 | Sportsman's Park III (46-23) | 85-61 | Won 4 |
| » Starters: Glen Hobbie vs Bob Gibson | Second | 3 out |
| Wednesday, September 11 |
| » Defeated Cubs (74-72), 4-0 | Sportsman's Park III (47-23) | 86-61 | Won 5 |
| » Starters: Dick Ellsworth vs Ray Sadecki | Second | 3 out |
| Former Cardinal Ham Hyatt dies in Liberty Lake, WA at the age of 79. |
| Thursday, September 12 |
| » Defeated Cubs (74-73), 8-3 | Sportsman's Park III (48-23) | 87-61 | Won 6 |
| » Starters: Larry Jackson vs Ernie Broglio | Second | 3 out |
| Friday, September 13 |
| » Defeated Braves (80-68), 7-0 | Sportsman's Park III (49-23) | 88-61 | Won 7 |
| » Starters: Warren Spahn vs Curt Simmons | Second | 2½ out |
| Saturday, September 14 |
| » Defeated Braves (80-69), 3-2 | Sportsman's Park III (50-23) | 89-61 | Won 8 |
| » Starters: Bob Sadowski vs Bob Gibson | Second | 2½ out |
| Sunday, September 15 |
| » Defeated Braves (80-70), 3-2 | Sportsman's Park III (51-23) | 90-61 | Won 9 |
| » Starters: Bob Hendley vs Lew Burdette | Second | 1 out |
| » Defeated Braves (80-71), 5-0 | Sportsman's Park III (52-23) | 91-61 | Won 10 |
| » Starters: Denny Lemaster vs Ray Sadecki | Second | 1 out |
| » Major-league debuts: Rico Carty (Braves) |
| Monday, September 16 |
| » Lost to Dodgers (92-59), 3-1 | Sportsman's Park III (52-24) | 91-62 | |
| » Starters: Johnny Podres vs Ernie Broglio | Second | 2 out |
| Tuesday, September 17 |
| » Lost to Dodgers (93-59), 4-0 | Sportsman's Park III (52-25) | 91-63 | Lost 2 |
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