| Sunday, February 10 |
| Future Athletic Dane Johnson is born in Coral Gables, FL. |
| Monday, April 8 |
| » Major-league debuts: Tom Brown (Senators) |
| Tuesday, April 9 |
| » Lost to Yankees (1-0), 8-2 | Municipal Stadium (0-1) | 0-1 | |
| » Starters: Ralph Terry vs Diego Segui | Second | 1 out |
| Future Athletic Mike Brumley is born in Oklahoma City, OK. |
| Wednesday, April 10 |
| » Lost to Yankees (2-0), 5-3 | Municipal Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Bill Stafford vs Ted Bowsfield | Third | 2 out |
| Friday, April 12 |
| » Defeated Twins (1-2), 6-0 | Municipal Stadium (1-2) | 1-2 | |
| » Starters: Jack Kralick vs Ed Rakow | Third | 2 out |
| » Major-league debuts: Fred Lasher (Twins) |
| Saturday, April 13 |
| » Defeated Twins (1-3), 3-2 | Municipal Stadium (2-2) | 2-2 | Won 2 |
| » Starters: Dick Stigman vs Dave Wickersham | Second | 1 out |
| Sunday, April 14 |
| » Defeated Twins (1-4), 5-4 | Municipal Stadium (3-2) | 3-2 | Won 3 |
| » Starters: Camilo Pascual vs Diego Segui | Second | 1 out |
| » Major-league debuts: Paul Ratliff (Twins) |
| Tuesday, April 16 |
| » Defeated White Sox (2-3), 7-4 | Comiskey Park I (1-0) | 4-2 | Won 4 |
| » Starters: Ted Bowsfield vs Eddie Fisher | First | -- |
| Thursday, April 18 |
| » Lost to White Sox (3-3), 3-0 | Comiskey Park I (1-1) | 4-3 | |
| » Starters: Ed Rakow vs Ray Herbert | Second | 1 out |
| Friday, April 19 |
| » Defeated Angels (3-5), 3-2 | Municipal Stadium (4-2) | 5-3 | |
| » Starters: Bo Belinsky vs Orlando Pena | First | -- |
| » Defeated Angels (3-6), 3-2 | Municipal Stadium (5-2) | 6-3 | Won 2 |
| » Starters: Bob Turley vs Dave Wickersham | First | -- |
| Saturday, April 20 |
| » Lost to Angels (4-6), 7-4 | Municipal Stadium (5-3) | 6-4 | |
| » Starters: Dean Chance vs Diego Segui | Third | ½ out |
| » Major-league debuts: Dave Thies (Athletics) |
| Sunday, April 21 |
| » Lost to Angels (5-6), 6-2 | Municipal Stadium (5-4) | 6-5 | Lost 2 |
| » Starters: Don Lee vs Ted Bowsfield | Third | 1 out |
| Monday, April 22 |
| » Defeated Tigers (6-6), 6-5 | Municipal Stadium (6-4) | 7-5 | |
| » Starters: Don Mossi vs Norm Bass | Third | ½ out |
| Tuesday, April 23 |
| » Defeated Tigers (6-7), 3-1 | Municipal Stadium (7-4) | 8-5 | Won 2 |
| » Starters: Phil Regan vs Ed Rakow | Second | ½ out |
| Wednesday, April 24 |
| » Defeated Orioles (8-5), 5-0 | Memorial Stadium (1-0) | 9-5 | Won 3 |
| » Starters: Orlando Pena vs Mike McCormick | First | -- |
| Thursday, April 25 |
| » Lost to Orioles (9-5), 3-2 | Memorial Stadium (1-1) | 9-6 | |
| » Starters: Dave Wickersham vs Steve Barber | Third | ½ out |
| Friday, April 26 |
| » Defeated Senators (4-10), 12-10 | Robert F. Kennedy Stadium (1-0) | 10-6 | |
| » Starters: Diego Segui vs Claude Osteen | Third | 3 out |
| » Lost to Senators (5-10), 6-0 | Robert F. Kennedy Stadium (1-1) | 10-7 | |
| » Starters: Ted Bowsfield vs Tom Cheney | Third | 3 out |
| Saturday, April 27 |
| » Defeated Senators (5-11), 7-3 | Robert F. Kennedy Stadium (2-1) | 11-7 | |
| » Starters: Dan Pfister vs Ron Kline | Second | 1 out |
| Sunday, April 28 |
| » Defeated Senators (5-12), 6-5 | Robert F. Kennedy Stadium (3-1) | 12-7 | Won 2 |
| » Starters: Ed Rakow vs Jim Coates | First | -- |
| Wednesday, May 1 |
| » Defeated Indians (5-9), 11-3 | Municipal Stadium (8-4) | 13-7 | Won 3 |
| » Starters: Gary Bell vs Orlando Pena | First | -- |
| Thursday, May 2 |
| » Lost to Indians (6-9), 15-6 | Municipal Stadium (8-5) | 13-8 | |
| » Starters: Pedro Ramos vs Dave Wickersham | Second | 2½ out |
| Friday, May 3 |
| » Defeated Red Sox (10-7), 3-1 | Municipal Stadium (9-5) | 14-8 | |
| » Starters: Bill Monbouquette vs Ed Rakow | First | -- |
| Saturday, May 4 |
| » Defeated Red Sox (10-8), 14-3 | Municipal Stadium (10-5) | 15-8 | Won 2 |
| » Starters: Ike Delock vs Dave Thies | First | -- |
| » Major-league debuts: Jim Gosger (Red Sox) |
| Sunday, May 5 |
| » Lost to Red Sox (11-8), 3-2 | Municipal Stadium (10-6) | 15-9 | |
| » Starters: Dave Morehead vs Orlando Pena | First | -- |
| Monday, May 6 |
| » Lost to White Sox (12-10), 5-1 | Municipal Stadium (10-7) | 15-10 | Lost 2 |
| » Starters: Gary Peters vs Ted Bowsfield | First | -- |
| Tuesday, May 7 |
| » Lost to White Sox (13-10), 2-1 | Municipal Stadium (10-8) | 15-11 | Lost 3 |
| » Starters: John Buzhardt vs Dave Wickersham | Second | 3 out |
| Wednesday, May 8 |
| » Lost to White Sox (14-10), 8-3 | Municipal Stadium (10-9) | 15-12 | Lost 4 |
| » Starters: Eddie Fisher vs Ed Rakow | Third | 1½ out |
| Friday, May 10 |
| » Lost to Twins (11-16), 2-0 | Metropolitan Stadium (0-1) | 15-13 | Lost 5 |
| » Starters: Orlando Pena vs Camilo Pascual | Fourth | 2 out |
| » Major-league debuts: Tony LaRussa (Athletics) |
| Saturday, May 11 |
| » Defeated Twins (11-17), 5-1 | Metropolitan Stadium (1-1) | 16-13 | |
| » Starters: Ted Bowsfield vs Jim Roland | Third | 2 out |
| Sunday, May 12 |
| » Defeated Twins (11-18), 2-1 | Metropolitan Stadium (2-1) | 17-13 | Won 2 |
| » Starters: Dave Wickersham vs Jim Perry | Second | 1½ out |
| Tuesday, May 14 |
| » Defeated Indians (12-13), 5-2 | Cleveland Stadium (1-0) | 18-13 | Won 3 |
| » Starters: Ed Rakow vs Jack Kralick | Second | 1 out |
| Wednesday, May 15 |
| » Lost to Indians (13-13), 1-0 | Cleveland Stadium (1-1) | 18-14 | |
| » Starters: Orlando Pena vs Mudcat Grant | Fourth | 2 out |
| Friday, May 17 |
| » Defeated Red Sox (18-12), 2-0 | Fenway Park (1-0) | 19-14 | |
| » Starters: Ted Bowsfield vs Dave Morehead | Fourth | 1 out |
| Sunday, May 19 |
| » Lost to Red Sox (19-12), 7-3 | Fenway Park (1-1) | 19-15 | |
| » Starters: Dave Wickersham vs Bill Monbouquette | Fourth | 1½ out |
| » Defeated Red Sox (19-13), 9-7 | Fenway Park (2-1) | 20-15 | |
| » Starters: Ed Rakow vs Gene Conley | Fourth | 1½ out |
| Tuesday, May 21 |
| » Lost to Yankees (19-13), 7-4 | Yankee Stadium (0-1) | 20-16 | |
| » Starters: Orlando Pena vs Jim Bouton | Fourth | 2 out |
| Wednesday, May 22 |
| » Lost to Yankees (20-13), 8-7 | Yankee Stadium (0-2) | 20-17 | Lost 2 |
| » Starters: Ted Bowsfield vs Bill Stafford | Fourth | 3 out |
| Friday, May 24 |
| » Defeated Angels (19-24), 3-1 | Dodger Stadium (1-0) | 21-17 | |
| » Starters: Dave Wickersham vs Ken McBride | Fifth | 3½ out |
| Saturday, May 25 |
| » Defeated Angels (19-25), 9-2 | Dodger Stadium (2-0) | 22-17 | Won 2 |
| » Starters: Ed Rakow vs Mel Nelson | Fourth | 3½ out |
| Sunday, May 26 |
| » Lost to Angels (20-25), 6-4 | Dodger Stadium (2-1) | 22-18 | |
| » Starters: Orlando Pena vs Dan Osinski | Fourth | 5 out |
| » Major-league debuts: Charlie Dees (Angels) |
| Monday, May 27 |
| Future Athletic Edwin Nunez is born in Humacao, P.R. |
| Tuesday, May 28 |
| » Lost to Orioles (30-15), 4-2 | Municipal Stadium (10-10) | 22-19 | Lost 2 |
| » Starters: Robin Roberts vs Ted Bowsfield | Fifth | 6 out |
| Wednesday, May 29 |
| » Defeated Orioles (30-16), 5-4 | Municipal Stadium (11-10) | 23-19 | |
| » Starters: Mike McCormick vs Dave Wickersham | Fifth | 5 out |
| Thursday, May 30 |
| » Defeated Orioles (30-17), 7-2 | Municipal Stadium (12-10) | 24-19 | Won 2 |
| » Starters: Steve Barber vs Ed Rakow | Fourth | 4 out |
| Friday, May 31 |
| » Defeated Senators (15-35), 9-3 | Municipal Stadium (13-10) | 25-19 | Won 3 |
| » Starters: Don Rudolph vs Orlando Pena | Fourth | 3 out |
| Saturday, June 1 |
| » Lost to Senators (16-35), 9-1 | Municipal Stadium (13-11) | 25-20 | |
| » Starters: Jim Duckworth vs Dave Thies | Fourth | 3 out |
| Sunday, June 2 |
| » Lost to Senators (17-35), 6-4 | Municipal Stadium (13-12) | 25-21 | Lost 2 |
| » Starters: Bennie Daniels vs Ted Bowsfield | Fourth | 2½ out |
| Monday, June 3 |
| » Defeated Twins (24-24), 4-1 | Municipal Stadium (14-12) | 26-21 | |
| » Starters: Camilo Pascual vs Dave Wickersham | Third | 2 out |
| Tuesday, June 4 |
| » Lost to Twins (25-24), 5-0 | Municipal Stadium (14-13) | 26-22 | |
| » Starters: Jim Perry vs Ed Rakow | Fourth | 3½ out |
| Wednesday, June 5 |
| » Lost to Twins (26-24), 4-0 | Municipal Stadium (14-14) | 26-23 | Lost 2 |
| » Starters: Jim Roland vs Orlando Pena | Fourth | 3 out |
| Friday, June 7 |
| » Lost to White Sox (32-22), 7-1 | Municipal Stadium (14-15) | 26-24 | Lost 3 |
| » Starters: Juan Pizarro vs Dave Wickersham | Fifth | 4½ out |
| Saturday, June 8 |
| » Defeated White Sox (32-23), 7-6 | Municipal Stadium (15-15) | 27-24 | |
| » Starters: Eddie Fisher vs Ted Bowsfield | Fifth | 3½ out |
| Sunday, June 9 |
| » Lost to White Sox (33-23), 4-3 | Municipal Stadium (15-16) | 27-25 | |
| » Starters: Gary Peters vs Ed Rakow | Fifth | 4 out |
| Monday, June 10 |
| » Lost to Angels (28-31), 13-3 | Municipal Stadium (15-17) | 27-26 | Lost 2 |
| » Starters: Dan Osinski vs Orlando Pena | Fifth | 4½ out |
| Tuesday, June 11 |
| » Defeated Angels (28-32), 5-2 | Municipal Stadium (16-17) | 28-26 | |
| » Starters: Dean Chance vs Diego Segui | Fifth | 3½ out |
| Wednesday, June 12 |
| » Defeated Twins (29-26), 12-4 | Metropolitan Stadium (3-1) | 29-26 | Won 2 |
| » Starters: Dave Wickersham vs Jim Kaat | Sixth | 3 out |
| » Lost to Twins (30-26), 8-1 | Metropolitan Stadium (3-2) | 29-27 | |
| » Starters: Orlando Pena vs Camilo Pascual | Sixth | 3 out |
| Thursday, June 13 |
| » Lost to Twins (31-26), 6-3 | Metropolitan Stadium (3-3) | 29-28 | Lost 2 |
| » Starters: Moe Drabowsky vs Jim Perry | Sixth | 4 out |
| Friday, June 14 |
| » Lost to White Sox (35-25), 3-2 | Comiskey Park I (1-2) | 29-29 | Lost 3 |
| » Starters: Ed Rakow vs Gary Peters | Seventh | 5 out |
| Saturday, June 15 |
| » Defeated White Sox (35-26), 4-3 | Comiskey Park I (2-2) | 30-29 | |
| » Starters: Diego Segui vs Ray Herbert | Seventh | 4 out |
| Sunday, June 16 |
| » Lost to White Sox (36-26), 2-1 | Comiskey Park I (2-3) | 30-30 | |
| » Starters: Dave Wickersham vs John Buzhardt | Seventh | 6 out |
| » Lost to White Sox (37-26), 3-2 | Comiskey Park I (2-4) | 30-31 | Lost 2 |
| » Starters: Orlando Pena vs Juan Pizarro | Seventh | 6 out |
| Tuesday, June 18 |
| » Lost to Angels (33-34), 2-1 | Dodger Stadium (2-2) | 30-32 | Lost 3 |
| » Starters: Moe Drabowsky vs Ken McBride | Eighth | 7 out |
| Wednesday, June 19 |
| » Lost to Angels (34-34), 4-2 | Dodger Stadium (2-3) | 30-33 | Lost 4 |
| » Starters: Ed Rakow vs Dan Osinski | Eighth | 7½ out |
| » Defeated Angels (34-35), 4-3 | Dodger Stadium (3-3) | 31-33 | |
| » Starters: Diego Segui vs Don Lee | Eighth | 7½ out |
| Friday, June 21 |
| » Lost to Tigers (25-39), 6-4 | Municipal Stadium (16-18) | 31-34 | |
| » Starters: Hank Aguirre vs Dave Wickersham | Eighth | 8 out |
| Saturday, June 22 |
| » Lost to Tigers (26-39), 3-2 | Municipal Stadium (16-19) | 31-35 | Lost 2 |
| » Starters: Phil Regan vs Orlando Pena | Eighth | 9½ out |
| Sunday, June 23 |
| » Lost to Tigers (27-39), 11-2 | Municipal Stadium (16-20) | 31-36 | Lost 3 |
| » Starters: Mickey Lolich vs Moe Drabowsky | Eighth | 10½ out |
| Monday, June 24 |
| » Defeated Tigers (27-40), 6-3 | Municipal Stadium (17-20) | 32-36 | |
| » Starters: Don Mossi vs Ed Rakow | Eighth | 9½ out |
| Tuesday, June 25 |
| » Defeated Senators (22-53), 8-4 | Municipal Stadium (18-20) | 33-36 | Won 2 |
| » Starters: Dave Stenhouse vs Diego Segui | Eighth | 8½ out |
| Future Athletic Mike Stanley is born in Fort Lauderdale, FL. |
| Thursday, June 27 |
| » Lost to Senators (23-53), 4-2 | Municipal Stadium (18-21) | 33-37 | |
| » Starters: Bennie Daniels vs Dave Wickersham | Eighth | 9 out |
| Friday, June 28 |
| » Lost to Orioles (39-37), 2-1 | Memorial Stadium (1-2) | 33-38 | Lost 2 |
| » Starters: Orlando Pena vs Steve Barber | Eighth | 9 out |
| Saturday, June 29 |
| » Lost to Orioles (40-37), 3-2 | Memorial Stadium (1-3) | 33-39 | Lost 3 |
| » Starters: Moe Drabowsky vs Milt Pappas | Eighth | 10 out |
| Sunday, June 30 |
| » Defeated Orioles (40-38), 3-1 | Memorial Stadium (2-3) | 34-39 | |
| » Starters: Ed Rakow vs Robin Roberts | Eighth | 11 out |
| » Lost to Orioles (41-38), 4-3 | Memorial Stadium (2-4) | 34-40 | |
| » Starters: Diego Segui vs Mike McCormick | Eighth | 11 out |
| Monday, July 1 |
| » Defeated Orioles (41-39), 6-4 | Memorial Stadium (3-4) | 35-40 | |
| » Starters: Dave Wickersham vs Dave McNally | Seventh | 11 out |
| Tuesday, July 2 |
| » Lost to Senators (24-56), 7-2 | Robert F. Kennedy Stadium (3-2) | 35-41 | |
| » Starters: Orlando Pena vs Bennie Daniels | Eighth | 12 out |
| Thursday, July 4 |
| » Lost to Senators (25-56), 2-1 | Robert F. Kennedy Stadium (3-3) | 35-42 | Lost 2 |
| » Starters: Moe Drabowsky vs Tom Cheney | Eighth | 13½ out |
| » Lost to Senators (26-56), 3-2 | Robert F. Kennedy Stadium (3-4) | 35-43 | Lost 3 |
| » Starters: Diego Segui vs Claude Osteen | Eighth | 13½ out |
| Friday, July 5 |
| » Lost to Tigers (33-46), 4-3 | Tiger Stadium (0-1) | 35-44 | Lost 4 |
| » Starters: Dave Wickersham vs Mickey Lolich | Eighth | 13½ out |
| Saturday, July 6 |
| » Lost to Tigers (34-46), 8-4 | Tiger Stadium (0-2) | 35-45 | Lost 5 |
| » Starters: Ed Rakow vs Bill Faul | Eighth | 14½ out |
| Sunday, July 7 |
| » Lost to Tigers (35-46), 5-1 | Tiger Stadium (0-3) | 35-46 | Lost 6 |
| » Starters: Orlando Pena vs Jim Bunning | Eighth | 14½ out |
| » Defeated Tigers (35-47), 8-7 | Tiger Stadium (1-3) | 36-46 | |
| » Starters: Bill Fischer vs Frank Lary | Eighth | 14½ out |
| Thursday, July 11 |
| » Lost to Indians (45-40), 8-6 | Municipal Stadium (18-22) | 36-47 | |
| » Starters: Dick Donovan vs Dave Wickersham | Seventh | 15½ out |
| Saturday, July 13 |
| » Defeated Indians (45-41), 6-5 | Municipal Stadium (19-22) | 37-47 | |
| » Starters: Jack Kralick vs Diego Segui | Seventh | 15½ out |
| » Lost to Indians (46-41), 7-4 | Municipal Stadium (19-23) | 37-48 | |
| » Starters: Early Wynn vs Moe Drabowsky | Seventh | 15½ out |
| Sunday, July 14 |
| » Lost to Yankees (53-32), 11-6 | Municipal Stadium (19-24) | 37-49 | Lost 2 |
| » Starters: Bill Stafford vs Ed Rakow | Ninth | 17½ out |
| » Lost to Yankees (54-32), 5-0 | Municipal Stadium (19-25) | 37-50 | Lost 3 |
| » Starters: Al Downing vs Orlando Pena | Ninth | 17½ out |
| Monday, July 15 |
| » Defeated Yankees (54-33), 11-10 | Municipal Stadium (20-25) | 38-50 | |
| » Starters: Whitey Ford vs Dave Wickersham | Eighth | 16½ out |
| Tuesday, July 16 |
| » Defeated Red Sox (49-40), 11-0 | Municipal Stadium (21-25) | 39-50 | Won 2 |
| » Starters: Dave Morehead vs Moe Drabowsky | Eighth | 16 out |
| Wednesday, July 17 |
| » Defeated Red Sox (49-41), 8-1 | Municipal Stadium (22-25) | 40-50 | Won 3 |
| » Starters: Bob Heffner vs Diego Segui | Eighth | 16 out |
| Thursday, July 18 |
| » Lost to Red Sox (50-41), 10-6 | Municipal Stadium (22-26) | 40-51 | |
| » Starters: Chet Nichols vs Ed Rakow | Eighth | 16 out |
| Friday, July 19 |
| » Defeated Orioles (52-45), 2-1 | Municipal Stadium (23-26) | 41-51 | |
| » Starters: Dave McNally vs Orlando Pena | Eighth | 15½ out |
| Saturday, July 20 |
| » Lost to Orioles (53-45), 6-3 | Municipal Stadium (23-27) | 41-52 | |
| » Starters: Robin Roberts vs Dave Wickersham | Eighth | 16½ out |
| Sunday, July 21 |
| » Defeated Orioles (53-46), 3-2 | Municipal Stadium (24-27) | 42-52 | |
| » Starters: Milt Pappas vs Moe Drabowsky | Eighth | 17 out |
| Tuesday, July 23 |
| » Defeated Red Sox (51-43), 1-0 | Fenway Park (3-1) | 43-52 | Won 2 |
| » Starters: Diego Segui vs Bob Heffner | Seventh | 17½ out |
| Wednesday, July 24 |
| » Defeated Red Sox (51-44), 5-2 | Fenway Park (4-1) | 44-52 | Won 3 |
| » Starters: Orlando Pena vs Earl Wilson | Seventh | 17 out |
| » Defeated Red Sox (51-45), 7-6 | Fenway Park (5-1) | 45-52 | Won 4 |
| » Starters: Dave Wickersham vs Dave Morehead | Seventh | 17 out |
| Thursday, July 25 |
| » Defeated Red Sox (51-46), 2-0 | Fenway Park (6-1) | 46-52 | Won 5 |
| » Starters: Ed Rakow vs Bill Monbouquette | Seventh | 16 out |
| Friday, July 26 |
| » Lost to Indians (49-52), 3-2 | Cleveland Stadium (1-2) | 46-53 | |
| » Starters: Moe Drabowsky vs Jack Kralick | Seventh | 17 out |
| Saturday, July 27 |
| » Lost to Indians (50-52), 3-2 | Cleveland Stadium (1-3) | 46-54 | Lost 2 |
| » Starters: Diego Segui vs Early Wynn | Eighth | 18 out |
| Sunday, July 28 |
| » Defeated Indians (50-53), 3-0 | Cleveland Stadium (2-3) | 47-54 | |
| » Starters: Orlando Pena vs Jerry Walker | Eighth | 18 out |
| » Lost to Indians (51-53), 12-7 | Cleveland Stadium (2-4) | 47-55 | |
| » Starters: Bill Fischer vs Mudcat Grant | Eighth | 18 out |
| Monday, July 29 |
| » Defeated Yankees (64-37), 5-0 | Yankee Stadium (1-2) | 48-55 | |
| » Starters: Dave Wickersham vs Al Downing | Eighth | 17 out |
| Tuesday, July 30 |
| » Lost to Yankees (65-37), 6-2 | Yankee Stadium (1-3) | 48-56 | |
| » Starters: Moe Drabowsky vs Jim Bouton | Eighth | 18 out |
| Wednesday, July 31 |
| » Lost to Yankees (66-37), 3-2 | Yankee Stadium (1-4) | 48-57 | Lost 2 |
| » Starters: Diego Segui vs Ralph Terry | Eighth | 19 out |
| Friday, August 2 |
| » Lost to Twins (58-49), 10-3 | Municipal Stadium (24-28) | 48-58 | Lost 3 |
| » Starters: Camilo Pascual vs Orlando Pena | Eighth | 19 out |
| Saturday, August 3 |
| » Lost to Twins (59-49), 7-2 | Municipal Stadium (24-29) | 48-59 | Lost 4 |
| » Starters: Dick Stigman vs Dave Wickersham | Eighth | 20 out |
| Sunday, August 4 |
| » Defeated Twins (59-50), 6-2 | Municipal Stadium (25-29) | 49-59 | |
| » Starters: Jim Perry vs Moe Drabowsky | Eighth | 19½ out |
| Tuesday, August 6 |
| » Defeated White Sox (61-48), 4-3 | Municipal Stadium (26-29) | 50-59 | Won 2 |
| » Starters: Ray Herbert vs Diego Segui | Eighth | 19 out |
| Wednesday, August 7 |
| » Lost to White Sox (62-48), 7-3 | Municipal Stadium (26-30) | 50-60 | |
| » Starters: Juan Pizarro vs Orlando Pena | Eighth | 20 out |
| Thursday, August 8 |
| » Lost to White Sox (63-48), 5-3 | Municipal Stadium (26-31) | 50-61 | Lost 2 |
| » Starters: Gary Peters vs Dave Wickersham | Ninth | 21 out |
| Friday, August 9 |
| » Defeated Indians (56-60), 5-1 | Cleveland Stadium (3-4) | 51-61 | |
| » Starters: Moe Drabowsky vs Jack Kralick | Eighth | 21 out |
| Saturday, August 10 |
| » Defeated Indians (56-61), 6-3 | Cleveland Stadium (4-4) | 52-61 | Won 2 |
| » Starters: Diego Segui vs Pedro Ramos | Seventh | 21 out |
| Sunday, August 11 |
| » Lost to Indians (57-61), 2-1 | Cleveland Stadium (4-5) | 52-62 | |
| » Starters: Orlando Pena vs Barry Latman | Seventh | 22 out |
| Tuesday, August 13 |
| » Defeated Tigers (51-64), 4-2 | Municipal Stadium (27-31) | 53-62 | |
| » Starters: Jim Bunning vs Dave Wickersham | Seventh | 21½ out |
| Wednesday, August 14 |
| » Lost to Tigers (52-64), 5-2 | Municipal Stadium (27-32) | 53-63 | |
| » Starters: Phil Regan vs Moe Drabowsky | Eighth | 21 out |
| Thursday, August 15 |
| » Lost to Tigers (53-64), 11-1 | Municipal Stadium (27-33) | 53-64 | Lost 2 |
| » Starters: Hank Aguirre vs Diego Segui | Eighth | 22 out |
| Future Athletic Eric Fox is born in Lemoore, CA. |
| Friday, August 16 |
| » Lost to Orioles (67-56), 4-3 | Municipal Stadium (27-34) | 53-65 | Lost 3 |
| » Starters: Dave McNally vs Orlando Pena | Eighth | 23 out |
| Saturday, August 17 |
| » Lost to Orioles (68-56), 6-1 | Municipal Stadium (27-35) | 53-66 | Lost 4 |
| » Starters: Steve Barber vs Ed Rakow | Ninth | 23 out |
| Sunday, August 18 |
| » Defeated Orioles (68-57), 5-4 | Municipal Stadium (28-35) | 54-66 | |
| » Starters: Robin Roberts vs Dave Wickersham | Eighth | 23½ out |
| Tuesday, August 20 |
| » Defeated Senators (45-78), 9-0 | Municipal Stadium (29-35) | 55-66 | Won 2 |
| » Starters: Claude Osteen vs Moe Drabowsky | Eighth | 22 out |
| » Defeated Senators (45-79), 7-5 | Municipal Stadium (30-35) | 56-66 | Won 3 |
| » Starters: Jim Duckworth vs Tom Sturdivant | Eighth | 22 out |
| Wednesday, August 21 |
| » Lost to Senators (46-79), 5-1 | Municipal Stadium (30-36) | 56-67 | |
| » Starters: Ron Moeller vs Orlando Pena | Eighth | 23½ out |
| Thursday, August 22 |
| » Defeated Senators (46-80), 6-2 | Municipal Stadium (31-36) | 57-67 | |
| » Starters: Bennie Daniels vs Ed Rakow | Seventh | 22½ out |
| Friday, August 23 |
| » Lost to Tigers (57-66), 17-2 | Tiger Stadium (1-4) | 57-68 | |
| » Starters: Pete Lovrich vs Frank Lary | Ninth | 24 out |
| » Lost to Tigers (58-66), 6-2 | Tiger Stadium (1-5) | 57-69 | Lost 2 |
| » Starters: Dave Wickersham vs Phil Regan | Ninth | 24 out |
| Saturday, August 24 |
| » Lost to Tigers (59-66), 4-3 | Tiger Stadium (1-6) | 57-70 | Lost 3 |
| » Starters: Moe Drabowsky vs Mickey Lolich | Eighth | 25 out |
| Former Athletic Ren Kelly dies in Millbrae, CA at the age of 64. |
| Sunday, August 25 |
| » Lost to Tigers (60-66), 11-5 | Tiger Stadium (1-7) | 57-71 | Lost 4 |
| » Starters: Tom Sturdivant vs Hank Aguirre | Ninth | 26 out |
| » Lost to Tigers (61-66), 4-3 | Tiger Stadium (1-8) | 57-72 | Lost 5 |
| » Starters: Orlando Pena vs Jim Bunning | Ninth | 26 out |
| Tuesday, August 27 |
| » Defeated Orioles (72-61), 2-1 | Memorial Stadium (4-4) | 58-72 | |
| » Starters: Ed Rakow vs Robin Roberts | Eighth | 26½ out |
| Wednesday, August 28 |
| » Lost to Orioles (73-61), 3-1 | Memorial Stadium (4-5) | 58-73 | |
| » Starters: Dave Wickersham vs Milt Pappas | Ninth | 27½ out |
| Friday, August 30 |
| » Lost to Angels (61-75), 6-2 | Municipal Stadium (31-37) | 58-74 | Lost 2 |
| » Starters: Mike Lee vs Moe Drabowsky | Ninth | 28 out |
| Saturday, August 31 |
| » Defeated Angels (61-76), 7-0 | Municipal Stadium (32-37) | 59-74 | |
| » Starters: Ken McBride vs Orlando Pena | Ninth | 28 out |
| Sunday, September 1 |
| » Defeated Angels (61-77), 7-6 | Municipal Stadium (33-37) | 60-74 | Won 2 |
| » Starters: Dean Chance vs Ed Rakow | Eighth | 28 out |
| Monday, September 2 |
| » Lost to Twins (76-60), 6-2 | Metropolitan Stadium (3-4) | 60-75 | |
| » Starters: Dave Wickersham vs Jim Perry | Ninth | 29 out |
| » Lost to Twins (77-60), 3-1 | Metropolitan Stadium (3-5) | 60-76 | Lost 2 |
| » Starters: Tom Sturdivant vs Lee Stange | Ninth | 29 out |
| Tuesday, September 3 |
| » Defeated Twins (77-61), 3-2 | Metropolitan Stadium (4-5) | 61-76 | |
| » Starters: Moe Drabowsky vs Camilo Pascual | Eighth | 28 out |
| Wednesday, September 4 |
| » Defeated White Sox (78-61), 4-2 | Comiskey Park I (3-4) | 62-76 | Won 2 |
| » Starters: Orlando Pena vs Ray Herbert | Eighth | 27½ out |
| » Defeated White Sox (78-62), 7-3 | Comiskey Park I (4-4) | 63-76 | Won 3 |
| » Starters: Diego Segui vs Joe Horlen | Eighth | 27½ out |
| » Major-league debuts: Bruce Howard (White Sox) |
| Thursday, September 5 |
| » Lost to White Sox (79-62), 4-1 | Comiskey Park I (4-5) | 63-77 | |
| » Starters: Ed Rakow vs Gary Peters | Eighth | 28½ out |
| Friday, September 6 |
| » Lost to Angels (64-79), 4-3 | Dodger Stadium (3-4) | 63-78 | Lost 2 |
| » Starters: Dave Wickersham vs Mike Lee | Ninth | 29½ out |
| Saturday, September 7 |
| » Defeated Angels (64-80), 5-2 | Dodger Stadium (4-4) | 64-78 | |
| » Starters: Moe Drabowsky vs Ken McBride | Eighth | 29½ out |
| Sunday, September 8 |
| » Defeated Angels (64-81), 2-1 | Dodger Stadium (5-4) | 65-78 | Won 2 |
| » Starters: Orlando Pena vs Don Lee | Eighth | 29½ out |
| Monday, September 9 |
| » Defeated Yankees (95-50), 7-6 | Municipal Stadium (34-37) | 66-78 | Won 3 |
| » Starters: Jim Bouton vs Fred Norman | Eighth | 28½ out |
| Tuesday, September 10 |
| » Defeated Yankees (95-51), 2-0 | Municipal Stadium (35-37) | 67-78 | Won 4 |
| » Starters: Ralph Terry vs Diego Segui | Eighth | 27½ out |
| Wednesday, September 11 |
| » Lost to Yankees (96-51), 8-2 | Municipal Stadium (35-38) | 67-79 | |
| » Starters: Whitey Ford vs Ed Rakow | Eighth | 28½ out |
| Thursday, September 12 |
| » Lost to Yankees (97-51), 5-2 | Municipal Stadium (35-39) | 67-80 | Lost 2 |
| » Starters: Stan Williams vs Moe Drabowsky | Eighth | 29½ out |
| Friday, September 13 |
| » Lost to Red Sox (71-79), 7-3 | Municipal Stadium (35-40) | 67-81 | Lost 3 |
| » Starters: Earl Wilson vs Dave Wickersham | Seventh | 30½ out |
| Saturday, September 14 |
| » Lost to Red Sox (72-79), 6-4 | Municipal Stadium (35-41) | 67-82 | Lost 4 |
| » Starters: Bill Monbouquette vs Orlando Pena | Eighth | 31 out |
| Sunday, September 15 |
| » Lost to Red Sox (73-79), 5-3 | Municipal Stadium (35-42) | 67-83 | Lost 5 |
| » Starters: Pete Smith vs Diego Segui | Eighth | 32 out |
| Tuesday, September 17 |
| » Defeated Senators (53-98), 4-3 | Robert F. Kennedy Stadium (4-4) | 68-83 | |
| » Starters: Moe Drabowsky vs Bennie Daniels | Eighth | 31 out |
| Wednesday, September 18 |
| » Defeated Senators (53-99), 5-4 | Robert F. Kennedy Stadium (5-4) | 69-83 | Won 2 |
| » Starters: Dave Wickersham vs Claude Osteen | Eighth | 30½ out |
| Friday, September 20 |
| » Lost to Yankees (101-53), 5-4 | Yankee Stadium (1-5) | 69-84 | |
| » Starters: Diego Segui vs Whitey Ford | Eighth | 30½ out |
| » Defeated Yankees (101-54), 4-3 | Yankee Stadium (2-5) | 70-84 | |
| » Starters: Orlando Pena vs Jim Bouton | Eighth | 30½ out |
| Saturday, September 21 |
| » Defeated Yankees (101-55), 5-3 | Yankee Stadium (3-5) | 71-84 | Won 2 |
| » Starters: Moe Drabowsky vs Ralph Terry | Eighth | 29½ out |
| Future Athletic Troy Afenir is born in Escondido, CA. |
| Sunday, September 22 |
| » Lost to Yankees (102-55), 4-3 | Yankee Stadium (3-6) | 71-85 | |
| » Starters: Dave Wickersham vs Al Downing | Eighth | 30½ out |
| Tuesday, September 24 |
| » Lost to Red Sox (75-84), 5-1 | Fenway Park (6-2) | 71-86 | Lost 2 |
| » Starters: Diego Segui vs Dave Morehead | Eighth | 31½ out |
| Wednesday, September 25 |
| » Defeated Red Sox (75-85), 7-6 | Fenway Park (7-2) | 72-86 | |
| » Starters: Orlando Pena vs Jack Lamabe | Eighth | 31½ out |
| Thursday, September 26 |
| » Lost to Indians (77-82), 4-1 | Municipal Stadium (35-43) | 72-87 | |
| » Starters: Tommy John vs Moe Drabowsky | Eighth | 32 out |
| Friday, September 27 |
| » Defeated Indians (77-83), 3-1 | Municipal Stadium (36-43) | 73-87 | |
| » Starters: Gordon Seyfried vs Dave Wickersham | Eighth | 31 out |
| Saturday, September 28 |
| » Lost to Indians (78-83), 7-0 | Municipal Stadium (36-44) | 73-88 | |
| » Starters: Jack Kralick vs Fred Norman | Seventh | 31 out |
| Sunday, September 29 |
| » Lost to In |
