| Monday, January 7 |
| Future Astro Craig Shipley is born in Parramatta, Australia. |
| Tuesday, January 29 |
| Future Astro Brian Meyer is born in Camden, NJ. |
| Sunday, March 10 |
| Future Astro John Cangelosi is born in Brooklyn, NY. |
| Tuesday, March 19 |
| Future Astro Chuck Jackson is born in Seattle, WA. |
| Wednesday, March 20 |
| Future Astro Rick Parker is born in Kansas City, MO. |
| Monday, April 8 |
| » Major-league debuts: Tom Brown (Senators) |
| Tuesday, April 9 |
| » Lost to Giants (1-0), 9-2 | Colt Stadium (0-1) | 0-1 | |
| » Starters: Jack Sanford vs Turk Farrell | Third | 1 out |
| » Major-league debuts: Brock Davis and Rusty Staub (Astros) |
| Future Astro Mike Brumley is born in Oklahoma City, OK. |
| Wednesday, April 10 |
| » Lost to Giants (2-0), 8-7 | Colt Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Juan Marichal vs Bob Bruce | Fourth | 2 out |
| Thursday, April 11 |
| » Lost to Giants (3-0), 7-1 | Colt Stadium (0-3) | 0-3 | Lost 3 |
| » Starters: Billy O'Dell vs Ken Johnson | Fifth | 3 out |
| » Major-league debuts: Chris Zachary (Astros) |
| Friday, April 12 |
| » Defeated Dodgers (2-2), 2-1 | Colt Stadium (1-3) | 1-3 | |
| » Starters: Bob Miller vs Turk Farrell | Sixth | 2½ out |
| Saturday, April 13 |
| » Lost to Dodgers (3-2), 3-1 | Colt Stadium (1-4) | 1-4 | |
| » Starters: Don Drysdale vs George Brunet | Eighth | 3½ out |
| Sunday, April 14 |
| » Defeated Dodgers (3-3), 5-4 | Colt Stadium (2-4) | 2-4 | |
| » Starters: Sandy Koufax vs Don Nottebart | Fifth | 2½ out |
| Tuesday, April 16 |
| » Lost to Giants (5-1), 7-0 | Candlestick Park (0-1) | 2-5 | |
| » Starters: Bob Bruce vs Billy Pierce | Seventh | 3½ out |
| Wednesday, April 17 |
| » Defeated Giants (5-2), 2-1 | Candlestick Park (1-1) | 3-5 | |
| » Starters: Ken Johnson vs Billy O'Dell | Sixth | 3 out |
| Thursday, April 18 |
| » Lost to Giants (6-2), 6-3 | Candlestick Park (1-2) | 3-6 | |
| » Starters: George Brunet vs Jack Sanford | Seventh | 4 out |
| Friday, April 19 |
| » Lost to Dodgers (5-5), 2-0 | Dodger Stadium (0-1) | 3-7 | Lost 2 |
| » Starters: Turk Farrell vs Sandy Koufax | Eighth | 4½ out |
| » Major-league debuts: John Bateman (Astros) |
| Saturday, April 20 |
| » Defeated Dodgers (5-6), 9-6 | Dodger Stadium (1-1) | 4-7 | |
| » Starters: Don Nottebart vs Johnny Podres | Eighth | 3½ out |
| Sunday, April 21 |
| » Lost to Dodgers (6-6), 11-3 | Dodger Stadium (1-2) | 4-8 | |
| » Starters: Conrad Cardinal vs Bob Miller | Eighth | 4½ out |
| » Lost to Dodgers (7-6), 6-5 | Dodger Stadium (1-3) | 4-9 | Lost 2 |
| » Starters: Bob Bruce vs Pete Richert | Eighth | 4½ out |
| Future Astro Ken Caminiti is born in Hanford, CA. |
| Monday, April 22 |
| » Lost to Cardinals (8-5), 5-2 | Colt Stadium (2-5) | 4-10 | Lost 3 |
| » Starters: Ray Washburn vs Ken Johnson | Ninth | 4½ out |
| Tuesday, April 23 |
| » Lost to Cardinals (9-5), 15-0 | Colt Stadium (2-6) | 4-11 | Lost 4 |
| » Starters: Ernie Broglio vs Jim Golden | Eighth | 5½ out |
| Wednesday, April 24 |
| » Lost to Braves (9-7), 4-3 | Colt Stadium (2-7) | 4-12 | Lost 5 |
| » Starters: Warren Spahn vs Turk Farrell | Ninth | 6½ out |
| Thursday, April 25 |
| » Defeated Braves (9-8), 7-5 | Colt Stadium (3-7) | 5-12 | |
| » Starters: Tony Cloninger vs Don Nottebart | Ninth | 5½ out |
| Friday, April 26 |
| » Defeated Reds (5-9), 2-0 | Colt Stadium (4-7) | 6-12 | Won 2 |
| » Starters: Jim Maloney vs Bob Bruce | Ninth | 5½ out |
| Saturday, April 27 |
| » Lost to Reds (6-9), 1-0 | Colt Stadium (4-8) | 6-13 | |
| » Starters: Jim O'Toole vs Ken Johnson | Tenth | 6½ out |
| Sunday, April 28 |
| » Defeated Reds (6-10), 3-2 | Colt Stadium (5-8) | 7-13 | |
| » Starters: Joe Nuxhall vs Hal Brown | Ninth | 6 out |
| Thursday, May 2 |
| » Lost to Mets (8-12), 10-3 | Polo Grounds V (0-1) | 7-14 | |
| » Starters: Don Nottebart vs Al Jackson | Tenth | 7½ out |
| Friday, May 3 |
| » Lost to Phillies (9-11), 4-3 | Shibe Park (0-1) | 7-15 | Lost 2 |
| » Starters: Bob Bruce vs Chris Short | Tenth | 7½ out |
| Saturday, May 4 |
| » Lost to Phillies (10-11), 7-0 | Shibe Park (0-2) | 7-16 | Lost 3 |
| » Starters: Ken Johnson vs Ray Culp | Ninth | 7½ out |
| Sunday, May 5 |
| » Lost to Phillies (11-11), 6-5 | Shibe Park (0-3) | 7-17 | Lost 4 |
| » Starters: Hal Brown vs Cal McLish | Ninth | 7 out |
| » Defeated Phillies (11-12), 6-2 | Shibe Park (1-3) | 8-17 | |
| » Starters: Turk Farrell vs Johnny Klippstein | Ninth | 7 out |
| Tuesday, May 7 |
| » Defeated Reds (10-13), 3-2 | Crosley Field (1-0) | 9-17 | Won 2 |
| » Starters: Don Nottebart vs Bob Purkey | Ninth | 7½ out |
| Wednesday, May 8 |
| » Lost to Reds (11-13), 3-2 | Crosley Field (1-1) | 9-18 | |
| » Starters: Bob Bruce vs Joe Nuxhall | Tenth | 8½ out |
| Thursday, May 9 |
| » Lost to Reds (12-13), 13-3 | Crosley Field (1-2) | 9-19 | Lost 2 |
| » Starters: Ken Johnson vs Jim Maloney | Tenth | 9½ out |
| Friday, May 10 |
| » Defeated Cubs (16-12), 4-1 | Colt Stadium (6-8) | 10-19 | |
| » Starters: Glen Hobbie vs Turk Farrell | Tenth | 8½ out |
| Saturday, May 11 |
| » Defeated Cubs (16-13), 5-3 | Colt Stadium (7-8) | 11-19 | Won 2 |
| » Starters: Cal Koonce vs Hal Brown | Tenth | 7 out |
| » Defeated Cubs (16-14), 1-0 | Colt Stadium (8-8) | 12-19 | Won 3 |
| » Starters: Larry Jackson vs Dick Drott | Tenth | 7 out |
| Sunday, May 12 |
| » Defeated Cubs (16-15), 2-1 | Colt Stadium (9-8) | 13-19 | Won 4 |
| » Starters: Bob Buhl vs Don Nottebart | Tenth | 6 out |
| Monday, May 13 |
| » Defeated Mets (14-18), 4-2 | Colt Stadium (10-8) | 14-19 | Won 5 |
| » Starters: Roger Craig vs Bob Bruce | Ninth | 5½ out |
| Tuesday, May 14 |
| » Defeated Mets (14-19), 4-3 | Colt Stadium (11-8) | 15-19 | Won 6 |
| » Starters: Carl Willey vs Turk Farrell | Eighth | 5½ out |
| Wednesday, May 15 |
| » Lost to Mets (15-19), 7-4 | Colt Stadium (11-9) | 15-20 | |
| » Starters: Al Jackson vs Ken Johnson | Tenth | 6½ out |
| Thursday, May 16 |
| » Lost to Phillies (16-17), 5-2 | Colt Stadium (11-10) | 15-21 | Lost 2 |
| » Starters: Ray Culp vs Dick Drott | Tenth | 7½ out |
| Friday, May 17 |
| » Defeated Phillies (16-18), 4-1 | Colt Stadium (12-10) | 16-21 | |
| » Starters: Jack Hamilton vs Don Nottebart | Ninth | 7½ out |
| Saturday, May 18 |
| » Defeated Phillies (16-19), 3-2 | Colt Stadium (13-10) | 17-21 | Won 2 |
| » Starters: Dallas Green vs Bob Bruce | Eighth | 6½ out |
| Sunday, May 19 |
| » Lost to Pirates (17-18), 5-0 | Colt Stadium (13-11) | 17-22 | |
| » Starters: Bob Friend vs Turk Farrell | Eighth | 7 out |
| Monday, May 20 |
| » Defeated Pirates (17-19), 2-0 | Colt Stadium (14-11) | 18-22 | |
| » Starters: Don Cardwell vs Dick Drott | Ninth | 6½ out |
| Tuesday, May 21 |
| » Lost to Pirates (18-19), 6-5 | Colt Stadium (14-12) | 18-23 | |
| » Starters: Don Schwall vs Ken Johnson | Ninth | 7½ out |
| Wednesday, May 22 |
| » Lost to Pirates (19-19), 4-3 | Colt Stadium (14-13) | 18-24 | Lost 2 |
| » Starters: Vern Law vs Don Nottebart | Ninth | 8½ out |
| Friday, May 24 |
| » Defeated Cubs (20-21), 6-5 | Wrigley Field (1-0) | 19-24 | |
| » Starters: Bob Bruce vs Cal Koonce | Ninth | 8½ out |
| Saturday, May 25 |
| » Lost to Cubs (21-21), 4-1 | Wrigley Field (1-1) | 19-25 | |
| » Starters: Turk Farrell vs Larry Jackson | Ninth | 9½ out |
| Sunday, May 26 |
| » Lost to Cubs (22-21), 5-1 | Wrigley Field (1-2) | 19-26 | Lost 2 |
| » Starters: Dick Drott vs Bob Buhl | Ninth | 9½ out |
| Tuesday, May 28 |
| » Lost to Cardinals (26-21), 8-7 | Sportsman's Park III (0-1) | 19-27 | Lost 3 |
| » Starters: Don Nottebart vs Ernie Broglio | Eighth | 9½ out |
| Wednesday, May 29 |
| » Lost to Cardinals (27-21), 3-2 | Sportsman's Park III (0-2) | 19-28 | Lost 4 |
| » Starters: Bob Bruce vs Ray Washburn | Ninth | 10½ out |
| Thursday, May 30 |
| » Lost to Cardinals (28-21), 9-5 | Sportsman's Park III (0-3) | 19-29 | Lost 5 |
| » Starters: Turk Farrell vs Ray Sadecki | Ninth | 11½ out |
| Friday, May 31 |
| » Defeated Braves (21-26), 3-2 | County Stadium (1-0) | 20-29 | |
| » Starters: Ken Johnson vs Bob Shaw | Ninth | 10½ out |
| Saturday, June 1 |
| » Lost to Braves (22-26), 4-1 | County Stadium (1-1) | 20-30 | |
| » Starters: Don Nottebart vs Lew Burdette | Eighth | 10½ out |
| Sunday, June 2 |
| » Defeated Braves (22-27), 3-1 | County Stadium (2-1) | 21-30 | |
| » Starters: Bob Bruce vs Denny Lemaster | Ninth | 10½ out |
| Monday, June 3 |
| » Defeated Dodgers (27-23), 2-1 | Colt Stadium (15-13) | 22-30 | Won 2 |
| » Starters: Don Drysdale vs Turk Farrell | Eighth | 10 out |
| Tuesday, June 4 |
| » Lost to Dodgers (28-23), 2-1 | Colt Stadium (15-14) | 22-31 | |
| » Starters: Bob Miller vs Dick Drott | Seventh | 10 out |
| Wednesday, June 5 |
| » Lost to Dodgers (29-23), 5-1 | Colt Stadium (15-15) | 22-32 | Lost 2 |
| » Starters: Sandy Koufax vs Ken Johnson | Seventh | 9½ out |
| Friday, June 7 |
| » Defeated Giants (31-24), 2-1 | Colt Stadium (16-15) | 23-32 | |
| » Starters: Bobby Bolin vs Don Nottebart | Seventh | 8 out |
| Saturday, June 8 |
| » Defeated Giants (31-25), 2-1 | Colt Stadium (17-15) | 24-32 | Won 2 |
| » Starters: Billy O'Dell vs Bob Bruce | Eighth | 8 out |
| Sunday, June 9 |
| » Defeated Giants (31-26), 3-0 | Colt Stadium (18-15) | 25-32 | Won 3 |
| » Starters: Jack Sanford vs Turk Farrell | Eighth | 8 out |
| Monday, June 10 |
| » Lost to Cubs (32-26), 3-2 | Colt Stadium (18-16) | 25-33 | |
| » Starters: Glen Hobbie vs Dick Drott | Seventh | 8 out |
| Tuesday, June 11 |
| » Defeated Cubs (32-27), 6-2 | Colt Stadium (19-16) | 26-33 | |
| » Starters: Larry Jackson vs Ken Johnson | Ninth | 8 out |
| Wednesday, June 12 |
| » Lost to Dodgers (33-25), 9-1 | Dodger Stadium (1-4) | 26-34 | |
| » Starters: Don Nottebart vs Johnny Podres | Seventh | 8 out |
| Thursday, June 13 |
| » Lost to Dodgers (34-25), 3-0 | Dodger Stadium (1-5) | 26-35 | Lost 2 |
| » Starters: Bob Bruce vs Sandy Koufax | Seventh | 9 out |
| Friday, June 14 |
| » Lost to Giants (36-26), 2-1 | Candlestick Park (1-3) | 26-36 | Lost 3 |
| » Starters: Hal Brown vs Jack Sanford | Seventh | 10 out |
| Saturday, June 15 |
| » Lost to Giants (37-26), 1-0 | Candlestick Park (1-4) | 26-37 | Lost 4 |
| » Starters: Dick Drott vs Juan Marichal | Ninth | 11 out |
| Sunday, June 16 |
| » Defeated Giants (37-27), 3-0 | Candlestick Park (2-4) | 27-37 | |
| » Starters: Don Nottebart vs Bobby Bolin | Ninth | 11 out |
| » Lost to Giants (38-27), 4-3 | Candlestick Park (2-5) | 27-38 | |
| » Starters: Ken Johnson vs Gaylord Perry | Ninth | 11 out |
| Tuesday, June 18 |
| » Lost to Cubs (35-31), 3-1 | Wrigley Field (1-3) | 27-39 | Lost 2 |
| » Starters: Bob Bruce vs Dick Ellsworth | Ninth | 12 out |
| Wednesday, June 19 |
| » Lost to Cubs (36-31), 9-1 | Wrigley Field (1-4) | 27-40 | Lost 3 |
| » Starters: Hal Brown vs Glen Hobbie | Eighth | 13 out |
| Thursday, June 20 |
| » Lost to Cubs (37-31), 5-0 | Wrigley Field (1-5) | 27-41 | Lost 4 |
| » Starters: Dick Drott vs Larry Jackson | Ninth | 13½ out |
| Friday, June 21 |
| » Lost to Reds (37-30), 3-0 | Crosley Field (1-3) | 27-42 | Lost 5 |
| » Starters: Ken Johnson vs Jim Maloney | Ninth | 13½ out |
| Saturday, June 22 |
| » Lost to Reds (38-30), 3-0 | Crosley Field (1-4) | 27-43 | Lost 6 |
| » Starters: Bob Bruce vs John Tsitouris | Eighth | 14½ out |
| Sunday, June 23 |
| » Lost to Reds (39-30), 4-0 | Crosley Field (1-5) | 27-44 | Lost 7 |
| » Starters: Jim Umbricht vs Bob Purkey | Tenth | 15 out |
| » Lost to Reds (40-30), 8-1 | Crosley Field (1-6) | 27-45 | Lost 8 |
| » Starters: Chris Zachary vs Joe Nuxhall | Tenth | 15 out |
| Monday, June 24 |
| » Lost to Braves (35-35), 3-0 | County Stadium (2-2) | 27-46 | Lost 9 |
| » Starters: Hal Brown vs Denny Lemaster | Tenth | 15½ out |
| Tuesday, June 25 |
| » Lost to Braves (36-35), 4-0 | County Stadium (2-3) | 27-47 | Lost 10 |
| » Starters: Ken Johnson vs Tony Cloninger | Tenth | 16 out |
| Wednesday, June 26 |
| » Defeated Braves (36-36), 7-2 | County Stadium (3-3) | 28-47 | |
| » Starters: Bob Bruce vs Bob Shaw | Tenth | 16 out |
| Friday, June 28 |
| » Lost to Cardinals (44-30), 9-2 | Colt Stadium (19-17) | 28-48 | |
| » Starters: Bob Gibson vs Dick Drott | Ninth | 17 out |
| Saturday, June 29 |
| » Lost to Cardinals (45-30), 2-1 | Colt Stadium (19-18) | 28-49 | Lost 2 |
| » Starters: Ernie Broglio vs Ken Johnson | Tenth | 18 out |
| Sunday, June 30 |
| » Defeated Cardinals (45-31), 1-0 | Colt Stadium (20-18) | 29-49 | |
| » Starters: Lew Burdette vs Hal Brown | Tenth | 17 out |
| Monday, July 1 |
| » Defeated Cardinals (45-32), 4-3 | Colt Stadium (21-18) | 30-49 | Won 2 |
| » Starters: Ray Sadecki vs Bob Bruce | Ninth | 16 out |
| Tuesday, July 2 |
| » Lost to Reds (43-35), 6-4 | Colt Stadium (21-19) | 30-50 | |
| » Starters: Bob Purkey vs Don McMahon | Ninth | 16½ out |
| » Major-league debuts: Jim Dickson (Astros) |
| Wednesday, July 3 |
| » Lost to Reds (44-35), 2-1 | Colt Stadium (21-20) | 30-51 | Lost 2 |
| » Starters: John Tsitouris vs Jim Umbricht | Ninth | 17½ out |
| Thursday, July 4 |
| » Defeated Reds (44-36), 5-2 | Colt Stadium (22-20) | 31-51 | |
| » Starters: Joe Nuxhall vs Ken Johnson | Ninth | 17 out |
| » Defeated Reds (44-37), 6-2 | Colt Stadium (23-20) | 32-51 | Won 2 |
| » Starters: Joey Jay vs Chris Zachary | Ninth | 17 out |
| Friday, July 5 |
| » Defeated Braves (40-40), 4-2 | Colt Stadium (24-20) | 33-51 | Won 3 |
| » Starters: Bob Sadowski vs Bob Bruce | Ninth | 17 out |
| Saturday, July 6 |
| » Lost to Braves (41-40), 7-1 | Colt Stadium (24-21) | 33-52 | |
| » Starters: Denny Lemaster vs Don McMahon | Ninth | 17½ out |
| » Lost to Braves (42-40), 2-0 | Colt Stadium (24-22) | 33-53 | Lost 2 |
| » Starters: Bob Shaw vs Hal Brown | Ninth | 17½ out |
| Sunday, July 7 |
| » Lost to Braves (43-40), 4-0 | Colt Stadium (24-23) | 33-54 | Lost 3 |
| » Starters: Warren Spahn vs Jim Umbricht | Ninth | 19 out |
| Wednesday, July 10 |
| » Defeated Pirates (41-43), 2-0 | Forbes Field (1-0) | 34-54 | |
| » Starters: Ken Johnson vs Bob Friend | Ninth | 19 out |
| » Major-league debuts: Jimmy Wynn (Astros) |
| Thursday, July 11 |
| » Lost to Pirates (42-43), 3-0 | Forbes Field (1-1) | 34-55 | |
| » Starters: Turk Farrell vs Don Cardwell | Ninth | 20 out |
| Friday, July 12 |
| » Lost to Pirates (43-43), 2-1 | Forbes Field (1-2) | 34-56 | Lost 2 |
| » Starters: Bob Bruce vs Don Schwall | Ninth | 21 out |
| Saturday, July 13 |
| » Lost to Pirates (44-43), 3-0 | Forbes Field (1-3) | 34-57 | Lost 3 |
| » Starters: Dick Drott vs Vern Law | Ninth | 22 out |
| Sunday, July 14 |
| » Defeated Mets (29-60), 8-3 | Polo Grounds V (1-1) | 35-57 | |
| » Starters: Hal Brown vs Galen Cisco | Ninth | 22 out |
| Monday, July 15 |
| » Lost to Mets (30-60), 14-5 | Polo Grounds V (1-2) | 35-58 | |
| » Starters: Ken Johnson vs Carl Willey | Eighth | 21½ out |
| » Defeated Mets (30-61), 8-0 | Polo Grounds V (2-2) | 36-58 | |
| » Starters: Don Nottebart vs Roger Craig | Eighth | 21½ out |
| Tuesday, July 16 |
| » Lost to Mets (31-61), 4-3 | Polo Grounds V (2-3) | 36-59 | |
| » Starters: Turk Farrell vs Al Jackson | Ninth | 22 out |
| Wednesday, July 17 |
| » Lost to Phillies (46-47), 10-9 | Shibe Park (1-4) | 36-60 | Lost 2 |
| » Starters: Bob Bruce vs Ryne Duren | Eighth | 23 out |
| Thursday, July 18 |
| » Lost to Phillies (47-47), 5-1 | Shibe Park (1-5) | 36-61 | Lost 3 |
| » Starters: Ken Johnson vs John Boozer | Eighth | 24 out |
| Friday, July 19 |
| » Lost to Cardinals (52-43), 7-2 | Sportsman's Park III (0-4) | 36-62 | Lost 4 |
| » Starters: Dick Drott vs Ernie Broglio | Eighth | 25 out |
| Saturday, July 20 |
| » Lost to Cardinals (53-43), 8-1 | Sportsman's Park III (0-5) | 36-63 | Lost 5 |
| » Starters: Turk Farrell vs Curt Simmons | Ninth | 26 out |
| Sunday, July 21 |
| » Lost to Cardinals (54-43), 9-4 | Sportsman's Park III (0-6) | 36-64 | Lost 6 |
| » Starters: Hal Brown vs Bob Gibson | Eighth | 25½ out |
| Tuesday, July 23 |
| » Defeated Phillies (51-48), 6-5 | Colt Stadium (25-23) | 37-64 | |
| » Starters: John Boozer vs Bob Bruce | Eighth | 25½ out |
| Wednesday, July 24 |
| » Lost to Phillies (52-48), 6-3 | Colt Stadium (25-24) | 37-65 | |
| » Starters: Cal McLish vs Ken Johnson | Ninth | 26½ out |
| Thursday, July 25 |
| » Defeated Phillies (52-49), 3-0 | Colt Stadium (26-24) | 38-65 | |
| » Starters: Ray Culp vs Hal Brown | Ninth | 25½ out |
| Friday, July 26 |
| » Defeated Mets (32-70), 7-3 | Colt Stadium (27-24) | 39-65 | Won 2 |
| » Starters: Tracy Stallard vs Turk Farrell | Ninth | 24½ out |
| Saturday, July 27 |
| » Defeated Mets (32-71), 1-0 | Colt Stadium (28-24) | 40-65 | Won 3 |
| » Starters: Roger Craig vs Bob Bruce | Ninth | 23½ out |
| Sunday, July 28 |
| » Defeated Mets (32-72), 8-2 | Colt Stadium (29-24) | 41-65 | Won 4 |
| » Starters: Al Jackson vs Ken Johnson | Eighth | 22½ out |
| Tuesday, July 30 |
| » Lost to Pirates (51-53), 8-1 | Colt Stadium (29-25) | 41-66 | |
| » Starters: Joe Gibbon vs Hal Brown | Ninth | 23 out |
| Wednesday, July 31 |
| » Lost to Pirates (52-53), 6-3 | Colt Stadium (29-26) | 41-67 | Lost 2 |
| » Starters: Bob Friend vs Don Nottebart | Ninth | 24 out |
| Friday, August 2 |
| » Defeated Dodgers (64-43), 4-1 | Colt Stadium (30-26) | 42-67 | |
| » Starters: Don Drysdale vs Turk Farrell | Ninth | 23 out |
| Saturday, August 3 |
| » Lost to Dodgers (65-43), 2-0 | Colt Stadium (30-27) | 42-68 | |
| » Starters: Sandy Koufax vs Bob Bruce | Ninth | 24 out |
| Sunday, August 4 |
| » Lost to Dodgers (66-43), 4-0 | Colt Stadium (30-28) | 42-69 | Lost 2 |
| » Starters: Johnny Podres vs Ken Johnson | Ninth | 25 out |
| Monday, August 5 |
| » Defeated Giants (62-49), 6-5 | Colt Stadium (31-28) | 43-69 | |
| » Starters: Juan Marichal vs Don Nottebart | Eighth | 24½ out |
| Tuesday, August 6 |
| » Lost to Giants (63-49), 3-1 | Colt Stadium (31-29) | 43-70 | |
| » Starters: Jim Duffalo vs Hal Brown | Eighth | 25½ out |
| Wednesday, August 7 |
| » Defeated Giants (63-50), 1-0 | Colt Stadium (32-29) | 44-70 | |
| » Starters: Jack Sanford vs Turk Farrell | Eighth | 25½ out |
| Friday, August 9 |
| » Defeated Pirates (56-57), 7-6 | Forbes Field (2-3) | 45-70 | Won 2 |
| » Starters: Ken Johnson vs Joe Gibbon | Ninth | 24½ out |
| » Lost to Pirates (57-57), 7-6 | Forbes Field (2-4) | 45-71 | |
| » Starters: Bob Bruce vs Earl Francis | Ninth | 24½ out |
| Saturday, August 10 |
| » Lost to Pirates (58-57), 3-2 | Forbes Field (2-5) | 45-72 | Lost 2 |
| » Starters: Don Nottebart vs Don Cardwell | Ninth | 25½ out |
| Sunday, August 11 |
| » Lost to Pirates (59-57), 2-1 | Forbes Field (2-6) | 45-73 | Lost 3 |
| » Starters: Hal Brown vs Joe Gibbon | Ninth | 25½ out |
| Monday, August 12 |
| » Lost to Pirates (60-57), 4-2 | Forbes Field (2-7) | 45-74 | Lost 4 |
| » Starters: Turk Farrell vs Bob Friend | Ninth | 26 out |
| Tuesday, August 13 |
| » Lost to Cardinals (65-53), 4-2 | Sportsman's Park III (0-7) | 45-75 | Lost 5 |
| » Starters: Bob Bruce vs Ernie Broglio | Ninth | 26 out |
| Wednesday, August 14 |
| » Lost to Cardinals (66-53), 3-2 | Sportsman's Park III (0-8) | 45-76 | Lost 6 |
| » Starters: Ken Johnson vs Bob Gibson | Ninth | 26 out |
| Thursday, August 15 |
| » Defeated Cardinals (66-54), 4-2 | Sportsman's Park III (1-8) | 46-76 | |
| » Starters: Don Nottebart vs Ray Sadecki | Ninth | 26 out |
| Friday, August 16 |
| » Lost to Braves (62-60), 3-2 | County Stadium (3-4) | 46-77 | |
| » Starters: Turk Farrell vs Tony Cloninger | Ninth | 27 out |
| Saturday, August 17 |
| » Lost to Braves (63-60), 4-1 | County Stadium (3-5) | 46-78 | Lost 2 |
| » Starters: Dick Drott vs Denny Lemaster | Eighth | 28 out |
| Sunday, August 18 |
| » Lost to Braves (64-60), 3-2 | County Stadium (3-6) | 46-79 | Lost 3 |
| » Starters: Hal Brown vs Warren Spahn | Eighth | 29½ out |
| Tuesday, August 20 |
| » Lost to Reds (68-61), 1-0 | Colt Stadium (32-30) | 46-80 | Lost 4 |
| » Starters: Joe Nuxhall vs Ken Johnson | Ninth | 30½ out |
| Wednesday, August 21 |
| » Defeated Reds (68-62), 1-0 | Colt Stadium (33-30) | 47-80 | |
| » Starters: Jim O'Toole vs Don Nottebart | Ninth | 30½ out |
| Friday, August 23 |
| » Lost to Cardinals (71-56), 4-1 | Colt Stadium (33-31) | 47-81 | |
| » Starters: Bob Gibson vs Turk Farrell | Ninth | 30 out |
| Saturday, August 24 |
| » Defeated Cardinals (71-57), 4-0 | Colt Stadium (34-31) | 48-81 | |
| » Starters: Ron Taylor vs Hal Brown | Eighth | 29 out |
| Sunday, August 25 |
| » Defeated Cardinals (71-58), 3-1 | Colt Stadium (35-31) | 49-81 | Won 2 |
| » Starters: Lew Burdette vs Chris Zachary | Eighth | 29 out |
| Monday, August 26 |
| » Lost to Braves (69-62), 11-7 | Colt Stadium (35-32) | 49-82 | |
| » Starters: Bob Hendley vs Ken Johnson | Ninth | 29 out |
| Tuesday, August 27 |
| » Lost to Braves (70-62), 3-2 | Colt Stadium (35-33) | 49-83 | Lost 2 |
| » Starters: Warren Spahn vs Don Nottebart | Eighth | 30 out |
| Wednesday, August 28 |
| » Lost to Braves (71-62), 9-1 | Colt Stadium (35-34) | 49-84 | Lost 3 |
| » Starters: Tony Cloninger vs Turk Farrell | Ninth | 30 out |
| Friday, August 30 |
| » Defeated Cubs (68-65), 5-1 | Wrigley Field (2-5) | 50-84 | |
| » Starters: Ken Johnson vs Cal Koonce | Ninth | 30½ out |
| Saturday, August 31 |
| » Lost to Cubs (69-65), 6-5 | Wrigley Field (2-6) | 50-85 | |
| » Starters: Hal Brown vs Larry Jackson | Ninth | 30½ out |
| Sunday, September 1 |
| » Lost to Cubs (70-65), 4-3 | Wrigley Field (2-7) | 50-86 | Lost 2 |
| » Starters: Don Nottebart vs Bob Buhl | Ninth | 31½ out |
| Monday, September 2 |
| » Lost to Dodgers (82-54), 7-3 | Dodger Stadium (1-6) | 50-87 | Lost 3 |
| » Starters: Turk Farrell vs Sandy Koufax | Ninth | 33½ out |
| » Lost to Dodgers (83-54), 7-1 | Dodger Stadium (1-7) | 50-88 | Lost 4 |
| » Starters: Chris Zachary vs Johnny Podres | Ninth | 33½ out |
| Tuesday, September 3 |
| » Lost to Dodgers (84-54), 4-3 | Dodger Stadium (1-8) | 50-89 | Lost 5 |
| » Starters: Ken Johnson vs Don Drysdale | Ninth | 34½ out |
| Wednesday, September 4 |
| » Lost to Giants (76-64), 8-3 | Candlestick Park (2-6) | 50-90 | Lost 6 |
| » Starters: Dick Drott vs Jack Sanford | Ninth | 34½ out |
| Thursday, September 5 |
| » Defeated Giants (76-65), 5-2 | Candlestick Park (3-6) | 51-90 | |
| » Starters: Don Nottebart vs Bobby Bolin | Eighth | 34½ out |
| Friday, September 6 |
| » Lost to Cubs (74-67), 3-0 | Colt Stadium (35-35) | 51-91 | |
| » Starters: Glen Hobbie vs Hal Brown | Ninth | 35½ out |
| Saturday, September 7 |
| » Defeated Cubs (74-68), 2-1 | Colt Stadium (36-35) | 52-91 | |
| » Starters: Dick Ellsworth vs Turk Farrell | Ninth | 34½ out |
| Sunday, September 8 |
| » Defeated Cubs (74-69), 2-1 | Colt Stadium (37-35) | 53-91 | Won 2 |
| » Starters: Larry Jackson vs Ken Johnson | Ninth | 33½ out |
| Monday, September 9 |
| » Major-league debuts: Billy Cowan (Cubs) |
| Tuesday, September 10 |
| » Lost to Phillies (76-69), 16-0 | Shibe Park (1-6) | 53-92 | |
| » Starters: Don Nottebart vs Chris Short | Ninth | 34½ out |
| Future Astro Randy Johnson is born in Walnut Creek, CA. |
| Wednesday, September 11 |
| » Defeated Phillies (76-70), 4-2 | Shibe Park (2-6) | 54-92 | |
| » Starters: Turk Farrell vs Cal McLish | Ninth | 34½ out |
| Thursday, September 12 |
| » Lost to Phillies (77-70), 4-1 | Shibe Park (2-7) | 54-93 | |
| » Starters: Hal Brown vs Ray Culp | Ninth | 35½ out |
| Friday, September 13 |
| » Defeated Mets (49-99), 1-0 | Polo Grounds V (3-3) | 55-93 | |
| » Starters: Don Nottebart vs Roger Craig | Ninth | 35 out |
| Saturday, September 14 |
| » Defeated Mets (49-100), 4-0 | Polo Grounds V (4-3) | 56-93 | Won 2 |
| » Starters: Ken Johnson vs Carl Willey | Eighth | 35 out |
| » Major-league debuts: Cleon Jones (Mets) |
| Sunday, September 15 |
| » Defeated Mets (49-101), 5-4 | Polo Grounds V (5-3) | 57-93 | Won 3 |
| » Starters: Turk Farrell vs Al Jackson | Ninth | 33½ out |
| » Defeated Mets (49-102), 5-0 | Polo Grounds V (6-3) | 58-93 | Won 4 |
| » Starters: Chris Zachary vs Jay Hook | Ninth | 33½ out |
| Tuesday, September 17 |
| » Lost to Reds (81-73), 4-3 | Crosley Field (1-7) | 58-94 | |
| » Starters: Don Nottebart vs Joe Nuxhall | Ninth | 35 out |
| Wednesday, September 18 |
| » Defeated Reds (81-74), 8-4 | Crosley Field (2-7) | 59-94 | |
| » Starters: Dick Drott vs Jim Maloney | Ninth | 35 out |
| Friday, September 20 |
| » Defeated Phillies (81-73), 3-2 | Colt Stadium (38-35) | 60-94 | Won 2 |
| » Starters: Dennis Bennett vs Ken Johnson | Ninth | 35 out |
| » Major-league debuts: Glenn Vaughan (Astros) |
| Saturday, September 21 |
| » Lost to Phillies (82-73), 4-3 | Colt Stadium (38-36) | 60-95 | |
| » Starters: Dallas Green vs Don Nottebart | Eighth | 36 out |
| » Major-league debuts: Jerry Grote and Joe Morgan (Astros) |
| Future Astro Troy Afenir is born in Escondido, CA. |
| Sunday, September 22 |
| » Defeated Phillies (82-74), 2-1 | Colt Stadium (39-36) | 61-95 | |
| » Starters: Chris Short vs Hal Brown | Ninth | 35 out |
| » Major-league debuts: Aaron Pointer (Astros) |
| Monday, September 23 |
| Future Astro Terry McGriff is born in Fort Pierce, FL. |
| Tuesday, September 24 |
| » Defeated Pirates (73-84), 3-2 | Colt Stadium (40-36) | 62-95 | Won 2 |
| » Starters: Earl Francis vs Chris Zachary | Ninth | |