| Thursday, January 11 |
| Future White Sox Donn Pall is born in Chicago, IL. |
| Sunday, March 4 |
| Former White Sox George Mogridge dies in Rochester, NY at the age of 74. |
| Saturday, March 17 |
| Former White Sox Billy Purtell dies in Bradenton, FL at the age of 77. |
| Monday, March 19 |
| Future White Sox Ivan Calderon is born in Fajardo, P.R. |
| Tuesday, April 10 |
| » Defeated Angels (0-1), 2-1 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: Eli Grba vs Juan Pizarro | First | -- |
| » Major-league debuts: Felix Torres (Angels) |
| Wednesday, April 11 |
| » Major-league debuts: Ron Taylor (Indians) |
| Future White Sox Tim Fortugno is born in Clinton, MA. |
| Thursday, April 12 |
| » Lost to Angels (1-1), 1-0 | Comiskey Park I (1-1) | 1-1 | |
| » Starters: Ken McBride vs Joe Horlen | Third | ½ out |
| Friday, April 13 |
| » Defeated Athletics (1-3), 12-5 | Municipal Stadium (1-0) | 2-1 | |
| » Starters: Ray Herbert vs Art Ditmar | Second | ½ out |
| Future White Sox Jeff Bittiger is born in Jersey City, NJ. |
| Saturday, April 14 |
| » Lost to Athletics (2-3), 7-3 | Municipal Stadium (1-1) | 2-2 | |
| » Starters: John Buzhardt vs Jerry Walker | Third | ½ out |
| Sunday, April 15 |
| » Defeated Athletics (2-4), 8-3 | Municipal Stadium (2-1) | 3-2 | |
| » Starters: Juan Pizarro vs Ed Rakow | Third | ½ out |
| Monday, April 16 |
| » Major-league debuts: Hank Fischer (Braves) |
| Tuesday, April 17 |
| » Defeated Twins (2-4), 8-0 | Metropolitan Stadium (1-0) | 4-2 | Won 2 |
| » Starters: Joe Horlen vs Camilo Pascual | Second | 1 out |
| Wednesday, April 18 |
| » Defeated Twins (2-5), 3-2 | Metropolitan Stadium (2-0) | 5-2 | Won 3 |
| » Starters: Ray Herbert vs Don Lee | First | -- |
| Thursday, April 19 |
| » Defeated Twins (2-6), 10-3 | Metropolitan Stadium (3-0) | 6-2 | Won 4 |
| » Starters: John Buzhardt vs Jim Kaat | First | -- |
| Friday, April 20 |
| » Lost to Athletics (4-6), 7-4 | Comiskey Park I (1-2) | 6-3 | |
| » Starters: Jerry Walker vs Juan Pizarro | First | -- |
| Saturday, April 21 |
| » Lost to Athletics (5-6), 9-6 | Comiskey Park I (1-3) | 6-4 | Lost 2 |
| » Starters: John Wyatt vs Early Wynn | Second | 1½ out |
| Former White Sox Bill Norman dies in Milwaukee, WI at the age of 52. |
| Sunday, April 22 |
| » Lost to Athletics (6-6), 7-1 | Comiskey Park I (1-4) | 6-5 | Lost 3 |
| » Starters: Ed Rakow vs Ray Herbert | Seventh | 2 out |
| » Lost to Athletics (7-6), 7-5 | Comiskey Park I (1-5) | 6-6 | Lost 4 |
| » Starters: Norm Bass vs Joe Horlen | Seventh | 2 out |
| » Major-league debuts: Dave DeBusschere (White Sox) |
| Tuesday, April 24 |
| » Defeated Yankees (5-5), 3-1 | Yankee Stadium (1-0) | 7-6 | |
| » Starters: John Buzhardt vs Ralph Terry | Fourth | 2 out |
| Wednesday, April 25 |
| » Lost to Yankees (6-5), 7-6 | Yankee Stadium (1-1) | 7-7 | |
| » Starters: Juan Pizarro vs Whitey Ford | Seventh | 2 out |
| Friday, April 27 |
| » Defeated Red Sox (7-6), 7-4 | Comiskey Park I (2-5) | 8-7 | |
| » Starters: Bill Monbouquette vs Joe Horlen | Fourth | 1½ out |
| Saturday, April 28 |
| » Defeated Red Sox (7-7), 7-6 | Comiskey Park I (3-5) | 9-7 | Won 2 |
| » Starters: Billy Muffett vs Ray Herbert | Third | 1½ out |
| Future White Sox Russ Morman is born in Independence, MO. |
| Sunday, April 29 |
| » Defeated Red Sox (7-8), 2-1 | Comiskey Park I (4-5) | 10-7 | Won 3 |
| » Starters: Don Schwall vs John Buzhardt | Second | 1½ out |
| » Defeated Red Sox (7-9), 5-1 | Comiskey Park I (5-5) | 11-7 | Won 4 |
| » Starters: Galen Cisco vs Early Wynn | Second | 1½ out |
| Tuesday, May 1 |
| » Lost to Yankees (11-5), 6-1 | Comiskey Park I (5-6) | 11-8 | |
| » Starters: Bill Stafford vs Juan Pizarro | Third | 1½ out |
| Wednesday, May 2 |
| » Lost to Yankees (12-5), 4-3 | Comiskey Park I (5-7) | 11-9 | Lost 2 |
| » Starters: Ralph Terry vs Joe Horlen | Fourth | 2½ out |
| Thursday, May 3 |
| » Defeated Yankees (12-6), 1-0 | Comiskey Park I (6-7) | 12-9 | |
| » Starters: Whitey Ford vs John Buzhardt | Second | 1½ out |
| Friday, May 4 |
| » Lost to Red Sox (9-10), 13-6 | Fenway Park (0-1) | 12-10 | |
| » Starters: Ray Herbert vs Don Schwall | Third | 2 out |
| Saturday, May 5 |
| » Lost to Red Sox (10-10), 8-3 | Fenway Park (0-2) | 12-11 | Lost 2 |
| » Starters: Early Wynn vs Galen Cisco | Fifth | 3 out |
| Sunday, May 6 |
| » Lost to Red Sox (11-10), 3-2 | Fenway Park (0-3) | 12-12 | Lost 3 |
| » Starters: Juan Pizarro vs Gene Conley | Fifth | 3 out |
| » Defeated Red Sox (11-11), 5-3 | Fenway Park (1-3) | 13-12 | |
| » Starters: Joe Horlen vs Earl Wilson | Fifth | 3 out |
| Wednesday, May 9 |
| » Lost to Senators (5-16), 9-3 | Robert F. Kennedy Stadium (0-1) | 13-13 | |
| » Starters: John Buzhardt vs Don Rudolph | Fourth | 3½ out |
| » Defeated Senators (5-17), 7-6 | Robert F. Kennedy Stadium (1-1) | 14-13 | |
| » Starters: Ray Herbert vs Steve Hamilton | Fourth | 3½ out |
| Thursday, May 10 |
| » Defeated Senators (5-18), 3-1 | Robert F. Kennedy Stadium (2-1) | 15-13 | Won 2 |
| » Starters: Early Wynn vs Bennie Daniels | Fourth | 3 out |
| Friday, May 11 |
| » Lost to Angels (13-11), 4-2 | Dodger Stadium (0-1) | 15-14 | |
| » Starters: Juan Pizarro vs Bo Belinsky | Fifth | 3 out |
| Saturday, May 12 |
| » Defeated Angels (13-12), 7-6 | Dodger Stadium (1-1) | 16-14 | |
| » Starters: Joe Horlen vs Dean Chance | Fourth | 3 out |
| Sunday, May 13 |
| » Defeated Angels (13-13), 15-6 | Dodger Stadium (2-1) | 17-14 | Won 2 |
| » Starters: John Buzhardt vs Eli Grba | Fourth | 2 out |
| Tuesday, May 15 |
| » Defeated Senators (6-21), 4-3 | Comiskey Park I (7-7) | 18-14 | Won 3 |
| » Starters: Tom Cheney vs Ray Herbert | Fourth | 2 out |
| Wednesday, May 16 |
| » Lost to Senators (7-21), 3-1 | Comiskey Park I (7-8) | 18-15 | |
| » Starters: Dave Stenhouse vs Early Wynn | Fourth | 2 out |
| Friday, May 18 |
| » Lost to Orioles (17-14), 7-4 | Comiskey Park I (7-9) | 18-16 | Lost 2 |
| » Starters: Jack Fisher vs Juan Pizarro | Fifth | 3 out |
| Saturday, May 19 |
| » Lost to Orioles (18-14), 11-6 | Comiskey Park I (7-10) | 18-17 | Lost 3 |
| » Starters: Steve Barber vs Joe Horlen | Fifth | 3 out |
| Sunday, May 20 |
| » Defeated Orioles (18-15), 8-3 | Comiskey Park I (8-10) | 19-17 | |
| » Starters: Milt Pappas vs John Buzhardt | Fourth | 2 out |
| » Defeated Orioles (18-16), 8-3 | Comiskey Park I (9-10) | 20-17 | Won 2 |
| » Starters: Chuck Estrada vs Ray Herbert | Fourth | 2 out |
| Monday, May 21 |
| » Lost to Tigers (16-17), 7-3 | Comiskey Park I (9-11) | 20-18 | |
| » Starters: Paul Foytack vs Early Wynn | Fifth | 3 out |
| Wednesday, May 23 |
| » Lost to Indians (22-14), 5-4 | Comiskey Park I (9-12) | 20-19 | Lost 2 |
| » Starters: Dick Donovan vs Juan Pizarro | Sixth | 4 out |
| Former White Sox Rip Radcliff dies in Enid, OK at the age of 57. |
| Friday, May 25 |
| » Defeated Twins (23-18), 5-4 | Comiskey Park I (10-12) | 21-19 | |
| » Starters: Jack Kralick vs Joe Horlen | Fifth | 3½ out |
| Saturday, May 26 |
| » Lost to Twins (24-18), 4-1 | Comiskey Park I (10-13) | 21-20 | |
| » Starters: Camilo Pascual vs John Buzhardt | Sixth | 3½ out |
| Sunday, May 27 |
| » Lost to Twins (25-18), 5-4 | Comiskey Park I (10-14) | 21-21 | Lost 2 |
| » Starters: Jim Kaat vs Ray Herbert | Sixth | 5 out |
| » Lost to Twins (26-18), 8-6 | Comiskey Park I (10-15) | 21-22 | Lost 3 |
| » Starters: Don Lee vs Juan Pizarro | Sixth | 5 out |
| Monday, May 28 |
| » Defeated Indians (24-16), 2-0 | Cleveland Stadium (1-0) | 22-22 | |
| » Starters: Early Wynn vs Dick Donovan | Sixth | 4 out |
| Wednesday, May 30 |
| » Lost to Tigers (23-18), 7-3 | Tiger Stadium (0-1) | 22-23 | |
| » Starters: John Buzhardt vs Phil Regan | Seventh | 4 out |
| » Defeated Tigers (23-19), 6-3 | Tiger Stadium (1-1) | 23-23 | |
| » Starters: Joe Horlen vs Sam Jones | Seventh | 4 out |
| Thursday, May 31 |
| » Lost to Tigers (24-19), 13-5 | Tiger Stadium (1-2) | 23-24 | |
| » Starters: Dom Zanni vs Paul Foytack | Seventh | 5 out |
| Friday, June 1 |
| » Defeated Orioles (22-24), 3-2 | Memorial Stadium (1-0) | 24-24 | |
| » Starters: Ray Herbert vs Milt Pappas | Sixth | 5 out |
| Saturday, June 2 |
| » Defeated Orioles (22-25), 10-2 | Memorial Stadium (2-0) | 25-24 | Won 2 |
| » Starters: Juan Pizarro vs Steve Barber | Sixth | 4½ out |
| » Lost to Orioles (23-25), 11-4 | Memorial Stadium (2-1) | 25-25 | |
| » Starters: Early Wynn vs Jack Fisher | Sixth | 4½ out |
| Sunday, June 3 |
| » Defeated Orioles (23-26), 2-0 | Memorial Stadium (3-1) | 26-25 | |
| » Starters: John Buzhardt vs Chuck Estrada | Fifth | 3½ out |
| Tuesday, June 5 |
| » Defeated Angels (25-23), 9-5 | Dodger Stadium (3-1) | 27-25 | Won 2 |
| » Starters: Joe Horlen vs Bo Belinsky | Fifth | 3 out |
| Wednesday, June 6 |
| » Lost to Angels (26-23), 1-0 | Dodger Stadium (3-2) | 27-26 | |
| » Starters: Ray Herbert vs Ken McBride | Sixth | 4 out |
| Thursday, June 7 |
| » Defeated Angels (26-24), 8-4 | Dodger Stadium (4-2) | 28-26 | |
| » Starters: Juan Pizarro vs Eli Grba | Sixth | 4 out |
| Friday, June 8 |
| » Lost to Twins (32-23), 2-1 | Metropolitan Stadium (3-1) | 28-27 | |
| » Starters: John Buzhardt vs Jack Kralick | Sixth | 5 out |
| Saturday, June 9 |
| » Defeated Twins (32-24), 8-5 | Metropolitan Stadium (4-1) | 29-27 | |
| » Starters: Early Wynn vs Jim Donohue | Fifth | 5 out |
| Sunday, June 10 |
| » Lost to Twins (33-24), 8-4 | Metropolitan Stadium (4-2) | 29-28 | |
| » Starters: Joe Horlen vs Jim Kaat | Sixth | 5 out |
| » Lost to Twins (34-24), 11-7 | Metropolitan Stadium (4-3) | 29-29 | Lost 2 |
| » Starters: Ray Herbert vs Camilo Pascual | Sixth | 5 out |
| Tuesday, June 12 |
| » Lost to Athletics (26-33), 2-1 | Municipal Stadium (2-2) | 29-30 | Lost 3 |
| » Starters: Juan Pizarro vs Dave Wickersham | Sixth | 5½ out |
| Wednesday, June 13 |
| » Lost to Athletics (27-33), 4-3 | Municipal Stadium (2-3) | 29-31 | Lost 4 |
| » Starters: John Buzhardt vs Ed Rakow | Sixth | 6 out |
| Thursday, June 14 |
| » Lost to Athletics (28-33), 11-8 | Municipal Stadium (2-4) | 29-32 | Lost 5 |
| » Starters: Joe Horlen vs John Wyatt | Seventh | 6½ out |
| Friday, June 15 |
| » Defeated Angels (31-27), 7-6 | Comiskey Park I (11-15) | 30-32 | |
| » Starters: Ken McBride vs Early Wynn | Seventh | 5½ out |
| Saturday, June 16 |
| » Defeated Angels (31-28), 4-3 | Comiskey Park I (12-15) | 31-32 | Won 2 |
| » Starters: Don Lee vs Ray Herbert | Sixth | 5½ out |
| Sunday, June 17 |
| » Lost to Angels (32-28), 5-3 | Comiskey Park I (12-16) | 31-33 | |
| » Starters: Dean Chance vs John Buzhardt | Eighth | 7½ out |
| » Lost to Angels (33-28), 6-5 | Comiskey Park I (12-17) | 31-34 | Lost 2 |
| » Starters: Eli Grba vs Joe Horlen | Eighth | 7½ out |
| Tuesday, June 19 |
| » Lost to Twins (38-28), 9-4 | Comiskey Park I (12-18) | 31-35 | Lost 3 |
| » Starters: Jim Kaat vs Juan Pizarro | Seventh | 7½ out |
| Wednesday, June 20 |
| » Defeated Twins (38-29), 5-1 | Comiskey Park I (13-18) | 32-35 | |
| » Starters: Joe Bonikowski vs Ray Herbert | Seventh | 8 out |
| Thursday, June 21 |
| » Defeated Twins (38-30), 6-2 | Comiskey Park I (14-18) | 33-35 | Won 2 |
| » Starters: Jack Kralick vs John Buzhardt | Seventh | 7 out |
| Friday, June 22 |
| » Defeated Athletics (31-38), 5-1 | Comiskey Park I (15-18) | 34-35 | Won 3 |
| » Starters: Dan Pfister vs Joe Horlen | Seventh | 7 out |
| Saturday, June 23 |
| » Defeated Athletics (31-39), 6-1 | Comiskey Park I (16-18) | 35-35 | Won 4 |
| » Starters: Ed Rakow vs Juan Pizarro | Seventh | 6 out |
| Sunday, June 24 |
| » Defeated Athletics (31-40), 6-1 | Comiskey Park I (17-18) | 36-35 | Won 5 |
| » Starters: Jerry Walker vs Ray Herbert | Seventh | 6 out |
| » Lost to Athletics (32-40), 5-2 | Comiskey Park I (17-19) | 36-36 | |
| » Starters: Diego Segui vs Early Wynn | Seventh | 6 out |
| Tuesday, June 26 |
| » Lost to Orioles (36-35), 1-0 | Memorial Stadium (3-2) | 36-37 | Lost 2 |
| » Starters: John Buzhardt vs Milt Pappas | Seventh | 6½ out |
| Wednesday, June 27 |
| » Lost to Orioles (37-35), 3-1 | Memorial Stadium (3-3) | 36-38 | Lost 3 |
| » Starters: Juan Pizarro vs Robin Roberts | Seventh | 6½ out |
| Thursday, June 28 |
| » Lost to Orioles (38-35), 6-0 | Memorial Stadium (3-4) | 36-39 | Lost 4 |
| » Starters: Dom Zanni vs Steve Barber | Seventh | 7 out |
| Friday, June 29 |
| » Defeated Indians (41-31), 3-2 | Comiskey Park I (18-19) | 37-39 | |
| » Starters: Jim Perry vs Ray Herbert | Seventh | 6 out |
| Saturday, June 30 |
| » Defeated Indians (41-32), 7-0 | Comiskey Park I (19-19) | 38-39 | Won 2 |
| » Starters: Mudcat Grant vs Early Wynn | Seventh | 5 out |
| Sunday, July 1 |
| » Defeated Indians (41-33), 5-4 | Comiskey Park I (20-19) | 39-39 | Won 3 |
| » Starters: Pedro Ramos vs John Buzhardt | Sixth | 3½ out |
| » Defeated Indians (41-34), 7-6 | Comiskey Park I (21-19) | 40-39 | Won 4 |
| » Starters: Bob Hartman vs Juan Pizarro | Sixth | 3½ out |
| Monday, July 2 |
| » Lost to Tigers (39-36), 2-1 | Tiger Stadium (1-3) | 40-40 | |
| » Starters: Frank Baumann vs Sam Jones | Seventh | 4½ out |
| Tuesday, July 3 |
| » Lost to Tigers (40-36), 5-4 | Tiger Stadium (1-4) | 40-41 | Lost 2 |
| » Starters: Eddie Fisher vs Paul Foytack | Seventh | 5½ out |
| Wednesday, July 4 |
| » Lost to Orioles (40-39), 7-3 | Comiskey Park I (21-20) | 40-42 | Lost 3 |
| » Starters: Milt Pappas vs Ray Herbert | Seventh | 6 out |
| » Defeated Orioles (40-40), 5-2 | Comiskey Park I (22-20) | 41-42 | |
| » Starters: Chuck Estrada vs Juan Pizarro | Seventh | 6 out |
| Thursday, July 5 |
| » Lost to Orioles (41-40), 5-4 | Comiskey Park I (22-21) | 41-43 | |
| » Starters: Jack Fisher vs Frank Baumann | Sixth | 6½ out |
| Friday, July 6 |
| » Lost to Indians (46-34), 5-3 | Cleveland Stadium (1-1) | 41-44 | Lost 2 |
| » Starters: Early Wynn vs Ruben Gomez | Seventh | 7½ out |
| Saturday, July 7 |
| » Lost to Indians (47-34), 5-3 | Cleveland Stadium (1-2) | 41-45 | Lost 3 |
| » Starters: Eddie Fisher vs Dick Donovan | Seventh | 8½ out |
| Sunday, July 8 |
| » Defeated Indians (47-35), 6-3 | Cleveland Stadium (2-2) | 42-45 | |
| » Starters: Juan Pizarro vs Jim Perry | Seventh | 7½ out |
| » Defeated Indians (47-36), 8-4 | Cleveland Stadium (3-2) | 43-45 | Won 2 |
| » Starters: Ray Herbert vs Pedro Ramos | Seventh | 7½ out |
| Thursday, July 12 |
| » Defeated Tigers (43-41), 3-2 | Comiskey Park I (23-21) | 44-45 | Won 3 |
| » Starters: Don Mossi vs Juan Pizarro | Sixth | 6½ out |
| Friday, July 13 |
| » Defeated Tigers (43-42), 4-1 | Comiskey Park I (24-21) | 45-45 | Won 4 |
| » Starters: Paul Foytack vs Ray Herbert | Sixth | 5½ out |
| Saturday, July 14 |
| » Defeated Tigers (43-43), 4-2 | Comiskey Park I (25-21) | 46-45 | Won 5 |
| » Starters: Jim Bunning vs Frank Baumann | Fifth | 5½ out |
| Sunday, July 15 |
| » Defeated Tigers (43-44), 5-3 | Comiskey Park I (26-21) | 47-45 | Won 6 |
| » Starters: Sam Jones vs Eddie Fisher | Fifth | 6 out |
| Tuesday, July 17 |
| » Lost to Senators (31-56), 1-0 | Comiskey Park I (26-22) | 47-46 | |
| » Starters: Dave Stenhouse vs Juan Pizarro | Sixth | 8 out |
| » Lost to Senators (32-56), 7-3 | Comiskey Park I (26-23) | 47-47 | Lost 2 |
| » Starters: Tom Cheney vs Early Wynn | Sixth | 8 out |
| » Major-league debuts: Ramon Conde (White Sox) Don Lock (Senators) |
| Wednesday, July 18 |
| » Lost to Senators (33-56), 1-0 | Comiskey Park I (26-24) | 47-48 | Lost 3 |
| » Starters: Bennie Daniels vs Ray Herbert | Sixth | 9 out |
| Friday, July 20 |
| » Lost to Red Sox (44-48), 8-4 | Fenway Park (1-4) | 47-49 | Lost 4 |
| » Starters: John Buzhardt vs Don Schwall | Sixth | 10½ out |
| Saturday, July 21 |
| » Defeated Red Sox (44-49), 5-0 | Fenway Park (2-4) | 48-49 | |
| » Starters: Juan Pizarro vs Gene Conley | Sixth | 10½ out |
| Sunday, July 22 |
| » Defeated Red Sox (44-50), 7-3 | Fenway Park (3-4) | 49-49 | Won 2 |
| » Starters: Ray Herbert vs Bill Monbouquette | Sixth | 9 out |
| Tuesday, July 24 |
| » Defeated Senators (35-59), 6-0 | Robert F. Kennedy Stadium (3-1) | 50-49 | Won 3 |
| » Starters: Early Wynn vs Tom Cheney | Fifth | 9 out |
| Wednesday, July 25 |
| » Lost to Senators (36-59), 4-3 | Robert F. Kennedy Stadium (3-2) | 50-50 | |
| » Starters: Juan Pizarro vs Claude Osteen | Fifth | 9½ out |
| Future White Sox Doug Drabek is born in Victoria, TX. |
| Thursday, July 26 |
| » Defeated Senators (36-60), 7-1 | Robert F. Kennedy Stadium (4-2) | 51-50 | |
| » Starters: Ray Herbert vs Bennie Daniels | Fifth | 9½ out |
| Friday, July 27 |
| » Lost to Yankees (59-38), 4-3 | Yankee Stadium (1-2) | 51-51 | |
| » Starters: Frank Baumann vs Bill Stafford | Sixth | 10½ out |
| Saturday, July 28 |
| » Lost to Yankees (60-38), 4-3 | Yankee Stadium (1-3) | 51-52 | Lost 2 |
| » Starters: Eddie Fisher vs Whitey Ford | Sixth | 11½ out |
| Sunday, July 29 |
| » Lost to Yankees (61-38), 7-4 | Yankee Stadium (1-4) | 51-53 | Lost 3 |
| » Starters: Juan Pizarro vs Ralph Terry | Sixth | 11½ out |
| » Defeated Yankees (61-39), 6-2 | Yankee Stadium (2-4) | 52-53 | |
| » Starters: Mike Joyce vs Rollie Sheldon | Sixth | 11½ out |
| Wednesday, August 1 |
| » Lost to Red Sox (47-56), 1-0 | Comiskey Park I (26-25) | 52-54 | |
| » Starters: Bill Monbouquette vs Early Wynn | Seventh | 13½ out |
| Thursday, August 2 |
| » Lost to Red Sox (48-56), 7-4 | Comiskey Park I (26-26) | 52-55 | Lost 2 |
| » Starters: Don Schwall vs Ray Herbert | Seventh | 14 out |
| Friday, August 3 |
| » Lost to Yankees (65-39), 10-2 | Comiskey Park I (26-27) | 52-56 | Lost 3 |
| » Starters: Ralph Terry vs Juan Pizarro | Sixth | 15 out |
| Saturday, August 4 |
| » Defeated Yankees (65-40), 2-1 | Comiskey Park I (27-27) | 53-56 | |
| » Starters: Bill Stafford vs Frank Baumann | Seventh | 14 out |
| Sunday, August 5 |
| » Defeated Yankees (65-41), 3-2 | Comiskey Park I (28-27) | 54-56 | Won 2 |
| » Starters: Whitey Ford vs Eddie Fisher | Sixth | 13 out |
| Monday, August 6 |
| » Defeated Orioles (57-54), 5-4 | Comiskey Park I (29-27) | 55-56 | Won 3 |
| » Starters: Chuck Estrada vs Early Wynn | Sixth | 12 out |
| Tuesday, August 7 |
| » Defeated Orioles (57-55), 4-0 | Comiskey Park I (30-27) | 56-56 | Won 4 |
| » Starters: Dick Hall vs Ray Herbert | Sixth | 12 out |
| Wednesday, August 8 |
| » Lost to Angels (63-49), 5-1 | Comiskey Park I (30-28) | 56-57 | |
| » Starters: Ted Bowsfield vs Juan Pizarro | Sixth | 13 out |
| » Lost to Angels (64-49), 7-5 | Comiskey Park I (30-29) | 56-58 | Lost 2 |
| » Starters: Don Lee vs Frank Baumann | Sixth | 13 out |
| Thursday, August 9 |
| » Defeated Angels (64-50), 6-0 | Comiskey Park I (31-29) | 57-58 | |
| » Starters: Eli Grba vs Eddie Fisher | Fourth | 12½ out |
| Friday, August 10 |
| » Defeated Athletics (52-64), 3-1 | Municipal Stadium (3-4) | 58-58 | Won 2 |
| » Starters: Early Wynn vs Orlando Pena | Fifth | 12½ out |
| Saturday, August 11 |
| » Defeated Athletics (52-65), 11-2 | Municipal Stadium (4-4) | 59-58 | Won 3 |
| » Starters: John Buzhardt vs Ed Rakow | Fourth | 12 out |
| Sunday, August 12 |
| » Defeated Athletics (52-66), 1-0 | Municipal Stadium (5-4) | 60-58 | Won 4 |
| » Starters: Ray Herbert vs Bill Fischer | Fourth | 12 out |
| Tuesday, August 14 |
| » Defeated Indians (57-61), 9-0 | Cleveland Stadium (4-2) | 61-58 | Won 5 |
| » Starters: Frank Baumann vs Pedro Ramos | Fourth | 11½ out |
| Wednesday, August 15 |
| » Defeated Indians (57-62), 10-2 | Cleveland Stadium (5-2) | 62-58 | Won 6 |
| » Starters: Juan Pizarro vs Sam McDowell | Fourth | 12 out |
| » Lost to Indians (58-62), 3-2 | Cleveland Stadium (5-3) | 62-59 | |
| » Starters: Early Wynn vs Jim Perry | Fourth | 12 out |
| Thursday, August 16 |
| » Defeated Indians (58-63), 11-6 | Cleveland Stadium (6-3) | 63-59 | |
| » Starters: Eddie Fisher vs Mudcat Grant | Fourth | 11 out |
| Friday, August 17 |
| » Lost to Tigers (60-60), 2-0 | Comiskey Park I (31-30) | 63-60 | |
| » Starters: Jim Bunning vs John Buzhardt | Fourth | 11 out |
| Saturday, August 18 |
| » Defeated Tigers (60-61), 2-0 | Comiskey Park I (32-30) | 64-60 | |
| » Starters: Ron Kline vs Ray Herbert | Fourth | 10½ out |
| Sunday, August 19 |
| » Defeated Tigers (60-62), 11-5 | Comiskey Park I (33-30) | 65-60 | Won 2 |
| » Starters: Phil Regan vs Frank Baumann | Fourth | 11 out |
| » Lost to Tigers (61-62), 8-3 | Comiskey Park I (33-31) | 65-61 | |
| » Starters: Howie Koplitz vs Juan Pizarro | Fourth | 11 out |
| Tuesday, August 21 |
| » Lost to Orioles (61-63), 9-1 | Memorial Stadium (3-5) | 65-62 | Lost 2 |
| » Starters: Early Wynn vs Robin Roberts | Fourth | 11½ out |
| Wednesday, August 22 |
| » Defeated Orioles (61-64), 7-6 | Memorial Stadium (4-5) | 66-62 | |
| » Starters: John Buzhardt vs Milt Pappas | Fourth | 11½ out |
| Future White Sox Darrin Jackson is born in Los Angeles, CA. |
| Friday, August 24 |
| » Defeated Angels (72-57), 7-1 | Dodger Stadium (5-2) | 67-62 | Won 2 |
| » Starters: Ray Herbert vs Ted Bowsfield | Fourth | 9½ out |
| Saturday, August 25 |
| » Defeated Angels (72-58), 9-2 | Dodger Stadium (6-2) | 68-62 | Won 3 |
| » Starters: Eddie Fisher vs Bo Belinsky | Fourth | 8 out |
| Sunday, August 26 |
| » Lost to Angels (73-58), 4-0 | Dodger Stadium (6-3) | 68-63 | |
| » Starters: Frank Baumann vs Don Lee | Fourth | 8 out |
| Tuesday, August 28 |
| » Lost to Twins (75-59), 2-0 | Comiskey Park I (33-32) | 68-64 | Lost 2 |
| » Starters: Jim Kaat vs Early Wynn | Fourth | 9½ out |
| Wednesday, August 29 |
| » Lost to Twins (76-59), 5-3 | Comiskey Park I (33-33) | 68-65 | Lost 3 |
| » Starters: Camilo Pascual vs Ray Herbert | Fourth | 9 out |
| Thursday, August 30 |
| » Defeated Tigers (66-66), 5-4 | Tiger Stadium (2-4) | 69-65 | |
| » Starters: Frank Baumann vs Phil Regan | Fourth | 8½ out |
| Friday, August 31 |
| » Lost to Tigers (67-66), 5-2 | Tiger Stadium (2-5) | 69-66 | |
| » Starters: John Buzhardt vs Jim Bunning | Fourth | 9½ out |
| Saturday, September 1 |
| » Lost to Tigers (68-66), 2-1 | Tiger Stadium (2-6) | 69-67 | Lost 2 |
| » Starters: Ray Herbert vs Hank Aguirre | Fourth | 10½ out |
| Sunday, September 2 |
| » Defeated Tigers (68-67), 10-8 | Tiger Stadium (3-6) | 70-67 | |
| » Starters: Eddie Fisher vs Paul Foytack | Fourth | 10½ out |
| » Major-league debuts: Frank Kostro (Tigers) |
| Monday, September 3 |
| » Lost to Indians (67-73), 4-3 | Comiskey Park I (33-34) | 70-68 | |
| » Starters: Pedro Ramos vs Early Wynn | Fifth | 11½ out |
| » Lost to Indians (68-73), 6-5 | Comiskey Park I (33-35) | 70-69 | Lost 2 |
| » Starters: Barry Latman vs Joe Horlen | Fifth | 11½ out |
| Tuesday, September 4 |
| » Defeated Indians (68-74), 3-2 | Comiskey Park I (34-35) | 71-69 | |
| » Starters: Dick Donovan vs John Buzhardt | Fifth | 10½ out |
| Wednesday, September 5 |
| » Defeated Indians (68-75), 2-1 | Comiskey Park I (35-35) | 72-69 | Won 2 |
| » Starters: Mudcat Grant vs Ray Herbert | Fifth | 10 out |
| Friday, September 7 |
| » Lost to Senators (56-88), 7-2 | Comiskey Park I (35-36) | 72-70 | |
| » Starters: Tom Cheney vs Eddie Fisher | Fifth | 11½ out |
| Saturday, September 8 |
| » Defeated Senators (56-89), 6-3 | Comiskey Park I (36-36) | 73-70 | |
| » Starters: Don Rudolph vs Early Wynn | Fifth | 11½ out |
| » Major-league debuts: Deacon Jones (White Sox) |
| Sunday, September 9 |
| » Defeated Senators (56-90), 4-3 | Comiskey Park I (37-36) | 74-70 | Won 2 |
| » Starters: Dave Stenhouse vs Joe Horlen | Fourth | 9½ out |
| » Defeated Senators (56-91), 3-2 | Comiskey Park I (38-36) | 75-70 | Won 3 |
| » Starters: Bob Baird vs John Buzhardt | Fourth | 9½ out |
| » Major-league debuts: Ken Berry (White Sox) |
| Monday, September 10 |
| » Defeated Athletics (63-82), 4-3 | Comiskey Park I (39-36) | 76-70 | Won 4 |
| » Starters: Bill Fischer vs Ray Herbert | Fourth | 9½ out |
| Tuesday, September 11 |
| » Major-league debuts: Max Alvis (Indians) |
| Wednesday, September 12 |
| » Defeated Twins (82-66), 2-1 | Metropolitan Stadium (5-3) | 77-70 | Won 5 |
| » Starters: Eddie Fisher vs Camilo Pascual | Fourth | 10 out |
| Thursday, September 13 |
| » Lost to Twins (83-66), 5-1 | Metropolitan Stadium (5-4) | 77-71 | |
| » Starters: John Buzhardt vs Jack Kralick | Fourth | 10½ out |
| Friday, September 14 |
| » Defeated Senators (57-94), 2-0 | Robert F. Kennedy Stadium (5-2) | 78-71 | |
| » Starters: Joe Horlen vs Dave Stenhouse | Fourth | 9½ out |
| Saturday, September 15 |
| » Lost to Senators (58-94), 3-1 | Robert F. Kennedy Stadium (5-3) | 78-72 | |
| » Starters: Juan Pizarro vs Carl Bouldin | Fourth | 10½ out |
| » Major-league debuts: Al Weis (White Sox) |
| Sunday, September 16 |
| » Defeated Senators (58-95), 7-4 | Robert F. Kennedy Stadium (6-3) | 79-72 | |
| » Starters: Ray Herbert vs Claude Osteen | Fourth | 9½ out |
| Former White Sox Paul Gregory dies at the age of 55. |
| Monday, September 17 |
| » Major-league debuts: Ken McMullen (Dodgers) |
| Tuesday, September 18 |
| » Lost to Red Sox (73-79), 10-5 | Comiskey Park I (39-37) | 79-73 | |
| » Starters: Don Schwall vs Early Wynn | Fourth | 10½ out |
| Wednesday, September 19 |
| » Defeated Red Sox (73-80), 3-2 | Comiskey Park I (40-37) | 80-73 | |
| » Starters: Bill Monbouquette vs Eddie Fisher | Fourth | 10½ out |
| Thursday, September 20 |
| » Defeated Red Sox (73-81), 6-4 | Comiskey Park I (41-37) | 81-73 | Won 2 |
| » Starters: Earl Wilson vs Joe Horlen | Fourth | 10 out |
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