| Saturday, February 3 |
| Future Twin Joe Klink is born in Johnstown, PA. |
| Monday, February 19 |
| Future Twin Alvaro Espinoza is born in Valencia, Venezuela. |
| Friday, March 2 |
| Future Twin Terry Steinbach is born in New Ulm, MN. |
| Thursday, March 29 |
| Future Twin Billy Beane is born in Orlando, FL. |
| Tuesday, April 10 |
| » Lost to Athletics (1-0), 4-2 | Municipal Stadium (0-1) | 0-1 | |
| » Starters: Jack Kralick vs Ed Rakow | Second | 1 out |
| » Major-league debuts: Bernie Allen (Twins) |
| Wednesday, April 11 |
| » Defeated Athletics (1-1), 8-0 | Municipal Stadium (1-1) | 1-1 | |
| » Starters: Camilo Pascual vs John Wyatt | Second | ½ out |
| Thursday, April 12 |
| » Defeated Athletics (1-2), 9-5 | Municipal Stadium (2-1) | 2-1 | Won 2 |
| » Starters: Don Lee vs Norm Bass | Second | 1 out |
| » Major-league debuts: Diego Segui (Athletics) |
| Friday, April 13 |
| Future Twin Jeff Bittiger is born in Jersey City, NJ. |
| Saturday, April 14 |
| » Lost to Angels (2-1), 12-5 | Metropolitan Stadium (0-1) | 2-2 | |
| » Starters: George Witt vs Jim Kaat | Third | ½ out |
| Sunday, April 15 |
| » Lost to Angels (3-1), 6-3 | Metropolitan Stadium (0-2) | 2-3 | Lost 2 |
| » Starters: Eli Grba vs Jack Kralick | Fifth | 1½ out |
| » Major-league debuts: George Banks (Twins) |
| Monday, April 16 |
| » Major-league debuts: Hank Fischer (Braves) |
| Tuesday, April 17 |
| » Lost to White Sox (4-2), 8-0 | Metropolitan Stadium (0-3) | 2-4 | Lost 3 |
| » Starters: Joe Horlen vs Camilo Pascual | Seventh | 2 out |
| Wednesday, April 18 |
| » Lost to White Sox (5-2), 3-2 | Metropolitan Stadium (0-4) | 2-5 | Lost 4 |
| » Starters: Ray Herbert vs Don Lee | Eighth | 3 out |
| Thursday, April 19 |
| » Lost to White Sox (6-2), 10-3 | Metropolitan Stadium (0-5) | 2-6 | Lost 5 |
| » Starters: John Buzhardt vs Jim Kaat | Ninth | 4 out |
| Friday, April 20 |
| » Defeated Angels (5-3), 9-7 | Dodger Stadium (1-0) | 3-6 | |
| » Starters: Jack Kralick vs Eli Grba | Tenth | 3 out |
| Saturday, April 21 |
| » Defeated Angels (5-4), 5-2 | Dodger Stadium (2-0) | 4-6 | Won 2 |
| » Starters: Camilo Pascual vs Ken McBride | Eighth | 2½ out |
| Sunday, April 22 |
| » Defeated Angels (5-5), 5-0 | Dodger Stadium (3-0) | 5-6 | Won 3 |
| » Starters: Jim Kaat vs George Witt | Eighth | 1½ out |
| Tuesday, April 24 |
| » Lost to Orioles (7-4), 5-4 | Memorial Stadium (0-1) | 5-7 | |
| » Starters: Jack Kralick vs Milt Pappas | Eighth | 2½ out |
| Wednesday, April 25 |
| » Defeated Orioles (7-5), 3-1 | Memorial Stadium (1-1) | 6-7 | |
| » Starters: Don Lee vs Chuck Estrada | Eighth | 1½ out |
| Thursday, April 26 |
| » Defeated Orioles (7-6), 3-2 | Memorial Stadium (2-1) | 7-7 | Won 2 |
| » Starters: Camilo Pascual vs Hal Brown | Fifth | 1½ out |
| Friday, April 27 |
| » Lost to Indians (8-4), 7-2 | Cleveland Stadium (0-1) | 7-8 | |
| » Starters: Jim Kaat vs Dick Donovan | Seventh | 2½ out |
| Saturday, April 28 |
| » Lost to Indians (9-4), 8-7 | Cleveland Stadium (0-2) | 7-9 | Lost 2 |
| » Starters: Jim Manning vs Ron Taylor | Ninth | 3½ out |
| Sunday, April 29 |
| » Defeated Indians (9-5), 8-4 | Cleveland Stadium (1-2) | 8-9 | |
| » Starters: Jack Kralick vs Pedro Ramos | Sixth | 2½ out |
| » Defeated Indians (9-6), 7-3 | Cleveland Stadium (2-2) | 9-9 | Won 2 |
| » Starters: Don Lee vs Gary Bell | Sixth | 2½ out |
| Tuesday, May 1 |
| » Defeated Orioles (9-8), 8-3 | Metropolitan Stadium (1-5) | 10-9 | Won 3 |
| » Starters: Chuck Estrada vs Camilo Pascual | Sixth | 2½ out |
| Wednesday, May 2 |
| » Lost to Orioles (10-8), 6-5 | Metropolitan Stadium (1-6) | 10-10 | |
| » Starters: Hal Brown vs Jim Kaat | Fifth | 3½ out |
| » Major-league debuts: Marty Martinez (Twins) |
| Thursday, May 3 |
| » Defeated Orioles (10-9), 8-4 | Metropolitan Stadium (2-6) | 11-10 | |
| » Starters: Milt Pappas vs Jack Kralick | Sixth | 2½ out |
| Friday, May 4 |
| » Defeated Tigers (9-9), 4-2 | Metropolitan Stadium (3-6) | 12-10 | Won 2 |
| » Starters: Phil Regan vs Don Lee | Third | 2 out |
| Saturday, May 5 |
| » Defeated Tigers (9-10), 7-2 | Metropolitan Stadium (4-6) | 13-10 | Won 3 |
| » Starters: Jim Bunning vs Lee Stange | Third | 2 out |
| Sunday, May 6 |
| » Defeated Tigers (9-11), 10-7 | Metropolitan Stadium (5-6) | 14-10 | Won 4 |
| » Starters: Paul Foytack vs Camilo Pascual | Third | 1½ out |
| Tuesday, May 8 |
| » Lost to Indians (13-8), 6-3 | Metropolitan Stadium (5-7) | 14-11 | |
| » Starters: Dick Donovan vs Jim Kaat | Third | 2 out |
| Wednesday, May 9 |
| » Defeated Indians (13-9), 2-1 | Metropolitan Stadium (6-7) | 15-11 | |
| » Starters: Gary Bell vs Jack Kralick | Third | 2 out |
| Thursday, May 10 |
| » Lost to Indians (14-9), 9-4 | Metropolitan Stadium (6-8) | 15-12 | |
| » Starters: Jim Perry vs Don Lee | Third | 2½ out |
| Friday, May 11 |
| » Lost to Athletics (13-16), 5-3 | Metropolitan Stadium (6-9) | 15-13 | Lost 2 |
| » Starters: Dan Pfister vs Camilo Pascual | Fourth | 2½ out |
| Saturday, May 12 |
| » Defeated Athletics (13-17), 5-4 | Metropolitan Stadium (7-9) | 16-13 | |
| » Starters: Art Ditmar vs Lee Stange | Third | 2½ out |
| Sunday, May 13 |
| » Defeated Athletics (13-18), 10-3 | Metropolitan Stadium (8-9) | 17-13 | Won 2 |
| » Starters: Norm Bass vs Joe Bonikowski | Third | 1½ out |
| Tuesday, May 15 |
| » Defeated Tigers (13-14), 4-2 | Tiger Stadium (1-0) | 18-13 | Won 3 |
| » Starters: Jack Kralick vs Frank Lary | Third | 1½ out |
| Wednesday, May 16 |
| » Defeated Tigers (13-15), 8-4 | Tiger Stadium (2-0) | 19-13 | Won 4 |
| » Starters: Camilo Pascual vs Jim Bunning | Third | 1½ out |
| Friday, May 18 |
| » Defeated Yankees (18-12), 4-3 | Yankee Stadium (1-0) | 20-13 | Won 5 |
| » Starters: Don Lee vs Whitey Ford | Second | 1½ out |
| Saturday, May 19 |
| » Lost to Yankees (19-12), 2-1 | Yankee Stadium (1-1) | 20-14 | |
| » Starters: Joe Bonikowski vs Ralph Terry | Second | 1½ out |
| Sunday, May 20 |
| » Lost to Yankees (20-12), 4-3 | Yankee Stadium (1-2) | 20-15 | Lost 2 |
| » Starters: Jack Kralick vs Bill Stafford | Second | 1½ out |
| » Defeated Yankees (20-13), 4-2 | Yankee Stadium (2-2) | 21-15 | |
| » Starters: Jim Kaat vs Rollie Sheldon | Second | 1½ out |
| Monday, May 21 |
| » Defeated Senators (9-24), 5-3 | Robert F. Kennedy Stadium (1-0) | 22-15 | Won 2 |
| » Starters: Camilo Pascual vs Dave Stenhouse | Third | 1½ out |
| Tuesday, May 22 |
| » Defeated Senators (9-25), 6-5 | Robert F. Kennedy Stadium (2-0) | 23-15 | Won 3 |
| » Starters: Georges Maranda vs Joe McClain | Second | 2 out |
| Wednesday, May 23 |
| » Lost to Red Sox (14-22), 6-1 | Fenway Park (0-1) | 23-16 | |
| » Starters: Don Lee vs Earl Wilson | Third | 2 out |
| Thursday, May 24 |
| » Lost to Red Sox (15-22), 7-5 | Fenway Park (0-2) | 23-17 | Lost 2 |
| » Starters: Joe Bonikowski vs Don Schwall | Third | 2 out |
| Friday, May 25 |
| » Lost to White Sox (21-19), 5-4 | Comiskey Park I (0-1) | 23-18 | Lost 3 |
| » Starters: Jack Kralick vs Joe Horlen | Second | 2 out |
| Saturday, May 26 |
| » Defeated White Sox (21-20), 4-1 | Comiskey Park I (1-1) | 24-18 | |
| » Starters: Camilo Pascual vs John Buzhardt | Second | 2 out |
| Sunday, May 27 |
| » Defeated White Sox (21-21), 5-4 | Comiskey Park I (2-1) | 25-18 | Won 2 |
| » Starters: Jim Kaat vs Ray Herbert | Third | 2½ out |
| » Defeated White Sox (21-22), 8-6 | Comiskey Park I (3-1) | 26-18 | Won 3 |
| » Starters: Don Lee vs Juan Pizarro | Third | 2½ out |
| Monday, May 28 |
| » Lost to Red Sox (17-24), 3-0 | Metropolitan Stadium (8-10) | 26-19 | |
| » Starters: Earl Wilson vs Jack Kralick | Second | 2½ out |
| Tuesday, May 29 |
| » Lost to Red Sox (18-24), 8-5 | Metropolitan Stadium (8-11) | 26-20 | Lost 2 |
| » Starters: Don Schwall vs Lee Stange | Third | 3 out |
| Wednesday, May 30 |
| » Lost to Yankees (25-17), 10-1 | Metropolitan Stadium (8-12) | 26-21 | Lost 3 |
| » Starters: Bill Stafford vs Joe Bonikowski | Third | 3 out |
| » Defeated Yankees (25-18), 5-4 | Metropolitan Stadium (9-12) | 27-21 | |
| » Starters: Rollie Sheldon vs Camilo Pascual | Third | 3 out |
| Friday, June 1 |
| » Lost to Senators (14-31), 4-3 | Metropolitan Stadium (9-13) | 27-22 | |
| » Starters: Dave Stenhouse vs Jim Kaat | Third | 2½ out |
| Saturday, June 2 |
| » Defeated Senators (14-32), 9-2 | Metropolitan Stadium (10-13) | 28-22 | |
| » Starters: Pete Burnside vs Joe Bonikowski | Third | 2½ out |
| Sunday, June 3 |
| » Defeated Senators (14-33), 7-5 | Metropolitan Stadium (11-13) | 29-22 | Won 2 |
| » Starters: Bennie Daniels vs Jack Kralick | Second | 2½ out |
| Tuesday, June 5 |
| » Lost to Athletics (25-27), 4-3 | Metropolitan Stadium (11-14) | 29-23 | |
| » Starters: John Wyatt vs Camilo Pascual | Third | 3 out |
| Wednesday, June 6 |
| » Defeated Athletics (25-28), 7-0 | Metropolitan Stadium (12-14) | 30-23 | |
| » Starters: Jerry Walker vs Jim Kaat | Third | 3 out |
| Thursday, June 7 |
| » Defeated Athletics (25-29), 5-2 | Metropolitan Stadium (13-14) | 31-23 | Won 2 |
| » Starters: Dave Wickersham vs Joe Bonikowski | Second | 3 out |
| Friday, June 8 |
| » Defeated White Sox (28-27), 2-1 | Metropolitan Stadium (14-14) | 32-23 | Won 3 |
| » Starters: John Buzhardt vs Jack Kralick | Second | 3 out |
| Saturday, June 9 |
| » Lost to White Sox (29-27), 8-5 | Metropolitan Stadium (14-15) | 32-24 | |
| » Starters: Early Wynn vs Jim Donohue | Third | 3 out |
| Sunday, June 10 |
| » Defeated White Sox (29-28), 8-4 | Metropolitan Stadium (15-15) | 33-24 | |
| » Starters: Joe Horlen vs Jim Kaat | Second | 3 out |
| » Defeated White Sox (29-29), 11-7 | Metropolitan Stadium (16-15) | 34-24 | Won 2 |
| » Starters: Ray Herbert vs Camilo Pascual | Second | 3 out |
| Tuesday, June 12 |
| » Lost to Angels (31-24), 7-5 | Dodger Stadium (3-1) | 34-25 | |
| » Starters: Joe Bonikowski vs Don Lee | Third | 2½ out |
| Wednesday, June 13 |
| » Defeated Angels (31-25), 4-2 | Dodger Stadium (4-1) | 35-25 | |
| » Starters: Jack Kralick vs Dean Chance | Second | 3 out |
| Thursday, June 14 |
| » Defeated Angels (31-26), 5-4 | Dodger Stadium (5-1) | 36-25 | Won 2 |
| » Starters: Jim Kaat vs Bo Belinsky | Second | 3½ out |
| Friday, June 15 |
| » Lost to Athletics (29-33), 6-1 | Municipal Stadium (2-2) | 36-26 | |
| » Starters: Camilo Pascual vs Jerry Walker | Second | 3½ out |
| Saturday, June 16 |
| » Lost to Athletics (30-33), 6-2 | Municipal Stadium (2-3) | 36-27 | Lost 2 |
| » Starters: Joe Bonikowski vs Diego Segui | Second | 2½ out |
| Sunday, June 17 |
| » Lost to Athletics (31-33), 10-6 | Municipal Stadium (2-4) | 36-28 | Lost 3 |
| » Starters: Jack Kralick vs Dave Wickersham | Second | 2 out |
| Monday, June 18 |
| » Defeated Athletics (31-34), 9-4 | Municipal Stadium (3-4) | 37-28 | |
| » Starters: Camilo Pascual vs Ed Rakow | Second | 2½ out |
| Tuesday, June 19 |
| » Defeated White Sox (31-35), 9-4 | Comiskey Park I (4-1) | 38-28 | Won 2 |
| » Starters: Jim Kaat vs Juan Pizarro | Second | 2½ out |
| Wednesday, June 20 |
| » Lost to White Sox (32-35), 5-1 | Comiskey Park I (4-2) | 38-29 | |
| » Starters: Joe Bonikowski vs Ray Herbert | Second | 2 out |
| Thursday, June 21 |
| » Lost to White Sox (33-35), 6-2 | Comiskey Park I (4-3) | 38-30 | Lost 2 |
| » Starters: Jack Kralick vs John Buzhardt | Third | 2 out |
| Friday, June 22 |
| » Defeated Angels (36-29), 3-2 | Metropolitan Stadium (17-15) | 39-30 | |
| » Starters: Don Lee vs Georges Maranda | Second | 2½ out |
| » Defeated Angels (36-30), 8-3 | Metropolitan Stadium (18-15) | 40-30 | Won 2 |
| » Starters: Dean Chance vs Camilo Pascual | Second | 2½ out |
| Saturday, June 23 |
| » Defeated Angels (36-31), 5-0 | Metropolitan Stadium (19-15) | 41-30 | Won 3 |
| » Starters: Eli Grba vs Jim Kaat | Second | 2½ out |
| Sunday, June 24 |
| » Lost to Angels (37-31), 3-2 | Metropolitan Stadium (19-16) | 41-31 | |
| » Starters: Ken McBride vs Jack Kralick | Second | 2½ out |
| » Lost to Angels (38-31), 7-6 | Metropolitan Stadium (19-17) | 41-32 | Lost 2 |
| » Starters: Ted Bowsfield vs Joe Bonikowski | Second | 2½ out |
| Tuesday, June 26 |
| » Defeated Yankees (36-30), 5-0 | Yankee Stadium (3-2) | 42-32 | |
| » Starters: Camilo Pascual vs Rollie Sheldon | Second | 2 out |
| Wednesday, June 27 |
| » Lost to Yankees (37-30), 7-3 | Yankee Stadium (3-3) | 42-33 | |
| » Starters: Jim Kaat vs Ralph Terry | Second | 2 out |
| Thursday, June 28 |
| » Lost to Yankees (38-30), 4-2 | Yankee Stadium (3-4) | 42-34 | Lost 2 |
| » Starters: Jack Kralick vs Bill Stafford | Fourth | 2½ out |
| Friday, June 29 |
| » Lost to Senators (25-47), 6-3 | Robert F. Kennedy Stadium (2-1) | 42-35 | Lost 3 |
| » Starters: Joe Bonikowski vs Dave Stenhouse | Fourth | 2½ out |
| Saturday, June 30 |
| » Lost to Senators (26-47), 1-0 | Robert F. Kennedy Stadium (2-2) | 42-36 | Lost 4 |
| » Starters: Jim Kaat vs Tom Cheney | Fourth | 2½ out |
| Sunday, July 1 |
| » Defeated Senators (26-48), 9-0 | Robert F. Kennedy Stadium (3-2) | 43-36 | |
| » Starters: Camilo Pascual vs Ray Rippelmeyer | Fourth | 3½ out |
| Monday, July 2 |
| » Lost to Red Sox (36-41), 4-3 | Fenway Park (0-3) | 43-37 | |
| » Starters: Georges Maranda vs Ike Delock | Fourth | 3½ out |
| Tuesday, July 3 |
| » Defeated Red Sox (36-42), 4-3 | Fenway Park (1-3) | 44-37 | |
| » Starters: Jack Kralick vs Don Schwall | Fourth | 3½ out |
| Wednesday, July 4 |
| » Defeated Red Sox (36-43), 8-4 | Fenway Park (2-3) | 45-37 | Won 2 |
| » Starters: Joe Bonikowski vs Bill Monbouquette | Fourth | 2 out |
| » Lost to Red Sox (37-43), 9-5 | Fenway Park (2-4) | 45-38 | |
| » Starters: Jim Kaat vs Gene Conley | Fourth | 2 out |
| Friday, July 6 |
| » Lost to Yankees (44-33), 7-5 | Metropolitan Stadium (19-18) | 45-39 | Lost 2 |
| » Starters: Ralph Terry vs Camilo Pascual | Fourth | 3 out |
| Saturday, July 7 |
| » Lost to Yankees (45-33), 6-3 | Metropolitan Stadium (19-19) | 45-40 | Lost 3 |
| » Starters: Bill Stafford vs Jack Kralick | Fourth | 4 out |
| Sunday, July 8 |
| » Lost to Yankees (46-33), 9-8 | Metropolitan Stadium (19-20) | 45-41 | Lost 4 |
| » Starters: Whitey Ford vs Jim Kaat | Fourth | 4½ out |
| Thursday, July 12 |
| » Lost to Senators (27-54), 7-4 | Metropolitan Stadium (19-21) | 45-42 | Lost 5 |
| » Starters: Dave Stenhouse vs Jack Kralick | Fourth | 4½ out |
| Friday, July 13 |
| » Defeated Senators (27-55), 4-0 | Metropolitan Stadium (20-21) | 46-42 | |
| » Starters: Tom Cheney vs Camilo Pascual | Fourth | 3½ out |
| Saturday, July 14 |
| » Lost to Senators (28-55), 4-3 | Metropolitan Stadium (20-22) | 46-43 | |
| » Starters: Bennie Daniels vs Jim Kaat | Fourth | 4½ out |
| Sunday, July 15 |
| » Defeated Red Sox (43-45), 5-3 | Metropolitan Stadium (21-22) | 47-43 | |
| » Starters: Don Schwall vs Bill Pleis | Fourth | 5 out |
| Tuesday, July 17 |
| » Defeated Indians (48-41), 7-2 | Metropolitan Stadium (22-22) | 48-43 | Won 2 |
| » Starters: Gary Bell vs Camilo Pascual | Fourth | 5½ out |
| Wednesday, July 18 |
| » Defeated Indians (48-42), 14-3 | Metropolitan Stadium (23-22) | 49-43 | Won 3 |
| » Starters: Barry Latman vs Dick Stigman | Third | 5½ out |
| Thursday, July 19 |
| » Defeated Indians (48-43), 8-0 | Metropolitan Stadium (24-22) | 50-43 | Won 4 |
| » Starters: Dick Donovan vs Jim Kaat | Third | 5½ out |
| Friday, July 20 |
| » Defeated Orioles (48-46), 7-5 | Metropolitan Stadium (25-22) | 51-43 | Won 5 |
| » Starters: Chuck Estrada vs Jack Kralick | Third | 5½ out |
| Saturday, July 21 |
| » Defeated Orioles (48-47), 7-6 | Metropolitan Stadium (26-22) | 52-43 | Won 6 |
| » Starters: Jack Fisher vs Joe Bonikowski | Third | 5½ out |
| Sunday, July 22 |
| » Lost to Orioles (49-47), 8-6 | Metropolitan Stadium (26-23) | 52-44 | |
| » Starters: Robin Roberts vs Camilo Pascual | Third | 5 out |
| Monday, July 23 |
| » Defeated Tigers (45-49), 8-1 | Metropolitan Stadium (27-23) | 53-44 | |
| » Starters: Paul Foytack vs Dick Stigman | Third | 4½ out |
| Tuesday, July 24 |
| » Lost to Tigers (46-49), 4-3 | Metropolitan Stadium (27-24) | 53-45 | |
| » Starters: Jim Bunning vs Jim Kaat | Third | 5½ out |
| Wednesday, July 25 |
| » Defeated Tigers (46-50), 7-6 | Metropolitan Stadium (28-24) | 54-45 | |
| » Starters: Don Mossi vs Jack Kralick | Third | 5 out |
| Friday, July 27 |
| » Defeated Indians (50-47), 2-1 | Cleveland Stadium (3-2) | 55-45 | Won 2 |
| » Starters: Camilo Pascual vs Jim Perry | Third | 5½ out |
| Saturday, July 28 |
| » Defeated Indians (50-48), 5-2 | Cleveland Stadium (4-2) | 56-45 | Won 3 |
| » Starters: Jim Kaat vs Barry Latman | Third | 5½ out |
| Sunday, July 29 |
| » Lost to Indians (51-48), 3-2 | Cleveland Stadium (4-3) | 56-46 | |
| » Starters: Dick Stigman vs Dick Donovan | Third | 5½ out |
| » Defeated Indians (51-49), 7-5 | Cleveland Stadium (5-3) | 57-46 | |
| » Starters: Jack Kralick vs Ruben Gomez | Third | 5½ out |
| Tuesday, July 31 |
| » Lost to Orioles (54-51), 8-7 | Memorial Stadium (2-2) | 57-47 | |
| » Starters: Jackie Collum vs Jack Fisher | Third | 6½ out |
| Wednesday, August 1 |
| » Defeated Orioles (54-52), 3-1 | Memorial Stadium (3-2) | 58-47 | |
| » Starters: Jim Kaat vs Robin Roberts | Third | 7 out |
| Thursday, August 2 |
| » Defeated Orioles (54-53), 6-3 | Memorial Stadium (4-2) | 59-47 | Won 2 |
| » Starters: Dick Stigman vs Dick Hall | Third | 6½ out |
| Friday, August 3 |
| » Defeated Tigers (51-53), 7-4 | Tiger Stadium (3-0) | 60-47 | Won 3 |
| » Starters: Jack Kralick vs Jim Bunning | Second | 6½ out |
| Saturday, August 4 |
| » Defeated Tigers (51-54), 4-3 | Tiger Stadium (4-0) | 61-47 | Won 4 |
| » Starters: Jackie Collum vs Don Mossi | Second | 5½ out |
| Sunday, August 5 |
| » Defeated Tigers (51-55), 8-3 | Tiger Stadium (5-0) | 62-47 | Won 5 |
| » Starters: Jim Kaat vs Paul Foytack | Second | 5 out |
| » Lost to Tigers (52-55), 5-2 | Tiger Stadium (5-1) | 62-48 | |
| » Starters: Jackie Collum vs Howie Koplitz | Second | 5 out |
| Monday, August 6 |
| » Defeated Yankees (65-42), 5-4 | Yankee Stadium (4-4) | 63-48 | |
| » Starters: Dick Stigman vs Rollie Sheldon | Second | 4 out |
| Tuesday, August 7 |
| » Lost to Yankees (66-42), 14-1 | Yankee Stadium (4-5) | 63-49 | |
| » Starters: Camilo Pascual vs Ralph Terry | Second | 5 out |
| Wednesday, August 8 |
| » Lost to Athletics (52-62), 4-3 | Municipal Stadium (3-5) | 63-50 | Lost 2 |
| » Starters: Jack Kralick vs Diego Segui | Third | 5½ out |
| Thursday, August 9 |
| » Defeated Athletics (52-63), 12-10 | Municipal Stadium (4-5) | 64-50 | |
| » Starters: Lee Stange vs Dan Pfister | Second | 5 out |
| Friday, August 10 |
| » Lost to Angels (65-50), 1-0 | Dodger Stadium (5-2) | 64-51 | |
| » Starters: Jim Kaat vs Dean Chance | Third | 6 out |
| Saturday, August 11 |
| » Lost to Angels (66-50), 3-0 | Dodger Stadium (5-3) | 64-52 | Lost 2 |
| » Starters: Camilo Pascual vs Bo Belinsky | Third | 6½ out |
| Sunday, August 12 |
| » Defeated Angels (66-51), 5-3 | Dodger Stadium (6-3) | 65-52 | |
| » Starters: Dick Stigman vs Don Lee | Third | 6½ out |
| Monday, August 13 |
| » Defeated Yankees (70-45), 6-4 | Metropolitan Stadium (29-24) | 66-52 | Won 2 |
| » Starters: Jim Bouton vs Jack Kralick | Third | 5½ out |
| Tuesday, August 14 |
| » Lost to Yankees (71-45), 5-2 | Metropolitan Stadium (29-25) | 66-53 | |
| » Starters: Whitey Ford vs Bill Pleis | Third | 6½ out |
| Wednesday, August 15 |
| » Lost to Yankees (72-45), 9-3 | Metropolitan Stadium (29-26) | 66-54 | Lost 2 |
| » Starters: Ralph Terry vs Jim Kaat | Third | 7½ out |
| Thursday, August 16 |
| » Defeated Yankees (72-46), 9-8 | Metropolitan Stadium (30-26) | 67-54 | |
| » Starters: Bill Stafford vs Dick Stigman | Third | 6½ out |
| Friday, August 17 |
| » Defeated Red Sox (56-64), 7-3 | Metropolitan Stadium (31-26) | 68-54 | Won 2 |
| » Starters: Ike Delock vs Jack Kralick | Third | 6 out |
| » Lost to Red Sox (57-64), 9-4 | Metropolitan Stadium (31-27) | 68-55 | |
| » Starters: Earl Wilson vs Georges Maranda | Third | 6 out |
| Saturday, August 18 |
| » Lost to Red Sox (58-64), 12-4 | Metropolitan Stadium (31-28) | 68-56 | Lost 2 |
| » Starters: Gene Conley vs Bill Pleis | Third | 6½ out |
| Sunday, August 19 |
| » Defeated Red Sox (58-65), 4-2 | Metropolitan Stadium (32-28) | 69-56 | |
| » Starters: Bill Monbouquette vs Jim Kaat | Third | 6 out |
| » Defeated Red Sox (58-66), 7-4 | Metropolitan Stadium (33-28) | 70-56 | Won 2 |
| » Starters: Hal Kolstad vs Lee Stange | Third | 6 out |
| Monday, August 20 |
| » Defeated Red Sox (58-67), 6-4 | Metropolitan Stadium (34-28) | 71-56 | Won 3 |
| » Starters: Don Schwall vs Dick Stigman | Third | 5 out |
| Tuesday, August 21 |
| » Defeated Senators (46-79), 5-2 | Metropolitan Stadium (35-28) | 72-56 | Won 4 |
| » Starters: Dave Stenhouse vs Jack Kralick | Third | 5 out |
| Wednesday, August 22 |
| » Tied Senators, 8-8 | Metropolitan Stadium (35-28) | 72-56 | |
| » Starters: Claude Osteen vs Lee Stange | Second | 5½ out |
| Future Twin Darrin Jackson is born in Los Angeles, CA. |
| Thursday, August 23 |
| » Lost to Senators (47-79), 6-4 | Metropolitan Stadium (35-29) | 72-57 | |
| » Starters: Ed Hobaugh vs Ruben Gomez | Third | 6 out |
| » Lost to Senators (48-79), 6-0 | Metropolitan Stadium (35-30) | 72-58 | Lost 2 |
| » Starters: Don Rudolph vs Jim Kaat | Third | 6 out |
| Friday, August 24 |
| » Lost to Athletics (60-70), 12-1 | Metropolitan Stadium (35-31) | 72-59 | Lost 3 |
| » Starters: Orlando Pena vs Bill Pleis | Third | 5½ out |
| Saturday, August 25 |
| » Defeated Athletics (60-71), 3-1 | Metropolitan Stadium (36-31) | 73-59 | |
| » Starters: Ed Rakow vs Dick Stigman | Third | 4 out |
| Sunday, August 26 |
| » Defeated Athletics (60-72), 1-0 | Metropolitan Stadium (37-31) | 74-59 | Won 2 |
| » Starters: Bill Fischer vs Jack Kralick | Third | 3 out |
| Tuesday, August 28 |
| » Defeated White Sox (68-64), 2-0 | Comiskey Park I (5-3) | 75-59 | Won 3 |
| » Starters: Jim Kaat vs Early Wynn | Third | 3½ out |
| Wednesday, August 29 |
| » Defeated White Sox (68-65), 5-3 | Comiskey Park I (6-3) | 76-59 | Won 4 |
| » Starters: Camilo Pascual vs Ray Herbert | Second | 2 out |
| Friday, August 31 |
| » Lost to Red Sox (63-71), 7-5 | Fenway Park (2-5) | 76-60 | |
| » Starters: Dick Stigman vs Bill Monbouquette | Second | 3 out |
| Saturday, September 1 |
| » Lost to Red Sox (64-71), 5-4 | Fenway Park (2-6) | 76-61 | Lost 2 |
| » Starters: Jack Kralick vs Earl Wilson | Second | 4 out |
| Sunday, September 2 |
| » Defeated Red Sox (64-72), 5-2 | Fenway Park (3-6) | 77-61 | |
| » Starters: Jim Kaat vs Gene Conley | Second | 4 out |
| Monday, September 3 |
| » Defeated Senators (54-86), 9-3 | Robert F. Kennedy Stadium (4-2) | 78-61 | Won 2 |
| » Starters: Camilo Pascual vs Bob Baird | Second | 3 out |
| » Defeated Senators (54-87), 4-3 | Robert F. Kennedy Stadium (5-2) | 79-61 | Won 3 |
| » Starters: Ruben Gomez vs Bennie Daniels | Second | 3 out |
| Wednesday, September 5 |
| » Defeated Senators (54-88), 9-7 | Robert F. Kennedy Stadium (6-2) | 80-61 | Won 4 |
| » Starters: Dick Stigman vs Dave Stenhouse | Second | 2½ out |
| » Lost to Senators (55-88), 3-0 | Robert F. Kennedy Stadium (6-3) | 80-62 | |
| » Starters: Jack Kralick vs Claude Osteen | Second | 2½ out |
| » Major-league debuts: John Kennedy (Senators) |
| Friday, September 7 |
| » Defeated Tigers (72-68), 6-4 | Tiger Stadium (6-1) | 81-62 | |
| » Starters: Jim Kaat vs Phil Regan | Second | 3 out |
| Saturday, September 8 |
| » Defeated Tigers (72-69), 9-2 | Tiger Stadium (7-1) | 82-62 | Won 2 |
| » Starters: Camilo Pascual vs Don Mossi | Second | 3 out |
| » Major-league debuts: Bob Humphreys (Tigers) |
| Sunday, September 9 |
| » Lost to Tigers (73-69), 10-9 | Tiger Stadium (7-2) | 82-63 | |
| » Starters: Jack Kralick vs Jim Bunning | Second | 2½ out |
| » Major-league debuts: Tony Oliva (Twins) |
| Monday, September 10 |
| » Lost to Angels (81-64), 5-0 | Metropolitan Stadium (37-32) | 82-64 | Lost 2 |
| » Starters: Dean Chance vs Dick Stigman | Second | 3½ out |
| Tuesday, September 11 |
| » Lost to Angels (82-64), 9-0 | Metropolitan Stadium (37-33) | 82-65 | Lost 3 |
| » Starters: Eli Grba vs Jim Kaat | Third | 4½ out |
| Wednesday, September 12 |
| » Lost to White Sox (77-70), 2-1 | Metropolitan Stadium (37-34) | 82-66 | Lost 4 |
| » Starters: Eddie Fisher vs Camilo Pascual | Third | 5½ out |
| Thursday, September 13 |
| » Defeated White Sox (77-71), 5-1 | Metropolitan Stadium (38-34) | 83-66 | |
| » Starters: John Buzhardt vs Jack Kralick | Second | 5 out |
| Friday, September 14 |
| » Defeated Indians (72-77), 11-1 | Metropolitan Stadium (39-34) | 84-66 | Won 2 |
| » Starters: Dick Donovan vs Dick Stigman | Second | 4 out |
| » Major-league debuts: Tommie Agee (Indians) |
| Saturday, September 15 |
| » Defeated Indians (72-78), 12-2 | Metropolitan Stadium (40-34) | 85-66 | Won 3 |
| » Starters: Barry Latman vs Jim Kaat | Second | 4 out |
| Sunday, September 16 |
| » Defeated Indians (72-79), 4-3 | Metropolitan Stadium (41-34) | 86-66 | Won 4 |
| » Starters: Mudcat Grant vs Camilo Pascual | Second | 3 out |
| Monday, September 17 |
| » Major-league debuts: Ken McMullen (Dodgers) |
| Tuesday, September 18 |
| » Lost to Tigers (78-73), 2-1 | Metropolitan Stadium (41-35) | 86-67 | |
| » Starters: Jim Bunning vs Jack Kralick | Second | 4 out |
| Wednesday, September 19 |
| » Defeated Tigers (78-74), 12-5 | Metropolitan Stadium (42-35) | 87-67 | |
| » Starters: Hank Aguirre vs Dick Stigman | Second | 4 out |
| » Major-league debuts: Bill Faul (Tigers) |
| Thursday, September 20 |
| » Lost to Tigers (79-74), 5-1 | Metropolitan Stadium (42-36) | 87-68 | |
| » Starters: Phil Regan vs Jim Kaat | Second | 4½ out |
| » Major-league debuts: Jim Roland (Twins) |
| Friday, September 21 |
| » Lost to Orioles (75-79), 3-2 | Memorial Stadium (4-3) | 87-69 | Lost 2 |
| » Starters: Camilo Pascual vs Robin Roberts | Second | 4½ out |
| » Major-league debuts: Pete Ward (Orioles) |
| Saturday, September 22 |
| » Lost to Orioles (76-79), 5-3 | Memorial Stadium (4-4) | 87-70 | Lost 3 |
| » Starters: Jack Kralick vs Milt Pappas | Second | 4½ out |
| » Major-league debuts: John Miller (Orioles) |
| Sunday, September 23 |
| » Defeated Orioles (76-80), 9-2 | Memorial Stadium (5-4) | 88-70 | |
| » Starters: Dick Stigman vs Chuck Estrada |
