| Saturday, January 27 |
| Former Senator Jim Shaw dies in Washington, DC at the age of 69. Former Senator Joe Vosmik dies in Cleveland, OH at the age of 52. |
| Thursday, March 1 |
| Former Senator Hal Janvrin dies in Boston, MA at the age of 70. |
| Sunday, March 4 |
| Former Senator George Mogridge dies in Rochester, NY at the age of 74. |
| Thursday, March 22 |
| Former Senator Joe Martina dies in New Orleans, LA at the age of 73. |
| Monday, April 9 |
| » Defeated Tigers (0-1), 4-1 | Robert F. Kennedy Stadium (1-0) | 1-0 | |
| » Starters: Don Mossi vs Bennie Daniels | First | -- |
| Tuesday, April 10 |
| » Major-league debuts: Howie Goss (Pirates) |
| Thursday, April 12 |
| » Major-league debuts: Larry Burright and Joe Moeller Pete Richert and Dick Tracewski (Dodgers) |
| Friday, April 13 |
| » Defeated Indians (1-2), 5-2 | Cleveland Stadium (1-0) | 2-0 | Won 2 |
| » Starters: Pete Burnside vs Barry Latman | First | -- |
| Saturday, April 14 |
| » Lost to Indians (2-2), 6-4 | Cleveland Stadium (1-1) | 2-1 | |
| » Starters: Claude Osteen vs Gary Bell | First | -- |
| Sunday, April 15 |
| » Major-league debuts: Dick Phillips (Giants) |
| Tuesday, April 17 |
| » Lost to Tigers (2-2), 9-2 | Tiger Stadium (0-1) | 2-2 | Lost 2 |
| » Starters: Bennie Daniels vs Jim Bunning | Fourth | 1 out |
| » Major-league debuts: Jim Hannan (Senators) |
| Wednesday, April 18 |
| » Lost to Tigers (3-2), 5-1 | Tiger Stadium (0-2) | 2-3 | Lost 3 |
| » Starters: Joe McClain vs Don Mossi | Fifth | 2 out |
| » Major-league debuts: Dave Stenhouse (Senators) |
| Friday, April 20 |
| » Lost to Orioles (4-4), 5-4 | Robert F. Kennedy Stadium (1-1) | 2-4 | Lost 4 |
| » Starters: Billy Hoeft vs Pete Burnside | Ninth | 2½ out |
| Saturday, April 21 |
| » Lost to Orioles (5-4), 3-0 | Robert F. Kennedy Stadium (1-2) | 2-5 | Lost 5 |
| » Starters: Art Quirk vs Claude Osteen | Ninth | 3 out |
| Sunday, April 22 |
| » Lost to Orioles (6-4), 8-3 | Robert F. Kennedy Stadium (1-3) | 2-6 | Lost 6 |
| » Starters: Steve Barber vs Bennie Daniels | Tenth | 3 out |
| Tuesday, April 24 |
| » Lost to Red Sox (5-5), 4-1 | Fenway Park (0-1) | 2-7 | Lost 7 |
| » Starters: Joe McClain vs Galen Cisco | Ninth | 4 out |
| Wednesday, April 25 |
| » Lost to Red Sox (6-5), 7-1 | Fenway Park (0-2) | 2-8 | Lost 8 |
| » Starters: Jim Hannan vs Gene Conley | Ninth | 4 out |
| Thursday, April 26 |
| » Lost to Red Sox (7-5), 8-7 | Fenway Park (0-3) | 2-9 | Lost 9 |
| » Starters: Carl Bouldin vs Don Schwall | Eighth | 5 out |
| Friday, April 27 |
| » Lost to Yankees (7-5), 10-8 | Robert F. Kennedy Stadium (1-4) | 2-10 | Lost 10 |
| » Starters: Bill Stafford vs Pete Burnside | Ninth | 6 out |
| Saturday, April 28 |
| » Lost to Yankees (8-5), 10-3 | Robert F. Kennedy Stadium (1-5) | 2-11 | Lost 11 |
| » Starters: Ralph Terry vs Claude Osteen | Tenth | 7 out |
| Sunday, April 29 |
| » Lost to Yankees (9-5), 3-2 | Robert F. Kennedy Stadium (1-6) | 2-12 | Lost 12 |
| » Starters: Whitey Ford vs Bennie Daniels | Ninth | 8 out |
| » Lost to Yankees (10-5), 11-6 | Robert F. Kennedy Stadium (1-7) | 2-13 | Lost 13 |
| » Starters: Bud Daley vs Joe McClain | Ninth | 8 out |
| Tuesday, May 1 |
| » Defeated Red Sox (7-10), 2-1 | Robert F. Kennedy Stadium (2-7) | 3-13 | |
| » Starters: Gene Conley vs Pete Burnside | Tenth | 8 out |
| Thursday, May 3 |
| » Lost to Red Sox (8-10), 7-4 | Robert F. Kennedy Stadium (2-8) | 3-14 | |
| » Starters: Bill Monbouquette vs Jim Hannan | Tenth | 8½ out |
| Saturday, May 5 |
| » Lost to Yankees (13-6), 7-6 | Yankee Stadium (0-1) | 3-15 | Lost 2 |
| » Starters: Bennie Daniels vs Rollie Sheldon | Tenth | 9½ out |
| Sunday, May 6 |
| » Defeated Yankees (13-7), 4-2 | Yankee Stadium (1-1) | 4-15 | |
| » Starters: Dave Stenhouse vs Ralph Terry | Tenth | 9½ out |
| » Lost to Yankees (14-7), 8-0 | Yankee Stadium (1-2) | 4-16 | |
| » Starters: Pete Burnside vs Jim Bouton | Tenth | 9½ out |
| Wednesday, May 9 |
| » Defeated White Sox (13-13), 9-3 | Robert F. Kennedy Stadium (3-8) | 5-16 | |
| » Starters: John Buzhardt vs Don Rudolph | Eighth | 10 out |
| » Lost to White Sox (14-13), 7-6 | Robert F. Kennedy Stadium (3-9) | 5-17 | |
| » Starters: Ray Herbert vs Steve Hamilton | Eighth | 10 out |
| Thursday, May 10 |
| » Lost to White Sox (15-13), 3-1 | Robert F. Kennedy Stadium (3-10) | 5-18 | Lost 2 |
| » Starters: Early Wynn vs Bennie Daniels | Ninth | 10½ out |
| Friday, May 11 |
| » Defeated Orioles (12-13), 12-1 | Memorial Stadium (1-0) | 6-18 | |
| » Starters: Dave Stenhouse vs Art Quirk | Tenth | 9½ out |
| Saturday, May 12 |
| » Lost to Orioles (13-13), 3-2 | Memorial Stadium (1-1) | 6-19 | |
| » Starters: Pete Burnside vs Steve Barber | Ninth | 10½ out |
| Sunday, May 13 |
| » Lost to Orioles (14-13), 3-2 | Memorial Stadium (1-2) | 6-20 | Lost 2 |
| » Starters: Don Rudolph vs Jack Fisher | Ninth | 10½ out |
| Tuesday, May 15 |
| » Lost to White Sox (18-14), 4-3 | Comiskey Park I (0-1) | 6-21 | Lost 3 |
| » Starters: Tom Cheney vs Ray Herbert | Eighth | 10½ out |
| Wednesday, May 16 |
| » Defeated White Sox (18-15), 3-1 | Comiskey Park I (1-1) | 7-21 | |
| » Starters: Dave Stenhouse vs Early Wynn | Ninth | 10½ out |
| Friday, May 18 |
| » Defeated Athletics (14-20), 3-2 | Robert F. Kennedy Stadium (4-10) | 8-21 | Won 2 |
| » Starters: Dan Pfister vs Pete Burnside | Tenth | 10½ out |
| Saturday, May 19 |
| » Lost to Athletics (15-20), 8-4 | Robert F. Kennedy Stadium (4-11) | 8-22 | |
| » Starters: Art Ditmar vs Don Rudolph | Ninth | 10½ out |
| Sunday, May 20 |
| » Lost to Athletics (16-20), 1-0 | Robert F. Kennedy Stadium (4-12) | 8-23 | Lost 2 |
| » Starters: Ed Rakow vs Claude Osteen | Ninth | 10½ out |
| » Defeated Athletics (16-21), 7-5 | Robert F. Kennedy Stadium (5-12) | 9-23 | |
| » Starters: Jim Archer vs Tom Cheney | Ninth | 10½ out |
| Monday, May 21 |
| » Lost to Twins (22-15), 5-3 | Robert F. Kennedy Stadium (5-13) | 9-24 | |
| » Starters: Camilo Pascual vs Dave Stenhouse | Tenth | 11½ out |
| Tuesday, May 22 |
| » Lost to Twins (23-15), 6-5 | Robert F. Kennedy Stadium (5-14) | 9-25 | Lost 2 |
| » Starters: Georges Maranda vs Joe McClain | Tenth | 12 out |
| Wednesday, May 23 |
| » Defeated Angels (18-17), 7-2 | Robert F. Kennedy Stadium (6-14) | 10-25 | |
| » Starters: Ted Bowsfield vs Pete Burnside | Tenth | 12 out |
| Thursday, May 24 |
| » Lost to Angels (19-17), 7-4 | Robert F. Kennedy Stadium (6-15) | 10-26 | |
| » Starters: Bo Belinsky vs Don Rudolph | Tenth | 13 out |
| Former Senator Rabbit Nill dies in Fort Wayne, IN at the age of 81. |
| Friday, May 25 |
| » Lost to Indians (23-14), 2-1 | Robert F. Kennedy Stadium (6-16) | 10-27 | Lost 2 |
| » Starters: Pedro Ramos vs Claude Osteen | Ninth | 13 out |
| Saturday, May 26 |
| » Defeated Indians (23-15), 8-6 | Robert F. Kennedy Stadium (7-16) | 11-27 | |
| » Starters: Mudcat Grant vs Dave Stenhouse | Ninth | 12 out |
| Sunday, May 27 |
| » Lost to Indians (24-15), 5-3 | Robert F. Kennedy Stadium (7-17) | 11-28 | |
| » Starters: Jim Perry vs Bennie Daniels | Ninth | 13 out |
| Monday, May 28 |
| » Lost to Angels (22-19), 6-4 | Dodger Stadium (0-1) | 11-29 | Lost 2 |
| » Starters: Pete Burnside vs Bo Belinsky | Ninth | 13 out |
| Tuesday, May 29 |
| » Defeated Angels (22-20), 7-6 | Dodger Stadium (1-1) | 12-29 | |
| » Starters: Don Rudolph vs Ken McBride | Tenth | 12½ out |
| Wednesday, May 30 |
| » Defeated Athletics (21-26), 8-0 | Municipal Stadium (1-0) | 13-29 | Won 2 |
| » Starters: Claude Osteen vs Ed Rakow | Tenth | 12½ out |
| » Lost to Athletics (22-26), 5-2 | Municipal Stadium (1-1) | 13-30 | |
| » Starters: Tom Cheney vs Norm Bass | Tenth | 12½ out |
| Thursday, May 31 |
| » Lost to Athletics (23-26), 1-0 | Municipal Stadium (1-2) | 13-31 | Lost 2 |
| » Starters: Steve Hamilton vs Jerry Walker | Tenth | 13½ out |
| Friday, June 1 |
| » Defeated Twins (27-22), 4-3 | Metropolitan Stadium (1-0) | 14-31 | |
| » Starters: Dave Stenhouse vs Jim Kaat | Tenth | 13½ out |
| Saturday, June 2 |
| » Lost to Twins (28-22), 9-2 | Metropolitan Stadium (1-1) | 14-32 | |
| » Starters: Pete Burnside vs Joe Bonikowski | Tenth | 13½ out |
| Sunday, June 3 |
| » Lost to Twins (29-22), 7-5 | Metropolitan Stadium (1-2) | 14-33 | Lost 2 |
| » Starters: Bennie Daniels vs Jack Kralick | Ninth | 13½ out |
| Tuesday, June 5 |
| » Lost to Orioles (24-26), 6-5 | Memorial Stadium (1-3) | 14-34 | Lost 3 |
| » Starters: Don Rudolph vs Milt Pappas | Ninth | 14 out |
| Wednesday, June 6 |
| » Defeated Orioles (24-27), 2-1 | Memorial Stadium (2-3) | 15-34 | |
| » Starters: Claude Osteen vs Robin Roberts | Tenth | 14 out |
| Thursday, June 7 |
| » Lost to Orioles (25-27), 12-5 | Memorial Stadium (2-4) | 15-35 | |
| » Starters: Pete Burnside vs Jack Fisher | Tenth | 15 out |
| Friday, June 8 |
| » Lost to Tigers (28-22), 7-6 | Robert F. Kennedy Stadium (7-18) | 15-36 | Lost 2 |
| » Starters: Paul Foytack vs Steve Hamilton | Tenth | 15½ out |
| » Defeated Tigers (28-23), 1-0 | Robert F. Kennedy Stadium (8-18) | 16-36 | |
| » Starters: Don Mossi vs Dave Stenhouse | Tenth | 15½ out |
| Saturday, June 9 |
| » Defeated Tigers (28-24), 4-2 | Robert F. Kennedy Stadium (9-18) | 17-36 | Won 2 |
| » Starters: Hank Aguirre vs Tom Cheney | Ninth | 15½ out |
| Sunday, June 10 |
| » Defeated Tigers (28-25), 2-1 | Robert F. Kennedy Stadium (10-18) | 18-36 | Won 3 |
| » Starters: Phil Regan vs Don Rudolph | Tenth | 13½ out |
| » Defeated Tigers (28-26), 5-4 | Robert F. Kennedy Stadium (11-18) | 19-36 | Won 4 |
| » Starters: Jim Bunning vs Bennie Daniels | Tenth | 13½ out |
| Wednesday, June 13 |
| » Defeated Indians (31-23), 4-2 | Robert F. Kennedy Stadium (12-18) | 20-36 | Won 5 |
| » Starters: Pedro Ramos vs Claude Osteen | Tenth | 13½ out |
| » Lost to Indians (32-23), 4-1 | Robert F. Kennedy Stadium (12-19) | 20-37 | |
| » Starters: Dick Donovan vs Dave Stenhouse | Tenth | 13½ out |
| Thursday, June 14 |
| » Defeated Indians (32-24), 4-3 | Robert F. Kennedy Stadium (13-19) | 21-37 | |
| » Starters: Barry Latman vs Tom Cheney | Tenth | 13 out |
| Friday, June 15 |
| » Lost to Orioles (30-31), 8-3 | Robert F. Kennedy Stadium (13-20) | 21-38 | |
| » Starters: Milt Pappas vs Don Rudolph | Tenth | 13 out |
| Saturday, June 16 |
| » Lost to Orioles (31-31), 4-3 | Robert F. Kennedy Stadium (13-21) | 21-39 | Lost 2 |
| » Starters: Robin Roberts vs Pete Burnside | Tenth | 14 out |
| Sunday, June 17 |
| » Lost to Orioles (32-31), 4-3 | Robert F. Kennedy Stadium (13-22) | 21-40 | Lost 3 |
| » Starters: Hal Brown vs Bennie Daniels | Tenth | 15½ out |
| Tuesday, June 19 |
| » Lost to Tigers (30-30), 5-0 | Tiger Stadium (0-3) | 21-41 | Lost 4 |
| » Starters: Claude Osteen vs Frank Lary | Ninth | 15½ out |
| Wednesday, June 20 |
| » Defeated Tigers (30-31), 5-4 | Tiger Stadium (1-3) | 22-41 | |
| » Starters: Tom Cheney vs Don Mossi | Tenth | 16 out |
| Thursday, June 21 |
| » Lost to Tigers (31-31), 6-3 | Tiger Stadium (1-4) | 22-42 | |
| » Starters: Don Rudolph vs Jim Bunning | Tenth | 16 out |
| Friday, June 22 |
| » Lost to Indians (39-26), 6-2 | Cleveland Stadium (1-2) | 22-43 | Lost 2 |
| » Starters: Bennie Daniels vs Dick Donovan | Tenth | 17 out |
| Saturday, June 23 |
| » Defeated Indians (39-27), 5-3 | Cleveland Stadium (2-2) | 23-43 | |
| » Starters: Dave Stenhouse vs Mudcat Grant | Tenth | 16 out |
| Sunday, June 24 |
| » Defeated Indians (39-28), 3-1 | Cleveland Stadium (3-2) | 24-43 | Won 2 |
| » Starters: Claude Osteen vs Jim Perry | Tenth | 16 out |
| » Lost to Indians (40-28), 4-2 | Cleveland Stadium (3-3) | 24-44 | |
| » Starters: Pete Burnside vs Barry Latman | Tenth | 16 out |
| Tuesday, June 26 |
| » Lost to Athletics (33-40), 2-1 | Robert F. Kennedy Stadium (13-23) | 24-45 | Lost 2 |
| » Starters: Dan Pfister vs Tom Cheney | Tenth | 16½ out |
| Wednesday, June 27 |
| » Lost to Athletics (34-40), 4-1 | Robert F. Kennedy Stadium (13-24) | 24-46 | Lost 3 |
| » Starters: Ed Rakow vs Steve Hamilton | Tenth | 16½ out |
| Thursday, June 28 |
| » Lost to Athletics (35-40), 10-7 | Robert F. Kennedy Stadium (13-25) | 24-47 | Lost 4 |
| » Starters: Jerry Walker vs Bennie Daniels | Tenth | 17 out |
| Friday, June 29 |
| » Defeated Twins (42-35), 6-3 | Robert F. Kennedy Stadium (14-25) | 25-47 | |
| » Starters: Joe Bonikowski vs Dave Stenhouse | Tenth | 16 out |
| Saturday, June 30 |
| » Defeated Twins (42-36), 1-0 | Robert F. Kennedy Stadium (15-25) | 26-47 | Won 2 |
| » Starters: Jim Kaat vs Tom Cheney | Tenth | 15 out |
| Sunday, July 1 |
| » Lost to Twins (43-36), 9-0 | Robert F. Kennedy Stadium (15-26) | 26-48 | |
| » Starters: Camilo Pascual vs Ray Rippelmeyer | Tenth | 15 out |
| Former Senator Sam Mayer dies in Atlanta, GA at the age of 70. |
| Monday, July 2 |
| » Lost to Angels (43-34), 2-1 | Robert F. Kennedy Stadium (15-27) | 26-49 | Lost 2 |
| » Starters: Eli Grba vs Pete Burnside | Tenth | 16 out |
| Wednesday, July 4 |
| » Lost to Angels (44-34), 4-2 | Robert F. Kennedy Stadium (15-28) | 26-50 | Lost 3 |
| » Starters: Ken McBride vs Dave Stenhouse | Tenth | 18 out |
| » Lost to Angels (45-34), 4-1 | Robert F. Kennedy Stadium (15-29) | 26-51 | Lost 4 |
| » Starters: Ted Bowsfield vs Claude Osteen | Tenth | 18 out |
| Friday, July 6 |
| » Lost to Athletics (38-45), 12-9 | Municipal Stadium (1-3) | 26-52 | Lost 5 |
| » Starters: Tom Cheney vs Ed Rakow | Tenth | 19 out |
| Saturday, July 7 |
| » Lost to Athletics (39-45), 9-8 | Municipal Stadium (1-4) | 26-53 | Lost 6 |
| » Starters: Pete Burnside vs Jerry Walker | Tenth | 20 out |
| Sunday, July 8 |
| » Lost to Athletics (40-45), 6-5 | Municipal Stadium (1-5) | 26-54 | Lost 7 |
| » Starters: Don Rudolph vs Diego Segui | Tenth | 20½ out |
| Thursday, July 12 |
| » Defeated Twins (45-42), 7-4 | Metropolitan Stadium (2-2) | 27-54 | |
| » Starters: Dave Stenhouse vs Jack Kralick | Tenth | 19½ out |
| Friday, July 13 |
| » Lost to Twins (46-42), 4-0 | Metropolitan Stadium (2-3) | 27-55 | |
| » Starters: Tom Cheney vs Camilo Pascual | Tenth | 19½ out |
| Saturday, July 14 |
| » Defeated Twins (46-43), 4-3 | Metropolitan Stadium (3-3) | 28-55 | |
| » Starters: Bennie Daniels vs Jim Kaat | Tenth | 19½ out |
| Sunday, July 15 |
| » Lost to Angels (48-38), 5-1 | Dodger Stadium (1-2) | 28-56 | |
| » Starters: Pete Burnside vs Eli Grba | Tenth | 20½ out |
| » Defeated Angels (48-39), 10-4 | Dodger Stadium (2-2) | 29-56 | |
| » Starters: Steve Hamilton vs Ryne Duren | Tenth | 20½ out |
| Monday, July 16 |
| » Defeated Angels (48-40), 4-1 | Dodger Stadium (3-2) | 30-56 | Won 2 |
| » Starters: Don Rudolph vs Ted Bowsfield | Ninth | 20½ out |
| Tuesday, July 17 |
| » Defeated White Sox (47-46), 1-0 | Comiskey Park I (2-1) | 31-56 | Won 3 |
| » Starters: Dave Stenhouse vs Juan Pizarro | Tenth | 20 out |
| » Defeated White Sox (47-47), 7-3 | Comiskey Park I (3-1) | 32-56 | Won 4 |
| » Starters: Tom Cheney vs Early Wynn | Tenth | 20 out |
| » Major-league debuts: Ramon Conde (White Sox) Don Lock (Senators) |
| Wednesday, July 18 |
| » Defeated White Sox (47-48), 1-0 | Comiskey Park I (4-1) | 33-56 | Won 5 |
| » Starters: Bennie Daniels vs Ray Herbert | Tenth | 20 out |
| Friday, July 20 |
| » Lost to Yankees (54-35), 3-2 | Yankee Stadium (1-3) | 33-57 | |
| » Starters: Steve Hamilton vs Whitey Ford | Tenth | 21½ out |
| Saturday, July 21 |
| » Lost to Yankees (55-35), 4-3 | Yankee Stadium (1-4) | 33-58 | Lost 2 |
| » Starters: Don Rudolph vs Ralph Terry | Tenth | 22½ out |
| Sunday, July 22 |
| » Defeated Yankees (55-36), 3-2 | Yankee Stadium (2-4) | 34-58 | |
| » Starters: Dave Stenhouse vs Bill Stafford | Tenth | 20½ out |
| » Defeated Yankees (55-37), 8-3 | Yankee Stadium (3-4) | 35-58 | Won 2 |
| » Starters: Bennie Daniels vs Jim Bouton | Tenth | 20½ out |
| Tuesday, July 24 |
| » Lost to White Sox (50-49), 6-0 | Robert F. Kennedy Stadium (15-30) | 35-59 | |
| » Starters: Early Wynn vs Tom Cheney | Ninth | 21½ out |
| Wednesday, July 25 |
| » Defeated White Sox (50-50), 4-3 | Robert F. Kennedy Stadium (16-30) | 36-59 | |
| » Starters: Juan Pizarro vs Claude Osteen | Ninth | 21 out |
| Thursday, July 26 |
| » Lost to White Sox (51-50), 7-1 | Robert F. Kennedy Stadium (16-31) | 36-60 | |
| » Starters: Ray Herbert vs Bennie Daniels | Tenth | 22 out |
| Friday, July 27 |
| » Defeated Red Sox (45-54), 11-2 | Robert F. Kennedy Stadium (17-31) | 37-60 | |
| » Starters: Bill Monbouquette vs Dave Stenhouse | Tenth | 21½ out |
| » Defeated Red Sox (45-55), 14-1 | Robert F. Kennedy Stadium (18-31) | 38-60 | Won 2 |
| » Starters: Galen Cisco vs Don Rudolph | Tenth | 21½ out |
| Saturday, July 28 |
| » Defeated Red Sox (45-56), 9-1 | Robert F. Kennedy Stadium (19-31) | 39-60 | Won 3 |
| » Starters: Arnold Earley vs Pete Burnside | Tenth | 21½ out |
| Sunday, July 29 |
| » Lost to Red Sox (46-56), 4-2 | Robert F. Kennedy Stadium (19-32) | 39-61 | |
| » Starters: Earl Wilson vs Tom Cheney | Tenth | 22 out |
| Former Senator Burt Shotton dies in Lake Wales, FL at the age of 78. |
| Tuesday, July 31 |
| » Lost to Yankees (62-39), 9-5 | Robert F. Kennedy Stadium (19-33) | 39-62 | Lost 2 |
| » Starters: Bill Stafford vs Claude Osteen | Tenth | 23 out |
| Wednesday, August 1 |
| » Lost to Yankees (63-39), 6-4 | Robert F. Kennedy Stadium (19-34) | 39-63 | Lost 3 |
| » Starters: Jim Bouton vs Bennie Daniels | Tenth | 25 out |
| » Lost to Yankees (64-39), 5-2 | Robert F. Kennedy Stadium (19-35) | 39-64 | Lost 4 |
| » Starters: Whitey Ford vs Dave Stenhouse | Tenth | 25 out |
| Friday, August 3 |
| » Defeated Red Sox (48-57), 2-1 | Fenway Park (1-3) | 40-64 | |
| » Starters: Don Rudolph vs Earl Wilson | Ninth | 25 out |
| Saturday, August 4 |
| » Defeated Red Sox (48-58), 5-3 | Fenway Park (2-3) | 41-64 | Won 2 |
| » Starters: Pete Burnside vs Gene Conley | Tenth | 24 out |
| Sunday, August 5 |
| » Defeated Red Sox (48-59), 2-0 | Fenway Park (3-3) | 42-64 | Won 3 |
| » Starters: Tom Cheney vs Bill Monbouquette | Tenth | 23½ out |
| » Lost to Red Sox (49-59), 5-4 | Fenway Park (3-4) | 42-65 | |
| » Starters: Bennie Daniels vs Hal Kolstad | Tenth | 23½ out |
| Monday, August 6 |
| » Lost to Athletics (50-62), 1-0 | Robert F. Kennedy Stadium (19-36) | 42-66 | Lost 2 |
| » Starters: Ed Rakow vs Claude Osteen | Tenth | 23½ out |
| Tuesday, August 7 |
| » Lost to Athletics (51-62), 10-3 | Robert F. Kennedy Stadium (19-37) | 42-67 | Lost 3 |
| » Starters: Bill Fischer vs Don Rudolph | Tenth | 24½ out |
| Wednesday, August 8 |
| » Lost to Tigers (53-57), 6-5 | Robert F. Kennedy Stadium (19-38) | 42-68 | Lost 4 |
| » Starters: Don Mossi vs Dave Stenhouse | Tenth | 25½ out |
| » Lost to Tigers (54-57), 10-3 | Robert F. Kennedy Stadium (19-39) | 42-69 | Lost 5 |
| » Starters: Phil Regan vs Pete Burnside | Tenth | 25½ out |
| Thursday, August 9 |
| » Lost to Tigers (55-57), 8-5 | Robert F. Kennedy Stadium (19-40) | 42-70 | Lost 6 |
| » Starters: Howie Koplitz vs Tom Cheney | Eighth | 26 out |
| Friday, August 10 |
| » Lost to Indians (56-57), 3-0 | Robert F. Kennedy Stadium (19-41) | 42-71 | Lost 7 |
| » Starters: Pedro Ramos vs Dave Stenhouse | Tenth | 27 out |
| Saturday, August 11 |
| » Defeated Indians (56-58), 9-2 | Robert F. Kennedy Stadium (20-41) | 43-71 | |
| » Starters: Sam McDowell vs Claude Osteen | Tenth | 26½ out |
| Sunday, August 12 |
| » Lost to Indians (57-58), 5-3 | Robert F. Kennedy Stadium (20-42) | 43-72 | |
| » Starters: Mudcat Grant vs Steve Hamilton | Tenth | 27½ out |
| Monday, August 13 |
| » Defeated Indians (57-59), 11-2 | Cleveland Stadium (4-3) | 44-72 | |
| » Starters: Jim Hannan vs Dick Donovan | Tenth | 26 out |
| » Defeated Indians (57-60), 3-2 | Cleveland Stadium (5-3) | 45-72 | Won 2 |
| » Starters: Don Rudolph vs Barry Latman | Tenth | 26 out |
| Tuesday, August 14 |
| » Lost to Athletics (53-66), 6-5 | Municipal Stadium (1-6) | 45-73 | |
| » Starters: Tom Cheney vs Orlando Pena | Tenth | 27 out |
| Wednesday, August 15 |
| » Lost to Athletics (54-66), 8-4 | Municipal Stadium (1-7) | 45-74 | Lost 2 |
| » Starters: Dave Stenhouse vs Dan Pfister | Ninth | 28 out |
| Thursday, August 16 |
| » Lost to Athletics (55-66), 4-2 | Municipal Stadium (1-8) | 45-75 | Lost 3 |
| » Starters: Claude Osteen vs Ed Rakow | Tenth | 28 out |
| Friday, August 17 |
| » Lost to Angels (69-53), 4-3 | Dodger Stadium (3-3) | 45-76 | Lost 4 |
| » Starters: Steve Hamilton vs Bo Belinsky | Tenth | 28½ out |
| » Lost to Angels (70-53), 3-2 | Dodger Stadium (3-4) | 45-77 | Lost 5 |
| » Starters: Ed Hobaugh vs Don Lee | Tenth | 28½ out |
| Saturday, August 18 |
| » Defeated Angels (70-54), 2-0 | Dodger Stadium (4-4) | 46-77 | |
| » Starters: Don Rudolph vs Ted Bowsfield | Tenth | 28 out |
| Sunday, August 19 |
| » Lost to Angels (71-54), 5-2 | Dodger Stadium (4-5) | 46-78 | |
| » Starters: Tom Cheney vs Dean Chance | Tenth | 29 out |
| Tuesday, August 21 |
| » Lost to Twins (72-56), 5-2 | Metropolitan Stadium (3-4) | 46-79 | Lost 2 |
| » Starters: Dave Stenhouse vs Jack Kralick | Tenth | 29½ out |
| Wednesday, August 22 |
| » Tied Twins, 8-8 | Metropolitan Stadium (3-4) | 46-79 | |
| » Starters: Claude Osteen vs Lee Stange | Tenth | 30 out |
| Thursday, August 23 |
| » Defeated Twins (72-57), 6-4 | Metropolitan Stadium (4-4) | 47-79 | |
| » Starters: Ed Hobaugh vs Ruben Gomez | Tenth | 28½ out |
| » Defeated Twins (72-58), 6-0 | Metropolitan Stadium (5-4) | 48-79 | Won 2 |
| » Starters: Don Rudolph vs Jim Kaat | Tenth | 28½ out |
| Friday, August 24 |
| » Lost to Tigers (64-63), 11-1 | Tiger Stadium (1-5) | 48-80 | |
| » Starters: Pete Burnside vs Phil Regan | Tenth | 28 out |
| Saturday, August 25 |
| » Lost to Tigers (65-63), 7-5 | Tiger Stadium (1-6) | 48-81 | Lost 2 |
| » Starters: Steve Hamilton vs Howie Koplitz | Tenth | 27½ out |
| Sunday, August 26 |
| » Lost to Tigers (66-63), 5-3 | Tiger Stadium (1-7) | 48-82 | Lost 3 |
| » Starters: Dave Stenhouse vs Jim Bunning | Ninth | 27 out |
| » Defeated Tigers (66-64), 5-2 | Tiger Stadium (2-7) | 49-82 | |
| » Starters: Claude Osteen vs Ron Kline | Ninth | 27 out |
| Monday, August 27 |
| » Defeated Orioles (66-65), 7-0 | Robert F. Kennedy Stadium (21-42) | 50-82 | Won 2 |
| » Starters: Billy Hoeft vs Tom Cheney | Ninth | 27 out |
| Tuesday, August 28 |
| » Defeated Orioles (66-66), 4-0 | Robert F. Kennedy Stadium (22-42) | 51-82 | Won 3 |
| » Starters: Jack Fisher vs Don Rudolph | Tenth | 27 out |
| Wednesday, August 29 |
| » Lost to Orioles (67-66), 9-3 | Robert F. Kennedy Stadium (22-43) | 51-83 | |
| » Starters: Chuck Estrada vs Bennie Daniels | Tenth | 26½ out |
| Thursday, August 30 |
| » Defeated Orioles (67-67), 3-2 | Memorial Stadium (3-4) | 52-83 | |
| » Starters: Dave Stenhouse vs Dick Hall | Tenth | 26 out |
| Friday, August 31 |
| » Lost to Angels (75-59), 6-3 | Robert F. Kennedy Stadium (22-44) | 52-84 | |
| » Starters: Ted Bowsfield vs Claude Osteen | Tenth | 26½ out |
| » Defeated Angels (75-60), 4-2 | Robert F. Kennedy Stadium (23-44) | 53-84 | |
| » Starters: Don Lee vs Steve Hamilton | Tenth | 26½ out |
| Saturday, September 1 |
| » Defeated Angels (75-61), 3-2 | Robert F. Kennedy Stadium (24-44) | 54-84 | Won 2 |
| » Starters: Dean Chance vs Tom Cheney | Tenth | 26½ out |
| Sunday, September 2 |
| » Lost to Angels (76-61), 4-2 | Robert F. Kennedy Stadium (24-45) | 54-85 | |
| » Starters: Eli Grba vs Don Rudolph | Tenth | 27½ out |
| Monday, September 3 |
| » Lost to Twins (78-61), 9-3 | Robert F. Kennedy Stadium (24-46) | 54-86 | Lost 2 |
| » Starters: Camilo Pascual vs Bob Baird | Tenth | 28½ out |
| » Lost to Twins (79-61), 4-3 | Robert F. Kennedy Stadium (24-47) | 54-87 | Lost 3 |
| » Starters: Ruben Gomez vs Bennie Daniels | Tenth | 28½ out |
| Wednesday, September 5 |
| » Lost to Twins (80-61), 9-7 | Robert F. Kennedy Stadium (24-48) | 54-88 | Lost 4 |
| » Starters: Dick Stigman vs Dave Stenhouse | Tenth | 28 out |
| » Defeated Twins (80-62), 3-0 | Robert F. Kennedy Stadium (25-48) | 55-88 | |
| » Starters: Jack Kralick vs Claude Osteen | Tenth | 28 out |
| » Major-league debuts: John Kennedy (Senators) |
| Friday, September 7 |
| » Defeated White Sox (72-70), 7-2 | Comiskey Park I (5-1) | 56-88 | Won 2 |
| » Starters: Tom Cheney vs Eddie Fisher | Tenth | 28½ out |
| Saturday, September 8 |
| » Lost to White Sox (73-70), 6-3 | Comiskey Park I (5-2) | 56-89 | |
| » Starters: Don Rudolph vs Early Wynn | Tenth | 29½ out |
| » Major-league debuts: Deacon Jones (White Sox) |
| Sunday, September 9 |
| » Lost to White Sox (74-70), 4-3 | Comiskey Park I (5-3) | 56-90 | Lost 2 |
| » Starters: Dave Stenhouse vs Joe Horlen | Tenth | 29½ out |
| » Lost to White Sox (75-70), 3-2 | Comiskey Park I (5-4) | 56-91 | Lost 3 |
| » Starters: Bob Baird vs John Buzhardt | Tenth | 29½ out |
| » Major-league debuts: Ken Berry (White Sox) |
| Tuesday, September 11 |
| » Lost to Indians (72-75), 3-0 | Cleveland Stadium (5-4) | 56-92 | Lost 4 |
| » Starters: Claude Osteen vs Jim Perry | Tenth | 31 out |
| » Major-league debuts: Max Alvis (Indians) |
| Wednesday, September 12 |
| » Defeated Orioles (72-75), 2-1 | Memorial Stadium (4-4) | 57-92 | |
| » Starters: Tom Cheney vs Milt Pappas | Tenth | 31 out |
| Thursday, September 13 |
| » Lost to Orioles (73-75), 7-1 | Memorial Stadium (4-5) | 57-93 | |
| » Starters: Don Rudolph vs Chuck Estrada | Tenth | 31½ out |
| Friday, September 14 |
| » Lost to White Sox (78-71), 2-0 | Robert F. Kennedy Stadium (25-49) | 57-94 | Lost 2 |
| » Starters: Joe Horlen vs Dave Stenhouse | Tenth | 31½ out |
| Saturday, September 15 |
| » Defeated White Sox (78-72), 3-1 | Robert F. Kennedy Stadium (26-49) | 58-94 | |
| » Starters: Juan Pizarro vs Carl Bouldin | Tenth | 31½ out |
| » Major-league debuts: Al Weis (White Sox) |
| Sunday, September 16 |
| » Lost to White Sox (79-72), 7-4 | Robert F. Kennedy Stadium (26-50) | 58-95 | |
| » Starters: Ray Herbert vs Claude Osteen | Ninth | 31½ out |
| Tuesday, September 18 |
| » Lost to Yankees (90-63), 7-1 | Robert F. Kennedy Stadium (26-51) | 58-96 | Lost 2 |
| » Starters: Ralph Terry vs Tom Cheney | Tenth | 32½ out |
| Wednesday, September 19 |
| » Lost to Yankees (91-63), 8-5 | Robert F. Kennedy Stadium (26-52) | 58-97 | Lost 3 |
| » Starters: Bill Stafford vs Dave Stenhouse | Ninth | 33½ out |
| Friday, September 21 |
| » Lost to Red Sox (74-81), 4-1 | Robert F. Kennedy Stadium (26-53) | 58-98 | Lost 4 |
| » Starters: Gene Conley vs Carl Bouldin | Tenth | 33½ out |
| Saturday, September 22 |
| » Defeated Red Sox (74-82), 4-3 | Robert F. Kennedy Stadium (27-53) | 59-98 | |
| » Starters: Wilbur Wood vs Bob Baird | Tenth | 32½ out |
| Tuesday, September 25 |
| » Lost to Yankees (93-65), 8-3 | Yankee Stadium (3-5) | 59-99 | |
| » Starters: Bennie Daniels vs Whitey Ford | Tenth | 34 out |
| Wednesday, September 26 |
| » Lost to Yankees (94-65), 9-5 | Yankee Stadium (3-6) | 59-100 | Lost 2 |
| » Starters: Don Rudolph vs Ralph Terry | Tenth | 35 out |
| Sunday, September 30 |
| » Defeated Red Sox (75-84), 3-1 | Fenway Park (4-4) | 60-100 | |
| » Starters: Tom Cheney vs Gene Conley | Tenth | 35½ out |
| » Lost to Red Sox (76-84), 3-1 | Fenway Park (4-5) | 60-101 | |
| » Starters: Jack Jenkins vs Bill Monbouquette | Tenth | 35½ out |
|
