| Sunday, January 7 |
| Former Red Sox Dutch Lerchen dies in Detroit, MI at the age of 73. |
| Saturday, January 13 |
| Future Red Sox Kevin Mitchell is born in San Diego, CA. |
| Friday, January 26 |
| Former Red Sox Steve O'Neill dies in Cleveland, OH at the age of 71. |
| Saturday, January 27 |
| Former Red Sox Joe Vosmik dies in Cleveland, OH at the age of 52. |
| Saturday, February 24 |
| Former Red Sox Max Bishop dies in Waynesboro, PA at the age of 63. |
| Thursday, March 1 |
| Former Red Sox Hal Janvrin dies in Boston, MA at the age of 70. |
| Saturday, March 17 |
| Former Red Sox Billy Purtell dies in Bradenton, FL at the age of 77. |
| Monday, March 19 |
| Future Red Sox Ivan Calderon is born in Fajardo, P.R. |
| Tuesday, April 10 |
| » Lost to Indians (1-0), 4-0 | Fenway Park (0-1) | 0-1 | |
| » Starters: Dick Donovan vs Don Schwall | Second | 1 out |
| Wednesday, April 11 |
| » Defeated Indians (1-1), 4-0 | Fenway Park (1-1) | 1-1 | |
| » Starters: Ron Taylor vs Bill Monbouquette | Second | ½ out |
| » Major-league debuts: Ron Taylor (Indians) |
| Friday, April 13 |
| » Major-league debuts: Bob Uecker (Braves) |
| Saturday, April 14 |
| » Lost to Orioles (1-1), 3-0 | Memorial Stadium (0-1) | 1-2 | |
| » Starters: Gene Conley vs Chuck Estrada | Fifth | 1 out |
| Sunday, April 15 |
| » Lost to Orioles (2-1), 5-1 | Memorial Stadium (0-2) | 1-3 | Lost 2 |
| » Starters: Don Schwall vs Steve Barber | Fifth | 1½ out |
| » Defeated Orioles (2-2), 5-4 | Memorial Stadium (1-2) | 2-3 | |
| » Starters: Galen Cisco vs Billy Hoeft | Fifth | 1½ out |
| » Major-league debuts: Bob Tillman (Red Sox) |
| Monday, April 16 |
| » Major-league debuts: Hank Fischer (Braves) |
| Tuesday, April 17 |
| » Lost to Indians (3-2), 5-0 | Cleveland Stadium (0-1) | 2-4 | |
| » Starters: Bill Monbouquette vs Dick Donovan | Seventh | 2 out |
| Thursday, April 19 |
| » Defeated Tigers (3-3), 9-5 | Fenway Park (2-1) | 3-4 | |
| » Starters: Phil Regan vs Gene Conley | Sixth | 2½ out |
| Saturday, April 21 |
| » Defeated Tigers (3-4), 4-3 | Fenway Park (3-1) | 4-4 | Won 2 |
| » Starters: Frank Lary vs Don Schwall | Fifth | 1½ out |
| Sunday, April 22 |
| » Lost to Tigers (4-4), 8-6 | Fenway Park (3-2) | 4-5 | |
| » Starters: Jim Bunning vs Bill Monbouquette | Ninth | 1½ out |
| Tuesday, April 24 |
| » Defeated Senators (2-7), 4-1 | Fenway Park (4-2) | 5-5 | |
| » Starters: Joe McClain vs Galen Cisco | Fifth | 1½ out |
| Wednesday, April 25 |
| » Defeated Senators (2-8), 7-1 | Fenway Park (5-2) | 6-5 | Won 2 |
| » Starters: Jim Hannan vs Gene Conley | Third | ½ out |
| Thursday, April 26 |
| » Defeated Senators (2-9), 8-7 | Fenway Park (6-2) | 7-5 | Won 3 |
| » Starters: Carl Bouldin vs Don Schwall | Second | ½ out |
| Friday, April 27 |
| » Lost to White Sox (8-7), 7-4 | Comiskey Park I (0-1) | 7-6 | |
| » Starters: Bill Monbouquette vs Joe Horlen | Third | 1½ out |
| Saturday, April 28 |
| » Lost to White Sox (9-7), 7-6 | Comiskey Park I (0-2) | 7-7 | Lost 2 |
| » Starters: Billy Muffett vs Ray Herbert | Sixth | 2½ out |
| Sunday, April 29 |
| » Lost to White Sox (10-7), 2-1 | Comiskey Park I (0-3) | 7-8 | Lost 3 |
| » Starters: Don Schwall vs John Buzhardt | Eighth | 3½ out |
| » Lost to White Sox (11-7), 5-1 | Comiskey Park I (0-4) | 7-9 | Lost 4 |
| » Starters: Galen Cisco vs Early Wynn | Eighth | 3½ out |
| Tuesday, May 1 |
| » Lost to Senators (3-13), 2-1 | Robert F. Kennedy Stadium (0-1) | 7-10 | Lost 5 |
| » Starters: Gene Conley vs Pete Burnside | Ninth | 4½ out |
| Thursday, May 3 |
| » Defeated Senators (3-14), 7-4 | Robert F. Kennedy Stadium (1-1) | 8-10 | |
| » Starters: Bill Monbouquette vs Jim Hannan | Ninth | 4 out |
| Friday, May 4 |
| » Defeated White Sox (12-10), 13-6 | Fenway Park (7-2) | 9-10 | Won 2 |
| » Starters: Ray Herbert vs Don Schwall | Seventh | 3½ out |
| Saturday, May 5 |
| » Defeated White Sox (12-11), 8-3 | Fenway Park (8-2) | 10-10 | Won 3 |
| » Starters: Early Wynn vs Galen Cisco | Sixth | 3½ out |
| Sunday, May 6 |
| » Defeated White Sox (12-12), 3-2 | Fenway Park (9-2) | 11-10 | Won 4 |
| » Starters: Juan Pizarro vs Gene Conley | Sixth | 3½ out |
| » Lost to White Sox (13-12), 5-3 | Fenway Park (9-3) | 11-11 | |
| » Starters: Joe Horlen vs Earl Wilson | Sixth | 3½ out |
| Future Red Sox Tom Bolton is born in Nashville, TN. |
| Wednesday, May 9 |
| » Lost to Yankees (15-7), 4-1 | Yankee Stadium (0-1) | 11-12 | Lost 2 |
| » Starters: Bill Monbouquette vs Whitey Ford | Sixth | 4½ out |
| Friday, May 11 |
| » Lost to Tigers (12-12), 5-1 | Tiger Stadium (0-1) | 11-13 | Lost 3 |
| » Starters: Don Schwall vs Paul Foytack | Eighth | 4½ out |
| Saturday, May 12 |
| » Defeated Tigers (12-13), 5-1 | Tiger Stadium (1-1) | 12-13 | |
| » Starters: Gene Conley vs Don Mossi | Seventh | 4½ out |
| Sunday, May 13 |
| » Lost to Tigers (13-13), 6-5 | Tiger Stadium (1-2) | 12-14 | |
| » Starters: Galen Cisco vs Phil Regan | Seventh | 4½ out |
| Tuesday, May 15 |
| » Defeated Yankees (16-11), 14-4 | Fenway Park (10-3) | 13-14 | |
| » Starters: Ralph Terry vs Bill Monbouquette | Sixth | 3½ out |
| Wednesday, May 16 |
| » Lost to Yankees (17-11), 9-8 | Fenway Park (10-4) | 13-15 | |
| » Starters: Bill Stafford vs Don Schwall | Seventh | 4½ out |
| Thursday, May 17 |
| » Lost to Yankees (18-11), 2-1 | Fenway Park (10-5) | 13-16 | Lost 2 |
| » Starters: Bob Turley vs Gene Conley | Seventh | 5 out |
| Friday, May 18 |
| » Lost to Angels (15-15), 8-4 | Fenway Park (10-6) | 13-17 | Lost 3 |
| » Starters: Eli Grba vs Galen Cisco | Eighth | 6 out |
| Saturday, May 19 |
| » Lost to Angels (16-15), 6-5 | Fenway Park (10-7) | 13-18 | Lost 4 |
| » Starters: Ted Bowsfield vs Earl Wilson | Eighth | 6 out |
| Sunday, May 20 |
| » Lost to Angels (17-15), 5-3 | Fenway Park (10-8) | 13-19 | Lost 5 |
| » Starters: Ken McBride vs Bill Monbouquette | Eighth | 7 out |
| » Lost to Angels (18-15), 1-0 | Fenway Park (10-9) | 13-20 | Lost 6 |
| » Starters: Bo Belinsky vs Don Schwall | Eighth | 7 out |
| Monday, May 21 |
| » Lost to Athletics (17-21), 10-5 | Fenway Park (10-10) | 13-21 | Lost 7 |
| » Starters: Jerry Walker vs Gene Conley | Ninth | 8 out |
| Tuesday, May 22 |
| » Lost to Athletics (18-21), 5-1 | Fenway Park (10-11) | 13-22 | Lost 8 |
| » Starters: Dave Wickersham vs Galen Cisco | Ninth | 8½ out |
| Wednesday, May 23 |
| » Defeated Twins (23-16), 6-1 | Fenway Park (11-11) | 14-22 | |
| » Starters: Don Lee vs Earl Wilson | Ninth | 8½ out |
| Thursday, May 24 |
| » Defeated Twins (23-17), 7-5 | Fenway Park (12-11) | 15-22 | Won 2 |
| » Starters: Joe Bonikowski vs Don Schwall | Ninth | 8½ out |
| Friday, May 25 |
| » Lost to Orioles (20-18), 9-5 | Fenway Park (12-12) | 15-23 | |
| » Starters: Chuck Estrada vs Bill Monbouquette | Eighth | 8½ out |
| Saturday, May 26 |
| » Defeated Orioles (20-19), 12-6 | Fenway Park (13-12) | 16-23 | |
| » Starters: Steve Barber vs Gene Conley | Eighth | 7½ out |
| Sunday, May 27 |
| » Lost to Orioles (21-19), 4-2 | Fenway Park (13-13) | 16-24 | |
| » Starters: Robin Roberts vs Ike Delock | Eighth | 8½ out |
| Monday, May 28 |
| » Defeated Twins (26-19), 3-0 | Metropolitan Stadium (1-0) | 17-24 | |
| » Starters: Earl Wilson vs Jack Kralick | Eighth | 7½ out |
| Tuesday, May 29 |
| » Defeated Twins (26-20), 8-5 | Metropolitan Stadium (2-0) | 18-24 | Won 2 |
| » Starters: Don Schwall vs Lee Stange | Ninth | 7 out |
| Wednesday, May 30 |
| » Lost to Angels (23-20), 10-5 | Dodger Stadium (0-1) | 18-25 | |
| » Starters: Bill Monbouquette vs Dean Chance | Ninth | 8 out |
| » Lost to Angels (24-20), 4-0 | Dodger Stadium (0-2) | 18-26 | Lost 2 |
| » Starters: Gene Conley vs Ryne Duren | Ninth | 8 out |
| Friday, June 1 |
| » Lost to Athletics (24-26), 9-2 | Municipal Stadium (0-1) | 18-27 | Lost 3 |
| » Starters: Don Schwall vs Dave Wickersham | Ninth | 9½ out |
| Saturday, June 2 |
| » Defeated Athletics (24-27), 5-2 | Municipal Stadium (1-1) | 19-27 | |
| » Starters: Earl Wilson vs Ed Rakow | Ninth | 8½ out |
| Wednesday, June 6 |
| » Defeated Tigers (26-21), 2-1 | Fenway Park (14-13) | 20-27 | Won 2 |
| » Starters: Phil Regan vs Bill Monbouquette | Ninth | 8½ out |
| » Lost to Tigers (27-21), 3-2 | Fenway Park (14-14) | 20-28 | |
| » Starters: Jim Bunning vs Gene Conley | Ninth | 8½ out |
| Thursday, June 7 |
| » Defeated Tigers (27-22), 5-4 | Fenway Park (15-14) | 21-28 | |
| » Starters: Frank Lary vs Earl Wilson | Ninth | 8½ out |
| Friday, June 8 |
| » Lost to Indians (28-21), 15-9 | Fenway Park (15-15) | 21-29 | |
| » Starters: Dick Donovan vs Ike Delock | Ninth | 9½ out |
| Saturday, June 9 |
| » Lost to Indians (29-21), 14-10 | Fenway Park (15-16) | 21-30 | Lost 2 |
| » Starters: Pedro Ramos vs Don Schwall | Eighth | 10½ out |
| Sunday, June 10 |
| » Defeated Indians (29-22), 4-3 | Fenway Park (16-16) | 22-30 | |
| » Starters: Mudcat Grant vs Bill Monbouquette | Ninth | 9½ out |
| » Lost to Indians (30-22), 9-3 | Fenway Park (16-17) | 22-31 | |
| » Starters: Barry Latman vs Gene Conley | Ninth | 9½ out |
| Monday, June 11 |
| » Lost to Indians (31-22), 10-0 | Fenway Park (16-18) | 22-32 | Lost 2 |
| » Starters: Jim Perry vs Earl Wilson | Eighth | 10 out |
| Tuesday, June 12 |
| » Defeated Orioles (28-30), 4-3 | Fenway Park (17-18) | 23-32 | |
| » Starters: Jack Fisher vs Ike Delock | Ninth | 9½ out |
| Wednesday, June 13 |
| » Defeated Orioles (28-31), 4-0 | Fenway Park (18-18) | 24-32 | Won 2 |
| » Starters: Chuck Estrada vs Don Schwall | Ninth | 9 out |
| Thursday, June 14 |
| » Lost to Orioles (29-31), 7-4 | Fenway Park (18-19) | 24-33 | |
| » Starters: Steve Barber vs Bill Monbouquette | Ninth | 9½ out |
| Friday, June 15 |
| » Defeated Tigers (28-28), 3-0 | Tiger Stadium (2-2) | 25-33 | |
| » Starters: Gene Conley vs Don Mossi | Ninth | 8½ out |
| Saturday, June 16 |
| » Defeated Tigers (28-29), 4-2 | Tiger Stadium (3-2) | 26-33 | Won 2 |
| » Starters: Earl Wilson vs Jim Bunning | Ninth | 8½ out |
| Future Red Sox Calvin Schiraldi is born in Houston, TX. |
| Sunday, June 17 |
| » Lost to Tigers (29-29), 8-5 | Tiger Stadium (3-3) | 26-34 | |
| » Starters: Don Schwall vs Paul Foytack | Ninth | 9½ out |
| » Defeated Tigers (29-30), 5-0 | Tiger Stadium (4-3) | 27-34 | |
| » Starters: Ike Delock vs Phil Regan | Ninth | 9½ out |
| Tuesday, June 19 |
| » Defeated Indians (36-25), 4-2 | Cleveland Stadium (1-1) | 28-34 | Won 2 |
| » Starters: Bill Monbouquette vs Ruben Gomez | Eighth | 8½ out |
| Wednesday, June 20 |
| » Lost to Indians (37-25), 6-3 | Cleveland Stadium (1-2) | 28-35 | |
| » Starters: Gene Conley vs Jim Perry | Ninth | 10½ out |
| » Lost to Indians (38-25), 3-0 | Cleveland Stadium (1-3) | 28-36 | Lost 2 |
| » Starters: Mike Fornieles vs Barry Latman | Ninth | 10½ out |
| Thursday, June 21 |
| » Defeated Indians (38-26), 3-1 | Cleveland Stadium (2-3) | 29-36 | |
| » Starters: Earl Wilson vs Pedro Ramos | Ninth | 9½ out |
| Friday, June 22 |
| » Defeated Orioles (33-33), 2-1 | Memorial Stadium (2-2) | 30-36 | Won 2 |
| » Starters: Ike Delock vs Milt Pappas | Ninth | 10 out |
| » Lost to Orioles (34-33), 4-3 | Memorial Stadium (2-3) | 30-37 | |
| » Starters: Don Schwall vs Robin Roberts | Ninth | 10 out |
| Saturday, June 23 |
| » Lost to Orioles (35-33), 5-3 | Memorial Stadium (2-4) | 30-38 | Lost 2 |
| » Starters: Galen Cisco vs Hal Brown | Ninth | 10 out |
| Sunday, June 24 |
| » Defeated Orioles (35-34), 3-2 | Memorial Stadium (3-4) | 31-38 | |
| » Starters: Bill Monbouquette vs Chuck Estrada | Eighth | 9 out |
| » Defeated Orioles (35-35), 8-5 | Memorial Stadium (4-4) | 32-38 | Won 2 |
| » Starters: Gene Conley vs Steve Barber | Eighth | 9 out |
| Future Red Sox Charlie Mitchell is born in Dickson, TN. |
| Tuesday, June 26 |
| » Defeated Angels (38-32), 2-0 | Fenway Park (19-19) | 33-38 | Won 3 |
| » Starters: Bo Belinsky vs Earl Wilson | Eighth | 8½ out |
| Wednesday, June 27 |
| » Lost to Angels (39-32), 3-0 | Fenway Park (19-20) | 33-39 | |
| » Starters: Don Lee vs Ike Delock | Ninth | 8½ out |
| Thursday, June 28 |
| » Lost to Angels (40-32), 19-7 | Fenway Park (19-21) | 33-40 | Lost 2 |
| » Starters: Eli Grba vs Don Schwall | Ninth | 9 out |
| Former Red Sox Cy Morgan dies in Wheeling, WV at the age of 84. |
| Friday, June 29 |
| » Defeated Athletics (35-41), 9-3 | Fenway Park (20-21) | 34-40 | |
| » Starters: Diego Segui vs Bill Monbouquette | Ninth | 8 out |
| Saturday, June 30 |
| » Defeated Athletics (35-42), 12-6 | Fenway Park (21-21) | 35-40 | Won 2 |
| » Starters: Dave Wickersham vs Gene Conley | Eighth | 7 out |
| Sunday, July 1 |
| » Lost to Athletics (36-42), 9-5 | Fenway Park (21-22) | 35-41 | |
| » Starters: Dan Pfister vs Earl Wilson | Ninth | 7 out |
| Monday, July 2 |
| » Defeated Twins (43-37), 4-3 | Fenway Park (22-22) | 36-41 | |
| » Starters: Georges Maranda vs Ike Delock | Eighth | 7 out |
| Tuesday, July 3 |
| » Lost to Twins (44-37), 4-3 | Fenway Park (22-23) | 36-42 | |
| » Starters: Jack Kralick vs Don Schwall | Eighth | 8 out |
| Former Red Sox Jimmy Walsh dies in Syracuse, NY at the age of 77. |
| Wednesday, July 4 |
| » Lost to Twins (45-37), 8-4 | Fenway Park (22-24) | 36-43 | Lost 2 |
| » Starters: Joe Bonikowski vs Bill Monbouquette | Eighth | 8½ out |
| » Defeated Twins (45-38), 9-5 | Fenway Park (23-24) | 37-43 | |
| » Starters: Jim Kaat vs Gene Conley | Eighth | 8½ out |
| Friday, July 6 |
| » Defeated Angels (45-35), 12-7 | Dodger Stadium (1-2) | 38-43 | Won 2 |
| » Starters: Earl Wilson vs Bo Belinsky | Eighth | 8½ out |
| Saturday, July 7 |
| » Defeated Angels (45-36), 5-4 | Dodger Stadium (2-2) | 39-43 | Won 3 |
| » Starters: Don Schwall vs Don Lee | Eighth | 8½ out |
| Sunday, July 8 |
| » Defeated Angels (45-37), 5-4 | Dodger Stadium (3-2) | 40-43 | Won 4 |
| » Starters: Bill Monbouquette vs Eli Grba | Eighth | 8 out |
| Thursday, July 12 |
| » Lost to Athletics (41-45), 5-4 | Municipal Stadium (1-2) | 40-44 | |
| » Starters: Gene Conley vs Dan Pfister | Eighth | 7½ out |
| » Defeated Athletics (41-46), 9-4 | Municipal Stadium (2-2) | 41-44 | |
| » Starters: Earl Wilson vs Ed Rakow | Eighth | 7½ out |
| Friday, July 13 |
| » Defeated Athletics (41-47), 11-10 | Municipal Stadium (3-2) | 42-44 | Won 2 |
| » Starters: Bill Monbouquette vs Jerry Walker | Eighth | 6½ out |
| Saturday, July 14 |
| » Defeated Athletics (41-48), 4-2 | Municipal Stadium (4-2) | 43-44 | Won 3 |
| » Starters: Arnold Earley vs Bill Fischer | Eighth | 6½ out |
| Sunday, July 15 |
| » Lost to Twins (47-43), 5-3 | Metropolitan Stadium (2-1) | 43-45 | |
| » Starters: Don Schwall vs Bill Pleis | Eighth | 8 out |
| Tuesday, July 17 |
| » Lost to Yankees (51-35), 1-0 | Fenway Park (23-25) | 43-46 | Lost 2 |
| » Starters: Ralph Terry vs Gene Conley | Eighth | 9½ out |
| Wednesday, July 18 |
| » Lost to Yankees (52-35), 12-4 | Fenway Park (23-26) | 43-47 | Lost 3 |
| » Starters: Jim Bouton vs Bill Monbouquette | Eighth | 10½ out |
| Thursday, July 19 |
| » Lost to Yankees (53-35), 10-6 | Fenway Park (23-27) | 43-48 | Lost 4 |
| » Starters: Rollie Sheldon vs Earl Wilson | Eighth | 11½ out |
| Friday, July 20 |
| » Defeated White Sox (47-49), 8-4 | Fenway Park (24-27) | 44-48 | |
| » Starters: John Buzhardt vs Don Schwall | Eighth | 11½ out |
| Saturday, July 21 |
| » Lost to White Sox (48-49), 5-0 | Fenway Park (24-28) | 44-49 | |
| » Starters: Juan Pizarro vs Gene Conley | Eighth | 12½ out |
| Sunday, July 22 |
| » Lost to White Sox (49-49), 7-3 | Fenway Park (24-29) | 44-50 | Lost 2 |
| » Starters: Ray Herbert vs Bill Monbouquette | Eighth | 12 out |
| Tuesday, July 24 |
| » Lost to Yankees (56-37), 5-3 | Yankee Stadium (0-2) | 44-51 | Lost 3 |
| » Starters: Arnold Earley vs Whitey Ford | Seventh | 13 out |
| Wednesday, July 25 |
| » Defeated Yankees (56-38), 4-2 | Yankee Stadium (1-2) | 45-51 | |
| » Starters: Earl Wilson vs Ralph Terry | Seventh | 13 out |
| » Lost to Yankees (57-38), 6-4 | Yankee Stadium (1-3) | 45-52 | |
| » Starters: Don Schwall vs Rollie Sheldon | Seventh | 13 out |
| Thursday, July 26 |
| » Lost to Yankees (58-38), 13-3 | Yankee Stadium (1-4) | 45-53 | Lost 2 |
| » Starters: Gene Conley vs Jim Bouton | Eighth | 14 out |
| Future Red Sox Jody Reed is born in Tampa, FL. |
| Friday, July 27 |
| » Lost to Senators (37-60), 11-2 | Robert F. Kennedy Stadium (1-2) | 45-54 | Lost 3 |
| » Starters: Bill Monbouquette vs Dave Stenhouse | Eighth | 15½ out |
| » Lost to Senators (38-60), 14-1 | Robert F. Kennedy Stadium (1-3) | 45-55 | Lost 4 |
| » Starters: Galen Cisco vs Don Rudolph | Eighth | 15½ out |
| Saturday, July 28 |
| » Lost to Senators (39-60), 9-1 | Robert F. Kennedy Stadium (1-4) | 45-56 | Lost 5 |
| » Starters: Arnold Earley vs Pete Burnside | Eighth | 16½ out |
| Sunday, July 29 |
| » Defeated Senators (39-61), 4-2 | Robert F. Kennedy Stadium (2-4) | 46-56 | |
| » Starters: Earl Wilson vs Tom Cheney | Eighth | 16 out |
| Wednesday, August 1 |
| » Defeated White Sox (52-54), 1-0 | Comiskey Park I (1-4) | 47-56 | Won 2 |
| » Starters: Bill Monbouquette vs Early Wynn | Eighth | 17 out |
| Thursday, August 2 |
| » Defeated White Sox (52-55), 7-4 | Comiskey Park I (2-4) | 48-56 | Won 3 |
| » Starters: Don Schwall vs Ray Herbert | Eighth | 16½ out |
| Friday, August 3 |
| » Lost to Senators (40-64), 2-1 | Fenway Park (24-30) | 48-57 | |
| » Starters: Don Rudolph vs Earl Wilson | Seventh | 17½ out |
| Saturday, August 4 |
| » Lost to Senators (41-64), 5-3 | Fenway Park (24-31) | 48-58 | Lost 2 |
| » Starters: Pete Burnside vs Gene Conley | Eighth | 17½ out |
| Future Red Sox Roger Clemens is born in Dayton, OH. |
| Sunday, August 5 |
| » Lost to Senators (42-64), 2-0 | Fenway Park (24-32) | 48-59 | Lost 3 |
| » Starters: Tom Cheney vs Bill Monbouquette | Eighth | 17 out |
| » Defeated Senators (42-65), 5-4 | Fenway Park (25-32) | 49-59 | |
| » Starters: Bennie Daniels vs Hal Kolstad | Eighth | 17 out |
| Monday, August 6 |
| » Lost to Angels (61-49), 5-2 | Fenway Park (25-33) | 49-60 | |
| » Starters: Dean Chance vs Don Schwall | Eighth | 17 out |
| Tuesday, August 7 |
| » Lost to Angels (62-49), 3-1 | Fenway Park (25-34) | 49-61 | Lost 2 |
| » Starters: Bo Belinsky vs Earl Wilson | Ninth | 18 out |
| Wednesday, August 8 |
| » Defeated Indians (55-56), 6-0 | Fenway Park (26-34) | 50-61 | |
| » Starters: Dick Donovan vs Gene Conley | Ninth | 17½ out |
| Thursday, August 9 |
| » Defeated Indians (55-57), 4-0 | Fenway Park (27-34) | 51-61 | Won 2 |
| » Starters: Barry Latman vs Bill Monbouquette | Sixth | 17 out |
| Saturday, August 11 |
| » Defeated Orioles (58-57), 3-0 | Fenway Park (28-34) | 52-61 | Won 3 |
| » Starters: Robin Roberts vs Ike Delock | Eighth | 16½ out |
| » Defeated Orioles (58-58), 7-3 | Fenway Park (29-34) | 53-61 | Won 4 |
| » Starters: Chuck Estrada vs Don Schwall | Eighth | 16½ out |
| Sunday, August 12 |
| » Defeated Orioles (58-59), 4-1 | Fenway Park (30-34) | 54-61 | Won 5 |
| » Starters: Milt Pappas vs Earl Wilson | Eighth | 16½ out |
| Monday, August 13 |
| » Lost to Angels (67-51), 5-1 | Dodger Stadium (3-3) | 54-62 | |
| » Starters: Gene Conley vs Ted Bowsfield | Eighth | 16½ out |
| Tuesday, August 14 |
| » Defeated Angels (67-52), 2-1 | Dodger Stadium (4-3) | 55-62 | |
| » Starters: Bill Monbouquette vs Dean Chance | Eighth | 16 out |
| » Defeated Angels (67-53), 9-5 | Dodger Stadium (5-3) | 56-62 | Won 2 |
| » Starters: Chet Nichols vs Eli Grba | Eighth | 16 out |
| Wednesday, August 15 |
| » Lost to Angels (68-53), 5-4 | Dodger Stadium (5-4) | 56-63 | |
| » Starters: Don Schwall vs Bo Belinsky | Seventh | 17 out |
| Friday, August 17 |
| » Lost to Twins (68-54), 7-3 | Metropolitan Stadium (2-2) | 56-64 | Lost 2 |
| » Starters: Ike Delock vs Jack Kralick | Eighth | 16 out |
| » Defeated Twins (68-55), 9-4 | Metropolitan Stadium (3-2) | 57-64 | |
| » Starters: Earl Wilson vs Georges Maranda | Eighth | 16 out |
| Saturday, August 18 |
| » Defeated Twins (68-56), 12-4 | Metropolitan Stadium (4-2) | 58-64 | Won 2 |
| » Starters: Gene Conley vs Bill Pleis | Eighth | 15½ out |
| Sunday, August 19 |
| » Lost to Twins (69-56), 4-2 | Metropolitan Stadium (4-3) | 58-65 | |
| » Starters: Bill Monbouquette vs Jim Kaat | Eighth | 17 out |
| » Lost to Twins (70-56), 7-4 | Metropolitan Stadium (4-4) | 58-66 | Lost 2 |
| » Starters: Hal Kolstad vs Lee Stange | Eighth | 17 out |
| Monday, August 20 |
| » Lost to Twins (71-56), 6-4 | Metropolitan Stadium (4-5) | 58-67 | Lost 3 |
| » Starters: Don Schwall vs Dick Stigman | Eighth | 17 out |
| Tuesday, August 21 |
| » Defeated Athletics (58-69), 11-6 | Municipal Stadium (5-2) | 59-67 | |
| » Starters: Earl Wilson vs Bill Fischer | Eighth | 17 out |
| Wednesday, August 22 |
| » Lost to Athletics (59-69), 4-2 | Municipal Stadium (5-3) | 59-68 | |
| » Starters: Ike Delock vs Moe Drabowsky | Eighth | 18 out |
| Thursday, August 23 |
| » Defeated Athletics (59-70), 8-2 | Municipal Stadium (6-3) | 60-68 | |
| » Starters: Gene Conley vs Diego Segui | Eighth | 17 out |
| Friday, August 24 |
| » Defeated Indians (60-68), 3-0 | Cleveland Stadium (3-3) | 61-68 | Won 2 |
| » Starters: Bill Monbouquette vs Pedro Ramos | Seventh | 15½ out |
| Saturday, August 25 |
| » Lost to Indians (61-68), 8-6 | Cleveland Stadium (3-4) | 61-69 | |
| » Starters: Don Schwall vs Barry Latman | Eighth | 15 out |
| Sunday, August 26 |
| » Lost to Indians (62-68), 10-5 | Cleveland Stadium (3-5) | 61-70 | Lost 2 |
| » Starters: Earl Wilson vs Jim Perry | Seventh | 15½ out |
| » Lost to Indians (63-68), 4-0 | Cleveland Stadium (3-6) | 61-71 | Lost 3 |
| » Starters: Ike Delock vs Dick Donovan | Seventh | 15½ out |
| Monday, August 27 |
| » Defeated Tigers (66-65), 7-4 | Fenway Park (31-34) | 62-71 | |
| » Starters: Hank Aguirre vs Gene Conley | Seventh | 15½ out |
| Friday, August 31 |
| » Defeated Twins (76-60), 7-5 | Fenway Park (32-34) | 63-71 | Won 2 |
| » Starters: Dick Stigman vs Bill Monbouquette | Eighth | 15 out |
| Saturday, September 1 |
| » Defeated Twins (76-61), 5-4 | Fenway Park (33-34) | 64-71 | Won 3 |
| » Starters: Jack Kralick vs Earl Wilson | Eighth | 15 out |
| Sunday, September 2 |
| » Lost to Twins (77-61), 5-2 | Fenway Park (33-35) | 64-72 | |
| » Starters: Jim Kaat vs Gene Conley | Eighth | 16 out |
| Monday, September 3 |
| » Lost to Athletics (62-76), 8-5 | Fenway Park (33-36) | 64-73 | Lost 2 |
| » Starters: Moe Drabowsky vs Ike Delock | Eighth | 16 out |
| » Defeated Athletics (62-77), 3-1 | Fenway Park (34-36) | 65-73 | |
| » Starters: Dan Pfister vs Don Schwall | Eighth | 16 out |
| Tuesday, September 4 |
| » Lost to Athletics (63-77), 7-2 | Fenway Park (34-37) | 65-74 | |
| » Starters: Ed Rakow vs Bill Monbouquette | Eighth | 16 out |
| Wednesday, September 5 |
| » Defeated Athletics (63-78), 12-4 | Fenway Park (35-37) | 66-74 | |
| » Starters: Bill Fischer vs Earl Wilson | Eighth | 15½ out |
| Friday, September 7 |
| » Lost to Yankees (84-59), 5-4 | Yankee Stadium (1-5) | 66-75 | |
| » Starters: Gene Conley vs Bill Stafford | Eighth | 17 out |
| Saturday, September 8 |
| » Lost to Yankees (85-59), 6-1 | Yankee Stadium (1-6) | 66-76 | Lost 2 |
| » Starters: Don Schwall vs Whitey Ford | Eighth | 18 out |
| Sunday, September 9 |
| » Defeated Yankees (85-60), 9-3 | Yankee Stadium (2-6) | 67-76 | |
| » Starters: Bill Monbouquette vs Hal Brown | Eighth | 16 out |
| » Defeated Yankees (85-61), 5-4 | Yankee Stadium (3-6) | 68-76 | Won 2 |
| » Starters: Ike Delock vs Jim Bouton | Eighth | 16 out |
| Monday, September 10 |
| » Lost to Orioles (72-74), 2-1 | Memorial Stadium (4-5) | 68-77 | |
| » Starters: Earl Wilson vs Robin Roberts | Eighth | 17 out |
| Wednesday, September 12 |
| » Defeated Tigers (73-72), 8-6 | Tiger Stadium (5-3) | 69-77 | |
| » Starters: Gene Conley vs Phil Regan | Eighth | 17 out |
| » Defeated Tigers (73-73), 6-2 | Tiger Stadium (6-3) | 70-77 | Won 2 |
| » Starters: Don Schwall vs Paul Foytack | Eighth | 17 out |
| » Major-league debuts: Tom Fletcher (Tigers) |
| Thursday, September 13 |
| » Lost to Tigers (74-73), 14-6 | Tiger Stadium (6-4) | 70-78 | |
| » Starters: Pete Smith vs Jim Bunning | Eighth | 17½ out |
| » Major-league debuts: Pete Smith (Red Sox) |
| Friday, September 14 |
| » Defeated Yankees (88-62), 4-1 | Fenway Park (36-37) | 71-78 | |
| » Starters: Ralph Terry vs Bill Monbouquette | Eighth | 16½ out |
| Saturday, September 15 |
| » Lost to Yankees (89-62), 9-6 | Fenway Park (36-38) | 71-79 | |
| » Starters: Bill Stafford vs Earl Wilson | Eighth | 17½ out |
| Sunday, September 16 |
| » Defeated Yankees (89-63), 4-3 | Fenway Park (37-38) | 72-79 | |
| » Starters: Whitey Ford vs Gene Conley | Seventh | 16½ out |
| Monday, September 17 |
| » Major-league debuts: Ken McMullen (Dodgers) |
| Tuesday, September 18 |
| » Defeated White Sox (79-73), 10-5 | Comiskey Park I (3-4) | 73-79 | Won 2 |
| » Starters: Don Schwall vs Early Wynn | Seventh | 16½ out |
| Wednesday, September 19 |
| » Lost to White Sox (80-73), 3-2 | Comiskey Park I (3-5) | 73-80 | |
| » Starters: Bill Monbouquette vs Eddie Fisher | Seventh | 17½ out |
| Thursday, September 20 |
| » Lost to White Sox (81-73), 6-4 | Comiskey Park I (3-6) | 73-81 | Lost 2 |
| » Starters: Earl Wilson vs Joe Horlen | Eighth | 18 out |
| » Major-league debuts: Frank Kreutzer (White Sox) |
| Friday, September 21 |
| » Defeated Senators (58-98), 4-1 | Robert F. Kennedy Stadium (3-4) | 74-81 | |
| » Starters: Gene Conley vs Carl Bouldin | Eighth | 17 out |
| Saturday, September 22 |
| » Lost to Senators (59-98), 4-3 | Robert F. Kennedy Stadium (3-5) | 74-82 | |
| » Starters: Wilbur Wood vs Bob Baird |
