| Friday, January 5 |
| Future Pirate Danny Jackson is born in San Antonio, TX. |
| Sunday, January 14 |
| Former Pirate Pep Young dies in Jamestown, NC at the age of 55. |
| Tuesday, January 23 |
| Future Pirate Benny Distefano is born in Brooklyn, NY. |
| Saturday, January 27 |
| Former Pirate Bob Steele dies in Ocala, FL at the age of 69. |
| Friday, February 2 |
| Future Pirate Pat Clements is born in McCloud, CA. |
| Sunday, February 4 |
| Future Pirate Dan Plesac is born in Gary, IN. |
| Sunday, March 18 |
| Future Pirate Brian Fisher is born in Honolulu, HI. |
| Tuesday, April 10 |
| » Defeated Phillies (1-1), 6-0 | Forbes Field (1-0) | 1-0 | |
| » Starters: Jim Owens vs Bob Friend | First | -- |
| » Major-league debuts: Howie Goss (Pirates) |
| Thursday, April 12 |
| » Major-league debuts: Larry Burright and Joe Moeller Pete Richert and Dick Tracewski (Dodgers) |
| Friday, April 13 |
| » Defeated Mets (0-2), 4-3 | Polo Grounds V (1-0) | 2-0 | Won 2 |
| » Starters: Tom Sturdivant vs Sherman Jones | Second | 1 out |
| » Major-league debuts: Ray Daviault (Mets) |
| Saturday, April 14 |
| » Defeated Mets (0-3), 6-2 | Polo Grounds V (2-0) | 3-0 | Won 3 |
| » Starters: Vinegar Bend Mizell vs Al Jackson | Second | 1 out |
| » Major-league debuts: Jim Hickman (Mets) |
| Sunday, April 15 |
| » Defeated Mets (0-4), 7-2 | Polo Grounds V (3-0) | 4-0 | Won 4 |
| » Starters: Bob Friend vs Roger Craig | First | -- |
| » Major-league debuts: Rod Kanehl (Mets) |
| Monday, April 16 |
| » Defeated Cubs (0-6), 6-5 | Wrigley Field (1-0) | 5-0 | Won 5 |
| » Starters: Bob Veale vs Glen Hobbie | First | -- |
| » Major-league debuts: Bob Veale (Pirates) |
| Tuesday, April 17 |
| » Defeated Cubs (0-7), 10-6 | Wrigley Field (2-0) | 6-0 | Won 6 |
| » Starters: Tom Sturdivant vs Jack Curtis | First | -- |
| » Major-league debuts: Jack Lamabe (Pirates) |
| Wednesday, April 18 |
| » Defeated Phillies (3-3), 4-3 | Shibe Park (1-0) | 7-0 | Won 7 |
| » Starters: Vinegar Bend Mizell vs Jack Hamilton | First | -- |
| Thursday, April 19 |
| » Defeated Phillies (3-4), 6-3 | Shibe Park (2-0) | 8-0 | Won 8 |
| » Starters: Al McBean vs Art Mahaffey | First | -- |
| Saturday, April 21 |
| » Defeated Mets (0-8), 8-4 | Forbes Field (2-0) | 9-0 | Won 9 |
| » Starters: Bob Miller vs Bob Friend | First | -- |
| Sunday, April 22 |
| » Defeated Mets (0-9), 4-3 | Forbes Field (3-0) | 10-0 | Won 10 |
| » Starters: Roger Craig vs Bob Veale | First | -- |
| Monday, April 23 |
| » Lost to Mets (1-9), 9-1 | Forbes Field (3-1) | 10-1 | |
| » Starters: Jay Hook vs Tom Sturdivant | First | -- |
| Tuesday, April 24 |
| » Defeated Giants (9-5), 7-3 | Forbes Field (4-1) | 11-1 | |
| » Starters: Juan Marichal vs Al McBean | First | -- |
| Wednesday, April 25 |
| » Lost to Giants (10-5), 8-3 | Forbes Field (4-2) | 11-2 | |
| » Starters: Gaylord Perry vs Bob Friend | First | -- |
| Friday, April 27 |
| » Lost to Dodgers (11-6), 7-2 | Dodger Stadium (0-1) | 11-3 | Lost 2 |
| » Starters: Bob Veale vs Don Drysdale | First | -- |
| Saturday, April 28 |
| » Lost to Dodgers (12-6), 2-1 | Dodger Stadium (0-2) | 11-4 | Lost 3 |
| » Starters: Earl Francis vs Sandy Koufax | Second | 1 out |
| Sunday, April 29 |
| » Defeated Dodgers (12-7), 6-1 | Dodger Stadium (1-2) | 12-4 | |
| » Starters: Bob Friend vs Johnny Podres | First | -- |
| » Defeated Dodgers (12-8), 1-0 | Dodger Stadium (2-2) | 13-4 | Won 2 |
| » Starters: Al McBean vs Joe Moeller | First | -- |
| Monday, April 30 |
| » Lost to Giants (15-5), 4-1 | Candlestick Park (0-1) | 13-5 | |
| » Starters: Vinegar Bend Mizell vs Gaylord Perry | Third | 1 out |
| Tuesday, May 1 |
| » Lost to Giants (16-5), 4-2 | Candlestick Park (0-2) | 13-6 | Lost 2 |
| » Starters: Bob Veale vs Billy O'Dell | Third | 2 out |
| Wednesday, May 2 |
| » Lost to Giants (17-5), 3-2 | Candlestick Park (0-3) | 13-7 | Lost 3 |
| » Starters: Earl Francis vs Juan Marichal | Third | 3 out |
| Thursday, May 3 |
| » Lost to Giants (18-5), 8-4 | Candlestick Park (0-4) | 13-8 | Lost 4 |
| » Starters: Al McBean vs Jack Sanford | Third | 4 out |
| Friday, May 4 |
| » Defeated Dodgers (14-10), 5-4 | Forbes Field (5-2) | 14-8 | |
| » Starters: Johnny Podres vs Bob Friend | Third | 4 out |
| Saturday, May 5 |
| » Lost to Dodgers (15-10), 10-1 | Forbes Field (5-3) | 14-9 | |
| » Starters: Don Drysdale vs Tom Sturdivant | Third | 4 out |
| Tuesday, May 8 |
| Future Pirate Orestes Destrade is born in Santiago De Cuba, Cuba. |
| Wednesday, May 9 |
| » Lost to Braves (11-14), 4-2 | County Stadium (0-1) | 14-10 | Lost 2 |
| » Starters: Bob Friend vs Ron Piche | Fourth | 5 out |
| Thursday, May 10 |
| » Lost to Braves (12-14), 4-3 | County Stadium (0-2) | 14-11 | Lost 3 |
| » Starters: Earl Francis vs Bob Hendley | Fourth | 6 out |
| Friday, May 11 |
| » Lost to Reds (14-13), 3-2 | Crosley Field (0-1) | 14-12 | Lost 4 |
| » Starters: Al McBean vs Joey Jay | Fifth | 6 out |
| Saturday, May 12 |
| » Lost to Reds (15-13), 9-2 | Crosley Field (0-2) | 14-13 | Lost 5 |
| » Starters: Vern Law vs Jim O'Toole | Sixth | 7 out |
| Sunday, May 13 |
| » Lost to Reds (16-13), 6-4 | Crosley Field (0-3) | 14-14 | Lost 6 |
| » Starters: Bob Friend vs Bob Purkey | Fifth | 8 out |
| Tuesday, May 15 |
| » Defeated Braves (14-17), 5-4 | Forbes Field (6-3) | 15-14 | |
| » Starters: Ron Piche vs Earl Francis | Fifth | 8 out |
| Wednesday, May 16 |
| » Defeated Braves (14-18), 6-0 | Forbes Field (7-3) | 16-14 | Won 2 |
| » Starters: Bob Hendley vs Al McBean | Fifth | 8 out |
| Thursday, May 17 |
| » Lost to Braves (15-18), 7-2 | Forbes Field (7-4) | 16-15 | |
| » Starters: Bob Shaw vs Bob Friend | Fifth | 8 out |
| Friday, May 18 |
| » Lost to Reds (19-14), 4-1 | Forbes Field (7-5) | 16-16 | Lost 2 |
| » Starters: Bob Purkey vs Harvey Haddix | Fifth | 8 out |
| Sunday, May 20 |
| » Defeated Reds (19-15), 8-2 | Forbes Field (8-5) | 17-16 | |
| » Starters: Joey Jay vs Vern Law | Fifth | 8 out |
| Monday, May 21 |
| » Defeated Cubs (12-25), 8-4 | Forbes Field (9-5) | 18-16 | Won 2 |
| » Starters: Dick Ellsworth vs Earl Francis | Fifth | 7 out |
| Tuesday, May 22 |
| » Lost to Cubs (13-25), 3-1 | Forbes Field (9-6) | 18-17 | |
| » Starters: Don Cardwell vs Bob Friend | Fifth | 7 out |
| Wednesday, May 23 |
| » Defeated Cardinals (23-14), 6-3 | Sportsman's Park III (1-0) | 19-17 | |
| » Starters: Harvey Haddix vs Larry Jackson | Fifth | 6 out |
| Thursday, May 24 |
| » Defeated Cardinals (23-15), 5-2 | Sportsman's Park III (2-0) | 20-17 | Won 2 |
| » Starters: Al McBean vs Ray Sadecki | Fifth | 6 out |
| Friday, May 25 |
| » Defeated Astros (16-25), 4-3 | Colt Stadium (1-0) | 21-17 | Won 3 |
| » Starters: Earl Francis vs Bob Bruce | Fifth | 6 out |
| Saturday, May 26 |
| » Lost to Astros (17-25), 2-0 | Colt Stadium (1-1) | 21-18 | |
| » Starters: Bob Friend vs Jim Golden | Fifth | 7 out |
| Sunday, May 27 |
| » Defeated Astros (17-26), 7-2 | Colt Stadium (2-1) | 22-18 | |
| » Starters: Vern Law vs Ken Johnson | Fifth | 7½ out |
| Monday, May 28 |
| » Defeated Cardinals (24-18), 3-1 | Forbes Field (10-6) | 23-18 | Won 2 |
| » Starters: Ernie Broglio vs Harvey Haddix | Fifth | 7 out |
| Tuesday, May 29 |
| » Defeated Cardinals (24-19), 7-6 | Forbes Field (11-6) | 24-18 | Won 3 |
| » Starters: Ray Sadecki vs Al McBean | Fourth | 6½ out |
| Wednesday, May 30 |
| » Defeated Cardinals (24-20), 3-1 | Forbes Field (12-6) | 25-18 | Won 4 |
| » Starters: Ray Washburn vs Earl Francis | Fourth | 7 out |
| Thursday, May 31 |
| » Defeated Cardinals (24-21), 5-4 | Forbes Field (13-6) | 26-18 | Won 5 |
| » Starters: Curt Simmons vs Bob Friend | Fourth | 6 out |
| Future Pirate Joe Orsulak is born in Glen Ridge, NJ. |
| Friday, June 1 |
| » Defeated Astros (19-28), 8-4 | Forbes Field (14-6) | 27-18 | Won 6 |
| » Starters: Jim Golden vs Joe Gibbon | Third | 6 out |
| Saturday, June 2 |
| » Defeated Astros (19-29), 9-2 | Forbes Field (15-6) | 28-18 | Won 7 |
| » Starters: Turk Farrell vs Vern Law | Fourth | 6½ out |
| Future Pirate Darnell Coles is born in San Bernardino, CA. |
| Sunday, June 3 |
| » Lost to Astros (20-29), 10-6 | Forbes Field (15-7) | 28-19 | |
| » Starters: Dave Giusti vs Harvey Haddix | Fourth | 8 out |
| » Lost to Astros (21-29), 10-3 | Forbes Field (15-8) | 28-20 | Lost 2 |
| » Starters: Ken Johnson vs Al McBean | Fourth | 8 out |
| Tuesday, June 5 |
| » Lost to Dodgers (38-17), 3-2 | Forbes Field (15-9) | 28-21 | Lost 3 |
| » Starters: Stan Williams vs Earl Francis | Fourth | 9½ out |
| » Lost to Dodgers (39-17), 8-3 | Forbes Field (15-10) | 28-22 | Lost 4 |
| » Starters: Don Drysdale vs Bob Friend | Fourth | 9½ out |
| Wednesday, June 6 |
| » Lost to Dodgers (40-17), 5-3 | Forbes Field (15-11) | 28-23 | Lost 5 |
| » Starters: Joe Moeller vs Joe Gibbon | Fourth | 9½ out |
| Thursday, June 7 |
| » Defeated Dodgers (40-18), 3-2 | Forbes Field (16-11) | 29-23 | |
| » Starters: Johnny Podres vs Harvey Haddix | Fourth | 8½ out |
| Saturday, June 9 |
| » Lost to Braves (26-29), 4-3 | County Stadium (0-3) | 29-24 | |
| » Starters: Vern Law vs Bob Shaw | Fifth | 9 out |
| » Lost to Braves (27-29), 5-3 | County Stadium (0-4) | 29-25 | Lost 2 |
| » Starters: Al McBean vs Tony Cloninger | Fifth | 9 out |
| Sunday, June 10 |
| » Defeated Braves (27-30), 12-8 | County Stadium (1-4) | 30-25 | |
| » Starters: Bob Friend vs Ron Piche | Fifth | 9 out |
| » Defeated Braves (27-31), 3-2 | County Stadium (2-4) | 31-25 | Won 2 |
| » Starters: Earl Francis vs Bob Hendley | Fifth | 9 out |
| Monday, June 11 |
| » Defeated Cubs (20-39), 6-1 | Wrigley Field (3-0) | 32-25 | Won 3 |
| » Starters: Joe Gibbon vs Don Cardwell | Fourth | 8½ out |
| Tuesday, June 12 |
| » Defeated Cubs (20-40), 4-3 | Wrigley Field (4-0) | 33-25 | Won 4 |
| » Starters: Harvey Haddix vs Glen Hobbie | Third | 7½ out |
| Wednesday, June 13 |
| » Defeated Cubs (20-41), 6-4 | Wrigley Field (5-0) | 34-25 | Won 5 |
| » Starters: Al McBean vs Cal Koonce | Third | 7½ out |
| Thursday, June 14 |
| » Defeated Cubs (20-42), 6-3 | Wrigley Field (6-0) | 35-25 | Won 6 |
| » Starters: Bob Friend vs Dick Ellsworth | Third | 6½ out |
| Friday, June 15 |
| » Defeated Braves (29-33), 9-8 | Forbes Field (17-11) | 36-25 | Won 7 |
| » Starters: Tony Cloninger vs Earl Francis | Third | 5½ out |
| Saturday, June 16 |
| » Lost to Braves (30-33), 2-1 | Forbes Field (17-12) | 36-26 | |
| » Starters: Lew Burdette vs Vern Law | Third | 5½ out |
| Sunday, June 17 |
| » Defeated Braves (30-34), 7-3 | Forbes Field (18-12) | 37-26 | |
| » Starters: Warren Spahn vs Harvey Haddix | Third | 5½ out |
| Monday, June 18 |
| » Lost to Reds (34-28), 6-5 | Forbes Field (18-13) | 37-27 | |
| » Starters: Joey Jay vs Bob Friend | Third | 7 out |
| » Lost to Reds (35-28), 4-2 | Forbes Field (18-14) | 37-28 | Lost 2 |
| » Starters: Bob Purkey vs Al McBean | Third | 7 out |
| Tuesday, June 19 |
| » Lost to Reds (36-28), 2-1 | Forbes Field (18-15) | 37-29 | Lost 3 |
| » Starters: Jim Maloney vs Earl Francis | Fourth | 8 out |
| Wednesday, June 20 |
| » Defeated Reds (36-29), 5-4 | Forbes Field (19-15) | 38-29 | |
| » Starters: Jim O'Toole vs Vern Law | Third | 7 out |
| Friday, June 22 |
| » Defeated Cubs (25-44), 7-5 | Forbes Field (20-15) | 39-29 | Won 2 |
| » Starters: Bob Anderson vs Joe Gibbon | Third | 6 out |
| Saturday, June 23 |
| » Defeated Cubs (25-45), 4-3 | Forbes Field (21-15) | 40-29 | Won 3 |
| » Starters: Don Cardwell vs Bob Friend | Third | 6 out |
| Sunday, June 24 |
| » Lost to Cubs (26-45), 4-3 | Forbes Field (21-16) | 40-30 | |
| » Starters: Bob Buhl vs Al McBean | Third | 6½ out |
| » Lost to Cubs (27-45), 8-4 | Forbes Field (21-17) | 40-31 | Lost 2 |
| » Starters: Cal Koonce vs Earl Francis | Third | 6½ out |
| Monday, June 25 |
| » Defeated Mets (19-49), 13-3 | Forbes Field (22-17) | 41-31 | |
| » Starters: Craig Anderson vs Vern Law | Third | 5½ out |
| Tuesday, June 26 |
| » Defeated Mets (19-50), 5-2 | Forbes Field (23-17) | 42-31 | Won 2 |
| » Starters: Willard Hunter vs Joe Gibbon | Third | 5 out |
| Wednesday, June 27 |
| » Defeated Mets (19-51), 6-5 | Forbes Field (24-17) | 43-31 | Won 3 |
| » Starters: Roger Craig vs Bob Friend | Third | 5 out |
| Friday, June 29 |
| » Lost to Cardinals (43-32), 5-0 | Sportsman's Park III (2-1) | 43-32 | |
| » Starters: Harvey Haddix vs Curt Simmons | Third | 5½ out |
| Saturday, June 30 |
| » Defeated Cardinals (43-33), 17-7 | Sportsman's Park III (3-1) | 44-32 | |
| » Starters: Vern Law vs Ray Washburn | Third | 5½ out |
| Sunday, July 1 |
| » Defeated Cardinals (43-34), 7-2 | Sportsman's Park III (4-1) | 45-32 | Won 2 |
| » Starters: Al McBean vs Larry Jackson | Third | 5½ out |
| Monday, July 2 |
| » Defeated Astros (32-43), 4-2 | Colt Stadium (3-1) | 46-32 | Won 3 |
| » Starters: Bob Friend vs Hal Woodeshick | Third | 5½ out |
| Tuesday, July 3 |
| » Defeated Astros (32-44), 5-2 | Colt Stadium (4-1) | 47-32 | Won 4 |
| » Starters: Harvey Haddix vs Ken Johnson | Third | 5 out |
| » Major-league debuts: Ernie Fazio (Astros) |
| Wednesday, July 4 |
| » Defeated Astros (32-45), 7-0 | Colt Stadium (5-1) | 48-32 | Won 5 |
| » Starters: Vern Law vs Bob Bruce | Third | 5 out |
| » Defeated Astros (32-46), 4-3 | Colt Stadium (6-1) | 49-32 | Won 6 |
| » Starters: Earl Francis vs Jim Golden | Third | 5 out |
| Thursday, July 5 |
| » Defeated Phillies (34-47), 5-0 | Forbes Field (25-17) | 50-32 | Won 7 |
| » Starters: Jim Owens vs Al McBean | Third | 5 out |
| Friday, July 6 |
| » Lost to Phillies (35-47), 6-2 | Forbes Field (25-18) | 50-33 | |
| » Starters: Art Mahaffey vs Bob Friend | Third | 5 out |
| Saturday, July 7 |
| » Defeated Phillies (35-48), 6-4 | Forbes Field (26-18) | 51-33 | |
| » Starters: Jack Hamilton vs Harvey Haddix | Third | 4½ out |
| Sunday, July 8 |
| » Lost to Phillies (36-48), 8-4 | Forbes Field (26-19) | 51-34 | |
| » Starters: Dennis Bennett vs Vern Law | Third | 4½ out |
| » Defeated Phillies (36-49), 6-5 | Forbes Field (27-19) | 52-34 | |
| » Starters: Bill Smith vs Earl Francis | Third | 4½ out |
| Monday, July 9 |
| Former Pirate Moose McCormick dies in Lewisburg, PA at the age of 82. |
| Thursday, July 12 |
| » Defeated Astros (33-51), 6-4 | Forbes Field (28-19) | 53-34 | Won 2 |
| » Starters: Jim Golden vs Al McBean | Third | 4½ out |
| Friday, July 13 |
| » Defeated Astros (33-52), 4-0 | Forbes Field (29-19) | 54-34 | Won 3 |
| » Starters: Turk Farrell vs Bob Friend | Third | 4½ out |
| Saturday, July 14 |
| » Defeated Astros (33-53), 4-2 | Forbes Field (30-19) | 55-34 | Won 4 |
| » Starters: Bob Bruce vs Vern Law | Third | 4½ out |
| Sunday, July 15 |
| » Lost to Cardinals (50-39), 3-2 | Forbes Field (30-20) | 55-35 | |
| » Starters: Ray Washburn vs Harvey Haddix | Third | 4½ out |
| » Defeated Cardinals (50-40), 8-7 | Forbes Field (31-20) | 56-35 | |
| » Starters: Curt Simmons vs Earl Francis | Third | 4½ out |
| Monday, July 16 |
| » Defeated Cardinals (50-41), 5-2 | Forbes Field (32-20) | 57-35 | Won 2 |
| » Starters: Ray Sadecki vs Al McBean | Third | 4 out |
| Thursday, July 19 |
| » Defeated Mets (24-65), 5-1 | Polo Grounds V (4-0) | 58-35 | Won 3 |
| » Starters: Bob Friend vs Al Jackson | Third | 2½ out |
| » Defeated Mets (24-66), 7-6 | Polo Grounds V (5-0) | 59-35 | Won 4 |
| » Starters: Tommie Sisk vs Jay Hook | Third | 2½ out |
| » Major-league debuts: Tommy Sisk (Pirates) |
| Friday, July 20 |
| » Lost to Giants (63-35), 6-3 | Forbes Field (32-21) | 59-36 | |
| » Starters: Jack Sanford vs Vern Law | Third | 3½ out |
| Saturday, July 21 |
| » Defeated Giants (63-36), 7-6 | Forbes Field (33-21) | 60-36 | |
| » Starters: Billy O'Dell vs Al McBean | Third | 3½ out |
| Sunday, July 22 |
| » Lost to Giants (64-36), 5-4 | Forbes Field (33-22) | 60-37 | |
| » Starters: Juan Marichal vs Harvey Haddix | Third | 4½ out |
| Monday, July 23 |
| » Lost to Reds (55-41), 3-0 | Crosley Field (0-4) | 60-38 | Lost 2 |
| » Starters: Bob Friend vs Jim O'Toole | Third | 5½ out |
| Tuesday, July 24 |
| » Lost to Reds (56-41), 6-4 | Crosley Field (0-5) | 60-39 | Lost 3 |
| » Starters: Earl Francis vs Joey Jay | Third | 5½ out |
| Wednesday, July 25 |
| » Lost to Reds (57-41), 13-6 | Crosley Field (0-6) | 60-40 | Lost 4 |
| » Starters: Al McBean vs Bob Purkey | Third | 6½ out |
| Future Pirate Doug Drabek is born in Victoria, TX. |
| Thursday, July 26 |
| » Lost to Reds (58-41), 5-3 | Crosley Field (0-7) | 60-41 | Lost 5 |
| » Starters: Vern Law vs Johnny Klippstein | Third | 7 out |
| Friday, July 27 |
| » Lost to Phillies (47-57), 5-3 | Shibe Park (2-1) | 60-42 | Lost 6 |
| » Starters: Harvey Haddix vs Dallas Green | Third | 7½ out |
| » Defeated Phillies (47-58), 4-1 | Shibe Park (3-1) | 61-42 | |
| » Starters: Bob Friend vs Jack Hamilton | Third | 7½ out |
| Saturday, July 28 |
| » Lost to Phillies (48-58), 9-2 | Shibe Park (3-2) | 61-43 | |
| » Starters: Earl Francis vs Art Mahaffey | Third | 8½ out |
| Sunday, July 29 |
| » Lost to Phillies (49-58), 8-1 | Shibe Park (3-3) | 61-44 | Lost 2 |
| » Starters: Al McBean vs Cal McLish | Fourth | 9½ out |
| Wednesday, August 1 |
| » Defeated Dodgers (71-36), 9-1 | Dodger Stadium (3-2) | 62-44 | |
| » Starters: Bob Friend vs Stan Williams | Fourth | 8½ out |
| Thursday, August 2 |
| » Lost to Dodgers (72-36), 5-3 | Dodger Stadium (3-3) | 62-45 | |
| » Starters: Vern Law vs Johnny Podres | Fourth | 9½ out |
| Friday, August 3 |
| » Defeated Giants (68-41), 5-2 | Candlestick Park (1-4) | 63-45 | |
| » Starters: Al McBean vs Juan Marichal | Fourth | 9½ out |
| Future Pirate Mackey Sasser is born in Fort Gaines, GA. |
| Saturday, August 4 |
| » Lost to Giants (69-41), 6-5 | Candlestick Park (1-5) | 63-46 | |
| » Starters: Harvey Haddix vs Jack Sanford | Fourth | 10½ out |
| Sunday, August 5 |
| » Lost to Giants (70-41), 2-1 | Candlestick Park (1-6) | 63-47 | Lost 2 |
| » Starters: Bob Friend vs Billy O'Dell | Fourth | 11 out |
| Tuesday, August 7 |
| » Lost to Cardinals (63-50), 5-0 | Forbes Field (33-23) | 63-48 | Lost 3 |
| » Starters: Ernie Broglio vs Joe Gibbon | Fourth | 12½ out |
| Wednesday, August 8 |
| » Lost to Cardinals (64-50), 2-0 | Forbes Field (33-24) | 63-49 | Lost 4 |
| » Starters: Bob Gibson vs Al McBean | Fourth | 13½ out |
| Friday, August 10 |
| » Lost to Cubs (43-73), 7-6 | Wrigley Field (6-1) | 63-50 | Lost 5 |
| » Starters: Bob Friend vs Don Cardwell | Fifth | 14 out |
| Saturday, August 11 |
| » Defeated Cubs (43-74), 10-6 | Wrigley Field (7-1) | 64-50 | |
| » Starters: Vern Law vs Dick Ellsworth | Fourth | 13 out |
| Sunday, August 12 |
| » Defeated Cubs (43-75), 5-4 | Wrigley Field (8-1) | 65-50 | Won 2 |
| » Starters: Harvey Haddix vs Cal Koonce | Fourth | 12 out |
| Tuesday, August 14 |
| » Defeated Dodgers (79-41), 2-1 | Forbes Field (34-24) | 66-50 | Won 3 |
| » Starters: Johnny Podres vs Al McBean | Fourth | 11 out |
| Wednesday, August 15 |
| » Defeated Dodgers (79-42), 6-3 | Forbes Field (35-24) | 67-50 | Won 4 |
| » Starters: Don Drysdale vs Bob Friend | Fourth | 10 out |
| Thursday, August 16 |
| » Lost to Dodgers (80-42), 7-3 | Forbes Field (35-25) | 67-51 | |
| » Starters: Stan Williams vs Joe Gibbon | Fourth | 11 out |
| Friday, August 17 |
| » Defeated Phillies (57-67), 9-1 | Forbes Field (36-25) | 68-51 | |
| » Starters: Jack Hamilton vs Harvey Haddix | Fourth | 11 out |
| Saturday, August 18 |
| » Defeated Phillies (57-68), 5-2 | Forbes Field (37-25) | 69-51 | Won 2 |
| » Starters: Cal McLish vs Tom Sturdivant | Fourth | 10 out |
| Sunday, August 19 |
| » Lost to Phillies (58-68), 3-2 | Forbes Field (37-26) | 69-52 | |
| » Starters: Dennis Bennett vs Vern Law | Fourth | 11 out |
| Monday, August 20 |
| » Defeated Mets (30-93), 2-0 | Polo Grounds V (6-0) | 70-52 | |
| » Starters: Bob Friend vs Jay Hook | Fourth | 9½ out |
| » Defeated Mets (30-94), 6-3 | Polo Grounds V (7-0) | 71-52 | Won 2 |
| » Starters: Al McBean vs Bob Miller | Fourth | 9½ out |
| Tuesday, August 21 |
| » Defeated Mets (30-95), 8-6 | Polo Grounds V (8-0) | 72-52 | Won 3 |
| » Starters: Joe Gibbon vs Craig Anderson | Fourth | 9½ out |
| » Lost to Mets (31-95), 5-4 | Polo Grounds V (8-1) | 72-53 | |
| » Starters: Harvey Haddix vs Bob Moorhead | Fourth | 9½ out |
| Wednesday, August 22 |
| » Defeated Astros (45-81), 3-0 | Forbes Field (38-26) | 73-53 | |
| » Starters: George Brunet vs Tom Sturdivant | Fourth | 8½ out |
| Thursday, August 23 |
| » Defeated Astros (45-82), 4-0 | Forbes Field (39-26) | 74-53 | Won 2 |
| » Starters: Ken Johnson vs Vern Law | Fourth | 8½ out |
| Saturday, August 25 |
| » Lost to Cardinals (70-58), 3-2 | Sportsman's Park III (4-2) | 74-54 | |
| » Starters: Bob Friend vs Larry Jackson | Fourth | 8½ out |
| » Defeated Cardinals (70-59), 4-0 | Sportsman's Park III (5-2) | 75-54 | |
| » Starters: Earl Francis vs Curt Simmons | Fourth | 8½ out |
| » Major-league debuts: Bob Burda (Cardinals) |
| Sunday, August 26 |
| » Lost to Cardinals (71-59), 6-5 | Sportsman's Park III (5-3) | 75-55 | |
| » Starters: Harvey Haddix vs Ray Washburn | Fourth | 9 out |
| » Defeated Cardinals (71-60), 7-6 | Sportsman's Park III (6-3) | 76-55 | |
| » Starters: Tom Sturdivant vs Lindy McDaniel | Fourth | 9 out |
| Tuesday, August 28 |
| » Defeated Cubs (49-83), 7-6 | Forbes Field (40-26) | 77-55 | Won 2 |
| » Starters: Bob Buhl vs Vern Law | Fourth | 9 out |
| Wednesday, August 29 |
| » Defeated Cubs (49-84), 5-2 | Forbes Field (41-26) | 78-55 | Won 3 |
| » Starters: Cal Koonce vs Bob Friend | Fourth | 9 out |
| Thursday, August 30 |
| » Defeated Cubs (49-85), 5-3 | Forbes Field (42-26) | 79-55 | Won 4 |
| » Starters: Don Cardwell vs Al McBean | Fourth | 8 out |
| Friday, August 31 |
| » Lost to Phillies (66-73), 3-2 | Shibe Park (3-4) | 79-56 | |
| » Starters: Earl Francis vs Dallas Green | Fourth | 9 out |
| Saturday, September 1 |
| » Defeated Phillies (66-74), 7-6 | Shibe Park (4-4) | 80-56 | |
| » Starters: Tom Sturdivant vs Jim Owens | Fourth | 9 out |
| Monday, September 3 |
| » Defeated Mets (35-104), 2-0 | Forbes Field (43-26) | 81-56 | Won 2 |
| » Starters: Jay Hook vs Bob Friend | Fourth | 8 out |
| » Defeated Mets (35-105), 5-4 | Forbes Field (44-26) | 82-56 | Won 3 |
| » Starters: Roger Craig vs Al McBean | Fourth | 8 out |
| Future Pirate Dave Clark is born in Tupelo, MS. |
| Tuesday, September 4 |
| » Defeated Mets (35-106), 5-1 | Forbes Field (45-26) | 83-56 | Won 4 |
| » Starters: Craig Anderson vs Harvey Haddix | Fourth | 8 out |
| Wednesday, September 5 |
| » Lost to Astros (52-87), 5-3 | Colt Stadium (6-2) | 83-57 | |
| » Starters: Vern Law vs George Brunet | Fourth | 8 out |
| » Major-league debuts: Dave Roberts (Astros) |
| Thursday, September 6 |
| » Lost to Astros (53-87), 4-3 | Colt Stadium (6-3) | 83-58 | Lost 2 |
| » Starters: Tom Sturdivant vs Ken Johnson | Fourth | 8 out |
| Friday, September 7 |
| » Defeated Dodgers (91-51), 10-1 | Dodger Stadium (4-3) | 84-58 | |
| » Starters: Earl Francis vs Stan Williams | Fourth | 7 out |
| Saturday, September 8 |
| » Lost to Dodgers (92-51), 6-1 | Dodger Stadium (4-4) | 84-59 | |
| » Starters: Al McBean vs Pete Richert | Fourth | 8 out |
| » Major-league debuts: Tom Butters and Elmo Plaskett (Pirates) |
| Sunday, September 9 |
| » Lost to Dodgers (93-51), 5-3 | Dodger Stadium (4-5) | 84-60 | Lost 2 |
| » Starters: Bob Friend vs Johnny Podres | Fourth | 9 out |
| Monday, September 10 |
| » Lost to Giants (93-51), 4-1 | Candlestick Park (1-7) | 84-61 | Lost 3 |
| » Starters: Harvey Haddix vs Billy O'Dell | Fourth | 10 out |
| Tuesday, September 11 |
| » Lost to Giants (94-51), 2-0 | Candlestick Park (1-8) | 84-62 | Lost 4 |
| » Starters: Tom Sturdivant vs Jack Sanford | Fourth | 11 out |
| Thursday, September 13 |
| » Major-league debuts: Pete Smith (Red Sox) |
| Friday, September 14 |
| » Defeated Giants (94-54), 5-1 | Forbes Field (46-26) | 85-62 | |
| » Starters: Billy O'Dell vs Earl Francis | Fourth | 11½ out |
| » Major-league debuts: Bob Bailey (Pirates) |
| Saturday, September 15 |
| » Defeated Giants (94-55), 5-1 | Forbes Field (47-26) | 86-62 | Won 2 |
| » Starters: Jack Sanford vs Bob Friend | Fourth | 11½ out |
| Sunday, September 16 |
| » Defeated Giants (94-56), 6-4 | Forbes Field (48-26) | 87-62 | Won 3 |
| » Starters: Gaylord Perry vs Al McBean | Fourth | 10½ out |
| » Major-league debuts: Willie Stargell (Pirates) |
| Monday, September 17 |
| » Defeated Giants (94-57), 5-2 | Forbes Field (49-26) | 88-62 | Won 4 |
| » Starters: Mike McCormick vs Tom Sturdivant | Fourth | 9½ out |
| Tuesday, September 18 |
| » Lost to Reds (94-59), 7-4 | Forbes Field (49-27) | 88-63 | |
| » Starters: Jim O'Toole vs Earl Francis | Fourth | 9½ out |
| Wednesday, September 19 |
| » Defeated Reds (94-60), 1-0 | Forbes Field (50-27) | 89-63 | |
| » Starters: Jim Maloney vs Bob Friend | Fourth | 9½ out |
| Thursday, September 20 |
| » Defeated Reds (94-61), 4-3 | Forbes Field (51-27) | |
