| Saturday, January 13 |
| Future Indian Kevin Mitchell is born in San Diego, CA. |
| Friday, January 26 |
| Former Indian Steve O'Neill dies in Cleveland, OH at the age of 71. |
| Saturday, January 27 |
| Former Indian Joe Vosmik dies in Cleveland, OH at the age of 52. |
| Saturday, February 10 |
| Former Indian Roy Walker dies in New Orleans, LA at the age of 69. |
| Monday, February 19 |
| Future Indian Alvaro Espinoza is born in Valencia, Venezuela. |
| Monday, March 26 |
| Future Indian Kevin Seitzer is born in Springfield, IL. |
| Tuesday, April 10 |
| » Defeated Red Sox (0-1), 4-0 | Fenway Park (1-0) | 1-0 | |
| » Starters: Dick Donovan vs Don Schwall | First | -- |
| Wednesday, April 11 |
| » Lost to Red Sox (1-1), 4-0 | Fenway Park (1-1) | 1-1 | |
| » Starters: Ron Taylor vs Bill Monbouquette | Second | ½ out |
| » Major-league debuts: Ron Taylor (Indians) |
| Friday, April 13 |
| » Lost to Senators (2-0), 5-2 | Cleveland Stadium (0-1) | 1-2 | Lost 2 |
| » Starters: Pete Burnside vs Barry Latman | Fourth | 1½ out |
| Saturday, April 14 |
| » Defeated Senators (2-1), 6-4 | Cleveland Stadium (1-1) | 2-2 | |
| » Starters: Claude Osteen vs Gary Bell | Third | ½ out |
| Sunday, April 15 |
| » Major-league debuts: Bob Tillman (Red Sox) |
| Monday, April 16 |
| » Major-league debuts: Hank Fischer (Braves) |
| Tuesday, April 17 |
| » Defeated Red Sox (2-4), 5-0 | Cleveland Stadium (2-1) | 3-2 | Won 2 |
| » Starters: Bill Monbouquette vs Dick Donovan | Third | ½ out |
| Saturday, April 21 |
| » Lost to Yankees (5-2), 3-1 | Yankee Stadium (0-1) | 3-3 | |
| » Starters: Barry Latman vs Whitey Ford | Fourth | 1½ out |
| » Major-league debuts: Doc Edwards (Indians) |
| Sunday, April 22 |
| » Defeated Yankees (5-3), 7-5 | Yankee Stadium (1-1) | 4-3 | |
| » Starters: Dick Donovan vs Bill Stafford | First | -- |
| » Defeated Yankees (5-4), 9-3 | Yankee Stadium (2-1) | 5-3 | Won 2 |
| » Starters: Sam McDowell vs Jim Coates | First | -- |
| » Major-league debuts: Jim Bouton (Yankees) |
| Tuesday, April 24 |
| » Defeated Angels (5-6), 3-2 | Dodger Stadium (1-0) | 6-3 | Won 3 |
| » Starters: Ron Taylor vs Dean Chance | First | -- |
| Wednesday, April 25 |
| » Lost to Angels (6-6), 6-2 | Dodger Stadium (1-1) | 6-4 | |
| » Starters: Pedro Ramos vs Bo Belinsky | First | -- |
| Thursday, April 26 |
| » Defeated Angels (6-7), 6-4 | Dodger Stadium (2-1) | 7-4 | |
| » Starters: Gary Bell vs Eli Grba | First | -- |
| Friday, April 27 |
| » Defeated Twins (7-8), 7-2 | Cleveland Stadium (3-1) | 8-4 | Won 2 |
| » Starters: Jim Kaat vs Dick Donovan | First | -- |
| Saturday, April 28 |
| » Defeated Twins (7-9), 8-7 | Cleveland Stadium (4-1) | 9-4 | Won 3 |
| » Starters: Jim Manning vs Ron Taylor | First | -- |
| Sunday, April 29 |
| » Lost to Twins (8-9), 8-4 | Cleveland Stadium (4-2) | 9-5 | |
| » Starters: Jack Kralick vs Pedro Ramos | Third | 1 out |
| » Lost to Twins (9-9), 7-3 | Cleveland Stadium (4-3) | 9-6 | Lost 2 |
| » Starters: Don Lee vs Gary Bell | Third | 1 out |
| Tuesday, May 1 |
| » Lost to Angels (8-9), 8-6 | Cleveland Stadium (4-4) | 9-7 | Lost 3 |
| » Starters: Bo Belinsky vs Sam McDowell | Fourth | 2 out |
| Friday, May 4 |
| » Defeated Athletics (11-12), 6-5 | Municipal Stadium (1-0) | 10-7 | |
| » Starters: Dick Donovan vs Dan Pfister | Second | 1½ out |
| Saturday, May 5 |
| » Lost to Athletics (12-12), 18-6 | Municipal Stadium (1-1) | 10-8 | |
| » Starters: Ron Taylor vs Jerry Walker | Second | 2 out |
| » Defeated Athletics (12-13), 5-2 | Municipal Stadium (2-1) | 11-8 | |
| » Starters: Jim Perry vs Art Ditmar | Second | 2 out |
| Sunday, May 6 |
| » Defeated Athletics (12-14), 5-1 | Municipal Stadium (3-1) | 12-8 | Won 2 |
| » Starters: Mudcat Grant vs Norm Bass | Second | 1½ out |
| Tuesday, May 8 |
| » Defeated Twins (14-11), 6-3 | Metropolitan Stadium (1-0) | 13-8 | Won 3 |
| » Starters: Dick Donovan vs Jim Kaat | Second | 1 out |
| Wednesday, May 9 |
| » Lost to Twins (15-11), 2-1 | Metropolitan Stadium (1-1) | 13-9 | |
| » Starters: Gary Bell vs Jack Kralick | Second | 2 out |
| Thursday, May 10 |
| » Defeated Twins (15-12), 9-4 | Metropolitan Stadium (2-1) | 14-9 | |
| » Starters: Jim Perry vs Don Lee | Second | 1½ out |
| Friday, May 11 |
| » Defeated Yankees (15-8), 7-1 | Cleveland Stadium (5-4) | 15-9 | Won 2 |
| » Starters: Ralph Terry vs Mudcat Grant | Second | ½ out |
| Saturday, May 12 |
| » Lost to Yankees (16-8), 9-6 | Cleveland Stadium (5-5) | 15-10 | |
| » Starters: Bill Stafford vs Sam McDowell | Second | 1½ out |
| Sunday, May 13 |
| » Defeated Yankees (16-9), 6-4 | Cleveland Stadium (6-5) | 16-10 | |
| » Starters: Whitey Ford vs Dick Donovan | First | -- |
| » Defeated Yankees (16-10), 8-5 | Cleveland Stadium (7-5) | 17-10 | Won 2 |
| » Starters: Jim Bouton vs Gary Bell | First | -- |
| Tuesday, May 15 |
| » Lost to Athletics (14-18), 6-5 | Cleveland Stadium (7-6) | 17-11 | |
| » Starters: Ed Rakow vs Jim Perry | First | -- |
| Wednesday, May 16 |
| » Defeated Athletics (14-19), 10-9 | Cleveland Stadium (8-6) | 18-11 | |
| » Starters: Jerry Walker vs Mudcat Grant | First | -- |
| Friday, May 18 |
| » Defeated Tigers (13-16), 9-2 | Cleveland Stadium (9-6) | 19-11 | Won 2 |
| » Starters: Paul Foytack vs Dick Donovan | First | -- |
| Saturday, May 19 |
| » Lost to Tigers (14-16), 9-3 | Cleveland Stadium (9-7) | 19-12 | |
| » Starters: Don Mossi vs Jim Perry | First | -- |
| Sunday, May 20 |
| » Defeated Tigers (14-17), 7-6 | Cleveland Stadium (10-7) | 20-12 | |
| » Starters: Phil Regan vs Pedro Ramos | First | -- |
| » Lost to Tigers (15-17), 8-6 | Cleveland Stadium (10-8) | 20-13 | |
| » Starters: Frank Lary vs Sam McDowell | First | -- |
| Monday, May 21 |
| » Defeated Orioles (18-17), 10-7 | Cleveland Stadium (11-8) | 21-13 | |
| » Starters: Hal Brown vs Mudcat Grant | First | -- |
| Tuesday, May 22 |
| » Lost to Orioles (19-17), 4-1 | Cleveland Stadium (11-9) | 21-14 | |
| » Starters: Milt Pappas vs Jim Perry | Third | ½ out |
| Wednesday, May 23 |
| » Defeated White Sox (20-19), 5-4 | Comiskey Park I (1-0) | 22-14 | |
| » Starters: Dick Donovan vs Juan Pizarro | Second | ½ out |
| Friday, May 25 |
| » Defeated Senators (10-27), 2-1 | Robert F. Kennedy Stadium (1-0) | 23-14 | Won 2 |
| » Starters: Pedro Ramos vs Claude Osteen | First | -- |
| Saturday, May 26 |
| » Lost to Senators (11-27), 8-6 | Robert F. Kennedy Stadium (1-1) | 23-15 | |
| » Starters: Mudcat Grant vs Dave Stenhouse | First | -- |
| Sunday, May 27 |
| » Defeated Senators (11-28), 5-3 | Robert F. Kennedy Stadium (2-1) | 24-15 | |
| » Starters: Jim Perry vs Bennie Daniels | First | -- |
| Monday, May 28 |
| » Lost to White Sox (22-22), 2-0 | Cleveland Stadium (11-10) | 24-16 | |
| » Starters: Early Wynn vs Dick Donovan | First | -- |
| Wednesday, May 30 |
| » Defeated Orioles (21-22), 7-0 | Memorial Stadium (1-0) | 25-16 | |
| » Starters: Pedro Ramos vs Chuck Estrada | First | -- |
| » Lost to Orioles (22-22), 7-0 | Memorial Stadium (1-1) | 25-17 | |
| » Starters: Barry Latman vs Hal Brown | First | -- |
| Thursday, May 31 |
| » Defeated Orioles (22-23), 4-3 | Memorial Stadium (2-1) | 26-17 | |
| » Starters: Mudcat Grant vs Robin Roberts | First | -- |
| Friday, June 1 |
| » Defeated Tigers (24-20), 7-1 | Tiger Stadium (1-0) | 27-17 | Won 2 |
| » Starters: Jim Perry vs Frank Lary | First | -- |
| Saturday, June 2 |
| » Lost to Tigers (25-20), 5-3 | Tiger Stadium (1-1) | 27-18 | |
| » Starters: Dick Donovan vs Jim Bunning | First | -- |
| Sunday, June 3 |
| » Lost to Tigers (26-20), 8-6 | Tiger Stadium (1-2) | 27-19 | Lost 2 |
| » Starters: Pedro Ramos vs Don Mossi | First | -- |
| Wednesday, June 6 |
| » Lost to Yankees (28-19), 5-0 | Yankee Stadium (2-2) | 27-20 | Lost 3 |
| » Starters: Mudcat Grant vs Ralph Terry | Second | 1 out |
| Thursday, June 7 |
| » Lost to Yankees (29-19), 4-0 | Yankee Stadium (2-3) | 27-21 | Lost 4 |
| » Starters: Jim Perry vs Bill Stafford | Third | 2 out |
| Friday, June 8 |
| » Defeated Red Sox (21-29), 15-9 | Fenway Park (2-1) | 28-21 | |
| » Starters: Dick Donovan vs Ike Delock | Third | 2 out |
| Saturday, June 9 |
| » Defeated Red Sox (21-30), 14-10 | Fenway Park (3-1) | 29-21 | Won 2 |
| » Starters: Pedro Ramos vs Don Schwall | Second | 2 out |
| Sunday, June 10 |
| » Lost to Red Sox (22-30), 4-3 | Fenway Park (3-2) | 29-22 | |
| » Starters: Mudcat Grant vs Bill Monbouquette | Third | 1 out |
| » Defeated Red Sox (22-31), 9-3 | Fenway Park (4-2) | 30-22 | |
| » Starters: Barry Latman vs Gene Conley | Third | 1 out |
| Monday, June 11 |
| » Defeated Red Sox (22-32), 10-0 | Fenway Park (5-2) | 31-22 | Won 2 |
| » Starters: Jim Perry vs Earl Wilson | Second | 2½ out |
| Tuesday, June 12 |
| Future Indian Darrel Akerfelds is born in Denver, CO. |
| Wednesday, June 13 |
| » Lost to Senators (20-36), 4-2 | Robert F. Kennedy Stadium (2-2) | 31-23 | |
| » Starters: Pedro Ramos vs Claude Osteen | Third | ½ out |
| » Defeated Senators (20-37), 4-1 | Robert F. Kennedy Stadium (3-2) | 32-23 | |
| » Starters: Dick Donovan vs Dave Stenhouse | Third | ½ out |
| Thursday, June 14 |
| » Lost to Senators (21-37), 4-3 | Robert F. Kennedy Stadium (3-3) | 32-24 | |
| » Starters: Barry Latman vs Tom Cheney | Third | 1 out |
| Friday, June 15 |
| » Defeated Yankees (32-23), 3-0 | Cleveland Stadium (12-10) | 33-24 | |
| » Starters: Ralph Terry vs Mudcat Grant | Third | 1 out |
| Saturday, June 16 |
| » Defeated Yankees (32-24), 10-9 | Cleveland Stadium (13-10) | 34-24 | Won 2 |
| » Starters: Rollie Sheldon vs Jim Perry | First | -- |
| Sunday, June 17 |
| » Defeated Yankees (32-25), 6-1 | Cleveland Stadium (14-10) | 35-24 | Won 3 |
| » Starters: Bill Stafford vs Dick Donovan | First | -- |
| » Defeated Yankees (32-26), 6-3 | Cleveland Stadium (15-10) | 36-24 | Won 4 |
| » Starters: Jim Coates vs Pedro Ramos | First | -- |
| Tuesday, June 19 |
| » Lost to Red Sox (28-34), 4-2 | Cleveland Stadium (15-11) | 36-25 | |
| » Starters: Bill Monbouquette vs Ruben Gomez | First | -- |
| Wednesday, June 20 |
| » Defeated Red Sox (28-35), 6-3 | Cleveland Stadium (16-11) | 37-25 | |
| » Starters: Gene Conley vs Jim Perry | First | -- |
| » Defeated Red Sox (28-36), 3-0 | Cleveland Stadium (17-11) | 38-25 | Won 2 |
| » Starters: Mike Fornieles vs Barry Latman | First | -- |
| Thursday, June 21 |
| » Lost to Red Sox (29-36), 3-1 | Cleveland Stadium (17-12) | 38-26 | |
| » Starters: Earl Wilson vs Pedro Ramos | First | -- |
| Friday, June 22 |
| » Defeated Senators (22-43), 6-2 | Cleveland Stadium (18-12) | 39-26 | |
| » Starters: Bennie Daniels vs Dick Donovan | First | -- |
| Saturday, June 23 |
| » Lost to Senators (23-43), 5-3 | Cleveland Stadium (18-13) | 39-27 | |
| » Starters: Dave Stenhouse vs Mudcat Grant | First | -- |
| Sunday, June 24 |
| » Lost to Senators (24-43), 3-1 | Cleveland Stadium (18-14) | 39-28 | Lost 2 |
| » Starters: Claude Osteen vs Jim Perry | First | -- |
| » Defeated Senators (24-44), 4-2 | Cleveland Stadium (19-14) | 40-28 | |
| » Starters: Pete Burnside vs Barry Latman | First | -- |
| Tuesday, June 26 |
| » Lost to Tigers (34-34), 6-0 | Tiger Stadium (1-3) | 40-29 | |
| » Starters: Pedro Ramos vs Jim Bunning | First | -- |
| » Defeated Tigers (34-35), 3-1 | Tiger Stadium (2-3) | 41-29 | |
| » Starters: Bob Hartman vs Sam Jones | First | -- |
| Wednesday, June 27 |
| » Lost to Tigers (35-35), 4-0 | Tiger Stadium (2-4) | 41-30 | |
| » Starters: Dick Donovan vs Paul Foytack | First | -- |
| Friday, June 29 |
| » Lost to White Sox (37-39), 3-2 | Comiskey Park I (1-1) | 41-31 | Lost 2 |
| » Starters: Jim Perry vs Ray Herbert | First | -- |
| Saturday, June 30 |
| » Lost to White Sox (38-39), 7-0 | Comiskey Park I (1-2) | 41-32 | Lost 3 |
| » Starters: Mudcat Grant vs Early Wynn | First | -- |
| Future Indian Tony Fernandez is born in San Pedro de Macoris, D.R. |
| Sunday, July 1 |
| » Lost to White Sox (39-39), 5-4 | Comiskey Park I (1-3) | 41-33 | Lost 4 |
| » Starters: Pedro Ramos vs John Buzhardt | Third | 1½ out |
| » Lost to White Sox (40-39), 7-6 | Comiskey Park I (1-4) | 41-34 | Lost 5 |
| » Starters: Bob Hartman vs Juan Pizarro | Third | 1½ out |
| Monday, July 2 |
| » Defeated Orioles (39-39), 2-0 | Cleveland Stadium (20-14) | 42-34 | |
| » Starters: Steve Barber vs Dick Donovan | Third | 1½ out |
| Former Indian Josh Clarke dies in Ventura, CA at the age of 84. |
| Wednesday, July 4 |
| » Defeated Tigers (40-37), 1-0 | Cleveland Stadium (21-14) | 43-34 | Won 2 |
| » Starters: Hank Aguirre vs Jim Perry | Third | ½ out |
| » Defeated Tigers (40-38), 6-2 | Cleveland Stadium (22-14) | 44-34 | Won 3 |
| » Starters: Don Mossi vs Barry Latman | Third | ½ out |
| Thursday, July 5 |
| » Defeated Tigers (40-39), 7-6 | Cleveland Stadium (23-14) | 45-34 | Won 4 |
| » Starters: Frank Lary vs Pedro Ramos | First | -- |
| Friday, July 6 |
| » Defeated White Sox (41-44), 5-3 | Cleveland Stadium (24-14) | 46-34 | Won 5 |
| » Starters: Early Wynn vs Ruben Gomez | First | -- |
| Saturday, July 7 |
| » Defeated White Sox (41-45), 5-3 | Cleveland Stadium (25-14) | 47-34 | Won 6 |
| » Starters: Eddie Fisher vs Dick Donovan | First | -- |
| Sunday, July 8 |
| » Lost to White Sox (42-45), 6-3 | Cleveland Stadium (25-15) | 47-35 | |
| » Starters: Juan Pizarro vs Jim Perry | Second | 2 out |
| » Lost to White Sox (43-45), 8-4 | Cleveland Stadium (25-16) | 47-36 | Lost 2 |
| » Starters: Ray Herbert vs Pedro Ramos | Second | 2 out |
| Thursday, July 12 |
| » Defeated Orioles (42-44), 6-4 | Memorial Stadium (3-1) | 48-36 | |
| » Starters: Ruben Gomez vs Robin Roberts | Second | 2 out |
| Friday, July 13 |
| » Lost to Orioles (43-44), 10-3 | Memorial Stadium (3-2) | 48-37 | |
| » Starters: Jim Perry vs Steve Barber | Second | 2 out |
| Saturday, July 14 |
| » Lost to Orioles (44-44), 4-3 | Memorial Stadium (3-3) | 48-38 | Lost 2 |
| » Starters: Dick Donovan vs Milt Pappas | Second | 2 out |
| Sunday, July 15 |
| » Lost to Orioles (45-44), 6-4 | Cleveland Stadium (25-17) | 48-39 | Lost 3 |
| » Starters: Chuck Estrada vs Mudcat Grant | Third | 3 out |
| » Lost to Orioles (46-44), 6-5 | Cleveland Stadium (25-18) | 48-40 | Lost 4 |
| » Starters: Jack Fisher vs Pedro Ramos | Third | 3 out |
| Tuesday, July 17 |
| » Lost to Twins (48-43), 7-2 | Metropolitan Stadium (2-2) | 48-41 | Lost 5 |
| » Starters: Gary Bell vs Camilo Pascual | Third | 4½ out |
| Wednesday, July 18 |
| » Lost to Twins (49-43), 14-3 | Metropolitan Stadium (2-3) | 48-42 | Lost 6 |
| » Starters: Barry Latman vs Dick Stigman | Fourth | 5½ out |
| Thursday, July 19 |
| » Lost to Twins (50-43), 8-0 | Metropolitan Stadium (2-4) | 48-43 | Lost 7 |
| » Starters: Dick Donovan vs Jim Kaat | Fourth | 6½ out |
| Friday, July 20 |
| » Lost to Angels (52-40), 8-5 | Dodger Stadium (2-2) | 48-44 | Lost 8 |
| » Starters: Sam McDowell vs Ted Bowsfield | Fourth | 7½ out |
| Saturday, July 21 |
| » Lost to Angels (53-40), 4-0 | Dodger Stadium (2-3) | 48-45 | Lost 9 |
| » Starters: Pedro Ramos vs Ken McBride | Fourth | 8½ out |
| Sunday, July 22 |
| » Defeated Angels (53-41), 7-3 | Dodger Stadium (3-3) | 49-45 | |
| » Starters: Jim Perry vs Don Lee | Fourth | 7 out |
| Tuesday, July 24 |
| » Defeated Athletics (43-56), 5-4 | Municipal Stadium (4-1) | 50-45 | Won 2 |
| » Starters: Dick Donovan vs Bob Giggie | Fourth | 7 out |
| Wednesday, July 25 |
| » Lost to Athletics (44-56), 5-4 | Municipal Stadium (4-2) | 50-46 | |
| » Starters: Sam McDowell vs Diego Segui | Fourth | 7½ out |
| Friday, July 27 |
| » Lost to Twins (55-45), 2-1 | Cleveland Stadium (25-19) | 50-47 | Lost 2 |
| » Starters: Camilo Pascual vs Jim Perry | Fourth | 9 out |
| Saturday, July 28 |
| » Lost to Twins (56-45), 5-2 | Cleveland Stadium (25-20) | 50-48 | Lost 3 |
| » Starters: Jim Kaat vs Barry Latman | Fifth | 10 out |
| Sunday, July 29 |
| » Defeated Twins (56-46), 3-2 | Cleveland Stadium (26-20) | 51-48 | |
| » Starters: Dick Stigman vs Dick Donovan | Fifth | 10 out |
| » Lost to Twins (57-46), 7-5 | Cleveland Stadium (26-21) | 51-49 | |
| » Starters: Jack Kralick vs Ruben Gomez | Fifth | 10 out |
| Tuesday, July 31 |
| » Defeated Angels (57-46), 5-3 | Cleveland Stadium (27-21) | 52-49 | |
| » Starters: Eli Grba vs Jim Perry | Fourth | 10 out |
| Wednesday, August 1 |
| » Lost to Angels (58-46), 2-1 | Cleveland Stadium (27-22) | 52-50 | |
| » Starters: Dean Chance vs Barry Latman | Fifth | 12 out |
| » Lost to Angels (59-46), 8-4 | Cleveland Stadium (27-23) | 52-51 | Lost 2 |
| » Starters: Ted Bowsfield vs Sam McDowell | Fifth | 12 out |
| Thursday, August 2 |
| » Lost to Angels (60-46), 5-4 | Cleveland Stadium (27-24) | 52-52 | Lost 3 |
| » Starters: Bo Belinsky vs Mudcat Grant | Fifth | 12½ out |
| Friday, August 3 |
| » Defeated Athletics (46-62), 1-0 | Cleveland Stadium (28-24) | 53-52 | |
| » Starters: Bill Fischer vs Dick Donovan | Fourth | 12½ out |
| Saturday, August 4 |
| » Lost to Athletics (47-62), 8-3 | Cleveland Stadium (28-25) | 53-53 | |
| » Starters: Diego Segui vs Jim Perry | Fifth | 12½ out |
| Future Indian John Farrell is born in Monmouth Beach, NJ. |
| Sunday, August 5 |
| » Lost to Athletics (48-62), 3-2 | Cleveland Stadium (28-26) | 53-54 | Lost 2 |
| » Starters: Dan Pfister vs Barry Latman | Fifth | 13 out |
| » Lost to Athletics (49-62), 5-2 | Cleveland Stadium (28-27) | 53-55 | Lost 3 |
| » Starters: Orlando Pena vs Pedro Ramos | Fifth | 13 out |
| Monday, August 6 |
| » Defeated Tigers (52-56), 6-5 | Cleveland Stadium (29-27) | 54-55 | |
| » Starters: Hank Aguirre vs Sam McDowell | Fifth | 12 out |
| Tuesday, August 7 |
| » Defeated Tigers (52-57), 4-2 | Cleveland Stadium (30-27) | 55-55 | Won 2 |
| » Starters: Jim Bunning vs Mudcat Grant | Fifth | 12 out |
| Wednesday, August 8 |
| » Lost to Red Sox (50-61), 6-0 | Fenway Park (5-3) | 55-56 | |
| » Starters: Dick Donovan vs Gene Conley | Fifth | 12½ out |
| Thursday, August 9 |
| » Lost to Red Sox (51-61), 4-0 | Fenway Park (5-4) | 55-57 | Lost 2 |
| » Starters: Barry Latman vs Bill Monbouquette | Fifth | 13 out |
| Friday, August 10 |
| » Defeated Senators (42-71), 3-0 | Robert F. Kennedy Stadium (4-3) | 56-57 | |
| » Starters: Pedro Ramos vs Dave Stenhouse | Sixth | 13 out |
| Saturday, August 11 |
| » Lost to Senators (43-71), 9-2 | Robert F. Kennedy Stadium (4-4) | 56-58 | |
| » Starters: Sam McDowell vs Claude Osteen | Sixth | 13½ out |
| Sunday, August 12 |
| » Defeated Senators (43-72), 5-3 | Robert F. Kennedy Stadium (5-4) | 57-58 | |
| » Starters: Mudcat Grant vs Steve Hamilton | Fifth | 13½ out |
| Monday, August 13 |
| » Lost to Senators (44-72), 11-2 | Cleveland Stadium (30-28) | 57-59 | |
| » Starters: Jim Hannan vs Dick Donovan | Sixth | 14 out |
| » Lost to Senators (45-72), 3-2 | Cleveland Stadium (30-29) | 57-60 | Lost 2 |
| » Starters: Don Rudolph vs Barry Latman | Sixth | 14 out |
| Tuesday, August 14 |
| » Lost to White Sox (61-58), 9-0 | Cleveland Stadium (30-30) | 57-61 | Lost 3 |
| » Starters: Frank Baumann vs Pedro Ramos | Seventh | 15 out |
| Wednesday, August 15 |
| » Lost to White Sox (62-58), 10-2 | Cleveland Stadium (30-31) | 57-62 | Lost 4 |
| » Starters: Juan Pizarro vs Sam McDowell | Sixth | 15½ out |
| » Defeated White Sox (62-59), 3-2 | Cleveland Stadium (31-31) | 58-62 | |
| » Starters: Early Wynn vs Jim Perry | Sixth | 15½ out |
| Thursday, August 16 |
| » Lost to White Sox (63-59), 11-6 | Cleveland Stadium (31-32) | 58-63 | |
| » Starters: Eddie Fisher vs Mudcat Grant | Seventh | 15½ out |
| Friday, August 17 |
| » Lost to Orioles (59-62), 5-2 | Memorial Stadium (3-4) | 58-64 | Lost 2 |
| » Starters: Dick Donovan vs Milt Pappas | Seventh | 15½ out |
| Saturday, August 18 |
| » Defeated Orioles (59-63), 4-3 | Memorial Stadium (4-4) | 59-64 | |
| » Starters: Pedro Ramos vs Chuck Estrada | Seventh | 15 out |
| Sunday, August 19 |
| » Lost to Orioles (60-63), 6-5 | Memorial Stadium (4-5) | 59-65 | |
| » Starters: Barry Latman vs Jack Fisher | Seventh | 16 out |
| Tuesday, August 21 |
| » Lost to Tigers (62-62), 10-1 | Tiger Stadium (2-5) | 59-66 | Lost 2 |
| » Starters: Jim Perry vs Jim Bunning | Seventh | 16½ out |
| Wednesday, August 22 |
| » Defeated Tigers (62-63), 7-3 | Tiger Stadium (3-5) | 60-66 | |
| » Starters: Dick Donovan vs Ron Kline | Seventh | 16½ out |
| Thursday, August 23 |
| » Lost to Tigers (63-63), 8-5 | Tiger Stadium (3-6) | 60-67 | |
| » Starters: Mudcat Grant vs Hank Aguirre | Seventh | 16½ out |
| Friday, August 24 |
| » Lost to Red Sox (61-68), 3-0 | Cleveland Stadium (31-33) | 60-68 | Lost 2 |
| » Starters: Bill Monbouquette vs Pedro Ramos | Eighth | 16 out |
| Saturday, August 25 |
| » Defeated Red Sox (61-69), 8-6 | Cleveland Stadium (32-33) | 61-68 | |
| » Starters: Don Schwall vs Barry Latman | Seventh | 14½ out |
| Future Indian Oddibe McDowell is born in Hollywood, FL. |
| Sunday, August 26 |
| » Defeated Red Sox (61-70), 10-5 | Cleveland Stadium (33-33) | 62-68 | Won 2 |
| » Starters: Earl Wilson vs Jim Perry | Sixth | 13 out |
| » Defeated Red Sox (61-71), 4-0 | Cleveland Stadium (34-33) | 63-68 | Won 3 |
| » Starters: Ike Delock vs Dick Donovan | Sixth | 13 out |
| Monday, August 27 |
| » Lost to Yankees (77-55), 5-0 | Yankee Stadium (2-4) | 63-69 | |
| » Starters: Sam McDowell vs Ralph Terry | Sixth | 14 out |
| Tuesday, August 28 |
| » Lost to Yankees (78-55), 2-1 | Yankee Stadium (2-5) | 63-70 | Lost 2 |
| » Starters: Mudcat Grant vs Bill Stafford | Seventh | 15 out |
| Wednesday, August 29 |
| » Defeated Yankees (78-56), 3-2 | Yankee Stadium (3-5) | 64-70 | |
| » Starters: Pedro Ramos vs Jim Coates | Seventh | 13 out |
| » Defeated Yankees (78-57), 9-5 | Yankee Stadium (4-5) | 65-70 | Won 2 |
| » Starters: Barry Latman vs Jim Bouton | Seventh | 13 out |
| Friday, August 31 |
| » Defeated Orioles (67-68), 9-6 | Cleveland Stadium (35-33) | 66-70 | Won 3 |
| » Starters: Robin Roberts vs Dick Donovan | Seventh | 13 out |
| Saturday, September 1 |
| » Lost to Orioles (68-68), 8-2 | Cleveland Stadium (35-34) | 66-71 | |
| » Starters: Jack Fisher vs Sam McDowell | Seventh | 14 out |
| Sunday, September 2 |
| » Lost to Orioles (69-68), 4-1 | Cleveland Stadium (35-35) | 66-72 | Lost 2 |
| » Starters: Milt Pappas vs Mudcat Grant | Seventh | 15½ out |
| » Lost to Orioles (70-68), 2-1 | Cleveland Stadium (35-36) | 66-73 | Lost 3 |
| » Starters: Hal Brown vs Jim Perry | Seventh | 15½ out |
| Monday, September 3 |
| » Defeated White Sox (70-68), 4-3 | Comiskey Park I (2-4) | 67-73 | |
| » Starters: Pedro Ramos vs Early Wynn | Seventh | 14½ out |
| » Defeated White Sox (70-69), 6-5 | Comiskey Park I (3-4) | 68-73 | Won 2 |
| » Starters: Barry Latman vs Joe Horlen | Seventh | 14½ out |
| Future Indian Dave Clark is born in Tupelo, MS. |
| Tuesday, September 4 |
| » Lost to White Sox (71-69), 3-2 | Comiskey Park I (3-5) | 68-74 | |
| » Starters: Dick Donovan vs John Buzhardt | Seventh | 14½ out |
| Wednesday, September 5 |
| » Lost to White Sox (72-69), 2-1 | Comiskey Park I (3-6) | 68-75 | Lost 2 |
| » Starters: Mudcat Grant vs Ray Herbert | Seventh | 15 out |
| Friday, September 7 |
| » Defeated Athletics (63-79), 2-1 | Cleveland Stadium (36-36) | 69-75 | |
| » Starters: Orlando Pena vs Pedro Ramos | Seventh | 15½ out |
| Saturday, September 8 |
| » Defeated Athletics (63-80), 3-2 | Cleveland Stadium (37-36) | 70-75 | Won 2 |
| » Starters: Dan Pfister vs Barry Latman | Seventh | 15½ out |
| Sunday, September 9 |
| » Defeated Athletics (63-81), 12-7 | Cleveland Stadium (38-36) | 71-75 | Won 3 |
| » Starters: Ed Rakow vs Dick Donovan | Seventh | 14 out |
| Tuesday, September 11 |
| » Defeated Senators (56-92), 3-0 | Cleveland Stadium (39-36) | 72-75 | Won 4 |
| » Starters: Claude Osteen vs Jim Perry | Seventh | 14½ out |
| » Major-league debuts: Max Alvis (Indians) |
| Wednesday, September 12 |
| » Lost to Yankees (88-61), 5-2 | Cleveland Stadium (39-37) | 72-76 | |
| » Starters: Whitey Ford vs Pedro Ramos | Seventh | 15½ out |
| Thursday, September 13 |
| » Major-league debuts: Pete Smith (Red Sox) |
| Friday, September 14 |
| » Lost to Twins (84-66), 11-1 | Metropolitan Stadium (2-5) | 72-77 | Lost 2 |
| » Starters: Dick Donovan vs Dick Stigman | Seventh | 15½ out |
| » Major-league debuts: Tommie Agee (Indians) |
| Saturday, September 15 |
| » Lost to Twins (85-66), 12-2 | Metropolitan Stadium (2-6) | 72-78 | Lost 3 |
| » Starters: Barry Latman vs Jim Kaat | Seventh | 16½ out |
| Sunday, September 16 |
| » Lost to Twins (86-66), 4-3 | Metropolitan Stadium (2-7) | 72-79 | Lost 4 |
| » Starters: Mudcat Grant vs Camilo Pascual | Seventh | 16½ out |
| Monday, September 17 |
| » Major-league debuts: Ken McMullen (Dodgers) |
| Tuesday, September 18 |
| » Lost to Athletics (69-82), 6-1 | Municipal Stadium (4-3) | 72-80 | Lost 5 |
| » Starters: Jim Perry vs Dan Pfister | Eighth | 17½ out |
| Wednesday, September 19 |
| » Defeated Athletics (69-83), 10-9 | Municipal Stadium (5-3) | 73-80 | |
| » Starters: Dick Donovan vs Ed Rakow | Seventh | 17½ out |
| Thursday, September 20 |
| » Defeated Athletics (69-84), 5-2 | Municipal Stadium (6-3) | 74-80 | Won 2 |
| » Starters: Pedro Ramos vs Bill Fischer | Seventh | 17 out |
| Friday, September 21 |
| » Defeated Angels (83-71), 9-6 | Dodger Stadium (4-3) | 75-80 | Won 3 |
| » Starters: Mudcat Grant vs Don Lee | Seventh | 16 out |
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