| Saturday, January 13 |
| Future Athletic Kevin Mitchell is born in San Diego, CA. |
| Monday, January 22 |
| Former Athletic Lefty Russell dies in Baltimore, MD at the age of 72. |
| Saturday, February 3 |
| Future Athletic Joe Klink is born in Johnstown, PA. |
| Sunday, February 25 |
| Former Athletic Tink Turner dies in Philadelphia, PA at the age of 73. |
| Friday, March 2 |
| Future Athletic Terry Steinbach is born in New Ulm, MN. |
| Monday, March 26 |
| Future Athletic Kevin Seitzer is born in Springfield, IL. |
| Thursday, March 29 |
| Future Athletic Billy Beane is born in Orlando, FL. |
| Tuesday, April 10 |
| » Defeated Twins (0-1), 4-2 | Municipal Stadium (1-0) | 1-0 | |
| » Starters: Jack Kralick vs Ed Rakow | First | -- |
| » Major-league debuts: Bernie Allen (Twins) |
| Wednesday, April 11 |
| » Lost to Twins (1-1), 8-0 | Municipal Stadium (1-1) | 1-1 | |
| » Starters: Camilo Pascual vs John Wyatt | Second | ½ out |
| Thursday, April 12 |
| » Lost to Twins (2-1), 9-5 | Municipal Stadium (1-2) | 1-2 | Lost 2 |
| » Starters: Don Lee vs Norm Bass | Fourth | 1 out |
| » Major-league debuts: Diego Segui (Athletics) |
| Friday, April 13 |
| » Lost to White Sox (2-1), 12-5 | Municipal Stadium (1-3) | 1-3 | Lost 3 |
| » Starters: Ray Herbert vs Art Ditmar | Fifth | 2 out |
| Saturday, April 14 |
| » Defeated White Sox (2-2), 7-3 | Municipal Stadium (2-3) | 2-3 | |
| » Starters: John Buzhardt vs Jerry Walker | Fourth | 1 out |
| Sunday, April 15 |
| » Lost to White Sox (3-2), 8-3 | Municipal Stadium (2-4) | 2-4 | |
| » Starters: Juan Pizarro vs Ed Rakow | Seventh | 2 out |
| Monday, April 16 |
| » Major-league debuts: Hank Fischer (Braves) |
| Tuesday, April 17 |
| » Defeated Angels (3-2), 5-3 | Dodger Stadium (1-0) | 3-4 | |
| » Starters: John Wyatt vs Ken McBride | Fifth | 1½ out |
| Wednesday, April 18 |
| » Lost to Angels (4-2), 3-2 | Dodger Stadium (1-1) | 3-5 | |
| » Starters: Norm Bass vs Bo Belinsky | Sixth | 2½ out |
| » Major-league debuts: Bo Belinsky (Angels) |
| Thursday, April 19 |
| » Lost to Angels (5-2), 6-4 | Dodger Stadium (1-2) | 3-6 | Lost 2 |
| » Starters: Art Ditmar vs Dean Chance | Eighth | 3½ out |
| Friday, April 20 |
| » Defeated White Sox (6-3), 7-4 | Comiskey Park I (1-0) | 4-6 | |
| » Starters: Jerry Walker vs Juan Pizarro | Eighth | 2½ out |
| Saturday, April 21 |
| » Defeated White Sox (6-4), 9-6 | Comiskey Park I (2-0) | 5-6 | Won 2 |
| » Starters: John Wyatt vs Early Wynn | Sixth | 2 out |
| Sunday, April 22 |
| » Defeated White Sox (6-5), 7-1 | Comiskey Park I (3-0) | 6-6 | Won 3 |
| » Starters: Ed Rakow vs Ray Herbert | Fourth | 2½ out |
| » Defeated White Sox (6-6), 7-5 | Comiskey Park I (4-0) | 7-6 | Won 4 |
| » Starters: Norm Bass vs Joe Horlen | Fourth | 2½ out |
| » Major-league debuts: Dave DeBusschere (White Sox) |
| Tuesday, April 24 |
| » Lost to Tigers (5-4), 1-0 | Tiger Stadium (0-1) | 7-7 | |
| » Starters: Dan Pfister vs Don Mossi | Sixth | 2½ out |
| Wednesday, April 25 |
| » Defeated Tigers (5-5), 9-8 | Tiger Stadium (1-1) | 8-7 | |
| » Starters: Jerry Walker vs Doug Gallagher | Fourth | 2½ out |
| Thursday, April 26 |
| » Lost to Tigers (6-5), 11-7 | Tiger Stadium (1-2) | 8-8 | |
| » Starters: John Wyatt vs Frank Lary | Sixth | 2½ out |
| Friday, April 27 |
| » Defeated Orioles (7-7), 14-5 | Municipal Stadium (3-4) | 9-8 | |
| » Starters: Art Quirk vs Ed Rakow | Fifth | 2½ out |
| Saturday, April 28 |
| » Lost to Orioles (8-7), 3-2 | Municipal Stadium (3-5) | 9-9 | |
| » Starters: Steve Barber vs Norm Bass | Seventh | 2½ out |
| Sunday, April 29 |
| » Lost to Orioles (9-7), 8-3 | Municipal Stadium (3-6) | 9-10 | Lost 2 |
| » Starters: Milt Pappas vs Dan Pfister | Seventh | 3 out |
| Tuesday, May 1 |
| » Lost to Tigers (9-6), 3-2 | Municipal Stadium (3-7) | 9-11 | Lost 3 |
| » Starters: Jim Bunning vs Jerry Walker | Eighth | 4 out |
| Wednesday, May 2 |
| » Defeated Tigers (9-7), 12-8 | Municipal Stadium (4-7) | 10-11 | |
| » Starters: Don Mossi vs Norm Bass | Sixth | 4 out |
| Thursday, May 3 |
| » Defeated Tigers (9-8), 6-4 | Municipal Stadium (5-7) | 11-11 | Won 2 |
| » Starters: Doug Gallagher vs Ed Rakow | Seventh | 3 out |
| Friday, May 4 |
| » Lost to Indians (10-7), 6-5 | Municipal Stadium (5-8) | 11-12 | |
| » Starters: Dick Donovan vs Dan Pfister | Sixth | 3½ out |
| Saturday, May 5 |
| » Defeated Indians (10-8), 18-6 | Municipal Stadium (6-8) | 12-12 | |
| » Starters: Ron Taylor vs Jerry Walker | Seventh | 4 out |
| » Lost to Indians (11-8), 5-2 | Municipal Stadium (6-9) | 12-13 | |
| » Starters: Jim Perry vs Art Ditmar | Seventh | 4 out |
| Sunday, May 6 |
| » Lost to Indians (12-8), 5-1 | Municipal Stadium (6-10) | 12-14 | Lost 2 |
| » Starters: Mudcat Grant vs Norm Bass | Seventh | 4½ out |
| Wednesday, May 9 |
| » Lost to Orioles (11-12), 6-3 | Memorial Stadium (0-1) | 12-15 | Lost 3 |
| » Starters: Ed Rakow vs Milt Pappas | Seventh | 5½ out |
| Thursday, May 10 |
| » Lost to Orioles (12-12), 5-2 | Memorial Stadium (0-2) | 12-16 | Lost 4 |
| » Starters: Jerry Walker vs Chuck Estrada | Eighth | 6 out |
| Former Athletic Lefty Willis dies in Bethesda, MD at the age of 57. |
| Friday, May 11 |
| » Defeated Twins (15-13), 5-3 | Metropolitan Stadium (1-0) | 13-16 | |
| » Starters: Dan Pfister vs Camilo Pascual | Ninth | 5 out |
| Saturday, May 12 |
| » Lost to Twins (16-13), 5-4 | Metropolitan Stadium (1-1) | 13-17 | |
| » Starters: Art Ditmar vs Lee Stange | Eighth | 6 out |
| Sunday, May 13 |
| » Lost to Twins (17-13), 10-3 | Metropolitan Stadium (1-2) | 13-18 | Lost 2 |
| » Starters: Norm Bass vs Joe Bonikowski | Eighth | 6 out |
| Tuesday, May 15 |
| » Defeated Indians (17-11), 6-5 | Cleveland Stadium (1-0) | 14-18 | |
| » Starters: Ed Rakow vs Jim Perry | Seventh | 5 out |
| Wednesday, May 16 |
| » Lost to Indians (18-11), 10-9 | Cleveland Stadium (1-1) | 14-19 | |
| » Starters: Jerry Walker vs Mudcat Grant | Eighth | 6 out |
| Friday, May 18 |
| » Lost to Senators (8-21), 3-2 | Robert F. Kennedy Stadium (0-1) | 14-20 | Lost 2 |
| » Starters: Dan Pfister vs Pete Burnside | Ninth | 7 out |
| Saturday, May 19 |
| » Defeated Senators (8-22), 8-4 | Robert F. Kennedy Stadium (1-1) | 15-20 | |
| » Starters: Art Ditmar vs Don Rudolph | Seventh | 6 out |
| Sunday, May 20 |
| » Defeated Senators (8-23), 1-0 | Robert F. Kennedy Stadium (2-1) | 16-20 | Won 2 |
| » Starters: Ed Rakow vs Claude Osteen | Seventh | 6 out |
| » Lost to Senators (9-23), 7-5 | Robert F. Kennedy Stadium (2-2) | 16-21 | |
| » Starters: Jim Archer vs Tom Cheney | Seventh | 6 out |
| Monday, May 21 |
| » Defeated Red Sox (13-21), 10-5 | Fenway Park (1-0) | 17-21 | |
| » Starters: Jerry Walker vs Gene Conley | Eighth | 6 out |
| Tuesday, May 22 |
| » Defeated Red Sox (13-22), 5-1 | Fenway Park (2-0) | 18-21 | Won 2 |
| » Starters: Dave Wickersham vs Galen Cisco | Eighth | 5½ out |
| Wednesday, May 23 |
| » Lost to Yankees (22-13), 13-7 | Yankee Stadium (0-1) | 18-22 | |
| » Starters: Dan Pfister vs Ralph Terry | Eighth | 6½ out |
| Thursday, May 24 |
| » Lost to Yankees (23-13), 9-4 | Yankee Stadium (0-2) | 18-23 | Lost 2 |
| » Starters: Ed Rakow vs Bud Daley | Eighth | 7½ out |
| Friday, May 25 |
| » Lost to Angels (20-17), 5-4 | Municipal Stadium (6-11) | 18-24 | Lost 3 |
| » Starters: Ken McBride vs Norm Bass | Seventh | 7½ out |
| Saturday, May 26 |
| » Defeated Angels (20-18), 8-7 | Municipal Stadium (7-11) | 19-24 | |
| » Starters: Dean Chance vs Jerry Walker | Seventh | 6½ out |
| Sunday, May 27 |
| » Defeated Angels (20-19), 3-2 | Municipal Stadium (8-11) | 20-24 | Won 2 |
| » Starters: Jim Donohue vs Dave Wickersham | Seventh | 7 out |
| » Lost to Angels (21-19), 6-3 | Municipal Stadium (8-12) | 20-25 | |
| » Starters: Eli Grba vs Dan Pfister | Seventh | 7 out |
| Tuesday, May 29 |
| » Defeated Yankees (24-17), 2-1 | Municipal Stadium (9-12) | 21-25 | |
| » Starters: Jim Bouton vs John Wyatt | Eighth | 6 out |
| Wednesday, May 30 |
| » Lost to Senators (13-29), 8-0 | Municipal Stadium (9-13) | 21-26 | |
| » Starters: Claude Osteen vs Ed Rakow | Eighth | 6 out |
| » Defeated Senators (13-30), 5-2 | Municipal Stadium (10-13) | 22-26 | |
| » Starters: Tom Cheney vs Norm Bass | Eighth | 6 out |
| Thursday, May 31 |
| » Defeated Senators (13-31), 1-0 | Municipal Stadium (11-13) | 23-26 | Won 2 |
| » Starters: Steve Hamilton vs Jerry Walker | Eighth | 6 out |
| Friday, June 1 |
| » Defeated Red Sox (18-27), 9-2 | Municipal Stadium (12-13) | 24-26 | Won 3 |
| » Starters: Don Schwall vs Dave Wickersham | Seventh | 6 out |
| Saturday, June 2 |
| » Lost to Red Sox (19-27), 5-2 | Municipal Stadium (12-14) | 24-27 | |
| » Starters: Earl Wilson vs Ed Rakow | Eighth | 6 out |
| Sunday, June 3 |
| Former Athletic Arthur Stokes dies in Titusville, PA at the age of 66. |
| Tuesday, June 5 |
| » Defeated Twins (29-23), 4-3 | Metropolitan Stadium (2-2) | 25-27 | |
| » Starters: John Wyatt vs Camilo Pascual | Sixth | 5 out |
| Wednesday, June 6 |
| » Lost to Twins (30-23), 7-0 | Metropolitan Stadium (2-3) | 25-28 | |
| » Starters: Jerry Walker vs Jim Kaat | Seventh | 6 out |
| Thursday, June 7 |
| » Lost to Twins (31-23), 5-2 | Metropolitan Stadium (2-4) | 25-29 | Lost 2 |
| » Starters: Dave Wickersham vs Joe Bonikowski | Eighth | 7 out |
| Friday, June 8 |
| » Lost to Angels (27-24), 7-1 | Dodger Stadium (1-3) | 25-30 | Lost 3 |
| » Starters: Ed Rakow vs Don Lee | Eighth | 8 out |
| Saturday, June 9 |
| » Lost to Angels (28-24), 8-1 | Dodger Stadium (1-4) | 25-31 | Lost 4 |
| » Starters: John Wyatt vs Dean Chance | Seventh | 9 out |
| Sunday, June 10 |
| » Lost to Angels (29-24), 14-6 | Dodger Stadium (1-5) | 25-32 | Lost 5 |
| » Starters: Jerry Walker vs Ken McBride | Eighth | 9 out |
| » Lost to Angels (30-24), 6-5 | Dodger Stadium (1-6) | 25-33 | Lost 6 |
| » Starters: Norm Bass vs Bo Belinsky | Eighth | 9 out |
| Tuesday, June 12 |
| » Defeated White Sox (29-30), 2-1 | Municipal Stadium (13-14) | 26-33 | |
| » Starters: Juan Pizarro vs Dave Wickersham | Eighth | 8½ out |
| Future Athletic Darrel Akerfelds is born in Denver, CO. |
| Wednesday, June 13 |
| » Defeated White Sox (29-31), 4-3 | Municipal Stadium (14-14) | 27-33 | Won 2 |
| » Starters: John Buzhardt vs Ed Rakow | Eighth | 8 out |
| Thursday, June 14 |
| » Defeated White Sox (29-32), 11-8 | Municipal Stadium (15-14) | 28-33 | Won 3 |
| » Starters: Joe Horlen vs John Wyatt | Eighth | 7½ out |
| Friday, June 15 |
| » Defeated Twins (36-26), 6-1 | Municipal Stadium (16-14) | 29-33 | Won 4 |
| » Starters: Camilo Pascual vs Jerry Walker | Eighth | 6½ out |
| Saturday, June 16 |
| » Defeated Twins (36-27), 6-2 | Municipal Stadium (17-14) | 30-33 | Won 5 |
| » Starters: Joe Bonikowski vs Diego Segui | Eighth | 6½ out |
| Sunday, June 17 |
| » Defeated Twins (36-28), 10-6 | Municipal Stadium (18-14) | 31-33 | Won 6 |
| » Starters: Jack Kralick vs Dave Wickersham | Seventh | 7 out |
| Monday, June 18 |
| » Lost to Twins (37-28), 9-4 | Municipal Stadium (18-15) | 31-34 | |
| » Starters: Camilo Pascual vs Ed Rakow | Seventh | 7½ out |
| Tuesday, June 19 |
| » Lost to Angels (34-28), 7-4 | Municipal Stadium (18-16) | 31-35 | Lost 2 |
| » Starters: Ken McBride vs John Wyatt | Seventh | 7½ out |
| Wednesday, June 20 |
| » Lost to Angels (35-28), 5-1 | Municipal Stadium (18-17) | 31-36 | Lost 3 |
| » Starters: Ted Bowsfield vs Jerry Walker | Eighth | 9 out |
| Thursday, June 21 |
| » Lost to Angels (36-28), 3-1 | Municipal Stadium (18-18) | 31-37 | Lost 4 |
| » Starters: Bo Belinsky vs Diego Segui | Eighth | 9 out |
| Friday, June 22 |
| » Lost to White Sox (34-35), 5-1 | Comiskey Park I (4-1) | 31-38 | Lost 5 |
| » Starters: Dan Pfister vs Joe Horlen | Eighth | 10 out |
| Saturday, June 23 |
| » Lost to White Sox (35-35), 6-1 | Comiskey Park I (4-2) | 31-39 | Lost 6 |
| » Starters: Ed Rakow vs Juan Pizarro | Eighth | 10 out |
| Sunday, June 24 |
| » Lost to White Sox (36-35), 6-1 | Comiskey Park I (4-3) | 31-40 | Lost 7 |
| » Starters: Jerry Walker vs Ray Herbert | Ninth | 10 out |
| » Defeated White Sox (36-36), 5-2 | Comiskey Park I (5-3) | 32-40 | |
| » Starters: Diego Segui vs Early Wynn | Ninth | 10 out |
| Tuesday, June 26 |
| » Defeated Senators (24-45), 2-1 | Robert F. Kennedy Stadium (3-2) | 33-40 | Won 2 |
| » Starters: Dan Pfister vs Tom Cheney | Ninth | 9½ out |
| Wednesday, June 27 |
| » Defeated Senators (24-46), 4-1 | Robert F. Kennedy Stadium (4-2) | 34-40 | Won 3 |
| » Starters: Ed Rakow vs Steve Hamilton | Eighth | 8½ out |
| Thursday, June 28 |
| » Defeated Senators (24-47), 10-7 | Robert F. Kennedy Stadium (5-2) | 35-40 | Won 4 |
| » Starters: Jerry Walker vs Bennie Daniels | Eighth | 8 out |
| Former Athletic Mickey Cochrane dies in Lake Forest, IL at the age of 60. |
| Friday, June 29 |
| » Lost to Red Sox (34-40), 9-3 | Fenway Park (2-1) | 35-41 | |
| » Starters: Diego Segui vs Bill Monbouquette | Eighth | 8 out |
| Saturday, June 30 |
| » Lost to Red Sox (35-40), 12-6 | Fenway Park (2-2) | 35-42 | Lost 2 |
| » Starters: Dave Wickersham vs Gene Conley | Ninth | 8 out |
| Sunday, July 1 |
| » Defeated Red Sox (35-41), 9-5 | Fenway Park (3-2) | 36-42 | |
| » Starters: Dan Pfister vs Earl Wilson | Eighth | 7 out |
| Monday, July 2 |
| » Lost to Yankees (41-32), 8-4 | Yankee Stadium (0-3) | 36-43 | |
| » Starters: Ed Rakow vs Bill Stafford | Ninth | 8 out |
| Tuesday, July 3 |
| » Lost to Yankees (42-32), 8-7 | Yankee Stadium (0-4) | 36-44 | Lost 2 |
| » Starters: Jerry Walker vs Whitey Ford | Ninth | 9 out |
| Wednesday, July 4 |
| » Defeated Yankees (42-33), 11-1 | Yankee Stadium (1-4) | 37-44 | |
| » Starters: Diego Segui vs Rollie Sheldon | Ninth | 9½ out |
| » Lost to Yankees (43-33), 7-3 | Yankee Stadium (1-5) | 37-45 | |
| » Starters: Dan Pfister vs Bob Turley | Ninth | 9½ out |
| Friday, July 6 |
| » Defeated Senators (26-52), 12-9 | Municipal Stadium (19-18) | 38-45 | |
| » Starters: Tom Cheney vs Ed Rakow | Ninth | 9½ out |
| Saturday, July 7 |
| » Defeated Senators (26-53), 9-8 | Municipal Stadium (20-18) | 39-45 | Won 2 |
| » Starters: Pete Burnside vs Jerry Walker | Ninth | 9½ out |
| Sunday, July 8 |
| » Defeated Senators (26-54), 6-5 | Municipal Stadium (21-18) | 40-45 | Won 3 |
| » Starters: Don Rudolph vs Diego Segui | Ninth | 9 out |
| Thursday, July 12 |
| » Defeated Red Sox (40-44), 5-4 | Municipal Stadium (22-18) | 41-45 | Won 4 |
| » Starters: Gene Conley vs Dan Pfister | Ninth | 8½ out |
| » Lost to Red Sox (41-44), 9-4 | Municipal Stadium (22-19) | 41-46 | |
| » Starters: Earl Wilson vs Ed Rakow | Ninth | 8½ out |
| Friday, July 13 |
| » Lost to Red Sox (42-44), 11-10 | Municipal Stadium (22-20) | 41-47 | Lost 2 |
| » Starters: Bill Monbouquette vs Jerry Walker | Ninth | 8½ out |
| Saturday, July 14 |
| » Lost to Red Sox (43-44), 4-2 | Municipal Stadium (22-21) | 41-48 | Lost 3 |
| » Starters: Arnold Earley vs Bill Fischer | Ninth | 9½ out |
| Sunday, July 15 |
| » Lost to Yankees (48-35), 8-6 | Municipal Stadium (22-22) | 41-49 | Lost 4 |
| » Starters: Bud Daley vs Diego Segui | Ninth | 11½ out |
| » Lost to Yankees (49-35), 11-3 | Municipal Stadium (22-23) | 41-50 | Lost 5 |
| » Starters: Rollie Sheldon vs Danny McDevitt | Ninth | 11½ out |
| Monday, July 16 |
| » Lost to Yankees (50-35), 3-1 | Municipal Stadium (22-24) | 41-51 | Lost 6 |
| » Starters: Whitey Ford vs Dan Pfister | Eighth | 12½ out |
| Tuesday, July 17 |
| » Lost to Orioles (47-44), 3-2 | Municipal Stadium (22-25) | 41-52 | Lost 7 |
| » Starters: Robin Roberts vs Ed Rakow | Ninth | 13½ out |
| Wednesday, July 18 |
| » Defeated Orioles (47-45), 3-2 | Municipal Stadium (23-25) | 42-52 | |
| » Starters: Milt Pappas vs Bob Giggie | Ninth | 13½ out |
| Thursday, July 19 |
| » Lost to Orioles (48-45), 7-3 | Municipal Stadium (23-26) | 42-53 | |
| » Starters: Steve Barber vs Bill Fischer | Ninth | 14½ out |
| Future Athletic Dick Scott is born in Ellsworth, ME. |
| Friday, July 20 |
| » Lost to Tigers (44-47), 10-3 | Municipal Stadium (23-27) | 42-54 | Lost 2 |
| » Starters: Don Mossi vs Diego Segui | Ninth | 15½ out |
| Saturday, July 21 |
| » Lost to Tigers (45-47), 7-5 | Municipal Stadium (23-28) | 42-55 | Lost 3 |
| » Starters: Hank Aguirre vs Dan Pfister | Ninth | 16½ out |
| Sunday, July 22 |
| » Defeated Tigers (45-48), 11-3 | Municipal Stadium (24-28) | 43-55 | |
| » Starters: Sam Jones vs Ed Rakow | Ninth | 15 out |
| Tuesday, July 24 |
| » Lost to Indians (50-45), 5-4 | Municipal Stadium (24-29) | 43-56 | |
| » Starters: Dick Donovan vs Bob Giggie | Eighth | 16 out |
| Wednesday, July 25 |
| » Defeated Indians (50-46), 5-4 | Municipal Stadium (25-29) | 44-56 | |
| » Starters: Sam McDowell vs Diego Segui | Eighth | 15½ out |
| Friday, July 27 |
| » Lost to Orioles (51-50), 3-2 | Memorial Stadium (0-3) | 44-57 | |
| » Starters: Dan Pfister vs Robin Roberts | Ninth | 17 out |
| Saturday, July 28 |
| » Lost to Orioles (52-50), 3-0 | Memorial Stadium (0-4) | 44-58 | Lost 2 |
| » Starters: Ed Rakow vs Steve Barber | Ninth | 18½ out |
| » Lost to Orioles (53-50), 7-1 | Memorial Stadium (0-5) | 44-59 | Lost 3 |
| » Starters: Jerry Walker vs Dick Hall | Ninth | 18½ out |
| Sunday, July 29 |
| » Defeated Orioles (53-51), 7-3 | Memorial Stadium (1-5) | 45-59 | |
| » Starters: Bill Fischer vs Chuck Estrada | Ninth | 18 out |
| Wednesday, August 1 |
| » Lost to Tigers (50-51), 6-5 | Tiger Stadium (1-3) | 45-60 | |
| » Starters: Dan Pfister vs Paul Foytack | Ninth | 20½ out |
| » Lost to Tigers (51-51), 9-1 | Tiger Stadium (1-4) | 45-61 | Lost 2 |
| » Starters: Jerry Walker vs Howie Koplitz | Ninth | 20½ out |
| Thursday, August 2 |
| » Defeated Tigers (51-52), 5-4 | Tiger Stadium (2-4) | 46-61 | |
| » Starters: Ed Rakow vs Hank Aguirre | Ninth | 20 out |
| Friday, August 3 |
| » Lost to Indians (53-52), 1-0 | Cleveland Stadium (1-2) | 46-62 | |
| » Starters: Bill Fischer vs Dick Donovan | Eighth | 21 out |
| Saturday, August 4 |
| » Defeated Indians (53-53), 8-3 | Cleveland Stadium (2-2) | 47-62 | |
| » Starters: Diego Segui vs Jim Perry | Ninth | 20 out |
| Sunday, August 5 |
| » Defeated Indians (53-54), 3-2 | Cleveland Stadium (3-2) | 48-62 | Won 2 |
| » Starters: Dan Pfister vs Barry Latman | Ninth | 18½ out |
| » Defeated Indians (53-55), 5-2 | Cleveland Stadium (4-2) | 49-62 | Won 3 |
| » Starters: Orlando Pena vs Pedro Ramos | Ninth | 18½ out |
| Monday, August 6 |
| » Defeated Senators (42-66), 1-0 | Robert F. Kennedy Stadium (6-2) | 50-62 | Won 4 |
| » Starters: Ed Rakow vs Claude Osteen | Ninth | 17½ out |
| Tuesday, August 7 |
| » Defeated Senators (42-67), 10-3 | Robert F. Kennedy Stadium (7-2) | 51-62 | Won 5 |
| » Starters: Bill Fischer vs Don Rudolph | Eighth | 17½ out |
| Wednesday, August 8 |
| » Defeated Twins (63-50), 4-3 | Municipal Stadium (26-29) | 52-62 | Won 6 |
| » Starters: Jack Kralick vs Diego Segui | Eighth | 17 out |
| Thursday, August 9 |
| » Lost to Twins (64-50), 12-10 | Municipal Stadium (26-30) | 52-63 | |
| » Starters: Lee Stange vs Dan Pfister | Seventh | 17½ out |
| Friday, August 10 |
| » Lost to White Sox (58-58), 3-1 | Municipal Stadium (26-31) | 52-64 | Lost 2 |
| » Starters: Early Wynn vs Orlando Pena | Ninth | 18½ out |
| Saturday, August 11 |
| » Lost to White Sox (59-58), 11-2 | Municipal Stadium (26-32) | 52-65 | Lost 3 |
| » Starters: John Buzhardt vs Ed Rakow | Ninth | 19 out |
| Sunday, August 12 |
| » Lost to White Sox (60-58), 1-0 | Municipal Stadium (26-33) | 52-66 | Lost 4 |
| » Starters: Ray Herbert vs Bill Fischer | Ninth | 20 out |
| Tuesday, August 14 |
| » Defeated Senators (45-73), 6-5 | Municipal Stadium (27-33) | 53-66 | |
| » Starters: Tom Cheney vs Orlando Pena | Ninth | 19½ out |
| Wednesday, August 15 |
| » Defeated Senators (45-74), 8-4 | Municipal Stadium (28-33) | 54-66 | Won 2 |
| » Starters: Dave Stenhouse vs Dan Pfister | Eighth | 19½ out |
| Thursday, August 16 |
| » Defeated Senators (45-75), 4-2 | Municipal Stadium (29-33) | 55-66 | Won 3 |
| » Starters: Claude Osteen vs Ed Rakow | Ninth | 18½ out |
| Friday, August 17 |
| » Defeated Yankees (72-47), 7-2 | Municipal Stadium (30-33) | 56-66 | Won 4 |
| » Starters: Jim Bouton vs Bill Fischer | Ninth | 17½ out |
| Saturday, August 18 |
| » Defeated Yankees (72-48), 5-4 | Municipal Stadium (31-33) | 57-66 | Won 5 |
| » Starters: Whitey Ford vs Diego Segui | Ninth | 17½ out |
| » Lost to Yankees (73-48), 11-7 | Municipal Stadium (31-34) | 57-67 | |
| » Starters: Bob Turley vs Orlando Pena | Ninth | 17½ out |
| Sunday, August 19 |
| » Lost to Yankees (74-48), 21-7 | Municipal Stadium (31-35) | 57-68 | Lost 2 |
| » Starters: Ralph Terry vs Dan Pfister | Ninth | 18½ out |
| Monday, August 20 |
| » Defeated Yankees (74-49), 7-3 | Municipal Stadium (32-35) | 58-68 | |
| » Starters: Rollie Sheldon vs Ed Rakow | Ninth | 17½ out |
| Tuesday, August 21 |
| » Lost to Red Sox (59-67), 11-6 | Municipal Stadium (32-36) | 58-69 | |
| » Starters: Earl Wilson vs Bill Fischer | Ninth | 18½ out |
| Wednesday, August 22 |
| » Defeated Red Sox (59-68), 4-2 | Municipal Stadium (33-36) | 59-69 | |
| » Starters: Ike Delock vs Moe Drabowsky | Ninth | 18½ out |
| Thursday, August 23 |
| » Lost to Red Sox (60-68), 8-2 | Municipal Stadium (33-37) | 59-70 | |
| » Starters: Gene Conley vs Diego Segui | Ninth | 18½ out |
| Friday, August 24 |
| » Defeated Twins (72-59), 12-1 | Metropolitan Stadium (3-4) | 60-70 | |
| » Starters: Orlando Pena vs Bill Pleis | Ninth | 17 out |
| Saturday, August 25 |
| » Lost to Twins (73-59), 3-1 | Metropolitan Stadium (3-5) | 60-71 | |
| » Starters: Ed Rakow vs Dick Stigman | Ninth | 16½ out |
| Sunday, August 26 |
| » Lost to Twins (74-59), 1-0 | Metropolitan Stadium (3-6) | 60-72 | Lost 2 |
| » Starters: Bill Fischer vs Jack Kralick | Eighth | 16½ out |
| Tuesday, August 28 |
| » Lost to Angels (74-58), 10-5 | Municipal Stadium (33-38) | 60-73 | Lost 3 |
| » Starters: Dean Chance vs Moe Drabowsky | Ninth | 18 out |
| Wednesday, August 29 |
| » Defeated Angels (74-59), 6-0 | Municipal Stadium (34-38) | 61-73 | |
| » Starters: Bo Belinsky vs Orlando Pena | Ninth | 16½ out |
| Friday, August 31 |
| » Lost to Yankees (79-57), 5-1 | Yankee Stadium (1-6) | 61-74 | |
| » Starters: Ed Rakow vs Whitey Ford | Ninth | 17½ out |
| Saturday, September 1 |
| » Lost to Yankees (80-57), 3-1 | Yankee Stadium (1-7) | 61-75 | Lost 2 |
| » Starters: Bill Fischer vs Ralph Terry | Ninth | 18½ out |
| Sunday, September 2 |
| » Lost to Yankees (81-57), 2-1 | Yankee Stadium (1-8) | 61-76 | Lost 3 |
| » Starters: Orlando Pena vs Jim Bouton | Ninth | 19½ out |
| Monday, September 3 |
| » Defeated Red Sox (64-73), 8-5 | Fenway Park (4-2) | 62-76 | |
| » Starters: Moe Drabowsky vs Ike Delock | Ninth | 19½ out |
| » Lost to Red Sox (65-73), 3-1 | Fenway Park (4-3) | 62-77 | |
| » Starters: Dan Pfister vs Don Schwall | Ninth | 19½ out |
| Tuesday, September 4 |
| » Defeated Red Sox (65-74), 7-2 | Fenway Park (5-3) | 63-77 | |
| » Starters: Ed Rakow vs Bill Monbouquette | Ninth | 18½ out |
| Wednesday, September 5 |
| » Lost to Red Sox (66-74), 12-4 | Fenway Park (5-4) | 63-78 | |
| » Starters: Bill Fischer vs Earl Wilson | Ninth | 19 out |
| Friday, September 7 |
| » Lost to Indians (69-75), 2-1 | Cleveland Stadium (4-3) | 63-79 | Lost 2 |
| » Starters: Orlando Pena vs Pedro Ramos | Ninth | 20½ out |
| Saturday, September 8 |
| » Lost to Indians (70-75), 3-2 | Cleveland Stadium (4-4) | 63-80 | Lost 3 |
| » Starters: Dan Pfister vs Barry Latman | Ninth | 21½ out |
| Sunday, September 9 |
| » Lost to Indians (71-75), 12-7 | Cleveland Stadium (4-5) | 63-81 | Lost 4 |
| » Starters: Ed Rakow vs Dick Donovan | Ninth | 21 out |
| Monday, September 10 |
| » Lost to White Sox (76-70), 4-3 | Comiskey Park I (5-4) | 63-82 | Lost 5 |
| » Starters: Bill Fischer vs Ray Herbert | Ninth | 22 out |
| Wednesday, September 12 |
| » Defeated Angels (82-65), 4-1 | Dodger Stadium (2-6) | 64-82 | |
| » Starters: Orlando Pena vs Bo Belinsky | Ninth | 22½ out |
| Thursday, September 13 |
| » Defeated Angels (82-66), 5-4 | Dodger Stadium (3-6) | 65-82 | Won 2 |
| » Starters: Dan Pfister vs Ted Bowsfield | Ninth | 22 out |
| » Major-league debuts: Ed Kirkpatrick (Angels) |
| Saturday, September 15 |
| » Defeated Orioles (73-76), 4-3 | Municipal Stadium (35-38) | 66-82 | Won 3 |
| » Starters: Jack Fisher vs Ed Rakow | Ninth | 21 out |
| » Defeated Orioles (73-77), 5-4 | Municipal Stadium (36-38) | 67-82 | Won 4 |
| » Starters: Robin Roberts vs Bill Fischer | Ninth | 21 out |
| Sunday, September 16 |
| » Defeated Orioles (73-78), 12-5 | Municipal Stadium (37-38) | 68-82 | Won 5 |
| » Starters: Milt Pappas vs Orlando Pena | Eighth | 20 out |
| Monday, September 17 |
| » Major-league debuts: Ken McMullen (Dodgers) |
| Tuesday, September 18 |
| » Defeated Indians (72-80), 6-1 | Municipal Stadium (38-38) | 69-82 | Won 6 |
| » Starters: Jim Perry vs Dan Pfister | Ninth | 20 out |
| Wednesday, September 19 |
| » Lost to Indians (73-80), 10-9 | Municipal Stadium (38-39) | 69-83 | |
| » Starters: Dick Donovan vs Ed Rakow | Eighth | 21 out |
| Thursday, September 20 |
| » Lost to Indians (74-80), 5-2 | Municipal Stadium (38-40) | 69-84 | Lost 2 |
| » Starters: Pedro Ramos vs Bill Fischer | Ninth | 21½ out |
| Friday, September 21 |
| » Lost to Tigers (80-74), 6-1 | Municipal Stadium (38-41) | 69-85 | Lost 3 |
| » Starters: Don Mossi vs Orlando Pena | Ninth | 21½ out |
| Saturday, September 22 |
| » Defeated Tigers (80-75), 5-2 | Municipal Stadium (39-41) | 70-85 | |
| » Starters: Jim Bunning vs Dave Wickersham | Ninth | 20½ out |
| Sunday, September 23 |
| » Lost to Tigers (81-75), 3-1 | Municipal Stadium (39-42) | 70-86 | |
| » Starters: Hank Aguirre vs Dan Pfister | Ninth | 21½ out |
| Monday, September 24 |
| » Defeated Orioles (76-81), 5-2 | Memorial Stadium (2-5) | 71-86 | |
| » Starters: Ed Rakow vs Jack Fisher | Eighth | 21 out |
| Wednesday, September 26 |
| » Lost to Orioles (77-81), 3-0 | Memorial Stadium (2-6) | 71-87 | |
| » Starters: Bill Fischer vs Dave McNally | Ninth | 22 out |
| » Defeated Orioles (77-82), 6-2 | Memorial Stadium (3-6) | 72-87 | |
| » Starters: Orlando Pena vs Robin Roberts | Ninth | 22 out |
| » Major-league debuts: Andy Etchebarren and Dave McNally (Orioles) |
| Thursday, September 27 |
| Former Athletic Stan Sperry dies in Evansville, WI at the age of 49. |
| Friday, September 28 |
| » Lost to Tigers |
