| Wednesday, January 10 |
| Future Astro Jim Lindeman is born in Evanston, IL. |
| Tuesday, January 23 |
| Future Astro Benny Distefano is born in Brooklyn, NY. |
| Friday, February 16 |
| Future Astro Dwayne Henry is born in Elkton, MD. |
| Sunday, February 18 |
| Future Astro Rocky Childress is born in Santa Rosa, CA. |
| Sunday, March 18 |
| Future Astro Brian Fisher is born in Honolulu, HI. |
| Tuesday, April 10 |
| » Defeated Cubs (0-1), 11-2 | Colt Stadium (1-0) | 1-0 | |
| » Starters: Don Cardwell vs Bobby Shantz | First | -- |
| Wednesday, April 11 |
| » Defeated Cubs (0-2), 2-0 | Colt Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Glen Hobbie vs Hal Woodeshick | First | -- |
| Thursday, April 12 |
| » Defeated Cubs (0-3), 2-0 | Colt Stadium (3-0) | 3-0 | Won 3 |
| » Starters: Jack Curtis vs Dean Stone | First | -- |
| Friday, April 13 |
| » Lost to Phillies (2-1), 3-2 | Shibe Park (0-1) | 3-1 | |
| » Starters: Turk Farrell vs Jack Hamilton | Third | 1 out |
| » Major-league debuts: Jack Hamilton (Phillies) Dave Giusti and Merritt Ranew (Astros) |
| Saturday, April 14 |
| » Lost to Phillies (3-1), 3-0 | Shibe Park (0-2) | 3-2 | Lost 2 |
| » Starters: Ken Johnson vs Art Mahaffey | Fifth | 2 out |
| Sunday, April 15 |
| » Major-league debuts: Dick Phillips (Giants) |
| Tuesday, April 17 |
| » Defeated Mets (0-5), 5-2 | Polo Grounds V (1-0) | 4-2 | |
| » Starters: Bobby Shantz vs Jay Hook | Fourth | 2 out |
| Wednesday, April 18 |
| » Lost to Cubs (1-7), 3-2 | Wrigley Field (0-1) | 4-3 | |
| » Starters: Hal Woodeshick vs Dick Ellsworth | Fourth | 3 out |
| Thursday, April 19 |
| » Defeated Cubs (1-8), 6-0 | Wrigley Field (1-1) | 5-3 | |
| » Starters: Dean Stone vs Don Cardwell | Fourth | 3 out |
| Saturday, April 21 |
| » Lost to Phillies (4-4), 3-1 | Colt Stadium (3-1) | 5-4 | |
| » Starters: Cal McLish vs Ken Johnson | Fifth | 4 out |
| Sunday, April 22 |
| » Lost to Phillies (5-4), 4-3 | Colt Stadium (3-2) | 5-5 | Lost 2 |
| » Starters: Jim Owens vs Dave Giusti | Sixth | 5 out |
| Tuesday, April 24 |
| » Defeated Cardinals (7-3), 4-3 | Colt Stadium (4-2) | 6-5 | |
| » Starters: Larry Jackson vs Hal Woodeshick | Fourth | 4½ out |
| Wednesday, April 25 |
| » Tied Cardinals, 5-5 | Colt Stadium (4-2) | 6-5 | |
| » Starters: Ray Washburn vs Dean Stone | Fifth | 4 out |
| Thursday, April 26 |
| » Lost to Cardinals (8-3), 3-2 | Colt Stadium (4-3) | 6-6 | |
| » Starters: Bob Gibson vs Ken Johnson | Fifth | 4½ out |
| Friday, April 27 |
| » Lost to Braves (7-9), 2-1 | Colt Stadium (4-4) | 6-7 | Lost 2 |
| » Starters: Bob Shaw vs Bobby Shantz | Fifth | 4½ out |
| Saturday, April 28 |
| » Lost to Braves (8-9), 9-3 | Colt Stadium (4-5) | 6-8 | Lost 3 |
| » Starters: Carl Willey vs Dave Giusti | Sixth | 4½ out |
| Sunday, April 29 |
| » Defeated Braves (8-10), 3-2 | Colt Stadium (5-5) | 7-8 | |
| » Starters: Lew Burdette vs Hal Woodeshick | Fifth | 5 out |
| Tuesday, May 1 |
| » Lost to Cardinals (12-4), 6-4 | Sportsman's Park III (0-1) | 7-9 | |
| » Starters: Dean Stone vs Ray Washburn | Seventh | 6½ out |
| Wednesday, May 2 |
| » Lost to Cardinals (13-4), 4-1 | Sportsman's Park III (0-2) | 7-10 | Lost 2 |
| » Starters: Ken Johnson vs Bob Gibson | Eighth | 7½ out |
| Thursday, May 3 |
| » Lost to Cardinals (14-4), 4-0 | Sportsman's Park III (0-3) | 7-11 | Lost 3 |
| » Starters: Dave Giusti vs Curt Simmons | Eighth | 8½ out |
| Friday, May 4 |
| » Defeated Braves (8-13), 7-4 | County Stadium (1-0) | 8-11 | |
| » Starters: Hal Woodeshick vs Bob Hendley | Seventh | 8½ out |
| Saturday, May 5 |
| » Lost to Braves (9-13), 6-5 | County Stadium (1-1) | 8-12 | |
| » Starters: Dean Stone vs Bob Shaw | Eighth | 8½ out |
| Sunday, May 6 |
| » Lost to Braves (10-13), 3-2 | County Stadium (1-2) | 8-13 | Lost 2 |
| » Starters: Jim Golden vs Warren Spahn | Eighth | 9 out |
| » Defeated Braves (10-14), 9-1 | County Stadium (2-2) | 9-13 | |
| » Starters: Turk Farrell vs Carl Willey | Eighth | 9 out |
| Monday, May 7 |
| » Defeated Dodgers (15-11), 9-6 | Colt Stadium (6-5) | 10-13 | Won 2 |
| » Starters: Joe Moeller vs Dave Giusti | Seventh | 8½ out |
| Tuesday, May 8 |
| » Lost to Dodgers (16-11), 9-6 | Colt Stadium (6-6) | 10-14 | |
| » Starters: Sandy Koufax vs Ken Johnson | Seventh | 9½ out |
| Wednesday, May 9 |
| » Lost to Dodgers (17-11), 9-2 | Colt Stadium (6-7) | 10-15 | Lost 2 |
| » Starters: Johnny Podres vs Dean Stone | Eighth | 9½ out |
| Thursday, May 10 |
| » Lost to Dodgers (18-11), 6-2 | Colt Stadium (6-8) | 10-16 | Lost 3 |
| » Starters: Don Drysdale vs Bob Bruce | Eighth | 10½ out |
| Friday, May 11 |
| » Defeated Giants (22-8), 7-0 | Colt Stadium (7-8) | 11-16 | |
| » Starters: Gaylord Perry vs Turk Farrell | Eighth | 9½ out |
| Saturday, May 12 |
| » Lost to Giants (23-8), 11-0 | Colt Stadium (7-9) | 11-17 | |
| » Starters: Juan Marichal vs Hal Woodeshick | Eighth | 10½ out |
| Sunday, May 13 |
| » Lost to Giants (24-8), 7-2 | Colt Stadium (7-10) | 11-18 | Lost 2 |
| » Starters: Jack Sanford vs Ken Johnson | Eighth | 11½ out |
| Tuesday, May 15 |
| » Lost to Dodgers (21-12), 10-7 | Dodger Stadium (0-1) | 11-19 | Lost 3 |
| » Starters: Bob Bruce vs Don Drysdale | Eighth | 12½ out |
| Wednesday, May 16 |
| » Lost to Dodgers (22-12), 5-2 | Dodger Stadium (0-2) | 11-20 | Lost 4 |
| » Starters: Turk Farrell vs Joe Moeller | Eighth | 13½ out |
| Thursday, May 17 |
| » Lost to Dodgers (23-12), 5-4 | Dodger Stadium (0-3) | 11-21 | Lost 5 |
| » Starters: Jim Golden vs Sandy Koufax | Eighth | 13½ out |
| Friday, May 18 |
| » Defeated Giants (26-10), 3-2 | Candlestick Park (1-0) | 12-21 | |
| » Starters: Ken Johnson vs Jack Sanford | Eighth | 12½ out |
| Saturday, May 19 |
| » Lost to Giants (27-10), 10-2 | Candlestick Park (1-1) | 12-22 | |
| » Starters: George Witt vs Mike McCormick | Eighth | 13½ out |
| Sunday, May 20 |
| » Defeated Giants (27-11), 6-5 | Candlestick Park (2-1) | 13-22 | |
| » Starters: Bob Bruce vs Juan Marichal | Ninth | 13½ out |
| » Lost to Giants (28-11), 7-4 | Candlestick Park (2-2) | 13-23 | |
| » Starters: Hal Woodeshick vs Billy Pierce | Ninth | 13½ out |
| Monday, May 21 |
| » Defeated Mets (12-20), 3-2 | Colt Stadium (8-10) | 14-23 | |
| » Starters: Dave Hillman vs Jim Golden | Eighth | 12½ out |
| Tuesday, May 22 |
| » Defeated Mets (12-21), 3-2 | Colt Stadium (9-10) | 15-23 | Won 2 |
| » Starters: Jay Hook vs Turk Farrell | Eighth | 11½ out |
| Wednesday, May 23 |
| » Defeated Reds (20-16), 2-0 | Colt Stadium (10-10) | 16-23 | Won 3 |
| » Starters: Bob Purkey vs Ken Johnson | Eighth | 10½ out |
| Thursday, May 24 |
| » Lost to Reds (21-16), 5-0 | Colt Stadium (10-11) | 16-24 | |
| » Starters: Joey Jay vs George Witt | Eighth | 11½ out |
| Friday, May 25 |
| » Lost to Pirates (21-17), 4-3 | Colt Stadium (10-12) | 16-25 | Lost 2 |
| » Starters: Earl Francis vs Bob Bruce | Eighth | 12½ out |
| Saturday, May 26 |
| » Defeated Pirates (21-18), 2-0 | Colt Stadium (11-12) | 17-25 | |
| » Starters: Bob Friend vs Jim Golden | Seventh | 12½ out |
| Sunday, May 27 |
| » Lost to Pirates (22-18), 7-2 | Colt Stadium (11-13) | 17-26 | |
| » Starters: Vern Law vs Ken Johnson | Seventh | 14 out |
| Monday, May 28 |
| » Lost to Reds (25-16), 9-6 | Crosley Field (0-1) | 17-27 | Lost 2 |
| » Starters: Turk Farrell vs Joey Jay | Seventh | 14½ out |
| Wednesday, May 30 |
| » Defeated Cubs (15-31), 8-6 | Wrigley Field (2-1) | 18-27 | |
| » Starters: Dean Stone vs Cal Koonce | Seventh | 15 out |
| Thursday, May 31 |
| » Defeated Cubs (15-32), 10-6 | Wrigley Field (3-1) | 19-27 | Won 2 |
| » Starters: Bob Bruce vs Dick Ellsworth | Seventh | 14 out |
| Friday, June 1 |
| » Lost to Pirates (27-18), 8-4 | Forbes Field (0-1) | 19-28 | |
| » Starters: Jim Golden vs Joe Gibbon | Sixth | 15 out |
| Saturday, June 2 |
| » Lost to Pirates (28-18), 9-2 | Forbes Field (0-2) | 19-29 | Lost 2 |
| » Starters: Turk Farrell vs Vern Law | Seventh | 16½ out |
| Sunday, June 3 |
| » Defeated Pirates (28-19), 10-6 | Forbes Field (1-2) | 20-29 | |
| » Starters: Dave Giusti vs Harvey Haddix | Seventh | 16 out |
| » Defeated Pirates (28-20), 10-3 | Forbes Field (2-2) | 21-29 | Won 2 |
| » Starters: Ken Johnson vs Al McBean | Seventh | 16 out |
| Tuesday, June 5 |
| » Defeated Braves (24-28), 7-1 | Colt Stadium (12-13) | 22-29 | Won 3 |
| » Starters: Ron Piche vs Bob Bruce | Seventh | 16 out |
| Wednesday, June 6 |
| » Lost to Braves (25-28), 6-3 | Colt Stadium (12-14) | 22-30 | |
| » Starters: Lew Burdette vs Jim Golden | Seventh | 16 out |
| Thursday, June 7 |
| » Defeated Braves (25-29), 3-2 | Colt Stadium (13-14) | 23-30 | |
| » Starters: Warren Spahn vs Turk Farrell | Seventh | 15 out |
| Friday, June 8 |
| » Lost to Dodgers (41-18), 4-3 | Colt Stadium (13-15) | 23-31 | |
| » Starters: Sandy Koufax vs Ken Johnson | Seventh | 15½ out |
| Saturday, June 9 |
| » Defeated Dodgers (41-19), 13-1 | Colt Stadium (14-15) | 24-31 | |
| » Starters: Stan Williams vs Bob Bruce | Seventh | 14½ out |
| Sunday, June 10 |
| » Lost to Dodgers (42-19), 9-3 | Colt Stadium (14-16) | 24-32 | |
| » Starters: Don Drysdale vs Jim Golden | Seventh | 16½ out |
| » Lost to Dodgers (43-19), 9-7 | Colt Stadium (14-17) | 24-33 | Lost 2 |
| » Starters: Joe Moeller vs Hal Woodeshick | Seventh | 16½ out |
| Monday, June 11 |
| » Lost to Mets (16-38), 3-1 | Colt Stadium (14-18) | 24-34 | Lost 3 |
| » Starters: Al Jackson vs Turk Farrell | Eighth | 17 out |
| Tuesday, June 12 |
| » Defeated Mets (16-39), 3-2 | Colt Stadium (15-18) | 25-34 | |
| » Starters: Bob Miller vs Ken Johnson | Seventh | 16 out |
| Thursday, June 14 |
| » Defeated Mets (16-40), 10-2 | Colt Stadium (16-18) | 26-34 | Won 2 |
| » Starters: Jay Hook vs Bob Bruce | Sixth | 15½ out |
| Friday, June 15 |
| » Defeated Dodgers (44-22), 2-0 | Dodger Stadium (1-3) | 27-34 | Won 3 |
| » Starters: Jim Golden vs Don Drysdale | Seventh | 14½ out |
| Saturday, June 16 |
| » Defeated Dodgers (44-23), 4-1 | Dodger Stadium (2-3) | 28-34 | Won 4 |
| » Starters: Turk Farrell vs Johnny Podres | Seventh | 13½ out |
| Sunday, June 17 |
| » Lost to Dodgers (45-23), 6-2 | Dodger Stadium (2-4) | 28-35 | |
| » Starters: Ken Johnson vs Joe Moeller | Seventh | 14½ out |
| Tuesday, June 19 |
| » Defeated Giants (44-25), 6-4 | Candlestick Park (3-2) | 29-35 | |
| » Starters: Hal Woodeshick vs Billy O'Dell | Seventh | 15 out |
| Wednesday, June 20 |
| » Defeated Giants (44-26), 9-5 | Candlestick Park (4-2) | 30-35 | Won 2 |
| » Starters: Bob Bruce vs Juan Marichal | Seventh | 14 out |
| Friday, June 22 |
| » Lost to Mets (18-47), 2-0 | Polo Grounds V (1-1) | 30-36 | |
| » Starters: Turk Farrell vs Al Jackson | Seventh | 13½ out |
| » Defeated Mets (18-48), 16-3 | Polo Grounds V (2-1) | 31-36 | |
| » Starters: Jim Golden vs Bob Miller | Seventh | 13½ out |
| Saturday, June 23 |
| » Lost to Mets (19-48), 13-2 | Polo Grounds V (2-2) | 31-37 | |
| » Starters: Ken Johnson vs Jay Hook | Sixth | 14½ out |
| Monday, June 25 |
| » Lost to Phillies (31-39), 4-3 | Shibe Park (0-3) | 31-38 | Lost 2 |
| » Starters: Hal Woodeshick vs Cal McLish | Seventh | 14 out |
| Tuesday, June 26 |
| » Lost to Phillies (32-39), 2-0 | Shibe Park (0-4) | 31-39 | Lost 3 |
| » Starters: Turk Farrell vs Jack Hamilton | Eighth | 15 out |
| » Lost to Phillies (33-39), 6-4 | Shibe Park (0-5) | 31-40 | Lost 4 |
| » Starters: Jim Golden vs Art Mahaffey | Eighth | 15 out |
| Friday, June 29 |
| » Lost to Reds (39-33), 4-0 | Colt Stadium (16-19) | 31-41 | Lost 5 |
| » Starters: Jim O'Toole vs Ken Johnson | Seventh | 16 out |
| Saturday, June 30 |
| » Defeated Reds (39-34), 7-3 | Colt Stadium (17-19) | 32-41 | |
| » Starters: Jim Maloney vs Bob Bruce | Eighth | 16 out |
| Sunday, July 1 |
| » Lost to Reds (40-34), 6-1 | Colt Stadium (17-20) | 32-42 | |
| » Starters: Joey Jay vs Jim Golden | Eighth | 17 out |
| Monday, July 2 |
| » Lost to Pirates (46-32), 4-2 | Colt Stadium (17-21) | 32-43 | Lost 2 |
| » Starters: Bob Friend vs Hal Woodeshick | Eighth | 18 out |
| Tuesday, July 3 |
| » Lost to Pirates (47-32), 5-2 | Colt Stadium (17-22) | 32-44 | Lost 3 |
| » Starters: Harvey Haddix vs Ken Johnson | Eighth | 18½ out |
| » Major-league debuts: Ernie Fazio (Astros) |
| Wednesday, July 4 |
| » Lost to Pirates (48-32), 7-0 | Colt Stadium (17-23) | 32-45 | Lost 4 |
| » Starters: Vern Law vs Bob Bruce | Eighth | 20½ out |
| » Lost to Pirates (49-32), 4-3 | Colt Stadium (17-24) | 32-46 | Lost 5 |
| » Starters: Earl Francis vs Jim Golden | Eighth | 20½ out |
| Friday, July 6 |
| » Defeated Reds (43-36), 2-0 | Crosley Field (1-1) | 33-46 | |
| » Starters: Hal Woodeshick vs Joey Jay | Eighth | 20 out |
| Saturday, July 7 |
| » Lost to Reds (44-36), 10-1 | Crosley Field (1-2) | 33-47 | |
| » Starters: Ken Johnson vs Bob Purkey | Eighth | 20½ out |
| Sunday, July 8 |
| » Lost to Reds (45-36), 12-8 | Crosley Field (1-3) | 33-48 | Lost 2 |
| » Starters: Bob Bruce vs Jim O'Toole | Eighth | 21½ out |
| » Lost to Reds (46-36), 12-11 | Crosley Field (1-4) | 33-49 | Lost 3 |
| » Starters: Jim Golden vs Ted Wills | Eighth | 21½ out |
| Wednesday, July 11 |
| » Lost to Phillies (37-49), 6-1 | Shibe Park (0-6) | 33-50 | Lost 4 |
| » Starters: Hal Woodeshick vs Art Mahaffey | Eighth | 22 out |
| Thursday, July 12 |
| » Lost to Pirates (53-34), 6-4 | Forbes Field (2-3) | 33-51 | Lost 5 |
| » Starters: Jim Golden vs Al McBean | Eighth | 23 out |
| Friday, July 13 |
| » Lost to Pirates (54-34), 4-0 | Forbes Field (2-4) | 33-52 | Lost 6 |
| » Starters: Turk Farrell vs Bob Friend | Eighth | 24 out |
| Saturday, July 14 |
| » Lost to Pirates (55-34), 4-2 | Forbes Field (2-5) | 33-53 | Lost 7 |
| » Starters: Bob Bruce vs Vern Law | Eighth | 25 out |
| Sunday, July 15 |
| » Defeated Cubs (34-58), 5-4 | Colt Stadium (18-24) | 34-53 | |
| » Starters: Bob Buhl vs Hal Woodeshick | Eighth | 25 out |
| » Lost to Cubs (35-58), 4-1 | Colt Stadium (18-25) | 34-54 | |
| » Starters: Dick Ellsworth vs Ken Johnson | Eighth | 25 out |
| Tuesday, July 17 |
| » Lost to Phillies (41-51), 3-0 | Colt Stadium (18-26) | 34-55 | Lost 2 |
| » Starters: Jack Hamilton vs Russ Kemmerer | Eighth | 25½ out |
| » Lost to Phillies (42-51), 8-2 | Colt Stadium (18-27) | 34-56 | Lost 3 |
| » Starters: Cal McLish vs Turk Farrell | Eighth | 25½ out |
| » Major-league debuts: Jim Campbell (Astros) |
| Wednesday, July 18 |
| » Lost to Phillies (43-51), 6-2 | Colt Stadium (18-28) | 34-57 | Lost 4 |
| » Starters: Dallas Green vs Bob Bruce | Eighth | 26½ out |
| Thursday, July 19 |
| » Lost to Phillies (44-51), 6-2 | Colt Stadium (18-29) | 34-58 | Lost 5 |
| » Starters: Paul Brown vs Hal Woodeshick | Eighth | 26½ out |
| Friday, July 20 |
| » Defeated Cardinals (53-42), 4-3 | Colt Stadium (19-29) | 35-58 | |
| » Starters: Ray Washburn vs Turk Farrell | Eighth | 26½ out |
| Saturday, July 21 |
| » Lost to Cardinals (54-42), 7-0 | Colt Stadium (19-30) | 35-59 | |
| » Starters: Larry Jackson vs Russ Kemmerer | Eighth | 27 out |
| » Defeated Cardinals (54-43), 7-3 | Colt Stadium (20-30) | 36-59 | |
| » Starters: Curt Simmons vs Ken Johnson | Eighth | 27 out |
| Sunday, July 22 |
| » Lost to Cardinals (55-43), 3-1 | Colt Stadium (20-31) | 36-60 | |
| » Starters: Bob Gibson vs Bob Bruce | Eighth | 28 out |
| Monday, July 23 |
| » Lost to Giants (65-36), 5-1 | Colt Stadium (20-32) | 36-61 | Lost 2 |
| » Starters: Bobby Bolin vs Hal Woodeshick | Eighth | 29 out |
| Tuesday, July 24 |
| » Lost to Giants (66-36), 3-1 | Colt Stadium (20-33) | 36-62 | Lost 3 |
| » Starters: Jack Sanford vs Turk Farrell | Eighth | 29 out |
| Wednesday, July 25 |
| » Lost to Giants (67-36), 3-2 | Colt Stadium (20-34) | 36-63 | Lost 4 |
| » Starters: Billy O'Dell vs Jim Golden | Eighth | 30 out |
| Future Astro Doug Drabek is born in Victoria, TX. |
| Friday, July 27 |
| » Lost to Cubs (38-65), 5-1 | Wrigley Field (3-2) | 36-64 | Lost 5 |
| » Starters: Hal Woodeshick vs Dick Ellsworth | Ninth | 31 out |
| Sunday, July 29 |
| » Lost to Cubs (39-65), 4-2 | Wrigley Field (3-3) | 36-65 | Lost 6 |
| » Starters: Bob Bruce vs Cal Koonce | Ninth | 32 out |
| » Defeated Cubs (39-66), 3-1 | Wrigley Field (4-3) | 37-65 | |
| » Starters: Ken Johnson vs Glen Hobbie | Ninth | 32 out |
| Wednesday, August 1 |
| » Lost to Braves (55-52), 3-0 | County Stadium (2-3) | 37-66 | |
| » Starters: Hal Woodeshick vs Bob Shaw | Ninth | 32 out |
| » Major-league debuts: Ron Davis (Astros) |
| Thursday, August 2 |
| » Defeated Braves (55-53), 3-0 | County Stadium (3-3) | 38-66 | |
| » Starters: Turk Farrell vs Lew Burdette | Ninth | 32 out |
| Friday, August 3 |
| » Defeated Cardinals (60-49), 8-3 | Sportsman's Park III (1-3) | 39-66 | Won 2 |
| » Starters: Ken Johnson vs Bob Gibson | Eighth | 32 out |
| Saturday, August 4 |
| » Lost to Cardinals (61-49), 2-0 | Sportsman's Park III (1-4) | 39-67 | |
| » Starters: Bob Bruce vs Ray Washburn | Eighth | 33 out |
| Sunday, August 5 |
| » Defeated Cardinals (61-50), 7-4 | Sportsman's Park III (2-4) | 40-67 | |
| » Starters: George Brunet vs Larry Jackson | Eighth | 33 out |
| » Lost to Cardinals (62-50), 7-4 | Sportsman's Park III (2-5) | 40-68 | |
| » Starters: Hal Woodeshick vs Paul Toth | Eighth | 33 out |
| Monday, August 6 |
| » Lost to Reds (65-46), 1-0 | Colt Stadium (20-35) | 40-69 | Lost 2 |
| » Starters: Bob Purkey vs Turk Farrell | Eighth | 34 out |
| Tuesday, August 7 |
| » Lost to Reds (66-46), 3-0 | Colt Stadium (20-36) | 40-70 | Lost 3 |
| » Starters: Joey Jay vs Ken Johnson | Eighth | 35 out |
| Wednesday, August 8 |
| » Lost to Reds (67-46), 4-0 | Colt Stadium (20-37) | 40-71 | Lost 4 |
| » Starters: Joe Nuxhall vs Bob Bruce | Ninth | 36 out |
| Thursday, August 9 |
| » Lost to Reds (68-46), 7-3 | Colt Stadium (20-38) | 40-72 | Lost 5 |
| » Starters: Jim O'Toole vs Hal Woodeshick | Ninth | 37 out |
| Friday, August 10 |
| » Lost to Braves (62-54), 7-6 | Colt Stadium (20-39) | 40-73 | Lost 6 |
| » Starters: Warren Spahn vs George Brunet | Ninth | 37 out |
| Saturday, August 11 |
| » Lost to Braves (63-54), 3-1 | Colt Stadium (20-40) | 40-74 | Lost 7 |
| » Starters: Bob Shaw vs Turk Farrell | Ninth | 37 out |
| Sunday, August 12 |
| » Defeated Braves (63-55), 8-5 | Colt Stadium (21-40) | 41-74 | |
| » Starters: Lew Burdette vs Bob Bruce | Ninth | 36 out |
| Tuesday, August 14 |
| » Defeated Cardinals (65-54), 4-3 | Colt Stadium (22-40) | 42-74 | Won 2 |
| » Starters: Bob Gibson vs Ken Johnson | Eighth | 35 out |
| Wednesday, August 15 |
| » Defeated Cardinals (65-55), 3-1 | Colt Stadium (23-40) | 43-74 | Won 3 |
| » Starters: Ray Washburn vs Hal Woodeshick | Eighth | 34 out |
| Thursday, August 16 |
| » Lost to Cardinals (66-55), 3-1 | Colt Stadium (23-41) | 43-75 | |
| » Starters: Larry Jackson vs Turk Farrell | Ninth | 35 out |
| Friday, August 17 |
| » Defeated Cubs (45-77), 3-2 | Colt Stadium (24-41) | 44-75 | |
| » Starters: Dick Ellsworth vs Bob Bruce | Eighth | 35 out |
| Saturday, August 18 |
| » Defeated Cubs (45-78), 2-1 | Colt Stadium (25-41) | 45-75 | Won 2 |
| » Starters: Cal Koonce vs George Brunet | Eighth | 34½ out |
| » Lost to Cubs (46-78), 6-5 | Colt Stadium (25-42) | 45-76 | |
| » Starters: Glen Hobbie vs Ken Johnson | Eighth | 34½ out |
| Sunday, August 19 |
| » Lost to Cubs (47-78), 4-3 | Colt Stadium (25-43) | 45-77 | Lost 2 |
| » Starters: Bob Buhl vs Hal Woodeshick | Ninth | 35½ out |
| Monday, August 20 |
| » Lost to Phillies (59-68), 7-1 | Shibe Park (0-7) | 45-78 | Lost 3 |
| » Starters: Turk Farrell vs Dallas Green | Ninth | 35½ out |
| Tuesday, August 21 |
| » Lost to Phillies (60-68), 5-3 | Shibe Park (0-8) | 45-79 | Lost 4 |
| » Starters: Bob Bruce vs Art Mahaffey | Ninth | 36½ out |
| » Lost to Phillies (61-68), 7-4 | Shibe Park (0-9) | 45-80 | Lost 5 |
| » Starters: Jim Golden vs Jack Hamilton | Ninth | 36½ out |
| Wednesday, August 22 |
| » Lost to Pirates (73-53), 3-0 | Forbes Field (2-6) | 45-81 | Lost 6 |
| » Starters: George Brunet vs Tom Sturdivant | Ninth | 36½ out |
| Thursday, August 23 |
| » Lost to Pirates (74-53), 4-0 | Forbes Field (2-7) | 45-82 | Lost 7 |
| » Starters: Ken Johnson vs Vern Law | Ninth | 37½ out |
| Friday, August 24 |
| » Lost to Reds (80-49), 4-2 | Crosley Field (1-5) | 45-83 | Lost 8 |
| » Starters: Hal Woodeshick vs Bob Purkey | Ninth | 37½ out |
| Saturday, August 25 |
| » Lost to Reds (81-49), 7-6 | Crosley Field (1-6) | 45-84 | Lost 9 |
| » Starters: Turk Farrell vs Joey Jay | Ninth | 38½ out |
| Sunday, August 26 |
| » Defeated Reds (81-50), 2-1 | Crosley Field (2-6) | 46-84 | |
| » Starters: George Brunet vs Jim Maloney | Ninth | 38 out |
| » Defeated Reds (81-51), 6-4 | Crosley Field (3-6) | 47-84 | Won 2 |
| » Starters: Hal Woodeshick vs Jim O'Toole | Ninth | 38 out |
| Tuesday, August 28 |
| » Defeated Cardinals (71-61), 4-2 | Sportsman's Park III (3-5) | 48-84 | Won 3 |
| » Starters: Bob Bruce vs Ernie Broglio | Ninth | 38 out |
| Wednesday, August 29 |
| » Defeated Cardinals (71-62), 3-2 | Sportsman's Park III (4-5) | 49-84 | Won 4 |
| » Starters: Turk Farrell vs Bob Gibson | Eighth | 38 out |
| Saturday, September 1 |
| » Lost to Cubs (50-85), 4-3 | Wrigley Field (4-4) | 49-85 | |
| » Starters: George Brunet vs Dick Ellsworth | Ninth | 39 out |
| Sunday, September 2 |
| » Defeated Cubs (50-86), 3-1 | Wrigley Field (5-4) | 50-85 | |
| » Starters: Ken Johnson vs Bob Buhl | Eighth | 39 out |
| Monday, September 3 |
| » Lost to Phillies (67-74), 3-2 | Colt Stadium (25-44) | 50-86 | |
| » Starters: Art Mahaffey vs Turk Farrell | Ninth | 39½ out |
| » Lost to Phillies (68-74), 5-3 | Colt Stadium (25-45) | 50-87 | Lost 2 |
| » Starters: Jack Hamilton vs Hal Woodeshick | Ninth | 39½ out |
| Future Astro Dave Clark is born in Tupelo, MS. |
| Tuesday, September 4 |
| » Defeated Phillies (68-75), 4-1 | Colt Stadium (26-45) | 51-87 | |
| » Starters: Cal McLish vs Bob Bruce | Ninth | 39½ out |
| Wednesday, September 5 |
| » Defeated Pirates (83-57), 5-3 | Colt Stadium (27-45) | 52-87 | Won 2 |
| » Starters: Vern Law vs George Brunet | Eighth | 38½ out |
| » Major-league debuts: Dave Roberts (Astros) |
| Thursday, September 6 |
| » Defeated Pirates (83-58), 4-3 | Colt Stadium (28-45) | 53-87 | Won 3 |
| » Starters: Tom Sturdivant vs Ken Johnson | Eighth | 37½ out |
| Friday, September 7 |
| » Defeated Mets (35-107), 4-2 | Colt Stadium (29-45) | 54-87 | Won 4 |
| » Starters: Al Jackson vs Hal Woodeshick | Eighth | 36½ out |
| Saturday, September 8 |
| » Defeated Mets (35-108), 4-3 | Colt Stadium (30-45) | 55-87 | Won 5 |
| » Starters: Jay Hook vs George Brunet | Eighth | 36 out |
| » Defeated Mets (35-109), 6-5 | Colt Stadium (31-45) | 56-87 | Won 6 |
| » Starters: Roger Craig vs Turk Farrell | Eighth | 36 out |
| Sunday, September 9 |
| » Tied Mets, 7-7 | Colt Stadium (31-45) | 56-87 | |
| » Starters: Craig Anderson vs Bob Bruce | Eighth | 36½ out |
| Tuesday, September 11 |
| » Major-league debuts: Jake Gibbs (Yankees) |
| Wednesday, September 12 |
| » Lost to Dodgers (96-51), 1-0 | Colt Stadium (31-46) | 56-88 | |
| » Starters: Pete Richert vs Ken Johnson | Eighth | 38½ out |
| Thursday, September 13 |
| » Major-league debuts: Pete Smith (Red Sox) |
| Friday, September 14 |
| » Lost to Braves (76-73), 3-1 | County Stadium (3-4) | 56-89 | Lost 2 |
| » Starters: Turk Farrell vs Bob Hendley | Eighth | 39½ out |
| Saturday, September 15 |
| » Lost to Braves (77-73), 9-8 | County Stadium (3-5) | 56-90 | Lost 3 |
| » Starters: George Brunet vs Bob Shaw | Eighth | 40½ out |
| Sunday, September 16 |
| » Lost to Braves (78-73), 5-4 | County Stadium (3-6) | 56-91 | Lost 4 |
| » Starters: Bob Bruce vs Tony Cloninger | Eighth | 40½ out |
| Tuesday, September 18 |
| » Defeated Mets (37-112), 6-2 | Polo Grounds V (3-2) | 57-91 | |
| » Starters: Ken Johnson vs Al Jackson | Eighth | 38½ out |
| » Defeated Mets (37-113), 8-6 | Polo Grounds V (4-2) | 58-91 | Won 2 |
| » Starters: Dick Drott vs Larry Foss | Eighth | 38½ out |
| Wednesday, September 19 |
| » Major-league debuts: Bill Faul (Tigers) |
| Thursday, September 20 |
| » Defeated Mets (37-114), 7-2 | Polo Grounds V (5-2) | 59-91 | Won 3 |
| » Starters: Jim Golden vs Jay Hook | Eighth | 38 out |
| » Defeated Mets (37-115), 5-4 | Polo Grounds V (6-2) | 60-91 | Won 4 |
| » Starters: Turk Farrell vs Roger Craig | Eighth | 38 out |
| Friday, September 21 |
| » Lost to Giants (96-58), 11-5 | Colt Stadium (31-47) | 60-92 | |
| » Starters: Gaylord Perry vs George Brunet | Eighth | 38 out |
| Saturday, September 22 |
| » Defeated Giants (96-59), 6-5 | Colt Stadium (32-47) | 61-92 | |
| » Starters: Juan Marichal vs Ken Johnson | Eighth | 38 out |
| Sunday, September 23 |
| » Lost to Giants (97-59), 10-3 | Colt Stadium (32-48) | 61-93 | |
| » Starters: Billy O'Dell vs Bob Bruce | Eighth | 38 out |
| Tuesday, September 25 |
| » Defeated Dodgers (100-57), 3-2 | Dodger Stadium (3-4) | 62-93 | |
| » Starters: Turk Farrell vs Don Drysdale | Eighth | 37 out |
| Wednesday, September 26 |
| » Lost to Dodgers (101-57), 13-1 | Dodger Stadium (3-5) | 62-94 | |
| » Starters: George Brunet vs Johnny Podres | Seventh | 38 out |
| Thursday, September 27 |
| » Defeated Dodgers (101-58), 8-6 | Dodger Stadium (4-5) | 63-94 | |
| » Starters: Jim Golden vs Sandy Koufax | Seventh | 37 out |
| Saturday, September 29 |
| » Lost to Giants (100-60), 11-5 | Candlestick Park (4-3) | 63-95 | |
| » Starters: Ken Johnson vs Jack Sanford | Eighth | 36 out |
| » |