| Monday, January 30 |
| Former White Sox Aaron Ward dies in New Orleans, LA at the age of 65. |
| Thursday, February 9 |
| Future White Sox John Kruk is born in Charleston, WV. |
| Tuesday, February 21 |
| Future White Sox Joel Skinner is born in LaJolla, CA. |
| Wednesday, March 8 |
| Future White Sox Mark Salas is born in Montebello, CA. |
| Sunday, April 9 |
| Future White Sox Kirk McCaskill is born in Kapuskasing, ON. |
| Monday, April 10 |
| » Defeated Senators (0-1), 4-3 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Early Wynn vs Dick Donovan | First | -- |
| Friday, April 14 |
| » Lost to Tigers (1-1), 7-0 | Tiger Stadium (0-1) | 1-1 | |
| » Starters: Frank Baumann vs Frank Lary | Third | 1 out |
| Saturday, April 15 |
| » Lost to Tigers (2-1), 6-2 | Tiger Stadium (0-2) | 1-2 | Lost 2 |
| » Starters: Cal McLish vs Don Mossi | Third | 1 out |
| Wednesday, April 19 |
| » Lost to Senators (2-3), 7-2 | Comiskey Park I (0-1) | 1-3 | Lost 3 |
| » Starters: Ed Hobaugh vs Billy Pierce | Eighth | 3 out |
| » Major-league debuts: Ed Hobaugh (Senators) |
| Thursday, April 20 |
| » Defeated Senators (2-4), 6-1 | Comiskey Park I (1-1) | 2-3 | |
| » Starters: Hal Woodeshick vs Early Wynn | Fifth | 2½ out |
| Friday, April 21 |
| » Defeated Red Sox (2-3), 3-2 | Comiskey Park I (2-1) | 3-3 | Won 2 |
| » Starters: Bill Monbouquette vs Cal McLish | Fourth | 2 out |
| Former White Sox Lum Davenport dies in Dallas, TX at the age of 61. |
| Saturday, April 22 |
| » Lost to Red Sox (3-3), 7-6 | Comiskey Park I (2-2) | 3-4 | |
| » Starters: Ike Delock vs Frank Baumann | Sixth | 2½ out |
| Sunday, April 23 |
| » Lost to Red Sox (4-3), 4-3 | Comiskey Park I (2-3) | 3-5 | Lost 2 |
| » Starters: Tom Brewer vs Billy Pierce | Sixth | 3½ out |
| » Defeated Red Sox (4-4), 7-1 | Comiskey Park I (3-3) | 4-5 | |
| » Starters: Billy Muffett vs Bob Shaw | Sixth | 3½ out |
| Thursday, April 27 |
| » Defeated Athletics (3-6), 9-1 | Municipal Stadium (1-0) | 5-5 | Won 2 |
| » Starters: Early Wynn vs Bud Daley | Sixth | 3 out |
| Friday, April 28 |
| » Defeated Athletics (3-7), 4-2 | Municipal Stadium (2-0) | 6-5 | Won 3 |
| » Starters: Cal McLish vs Ray Herbert | Fourth | 2 out |
| Saturday, April 29 |
| » Lost to Athletics (4-7), 13-9 | Municipal Stadium (2-1) | 6-6 | |
| » Starters: Billy Pierce vs Jerry Walker | Fourth | 3 out |
| Sunday, April 30 |
| » Defeated Twins (9-6), 5-3 | Metropolitan Stadium (1-0) | 7-6 | |
| » Starters: Bob Shaw vs Jack Kralick | Fourth | 2½ out |
| Monday, May 1 |
| » Lost to Twins (10-6), 6-5 | Metropolitan Stadium (1-1) | 7-7 | |
| » Starters: Frank Baumann vs Chuck Stobbs | Fourth | 3 out |
| Tuesday, May 2 |
| » Lost to Indians (9-8), 3-2 | Cleveland Stadium (0-1) | 7-8 | Lost 2 |
| » Starters: Early Wynn vs Mudcat Grant | Fifth | 4 out |
| Wednesday, May 3 |
| » Lost to Indians (10-8), 4-3 | Cleveland Stadium (0-2) | 7-9 | Lost 3 |
| » Starters: Cal McLish vs Jim Perry | Fifth | 4 out |
| Friday, May 5 |
| » Lost to Tigers (13-5), 8-4 | Comiskey Park I (3-4) | 7-10 | Lost 4 |
| » Starters: Paul Foytack vs Bob Shaw | Fifth | 5½ out |
| Saturday, May 6 |
| » Lost to Tigers (14-5), 11-8 | Comiskey Park I (3-5) | 7-11 | Lost 5 |
| » Starters: Jim Bunning vs Billy Pierce | Seventh | 6½ out |
| Sunday, May 7 |
| » Lost to Tigers (15-5), 8-6 | Comiskey Park I (3-6) | 7-12 | Lost 6 |
| » Starters: Frank Lary vs Early Wynn | Eighth | 8½ out |
| » Lost to Tigers (16-5), 5-3 | Comiskey Park I (3-7) | 7-13 | Lost 7 |
| » Starters: Phil Regan vs Cal McLish | Eighth | 8½ out |
| Tuesday, May 9 |
| » Defeated Indians (11-11), 4-2 | Comiskey Park I (4-7) | 8-13 | |
| » Starters: Jim Perry vs Herb Score | Eighth | 8 out |
| Wednesday, May 10 |
| » Lost to Indians (12-11), 8-2 | Comiskey Park I (4-8) | 8-14 | |
| » Starters: Gary Bell vs Bob Shaw | Seventh | 9 out |
| Friday, May 12 |
| » Defeated Athletics (9-11), 2-1 | Comiskey Park I (5-8) | 9-14 | |
| » Starters: Norm Bass vs Early Wynn | Eighth | 8½ out |
| Saturday, May 13 |
| » Defeated Athletics (9-12), 10-1 | Comiskey Park I (6-8) | 10-14 | Won 2 |
| » Starters: Jerry Walker vs Billy Pierce | Eighth | 8½ out |
| Sunday, May 14 |
| » Defeated Athletics (9-13), 6-1 | Comiskey Park I (7-8) | 11-14 | Won 3 |
| » Starters: Ray Herbert vs Bob Shaw | Eighth | 7½ out |
| » Lost to Athletics (10-13), 5-3 | Comiskey Park I (7-9) | 11-15 | |
| » Starters: Joe Nuxhall vs Herb Score | Eighth | 7½ out |
| Monday, May 15 |
| » Lost to Twins (16-12), 5-0 | Comiskey Park I (7-10) | 11-16 | Lost 2 |
| » Starters: Camilo Pascual vs Cal McLish | Eighth | 8½ out |
| Tuesday, May 16 |
| » Defeated Twins (16-13), 5-4 | Comiskey Park I (8-10) | 12-16 | |
| » Starters: Pedro Ramos vs Early Wynn | Eighth | 8½ out |
| Thursday, May 18 |
| » Defeated Angels (9-19), 6-4 | Wrigley Field (1-0) | 13-16 | Won 2 |
| » Starters: Billy Pierce vs Ron Kline | Seventh | 8 out |
| Friday, May 19 |
| » Lost to Angels (10-19), 4-3 | Wrigley Field (1-1) | 13-17 | |
| » Starters: Herb Score vs Jerry Casale | Seventh | 9 out |
| » Lost to Angels (11-19), 5-3 | Wrigley Field (1-2) | 13-18 | Lost 2 |
| » Starters: Bob Shaw vs Ken McBride | Seventh | 9 out |
| Sunday, May 21 |
| » Defeated Red Sox (13-18), 6-5 | Fenway Park (1-0) | 14-18 | |
| » Starters: Early Wynn vs Ike Delock | Ninth | 9 out |
| » Lost to Red Sox (14-18), 4-1 | Fenway Park (1-1) | 14-19 | |
| » Starters: Cal McLish vs Don Schwall | Ninth | 9 out |
| » Major-league debuts: Don Schwall (Red Sox) |
| Monday, May 22 |
| » Lost to Red Sox (15-18), 4-1 | Fenway Park (1-2) | 14-20 | Lost 2 |
| » Starters: Frank Baumann vs Bill Monbouquette | Ninth | 10 out |
| Tuesday, May 23 |
| » Lost to Orioles (19-18), 3-1 | Memorial Stadium (0-1) | 14-21 | Lost 3 |
| » Starters: Billy Pierce vs Billy Hoeft | Ninth | 11 out |
| Wednesday, May 24 |
| » Lost to Orioles (20-18), 2-1 | Memorial Stadium (0-2) | 14-22 | Lost 4 |
| » Starters: Bob Shaw vs Hal Brown | Ninth | 12½ out |
| » Lost to Orioles (21-18), 5-3 | Memorial Stadium (0-3) | 14-23 | Lost 5 |
| » Starters: Russ Kemmerer vs Dick Hall | Ninth | 12½ out |
| Thursday, May 25 |
| » Lost to Orioles (22-18), 6-4 | Memorial Stadium (0-4) | 14-24 | Lost 6 |
| » Starters: Herb Score vs Steve Barber | Ninth | 12½ out |
| Sunday, May 28 |
| » Defeated Yankees (20-16), 14-9 | Yankee Stadium (1-0) | 15-24 | |
| » Starters: Early Wynn vs Bob Turley | Tenth | 12 out |
| » Lost to Yankees (21-16), 5-3 | Yankee Stadium (1-1) | 15-25 | |
| » Starters: Cal McLish vs Art Ditmar | Tenth | 12 out |
| Tuesday, May 30 |
| » Lost to Orioles (24-19), 6-0 | Comiskey Park I (8-11) | 15-26 | Lost 2 |
| » Starters: Steve Barber vs Bob Shaw | Tenth | 13 out |
| » Lost to Orioles (25-19), 2-1 | Comiskey Park I (8-12) | 15-27 | Lost 3 |
| » Starters: Hal Brown vs Billy Pierce | Tenth | 13 out |
| Wednesday, May 31 |
| » Defeated Orioles (25-20), 9-4 | Comiskey Park I (9-12) | 16-27 | |
| » Starters: Chuck Estrada vs Frank Baumann | Tenth | 12 out |
| Friday, June 2 |
| » Lost to Yankees (24-18), 6-2 | Comiskey Park I (9-13) | 16-28 | |
| » Starters: Whitey Ford vs Cal McLish | Tenth | 13 out |
| Saturday, June 3 |
| » Defeated Yankees (24-19), 6-5 | Comiskey Park I (10-13) | 17-28 | |
| » Starters: Ralph Terry vs Bob Shaw | Ninth | 13 out |
| Sunday, June 4 |
| » Lost to Yankees (25-19), 10-1 | Comiskey Park I (10-14) | 17-29 | |
| » Starters: Bill Stafford vs Billy Pierce | Ninth | 14½ out |
| Monday, June 5 |
| » Defeated Tigers (33-17), 8-0 | Comiskey Park I (11-14) | 18-29 | |
| » Starters: Phil Regan vs Frank Baumann | Ninth | 13½ out |
| Tuesday, June 6 |
| » Defeated Tigers (33-18), 7-1 | Comiskey Park I (12-14) | 19-29 | Won 2 |
| » Starters: Jim Bunning vs Early Wynn | Eighth | 12½ out |
| Friday, June 9 |
| » Lost to Senators (25-28), 1-0 | Griffith Stadium (1-1) | 19-30 | |
| » Starters: Cal McLish vs Dick Donovan | Ninth | 14½ out |
| » Lost to Senators (26-28), 10-9 | Griffith Stadium (1-2) | 19-31 | Lost 2 |
| » Starters: Bob Shaw vs Bennie Daniels | Ninth | 14½ out |
| Saturday, June 10 |
| » Lost to Senators (27-28), 4-3 | Griffith Stadium (1-3) | 19-32 | Lost 3 |
| » Starters: Juan Pizarro vs Ed Hobaugh | Tenth | 14½ out |
| Sunday, June 11 |
| » Lost to Orioles (29-26), 8-2 | Memorial Stadium (0-5) | 19-33 | Lost 4 |
| » Starters: Frank Baumann vs Chuck Estrada | Ninth | 15½ out |
| » Defeated Orioles (29-27), 7-1 | Memorial Stadium (1-5) | 20-33 | |
| » Starters: Billy Pierce vs Steve Barber | Ninth | 15½ out |
| Monday, June 12 |
| » Defeated Orioles (29-28), 9-8 | Memorial Stadium (2-5) | 21-33 | Won 2 |
| » Starters: Russ Kemmerer vs Billy Hoeft | Eighth | 14½ out |
| Tuesday, June 13 |
| » Defeated Angels (21-37), 2-1 | Comiskey Park I (13-14) | 22-33 | Won 3 |
| » Starters: Ryne Duren vs Cal McLish | Eighth | 14 out |
| » Defeated Angels (21-38), 10-2 | Comiskey Park I (14-14) | 23-33 | Won 4 |
| » Starters: Ron Kline vs Juan Pizarro | Eighth | 14 out |
| Wednesday, June 14 |
| » Defeated Angels (21-39), 4-1 | Comiskey Park I (15-14) | 24-33 | Won 5 |
| » Starters: Johnny James vs Ray Herbert | Seventh | 12½ out |
| » Defeated Angels (21-40), 9-8 | Comiskey Park I (16-14) | 25-33 | Won 6 |
| » Starters: Ron Moeller vs Frank Baumann | Seventh | 12½ out |
| Thursday, June 15 |
| » Defeated Angels (21-41), 3-2 | Comiskey Park I (17-14) | 26-33 | Won 7 |
| » Starters: Eli Grba vs Billy Pierce | Sixth | 11½ out |
| Friday, June 16 |
| » Lost to Twins (24-36), 6-1 | Comiskey Park I (17-15) | 26-34 | |
| » Starters: Danny McDevitt vs Don Larsen | Sixth | 12½ out |
| » Major-league debuts: Rich Rollins (Twins) |
| Saturday, June 17 |
| » Defeated Twins (24-37), 5-1 | Comiskey Park I (18-15) | 27-34 | |
| » Starters: Jim Kaat vs Juan Pizarro | Eighth | 12½ out |
| Sunday, June 18 |
| » Defeated Twins (24-38), 4-3 | Comiskey Park I (19-15) | 28-34 | Won 2 |
| » Starters: Bert Cueto vs Cal McLish | Seventh | 11 out |
| » Defeated Twins (24-39), 10-7 | Comiskey Park I (20-15) | 29-34 | Won 3 |
| » Starters: Camilo Pascual vs Ray Herbert | Seventh | 11 out |
| Future White Sox Tom McCarthy is born in Lundstahl, W.Germany. |
| Tuesday, June 20 |
| » Defeated Indians (40-25), 5-3 | Comiskey Park I (21-15) | 30-34 | Won 4 |
| » Starters: Mudcat Grant vs Billy Pierce | Sixth | 11 out |
| Wednesday, June 21 |
| » Defeated Indians (40-26), 15-3 | Comiskey Park I (22-15) | 31-34 | Won 5 |
| » Starters: Gary Bell vs Frank Baumann | Sixth | 10 out |
| » Defeated Indians (40-27), 11-1 | Comiskey Park I (23-15) | 32-34 | Won 6 |
| » Starters: Wynn Hawkins vs Juan Pizarro | Sixth | 10 out |
| Friday, June 23 |
| » Defeated Senators (30-37), 4-3 | Comiskey Park I (24-15) | 33-34 | Won 7 |
| » Starters: Joe McClain vs Ray Herbert | Sixth | 10½ out |
| Saturday, June 24 |
| » Defeated Senators (30-38), 12-6 | Comiskey Park I (25-15) | 34-34 | Won 8 |
| » Starters: Carl Mathias vs Cal McLish | Sixth | 10½ out |
| Sunday, June 25 |
| » Defeated Senators (30-39), 7-3 | Comiskey Park I (26-15) | 35-34 | Won 9 |
| » Starters: Dick Donovan vs Billy Pierce | Fifth | 9½ out |
| » Defeated Senators (30-40), 6-3 | Comiskey Park I (27-15) | 36-34 | Won 10 |
| » Starters: Johnny Klippstein vs Early Wynn | Fifth | 9½ out |
| Tuesday, June 27 |
| » Defeated Tigers (45-25), 6-5 | Tiger Stadium (1-2) | 37-34 | Won 11 |
| » Starters: Frank Baumann vs Jerry Casale | Fourth | 7½ out |
| » Defeated Tigers (45-26), 11-1 | Tiger Stadium (2-2) | 38-34 | Won 12 |
| » Starters: Juan Pizarro vs Phil Regan | Fourth | 7½ out |
| Wednesday, June 28 |
| » Lost to Tigers (46-26), 12-5 | Tiger Stadium (2-3) | 38-35 | |
| » Starters: Ray Herbert vs Don Mossi | Fifth | 8½ out |
| Thursday, June 29 |
| » Lost to Tigers (47-26), 5-2 | Tiger Stadium (2-4) | 38-36 | Lost 2 |
| » Starters: Cal McLish vs Frank Lary | Sixth | 9½ out |
| Friday, June 30 |
| » Lost to Angels (28-47), 10-3 | Wrigley Field (1-3) | 38-37 | Lost 3 |
| » Starters: Billy Pierce vs Ken McBride | Sixth | 10½ out |
| Saturday, July 1 |
| » Defeated Angels (28-48), 6-4 | Wrigley Field (2-3) | 39-37 | |
| » Starters: Early Wynn vs Eli Grba | Fifth | 10½ out |
| Sunday, July 2 |
| » Lost to Angels (29-48), 8-3 | Wrigley Field (2-4) | 39-38 | |
| » Starters: Juan Pizarro vs Johnny James | Fifth | 10½ out |
| Monday, July 3 |
| » Lost to Twins (31-46), 7-6 | Metropolitan Stadium (1-2) | 39-39 | Lost 2 |
| » Starters: Ray Herbert vs Camilo Pascual | Fifth | 11 out |
| Tuesday, July 4 |
| » Lost to Twins (32-46), 6-4 | Metropolitan Stadium (1-3) | 39-40 | Lost 3 |
| » Starters: Billy Pierce vs Bert Cueto | Fifth | 12 out |
| » Lost to Twins (33-46), 4-2 | Metropolitan Stadium (1-4) | 39-41 | Lost 4 |
| » Starters: Cal McLish vs Jack Kralick | Fifth | 12 out |
| Wednesday, July 5 |
| » Lost to Athletics (31-47), 8-3 | Municipal Stadium (2-2) | 39-42 | Lost 5 |
| » Starters: Juan Pizarro vs Bob Shaw | Sixth | 12½ out |
| Thursday, July 6 |
| » Defeated Athletics (31-48), 4-3 | Municipal Stadium (3-2) | 40-42 | |
| » Starters: Early Wynn vs Jerry Walker | Fifth | 12½ out |
| Friday, July 7 |
| » Lost to Indians (46-37), 9-0 | Cleveland Stadium (0-3) | 40-43 | |
| » Starters: Ray Herbert vs Barry Latman | Fourth | 13 out |
| Saturday, July 8 |
| » Lost to Indians (47-37), 3-2 | Cleveland Stadium (0-4) | 40-44 | Lost 2 |
| » Starters: Juan Pizarro vs Mudcat Grant | Fourth | 14 out |
| Sunday, July 9 |
| » Defeated Indians (47-38), 7-5 | Cleveland Stadium (1-4) | 41-44 | |
| » Starters: Billy Pierce vs Wynn Hawkins | Fifth | 13½ out |
| » Defeated Indians (47-39), 9-8 | Cleveland Stadium (2-4) | 42-44 | Won 2 |
| » Starters: Cal McLish vs Jim Perry | Fifth | 13½ out |
| Thursday, July 13 |
| » Lost to Yankees (54-29), 6-2 | Comiskey Park I (27-16) | 42-45 | |
| » Starters: Bill Stafford vs Early Wynn | Fifth | 14 out |
| Friday, July 14 |
| » Defeated Yankees (54-30), 6-1 | Comiskey Park I (28-16) | 43-45 | |
| » Starters: Rollie Sheldon vs Juan Pizarro | Fifth | 13 out |
| Saturday, July 15 |
| » Lost to Yankees (55-30), 9-8 | Comiskey Park I (28-17) | 43-46 | |
| » Starters: Ralph Terry vs Ray Herbert | Fifth | 14 out |
| Sunday, July 16 |
| » Defeated Red Sox (42-47), 4-3 | Comiskey Park I (29-17) | 44-46 | |
| » Starters: Tracy Stallard vs Billy Pierce | Fifth | 15 out |
| » Lost to Red Sox (43-47), 5-3 | Comiskey Park I (29-18) | 44-47 | |
| » Starters: Ike Delock vs Cal McLish | Fifth | 15 out |
| Monday, July 17 |
| » Defeated Red Sox (43-48), 4-1 | Comiskey Park I (30-18) | 45-47 | |
| » Starters: Galen Cisco vs Early Wynn | Fifth | 15 out |
| Tuesday, July 18 |
| » Defeated Athletics (33-57), 4-3 | Comiskey Park I (31-18) | 46-47 | Won 2 |
| » Starters: Ed Rakow vs Juan Pizarro | Fifth | 14½ out |
| Wednesday, July 19 |
| » Defeated Athletics (33-58), 6-5 | Comiskey Park I (32-18) | 47-47 | Won 3 |
| » Starters: Bob Shaw vs Ray Herbert | Fifth | 13 out |
| Saturday, July 22 |
| » Defeated Orioles (51-43), 7-4 | Comiskey Park I (33-18) | 48-47 | Won 4 |
| » Starters: Dick Hall vs Early Wynn | Fifth | 13 out |
| » Defeated Orioles (51-44), 11-4 | Comiskey Park I (34-18) | 49-47 | Won 5 |
| » Starters: Milt Pappas vs Billy Pierce | Fifth | 13 out |
| Sunday, July 23 |
| » Defeated Orioles (51-45), 5-2 | Comiskey Park I (35-18) | 50-47 | Won 6 |
| » Starters: Chuck Estrada vs Cal McLish | Fifth | 12½ out |
| Tuesday, July 25 |
| » Lost to Yankees (61-33), 5-1 | Yankee Stadium (1-2) | 50-48 | |
| » Starters: Frank Baumann vs Whitey Ford | Fifth | 14 out |
| » Lost to Yankees (62-33), 12-0 | Yankee Stadium (1-3) | 50-49 | Lost 2 |
| » Starters: Juan Pizarro vs Bill Stafford | Fifth | 14 out |
| Wednesday, July 26 |
| » Lost to Yankees (63-33), 5-2 | Yankee Stadium (1-4) | 50-50 | Lost 3 |
| » Starters: Ray Herbert vs Rollie Sheldon | Fifth | 15 out |
| Thursday, July 27 |
| » Lost to Yankees (64-33), 4-3 | Yankee Stadium (1-5) | 50-51 | Lost 4 |
| » Starters: Billy Pierce vs Ralph Terry | Fifth | 16 out |
| Future White Sox Nelson Santovenia is born in Pinar Del Rio, Cuba. |
| Friday, July 28 |
| » Lost to Red Sox (46-57), 8-3 | Fenway Park (1-3) | 50-52 | Lost 5 |
| » Starters: Cal McLish vs Don Schwall | Fifth | 16 out |
| Sunday, July 30 |
| » Defeated Red Sox (46-58), 4-2 | Fenway Park (2-3) | 51-52 | |
| » Starters: Frank Baumann vs Bill Monbouquette | Fifth | 15½ out |
| » Lost to Red Sox (47-58), 9-8 | Fenway Park (2-4) | 51-53 | |
| » Starters: Juan Pizarro vs Gene Conley | Fifth | 15½ out |
| Wednesday, August 2 |
| » Lost to Indians (56-49), 3-2 | Cleveland Stadium (2-5) | 51-54 | Lost 2 |
| » Starters: Ray Herbert vs Mudcat Grant | Fifth | 16½ out |
| » Defeated Indians (56-50), 8-4 | Cleveland Stadium (3-5) | 52-54 | |
| » Starters: Cal McLish vs Jim Perry | Fifth | 16½ out |
| Thursday, August 3 |
| » Defeated Indians (56-51), 8-6 | Cleveland Stadium (4-5) | 53-54 | Won 2 |
| » Starters: Frank Baumann vs Wynn Hawkins | Fifth | 15½ out |
| Saturday, August 5 |
| » Defeated Senators (46-59), 8-3 | Comiskey Park I (36-18) | 54-54 | Won 3 |
| » Starters: Gabe Gabler vs Juan Pizarro | Fifth | 16 out |
| Sunday, August 6 |
| » Defeated Senators (46-60), 5-4 | Comiskey Park I (37-18) | 55-54 | Won 4 |
| » Starters: Marty Kutyna vs Ray Herbert | Fifth | 16 out |
| » Defeated Senators (46-61), 3-2 | Comiskey Park I (38-18) | 56-54 | Won 5 |
| » Starters: Joe McClain vs Billy Pierce | Fifth | 16 out |
| Tuesday, August 8 |
| » Lost to Tigers (70-40), 3-0 | Comiskey Park I (38-19) | 56-55 | |
| » Starters: Jim Bunning vs Frank Baumann | Fifth | 17½ out |
| Wednesday, August 9 |
| » Lost to Tigers (71-40), 8-2 | Comiskey Park I (38-20) | 56-56 | Lost 2 |
| » Starters: Frank Lary vs Cal McLish | Fifth | 18½ out |
| Thursday, August 10 |
| » Lost to Tigers (72-40), 3-2 | Comiskey Park I (38-21) | 56-57 | Lost 3 |
| » Starters: Don Mossi vs Juan Pizarro | Fifth | 19½ out |
| Friday, August 11 |
| » Defeated Athletics (42-71), 1-0 | Comiskey Park I (39-21) | 57-57 | |
| » Starters: Jim Archer vs Billy Pierce | Fifth | 19½ out |
| Saturday, August 12 |
| » Defeated Athletics (42-72), 2-1 | Comiskey Park I (40-21) | 58-57 | Won 2 |
| » Starters: Bob Shaw vs Ray Herbert | Fifth | 18½ out |
| Sunday, August 13 |
| » Defeated Athletics (42-73), 9-3 | Comiskey Park I (41-21) | 59-57 | Won 3 |
| » Starters: Norm Bass vs Frank Baumann | Fifth | 18 out |
| Tuesday, August 15 |
| » Defeated Yankees (77-40), 2-1 | Yankee Stadium (2-5) | 60-57 | Won 4 |
| » Starters: Juan Pizarro vs Whitey Ford | Fourth | 17 out |
| Wednesday, August 16 |
| » Lost to Yankees (78-40), 5-4 | Yankee Stadium (2-6) | 60-58 | |
| » Starters: Billy Pierce vs Rollie Sheldon | Fifth | 18 out |
| Thursday, August 17 |
| » Lost to Yankees (79-40), 5-3 | Yankee Stadium (2-7) | 60-59 | Lost 2 |
| » Starters: Frank Baumann vs Bill Stafford | Fifth | 19 out |
| Friday, August 18 |
| » Lost to Athletics (44-75), 3-1 | Municipal Stadium (3-3) | 60-60 | Lost 3 |
| » Starters: Ray Herbert vs Bob Shaw | Fifth | 19 out |
| Saturday, August 19 |
| » Defeated Athletics (44-76), 5-3 | Municipal Stadium (4-3) | 61-60 | |
| » Starters: Cal McLish vs Jerry Walker | Fifth | 19 out |
| Sunday, August 20 |
| » Defeated Athletics (44-77), 5-3 | Municipal Stadium (5-3) | 62-60 | Won 2 |
| » Starters: Billy Pierce vs Jim Archer | Fourth | 19 out |
| » Defeated Athletics (44-78), 7-0 | Municipal Stadium (6-3) | 63-60 | Won 3 |
| » Starters: Juan Pizarro vs Art Ditmar | Fourth | 19 out |
| Tuesday, August 22 |
| » Defeated Twins (53-70), 4-3 | Comiskey Park I (42-21) | 64-60 | Won 4 |
| » Starters: Pedro Ramos vs Frank Baumann | Fourth | 18 out |
| Wednesday, August 23 |
| » Lost to Twins (54-70), 4-0 | Comiskey Park I (42-22) | 64-61 | |
| » Starters: Camilo Pascual vs Cal McLish | Fourth | 19 out |
| Thursday, August 24 |
| » Lost to Twins (55-70), 3-0 | Comiskey Park I (42-23) | 64-62 | Lost 2 |
| » Starters: Jim Kaat vs Ray Herbert | Fourth | 19 out |
| Friday, August 25 |
| » Defeated Indians (64-63), 3-2 | Comiskey Park I (43-23) | 65-62 | |
| » Starters: Gary Bell vs Juan Pizarro | Fourth | 19 out |
| Saturday, August 26 |
| » Defeated Indians (64-64), 10-5 | Comiskey Park I (44-23) | 66-62 | Won 2 |
| » Starters: Wynn Hawkins vs Frank Baumann | Fourth | 19 out |
| Sunday, August 27 |
| » Defeated Indians (64-65), 10-6 | Comiskey Park I (45-23) | 67-62 | Won 3 |
| » Starters: Mudcat Grant vs Billy Pierce | Fourth | 18½ out |
| » Defeated Indians (64-66), 9-3 | Comiskey Park I (46-23) | 68-62 | Won 4 |
| » Starters: Barry Latman vs Cal McLish | Fourth | 18½ out |
| Tuesday, August 29 |
| » Defeated Tigers (85-46), 4-3 | Tiger Stadium (3-4) | 69-62 | Won 5 |
| » Starters: Ray Herbert vs Frank Lary | Fourth | 17½ out |
| Wednesday, August 30 |
| » Defeated Tigers (85-47), 7-4 | Tiger Stadium (4-4) | 70-62 | Won 6 |
| » Starters: Juan Pizarro vs Jim Bunning | Fourth | 17½ out |
| Thursday, August 31 |
| » Lost to Tigers (86-47), 8-2 | Tiger Stadium (4-5) | 70-63 | |
| » Starters: Frank Baumann vs Paul Foytack | Fourth | 17½ out |
| Friday, September 1 |
| » Defeated Senators (50-81), 3-2 | Griffith Stadium (2-3) | 71-63 | |
| » Starters: Cal McLish vs Ed Hobaugh | Fourth | 18 out |
| » Lost to Senators (51-81), 5-1 | Griffith Stadium (2-4) | 71-64 | |
| » Starters: Billy Pierce vs Joe McClain | Fourth | 18 out |
| Saturday, September 2 |
| » Defeated Senators (51-82), 12-7 | Griffith Stadium (3-4) | 72-64 | |
| » Starters: Don Larsen vs Tom Cheney | Fourth | 18 out |
| Sunday, September 3 |
| » Defeated Senators (51-83), 5-4 | Griffith Stadium (4-4) | 73-64 | Won 2 |
| » Starters: Ray Herbert vs Marty Kutyna | Fourth | 17½ out |
| » Defeated Senators (51-84), 4-1 | Griffith Stadium (5-4) | 74-64 | Won 3 |
| » Starters: Juan Pizarro vs Gabe Gabler | Fourth | 17½ out |
| Monday, September 4 |
| » Lost to Twins (59-76), 9-5 | Metropolitan Stadium (1-5) | 74-65 | |
| » Starters: Frank Baumann vs Al Schroll | Fourth | 18½ out |
| » Defeated Twins (59-77), 9-5 | Metropolitan Stadium (2-5) | 75-65 | |
| » Starters: Cal McLish vs Jim Kaat | Fourth | 18½ out |
| » Major-league debuts: Joe Horlen (White Sox) |
| Tuesday, September 5 |
| » Tied Twins, 3-3 | Metropolitan Stadium (2-5) | 75-65 | |
| » Starters: Billy Pierce vs Jack Kralick | Fourth | 19 out |
| » Major-league debuts: Mike Hershberger (White Sox) |
| Wednesday, September 6 |
| » Defeated Twins (59-78), 6-3 | Metropolitan Stadium (3-5) | 76-65 | Won 2 |
| » Starters: Juan Pizarro vs Pedro Ramos | Fourth | 18½ out |
| » Defeated Twins (59-79), 4-2 | Metropolitan Stadium (4-5) | 77-65 | Won 3 |
| » Starters: Don Larsen vs Camilo Pascual | Fourth | 18½ out |
| Friday, September 8 |
| » Defeated Angels (61-80), 5-3 | Wrigley Field (3-4) | 78-65 | Won 4 |
| » Starters: Ray Herbert vs Ken McBride | Fourth | 19 out |
| Saturday, September 9 |
| » Lost to Angels (62-80), 6-2 | Wrigley Field (3-5) | 78-66 | |
| » Starters: Joe Horlen vs Eli Grba | Fourth | 20 out |
| Sunday, September 10 |
| » Lost to Angels (63-80), 4-3 | Wrigley Field (3-6) | 78-67 | Lost 2 |
| » Starters: Juan Pizarro vs Jack Spring | Fourth | 21½ out |
| Tuesday, September 12 |
| » Lost to Yankees (100-45), 4-3 | Comiskey Park I (46-24) | 78-68 | Lost 3 |
| » Starters: Ralph Terry vs Billy Pierce | Fourth | 22½ out |
| Thursday, September 14 |
| » Defeated Yankees (100-46), 8-3 | Comiskey Park I (47-24) | 79-68 | |
| » Starters: Rollie Sheldon vs Ray Herbert | Fourth | 20½ out |
| » Defeated Yankees (100-47), 4-3 | Comiskey Park I (48-24) | 80-68 | Won 2 |
| » Starters: Jim Coates vs Juan Pizarro | Fourth | 20½ out |
| Friday, September 15 |
| » Lost to Angels (65-82), 9-5 | Comiskey Park I (48-25) | 80-69 | |
| » Starters: Eli Grba vs Joe Horlen | Fourth | 21 out |
| Saturday, September 16 |
| » Lost to Angels (66-82), 11-4 | Comiskey Park I (48-26) | 80-70 | Lost 2 |
| » Starters: Jack Spring vs Cal McLish | Fourth | 21 out |
| Sunday, September 17 |
| » Defeated Angels (66-83), 8-1 | Comiskey Park I (49-26) | 81-70 | |
| » Starters: Dean Chance vs Frank Baumann | Fourth | 20½ out |
| » Defeated Angels (66-84), 4-3 | Comiskey Park I (50-26) | 82-70 | Won 2 |
| » Starters: Ron Moeller vs Billy Pierce | Fourth | 20½ out |
| Tuesday, September 19 |
| » Defeated Red Sox (73-80), 5-1 | Comiskey Park I (51-26) | 83-70 | Won 3 |
| » Starters: Tracy Stallard vs Juan Pizarro | Fourth | 20 out |
| Wednesday, September 20 |
| » Defeated Red Sox (73-81), 3-1 | Comiskey Park I (52-26) | 84-70 | Won 4 |
| » Starters: Gene Conley vs Ray Herbert | Fourth | 20 out |
| Friday, September 22 |
| » Lost to Orioles (91-65), 8-6 | Comiskey Park I (52-27) | 84-71 | |
| » Starters: Chuck Estrada vs Frank Baumann | Fourth | 20 out |
| Sunday, September 24 |
| » Defeated Orioles (91-66), 8-7 | Comiskey Park I (53-27) | 85-71 | |
| » Starters: Steve Barber vs Joe Horlen | Fourth | 20 out |
| » Lost to Orioles (92-66), 5-3 | Comiskey Park I (53-28) | 85-72 | |
| » Starters: Billy Hoeft vs Juan Pizarro | Fourth | 20 out |
| Tuesday, September 26 |
| » Defeated Red Sox (74-83), 7-5 | Fenway Park (3-4) | 86-72 | |
| » Starters: Ray Herbert vs Gene Conley | Fourth | 20½ out |
| » Lost to Red Sox (75-83), 7-5 | Fenway Park (3-5) | 86-73 | |
| » Starters: Frank Baumann vs Ike Delock | Fourth | 20½ out |
| Wednesday, September 27 |
| » Lost to Red Sox (76-83), 6-4 | Fenway Park (3-6) | 86-74 | Lost 2 |
| » Starters: Joe Horlen vs Tom Brewer | Fourth | 20½ out |
| Friday, September 29 |
| » Lost to Orioles (94-67), 3-2 | Memorial Stadium (2-6) | 86-75 | Lost 3 |
| » Starters: Juan Pizarro vs Chuck Estrada | Fourth | 21½ out |
| Saturday, September 30 |
| » Lost to Orioles (95-67), 4-3 | Memorial Stadium (2-7) | 86-76 | Lost 4 |
| » Starters: Herb Score vs Hal Brown | Fourth | 22½ out |
| Tuesday, October 17 |
| Future White Sox Dan Pasqua is born in Yonkers, NY. |
| Thursday, October 19 |
| Future White Sox Tim Belcher is born in Mount Gilead, OH. |
| Saturday, October 28 |
| Future White Sox Bob Melvin is born in Palo Alto, CA. |
| Sunday, November 5 |
| Future White Sox Fred Manrique is born in Edo Bolivar, Venezuela. |
| Saturday, December 9 |
| Future White Sox Bruce Tanner is born in New Castle, PA. |
| Sunday, December 17 |
| Former White Sox Ping Bodie dies in San Francisco, CA at the age of 75. |
Game information provided by Retrosheet (www.retrosheet.org) |