| Friday, February 3 |
| Future Twin Fred Toliver is born in Natchez, MS. |
| Wednesday, February 15 |
| Future Twin Mark Davidson is born in Knoxville, TN. |
| Wednesday, March 8 |
| Future Twin Mark Salas is born in Montebello, CA. |
| Saturday, March 11 |
| Future Twin Bryan Oelkers is born in Zaragoza, Spain. |
| Tuesday, March 14 |
| Future Twin Kirby Puckett is born in Chicago, IL. |
| Monday, April 3 |
| Future Twin Doug Baker is born in Fullerton, CA. |
| Tuesday, April 11 |
| » Defeated Yankees (0-1), 6-0 | Yankee Stadium (1-0) | 1-0 | |
| » Starters: Pedro Ramos vs Whitey Ford | First | -- |
| Friday, April 14 |
| » Defeated Orioles (0-2), 3-2 | Memorial Stadium (1-0) | 2-0 | Won 2 |
| » Starters: Camilo Pascual vs Jack Fisher | First | -- |
| Saturday, April 15 |
| » Lost to Orioles (1-2), 8-0 | Memorial Stadium (1-1) | 2-1 | |
| » Starters: Chuck Stobbs vs Steve Barber | First | -- |
| » Major-league debuts: Lee Stange (Twins) |
| Sunday, April 16 |
| » Defeated Orioles (1-3), 10-5 | Memorial Stadium (2-1) | 3-1 | |
| » Starters: Pedro Ramos vs Chuck Estrada | First | -- |
| » Defeated Orioles (1-4), 6-4 | Memorial Stadium (3-1) | 4-1 | Won 2 |
| » Starters: Jack Kralick vs Hal Brown | First | -- |
| » Major-league debuts: Bill Pleis (Twins) |
| Tuesday, April 18 |
| » Defeated Red Sox (2-2), 3-2 | Fenway Park (1-0) | 5-1 | Won 3 |
| » Starters: Jim Kaat vs Billy Muffett | First | -- |
| Wednesday, April 19 |
| » Major-league debuts: Bubba Morton and Mike Roarke (Tigers) |
| Friday, April 21 |
| » Lost to Senators (3-4), 5-3 | Metropolitan Stadium (0-1) | 5-2 | |
| » Starters: Joe McClain vs Camilo Pascual | Second | ½ out |
| Saturday, April 22 |
| » Defeated Senators (3-5), 5-4 | Metropolitan Stadium (1-1) | 6-2 | |
| » Starters: Bennie Daniels vs Pedro Ramos | Second | 1 out |
| Sunday, April 23 |
| » Defeated Senators (3-6), 1-0 | Metropolitan Stadium (2-1) | 7-2 | Won 2 |
| » Starters: Dick Donovan vs Jack Kralick | Second | ½ out |
| Monday, April 24 |
| » Defeated Athletics (2-5), 10-6 | Municipal Stadium (1-0) | 8-2 | Won 3 |
| » Starters: Jim Kaat vs Don Larsen | Second | ½ out |
| Tuesday, April 25 |
| » Lost to Athletics (3-5), 20-2 | Municipal Stadium (1-1) | 8-3 | |
| » Starters: Ted Sadowski vs Norm Bass | Second | 1 out |
| » Major-league debuts: Fred Bruckbauer (Twins) |
| Wednesday, April 26 |
| » Major-league debuts: Joe Grzenda (Tigers) |
| Thursday, April 27 |
| » Defeated Angels (1-8), 4-2 | Wrigley Field (1-0) | 9-3 | |
| » Starters: Camilo Pascual vs Eli Grba | First | -- |
| Friday, April 28 |
| » Lost to Angels (2-8), 6-5 | Wrigley Field (1-1) | 9-4 | |
| » Starters: Pedro Ramos vs Ron Kline | Second | 1 out |
| Saturday, April 29 |
| » Lost to Angels (3-8), 4-1 | Wrigley Field (1-2) | 9-5 | Lost 2 |
| » Starters: Jim Kaat vs Ken McBride | Third | 1 out |
| Sunday, April 30 |
| » Lost to White Sox (7-6), 5-3 | Metropolitan Stadium (2-2) | 9-6 | Lost 3 |
| » Starters: Bob Shaw vs Jack Kralick | Third | 1½ out |
| Monday, May 1 |
| » Defeated White Sox (7-7), 6-5 | Metropolitan Stadium (3-2) | 10-6 | |
| » Starters: Frank Baumann vs Chuck Stobbs | Third | 1 out |
| Tuesday, May 2 |
| » Lost to Yankees (10-5), 6-4 | Metropolitan Stadium (3-3) | 10-7 | |
| » Starters: Art Ditmar vs Camilo Pascual | Third | 2 out |
| Wednesday, May 3 |
| » Lost to Yankees (11-5), 7-3 | Metropolitan Stadium (3-4) | 10-8 | Lost 2 |
| » Starters: Bob Turley vs Pedro Ramos | Second | 2 out |
| Thursday, May 4 |
| » Lost to Yankees (12-5), 5-2 | Metropolitan Stadium (3-5) | 10-9 | Lost 3 |
| » Starters: Whitey Ford vs Jim Kaat | Third | 3 out |
| Friday, May 5 |
| » Defeated Red Sox (7-10), 5-1 | Metropolitan Stadium (4-5) | 11-9 | |
| » Starters: Tom Brewer vs Jack Kralick | Second | 3 out |
| Sunday, May 7 |
| » Lost to Red Sox (8-10), 11-9 | Metropolitan Stadium (4-6) | 11-10 | |
| » Starters: Bill Monbouquette vs Camilo Pascual | Third | 5 out |
| Tuesday, May 9 |
| » Lost to Orioles (12-10), 13-5 | Metropolitan Stadium (4-7) | 11-11 | Lost 2 |
| » Starters: Chuck Estrada vs Pedro Ramos | Fifth | 5½ out |
| Wednesday, May 10 |
| » Defeated Orioles (12-11), 10-6 | Metropolitan Stadium (5-7) | 12-11 | |
| » Starters: Dick Hall vs Jack Kralick | Third | 5½ out |
| Thursday, May 11 |
| » Lost to Orioles (13-11), 8-7 | Metropolitan Stadium (5-8) | 12-12 | |
| » Starters: Steve Barber vs Camilo Pascual | Fifth | 5½ out |
| Friday, May 12 |
| » Defeated Angels (9-14), 5-4 | Metropolitan Stadium (6-8) | 13-12 | |
| » Starters: Eli Grba vs Pedro Ramos | Fourth | 5½ out |
| Saturday, May 13 |
| » Defeated Angels (9-15), 13-6 | Metropolitan Stadium (7-8) | 14-12 | Won 2 |
| » Starters: Ron Kline vs Don Lee | Fourth | 5½ out |
| Sunday, May 14 |
| » Defeated Angels (9-16), 4-3 | Metropolitan Stadium (8-8) | 15-12 | Won 3 |
| » Starters: Ken McBride vs Jack Kralick | Third | 4 out |
| Monday, May 15 |
| » Defeated White Sox (11-16), 5-0 | Comiskey Park I (1-0) | 16-12 | Won 4 |
| » Starters: Camilo Pascual vs Cal McLish | Third | 4 out |
| Tuesday, May 16 |
| » Lost to White Sox (12-16), 5-4 | Comiskey Park I (1-1) | 16-13 | |
| » Starters: Pedro Ramos vs Early Wynn | Third | 5 out |
| Thursday, May 18 |
| » Lost to Athletics (13-13), 4-3 | Metropolitan Stadium (8-9) | 16-14 | Lost 2 |
| » Starters: Ray Herbert vs Jim Kaat | Third | 5½ out |
| Friday, May 19 |
| » Defeated Athletics (13-14), 11-1 | Metropolitan Stadium (9-9) | 17-14 | |
| » Starters: Ed Rakow vs Jack Kralick | Third | 5 out |
| Saturday, May 20 |
| » Defeated Athletics (13-15), 2-0 | Metropolitan Stadium (10-9) | 18-14 | Won 2 |
| » Starters: Joe Nuxhall vs Camilo Pascual | Second | 4 out |
| Sunday, May 21 |
| » Lost to Indians (19-14), 9-0 | Metropolitan Stadium (10-10) | 18-15 | |
| » Starters: Wynn Hawkins vs Pedro Ramos | Fourth | 5½ out |
| » Lost to Indians (20-14), 2-0 | Metropolitan Stadium (10-11) | 18-16 | Lost 2 |
| » Starters: Mudcat Grant vs Don Lee | Fourth | 5½ out |
| Monday, May 22 |
| » Lost to Indians (21-14), 7-5 | Metropolitan Stadium (10-12) | 18-17 | Lost 3 |
| » Starters: Bobby Locke vs Ed Palmquist | Fourth | 6½ out |
| Tuesday, May 23 |
| » Lost to Tigers (26-11), 5-2 | Metropolitan Stadium (10-13) | 18-18 | Lost 4 |
| » Starters: Jim Bunning vs Jack Kralick | Fifth | 7½ out |
| Wednesday, May 24 |
| » Lost to Tigers (27-11), 5-4 | Metropolitan Stadium (10-14) | 18-19 | Lost 5 |
| » Starters: Don Mossi vs Camilo Pascual | Fifth | 8½ out |
| Thursday, May 25 |
| » Defeated Tigers (27-12), 7-6 | Metropolitan Stadium (11-14) | 19-19 | |
| » Starters: Paul Foytack vs Pedro Ramos | Fifth | 7½ out |
| Friday, May 26 |
| » Lost to Senators (19-22), 4-3 | Griffith Stadium (0-1) | 19-20 | |
| » Starters: Jim Kaat vs Joe McClain | Fifth | 7½ out |
| Saturday, May 27 |
| » Lost to Senators (20-22), 14-4 | Griffith Stadium (0-2) | 19-21 | Lost 2 |
| » Starters: Ed Palmquist vs Hal Woodeshick | Sixth | 7½ out |
| Sunday, May 28 |
| » Lost to Senators (21-22), 6-4 | Griffith Stadium (0-3) | 19-22 | Lost 3 |
| » Starters: Jack Kralick vs Bennie Daniels | Seventh | 8½ out |
| Tuesday, May 30 |
| » Lost to Indians (25-17), 4-3 | Cleveland Stadium (0-1) | 19-23 | Lost 4 |
| » Starters: Camilo Pascual vs Wynn Hawkins | Seventh | 9½ out |
| » Lost to Indians (26-17), 7-5 | Cleveland Stadium (0-2) | 19-24 | Lost 5 |
| » Starters: Pedro Ramos vs Mudcat Grant | Seventh | 9½ out |
| Friday, June 2 |
| » Lost to Tigers (30-16), 2-0 | Tiger Stadium (0-1) | 19-25 | Lost 6 |
| » Starters: Jack Kralick vs Jim Bunning | Eighth | 10 out |
| Saturday, June 3 |
| » Lost to Tigers (31-16), 2-1 | Tiger Stadium (0-2) | 19-26 | Lost 7 |
| » Starters: Pedro Ramos vs Don Mossi | Eighth | 11 out |
| Sunday, June 4 |
| » Lost to Tigers (32-16), 10-4 | Tiger Stadium (0-3) | 19-27 | Lost 8 |
| » Starters: Camilo Pascual vs Frank Lary | Eighth | 13 out |
| » Lost to Tigers (33-16), 9-3 | Tiger Stadium (0-4) | 19-28 | Lost 9 |
| » Starters: Jim Kaat vs Bob Bruce | Eighth | 13 out |
| Monday, June 5 |
| » Lost to Yankees (26-19), 6-2 | Yankee Stadium (1-1) | 19-29 | Lost 10 |
| » Starters: Don Lee vs Jim Coates | Eighth | 13½ out |
| » Lost to Yankees (27-19), 6-1 | Yankee Stadium (1-2) | 19-30 | Lost 11 |
| » Starters: Chuck Stobbs vs Rollie Sheldon | Eighth | 13½ out |
| Tuesday, June 6 |
| » Lost to Yankees (28-19), 7-2 | Yankee Stadium (1-3) | 19-31 | Lost 12 |
| » Manager: Sam Mele |
| » Starters: Jack Kralick vs Whitey Ford | Ninth | 13½ out |
| Wednesday, June 7 |
| » Lost to Yankees (29-19), 5-1 | Yankee Stadium (1-4) | 19-32 | Lost 13 |
| » Starters: Pedro Ramos vs Ralph Terry | Tenth | 14½ out |
| Thursday, June 8 |
| » Defeated Orioles (27-26), 3-1 | Memorial Stadium (4-1) | 20-32 | |
| » Starters: Jim Kaat vs Jack Fisher | Ninth | 14 out |
| Friday, June 9 |
| Future Twin Tom Edens is born in Ontario, OR. |
| Saturday, June 10 |
| » Lost to Orioles (28-26), 4-3 | Memorial Stadium (4-2) | 20-33 | |
| » Starters: Camilo Pascual vs Hal Brown | Ninth | 14½ out |
| Sunday, June 11 |
| » Lost to Red Sox (26-27), 8-2 | Fenway Park (1-1) | 20-34 | Lost 2 |
| » Starters: Pedro Ramos vs Don Schwall | Eighth | 15½ out |
| » Defeated Red Sox (26-28), 10-5 | Fenway Park (2-1) | 21-34 | |
| » Starters: Jack Kralick vs Galen Cisco | Eighth | 15½ out |
| » Major-league debuts: Galen Cisco (Red Sox) |
| Monday, June 12 |
| » Lost to Red Sox (27-28), 10-8 | Fenway Park (2-2) | 21-35 | |
| » Starters: Gerry Arrigo vs Ike Delock | Ninth | 15½ out |
| » Major-league debuts: Jerry Arrigo (Twins) |
| Tuesday, June 13 |
| » Defeated Athletics (24-30), 8-6 | Metropolitan Stadium (12-14) | 22-35 | |
| » Manager: Cookie Lavagetto |
| » Starters: Norm Bass vs Jim Kaat | Ninth | 15½ out |
| Wednesday, June 14 |
| » Lost to Athletics (25-30), 9-2 | Metropolitan Stadium (12-15) | 22-36 | |
| » Starters: Jim Archer vs Camilo Pascual | Eighth | 15½ out |
| Thursday, June 15 |
| » Defeated Athletics (25-31), 4-3 | Metropolitan Stadium (13-15) | 23-36 | |
| » Starters: Joe Nuxhall vs Jack Kralick | Seventh | 14½ out |
| Friday, June 16 |
| » Defeated White Sox (26-34), 6-1 | Comiskey Park I (2-1) | 24-36 | Won 2 |
| » Starters: Danny McDevitt vs Don Larsen | Seventh | 14½ out |
| » Major-league debuts: Rich Rollins (Twins) |
| Saturday, June 17 |
| » Lost to White Sox (27-34), 5-1 | Comiskey Park I (2-2) | 24-37 | |
| » Starters: Jim Kaat vs Juan Pizarro | Ninth | 15½ out |
| Sunday, June 18 |
| » Lost to White Sox (28-34), 4-3 | Comiskey Park I (2-3) | 24-38 | Lost 2 |
| » Starters: Bert Cueto vs Cal McLish | Ninth | 16 out |
| » Lost to White Sox (29-34), 10-7 | Comiskey Park I (2-4) | 24-39 | Lost 3 |
| » Starters: Camilo Pascual vs Ray Herbert | Ninth | 16 out |
| Tuesday, June 20 |
| » Defeated Orioles (32-33), 5-4 | Metropolitan Stadium (14-15) | 25-39 | |
| » Starters: Hal Brown vs Jack Kralick | Ninth | 16 out |
| Wednesday, June 21 |
| » Lost to Orioles (33-33), 11-5 | Metropolitan Stadium (14-16) | 25-40 | |
| » Starters: Chuck Estrada vs Pedro Ramos | Ninth | 16½ out |
| Thursday, June 22 |
| » Lost to Orioles (34-33), 8-2 | Metropolitan Stadium (14-17) | 25-41 | Lost 2 |
| » Starters: Milt Pappas vs Jim Kaat | Ninth | 17½ out |
| Friday, June 23 |
| » Defeated Yankees (41-25), 4-0 | Metropolitan Stadium (15-17) | 26-41 | |
| » Manager: Sam Mele |
| » Starters: Bob Turley vs Camilo Pascual | Ninth | 17½ out |
| Saturday, June 24 |
| » Lost to Yankees (42-25), 10-7 | Metropolitan Stadium (15-18) | 26-42 | |
| » Starters: Rollie Sheldon vs Bert Cueto | Ninth | 18½ out |
| Sunday, June 25 |
| » Lost to Yankees (43-25), 8-4 | Metropolitan Stadium (15-19) | 26-43 | Lost 2 |
| » Starters: Bill Stafford vs Jack Kralick | Eighth | 19 out |
| Tuesday, June 27 |
| » Defeated Red Sox (36-34), 6-5 | Metropolitan Stadium (16-19) | 27-43 | |
| » Starters: Galen Cisco vs Jim Kaat | Eighth | 17 out |
| » Defeated Red Sox (36-35), 6-3 | Metropolitan Stadium (17-19) | 28-43 | Won 2 |
| » Starters: Gene Conley vs Pedro Ramos | Eighth | 17 out |
| Wednesday, June 28 |
| » Lost to Red Sox (37-35), 6-2 | Metropolitan Stadium (17-20) | 28-44 | |
| » Starters: Ike Delock vs Camilo Pascual | Ninth | 18 out |
| Thursday, June 29 |
| » Lost to Red Sox (38-35), 9-5 | Metropolitan Stadium (17-21) | 28-45 | Lost 2 |
| » Starters: Don Schwall vs Bert Cueto | Ninth | 19 out |
| Friday, June 30 |
| » Defeated Athletics (29-43), 8-2 | Municipal Stadium (2-1) | 29-45 | |
| » Starters: Jack Kralick vs Joe Nuxhall | Ninth | 19 out |
| Saturday, July 1 |
| » Defeated Athletics (29-44), 9-3 | Municipal Stadium (3-1) | 30-45 | Won 2 |
| » Starters: Jim Kaat vs Bob Shaw | Eighth | 19 out |
| Sunday, July 2 |
| » Lost to Athletics (30-44), 8-7 | Municipal Stadium (3-2) | 30-46 | |
| » Starters: Pedro Ramos vs Jerry Walker | Ninth | 19 out |
| Monday, July 3 |
| » Defeated White Sox (39-39), 7-6 | Metropolitan Stadium (18-21) | 31-46 | |
| » Starters: Ray Herbert vs Camilo Pascual | Eighth | 18½ out |
| Tuesday, July 4 |
| » Defeated White Sox (39-40), 6-4 | Metropolitan Stadium (19-21) | 32-46 | Won 2 |
| » Starters: Billy Pierce vs Bert Cueto | Eighth | 17½ out |
| » Defeated White Sox (39-41), 4-2 | Metropolitan Stadium (20-21) | 33-46 | Won 3 |
| » Starters: Cal McLish vs Jack Kralick | Eighth | 17½ out |
| Wednesday, July 5 |
| » Lost to Angels (33-48), 6-2 | Metropolitan Stadium (20-22) | 33-47 | |
| » Starters: Eli Grba vs Jim Kaat | Eighth | 18 out |
| Thursday, July 6 |
| » Lost to Angels (34-48), 12-11 | Metropolitan Stadium (20-23) | 33-48 | Lost 2 |
| » Starters: Ryne Duren vs Gerry Arrigo | Ninth | 19 out |
| Friday, July 7 |
| » Lost to Senators (37-45), 3-0 | Griffith Stadium (0-4) | 33-49 | Lost 3 |
| » Starters: Pedro Ramos vs Joe McClain | Eighth | 19½ out |
| Saturday, July 8 |
| » Lost to Senators (38-45), 3-2 | Griffith Stadium (0-5) | 33-50 | Lost 4 |
| » Starters: Jack Kralick vs Ed Hobaugh | Eighth | 20½ out |
| Sunday, July 9 |
| » Defeated Senators (38-46), 7-1 | Griffith Stadium (1-5) | 34-50 | |
| » Starters: Camilo Pascual vs Tom Cheney | Ninth | 20½ out |
| Thursday, July 13 |
| » Defeated Indians (47-40), 9-6 | Cleveland Stadium (1-2) | 35-50 | Won 2 |
| » Starters: Pedro Ramos vs Mudcat Grant | Eighth | 20 out |
| Friday, July 14 |
| » Defeated Tigers (55-31), 5-2 | Tiger Stadium (1-4) | 36-50 | Won 3 |
| » Starters: Jack Kralick vs Frank Lary | Eighth | 19 out |
| Future Twin Vic Rodriguez is born in New York, NY. |
| Saturday, July 15 |
| » Lost to Tigers (56-31), 2-1 | Tiger Stadium (1-5) | 36-51 | |
| » Starters: Camilo Pascual vs Jim Bunning | Eighth | 20 out |
| Sunday, July 16 |
| » Lost to Indians (49-41), 7-5 | Cleveland Stadium (1-3) | 36-52 | Lost 2 |
| » Starters: Jim Kaat vs Gary Bell | Eighth | 21 out |
| » Defeated Indians (49-42), 12-5 | Cleveland Stadium (2-3) | 37-52 | |
| » Starters: Bert Cueto vs Wynn Hawkins | Eighth | 21 out |
| Tuesday, July 18 |
| » Lost to Angels (38-53), 4-1 | Wrigley Field (1-3) | 37-53 | |
| » Starters: Pedro Ramos vs Ken McBride | Ninth | 22 out |
| Wednesday, July 19 |
| » Defeated Angels (38-54), 6-0 | Wrigley Field (2-3) | 38-53 | |
| » Starters: Camilo Pascual vs Eli Grba | Ninth | 21 out |
| » Lost to Angels (39-54), 2-1 | Wrigley Field (2-4) | 38-54 | |
| » Starters: Jack Kralick vs Jim Donohue | Ninth | 21 out |
| Friday, July 21 |
| » Defeated Indians (52-44), 4-3 | Metropolitan Stadium (21-23) | 39-54 | |
| » Starters: Wynn Hawkins vs Don Lee | Ninth | 21 out |
| Saturday, July 22 |
| » Lost to Indians (53-44), 4-0 | Metropolitan Stadium (21-24) | 39-55 | |
| » Starters: Mudcat Grant vs Jim Kaat | Ninth | 22 out |
| Sunday, July 23 |
| » Defeated Indians (53-45), 10-0 | Metropolitan Stadium (22-24) | 40-55 | |
| » Starters: Barry Latman vs Pedro Ramos | Ninth | 21½ out |
| Tuesday, July 25 |
| » Lost to Senators (43-53), 2-1 | Metropolitan Stadium (22-25) | 40-56 | |
| » Starters: Dick Donovan vs Jack Kralick | Ninth | 22½ out |
| Wednesday, July 26 |
| » Defeated Senators (43-54), 10-9 | Metropolitan Stadium (23-25) | 41-56 | |
| » Starters: Bennie Daniels vs Camilo Pascual | Ninth | 22½ out |
| Thursday, July 27 |
| » Defeated Senators (43-55), 5-2 | Metropolitan Stadium (24-25) | 42-56 | Won 2 |
| » Starters: Joe McClain vs Don Lee | Ninth | 22½ out |
| Friday, July 28 |
| » Defeated Tigers (64-36), 4-3 | Tiger Stadium (2-5) | 43-56 | Won 3 |
| » Starters: Pedro Ramos vs Paul Foytack | Ninth | 21½ out |
| Saturday, July 29 |
| » Defeated Tigers (64-37), 5-4 | Tiger Stadium (3-5) | 44-56 | Won 4 |
| » Starters: Jim Kaat vs Jim Bunning | Seventh | 21½ out |
| Sunday, July 30 |
| » Defeated Tigers (64-38), 4-0 | Tiger Stadium (4-5) | 45-56 | Won 5 |
| » Starters: Jack Kralick vs Frank Lary | Seventh | 20 out |
| Wednesday, August 2 |
| » Defeated Orioles (58-47), 4-3 | Memorial Stadium (5-2) | 46-56 | Won 6 |
| » Starters: Don Lee vs Chuck Estrada | Seventh | 21 out |
| » Lost to Orioles (59-47), 4-3 | Memorial Stadium (5-3) | 46-57 | |
| » Starters: Pedro Ramos vs Dick Hall | Seventh | 21 out |
| Thursday, August 3 |
| » Lost to Orioles (60-47), 3-0 | Memorial Stadium (5-4) | 46-58 | Lost 2 |
| » Starters: Jim Kaat vs Hal Brown | Seventh | 21 out |
| Friday, August 4 |
| » Lost to Yankees (68-37), 8-5 | Yankee Stadium (1-5) | 46-59 | Lost 3 |
| » Starters: Camilo Pascual vs Bill Stafford | Eighth | 22 out |
| Saturday, August 5 |
| » Lost to Yankees (69-37), 2-1 | Yankee Stadium (1-6) | 46-60 | Lost 4 |
| » Starters: Jack Kralick vs Jim Coates | Ninth | 23 out |
| Sunday, August 6 |
| » Lost to Yankees (70-37), 7-6 | Yankee Stadium (1-7) | 46-61 | Lost 5 |
| » Starters: Pedro Ramos vs Whitey Ford | Ninth | 25 out |
| » Lost to Yankees (71-37), 3-2 | Yankee Stadium (1-8) | 46-62 | Lost 6 |
| » Starters: Al Schroll vs Rollie Sheldon | Ninth | 25 out |
| Monday, August 7 |
| » Lost to Red Sox (53-60), 5-4 | Fenway Park (2-3) | 46-63 | Lost 7 |
| » Starters: Don Lee vs Ike Delock | Ninth | 26½ out |
| » Lost to Red Sox (54-60), 5-4 | Fenway Park (2-4) | 46-64 | Lost 8 |
| » Starters: Jim Kaat vs Don Schwall | Ninth | 26½ out |
| Tuesday, August 8 |
| » Defeated Red Sox (54-61), 6-5 | Fenway Park (3-4) | 47-64 | |
| » Starters: Camilo Pascual vs Bill Monbouquette | Ninth | 26½ out |
| Wednesday, August 9 |
| » Lost to Red Sox (55-61), 5-4 | Fenway Park (3-5) | 47-65 | |
| » Starters: Jack Kralick vs Gene Conley | Ninth | 27½ out |
| Thursday, August 10 |
| » Lost to Red Sox (56-61), 3-2 | Fenway Park (3-6) | 47-66 | Lost 2 |
| » Starters: Al Schroll vs Tracy Stallard | Ninth | 28½ out |
| Friday, August 11 |
| » Defeated Tigers (72-41), 2-1 | Metropolitan Stadium (25-25) | 48-66 | |
| » Starters: Paul Foytack vs Pedro Ramos | Seventh | 28½ out |
| Saturday, August 12 |
| » Lost to Tigers (73-41), 17-3 | Metropolitan Stadium (25-26) | 48-67 | |
| » Starters: Jim Bunning vs Don Lee | Ninth | 28½ out |
| Sunday, August 13 |
| » Defeated Tigers (73-42), 13-5 | Metropolitan Stadium (26-26) | 49-67 | |
| » Starters: Ron Kline vs Camilo Pascual | Ninth | 28 out |
| Monday, August 14 |
| » Defeated Athletics (42-74), 6-2 | Metropolitan Stadium (27-26) | 50-67 | Won 2 |
| » Starters: Jerry Walker vs Jim Kaat | Eighth | 27½ out |
| Tuesday, August 15 |
| » Defeated Athletics (42-75), 9-4 | Metropolitan Stadium (28-26) | 51-67 | Won 3 |
| » Starters: Jim Archer vs Jack Kralick | Seventh | 26½ out |
| Wednesday, August 16 |
| » Lost to Athletics (43-75), 12-7 | Metropolitan Stadium (28-27) | 51-68 | |
| » Starters: Norm Bass vs Pedro Ramos | Eighth | 27½ out |
| Friday, August 18 |
| » Lost to Angels (52-68), 5-2 | Wrigley Field (2-5) | 51-69 | Lost 2 |
| » Starters: Camilo Pascual vs Eli Grba | Eighth | 28 out |
| Saturday, August 19 |
| » Defeated Angels (52-69), 5-3 | Wrigley Field (3-5) | 52-69 | |
| » Starters: Jim Kaat vs Ted Bowsfield | Seventh | 28 out |
| Sunday, August 20 |
| » Defeated Angels (52-70), 9-7 | Wrigley Field (4-5) | 53-69 | Won 2 |
| » Starters: Jack Kralick vs Jim Donohue | Sixth | 28½ out |
| Tuesday, August 22 |
| » Lost to White Sox (64-60), 4-3 | Comiskey Park I (2-5) | 53-70 | |
| » Starters: Pedro Ramos vs Frank Baumann | Seventh | 28½ out |
| Wednesday, August 23 |
| » Defeated White Sox (64-61), 4-0 | Comiskey Park I (3-5) | 54-70 | |
| » Starters: Camilo Pascual vs Cal McLish | Sixth | 28½ out |
| Thursday, August 24 |
| » Defeated White Sox (64-62), 3-0 | Comiskey Park I (4-5) | 55-70 | Won 2 |
| » Starters: Jim Kaat vs Ray Herbert | Sixth | 27½ out |
| Friday, August 25 |
| » Lost to Orioles (74-55), 5-2 | Metropolitan Stadium (28-28) | 55-71 | |
| » Starters: Jack Fisher vs Jack Kralick | Seventh | 28½ out |
| Saturday, August 26 |
| » Lost to Orioles (75-55), 7-4 | Metropolitan Stadium (28-29) | 55-72 | Lost 2 |
| » Starters: Chuck Estrada vs Al Schroll | Seventh | 29½ out |
| Sunday, August 27 |
| » Lost to Orioles (76-55), 3-0 | Metropolitan Stadium (28-30) | 55-73 | Lost 3 |
| » Starters: Milt Pappas vs Pedro Ramos | Eighth | 30½ out |
| Tuesday, August 29 |
| » Defeated Yankees (86-44), 3-0 | Metropolitan Stadium (29-30) | 56-73 | |
| » Starters: Ralph Terry vs Camilo Pascual | Eighth | 29½ out |
| Wednesday, August 30 |
| » Lost to Yankees (87-44), 4-0 | Metropolitan Stadium (29-31) | 56-74 | |
| » Starters: Bill Stafford vs Jim Kaat | Eighth | 30½ out |
| Thursday, August 31 |
| » Defeated Yankees (87-45), 5-4 | Metropolitan Stadium (30-31) | 57-74 | |
| » Starters: Rollie Sheldon vs Jack Kralick | Seventh | 29½ out |
| Future Twin Mike Hartley is born in Hawthorne, CA. |
| Friday, September 1 |
| » Defeated Red Sox (64-73), 5-1 | Metropolitan Stadium (31-31) | 58-74 | Won 2 |
| » Starters: Don Schwall vs Pedro Ramos | Seventh | 29½ out |
| Saturday, September 2 |
| » Lost to Red Sox (65-73), 2-1 | Metropolitan Stadium (31-32) | 58-75 | |
| » Starters: Bill Monbouquette vs Don Lee | Eighth | 30½ out |
| Sunday, September 3 |
| » Lost to Red Sox (66-73), 8-6 | Metropolitan Stadium (31-33) | 58-76 | Lost 2 |
| » Starters: Tracy Stallard vs Camilo Pascual | Eighth | 31½ out |
| Monday, September 4 |
| » Defeated White Sox (74-65), 9-5 | Metropolitan Stadium (32-33) | 59-76 | |
| » Starters: Frank Baumann vs Al Schroll | Eighth | 32½ out |
| » Lost to White Sox (75-65), 9-5 | Metropolitan Stadium (32-34) | 59-77 | |
| » Starters: Cal McLish vs Jim Kaat | Eighth | 32½ out |
| » Major-league debuts: Joe Horlen (White Sox) |
| Tuesday, September 5 |
| » Tied White Sox, 3-3 | Metropolitan Stadium (32-34) | 59-77 | |
| » Starters: Billy Pierce vs Jack Kralick | Eighth | 33 out |
| » Major-league debuts: Mike Hershberger (White Sox) |
| Wednesday, September 6 |
| » Lost to White Sox (76-65), 6-3 | Metropolitan Stadium (32-35) | 59-78 | Lost 2 |
| » Starters: Juan Pizarro vs Pedro Ramos | Eighth | 34½ out |
| » Lost to White Sox (77-65), 4-2 | Metropolitan Stadium (32-36) | 59-79 | Lost 3 |
| » Starters: Don Larsen vs Camilo Pascual | Eighth | 34½ out |
| Future Twin Roy Smith is born in Mount Vernon, NY. |
| Friday, September 8 |
| » Lost to Athletics (52-88), 6-4 | Municipal Stadium (3-3) | 59-80 | Lost 4 |
| » Starters: Jim Kaat vs Jim Archer | Eighth | 36 out |
| Saturday, September 9 |
| » Defeated Athletics (52-89), 5-4 | Municipal Stadium (4-3) | 60-80 | |
| » Starters: Al Schroll vs Bob Shaw | Eighth | 36 out |
| Sunday, September 10 |
| » Lost to Athletics (53-89), 13-1 | Municipal Stadium (4-4) | 60-81 | |
| » Starters: Jack Kralick vs Norm Bass | Eighth | 37 out |
| » Defeated Athletics (53-90), 7-0 | Municipal Stadium (5-4) | 61-81 | |
| » Starters: Pedro Ramos vs Bill Kunkel | Eighth | 37 out |
| Monday, September 11 |
| » Defeated Angels (63-81), 5-2 | Metropolitan Stadium (33-36) | 62-81 | Won 2 |
| » Starters: Dean Chance vs Camilo Pascual | Eighth | 36½ out |
| » Major-league debuts: Dean Chance (Angels) |
| Thursday, September 14 |
| » Lost to Angels (64-81), 5-1 | Metropolitan Stadium (33-37) | 62-82 | |
| » Starters: Ted Bowsfield vs Don Lee | Eighth | 36 out |
| » Defeated Angels (64-82), 3-1 | Metropolitan Stadium (34-37) | 63-82 | |
| » Starters: Ken McBride vs Jim Kaat | Eighth | 36 out |
| » Major-league debuts: Jim Fregosi (Angels) |
| Friday, September 15 |
| » Defeated Indians (72-75), 3-2 | Cleveland Stadium (3-3) | 64-82 | Won 2 |
| » Starters: Jack Kralick vs Sam McDowell | Eighth | 35½ out |
| » Major-league debuts: Sam McDowell (Indians) Jim Snyder (Twins) |
| Saturday, September 16 |
| » Lost to Indians (73-75), 2-0 | Cleveland Stadium (3-4) | 64-83 | |
| » Starters: Pedro Ramos vs Barry Latman | Eighth | 35½ out |
| » Major-league debuts: Al Luplow (Indians) |
| Future Twin Chris Pittaro is born in Trenton, NJ. |
| Sunday, September 17 |
| » Defeated Indians (73-76), 5-0 | Cleveland Stadium (4-4) | 65-83 | |
| » Starters: Camilo Pascual vs Jim Perry | Seventh | 35 out |
| » Defeated Indians (73-77), 5-3 | Cleveland Stadium (5-4) | 66-83 | Won 2 |
| » Starters: Al Schroll vs Mudcat Grant | Seventh | 35 out |
| Tuesday, September 19 |
| » Defeated Senators (56-95), 3-1 | Griffith Stadium (2-5) | 67-83 | Won 3 |
| » Starters: Jim Kaat vs Joe McClain | Seventh | 34½ out |
| Thursday, September 21 |
| » Defeated Senators (56-96), 6-3 | Griffith Stadium (3-5) | 68-83 | Won 4 |
| » Starters: Jack Kralick vs Bennie Daniels | Seventh | 34 out |
| Saturday, September 23 |
| » Lost to Senators (57-96), 6-4 | Metropolitan Stadium (34-38) | 68-84 | |
| » Starters: Claude Osteen vs Pedro Ramos | Seventh | 34½ out |
| » Defeated Senators (57-97), 10-0 | Metropolitan Stadium (35-38) | 69-84 | |
| » Starters: Pete Burnside vs Camilo Pascual | Seventh | 34½ out |
| Sunday, September 24 |
| » Lost to Senators (58-97), 4-1 | Metropolitan Stadium (35-39) | 69-85 | |
| » Starters: Dick Donovan vs Jim Kaat | Seventh | 34½ out |
| Tuesday, September 26 |
| » Lost to Indians (76-80), 7-3 | Metropolitan Stadium (35-40) | 69-86 | Lost 2 |
| » Starters: Gary Bell vs Jack Kralick | |
