| Sunday, January 8 |
| Former Tiger Schoolboy Rowe dies in ElDorado, AR at the age of 51. |
| Saturday, January 28 |
| Former Tiger Red Oldham dies in Costa Mesa, CA at the age of 68. |
| Wednesday, March 8 |
| Future Tiger Mark Salas is born in Montebello, CA. |
| Friday, March 31 |
| Future Tiger Tracy Jones is born in Hawthorne, CA. |
| Monday, April 3 |
| Future Tiger Doug Baker is born in Fullerton, CA. |
| Tuesday, April 11 |
| » Lost to Indians (1-0), 9-5 | Tiger Stadium (0-1) | 0-1 | |
| » Starters: Jim Perry vs Jim Bunning | Second | 1 out |
| » Major-league debuts: Jim Donohue and Jake Wood (Tigers) |
| Friday, April 14 |
| » Defeated White Sox (1-1), 7-0 | Tiger Stadium (1-1) | 1-1 | |
| » Starters: Frank Baumann vs Frank Lary | Third | 1 out |
| Saturday, April 15 |
| » Defeated White Sox (1-2), 6-2 | Tiger Stadium (2-1) | 2-1 | Won 2 |
| » Starters: Cal McLish vs Don Mossi | First | -- |
| Sunday, April 16 |
| » Major-league debuts: Bill Pleis (Twins) |
| Wednesday, April 19 |
| » Defeated Indians (3-2), 5-2 | Cleveland Stadium (1-0) | 3-1 | Won 3 |
| » Starters: Jim Bunning vs Jim Perry | Second | 1 out |
| » Major-league debuts: Bubba Morton and Mike Roarke (Tigers) |
| Thursday, April 20 |
| » Defeated Indians (3-3), 11-4 | Cleveland Stadium (2-0) | 4-1 | Won 4 |
| » Starters: Frank Lary vs Gary Bell | Second | ½ out |
| » Major-league debuts: Russ Heman (Indians) |
| Friday, April 21 |
| » Defeated Angels (1-5), 9-1 | Tiger Stadium (3-1) | 5-1 | Won 5 |
| » Starters: Jerry Casale vs Don Mossi | First | -- |
| Sunday, April 23 |
| » Defeated Angels (1-6), 3-1 | Tiger Stadium (4-1) | 6-1 | Won 6 |
| » Starters: Ken McBride vs Bob Bruce | First | -- |
| » Defeated Angels (1-7), 3-2 | Tiger Stadium (5-1) | 7-1 | Won 7 |
| » Starters: Ron Kline vs Jim Bunning | First | -- |
| Monday, April 24 |
| » Defeated Yankees (5-4), 4-3 | Tiger Stadium (6-1) | 8-1 | Won 8 |
| » Starters: Bob Turley vs Frank Lary | First | -- |
| Tuesday, April 25 |
| » Major-league debuts: Fred Bruckbauer (Twins) |
| Wednesday, April 26 |
| » Lost to Yankees (6-4), 13-11 | Tiger Stadium (6-2) | 8-2 | |
| » Starters: Whitey Ford vs Don Mossi | First | -- |
| » Major-league debuts: Joe Grzenda (Tigers) |
| Thursday, April 27 |
| » Lost to Red Sox (6-5), 5-2 | Tiger Stadium (6-3) | 8-3 | Lost 2 |
| » Starters: Ike Delock vs Jim Bunning | Second | ½ out |
| Former Tiger Frank Gibson dies in Austin, TX at the age of 71. |
| Saturday, April 29 |
| » Defeated Red Sox (6-6), 9-5 | Tiger Stadium (7-3) | 9-3 | |
| » Starters: Tom Brewer vs Frank Lary | First | -- |
| Sunday, April 30 |
| » Defeated Orioles (7-8), 8-2 | Tiger Stadium (8-3) | 10-3 | Won 2 |
| » Starters: Steve Barber vs Don Mossi | First | -- |
| » Lost to Orioles (8-8), 4-2 | Tiger Stadium (8-4) | 10-4 | |
| » Starters: Hal Brown vs Paul Foytack | First | -- |
| Tuesday, May 2 |
| » Defeated Senators (5-12), 6-3 | Griffith Stadium (1-0) | 11-4 | |
| » Starters: Jim Bunning vs Tom Sturdivant | First | -- |
| Wednesday, May 3 |
| » Lost to Senators (6-12), 5-4 | Griffith Stadium (1-1) | 11-5 | |
| » Starters: Frank Lary vs Joe McClain | First | -- |
| Thursday, May 4 |
| » Defeated Senators (6-13), 6-0 | Griffith Stadium (2-1) | 12-5 | |
| » Starters: Don Mossi vs Bennie Daniels | First | -- |
| Friday, May 5 |
| » Defeated White Sox (7-10), 8-4 | Comiskey Park I (1-0) | 13-5 | Won 2 |
| » Starters: Paul Foytack vs Bob Shaw | First | -- |
| Saturday, May 6 |
| » Defeated White Sox (7-11), 11-8 | Comiskey Park I (2-0) | 14-5 | Won 3 |
| » Starters: Jim Bunning vs Billy Pierce | First | -- |
| Sunday, May 7 |
| » Defeated White Sox (7-12), 8-6 | Comiskey Park I (3-0) | 15-5 | Won 4 |
| » Starters: Frank Lary vs Early Wynn | First | -- |
| » Defeated White Sox (7-13), 5-3 | Comiskey Park I (4-0) | 16-5 | Won 5 |
| » Starters: Phil Regan vs Cal McLish | First | -- |
| Tuesday, May 9 |
| » Defeated Senators (8-15), 7-2 | Tiger Stadium (9-4) | 17-5 | Won 6 |
| » Starters: Joe McClain vs Don Mossi | First | -- |
| » Lost to Senators (9-15), 5-4 | Tiger Stadium (9-5) | 17-6 | |
| » Starters: Bennie Daniels vs Paul Foytack | First | -- |
| Wednesday, May 10 |
| » Defeated Senators (9-16), 7-1 | Tiger Stadium (10-5) | 18-6 | |
| » Starters: Ed Hobaugh vs Jim Bunning | First | -- |
| Thursday, May 11 |
| » Lost to Senators (10-16), 9-4 | Tiger Stadium (10-6) | 18-7 | |
| » Starters: Gabe Gabler vs Bill Fischer | First | -- |
| Friday, May 12 |
| » Defeated Yankees (14-9), 4-3 | Yankee Stadium (1-0) | 19-7 | |
| » Starters: Frank Lary vs Art Ditmar | First | -- |
| Saturday, May 13 |
| » Defeated Yankees (14-10), 8-3 | Yankee Stadium (2-0) | 20-7 | Won 2 |
| » Starters: Phil Regan vs Bob Turley | First | -- |
| Sunday, May 14 |
| » Lost to Yankees (15-10), 5-4 | Yankee Stadium (2-1) | 20-8 | |
| » Starters: Don Mossi vs Whitey Ford | First | -- |
| » Lost to Yankees (16-10), 8-6 | Yankee Stadium (2-2) | 20-9 | Lost 2 |
| » Starters: Jim Bunning vs Ralph Terry | First | -- |
| Monday, May 15 |
| » Defeated Orioles (15-14), 10-5 | Memorial Stadium (1-0) | 21-9 | |
| » Starters: Paul Foytack vs Dick Hall | First | -- |
| Tuesday, May 16 |
| » Defeated Orioles (15-15), 10-4 | Memorial Stadium (2-0) | 22-9 | Won 2 |
| » Starters: Frank Lary vs Steve Barber | First | -- |
| Wednesday, May 17 |
| » Defeated Orioles (15-16), 9-1 | Memorial Stadium (3-0) | 23-9 | Won 3 |
| » Starters: Phil Regan vs Jack Fisher | First | -- |
| Thursday, May 18 |
| » Lost to Red Sox (12-17), 1-0 | Fenway Park (0-1) | 23-10 | |
| » Starters: Jim Bunning vs Gene Conley | First | -- |
| Saturday, May 20 |
| » Lost to Red Sox (13-17), 4-3 | Fenway Park (0-2) | 23-11 | Lost 2 |
| » Starters: Don Mossi vs Billy Muffett | First | -- |
| Sunday, May 21 |
| » Defeated Athletics (13-16), 5-3 | Municipal Stadium (1-0) | 24-11 | |
| » Starters: Frank Lary vs Bud Daley | First | -- |
| Monday, May 22 |
| » Defeated Athletics (13-17), 10-2 | Municipal Stadium (2-0) | 25-11 | Won 2 |
| » Starters: Phil Regan vs Norm Bass | First | -- |
| Tuesday, May 23 |
| » Defeated Twins (18-18), 5-2 | Metropolitan Stadium (1-0) | 26-11 | Won 3 |
| » Starters: Jim Bunning vs Jack Kralick | First | -- |
| Wednesday, May 24 |
| » Defeated Twins (18-19), 5-4 | Metropolitan Stadium (2-0) | 27-11 | Won 4 |
| » Starters: Don Mossi vs Camilo Pascual | First | -- |
| Thursday, May 25 |
| » Lost to Twins (19-19), 7-6 | Metropolitan Stadium (2-1) | 27-12 | |
| » Starters: Paul Foytack vs Pedro Ramos | First | -- |
| Friday, May 26 |
| » Lost to Angels (14-23), 5-4 | Wrigley Field (0-1) | 27-13 | Lost 2 |
| » Starters: Frank Lary vs Ron Kline | First | -- |
| Saturday, May 27 |
| » Lost to Angels (15-23), 10-1 | Wrigley Field (0-2) | 27-14 | Lost 3 |
| » Starters: Phil Regan vs Ken McBride | First | -- |
| Sunday, May 28 |
| » Defeated Angels (15-24), 9-4 | Wrigley Field (1-2) | 28-14 | |
| » Starters: Jim Bunning vs Art Fowler | First | -- |
| Tuesday, May 30 |
| » Defeated Athletics (17-20), 5-3 | Tiger Stadium (11-6) | 29-14 | Won 2 |
| » Starters: Jim Archer vs Don Mossi | First | -- |
| » Lost to Athletics (18-20), 9-3 | Tiger Stadium (11-7) | 29-15 | |
| » Starters: Jerry Walker vs Paul Foytack | First | -- |
| Wednesday, May 31 |
| » Lost to Athletics (19-20), 6-4 | Tiger Stadium (11-8) | 29-16 | Lost 2 |
| » Starters: Joe Nuxhall vs Frank Lary | First | -- |
| Thursday, June 1 |
| » Tied Athletics, 4-4 | Tiger Stadium (11-8) | 29-16 | |
| » Starters: Ray Herbert vs Phil Regan | First | -- |
| Friday, June 2 |
| » Defeated Twins (19-25), 2-0 | Tiger Stadium (12-8) | 30-16 | |
| » Starters: Jack Kralick vs Jim Bunning | First | -- |
| Saturday, June 3 |
| » Defeated Twins (19-26), 2-1 | Tiger Stadium (13-8) | 31-16 | Won 2 |
| » Starters: Pedro Ramos vs Don Mossi | First | -- |
| Sunday, June 4 |
| » Defeated Twins (19-27), 10-4 | Tiger Stadium (14-8) | 32-16 | Won 3 |
| » Starters: Camilo Pascual vs Frank Lary | First | -- |
| » Defeated Twins (19-28), 9-3 | Tiger Stadium (15-8) | 33-16 | Won 4 |
| » Starters: Jim Kaat vs Bob Bruce | First | -- |
| Monday, June 5 |
| » Lost to White Sox (18-29), 8-0 | Comiskey Park I (4-1) | 33-17 | |
| » Starters: Phil Regan vs Frank Baumann | First | -- |
| Tuesday, June 6 |
| » Lost to White Sox (19-29), 7-1 | Comiskey Park I (4-2) | 33-18 | Lost 2 |
| » Starters: Jim Bunning vs Early Wynn | Second | 1 out |
| Thursday, June 8 |
| » Lost to Indians (34-17), 1-0 | Tiger Stadium (15-9) | 33-19 | Lost 3 |
| » Starters: Jim Perry vs Don Mossi | Second | ½ out |
| » Defeated Indians (34-18), 2-1 | Tiger Stadium (16-9) | 34-19 | |
| » Starters: Wynn Hawkins vs Frank Lary | Second | ½ out |
| Friday, June 9 |
| » Lost to Indians (35-18), 5-4 | Tiger Stadium (16-10) | 34-20 | |
| » Starters: Bobby Locke vs Phil Regan | Second | 1½ out |
| Saturday, June 10 |
| » Defeated Indians (35-19), 2-0 | Tiger Stadium (17-10) | 35-20 | |
| » Starters: Gary Bell vs Jim Bunning | Second | ½ out |
| Sunday, June 11 |
| » Lost to Senators (28-28), 7-4 | Tiger Stadium (17-11) | 35-21 | |
| » Starters: Joe McClain vs Hal Woodeshick | Second | 1½ out |
| » Defeated Senators (28-29), 7-6 | Tiger Stadium (18-11) | 36-21 | |
| » Starters: Tom Sturdivant vs Bob Bruce | Second | 1½ out |
| Tuesday, June 13 |
| » Defeated Red Sox (27-29), 7-1 | Tiger Stadium (19-11) | 37-21 | Won 2 |
| » Starters: Gene Conley vs Don Mossi | Second | 1 out |
| Wednesday, June 14 |
| » Defeated Red Sox (27-30), 4-2 | Tiger Stadium (20-11) | 38-21 | Won 3 |
| » Starters: Billy Muffett vs Frank Lary | First | -- |
| Thursday, June 15 |
| » Lost to Red Sox (28-30), 10-1 | Tiger Stadium (20-12) | 38-22 | |
| » Starters: Bill Monbouquette vs Jim Bunning | Second | 1 out |
| Friday, June 16 |
| » Defeated Yankees (37-22), 4-2 | Tiger Stadium (21-12) | 39-22 | |
| » Starters: Bill Stafford vs Phil Regan | First | -- |
| Saturday, June 17 |
| » Defeated Yankees (37-23), 12-10 | Tiger Stadium (22-12) | 40-22 | Won 2 |
| » Starters: Bud Daley vs Don Mossi | First | -- |
| Sunday, June 18 |
| » Lost to Yankees (38-23), 9-0 | Tiger Stadium (22-13) | 40-23 | |
| » Starters: Whitey Ford vs Frank Lary | First | -- |
| Tuesday, June 20 |
| » Defeated Senators (30-35), 5-4 | Griffith Stadium (3-1) | 41-23 | |
| » Starters: Jim Bunning vs Dick Donovan | First | -- |
| Thursday, June 22 |
| » Defeated Senators (30-36), 6-4 | Griffith Stadium (4-1) | 42-23 | Won 2 |
| » Starters: Phil Regan vs Ed Hobaugh | First | -- |
| Friday, June 23 |
| » Defeated Indians (40-28), 15-7 | Cleveland Stadium (3-0) | 43-23 | Won 3 |
| » Starters: Don Mossi vs Jim Perry | First | -- |
| Saturday, June 24 |
| » Defeated Indians (40-29), 5-4 | Cleveland Stadium (4-0) | 44-23 | Won 4 |
| » Starters: Frank Lary vs Mudcat Grant | First | -- |
| Sunday, June 25 |
| » Defeated Indians (40-30), 6-3 | Cleveland Stadium (5-0) | 45-23 | Won 5 |
| » Starters: Jim Bunning vs Wynn Hawkins | First | -- |
| » Lost to Indians (41-30), 4-3 | Cleveland Stadium (5-1) | 45-24 | |
| » Starters: Bob Bruce vs Gary Bell | First | -- |
| Tuesday, June 27 |
| » Lost to White Sox (37-34), 6-5 | Tiger Stadium (22-14) | 45-25 | Lost 2 |
| » Starters: Frank Baumann vs Jerry Casale | First | -- |
| » Lost to White Sox (38-34), 11-1 | Tiger Stadium (22-15) | 45-26 | Lost 3 |
| » Starters: Juan Pizarro vs Phil Regan | First | -- |
| Wednesday, June 28 |
| » Defeated White Sox (38-35), 12-5 | Tiger Stadium (23-15) | 46-26 | |
| » Starters: Ray Herbert vs Don Mossi | First | -- |
| Thursday, June 29 |
| » Defeated White Sox (38-36), 5-2 | Tiger Stadium (24-15) | 47-26 | Won 2 |
| » Starters: Cal McLish vs Frank Lary | First | -- |
| Friday, June 30 |
| » Defeated Orioles (40-35), 6-5 | Memorial Stadium (4-0) | 48-26 | Won 3 |
| » Starters: Jim Bunning vs Jack Fisher | First | -- |
| Saturday, July 1 |
| » Defeated Orioles (40-36), 11-8 | Memorial Stadium (5-0) | 49-26 | Won 4 |
| » Starters: Bob Bruce vs Hal Brown | First | -- |
| » Major-league debuts: Fred Gladding (Tigers) |
| Sunday, July 2 |
| » Lost to Orioles (41-36), 6-3 | Memorial Stadium (5-1) | 49-27 | |
| » Starters: Phil Regan vs Chuck Estrada | First | -- |
| Tuesday, July 4 |
| » Lost to Yankees (48-27), 6-2 | Yankee Stadium (2-3) | 49-28 | Lost 2 |
| » Starters: Don Mossi vs Whitey Ford | First | -- |
| » Defeated Yankees (48-28), 4-3 | Yankee Stadium (3-3) | 50-28 | |
| » Starters: Frank Lary vs Bob Turley | First | -- |
| Wednesday, July 5 |
| » Defeated Red Sox (38-41), 6-2 | Fenway Park (1-2) | 51-28 | Won 2 |
| » Starters: Jim Bunning vs Billy Muffett | First | -- |
| » Lost to Red Sox (39-41), 8-3 | Fenway Park (1-3) | 51-29 | |
| » Starters: Bob Bruce vs Bill Monbouquette | First | -- |
| Thursday, July 6 |
| » Defeated Red Sox (39-42), 3-0 | Fenway Park (2-3) | 52-29 | |
| » Starters: Phil Regan vs Galen Cisco | First | -- |
| Friday, July 7 |
| » Lost to Angels (35-48), 4-2 | Tiger Stadium (24-16) | 52-30 | |
| » Starters: Ken McBride vs Hal Woodeshick | Second | 1½ out |
| Saturday, July 8 |
| » Defeated Angels (35-49), 3-2 | Tiger Stadium (25-16) | 53-30 | |
| » Starters: Ted Bowsfield vs Don Mossi | Second | 1½ out |
| Sunday, July 9 |
| » Defeated Angels (35-50), 1-0 | Tiger Stadium (26-16) | 54-30 | Won 2 |
| » Starters: Eli Grba vs Frank Lary | First | -- |
| » Defeated Angels (35-51), 6-3 | Tiger Stadium (27-16) | 55-30 | Won 3 |
| » Starters: Ryne Duren vs Jim Bunning | First | -- |
| Friday, July 14 |
| » Lost to Twins (36-50), 5-2 | Tiger Stadium (27-17) | 55-31 | |
| » Starters: Jack Kralick vs Frank Lary | Second | 1 out |
| Saturday, July 15 |
| » Defeated Twins (36-51), 2-1 | Tiger Stadium (28-17) | 56-31 | |
| » Starters: Camilo Pascual vs Jim Bunning | Second | 1 out |
| Sunday, July 16 |
| » Defeated Athletics (33-54), 11-1 | Tiger Stadium (29-17) | 57-31 | Won 2 |
| » Starters: Jim Archer vs Don Mossi | First | -- |
| » Defeated Athletics (33-55), 8-3 | Tiger Stadium (30-17) | 58-31 | Won 3 |
| » Starters: Jerry Walker vs Phil Regan | First | -- |
| Monday, July 17 |
| » Defeated Athletics (33-56), 7-4 | Tiger Stadium (31-17) | 59-31 | Won 4 |
| » Starters: Joe Nuxhall vs Paul Foytack | First | -- |
| Former Tiger Ty Cobb dies in Atlanta, GA at the age of 75. |
| Tuesday, July 18 |
| » Lost to Orioles (50-41), 8-7 | Tiger Stadium (31-18) | 59-32 | |
| » Starters: Chuck Estrada vs Frank Lary | Second | 1½ out |
| Wednesday, July 19 |
| » Lost to Orioles (51-41), 4-2 | Tiger Stadium (31-19) | 59-33 | Lost 2 |
| » Starters: Jack Fisher vs Jim Bunning | Second | 1 out |
| Thursday, July 20 |
| » Defeated Orioles (51-42), 15-8 | Tiger Stadium (32-19) | 60-33 | |
| » Starters: Steve Barber vs Don Mossi | First | -- |
| Friday, July 21 |
| » Lost to Athletics (34-58), 3-2 | Municipal Stadium (2-1) | 60-34 | |
| » Starters: Phil Regan vs Jim Archer | Second | 1½ out |
| Sunday, July 23 |
| » Defeated Athletics (34-59), 6-4 | Municipal Stadium (3-1) | 61-34 | |
| » Starters: Paul Foytack vs Bob Shaw | First | -- |
| » Defeated Athletics (34-60), 17-14 | Municipal Stadium (4-1) | 62-34 | Won 2 |
| » Starters: Frank Lary vs Ed Rakow | First | -- |
| Monday, July 24 |
| » Defeated Angels (42-55), 5-2 | Wrigley Field (2-2) | 63-34 | Won 3 |
| » Starters: Jim Bunning vs Jim Donohue | First | -- |
| Tuesday, July 25 |
| » Lost to Angels (43-55), 5-4 | Wrigley Field (2-3) | 63-35 | |
| » Starters: Don Mossi vs Ken McBride | Second | 1½ out |
| Wednesday, July 26 |
| » Defeated Angels (43-56), 5-4 | Wrigley Field (3-3) | 64-35 | |
| » Starters: Frank Lary vs Ron Moeller | Second | 1½ out |
| Friday, July 28 |
| » Lost to Twins (43-56), 4-3 | Tiger Stadium (32-20) | 64-36 | |
| » Starters: Pedro Ramos vs Paul Foytack | Second | 1 out |
| Saturday, July 29 |
| » Lost to Twins (44-56), 5-4 | Tiger Stadium (32-21) | 64-37 | Lost 2 |
| » Starters: Jim Kaat vs Jim Bunning | Second | 2 out |
| Sunday, July 30 |
| » Lost to Twins (45-56), 4-0 | Tiger Stadium (32-22) | 64-38 | Lost 3 |
| » Starters: Jack Kralick vs Frank Lary | Second | 1½ out |
| Wednesday, August 2 |
| » Defeated Senators (45-57), 4-3 | Tiger Stadium (33-22) | 65-38 | |
| » Starters: Marty Kutyna vs Don Mossi | Second | 2½ out |
| » Lost to Senators (46-57), 6-2 | Tiger Stadium (33-23) | 65-39 | |
| » Starters: Joe McClain vs Paul Foytack | Second | 2½ out |
| Thursday, August 3 |
| » Defeated Senators (46-58), 2-1 | Tiger Stadium (34-23) | 66-39 | |
| » Starters: Bennie Daniels vs Jim Bunning | Second | 1½ out |
| Friday, August 4 |
| » Defeated Indians (56-52), 6-1 | Tiger Stadium (35-23) | 67-39 | Won 2 |
| » Starters: Barry Latman vs Frank Lary | Second | 1½ out |
| Saturday, August 5 |
| » Defeated Indians (56-53), 7-6 | Tiger Stadium (36-23) | 68-39 | Won 3 |
| » Starters: Gary Bell vs Phil Regan | Second | 1½ out |
| Sunday, August 6 |
| » Defeated Indians (56-54), 2-1 | Tiger Stadium (37-23) | 69-39 | Won 4 |
| » Starters: Jim Perry vs Don Mossi | Second | 2½ out |
| » Lost to Indians (57-54), 9-5 | Tiger Stadium (37-24) | 69-40 | |
| » Starters: Mudcat Grant vs Paul Foytack | Second | 2½ out |
| Tuesday, August 8 |
| » Defeated White Sox (56-55), 3-0 | Comiskey Park I (5-2) | 70-40 | |
| » Starters: Jim Bunning vs Frank Baumann | Second | 3 out |
| Wednesday, August 9 |
| » Defeated White Sox (56-56), 8-2 | Comiskey Park I (6-2) | 71-40 | Won 2 |
| » Starters: Frank Lary vs Cal McLish | Second | 3 out |
| Thursday, August 10 |
| » Defeated White Sox (56-57), 3-2 | Comiskey Park I (7-2) | 72-40 | Won 3 |
| » Starters: Don Mossi vs Juan Pizarro | Second | 3 out |
| Friday, August 11 |
| » Lost to Twins (48-66), 2-1 | Metropolitan Stadium (2-2) | 72-41 | |
| » Starters: Paul Foytack vs Pedro Ramos | Second | 4 out |
| Saturday, August 12 |
| » Defeated Twins (48-67), 17-3 | Metropolitan Stadium (3-2) | 73-41 | |
| » Starters: Jim Bunning vs Don Lee | Second | 3 out |
| Sunday, August 13 |
| » Lost to Twins (49-67), 13-5 | Metropolitan Stadium (3-3) | 73-42 | |
| » Starters: Ron Kline vs Camilo Pascual | Second | 3½ out |
| Tuesday, August 15 |
| » Defeated Orioles (67-52), 2-0 | Tiger Stadium (38-24) | 74-42 | |
| » Starters: Chuck Estrada vs Frank Lary | Second | 2 out |
| » Defeated Orioles (67-53), 3-2 | Tiger Stadium (39-24) | 75-42 | Won 2 |
| » Starters: Hal Brown vs Don Mossi | Second | 2 out |
| Future Tiger Chris Brown is born in Jackson, MS. |
| Wednesday, August 16 |
| » Lost to Orioles (68-53), 8-2 | Tiger Stadium (39-25) | 75-43 | |
| » Starters: Milt Pappas vs Jim Bunning | Second | 3 out |
| Thursday, August 17 |
| » Lost to Orioles (69-53), 3-1 | Tiger Stadium (39-26) | 75-44 | Lost 2 |
| » Starters: Jack Fisher vs Paul Foytack | Second | 4 out |
| Friday, August 18 |
| » Defeated Red Sox (57-67), 5-0 | Tiger Stadium (40-26) | 76-44 | |
| » Starters: Bill Monbouquette vs Ron Kline | Second | 3 out |
| Saturday, August 19 |
| » Defeated Red Sox (57-68), 3-2 | Tiger Stadium (41-26) | 77-44 | Won 2 |
| » Starters: Dave Hillman vs Don Mossi | Second | 3 out |
| Sunday, August 20 |
| » Defeated Red Sox (57-69), 6-1 | Tiger Stadium (42-26) | 78-44 | Won 3 |
| » Starters: Gene Conley vs Frank Lary | Second | 3 out |
| » Defeated Red Sox (57-70), 7-6 | Tiger Stadium (43-26) | 79-44 | Won 4 |
| » Starters: Tracy Stallard vs Jim Bunning | Second | 3 out |
| Tuesday, August 22 |
| » Defeated Indians (63-61), 8-1 | Cleveland Stadium (6-1) | 80-44 | Won 5 |
| » Starters: Paul Foytack vs Mudcat Grant | Second | 2 out |
| Wednesday, August 23 |
| » Lost to Indians (64-61), 4-2 | Cleveland Stadium (6-2) | 80-45 | |
| » Starters: Don Mossi vs Barry Latman | Second | 3 out |
| Thursday, August 24 |
| » Defeated Indians (64-62), 6-0 | Cleveland Stadium (7-2) | 81-45 | |
| » Starters: Frank Lary vs Jim Perry | Second | 2 out |
| Friday, August 25 |
| » Defeated Senators (50-74), 6-0 | Griffith Stadium (5-1) | 82-45 | Won 2 |
| » Starters: Jim Bunning vs Gabe Gabler | Second | 2 out |
| Sunday, August 27 |
| » Defeated Senators (50-75), 7-4 | Griffith Stadium (6-1) | 83-45 | Won 3 |
| » Starters: Don Mossi vs Bennie Daniels | Second | 2 out |
| » Defeated Senators (50-76), 10-1 | Griffith Stadium (7-1) | 84-45 | Won 4 |
| » Starters: Paul Foytack vs Dave Sisler | Second | 2 out |
| Monday, August 28 |
| » Defeated Senators (50-77), 7-3 | Griffith Stadium (8-1) | 85-45 | Won 5 |
| » Starters: Ron Kline vs Joe McClain | Second | 1½ out |
| Tuesday, August 29 |
| » Lost to White Sox (69-62), 4-3 | Tiger Stadium (43-27) | 85-46 | |
| » Starters: Ray Herbert vs Frank Lary | Second | 1½ out |
| Wednesday, August 30 |
| » Lost to White Sox (70-62), 7-4 | Tiger Stadium (43-28) | 85-47 | Lost 2 |
| » Starters: Juan Pizarro vs Jim Bunning | Second | 2½ out |
| Thursday, August 31 |
| » Defeated White Sox (70-63), 8-2 | Tiger Stadium (44-28) | 86-47 | |
| » Starters: Frank Baumann vs Paul Foytack | Second | 1½ out |
| Friday, September 1 |
| » Lost to Yankees (88-45), 1-0 | Yankee Stadium (3-4) | 86-48 | |
| » Starters: Don Mossi vs Whitey Ford | Second | 2½ out |
| Saturday, September 2 |
| » Lost to Yankees (89-45), 7-2 | Yankee Stadium (3-5) | 86-49 | Lost 2 |
| » Starters: Frank Lary vs Ralph Terry | Second | 3½ out |
| Sunday, September 3 |
| » Lost to Yankees (90-45), 8-5 | Yankee Stadium (3-6) | 86-50 | Lost 3 |
| » Starters: Jim Bunning vs Bill Stafford | Second | 4½ out |
| » Major-league debuts: Tom Tresh (Yankees) |
| Monday, September 4 |
| » Game at Memorial Stadium interrupted in the 9th inning with the score of Orioles 4, Tigers 1. Completed on September 05. |
| » Game at Memorial Stadium interrupted in the 9th inning with the score of Orioles 4, Tigers 1. Completed on September 05. |
| » Major-league debuts: Ron Nischwitz (Tigers) |
| Tuesday, September 5 |
| » Lost to Orioles (81-59), 1-0 | Memorial Stadium (5-2) | 86-51 | Lost 4 |
| » Starters: Don Mossi vs Chuck Estrada | Second | 7½ out |
| » Lost to Orioles (82-59), 6-3 | Memorial Stadium (5-3) | 86-52 | Lost 5 |
| » Starters: Paul Foytack vs Jack Fisher | Second | 7½ out |
| » Lost to Orioles (83-59), 4-1 | Memorial Stadium (5-4) | 86-53 | Lost 6 |
| » Starters: Ron Kline vs Billy Hoeft | Second | 7½ out |
| Thursday, September 7 |
| » Lost to Red Sox (68-75), 8-4 | Fenway Park (2-4) | 86-54 | Lost 7 |
| » Starters: Frank Lary vs Bill Monbouquette | Second | 9 out |
| Friday, September 8 |
| » Lost to Red Sox (69-75), 9-2 | Fenway Park (2-5) | 86-55 | Lost 8 |
| » Starters: Jim Bunning vs Tracy Stallard | Second | 10 out |
| » Major-league debuts: Howie Koplitz (Tigers) |
| Saturday, September 9 |
| » Defeated Red Sox (69-76), 3-1 | Fenway Park (3-5) | 87-55 | |
| » Starters: Ron Kline vs Ike Delock | Second | 10 out |
| Sunday, September 10 |
| » Lost to Red Sox (70-76), 8-7 | Fenway Park (3-6) | 87-56 | |
| » Starters: Don Mossi vs Gene Conley | Second | 11½ out |
| Tuesday, September 12 |
| » Defeated Athletics (53-91), 3-1 | Tiger Stadium (45-28) | 88-56 | |
| » Starters: Jerry Walker vs Frank Lary | Second | 11½ out |
| Wednesday, September 13 |
| » Defeated Athletics (53-92), 8-0 | Tiger Stadium (46-28) | 89-56 | Won 2 |
| » Starters: Jim Archer vs Jim Bunning | Second | 11 out |
| Thursday, September 14 |
| » Lost to Athletics (54-92), 5-2 | Tiger Stadium (46-29) | 89-57 | |
| » Starters: Bob Shaw vs Paul Foytack | Second | 10½ out |
| Friday, September 15 |
| » Lost to Yankees (101-47), 11-1 | Tiger Stadium (46-30) | 89-58 | Lost 2 |
| » Starters: Whitey Ford vs Don Mossi | Second | 10½ out |
| » Defeated Yankees (101-48), 4-2 | Tiger Stadium (47-30) | 90-58 | |
| » Starters: Bud Daley vs Ron Kline | Second | 10½ out |
| Saturday, September 16 |
| » Defeated Yankees (101-49), 10-4 | Tiger Stadium (48-30) | 91-58 | Won 2 |
| » Starters: Ralph Terry vs Frank Lary | Second | 9½ out |
| Future Tiger Chris Pittaro is born in Trenton, NJ. |
| Sunday, September 17 |
| » Lost to Yankees (102-49), 6-4 | Tiger Stadium (48-31) | 91-59 | |
| » Starters: Bill Stafford vs Jim Bunning | Second | 10½ out |
| Tuesday, September 19 |
| » Defeated Angels (66-85), 6-2 | Tiger Stadium (49-31) | 92-59 | |
| » Starters: Ken McBride vs Don Mossi | Second | 10 out |
| Wednesday, September 20 |
| » Defeated Angels (66-86), 6-3 | Tiger Stadium (50-31) | 93-59 | Won 2 |
| » Starters: Ted Bowsfield vs Ron Kline | Second | 10 out |
| Friday, September 22 |
| » Defeated Angels (66-87), 6-4 | Wrigley Field (4-3) | 94-59 | Won 3 |
| » Starters: Frank Lary vs Eli Grba | Second | 9 out |
| Future Tiger Vince Coleman is born in Jacksonville, FL. |
| Saturday, September 23 |
| » Defeated Angels (66-88), 4-2 | Wrigley Field (5-3) | 95-59 | Won 4 |
| » Starters: Jim Bunning vs Ken McBride | Second | 9 out |
| Sunday, September 24 |
| » Defeated Angels (66-89), 7-5 | Wrigley Field (6-3) | 96-59 | Won 5 |
| » Starters: Paul Foytack vs Dean Chance | Second | 8 out |
| Monday, September 25 |
| » Defeated Athletics (58-97), 6-4 | Municipal Stadium (5-1) | 97-59 | Won 6 |
| » Starters: Don Mossi vs Jim Archer | Second | 8 out |
| » Lost to Athletics (59-97), 6-3 | Municipal Stadium (5-2) | 97-60 | |
| » Starters: Ron Kline vs Bob Shaw | Second | 8 out |
| Tuesday, September 26 |
| » Lost to Athletics (60-97), 8-5 | Municipal Stadium (5-3) | 97-61 | Lost 2 |
| » Starters: Ron Nischwitz vs Norm Bass | Second | 9 out |
| » Major-league debuts: Bill Freehan (Tigers) |
| Wednesday, September 27 |
| » Defeated Athletics (60-98), 10-2 | Municipal Stadium (6-3) | 98-61 | |
| » Starters: Frank Lary vs Jerry Walker | Second | 8 out |
| Friday, September 29 |
| » Defeated Twins (70-88), 6-4 | Metropolitan Stadium (4-3) | 99-61 | Won 2 |
| » Starters: Jim Bunning vs Camilo Pascual | Second | 8 out |
| Saturday, September 30 |
| » Defeated Twins (70-89), 6-4 | Metropolitan Stadium (5-3) | 100-61 | Won 3 |
| » Starters: Howie Koplitz vs Jim Kaat | Second | 8 out |
| Sunday, October 1 |
| » Defeated Twins (70-90), 8-3 | Metropolitan Stadium (6-3) | 101-61 | Won 4 |
| » Starters: Paul Foytack vs Al Schroll | Second | 8 out |
| Thursday, October 19 |
| Future Tiger Tim Belcher is born in Mount Gilead, OH. |
| Saturday, October 28 |
| Future Tiger Bob Melvin is born in Palo Alto, CA. |
| Tuesday, November 7 |
| Future Tiger Orlando Mercado is born in Arecibo, P.R. |
| Friday, November 24 |
| Former Tiger John Mohardt dies in LaJolla, CA at the age of 64. |
| Monday, December 11 |
| Future Tiger Mike Henneman is born in St. Charles, MO. |
| Friday, December 22 |
| Future Tiger Andy Allanson is born in Richmond, VA. |
| Tuesday, December 26 |
| Future Tiger Storm Davis is born in Dallas, TX. |
Game information provided by Retrosheet (www.retrosheet.org) |