| Monday, April 10 |
| » Lost to White Sox (1-0), 4-3 | Griffith Stadium (0-1) | 0-1 | |
| » Starters: Early Wynn vs Dick Donovan | Third | 1 out |
| Friday, April 14 |
| » Defeated Indians (1-1), 3-2 | Griffith Stadium (1-1) | 1-1 | |
| » Starters: Gary Bell vs Joe McClain | Third | 1 out |
| » Major-league debuts: Joe McClain (Senators) Bob Allen (Indians) |
| Former Senator Cy Falkenberg dies in San Francisco, CA at the age of 81. |
| Saturday, April 15 |
| » Lost to Indians (2-1), 3-1 | Griffith Stadium (1-2) | 1-2 | |
| » Starters: Mudcat Grant vs Bennie Daniels | Third | 1 out |
| Sunday, April 16 |
| » Lost to Indians (3-1), 3-2 | Griffith Stadium (1-3) | 1-3 | Lost 2 |
| » Starters: Johnny Antonelli vs Dick Donovan | Sixth | 2½ out |
| Wednesday, April 19 |
| » Defeated White Sox (1-3), 7-2 | Comiskey Park I (1-0) | 2-3 | |
| » Starters: Ed Hobaugh vs Billy Pierce | Sixth | 2½ out |
| » Major-league debuts: Ed Hobaugh (Senators) |
| Thursday, April 20 |
| » Lost to White Sox (2-3), 6-1 | Comiskey Park I (1-1) | 2-4 | |
| » Starters: Hal Woodeshick vs Early Wynn | Seventh | 3 out |
| Friday, April 21 |
| » Defeated Twins (5-2), 5-3 | Metropolitan Stadium (1-0) | 3-4 | |
| » Starters: Joe McClain vs Camilo Pascual | Fifth | 2½ out |
| Saturday, April 22 |
| » Lost to Twins (6-2), 5-4 | Metropolitan Stadium (1-1) | 3-5 | |
| » Starters: Bennie Daniels vs Pedro Ramos | Eighth | 3 out |
| Sunday, April 23 |
| » Lost to Twins (7-2), 1-0 | Metropolitan Stadium (1-2) | 3-6 | Lost 2 |
| » Starters: Dick Donovan vs Jack Kralick | Ninth | 4½ out |
| Tuesday, April 25 |
| » Lost to Red Sox (5-4), 6-1 | Fenway Park (0-1) | 3-7 | Lost 3 |
| » Starters: Pete Burnside vs Gene Conley | Eighth | 5½ out |
| Wednesday, April 26 |
| » Defeated Red Sox (5-5), 2-1 | Fenway Park (1-1) | 4-7 | |
| » Starters: Tom Sturdivant vs Bill Monbouquette | Eighth | 4½ out |
| Thursday, April 27 |
| » Lost to Orioles (5-7), 5-0 | Griffith Stadium (1-4) | 4-8 | |
| » Starters: Dick Hall vs Joe McClain | Ninth | 5 out |
| Friday, April 28 |
| » Lost to Orioles (6-7), 4-2 | Griffith Stadium (1-5) | 4-9 | Lost 2 |
| » Starters: Chuck Estrada vs Bennie Daniels | Seventh | 5 out |
| Saturday, April 29 |
| » Lost to Orioles (7-7), 5-0 | Griffith Stadium (1-6) | 4-10 | Lost 3 |
| » Starters: Milt Pappas vs Ed Hobaugh | Seventh | 6 out |
| Sunday, April 30 |
| » Lost to Yankees (9-4), 4-3 | Griffith Stadium (1-7) | 4-11 | Lost 4 |
| » Starters: Whitey Ford vs Dick Donovan | Eighth | 6 out |
| » Defeated Yankees (9-5), 2-1 | Griffith Stadium (2-7) | 5-11 | |
| » Starters: Rollie Sheldon vs Hal Woodeshick | Eighth | 6 out |
| Tuesday, May 2 |
| » Lost to Tigers (11-4), 6-3 | Griffith Stadium (2-8) | 5-12 | |
| » Starters: Jim Bunning vs Tom Sturdivant | Seventh | 7 out |
| Wednesday, May 3 |
| » Defeated Tigers (11-5), 5-4 | Griffith Stadium (3-8) | 6-12 | |
| » Starters: Frank Lary vs Joe McClain | Seventh | 6 out |
| Thursday, May 4 |
| » Lost to Tigers (12-5), 6-0 | Griffith Stadium (3-9) | 6-13 | |
| » Starters: Don Mossi vs Bennie Daniels | Sixth | 7 out |
| Friday, May 5 |
| » Defeated Indians (10-9), 5-2 | Cleveland Stadium (1-0) | 7-13 | |
| » Starters: Ed Hobaugh vs Johnny Antonelli | Sixth | 7 out |
| Sunday, May 7 |
| » Lost to Indians (11-9), 4-2 | Cleveland Stadium (1-1) | 7-14 | |
| » Starters: Tom Sturdivant vs Wynn Hawkins | Seventh | 8½ out |
| » Defeated Indians (11-10), 4-3 | Cleveland Stadium (2-1) | 8-14 | |
| » Starters: Pete Burnside vs Mudcat Grant | Seventh | 8½ out |
| Tuesday, May 9 |
| » Lost to Tigers (17-5), 7-2 | Tiger Stadium (0-1) | 8-15 | |
| » Starters: Joe McClain vs Don Mossi | Ninth | 8½ out |
| » Defeated Tigers (17-6), 5-4 | Tiger Stadium (1-1) | 9-15 | |
| » Starters: Bennie Daniels vs Paul Foytack | Ninth | 8½ out |
| Wednesday, May 10 |
| » Lost to Tigers (18-6), 7-1 | Tiger Stadium (1-2) | 9-16 | |
| » Starters: Ed Hobaugh vs Jim Bunning | Eighth | 9½ out |
| Thursday, May 11 |
| » Defeated Tigers (18-7), 9-4 | Tiger Stadium (2-2) | 10-16 | |
| » Starters: Gabe Gabler vs Bill Fischer | Ninth | 8½ out |
| Friday, May 12 |
| » Lost to Red Sox (10-12), 2-1 | Griffith Stadium (3-10) | 10-17 | |
| » Starters: Bill Monbouquette vs Pete Burnside | Ninth | 9½ out |
| Saturday, May 13 |
| » Defeated Red Sox (10-13), 4-0 | Griffith Stadium (4-10) | 11-17 | |
| » Starters: Gene Conley vs Tom Sturdivant | Ninth | 9½ out |
| Sunday, May 14 |
| » Defeated Red Sox (10-14), 3-0 | Griffith Stadium (5-10) | 12-17 | Won 2 |
| » Starters: Billy Muffett vs Joe McClain | Seventh | 7½ out |
| » Defeated Red Sox (10-15), 2-1 | Griffith Stadium (6-10) | 13-17 | Won 3 |
| » Starters: Chet Nichols vs Bennie Daniels | Seventh | 7½ out |
| » Major-league debuts: Chuck Hinton (Senators) |
| Tuesday, May 16 |
| » Defeated Yankees (16-11), 3-2 | Yankee Stadium (1-0) | 14-17 | Won 4 |
| » Starters: Hal Woodeshick vs Bill Stafford | Seventh | 8 out |
| Wednesday, May 17 |
| » Defeated Yankees (16-12), 8-7 | Yankee Stadium (2-0) | 15-17 | Won 5 |
| » Starters: Pete Burnside vs Art Ditmar | Seventh | 8 out |
| Friday, May 19 |
| » Lost to Orioles (16-16), 4-2 | Memorial Stadium (0-1) | 15-18 | |
| » Starters: Tom Sturdivant vs Billy Hoeft | Sixth | 8 out |
| Saturday, May 20 |
| » Lost to Orioles (17-16), 4-3 | Memorial Stadium (0-2) | 15-19 | Lost 2 |
| » Starters: Joe McClain vs Hal Brown | Sixth | 8 out |
| Sunday, May 21 |
| » Defeated Angels (11-20), 6-2 | Wrigley Field (1-0) | 16-19 | |
| » Starters: Bennie Daniels vs Ron Moeller | Sixth | 7½ out |
| » Defeated Angels (11-21), 7-2 | Wrigley Field (2-0) | 17-19 | Won 2 |
| » Starters: Hal Woodeshick vs Ron Kline | Sixth | 7½ out |
| Monday, May 22 |
| » Lost to Angels (12-21), 6-4 | Wrigley Field (2-1) | 17-20 | |
| » Starters: Pete Burnside vs Eli Grba | Sixth | 8½ out |
| Tuesday, May 23 |
| » Defeated Athletics (13-18), 7-3 | Municipal Stadium (1-0) | 18-20 | |
| » Starters: Ed Hobaugh vs Ray Herbert | Sixth | 8½ out |
| Wednesday, May 24 |
| » Lost to Athletics (14-18), 6-5 | Municipal Stadium (1-1) | 18-21 | |
| » Starters: Tom Sturdivant vs Jim Archer | Sixth | 9½ out |
| Thursday, May 25 |
| » Lost to Athletics (15-18), 4-3 | Municipal Stadium (1-2) | 18-22 | Lost 2 |
| » Starters: Dick Donovan vs Joe Nuxhall | Seventh | 9½ out |
| Friday, May 26 |
| » Defeated Twins (19-20), 4-3 | Griffith Stadium (7-10) | 19-22 | |
| » Starters: Jim Kaat vs Joe McClain | Sixth | 8½ out |
| Saturday, May 27 |
| » Defeated Twins (19-21), 14-4 | Griffith Stadium (8-10) | 20-22 | Won 2 |
| » Starters: Ed Palmquist vs Hal Woodeshick | Fifth | 7½ out |
| Sunday, May 28 |
| » Defeated Twins (19-22), 6-4 | Griffith Stadium (9-10) | 21-22 | Won 3 |
| » Starters: Jack Kralick vs Bennie Daniels | Fifth | 7½ out |
| Tuesday, May 30 |
| » Defeated Angels (15-25), 5-1 | Griffith Stadium (10-10) | 22-22 | Won 4 |
| » Starters: Ned Garver vs Ed Hobaugh | Fifth | 7 out |
| Wednesday, May 31 |
| » Lost to Angels (16-25), 5-3 | Griffith Stadium (10-11) | 22-23 | |
| » Starters: Ron Moeller vs Tom Sturdivant | Fifth | 7 out |
| Thursday, June 1 |
| » Defeated Angels (16-26), 3-2 | Griffith Stadium (11-11) | 23-23 | |
| » Starters: Eli Grba vs Joe McClain | Fifth | 6½ out |
| Friday, June 2 |
| » Defeated Athletics (19-21), 12-4 | Griffith Stadium (12-11) | 24-23 | Won 2 |
| » Starters: Bud Daley vs Dick Donovan | Fifth | 6½ out |
| Saturday, June 3 |
| » Lost to Athletics (20-21), 8-0 | Griffith Stadium (12-12) | 24-24 | |
| » Starters: Norm Bass vs Hal Woodeshick | Fifth | 7½ out |
| Sunday, June 4 |
| » Lost to Athletics (21-21), 8-5 | Griffith Stadium (12-13) | 24-25 | Lost 2 |
| » Starters: Jim Archer vs Ed Hobaugh | Sixth | 9 out |
| Monday, June 5 |
| » Lost to Indians (31-17), 7-5 | Griffith Stadium (12-14) | 24-26 | Lost 3 |
| » Starters: Johnny Antonelli vs Tom Sturdivant | Sixth | 9 out |
| Tuesday, June 6 |
| » Lost to Indians (32-17), 14-3 | Griffith Stadium (12-15) | 24-27 | Lost 4 |
| » Starters: Gary Bell vs Joe McClain | Sixth | 9 out |
| Wednesday, June 7 |
| » Lost to Indians (33-17), 11-0 | Griffith Stadium (12-16) | 24-28 | Lost 5 |
| » Starters: Mudcat Grant vs Pete Burnside | Seventh | 10 out |
| Friday, June 9 |
| » Defeated White Sox (19-30), 1-0 | Griffith Stadium (13-16) | 25-28 | |
| » Starters: Cal McLish vs Dick Donovan | Sixth | 9½ out |
| » Defeated White Sox (19-31), 10-9 | Griffith Stadium (14-16) | 26-28 | Won 2 |
| » Starters: Bob Shaw vs Bennie Daniels | Sixth | 9½ out |
| Saturday, June 10 |
| » Defeated White Sox (19-32), 4-3 | Griffith Stadium (15-16) | 27-28 | Won 3 |
| » Starters: Juan Pizarro vs Ed Hobaugh | Fifth | 8½ out |
| Sunday, June 11 |
| » Defeated Tigers (35-21), 7-4 | Tiger Stadium (3-2) | 28-28 | Won 4 |
| » Starters: Joe McClain vs Hal Woodeshick | Fifth | 9½ out |
| » Lost to Tigers (36-21), 7-6 | Tiger Stadium (3-3) | 28-29 | |
| » Starters: Tom Sturdivant vs Bob Bruce | Fifth | 9½ out |
| Tuesday, June 13 |
| » Lost to Orioles (30-28), 8-7 | Memorial Stadium (0-3) | 28-30 | Lost 2 |
| » Starters: Pete Burnside vs Jack Fisher | Fifth | 10 out |
| Wednesday, June 14 |
| » Defeated Orioles (30-29), 5-1 | Memorial Stadium (1-3) | 29-30 | |
| » Starters: Dick Donovan vs Steve Barber | Fourth | 9 out |
| Thursday, June 15 |
| » Defeated Orioles (30-30), 5-2 | Memorial Stadium (2-3) | 30-30 | Won 2 |
| » Starters: Ed Hobaugh vs Hal Brown | Third | 8 out |
| Friday, June 16 |
| » Lost to Red Sox (29-30), 14-9 | Fenway Park (1-2) | 30-31 | |
| » Starters: Tom Sturdivant vs Don Schwall | Fourth | 9 out |
| Saturday, June 17 |
| » Lost to Red Sox (30-30), 6-5 | Fenway Park (1-3) | 30-32 | Lost 2 |
| » Starters: Joe McClain vs Galen Cisco | Sixth | 10 out |
| Sunday, June 18 |
| » Lost to Red Sox (31-30), 13-12 | Fenway Park (1-4) | 30-33 | Lost 3 |
| » Starters: Carl Mathias vs Ike Delock | Sixth | 10½ out |
| » Lost to Red Sox (32-30), 6-5 | Fenway Park (1-5) | 30-34 | Lost 4 |
| » Starters: Pete Burnside vs Gene Conley | Sixth | 10½ out |
| Tuesday, June 20 |
| » Lost to Tigers (41-23), 5-4 | Griffith Stadium (15-17) | 30-35 | Lost 5 |
| » Starters: Jim Bunning vs Dick Donovan | Seventh | 11½ out |
| Thursday, June 22 |
| » Lost to Tigers (42-23), 6-4 | Griffith Stadium (15-18) | 30-36 | Lost 6 |
| » Starters: Phil Regan vs Ed Hobaugh | Seventh | 12½ out |
| Friday, June 23 |
| » Lost to White Sox (33-34), 4-3 | Comiskey Park I (1-2) | 30-37 | Lost 7 |
| » Starters: Joe McClain vs Ray Herbert | Seventh | 13½ out |
| Saturday, June 24 |
| » Lost to White Sox (34-34), 12-6 | Comiskey Park I (1-3) | 30-38 | Lost 8 |
| » Starters: Carl Mathias vs Cal McLish | Seventh | 14½ out |
| Sunday, June 25 |
| » Lost to White Sox (35-34), 7-3 | Comiskey Park I (1-4) | 30-39 | Lost 9 |
| » Starters: Dick Donovan vs Billy Pierce | Seventh | 15½ out |
| » Lost to White Sox (36-34), 6-3 | Comiskey Park I (1-5) | 30-40 | Lost 10 |
| » Starters: Johnny Klippstein vs Early Wynn | Seventh | 15½ out |
| Tuesday, June 27 |
| » Defeated Indians (41-31), 8-5 | Cleveland Stadium (3-1) | 31-40 | |
| » Starters: Ed Hobaugh vs Dick Stigman | Sixth | 14 out |
| Wednesday, June 28 |
| » Lost to Indians (42-31), 3-2 | Cleveland Stadium (3-2) | 31-41 | |
| » Starters: Joe McClain vs Jim Perry | Seventh | 14½ out |
| » Defeated Indians (42-32), 5-2 | Cleveland Stadium (4-2) | 32-41 | |
| » Starters: Bennie Daniels vs Mudcat Grant | Seventh | 14½ out |
| Thursday, June 29 |
| » Defeated Indians (42-33), 3-1 | Cleveland Stadium (5-2) | 33-41 | Won 2 |
| » Starters: Gabe Gabler vs Wynn Hawkins | Seventh | 14½ out |
| Friday, June 30 |
| » Lost to Yankees (45-27), 5-1 | Yankee Stadium (2-1) | 33-42 | |
| » Starters: Dick Donovan vs Whitey Ford | Seventh | 15½ out |
| Saturday, July 1 |
| » Lost to Yankees (46-27), 7-6 | Yankee Stadium (2-2) | 33-43 | Lost 2 |
| » Starters: Carl Mathias vs Bill Stafford | Seventh | 16½ out |
| Sunday, July 2 |
| » Lost to Yankees (47-27), 13-4 | Yankee Stadium (2-3) | 33-44 | Lost 3 |
| » Starters: Pete Burnside vs Bud Daley | Seventh | 16½ out |
| Monday, July 3 |
| » Defeated Red Sox (38-39), 6-3 | Griffith Stadium (16-18) | 34-44 | |
| » Starters: Ike Delock vs Ed Hobaugh | Seventh | 16 out |
| » Major-league debuts: Ron Stillwell (Senators) |
| Tuesday, July 4 |
| » Defeated Red Sox (38-40), 7-3 | Griffith Stadium (17-18) | 35-44 | Won 2 |
| » Starters: Don Schwall vs Tom Cheney | Seventh | 15½ out |
| Wednesday, July 5 |
| » Lost to Orioles (44-36), 2-0 | Griffith Stadium (17-19) | 35-45 | |
| » Starters: Dick Hall vs Bennie Daniels | Seventh | 16 out |
| Thursday, July 6 |
| » Defeated Orioles (44-37), 1-0 | Griffith Stadium (18-19) | 36-45 | |
| » Starters: Wes Stock vs Dick Donovan | Seventh | 16 out |
| Friday, July 7 |
| » Defeated Twins (33-49), 3-0 | Griffith Stadium (19-19) | 37-45 | Won 2 |
| » Starters: Pedro Ramos vs Joe McClain | Sixth | 15½ out |
| Saturday, July 8 |
| » Defeated Twins (33-50), 3-2 | Griffith Stadium (20-19) | 38-45 | Won 3 |
| » Starters: Jack Kralick vs Ed Hobaugh | Sixth | 15½ out |
| Sunday, July 9 |
| » Lost to Twins (34-50), 7-1 | Griffith Stadium (20-20) | 38-46 | |
| » Starters: Camilo Pascual vs Tom Cheney | Seventh | 16½ out |
| Friday, July 14 |
| » Lost to Athletics (32-52), 8-3 | Griffith Stadium (20-21) | 38-47 | Lost 2 |
| » Starters: Ed Rakow vs Joe McClain | Seventh | 17 out |
| » Lost to Athletics (33-52), 9-7 | Griffith Stadium (20-22) | 38-48 | Lost 3 |
| » Starters: Bob Shaw vs Bennie Daniels | Seventh | 17 out |
| Saturday, July 15 |
| » Defeated Athletics (33-53), 7-1 | Griffith Stadium (21-22) | 39-48 | |
| » Starters: Lew Krausse vs Dick Donovan | Seventh | 17 out |
| Sunday, July 16 |
| » Lost to Angels (37-52), 11-2 | Griffith Stadium (21-23) | 39-49 | |
| » Starters: Ted Bowsfield vs Ed Hobaugh | Seventh | 18 out |
| » Defeated Angels (37-53), 4-3 | Griffith Stadium (22-23) | 40-49 | |
| » Starters: Ron Moeller vs Tom Cheney | Seventh | 18 out |
| Former Senator Mike Mitchell dies in Phoenix, AZ at the age of 82. |
| Tuesday, July 18 |
| » Lost to Yankees (58-30), 5-3 | Griffith Stadium (22-24) | 40-50 | |
| » Starters: Rollie Sheldon vs Joe McClain | Seventh | 19 out |
| Wednesday, July 19 |
| » Defeated Yankees (58-31), 8-4 | Griffith Stadium (23-24) | 41-50 | |
| » Starters: Bud Daley vs Bennie Daniels | Seventh | 17 out |
| » Defeated Yankees (58-32), 12-2 | Griffith Stadium (24-24) | 42-50 | Won 2 |
| » Starters: Al Downing vs Dick Donovan | Seventh | 17 out |
| » Major-league debuts: Al Downing (Yankees) |
| Friday, July 21 |
| » Lost to Angels (40-54), 16-5 | Wrigley Field (2-2) | 42-51 | |
| » Starters: Ed Hobaugh vs Ron Moeller | Seventh | 18 out |
| Saturday, July 22 |
| » Lost to Angels (41-54), 7-6 | Wrigley Field (2-3) | 42-52 | Lost 2 |
| » Starters: Tom Cheney vs Ken McBride | Seventh | 19 out |
| Sunday, July 23 |
| » Lost to Angels (42-54), 8-3 | Wrigley Field (2-4) | 42-53 | Lost 3 |
| » Starters: Joe McClain vs Ted Bowsfield | Seventh | 19½ out |
| Tuesday, July 25 |
| » Defeated Twins (40-56), 2-1 | Metropolitan Stadium (2-2) | 43-53 | |
| » Starters: Dick Donovan vs Jack Kralick | Seventh | 19½ out |
| Wednesday, July 26 |
| » Lost to Twins (41-56), 10-9 | Metropolitan Stadium (2-3) | 43-54 | |
| » Starters: Bennie Daniels vs Camilo Pascual | Seventh | 20½ out |
| Thursday, July 27 |
| » Lost to Twins (42-56), 5-2 | Metropolitan Stadium (2-4) | 43-55 | Lost 2 |
| » Starters: Joe McClain vs Don Lee | Seventh | 21½ out |
| Friday, July 28 |
| » Defeated Athletics (36-62), 10-6 | Municipal Stadium (2-2) | 44-55 | |
| » Starters: Marty Kutyna vs Ed Rakow | Seventh | 20½ out |
| Saturday, July 29 |
| » Lost to Athletics (37-62), 2-1 | Municipal Stadium (2-3) | 44-56 | |
| » Starters: Gabe Gabler vs Bob Shaw | Seventh | 21½ out |
| Sunday, July 30 |
| » Defeated Athletics (37-63), 4-0 | Municipal Stadium (3-3) | 45-56 | |
| » Starters: Bennie Daniels vs Jerry Walker | Seventh | 20 out |
| Wednesday, August 2 |
| » Lost to Tigers (65-38), 4-3 | Tiger Stadium (3-4) | 45-57 | |
| » Starters: Marty Kutyna vs Don Mossi | Seventh | 21 out |
| » Defeated Tigers (65-39), 6-2 | Tiger Stadium (4-4) | 46-57 | |
| » Starters: Joe McClain vs Paul Foytack | Seventh | 21 out |
| Thursday, August 3 |
| » Lost to Tigers (66-39), 2-1 | Tiger Stadium (4-5) | 46-58 | |
| » Starters: Bennie Daniels vs Jim Bunning | Seventh | 21 out |
| Saturday, August 5 |
| » Lost to White Sox (54-54), 8-3 | Comiskey Park I (1-6) | 46-59 | Lost 2 |
| » Starters: Gabe Gabler vs Juan Pizarro | Seventh | 22½ out |
| Sunday, August 6 |
| » Lost to White Sox (55-54), 5-4 | Comiskey Park I (1-7) | 46-60 | Lost 3 |
| » Starters: Marty Kutyna vs Ray Herbert | Eighth | 24½ out |
| » Lost to White Sox (56-54), 3-2 | Comiskey Park I (1-8) | 46-61 | Lost 4 |
| » Starters: Joe McClain vs Billy Pierce | Eighth | 24½ out |
| Tuesday, August 8 |
| » Lost to Indians (58-54), 6-5 | Cleveland Stadium (5-3) | 46-62 | Lost 5 |
| » Starters: Bennie Daniels vs Barry Latman | Eighth | 26 out |
| Wednesday, August 9 |
| » Lost to Indians (59-54), 3-1 | Cleveland Stadium (5-4) | 46-63 | Lost 6 |
| » Starters: Gabe Gabler vs Gary Bell | Eighth | 27 out |
| Friday, August 11 |
| » Lost to Yankees (76-37), 12-5 | Griffith Stadium (24-25) | 46-64 | Lost 7 |
| » Starters: Ralph Terry vs Joe McClain | Eighth | 28½ out |
| Saturday, August 12 |
| » Defeated Yankees (76-38), 5-1 | Griffith Stadium (25-25) | 47-64 | |
| » Starters: Bill Stafford vs Dick Donovan | Seventh | 27½ out |
| Sunday, August 13 |
| » Defeated Yankees (76-39), 12-2 | Griffith Stadium (26-25) | 48-64 | Won 2 |
| » Starters: Bud Daley vs Bennie Daniels | Eighth | 27½ out |
| » Lost to Yankees (77-39), 9-4 | Griffith Stadium (26-26) | 48-65 | |
| » Starters: Jim Coates vs Marty Kutyna | Eighth | 27½ out |
| Monday, August 14 |
| » Lost to Angels (50-66), 5-1 | Griffith Stadium (26-27) | 48-66 | Lost 2 |
| » Starters: Ted Bowsfield vs Gabe Gabler | Ninth | 28 out |
| Tuesday, August 15 |
| » Lost to Angels (51-66), 8-7 | Griffith Stadium (26-28) | 48-67 | Lost 3 |
| » Starters: Jim Donohue vs Pete Burnside | Eighth | 28 out |
| Wednesday, August 16 |
| » Defeated Angels (51-67), 3-2 | Griffith Stadium (27-28) | 49-67 | |
| » Starters: Ken McBride vs Dick Donovan | Ninth | 28 out |
| Thursday, August 17 |
| » Defeated Angels (51-68), 4-3 | Griffith Stadium (28-28) | 50-67 | Won 2 |
| » Starters: Ryne Duren vs Bennie Daniels | Eighth | 28 out |
| Friday, August 18 |
| » Lost to Orioles (70-53), 3-2 | Griffith Stadium (28-29) | 50-68 | |
| » Starters: Steve Barber vs Joe McClain | Ninth | 28 out |
| Saturday, August 19 |
| » Lost to Orioles (71-53), 5-0 | Griffith Stadium (28-30) | 50-69 | Lost 2 |
| » Starters: Billy Hoeft vs Marty Kutyna | Eighth | 29 out |
| Sunday, August 20 |
| » Lost to Orioles (72-53), 9-3 | Griffith Stadium (28-31) | 50-70 | Lost 3 |
| » Starters: Chuck Estrada vs Dick Donovan | Eighth | 30½ out |
| Tuesday, August 22 |
| » Lost to Red Sox (58-70), 3-2 | Fenway Park (1-6) | 50-71 | Lost 4 |
| » Starters: Bennie Daniels vs Don Schwall | Eighth | 30½ out |
| Wednesday, August 23 |
| » Lost to Red Sox (59-70), 9-4 | Fenway Park (1-7) | 50-72 | Lost 5 |
| » Starters: Joe McClain vs Bill Monbouquette | Eighth | 31½ out |
| Thursday, August 24 |
| » Lost to Red Sox (60-70), 5-4 | Fenway Park (1-8) | 50-73 | Lost 6 |
| » Starters: Dick Donovan vs Ike Delock | Eighth | 31½ out |
| Friday, August 25 |
| » Lost to Tigers (82-45), 6-0 | Griffith Stadium (28-32) | 50-74 | Lost 7 |
| » Starters: Jim Bunning vs Gabe Gabler | Ninth | 32½ out |
| Sunday, August 27 |
| » Lost to Tigers (83-45), 7-4 | Griffith Stadium (28-33) | 50-75 | Lost 8 |
| » Starters: Don Mossi vs Bennie Daniels | Ninth | 34½ out |
| » Lost to Tigers (84-45), 10-1 | Griffith Stadium (28-34) | 50-76 | Lost 9 |
| » Starters: Paul Foytack vs Dave Sisler | Ninth | 34½ out |
| Monday, August 28 |
| » Lost to Tigers (85-45), 7-3 | Griffith Stadium (28-35) | 50-77 | Lost 10 |
| » Starters: Ron Kline vs Joe McClain | Ninth | 35 out |
| Tuesday, August 29 |
| » Lost to Indians (65-66), 6-4 | Griffith Stadium (28-36) | 50-78 | Lost 11 |
| » Starters: Jim Perry vs Dick Donovan | Ninth | 35 out |
| Wednesday, August 30 |
| » Lost to Indians (66-66), 9-0 | Griffith Stadium (28-37) | 50-79 | Lost 12 |
| » Starters: Gary Bell vs Gabe Gabler | Ninth | 36 out |
| Thursday, August 31 |
| » Lost to Indians (67-66), 3-2 | Griffith Stadium (28-38) | 50-80 | Lost 13 |
| » Starters: Mudcat Grant vs Bennie Daniels | Ninth | 36 out |
| Friday, September 1 |
| » Lost to White Sox (71-63), 3-2 | Griffith Stadium (28-39) | 50-81 | Lost 14 |
| » Starters: Cal McLish vs Ed Hobaugh | Ninth | 36½ out |
| » Defeated White Sox (71-64), 5-1 | Griffith Stadium (29-39) | 51-81 | |
| » Starters: Billy Pierce vs Joe McClain | Ninth | 36½ out |
| Saturday, September 2 |
| » Lost to White Sox (72-64), 12-7 | Griffith Stadium (29-40) | 51-82 | |
| » Starters: Don Larsen vs Tom Cheney | Ninth | 37½ out |
| Sunday, September 3 |
| » Lost to White Sox (73-64), 5-4 | Griffith Stadium (29-41) | 51-83 | Lost 2 |
| » Starters: Ray Herbert vs Marty Kutyna | Ninth | 39 out |
| » Lost to White Sox (74-64), 4-1 | Griffith Stadium (29-42) | 51-84 | Lost 3 |
| » Starters: Juan Pizarro vs Gabe Gabler | Ninth | 39 out |
| Monday, September 4 |
| » Lost to Yankees (91-45), 5-3 | Yankee Stadium (2-4) | 51-85 | Lost 4 |
| » Starters: Bennie Daniels vs Rollie Sheldon | Ninth | 41 out |
| » Lost to Yankees (92-45), 3-2 | Yankee Stadium (2-5) | 51-86 | Lost 5 |
| » Starters: Pete Burnside vs Bud Daley | Ninth | 41 out |
| Tuesday, September 5 |
| » Lost to Yankees (93-45), 6-1 | Yankee Stadium (2-6) | 51-87 | Lost 6 |
| » Starters: Joe McClain vs Jim Coates | Ninth | 42 out |
| Wednesday, September 6 |
| » Lost to Yankees (94-45), 8-0 | Yankee Stadium (2-7) | 51-88 | Lost 7 |
| » Starters: Tom Cheney vs Whitey Ford | Ninth | 43 out |
| » Major-league debuts: Ed Brinkman (Senators) |
| Thursday, September 7 |
| » Lost to Orioles (84-59), 6-3 | Memorial Stadium (2-4) | 51-89 | Lost 8 |
| » Starters: Carl Bouldin vs Milt Pappas | Tenth | 44 out |
| Friday, September 8 |
| » Lost to Orioles (85-59), 2-1 | Memorial Stadium (2-5) | 51-90 | Lost 9 |
| » Starters: Pete Burnside vs Steve Barber | Tenth | 45½ out |
| » Lost to Orioles (86-59), 4-2 | Memorial Stadium (2-6) | 51-91 | Lost 10 |
| » Starters: Ed Hobaugh vs Dick Hall | Tenth | 45½ out |
| Saturday, September 9 |
| » Defeated Orioles (86-60), 6-2 | Memorial Stadium (3-6) | 52-91 | |
| » Starters: Bennie Daniels vs Jack Fisher | Tenth | 45½ out |
| » Major-league debuts: Ken Retzer (Senators) |
| Sunday, September 10 |
| » Lost to Orioles (87-60), 3-2 | Memorial Stadium (3-7) | 52-92 | |
| » Starters: Joe McClain vs Chuck Estrada | Tenth | 47 out |
| Monday, September 11 |
| » Lost to Red Sox (71-76), 14-4 | Griffith Stadium (29-43) | 52-93 | Lost 2 |
| » Starters: Don Schwall vs Tom Cheney | Tenth | 47½ out |
| Tuesday, September 12 |
| » Defeated Red Sox (71-77), 5-1 | Griffith Stadium (30-43) | 53-93 | |
| » Starters: Bill Monbouquette vs Pete Burnside | Tenth | 47½ out |
| Wednesday, September 13 |
| » Defeated Red Sox (71-78), 4-2 | Griffith Stadium (31-43) | 54-93 | Won 2 |
| » Starters: Tracy Stallard vs Ed Hobaugh | Ninth | 47 out |
| Friday, September 15 |
| » Defeated Athletics (54-93), 3-1 | Griffith Stadium (32-43) | 55-93 | Won 3 |
| » Starters: Norm Bass vs Bennie Daniels | Ninth | 45½ out |
| Saturday, September 16 |
| » Defeated Athletics (54-94), 3-0 | Griffith Stadium (33-43) | 56-93 | Won 4 |
| » Starters: Jerry Walker vs Pete Burnside | Ninth | 44½ out |
| Sunday, September 17 |
| » Lost to Athletics (55-94), 3-2 | Griffith Stadium (33-44) | 56-94 | |
| » Starters: Lew Krausse vs Hector Maestri | Ninth | 45½ out |
| Tuesday, September 19 |
| » Lost to Twins (67-83), 3-1 | Griffith Stadium (33-45) | 56-95 | Lost 2 |
| » Starters: Jim Kaat vs Joe McClain | Ninth | 46 out |
| Thursday, September 21 |
| » Lost to Twins (68-83), 6-3 | Griffith Stadium (33-46) | 56-96 | Lost 3 |
| » Starters: Jack Kralick vs Bennie Daniels | Tenth | 46½ out |
| Saturday, September 23 |
| » Defeated Twins (68-84), 6-4 | Metropolitan Stadium (3-4) | 57-96 | |
| » Starters: Claude Osteen vs Pedro Ramos | Tenth | 47 out |
| » Lost to Twins (69-84), 10-0 | Metropolitan Stadium (3-5) | 57-97 | |
| » Starters: Pete Burnside vs Camilo Pascual | Tenth | 47 out |
| Sunday, September 24 |
| » Defeated Twins (69-85), 4-1 | Metropolitan Stadium (4-5) | 58-97 | |
| » Starters: Dick Donovan vs Jim Kaat | Tenth | 46 out |
| Tuesday, September 26 |
| » Defeated Angels (66-90), 3-2 | Wrigley Field (3-4) | 59-97 | Won 2 |
| » Starters: Bennie Daniels vs Ted Bowsfield | Tenth | 46 out |
| Wednesday, September 27 |
| » Lost to Angels (67-90), 8-6 | Wrigley Field (3-5) | 59-98 | |
| » Starters: Claude Osteen vs Bob Sprout | Tenth | 46 out |
| » Major-league debuts: Bob Sprout (Angels) |
| Thursday, September 28 |
| » Lost to Angels (68-90), 13-4 | Wrigley Field (3-6) | 59-99 | Lost 2 |
| » Starters: Dick Donovan vs Eli Grba | Tenth | 46½ out |
| Friday, September 29 |
| » Defeated Athletics (60-99), 2-0 | Municipal Stadium (4-3) | 60-99 | |
| » Starters: Pete Burnside vs Jim Archer | Ninth | 46½ out |
| Saturday, September 30 |
| » Defeated Athletics (60-100), 5-4 | Municipal Stadium (5-3) | 61-99 | Won 2 |
| » Starters: Bennie Daniels vs Bob Shaw | Ninth | 46½ out |
| Sunday, October 1 |
| » Lost to Athletics (61-100), 3-2 | Municipal Stadium (5-4) | 61-100 | |
| » Starters: Claude Osteen vs Norm Bass | Ninth | 47½ out |
Game information provided by Retrosheet (www.retrosheet.org) |