| Tuesday, January 3 |
| Future Red Sox John Leister is born in San Antonio, TX. |
| Saturday, February 25 |
| Future Red Sox Dana Kiecker is born in Sleepy Eye, MN. |
| Tuesday, April 11 |
| » Lost to Athletics (1-0), 5-2 | Fenway Park (0-1) | 0-1 | |
| » Starters: Ray Herbert vs Bill Monbouquette | Second | 1 out |
| » Major-league debuts: Chuck Schilling and Carl Yastrzemski (Red Sox) |
| Saturday, April 15 |
| » Defeated Angels (1-1), 3-0 | Fenway Park (1-1) | 1-1 | |
| » Starters: Jerry Casale vs Ike Delock | Second | ½ out |
| Sunday, April 16 |
| » Major-league debuts: Bill Pleis (Twins) |
| Monday, April 17 |
| » Defeated Angels (1-2), 3-2 | Fenway Park (2-1) | 2-1 | Won 2 |
| » Starters: Ken McBride vs Tom Brewer | Third | 1 out |
| Tuesday, April 18 |
| » Lost to Twins (5-1), 3-2 | Fenway Park (2-2) | 2-2 | |
| » Starters: Jim Kaat vs Billy Muffett | Fourth | 2 out |
| Wednesday, April 19 |
| » Major-league debuts: Ed Hobaugh (Senators) |
| Future Red Sox Spike Owen is born in Cleburne, TX. |
| Friday, April 21 |
| » Lost to White Sox (3-3), 3-2 | Comiskey Park I (0-1) | 2-3 | Lost 2 |
| » Starters: Bill Monbouquette vs Cal McLish | Sixth | 2½ out |
| Saturday, April 22 |
| » Defeated White Sox (3-4), 7-6 | Comiskey Park I (1-1) | 3-3 | |
| » Starters: Ike Delock vs Frank Baumann | Fourth | 2 out |
| Sunday, April 23 |
| » Defeated White Sox (3-5), 4-3 | Comiskey Park I (2-1) | 4-3 | Won 2 |
| » Starters: Tom Brewer vs Billy Pierce | Fifth | 3 out |
| » Lost to White Sox (4-5), 7-1 | Comiskey Park I (2-2) | 4-4 | |
| » Starters: Billy Muffett vs Bob Shaw | Fifth | 3 out |
| Former Red Sox Jack Barry dies in Shrewsbury, MA at the age of 74. |
| Tuesday, April 25 |
| » Defeated Senators (3-7), 6-1 | Fenway Park (3-2) | 5-4 | |
| » Starters: Pete Burnside vs Gene Conley | Third | 3 out |
| Wednesday, April 26 |
| » Lost to Senators (4-7), 2-1 | Fenway Park (3-3) | 5-5 | |
| » Starters: Tom Sturdivant vs Bill Monbouquette | Fifth | 3 out |
| Thursday, April 27 |
| » Defeated Tigers (8-3), 5-2 | Tiger Stadium (1-0) | 6-5 | |
| » Starters: Ike Delock vs Jim Bunning | Fourth | 2½ out |
| Saturday, April 29 |
| » Lost to Tigers (9-3), 9-5 | Tiger Stadium (1-1) | 6-6 | |
| » Starters: Tom Brewer vs Frank Lary | Fourth | 3 out |
| Future Red Sox Wes Gardner is born in Benton, AR. |
| Sunday, April 30 |
| » Defeated Indians (7-8), 4-2 | Cleveland Stadium (1-0) | 7-6 | |
| » Starters: Bill Monbouquette vs Gary Bell | Fifth | 3 out |
| » Lost to Indians (8-8), 10-1 | Cleveland Stadium (1-1) | 7-7 | |
| » Starters: Gene Conley vs Wynn Hawkins | Fifth | 3 out |
| Tuesday, May 2 |
| » Lost to Athletics (6-8), 7-4 | Municipal Stadium (0-1) | 7-8 | Lost 2 |
| » Starters: Ike Delock vs Bud Daley | Fifth | 4 out |
| Wednesday, May 3 |
| » Lost to Athletics (7-8), 9-8 | Municipal Stadium (0-2) | 7-9 | Lost 3 |
| » Starters: Billy Muffett vs Ray Herbert | Fifth | 4 out |
| Friday, May 5 |
| » Lost to Twins (11-9), 5-1 | Metropolitan Stadium (0-1) | 7-10 | Lost 4 |
| » Starters: Tom Brewer vs Jack Kralick | Fifth | 5½ out |
| Sunday, May 7 |
| » Defeated Twins (11-10), 11-9 | Metropolitan Stadium (1-1) | 8-10 | |
| » Starters: Bill Monbouquette vs Camilo Pascual | Fifth | 6½ out |
| Monday, May 8 |
| » Lost to Angels (8-12), 6-5 | Wrigley Field (0-1) | 8-11 | |
| » Starters: Gene Conley vs Ken McBride | Fifth | 7 out |
| Tuesday, May 9 |
| » Lost to Angels (9-12), 8-7 | Wrigley Field (0-2) | 8-12 | Lost 2 |
| » Starters: Ike Delock vs Jerry Casale | Seventh | 7½ out |
| Wednesday, May 10 |
| » Defeated Angels (9-13), 3-2 | Wrigley Field (1-2) | 9-12 | |
| » Starters: Tom Brewer vs Ron Moeller | Fifth | 7½ out |
| Friday, May 12 |
| » Defeated Senators (10-17), 2-1 | Griffith Stadium (1-0) | 10-12 | Won 2 |
| » Starters: Bill Monbouquette vs Pete Burnside | Sixth | 7 out |
| Saturday, May 13 |
| » Lost to Senators (11-17), 4-0 | Griffith Stadium (1-1) | 10-13 | |
| » Starters: Gene Conley vs Tom Sturdivant | Sixth | 8 out |
| Sunday, May 14 |
| » Lost to Senators (12-17), 3-0 | Griffith Stadium (1-2) | 10-14 | Lost 2 |
| » Starters: Billy Muffett vs Joe McClain | Ninth | 8 out |
| » Lost to Senators (13-17), 2-1 | Griffith Stadium (1-3) | 10-15 | Lost 3 |
| » Starters: Chet Nichols vs Bennie Daniels | Ninth | 8 out |
| » Major-league debuts: Chuck Hinton (Senators) |
| Monday, May 15 |
| » Lost to Indians (15-13), 13-2 | Fenway Park (3-4) | 10-16 | Lost 4 |
| » Starters: Mudcat Grant vs Tom Brewer | Ninth | 9 out |
| Tuesday, May 16 |
| » Defeated Indians (15-14), 8-7 | Fenway Park (4-4) | 11-16 | |
| » Starters: Wynn Hawkins vs Ike Delock | Ninth | 9 out |
| Wednesday, May 17 |
| » Lost to Indians (16-14), 1-0 | Fenway Park (4-5) | 11-17 | |
| » Starters: Bobby Locke vs Bill Monbouquette | Ninth | 10 out |
| Thursday, May 18 |
| » Defeated Tigers (23-10), 1-0 | Fenway Park (5-5) | 12-17 | |
| » Starters: Jim Bunning vs Gene Conley | Eighth | 9 out |
| Saturday, May 20 |
| » Defeated Tigers (23-11), 4-3 | Fenway Park (6-5) | 13-17 | Won 2 |
| » Starters: Don Mossi vs Billy Muffett | Seventh | 8 out |
| Sunday, May 21 |
| » Lost to White Sox (14-18), 6-5 | Fenway Park (6-6) | 13-18 | |
| » Starters: Early Wynn vs Ike Delock | Eighth | 8½ out |
| » Defeated White Sox (14-19), 4-1 | Fenway Park (7-6) | 14-18 | |
| » Starters: Cal McLish vs Don Schwall | Eighth | 8½ out |
| » Major-league debuts: Don Schwall (Red Sox) |
| Monday, May 22 |
| » Defeated White Sox (14-20), 4-1 | Fenway Park (8-6) | 15-18 | Won 2 |
| » Starters: Frank Baumann vs Bill Monbouquette | Seventh | 8½ out |
| Tuesday, May 23 |
| Future Red Sox Kevin Romine is born in Exeter, NH. |
| Wednesday, May 24 |
| » Lost to Yankees (19-15), 3-2 | Yankee Stadium (0-1) | 15-19 | |
| » Starters: Gene Conley vs Ralph Terry | Seventh | 10 out |
| Thursday, May 25 |
| » Lost to Yankees (20-15), 6-4 | Yankee Stadium (0-2) | 15-20 | Lost 2 |
| » Starters: Billy Muffett vs Whitey Ford | Eighth | 10 out |
| Saturday, May 27 |
| » Lost to Orioles (23-18), 5-4 | Memorial Stadium (0-1) | 15-21 | Lost 3 |
| » Starters: Bill Monbouquette vs Chuck Estrada | Eighth | 9½ out |
| Sunday, May 28 |
| » Defeated Orioles (23-19), 5-0 | Memorial Stadium (1-1) | 16-21 | |
| » Starters: Don Schwall vs Jack Fisher | Eighth | 9½ out |
| Monday, May 29 |
| » Defeated Yankees (21-17), 2-1 | Fenway Park (9-6) | 17-21 | Won 2 |
| » Starters: Whitey Ford vs Ike Delock | Eighth | 9 out |
| Tuesday, May 30 |
| » Lost to Yankees (22-17), 12-3 | Fenway Park (9-7) | 17-22 | |
| » Starters: Ralph Terry vs Gene Conley | Eighth | 9½ out |
| Wednesday, May 31 |
| » Lost to Yankees (23-17), 7-6 | Fenway Park (9-8) | 17-23 | Lost 2 |
| » Starters: Rollie Sheldon vs Tom Brewer | Eighth | 9½ out |
| Thursday, June 1 |
| » Defeated Yankees (23-18), 7-5 | Fenway Park (10-8) | 18-23 | |
| » Starters: Bob Turley vs Bill Monbouquette | Eighth | 9 out |
| Friday, June 2 |
| » Defeated Orioles (25-21), 4-2 | Fenway Park (11-8) | 19-23 | Won 2 |
| » Starters: Billy Hoeft vs Don Schwall | Seventh | 9 out |
| Saturday, June 3 |
| » Lost to Orioles (26-21), 3-1 | Fenway Park (11-9) | 19-24 | |
| » Starters: Jack Fisher vs Ike Delock | Seventh | 10 out |
| Sunday, June 4 |
| » Defeated Orioles (26-22), 6-5 | Fenway Park (12-9) | 20-24 | |
| » Starters: Steve Barber vs Gene Conley | Seventh | 10½ out |
| Monday, June 5 |
| » Defeated Athletics (21-22), 6-2 | Fenway Park (13-9) | 21-24 | Won 2 |
| » Starters: Ray Herbert vs Mike Fornieles | Seventh | 10 out |
| » Lost to Athletics (22-22), 10-6 | Fenway Park (13-10) | 21-25 | |
| » Starters: Joe Nuxhall vs Tom Brewer | Seventh | 10 out |
| Tuesday, June 6 |
| » Defeated Athletics (22-23), 5-3 | Fenway Park (14-10) | 22-25 | |
| » Starters: Jerry Walker vs Bill Monbouquette | Seventh | 9 out |
| Wednesday, June 7 |
| » Defeated Athletics (22-24), 6-2 | Fenway Park (15-10) | 23-25 | Won 2 |
| » Starters: Bud Daley vs Don Schwall | Fifth | 9 out |
| Thursday, June 8 |
| » Defeated Angels (19-32), 6-5 | Fenway Park (16-10) | 24-25 | Won 3 |
| » Starters: Ron Kline vs Ike Delock | Fifth | 8½ out |
| » Tied Angels, 4-4 | Fenway Park (16-10) | 24-25 | |
| » Starters: Johnny James vs Gene Conley | Fifth | 8½ out |
| Friday, June 9 |
| » Defeated Angels (19-33), 5-3 | Fenway Park (17-10) | 25-25 | Won 4 |
| » Starters: Art Fowler vs Billy Muffett | Fifth | 9 out |
| » Lost to Angels (20-33), 5-1 | Fenway Park (17-11) | 25-26 | |
| » Starters: Ryne Duren vs Mike Fornieles | Fifth | 9 out |
| Saturday, June 10 |
| » Lost to Angels (21-33), 10-5 | Fenway Park (17-12) | 25-27 | Lost 2 |
| » Starters: Ron Moeller vs Bill Monbouquette | Sixth | 9 out |
| Sunday, June 11 |
| » Defeated Twins (20-34), 8-2 | Fenway Park (18-12) | 26-27 | |
| » Starters: Pedro Ramos vs Don Schwall | Sixth | 10 out |
| » Lost to Twins (21-34), 10-5 | Fenway Park (18-13) | 26-28 | |
| » Starters: Jack Kralick vs Galen Cisco | Sixth | 10 out |
| » Major-league debuts: Galen Cisco (Red Sox) |
| Monday, June 12 |
| » Defeated Twins (21-35), 10-8 | Fenway Park (19-13) | 27-28 | |
| » Starters: Gerry Arrigo vs Ike Delock | Fifth | 9 out |
| » Major-league debuts: Jerry Arrigo (Twins) |
| Tuesday, June 13 |
| » Lost to Tigers (37-21), 7-1 | Tiger Stadium (1-2) | 27-29 | |
| » Starters: Gene Conley vs Don Mossi | Sixth | 10 out |
| Wednesday, June 14 |
| » Lost to Tigers (38-21), 4-2 | Tiger Stadium (1-3) | 27-30 | Lost 2 |
| » Starters: Billy Muffett vs Frank Lary | Fifth | 10 out |
| Thursday, June 15 |
| » Defeated Tigers (38-22), 10-1 | Tiger Stadium (2-3) | 28-30 | |
| » Starters: Bill Monbouquette vs Jim Bunning | Fourth | 9 out |
| Friday, June 16 |
| » Defeated Senators (30-31), 14-9 | Fenway Park (20-13) | 29-30 | Won 2 |
| » Starters: Tom Sturdivant vs Don Schwall | Third | 9 out |
| Saturday, June 17 |
| » Defeated Senators (30-32), 6-5 | Fenway Park (21-13) | 30-30 | Won 3 |
| » Starters: Joe McClain vs Galen Cisco | Fourth | 9 out |
| Sunday, June 18 |
| » Defeated Senators (30-33), 13-12 | Fenway Park (22-13) | 31-30 | Won 4 |
| » Starters: Carl Mathias vs Ike Delock | Fourth | 7½ out |
| » Defeated Senators (30-34), 6-5 | Fenway Park (23-13) | 32-30 | Won 5 |
| » Starters: Pete Burnside vs Gene Conley | Fourth | 7½ out |
| Future Red Sox Tom McCarthy is born in Lundstahl, W.Germany. |
| Tuesday, June 20 |
| » Defeated Angels (23-43), 11-8 | Wrigley Field (2-2) | 33-30 | Won 6 |
| » Starters: Bill Monbouquette vs Eli Grba | Fourth | 7½ out |
| Wednesday, June 21 |
| » Lost to Angels (24-43), 5-1 | Wrigley Field (2-3) | 33-31 | |
| » Starters: Don Schwall vs Ken McBride | Fourth | 8 out |
| Thursday, June 22 |
| » Defeated Angels (24-44), 3-2 | Wrigley Field (3-3) | 34-31 | |
| » Starters: Galen Cisco vs Ryne Duren | Fourth | 8 out |
| Friday, June 23 |
| » Defeated Athletics (27-37), 5-4 | Municipal Stadium (1-2) | 35-31 | Won 2 |
| » Starters: Gene Conley vs Lew Krausse | Fourth | 8 out |
| Saturday, June 24 |
| » Lost to Athletics (28-37), 9-3 | Municipal Stadium (1-3) | 35-32 | |
| » Starters: Ike Delock vs Jim Archer | Fourth | 9 out |
| Sunday, June 25 |
| » Defeated Athletics (28-38), 7-4 | Municipal Stadium (2-3) | 36-32 | |
| » Starters: Don Schwall vs Joe Nuxhall | Fourth | 9 out |
| » Lost to Athletics (29-38), 3-2 | Municipal Stadium (2-4) | 36-33 | |
| » Starters: Billy Muffett vs Bob Shaw | Fourth | 9 out |
| Tuesday, June 27 |
| » Lost to Twins (27-43), 6-5 | Metropolitan Stadium (1-2) | 36-34 | Lost 2 |
| » Starters: Galen Cisco vs Jim Kaat | Fifth | 9 out |
| » Lost to Twins (28-43), 6-3 | Metropolitan Stadium (1-3) | 36-35 | Lost 3 |
| » Starters: Gene Conley vs Pedro Ramos | Fifth | 9 out |
| Wednesday, June 28 |
| » Defeated Twins (28-44), 6-2 | Metropolitan Stadium (2-3) | 37-35 | |
| » Starters: Ike Delock vs Camilo Pascual | Sixth | 9 out |
| Thursday, June 29 |
| » Defeated Twins (28-45), 9-5 | Metropolitan Stadium (3-3) | 38-35 | Won 2 |
| » Starters: Don Schwall vs Bert Cueto | Fifth | 9 out |
| Friday, June 30 |
| » Lost to Indians (43-33), 10-2 | Fenway Park (23-14) | 38-36 | |
| » Starters: Gary Bell vs Billy Muffett | Fifth | 10 out |
| » Major-league debuts: Wilbur Wood (Red Sox) |
| Saturday, July 1 |
| » Lost to Indians (44-33), 7-3 | Fenway Park (23-15) | 38-37 | Lost 2 |
| » Starters: Barry Latman vs Galen Cisco | Sixth | 11 out |
| Sunday, July 2 |
| » Lost to Indians (45-33), 12-6 | Fenway Park (23-16) | 38-38 | Lost 3 |
| » Starters: Mudcat Grant vs Gene Conley | Sixth | 11 out |
| Monday, July 3 |
| » Lost to Senators (34-44), 6-3 | Griffith Stadium (1-4) | 38-39 | Lost 4 |
| » Starters: Ike Delock vs Ed Hobaugh | Sixth | 11½ out |
| » Major-league debuts: Ron Stillwell (Senators) |
| Tuesday, July 4 |
| » Lost to Senators (35-44), 7-3 | Griffith Stadium (1-5) | 38-40 | Lost 5 |
| » Starters: Don Schwall vs Tom Cheney | Sixth | 12 out |
| Wednesday, July 5 |
| » Lost to Tigers (51-28), 6-2 | Fenway Park (23-17) | 38-41 | Lost 6 |
| » Starters: Jim Bunning vs Billy Muffett | Fifth | 12 out |
| » Defeated Tigers (51-29), 8-3 | Fenway Park (24-17) | 39-41 | |
| » Starters: Bob Bruce vs Bill Monbouquette | Fifth | 12 out |
| Thursday, July 6 |
| » Lost to Tigers (52-29), 3-0 | Fenway Park (24-18) | 39-42 | |
| » Starters: Phil Regan vs Galen Cisco | Sixth | 13 out |
| Friday, July 7 |
| » Lost to Yankees (51-28), 14-3 | Yankee Stadium (0-3) | 39-43 | Lost 2 |
| » Starters: Gene Conley vs Bud Daley | Fifth | 13½ out |
| Saturday, July 8 |
| » Lost to Yankees (52-28), 8-5 | Yankee Stadium (0-4) | 39-44 | Lost 3 |
| » Starters: Ike Delock vs Whitey Ford | Fifth | 14½ out |
| Sunday, July 9 |
| » Lost to Yankees (53-28), 3-0 | Yankee Stadium (0-5) | 39-45 | Lost 4 |
| » Starters: Bill Monbouquette vs Rollie Sheldon | Sixth | 15 out |
| » Defeated Yankees (53-29), 9-6 | Yankee Stadium (1-5) | 40-45 | |
| » Starters: Don Schwall vs Ralph Terry | Sixth | 15 out |
| Thursday, July 13 |
| » Defeated Orioles (48-38), 3-2 | Fenway Park (25-18) | 41-45 | Won 2 |
| » Starters: Milt Pappas vs Don Schwall | Sixth | 14½ out |
| Friday, July 14 |
| » Lost to Orioles (49-38), 7-6 | Fenway Park (25-19) | 41-46 | |
| » Starters: Chuck Estrada vs Bill Monbouquette | Sixth | 14½ out |
| Saturday, July 15 |
| » Defeated Orioles (49-39), 2-1 | Fenway Park (26-19) | 42-46 | |
| » Starters: Dick Hall vs Gene Conley | Sixth | 14½ out |
| Sunday, July 16 |
| » Lost to White Sox (44-46), 4-3 | Comiskey Park I (2-3) | 42-47 | |
| » Starters: Tracy Stallard vs Billy Pierce | Sixth | 15½ out |
| » Defeated White Sox (44-47), 5-3 | Comiskey Park I (3-3) | 43-47 | |
| » Starters: Ike Delock vs Cal McLish | Sixth | 15½ out |
| Monday, July 17 |
| » Lost to White Sox (45-47), 4-1 | Comiskey Park I (3-4) | 43-48 | |
| » Starters: Galen Cisco vs Early Wynn | Sixth | 16½ out |
| Tuesday, July 18 |
| » Defeated Indians (49-43), 9-2 | Cleveland Stadium (2-1) | 44-48 | |
| » Starters: Don Schwall vs Mudcat Grant | Sixth | 16 out |
| Wednesday, July 19 |
| » Lost to Indians (50-43), 4-1 | Cleveland Stadium (2-2) | 44-49 | |
| » Starters: Gene Conley vs Barry Latman | Sixth | 16 out |
| » Lost to Indians (51-43), 9-8 | Cleveland Stadium (2-3) | 44-50 | Lost 2 |
| » Starters: Wilbur Wood vs Jim Perry | Sixth | 16 out |
| Thursday, July 20 |
| » Lost to Indians (52-43), 12-11 | Cleveland Stadium (2-4) | 44-51 | Lost 3 |
| » Starters: Ike Delock vs Gary Bell | Sixth | 17 out |
| Friday, July 21 |
| » Lost to Yankees (59-32), 11-8 | Fenway Park (26-20) | 44-52 | Lost 4 |
| » Starters: Whitey Ford vs Bill Monbouquette | Sixth | 17½ out |
| Saturday, July 22 |
| » Lost to Yankees (60-32), 11-9 | Fenway Park (26-21) | 44-53 | Lost 5 |
| » Starters: Rollie Sheldon vs Tracy Stallard | Sixth | 18½ out |
| Sunday, July 23 |
| » Defeated Yankees (60-33), 5-4 | Fenway Park (27-21) | 45-53 | |
| » Starters: Bud Daley vs Don Schwall | Sixth | 18 out |
| Tuesday, July 25 |
| » Lost to Orioles (52-45), 5-1 | Memorial Stadium (1-2) | 45-54 | |
| » Starters: Ike Delock vs Steve Barber | Sixth | 19 out |
| Wednesday, July 26 |
| » Lost to Orioles (53-45), 5-1 | Memorial Stadium (1-3) | 45-55 | Lost 2 |
| » Starters: Bill Monbouquette vs Billy Hoeft | Sixth | 20½ out |
| » Lost to Orioles (54-45), 9-2 | Memorial Stadium (1-4) | 45-56 | Lost 3 |
| » Starters: Gene Conley vs Jack Fisher | Sixth | 20½ out |
| Thursday, July 27 |
| » Lost to Orioles (55-45), 8-5 | Memorial Stadium (1-5) | 45-57 | Lost 4 |
| » Starters: Tracy Stallard vs Chuck Estrada | Sixth | 21½ out |
| Friday, July 28 |
| » Defeated White Sox (50-52), 8-3 | Fenway Park (28-21) | 46-57 | |
| » Starters: Cal McLish vs Don Schwall | Sixth | 20½ out |
| Sunday, July 30 |
| » Lost to White Sox (51-52), 4-2 | Fenway Park (28-22) | 46-58 | |
| » Starters: Frank Baumann vs Bill Monbouquette | Sixth | 20 out |
| » Defeated White Sox (51-53), 9-8 | Fenway Park (29-22) | 47-58 | |
| » Starters: Juan Pizarro vs Gene Conley | Sixth | 20 out |
| Wednesday, August 2 |
| » Defeated Angels (45-58), 7-2 | Fenway Park (30-22) | 48-58 | Won 2 |
| » Starters: Jim Donohue vs Ike Delock | Sixth | 20 out |
| » Defeated Angels (45-59), 8-7 | Fenway Park (31-22) | 49-58 | Won 3 |
| » Starters: Ron Moeller vs Tracy Stallard | Sixth | 20 out |
| Future Red Sox Danny Sheaffer is born in Jacksonville, FL. |
| Thursday, August 3 |
| » Defeated Angels (45-60), 4-0 | Fenway Park (32-22) | 50-58 | Won 4 |
| » Starters: Ken McBride vs Don Schwall | Sixth | 19 out |
| Friday, August 4 |
| » Lost to Athletics (39-65), 5-0 | Fenway Park (32-23) | 50-59 | |
| » Starters: Norm Bass vs Bill Monbouquette | Sixth | 20 out |
| Saturday, August 5 |
| » Defeated Athletics (39-66), 10-4 | Fenway Park (33-23) | 51-59 | |
| » Starters: Jerry Walker vs Gene Conley | Sixth | 20 out |
| Sunday, August 6 |
| » Defeated Athletics (39-67), 4-2 | Fenway Park (34-23) | 52-59 | Won 2 |
| » Starters: Ed Rakow vs Galen Cisco | Sixth | 21 out |
| » Lost to Athletics (40-67), 1-0 | Fenway Park (34-24) | 52-60 | |
| » Starters: Jim Archer vs Tracy Stallard | Sixth | 21 out |
| Monday, August 7 |
| » Defeated Twins (46-63), 5-4 | Fenway Park (35-24) | 53-60 | |
| » Starters: Don Lee vs Ike Delock | Sixth | 20½ out |
| » Defeated Twins (46-64), 5-4 | Fenway Park (36-24) | 54-60 | Won 2 |
| » Starters: Jim Kaat vs Don Schwall | Sixth | 20½ out |
| Tuesday, August 8 |
| » Lost to Twins (47-64), 6-5 | Fenway Park (36-25) | 54-61 | |
| » Starters: Camilo Pascual vs Bill Monbouquette | Sixth | 21½ out |
| Wednesday, August 9 |
| » Defeated Twins (47-65), 5-4 | Fenway Park (37-25) | 55-61 | |
| » Starters: Jack Kralick vs Gene Conley | Sixth | 21½ out |
| Thursday, August 10 |
| » Defeated Twins (47-66), 3-2 | Fenway Park (38-25) | 56-61 | Won 2 |
| » Starters: Al Schroll vs Tracy Stallard | Sixth | 21½ out |
| Friday, August 11 |
| » Lost to Orioles (65-51), 6-3 | Memorial Stadium (1-6) | 56-62 | |
| » Starters: Chet Nichols vs Billy Hoeft | Sixth | 22½ out |
| Saturday, August 12 |
| » Lost to Orioles (66-51), 8-3 | Memorial Stadium (1-7) | 56-63 | Lost 2 |
| » Starters: Ike Delock vs Dick Hall | Sixth | 22½ out |
| Sunday, August 13 |
| » Lost to Orioles (67-51), 6-5 | Memorial Stadium (1-8) | 56-64 | Lost 3 |
| » Starters: Bill Monbouquette vs Steve Barber | Sixth | 23 out |
| Tuesday, August 15 |
| » Defeated Indians (60-57), 8-0 | Cleveland Stadium (3-4) | 57-64 | |
| » Starters: Gene Conley vs Gary Bell | Fifth | 22 out |
| Wednesday, August 16 |
| » Lost to Indians (61-57), 6-4 | Cleveland Stadium (3-5) | 57-65 | |
| » Starters: Tracy Stallard vs Jim Perry | Sixth | 23 out |
| Thursday, August 17 |
| » Lost to Indians (62-57), 4-3 | Cleveland Stadium (3-6) | 57-66 | Lost 2 |
| » Starters: Ike Delock vs Wynn Hawkins | Sixth | 24 out |
| » Major-league debuts: Bill Dailey (Indians) |
| Friday, August 18 |
| » Lost to Tigers (76-44), 5-0 | Tiger Stadium (2-4) | 57-67 | Lost 3 |
| » Starters: Bill Monbouquette vs Ron Kline | Sixth | 24 out |
| Saturday, August 19 |
| » Lost to Tigers (77-44), 3-2 | Tiger Stadium (2-5) | 57-68 | Lost 4 |
| » Starters: Dave Hillman vs Don Mossi | Sixth | 25 out |
| Sunday, August 20 |
| » Lost to Tigers (78-44), 6-1 | Tiger Stadium (2-6) | 57-69 | Lost 5 |
| » Starters: Gene Conley vs Frank Lary | Fifth | 27 out |
| » Lost to Tigers (79-44), 7-6 | Tiger Stadium (2-7) | 57-70 | Lost 6 |
| » Starters: Tracy Stallard vs Jim Bunning | Fifth | 27 out |
| Tuesday, August 22 |
| » Defeated Senators (50-71), 3-2 | Fenway Park (39-25) | 58-70 | |
| » Starters: Bennie Daniels vs Don Schwall | Sixth | 26 out |
| Wednesday, August 23 |
| » Defeated Senators (50-72), 9-4 | Fenway Park (40-25) | 59-70 | Won 2 |
| » Starters: Joe McClain vs Bill Monbouquette | Fifth | 26 out |
| Thursday, August 24 |
| » Defeated Senators (50-73), 5-4 | Fenway Park (41-25) | 60-70 | Won 3 |
| » Starters: Dick Donovan vs Ike Delock | Fifth | 25 out |
| Friday, August 25 |
| » Defeated Angels (54-72), 12-6 | Wrigley Field (4-3) | 61-70 | Won 4 |
| » Starters: Gene Conley vs Ron Moeller | Sixth | 25 out |
| Saturday, August 26 |
| » Lost to Angels (55-72), 5-2 | Wrigley Field (4-4) | 61-71 | |
| » Starters: Tracy Stallard vs Ken McBride | Sixth | 26 out |
| Sunday, August 27 |
| » Lost to Angels (56-72), 8-3 | Wrigley Field (4-5) | 61-72 | Lost 2 |
| » Starters: Don Schwall vs Eli Grba | Sixth | 27 out |
| Future Red Sox Mike Maddux is born in Dayton, OH. |
| Monday, August 28 |
| » Defeated Athletics (46-83), 4-3 | Municipal Stadium (3-4) | 62-72 | |
| » Starters: Bill Monbouquette vs Norm Bass | Sixth | 26½ out |
| Tuesday, August 29 |
| » Defeated Athletics (46-84), 8-4 | Municipal Stadium (4-4) | 63-72 | Won 2 |
| » Starters: Ike Delock vs Ed Rakow | Sixth | 25½ out |
| Wednesday, August 30 |
| » Defeated Athletics (46-85), 9-3 | Municipal Stadium (5-4) | 64-72 | Won 3 |
| » Starters: Gene Conley vs Jim Archer | Sixth | 25½ out |
| Thursday, August 31 |
| Future Red Sox Mike Hartley is born in Hawthorne, CA. |
| Friday, September 1 |
| » Lost to Twins (58-74), 5-1 | Metropolitan Stadium (3-4) | 64-73 | |
| » Starters: Don Schwall vs Pedro Ramos | Sixth | 26 out |
| Saturday, September 2 |
| » Defeated Twins (58-75), 2-1 | Metropolitan Stadium (4-4) | 65-73 | |
| » Starters: Bill Monbouquette vs Don Lee | Sixth | 26 out |
| Sunday, September 3 |
| » Defeated Twins (58-76), 8-6 | Metropolitan Stadium (5-4) | 66-73 | Won 2 |
| » Starters: Tracy Stallard vs Camilo Pascual | Sixth | 26 out |
| Monday, September 4 |
| » Lost to Indians (70-68), 7-2 | Fenway Park (41-26) | 66-74 | |
| » Starters: Mudcat Grant vs Ike Delock | Sixth | 27½ out |
| Tuesday, September 5 |
| » Lost to Indians (71-68), 9-5 | Fenway Park (41-27) | 66-75 | Lost 2 |
| » Starters: Barry Latman vs Gene Conley | Sixth | 28½ out |
| Wednesday, September 6 |
| » Defeated Indians (71-69), 9-4 | Fenway Park (42-27) | 67-75 | |
| » Starters: Jim Perry vs Don Schwall | Sixth | 28½ out |
| Thursday, September 7 |
| » Defeated Tigers (86-54), 8-4 | Fenway Park (43-27) | 68-75 | Won 2 |
| » Starters: Frank Lary vs Bill Monbouquette | Sixth | 28½ out |
| Friday, September 8 |
| » Defeated Tigers (86-55), 9-2 | Fenway Park (44-27) | 69-75 | Won 3 |
| » Starters: Jim Bunning vs Tracy Stallard | Sixth | 28½ out |
| » Major-league debuts: Howie Koplitz (Tigers) |
| Saturday, September 9 |
| » Lost to Tigers (87-55), 3-1 | Fenway Park (44-28) | 69-76 | |
| » Starters: Ron Kline vs Ike Delock | Sixth | 29½ out |
| Sunday, September 10 |
| » Defeated Tigers (87-56), 8-7 | Fenway Park (45-28) | 70-76 | |
| » Starters: Don Mossi vs Gene Conley | Sixth | 30 out |
| Monday, September 11 |
| » Defeated Senators (52-93), 14-4 | Griffith Stadium (2-5) | 71-76 | Won 2 |
| » Starters: Don Schwall vs Tom Cheney | Sixth | 29½ out |
| Tuesday, September 12 |
| » Lost to Senators (53-93), 5-1 | Griffith Stadium (2-6) | 71-77 | |
| » Starters: Bill Monbouquette vs Pete Burnside | Sixth | 30½ out |
| Wednesday, September 13 |
| » Lost to Senators (54-93), 4-2 | Griffith Stadium (2-7) | 71-78 | Lost 2 |
| » Starters: Tracy Stallard vs Ed Hobaugh | Sixth | 31 out |
| Thursday, September 14 |
| » Major-league debuts: Jim Fregosi (Angels) |
| Friday, September 15 |
| » Defeated Orioles (87-62), 3-2 | Fenway Park (46-28) | 72-78 | |
| » Starters: Milt Pappas vs Gene Conley | Sixth | 29½ out |
| Saturday, September 16 |
| » Lost to Orioles (88-62), 5-4 | Fenway Park (46-29) | 72-79 | |
| » Starters: Jack Fisher vs Don Schwall | Sixth | 29½ out |
| Sunday, September 17 |
| » Defeated Orioles (88-63), 1-0 | Fenway Park (47-29) | 73-79 | |
| » Starters: Chuck Estrada vs Bill Monbouquette | Sixth | 29½ out |
| Tuesday, September 19 |
| » Lost to White Sox (83-70), 5-1 | Comiskey Park I (3-5) | 73-80 | |
| » Starters: Tracy Stallard vs Juan Pizarro | Sixth | 30 out |
| Wednesday, September 20 |
| » Lost to White Sox (84-70), 3-1 | Comiskey Park I (3-6) | 73-81 | Lost 2 |
| » Starters: Gene Conley vs Ray Herbert | Sixth | 31 out |
| Saturday, September 23 |
| » Lost to Yankees (105-51), 8-3 | Fenway Park (47-30) | 73-82 | Lost 3 |
| » Starters: Whitey Ford vs Don Schwall | Sixth | 31½ out |
| Sunday, September 24 |
| » Defeated Yankees (105-52), 3-1 | Fenway Park (48-30) | 74-82 | |
| » Starters |
