| Sunday, March 26 |
| Future Oriole Mickey Weston is born in Flint, MI. |
| Tuesday, March 28 |
| Future Oriole Glenn Davis is born in Jacksonville, FL. |
| Tuesday, April 4 |
| Future Oriole Brad Komminsk is born in Lima, OH. |
| Tuesday, April 11 |
| » Lost to Angels (1-0), 7-2 | Memorial Stadium (0-1) | 0-1 | |
| » Starters: Eli Grba vs Milt Pappas | Second | 1 out |
| Friday, April 14 |
| » Lost to Twins (2-0), 3-2 | Memorial Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Camilo Pascual vs Jack Fisher | Fifth | 2 out |
| Future Oriole Jay Aldrich is born in Alexandria, LA. |
| Saturday, April 15 |
| » Defeated Twins (2-1), 8-0 | Memorial Stadium (1-2) | 1-2 | |
| » Starters: Chuck Stobbs vs Steve Barber | Third | 1 out |
| » Major-league debuts: Lee Stange (Twins) |
| Sunday, April 16 |
| » Lost to Twins (3-1), 10-5 | Memorial Stadium (1-3) | 1-3 | |
| » Starters: Pedro Ramos vs Chuck Estrada | Seventh | 3 out |
| » Lost to Twins (4-1), 6-4 | Memorial Stadium (1-4) | 1-4 | Lost 2 |
| » Starters: Jack Kralick vs Hal Brown | Seventh | 3 out |
| » Major-league debuts: Bill Pleis (Twins) |
| Wednesday, April 19 |
| » Major-league debuts: Ed Hobaugh (Senators) |
| Friday, April 21 |
| » Lost to Yankees (5-1), 4-2 | Memorial Stadium (1-5) | 1-5 | Lost 3 |
| » Starters: Whitey Ford vs Steve Barber | Eighth | 4 out |
| Saturday, April 22 |
| » Defeated Yankees (5-2), 5-3 | Memorial Stadium (2-5) | 2-5 | |
| » Starters: Ralph Terry vs Jack Fisher | Ninth | 3½ out |
| » Tied Yankees, 5-5 | Memorial Stadium (2-5) | 2-5 | |
| » Starters: Jim Coates vs Hal Brown | Ninth | 3½ out |
| » Major-league debuts: Lee Thomas (Yankees) |
| Future Oriole Jimmy Key is born in Huntsville, AL. |
| Sunday, April 23 |
| » Defeated Yankees (5-3), 4-1 | Memorial Stadium (3-5) | 3-5 | Won 2 |
| » Starters: Danny McDevitt vs Chuck Estrada | Seventh | 4 out |
| » Major-league debuts: Jack Reed and Rollie Sheldon (Yankees) |
| Monday, April 24 |
| » Lost to Indians (6-4), 5-1 | Memorial Stadium (3-6) | 3-6 | |
| » Starters: Jim Perry vs Milt Pappas | Seventh | 5 out |
| Tuesday, April 25 |
| » Defeated Indians (6-5), 5-2 | Memorial Stadium (4-6) | 4-6 | |
| » Starters: Gary Bell vs Steve Barber | Sixth | 4½ out |
| Wednesday, April 26 |
| » Lost to Indians (7-5), 6-3 | Memorial Stadium (4-7) | 4-7 | |
| » Starters: Mudcat Grant vs Jack Fisher | Eighth | 4½ out |
| Thursday, April 27 |
| » Defeated Senators (4-8), 5-0 | Griffith Stadium (1-0) | 5-7 | |
| » Starters: Dick Hall vs Joe McClain | Seventh | 4 out |
| Friday, April 28 |
| » Defeated Senators (4-9), 4-2 | Griffith Stadium (2-0) | 6-7 | Won 2 |
| » Starters: Chuck Estrada vs Bennie Daniels | Sixth | 3 out |
| Saturday, April 29 |
| » Defeated Senators (4-10), 5-0 | Griffith Stadium (3-0) | 7-7 | Won 3 |
| » Starters: Milt Pappas vs Ed Hobaugh | Fifth | 3 out |
| Sunday, April 30 |
| » Lost to Tigers (10-3), 8-2 | Tiger Stadium (0-1) | 7-8 | |
| » Starters: Steve Barber vs Don Mossi | Sixth | 3 out |
| » Defeated Tigers (10-4), 4-2 | Tiger Stadium (1-1) | 8-8 | |
| » Starters: Hal Brown vs Paul Foytack | Sixth | 3 out |
| Tuesday, May 2 |
| » Defeated Angels (4-10), 7-6 | Wrigley Field (1-0) | 9-8 | Won 2 |
| » Starters: Dick Hall vs Eli Grba | Fourth | 3 out |
| Wednesday, May 3 |
| » Lost to Angels (5-10), 7-6 | Wrigley Field (1-1) | 9-9 | |
| » Starters: Chuck Estrada vs Ron Kline | Third | 3 out |
| Thursday, May 4 |
| » Defeated Angels (5-11), 8-7 | Wrigley Field (2-1) | 10-9 | |
| » Starters: Milt Pappas vs Ken McBride | Third | 3 out |
| Saturday, May 6 |
| » Defeated Athletics (7-9), 6-0 | Municipal Stadium (1-0) | 11-9 | Won 2 |
| » Starters: Steve Barber vs Ken Johnson | Third | 3½ out |
| Sunday, May 7 |
| » Lost to Athletics (8-9), 5-4 | Municipal Stadium (1-1) | 11-10 | |
| » Starters: Jack Fisher vs Jerry Walker | Third | 5 out |
| Tuesday, May 9 |
| » Defeated Twins (11-11), 13-5 | Metropolitan Stadium (1-0) | 12-10 | |
| » Starters: Chuck Estrada vs Pedro Ramos | Third | 4½ out |
| Wednesday, May 10 |
| » Lost to Twins (12-11), 10-6 | Metropolitan Stadium (1-1) | 12-11 | |
| » Starters: Dick Hall vs Jack Kralick | Third | 5½ out |
| Thursday, May 11 |
| » Defeated Twins (12-12), 8-7 | Metropolitan Stadium (2-1) | 13-11 | |
| » Starters: Steve Barber vs Camilo Pascual | Third | 4½ out |
| Friday, May 12 |
| » Defeated Indians (12-12), 4-2 | Cleveland Stadium (1-0) | 14-11 | Won 2 |
| » Starters: Jack Fisher vs Johnny Antonelli | Third | 4½ out |
| Saturday, May 13 |
| » Defeated Indians (12-13), 4-1 | Cleveland Stadium (2-0) | 15-11 | Won 3 |
| » Starters: Hal Brown vs Wynn Hawkins | Third | 4½ out |
| Sunday, May 14 |
| » Lost to Indians (13-13), 1-0 | Cleveland Stadium (2-1) | 15-12 | |
| » Starters: Billy Hoeft vs Jim Perry | Fourth | 4½ out |
| » Lost to Indians (14-13), 6-4 | Cleveland Stadium (2-2) | 15-13 | Lost 2 |
| » Starters: Chuck Estrada vs Gary Bell | Fourth | 4½ out |
| Monday, May 15 |
| » Lost to Tigers (21-9), 10-5 | Memorial Stadium (4-8) | 15-14 | Lost 3 |
| » Starters: Paul Foytack vs Dick Hall | Fifth | 5½ out |
| Tuesday, May 16 |
| » Lost to Tigers (22-9), 10-4 | Memorial Stadium (4-9) | 15-15 | Lost 4 |
| » Starters: Frank Lary vs Steve Barber | Fifth | 6½ out |
| Wednesday, May 17 |
| » Lost to Tigers (23-9), 9-1 | Memorial Stadium (4-10) | 15-16 | Lost 5 |
| » Starters: Phil Regan vs Jack Fisher | Fifth | 7½ out |
| Friday, May 19 |
| » Defeated Senators (15-18), 4-2 | Memorial Stadium (5-10) | 16-16 | |
| » Starters: Tom Sturdivant vs Billy Hoeft | Fourth | 6½ out |
| Future Oriole Ken Gerhart is born in Charleston, SC. |
| Saturday, May 20 |
| » Defeated Senators (15-19), 4-3 | Memorial Stadium (6-10) | 17-16 | Won 2 |
| » Starters: Joe McClain vs Hal Brown | Fourth | 5½ out |
| Sunday, May 21 |
| » Lost to Yankees (17-14), 4-2 | Yankee Stadium (0-1) | 17-17 | |
| » Starters: Chuck Estrada vs Whitey Ford | Fifth | 6 out |
| » Defeated Yankees (17-15), 3-2 | Yankee Stadium (1-1) | 18-17 | |
| » Starters: Steve Barber vs Rollie Sheldon | Fifth | 6 out |
| Monday, May 22 |
| » Lost to Yankees (18-15), 8-2 | Yankee Stadium (1-2) | 18-18 | |
| » Starters: Jack Fisher vs Art Ditmar | Fifth | 7 out |
| Tuesday, May 23 |
| » Defeated White Sox (14-21), 3-1 | Memorial Stadium (7-10) | 19-18 | |
| » Starters: Billy Pierce vs Billy Hoeft | Fourth | 7 out |
| Wednesday, May 24 |
| » Defeated White Sox (14-22), 2-1 | Memorial Stadium (8-10) | 20-18 | Won 2 |
| » Starters: Bob Shaw vs Hal Brown | Fourth | 6½ out |
| » Defeated White Sox (14-23), 5-3 | Memorial Stadium (9-10) | 21-18 | Won 3 |
| » Starters: Russ Kemmerer vs Dick Hall | Fourth | 6½ out |
| Thursday, May 25 |
| » Defeated White Sox (14-24), 6-4 | Memorial Stadium (10-10) | 22-18 | Won 4 |
| » Starters: Herb Score vs Steve Barber | Fourth | 5½ out |
| Saturday, May 27 |
| » Defeated Red Sox (15-21), 5-4 | Memorial Stadium (11-10) | 23-18 | Won 5 |
| » Starters: Bill Monbouquette vs Chuck Estrada | Fourth | 4 out |
| Sunday, May 28 |
| » Lost to Red Sox (16-21), 5-0 | Memorial Stadium (11-11) | 23-19 | |
| » Starters: Don Schwall vs Jack Fisher | Fourth | 5 out |
| Tuesday, May 30 |
| » Defeated White Sox (15-26), 6-0 | Comiskey Park I (1-0) | 24-19 | |
| » Starters: Steve Barber vs Bob Shaw | Third | 4 out |
| » Defeated White Sox (15-27), 2-1 | Comiskey Park I (2-0) | 25-19 | Won 2 |
| » Starters: Hal Brown vs Billy Pierce | Third | 4 out |
| Wednesday, May 31 |
| » Lost to White Sox (16-27), 9-4 | Comiskey Park I (2-1) | 25-20 | |
| » Starters: Chuck Estrada vs Frank Baumann | Fourth | 4 out |
| Friday, June 2 |
| » Lost to Red Sox (19-23), 4-2 | Fenway Park (0-1) | 25-21 | Lost 2 |
| » Starters: Billy Hoeft vs Don Schwall | Fourth | 5 out |
| Saturday, June 3 |
| » Defeated Red Sox (19-24), 3-1 | Fenway Park (1-1) | 26-21 | |
| » Starters: Jack Fisher vs Ike Delock | Fourth | 5 out |
| Sunday, June 4 |
| » Lost to Red Sox (20-24), 6-5 | Fenway Park (1-2) | 26-22 | |
| » Starters: Steve Barber vs Gene Conley | Fourth | 6½ out |
| Monday, June 5 |
| » Lost to Angels (17-30), 3-0 | Memorial Stadium (11-12) | 26-23 | Lost 2 |
| » Starters: Ron Moeller vs Hal Brown | Fourth | 6½ out |
| Tuesday, June 6 |
| » Lost to Angels (18-30), 7-3 | Memorial Stadium (11-13) | 26-24 | Lost 3 |
| » Starters: Eli Grba vs Milt Pappas | Fourth | 6 out |
| » Defeated Angels (18-31), 2-0 | Memorial Stadium (12-13) | 27-24 | |
| » Starters: Ken McBride vs Chuck Estrada | Fourth | 6 out |
| Wednesday, June 7 |
| » Lost to Angels (19-31), 4-0 | Memorial Stadium (12-14) | 27-25 | |
| » Starters: Ted Bowsfield vs Billy Hoeft | Fourth | 7 out |
| Thursday, June 8 |
| » Lost to Twins (20-32), 3-1 | Memorial Stadium (12-15) | 27-26 | Lost 2 |
| » Starters: Jim Kaat vs Jack Fisher | Fourth | 7½ out |
| Saturday, June 10 |
| » Defeated Twins (20-33), 4-3 | Memorial Stadium (13-15) | 28-26 | |
| » Starters: Camilo Pascual vs Hal Brown | Fourth | 7 out |
| Sunday, June 11 |
| » Defeated White Sox (19-33), 8-2 | Memorial Stadium (14-15) | 29-26 | Won 2 |
| » Starters: Frank Baumann vs Chuck Estrada | Fourth | 8 out |
| » Lost to White Sox (20-33), 7-1 | Memorial Stadium (14-16) | 29-27 | |
| » Starters: Billy Pierce vs Steve Barber | Fourth | 8 out |
| Monday, June 12 |
| » Lost to White Sox (21-33), 9-8 | Memorial Stadium (14-17) | 29-28 | Lost 2 |
| » Starters: Russ Kemmerer vs Billy Hoeft | Fourth | 8 out |
| Tuesday, June 13 |
| » Defeated Senators (28-30), 8-7 | Memorial Stadium (15-17) | 30-28 | |
| » Starters: Pete Burnside vs Jack Fisher | Fourth | 8 out |
| Wednesday, June 14 |
| » Lost to Senators (29-30), 5-1 | Memorial Stadium (15-18) | 30-29 | |
| » Starters: Dick Donovan vs Steve Barber | Third | 8 out |
| Thursday, June 15 |
| » Lost to Senators (30-30), 5-2 | Memorial Stadium (15-19) | 30-30 | Lost 2 |
| » Starters: Ed Hobaugh vs Hal Brown | Third | 8 out |
| Friday, June 16 |
| » Lost to Indians (39-22), 3-1 | Cleveland Stadium (2-3) | 30-31 | Lost 3 |
| » Starters: Chuck Estrada vs Dick Stigman | Fourth | 9 out |
| Saturday, June 17 |
| » Defeated Indians (39-23), 4-1 | Cleveland Stadium (3-3) | 31-31 | |
| » Starters: Milt Pappas vs Wynn Hawkins | Fifth | 9 out |
| Sunday, June 18 |
| » Lost to Indians (40-23), 2-1 | Cleveland Stadium (3-4) | 31-32 | |
| » Starters: Steve Barber vs Jim Perry | Fifth | 8½ out |
| » Defeated Indians (40-24), 8-5 | Cleveland Stadium (4-4) | 32-32 | |
| » Starters: Jack Fisher vs Gary Bell | Fifth | 8½ out |
| Tuesday, June 20 |
| » Lost to Twins (25-39), 5-4 | Metropolitan Stadium (2-2) | 32-33 | |
| » Starters: Hal Brown vs Jack Kralick | Fifth | 9½ out |
| Wednesday, June 21 |
| » Defeated Twins (25-40), 11-5 | Metropolitan Stadium (3-2) | 33-33 | |
| » Starters: Chuck Estrada vs Pedro Ramos | Fifth | 9 out |
| Thursday, June 22 |
| » Defeated Twins (25-41), 8-2 | Metropolitan Stadium (4-2) | 34-33 | Won 2 |
| » Starters: Milt Pappas vs Jim Kaat | Fifth | 9 out |
| Friday, June 23 |
| » Defeated Angels (24-45), 8-6 | Wrigley Field (3-1) | 35-33 | Won 3 |
| » Starters: Steve Barber vs Ted Bowsfield | Fifth | 9 out |
| Saturday, June 24 |
| » Lost to Angels (25-45), 4-1 | Wrigley Field (3-2) | 35-34 | |
| » Starters: Dick Hall vs Ron Moeller | Fifth | 10 out |
| Sunday, June 25 |
| » Defeated Angels (25-46), 9-8 | Wrigley Field (4-2) | 36-34 | |
| » Starters: Hal Brown vs Eli Grba | Fifth | 9½ out |
| Tuesday, June 27 |
| » Defeated Athletics (29-39), 5-3 | Municipal Stadium (2-1) | 37-34 | Won 2 |
| » Starters: Milt Pappas vs Norm Bass | Fourth | 7½ out |
| » Defeated Athletics (29-40), 7-2 | Municipal Stadium (3-1) | 38-34 | Won 3 |
| » Starters: Chuck Estrada vs Art Ditmar | Fourth | 7½ out |
| Wednesday, June 28 |
| » Defeated Athletics (29-41), 5-4 | Municipal Stadium (4-1) | 39-34 | Won 4 |
| » Starters: Steve Barber vs Jim Archer | Fourth | 7½ out |
| Thursday, June 29 |
| » Defeated Athletics (29-42), 6-2 | Municipal Stadium (5-1) | 40-34 | Won 5 |
| » Starters: Dick Hall vs Lew Krausse | Fourth | 7½ out |
| Friday, June 30 |
| » Lost to Tigers (48-26), 6-5 | Memorial Stadium (15-20) | 40-35 | |
| » Starters: Jim Bunning vs Jack Fisher | Fourth | 8½ out |
| Saturday, July 1 |
| » Lost to Tigers (49-26), 11-8 | Memorial Stadium (15-21) | 40-36 | Lost 2 |
| » Starters: Bob Bruce vs Hal Brown | Fourth | 9½ out |
| » Major-league debuts: Fred Gladding (Tigers) |
| Sunday, July 2 |
| » Defeated Tigers (49-27), 6-3 | Memorial Stadium (16-21) | 41-36 | |
| » Starters: Phil Regan vs Chuck Estrada | Fourth | 8½ out |
| Monday, July 3 |
| » Defeated Indians (45-34), 5-0 | Memorial Stadium (17-21) | 42-36 | Won 2 |
| » Starters: Jim Perry vs Milt Pappas | Fourth | 8 out |
| Tuesday, July 4 |
| » Defeated Indians (45-35), 5-1 | Memorial Stadium (18-21) | 43-36 | Won 3 |
| » Starters: Wynn Hawkins vs Steve Barber | Fourth | 7½ out |
| Wednesday, July 5 |
| » Defeated Senators (35-45), 2-0 | Griffith Stadium (4-0) | 44-36 | Won 4 |
| » Starters: Dick Hall vs Bennie Daniels | Fourth | 7 out |
| Thursday, July 6 |
| » Lost to Senators (36-45), 1-0 | Griffith Stadium (4-1) | 44-37 | |
| » Starters: Wes Stock vs Dick Donovan | Fourth | 8 out |
| Friday, July 7 |
| » Defeated Athletics (31-49), 6-2 | Memorial Stadium (19-21) | 45-37 | |
| » Starters: Ed Rakow vs Chuck Estrada | Third | 7 out |
| » Defeated Athletics (31-50), 5-0 | Memorial Stadium (20-21) | 46-37 | Won 2 |
| » Starters: Jim Archer vs Hal Brown | Third | 7 out |
| Saturday, July 8 |
| » Defeated Athletics (31-51), 7-2 | Memorial Stadium (21-21) | 47-37 | Won 3 |
| » Starters: Lew Krausse vs Milt Pappas | Third | 7 out |
| Sunday, July 9 |
| » Defeated Athletics (31-52), 8-0 | Memorial Stadium (22-21) | 48-37 | Won 4 |
| » Starters: Bob Shaw vs Steve Barber | Third | 7 out |
| Thursday, July 13 |
| » Lost to Red Sox (41-45), 3-2 | Fenway Park (1-3) | 48-38 | |
| » Starters: Milt Pappas vs Don Schwall | Third | 7½ out |
| Friday, July 14 |
| » Defeated Red Sox (41-46), 7-6 | Fenway Park (2-3) | 49-38 | |
| » Starters: Chuck Estrada vs Bill Monbouquette | Third | 6½ out |
| Future Oriole Vic Rodriguez is born in New York, NY. |
| Saturday, July 15 |
| » Lost to Red Sox (42-46), 2-1 | Fenway Park (2-4) | 49-39 | |
| » Starters: Dick Hall vs Gene Conley | Third | 7½ out |
| Sunday, July 16 |
| » Lost to Yankees (56-30), 2-1 | Memorial Stadium (22-22) | 49-40 | Lost 2 |
| » Starters: Bud Daley vs Steve Barber | Third | 9 out |
| Monday, July 17 |
| » Lost to Yankees (57-30), 5-0 | Memorial Stadium (22-23) | 49-41 | Lost 3 |
| » Starters: Whitey Ford vs Milt Pappas | Third | 10 out |
| Tuesday, July 18 |
| » Defeated Tigers (59-32), 8-7 | Tiger Stadium (2-1) | 50-41 | |
| » Starters: Chuck Estrada vs Frank Lary | Third | 9½ out |
| Wednesday, July 19 |
| » Defeated Tigers (59-33), 4-2 | Tiger Stadium (3-1) | 51-41 | Won 2 |
| » Starters: Jack Fisher vs Jim Bunning | Third | 8 out |
| Thursday, July 20 |
| » Lost to Tigers (60-33), 15-8 | Tiger Stadium (3-2) | 51-42 | |
| » Starters: Steve Barber vs Don Mossi | Third | 9 out |
| Saturday, July 22 |
| » Lost to White Sox (48-47), 7-4 | Comiskey Park I (2-2) | 51-43 | Lost 2 |
| » Starters: Dick Hall vs Early Wynn | Fourth | 10½ out |
| » Lost to White Sox (49-47), 11-4 | Comiskey Park I (2-3) | 51-44 | Lost 3 |
| » Starters: Milt Pappas vs Billy Pierce | Fourth | 10½ out |
| Sunday, July 23 |
| » Lost to White Sox (50-47), 5-2 | Comiskey Park I (2-4) | 51-45 | Lost 4 |
| » Starters: Chuck Estrada vs Cal McLish | Fourth | 11 out |
| Tuesday, July 25 |
| » Defeated Red Sox (45-54), 5-1 | Memorial Stadium (23-23) | 52-45 | |
| » Starters: Ike Delock vs Steve Barber | Third | 11 out |
| Wednesday, July 26 |
| » Defeated Red Sox (45-55), 5-1 | Memorial Stadium (24-23) | 53-45 | Won 2 |
| » Starters: Bill Monbouquette vs Billy Hoeft | Third | 10½ out |
| » Defeated Red Sox (45-56), 9-2 | Memorial Stadium (25-23) | 54-45 | Won 3 |
| » Starters: Gene Conley vs Jack Fisher | Third | 10½ out |
| Thursday, July 27 |
| » Defeated Red Sox (45-57), 8-5 | Memorial Stadium (26-23) | 55-45 | Won 4 |
| » Starters: Tracy Stallard vs Chuck Estrada | Third | 10½ out |
| Friday, July 28 |
| » Defeated Yankees (64-34), 4-0 | Yankee Stadium (2-2) | 56-45 | Won 5 |
| » Starters: Hal Brown vs Bud Daley | Third | 9½ out |
| Saturday, July 29 |
| » Lost to Yankees (65-34), 5-4 | Yankee Stadium (2-3) | 56-46 | |
| » Starters: Hoyt Wilhelm vs Whitey Ford | Third | 10½ out |
| Sunday, July 30 |
| » Defeated Yankees (65-35), 4-0 | Yankee Stadium (3-3) | 57-46 | |
| » Starters: Steve Barber vs Bill Stafford | Third | 8½ out |
| » Defeated Yankees (65-36), 2-1 | Yankee Stadium (4-3) | 58-46 | Won 2 |
| » Starters: Milt Pappas vs Rollie Sheldon | Third | 8½ out |
| Wednesday, August 2 |
| » Lost to Twins (46-56), 4-3 | Memorial Stadium (26-24) | 58-47 | |
| » Starters: Don Lee vs Chuck Estrada | Third | 9½ out |
| » Defeated Twins (46-57), 4-3 | Memorial Stadium (27-24) | 59-47 | |
| » Starters: Pedro Ramos vs Dick Hall | Third | 9½ out |
| Thursday, August 3 |
| » Defeated Twins (46-58), 3-0 | Memorial Stadium (28-24) | 60-47 | Won 2 |
| » Starters: Jim Kaat vs Hal Brown | Third | 8½ out |
| Friday, August 4 |
| » Lost to Angels (46-60), 3-1 | Memorial Stadium (28-25) | 60-48 | |
| » Starters: Ted Bowsfield vs Steve Barber | Third | 9 out |
| » Defeated Angels (46-61), 3-0 | Memorial Stadium (29-25) | 61-48 | |
| » Starters: Eli Grba vs Jack Fisher | Third | 9 out |
| Saturday, August 5 |
| » Lost to Angels (47-61), 4-2 | Memorial Stadium (29-26) | 61-49 | |
| » Starters: Ron Kline vs Milt Pappas | Third | 10 out |
| Monday, August 7 |
| » Defeated Athletics (40-68), 5-4 | Memorial Stadium (30-26) | 62-49 | |
| » Starters: Art Ditmar vs Chuck Estrada | Third | 11 out |
| Tuesday, August 8 |
| » Defeated Athletics (40-69), 7-0 | Memorial Stadium (31-26) | 63-49 | Won 2 |
| » Starters: Bob Shaw vs Steve Barber | Third | 11½ out |
| » Lost to Athletics (41-69), 6-5 | Memorial Stadium (31-27) | 63-50 | |
| » Starters: Norm Bass vs Hal Brown | Third | 11½ out |
| Wednesday, August 9 |
| » Lost to Athletics (42-69), 2-1 | Memorial Stadium (31-28) | 63-51 | Lost 2 |
| » Starters: Jerry Walker vs Jack Fisher | Third | 12½ out |
| Thursday, August 10 |
| » Defeated Athletics (42-70), 8-0 | Memorial Stadium (32-28) | 64-51 | |
| » Starters: Bill Kunkel vs Milt Pappas | Third | 12½ out |
| Friday, August 11 |
| » Defeated Red Sox (56-62), 6-3 | Memorial Stadium (33-28) | 65-51 | Won 2 |
| » Starters: Chet Nichols vs Billy Hoeft | Third | 12½ out |
| Saturday, August 12 |
| » Defeated Red Sox (56-63), 8-3 | Memorial Stadium (34-28) | 66-51 | Won 3 |
| » Starters: Ike Delock vs Dick Hall | Third | 11½ out |
| Sunday, August 13 |
| » Defeated Red Sox (56-64), 6-5 | Memorial Stadium (35-28) | 67-51 | Won 4 |
| » Starters: Bill Monbouquette vs Steve Barber | Third | 11 out |
| Tuesday, August 15 |
| » Lost to Tigers (74-42), 2-0 | Tiger Stadium (3-3) | 67-52 | |
| » Starters: Chuck Estrada vs Frank Lary | Third | 11½ out |
| » Lost to Tigers (75-42), 3-2 | Tiger Stadium (3-4) | 67-53 | Lost 2 |
| » Starters: Hal Brown vs Don Mossi | Third | 11½ out |
| Wednesday, August 16 |
| » Defeated Tigers (75-43), 8-2 | Tiger Stadium (4-4) | 68-53 | |
| » Starters: Milt Pappas vs Jim Bunning | Third | 11½ out |
| Thursday, August 17 |
| » Defeated Tigers (75-44), 3-1 | Tiger Stadium (5-4) | 69-53 | Won 2 |
| » Starters: Jack Fisher vs Paul Foytack | Third | 11½ out |
| Friday, August 18 |
| » Defeated Senators (50-68), 3-2 | Griffith Stadium (5-1) | 70-53 | Won 3 |
| » Starters: Steve Barber vs Joe McClain | Third | 10½ out |
| Saturday, August 19 |
| » Defeated Senators (50-69), 5-0 | Griffith Stadium (6-1) | 71-53 | Won 4 |
| » Starters: Billy Hoeft vs Marty Kutyna | Third | 10½ out |
| Sunday, August 20 |
| » Defeated Senators (50-70), 9-3 | Griffith Stadium (7-1) | 72-53 | Won 5 |
| » Starters: Chuck Estrada vs Dick Donovan | Third | 11 out |
| Tuesday, August 22 |
| » Lost to Athletics (45-78), 3-2 | Municipal Stadium (5-2) | 72-54 | |
| » Starters: Milt Pappas vs Norm Bass | Third | 11 out |
| Wednesday, August 23 |
| » Defeated Athletics (45-79), 7-5 | Municipal Stadium (6-2) | 73-54 | |
| » Starters: Hal Brown vs Bob Shaw | Third | 11 out |
| Thursday, August 24 |
| » Lost to Athletics (46-79), 5-3 | Municipal Stadium (6-3) | 73-55 | |
| » Starters: Steve Barber vs Ed Rakow | Third | 11 out |
| Friday, August 25 |
| » Defeated Twins (55-71), 5-2 | Metropolitan Stadium (5-2) | 74-55 | |
| » Starters: Jack Fisher vs Jack Kralick | Third | 11 out |
| Saturday, August 26 |
| » Defeated Twins (55-72), 7-4 | Metropolitan Stadium (6-2) | 75-55 | Won 2 |
| » Starters: Chuck Estrada vs Al Schroll | Third | 11 out |
| Sunday, August 27 |
| » Defeated Twins (55-73), 3-0 | Metropolitan Stadium (7-2) | 76-55 | Won 3 |
| » Starters: Milt Pappas vs Pedro Ramos | Third | 11 out |
| Monday, August 28 |
| » Defeated Angels (56-73), 8-1 | Wrigley Field (5-2) | 77-55 | Won 4 |
| » Starters: Hal Brown vs Ted Bowsfield | Third | 10½ out |
| Tuesday, August 29 |
| » Lost to Angels (57-73), 6-5 | Wrigley Field (5-3) | 77-56 | |
| » Starters: Steve Barber vs Ryne Duren | Third | 11 out |
| » Lost to Angels (58-73), 6-5 | Wrigley Field (5-4) | 77-57 | Lost 2 |
| » Starters: Billy Hoeft vs Jack Spring | Third | 11 out |
| Wednesday, August 30 |
| » Defeated Angels (58-74), 11-4 | Wrigley Field (6-4) | 78-57 | |
| » Starters: Jack Fisher vs Ron Moeller | Third | 11 out |
| Thursday, August 31 |
| Future Oriole Mike Hartley is born in Hawthorne, CA. |
| Friday, September 1 |
| » Lost to Indians (68-66), 5-4 | Memorial Stadium (35-29) | 78-58 | |
| » Manager: Lum Harris |
| » Starters: Barry Latman vs Chuck Estrada | Third | 11½ out |
| Saturday, September 2 |
| » Defeated Indians (68-67), 3-2 | Memorial Stadium (36-29) | 79-58 | |
| » Starters: Dick Stigman vs Milt Pappas | Third | 12 out |
| » Lost to Indians (69-67), 6-0 | Memorial Stadium (36-30) | 79-59 | |
| » Starters: Jim Perry vs Hal Brown | Third | 12 out |
| Sunday, September 3 |
| » Defeated Indians (69-68), 1-0 | Memorial Stadium (37-30) | 80-59 | |
| » Starters: Gary Bell vs Steve Barber | Third | 12 out |
| Monday, September 4 |
| » Game at Memorial Stadium interrupted in the 9th inning with the score of Orioles 4, Tigers 1. Completed on September 05. |
| » Game at Memorial Stadium interrupted in the 9th inning with the score of Orioles 4, Tigers 1. Completed on September 05. |
| » Major-league debuts: Ron Nischwitz (Tigers) |
| Tuesday, September 5 |
| » Defeated Tigers (86-51), 1-0 | Memorial Stadium (38-30) | 81-59 | Won 2 |
| » Starters: Don Mossi vs Chuck Estrada | Third | 12 out |
| » Defeated Tigers (86-52), 6-3 | Memorial Stadium (39-30) | 82-59 | Won 3 |
| » Starters: Paul Foytack vs Jack Fisher | Third | 12 out |
| » Defeated Tigers (86-53), 4-1 | Memorial Stadium (40-30) | 83-59 | Won 4 |
| » Starters: Ron Kline vs Billy Hoeft | Third | 12 out |
| Wednesday, September 6 |
| Future Oriole Roy Smith is born in Mount Vernon, NY. |
| Thursday, September 7 |
| » Defeated Senators (51-89), 6-3 | Memorial Stadium (41-30) | 84-59 | Won 5 |
| » Starters: Carl Bouldin vs Milt Pappas | Third | 12½ out |
| Friday, September 8 |
| » Defeated Senators (51-90), 2-1 | Memorial Stadium (42-30) | 85-59 | Won 6 |
| » Starters: Pete Burnside vs Steve Barber | Third | 12 out |
| » Defeated Senators (51-91), 4-2 | Memorial Stadium (43-30) | 86-59 | Won 7 |
| » Starters: Ed Hobaugh vs Dick Hall | Third | 12 out |
| Saturday, September 9 |
| » Lost to Senators (52-91), 6-2 | Memorial Stadium (43-31) | 86-60 | |
| » Starters: Bennie Daniels vs Jack Fisher | Third | 13 out |
| » Major-league debuts: Ken Retzer (Senators) |
| Sunday, September 10 |
| » Defeated Senators (52-92), 3-2 | Memorial Stadium (44-31) | 87-60 | |
| » Starters: Joe McClain vs Chuck Estrada | Third | 13½ out |
| Wednesday, September 13 |
| » Lost to Indians (72-74), 5-0 | Cleveland Stadium (4-5) | 87-61 | |
| » Starters: Steve Barber vs Gary Bell | Third | 14½ out |
| Friday, September 15 |
| » Lost to Red Sox (72-78), 3-2 | Fenway Park (2-5) | 87-62 | Lost 2 |
| » Starters: Milt Pappas vs Gene Conley | Third | 14 out |
| Saturday, September 16 |
| » Defeated Red Sox (72-79), 5-4 | Fenway Park (3-5) | 88-62 | |
| » Starters: Jack Fisher vs Don Schwall | Third | 13 out |
| Future Oriole Mark Parent is born in Ashland, OR. Future Oriole Mark Parent is born in Ashland, OR. |
| Sunday, September 17 |
| » Lost to Red Sox (73-79), 1-0 | Fenway Park (3-6) | 88-63 | |
| » Starters: Chuck Estrada vs Bill Monbouquette | Third | 14 out |
| Tuesday, September 19 |
| » Defeated Yankees (102-50), 1-0 | Memorial Stadium (45-31) | 89-63 | |
| » Starters: Whitey Ford vs Steve Barber | Third | 14 out |
| » Lost to Yankees (103-50), 3-1 | Memorial Stadium (45-32) | 89-64 | |
| » Starters: Bud Daley vs Hal Brown | Third | 14 out |
| Wednesday, September 20 |
| » Lost to Yankees (104-50), 4-2 | Memorial Stadium (45-33) | 89-65 | Lost 2 |
| » Starters: Ralph Terry vs Milt Pappas | Third | 15 out |
| Thursday, September 21 |
| » Defeated Yankees (104-51), 5-3 | Memorial Stadium (46-33) | 90-65 | |
| » Starters: Bill Stafford vs Jack Fisher | Third | 14 out |
| Friday, September 22 |
| » Defeated White Sox (84-71), 8-6 | Comiskey Park I (3-4) | 91-65 | Won 2 |
| » Starters: Chuck Estrada vs Frank Baumann | Third | 13½ out |
| Sunday, September 24 |
| » Lost to White Sox (85-71), 8-7 | Comiskey Park I (3-5) | 91-66 | |
| » Starters: Steve Barber vs Joe Horlen | Third | 13½ out |
| » Defeated White Sox (85-72), 5-3 | Comiskey Park I (4-5) | 92-66 | |
| » Starters: Billy Hoeft vs Juan Pizarro | Third | 13½ out |
| Tuesday, September 26 |
| » Lost to Yankees (106-52), 3-2 | Yankee Stadium (4-4) | 92-67 | |
| » Starters: Jack Fisher vs Bud Daley | Third | |
