| Thursday, January 12 |
| Future Indian Casey Candaele is born in Lompoc, CA. |
| Sunday, January 29 |
| Future Indian Mike Aldrete is born in Carmel, CA. |
| Monday, January 30 |
| Former Indian Aaron Ward dies in New Orleans, LA at the age of 65. |
| Saturday, February 11 |
| Future Indian Steve Springer is born in Long Beach, CA. |
| Friday, February 17 |
| Former Indian Doc Johnston dies in Chattanooga, TN at the age of 74. |
| Tuesday, February 21 |
| Future Indian Joel Skinner is born in LaJolla, CA. |
| Wednesday, March 8 |
| Future Indian Mark Salas is born in Montebello, CA. |
| Saturday, March 11 |
| Future Indian Bryan Oelkers is born in Zaragoza, Spain. |
| Tuesday, April 4 |
| Future Indian Brad Komminsk is born in Lima, OH. |
| Sunday, April 9 |
| Future Indian Brian Dorsett is born in Terre Haute, IN. |
| Tuesday, April 11 |
| » Defeated Tigers (0-1), 9-5 | Tiger Stadium (1-0) | 1-0 | |
| » Starters: Jim Perry vs Jim Bunning | First | -- |
| » Major-league debuts: Jim Donohue and Jake Wood (Tigers) |
| Friday, April 14 |
| » Lost to Senators (1-1), 3-2 | Griffith Stadium (0-1) | 1-1 | |
| » Starters: Gary Bell vs Joe McClain | Third | 1 out |
| » Major-league debuts: Joe McClain (Senators) Bob Allen (Indians) |
| Former Indian Cy Falkenberg dies in San Francisco, CA at the age of 81. |
| Saturday, April 15 |
| » Defeated Senators (1-2), 3-1 | Griffith Stadium (1-1) | 2-1 | |
| » Starters: Mudcat Grant vs Bennie Daniels | First | -- |
| Former Indian Nick Cullop dies in Tazewell, VA at the age of 74. |
| Sunday, April 16 |
| » Defeated Senators (1-3), 3-2 | Griffith Stadium (2-1) | 3-1 | Won 2 |
| » Starters: Johnny Antonelli vs Dick Donovan | Second | ½ out |
| Wednesday, April 19 |
| » Lost to Tigers (3-1), 5-2 | Cleveland Stadium (0-1) | 3-2 | |
| » Starters: Jim Bunning vs Jim Perry | Fourth | 1½ out |
| » Major-league debuts: Bubba Morton and Mike Roarke (Tigers) |
| Thursday, April 20 |
| » Lost to Tigers (4-1), 11-4 | Cleveland Stadium (0-2) | 3-3 | Lost 2 |
| » Starters: Frank Lary vs Gary Bell | Fourth | 2 out |
| » Major-league debuts: Russ Heman (Indians) |
| Friday, April 21 |
| » Defeated Athletics (1-3), 5-3 | Municipal Stadium (1-0) | 4-3 | |
| » Starters: Mudcat Grant vs Ray Herbert | Third | 1½ out |
| Saturday, April 22 |
| » Lost to Athletics (2-3), 5-2 | Municipal Stadium (1-1) | 4-4 | |
| » Starters: Johnny Antonelli vs Bud Daley | Fifth | 2 out |
| Sunday, April 23 |
| » Defeated Athletics (2-4), 10-8 | Municipal Stadium (2-1) | 5-4 | |
| » Starters: Bobby Locke vs Jerry Walker | Fourth | 2½ out |
| » Major-league debuts: Steve Hamilton (Indians) |
| Monday, April 24 |
| » Defeated Orioles (3-6), 5-1 | Memorial Stadium (1-0) | 6-4 | Won 2 |
| » Starters: Jim Perry vs Milt Pappas | Third | 2½ out |
| Tuesday, April 25 |
| » Lost to Orioles (4-6), 5-2 | Memorial Stadium (1-1) | 6-5 | |
| » Starters: Gary Bell vs Steve Barber | Fourth | 3 out |
| Wednesday, April 26 |
| » Defeated Orioles (4-7), 6-3 | Memorial Stadium (2-1) | 7-5 | |
| » Starters: Mudcat Grant vs Jack Fisher | Fourth | 2 out |
| Thursday, April 27 |
| » Lost to Yankees (7-4), 4-3 | Yankee Stadium (0-1) | 7-6 | |
| » Starters: Johnny Antonelli vs Art Ditmar | Fifth | 2½ out |
| Saturday, April 29 |
| » Lost to Yankees (8-4), 4-2 | Yankee Stadium (0-2) | 7-7 | Lost 2 |
| » Starters: Jim Perry vs Ralph Terry | Fifth | 3 out |
| Sunday, April 30 |
| » Lost to Red Sox (7-6), 4-2 | Cleveland Stadium (0-3) | 7-8 | Lost 3 |
| » Starters: Bill Monbouquette vs Gary Bell | Sixth | 3 out |
| » Defeated Red Sox (7-7), 10-1 | Cleveland Stadium (1-3) | 8-8 | |
| » Starters: Gene Conley vs Wynn Hawkins | Sixth | 3 out |
| Tuesday, May 2 |
| » Defeated White Sox (7-8), 3-2 | Cleveland Stadium (2-3) | 9-8 | Won 2 |
| » Starters: Early Wynn vs Mudcat Grant | Fourth | 3 out |
| Wednesday, May 3 |
| » Defeated White Sox (7-9), 4-3 | Cleveland Stadium (3-3) | 10-8 | Won 3 |
| » Starters: Cal McLish vs Jim Perry | Second | 2 out |
| Friday, May 5 |
| » Lost to Senators (7-13), 5-2 | Cleveland Stadium (3-4) | 10-9 | |
| » Starters: Ed Hobaugh vs Johnny Antonelli | Third | 3½ out |
| Sunday, May 7 |
| » Defeated Senators (7-14), 4-2 | Cleveland Stadium (4-4) | 11-9 | |
| » Starters: Tom Sturdivant vs Wynn Hawkins | Third | 5 out |
| » Lost to Senators (8-14), 4-3 | Cleveland Stadium (4-5) | 11-10 | |
| » Starters: Pete Burnside vs Mudcat Grant | Third | 5 out |
| Tuesday, May 9 |
| » Lost to White Sox (8-13), 4-2 | Comiskey Park I (0-1) | 11-11 | Lost 2 |
| » Starters: Jim Perry vs Herb Score | Fifth | 5½ out |
| Wednesday, May 10 |
| » Defeated White Sox (8-14), 8-2 | Comiskey Park I (1-1) | 12-11 | |
| » Starters: Gary Bell vs Bob Shaw | Third | 5½ out |
| Friday, May 12 |
| » Lost to Orioles (14-11), 4-2 | Cleveland Stadium (4-6) | 12-12 | |
| » Starters: Jack Fisher vs Johnny Antonelli | Fifth | 6 out |
| Saturday, May 13 |
| » Lost to Orioles (15-11), 4-1 | Cleveland Stadium (4-7) | 12-13 | Lost 2 |
| » Starters: Hal Brown vs Wynn Hawkins | Fifth | 7 out |
| Sunday, May 14 |
| » Defeated Orioles (15-12), 1-0 | Cleveland Stadium (5-7) | 13-13 | |
| » Starters: Billy Hoeft vs Jim Perry | Fifth | 5 out |
| » Defeated Orioles (15-13), 6-4 | Cleveland Stadium (6-7) | 14-13 | Won 2 |
| » Starters: Chuck Estrada vs Gary Bell | Fifth | 5 out |
| Monday, May 15 |
| » Defeated Red Sox (10-16), 13-2 | Fenway Park (1-0) | 15-13 | Won 3 |
| » Starters: Mudcat Grant vs Tom Brewer | Fourth | 5 out |
| Tuesday, May 16 |
| » Lost to Red Sox (11-16), 8-7 | Fenway Park (1-1) | 15-14 | |
| » Starters: Wynn Hawkins vs Ike Delock | Fourth | 6 out |
| Wednesday, May 17 |
| » Defeated Red Sox (11-17), 1-0 | Fenway Park (2-1) | 16-14 | |
| » Starters: Bobby Locke vs Bill Monbouquette | Fourth | 6 out |
| Friday, May 19 |
| » Defeated Yankees (16-13), 9-7 | Cleveland Stadium (7-7) | 17-14 | Won 2 |
| » Starters: Bob Turley vs Jim Perry | Third | 5 out |
| Saturday, May 20 |
| » Defeated Yankees (16-14), 4-3 | Cleveland Stadium (8-7) | 18-14 | Won 3 |
| » Starters: Ralph Terry vs Gary Bell | Second | 4 out |
| Sunday, May 21 |
| » Defeated Twins (18-15), 9-0 | Metropolitan Stadium (1-0) | 19-14 | Won 4 |
| » Starters: Wynn Hawkins vs Pedro Ramos | Second | 3½ out |
| » Defeated Twins (18-16), 2-0 | Metropolitan Stadium (2-0) | 20-14 | Won 5 |
| » Starters: Mudcat Grant vs Don Lee | Second | 3½ out |
| Monday, May 22 |
| » Defeated Twins (18-17), 7-5 | Metropolitan Stadium (3-0) | 21-14 | Won 6 |
| » Starters: Bobby Locke vs Ed Palmquist | Second | 3½ out |
| Tuesday, May 23 |
| » Lost to Angels (13-21), 9-0 | Wrigley Field (0-1) | 21-15 | |
| » Starters: Jim Perry vs Ken McBride | Second | 4½ out |
| Wednesday, May 24 |
| » Defeated Angels (13-22), 7-1 | Wrigley Field (1-1) | 22-15 | |
| » Starters: Gary Bell vs Jerry Casale | Second | 4½ out |
| Thursday, May 25 |
| » Defeated Angels (13-23), 13-5 | Wrigley Field (2-1) | 23-15 | Won 2 |
| » Starters: Mudcat Grant vs Ron Moeller | Second | 3½ out |
| Saturday, May 27 |
| » Lost to Athletics (16-18), 7-5 | Cleveland Stadium (8-8) | 23-16 | |
| » Starters: Bud Daley vs Wynn Hawkins | Second | 3 out |
| Sunday, May 28 |
| » Defeated Athletics (16-19), 9-1 | Cleveland Stadium (9-8) | 24-16 | |
| » Starters: Ray Herbert vs Gary Bell | Second | 3½ out |
| » Lost to Athletics (17-19), 8-4 | Cleveland Stadium (9-9) | 24-17 | |
| » Starters: Norm Bass vs Jim Perry | Second | 3½ out |
| Tuesday, May 30 |
| » Defeated Twins (19-23), 4-3 | Cleveland Stadium (10-9) | 25-17 | |
| » Starters: Camilo Pascual vs Wynn Hawkins | Second | 2½ out |
| » Defeated Twins (19-24), 7-5 | Cleveland Stadium (11-9) | 26-17 | Won 2 |
| » Starters: Pedro Ramos vs Mudcat Grant | Second | 2½ out |
| Friday, June 2 |
| » Defeated Angels (16-27), 6-4 | Cleveland Stadium (12-9) | 27-17 | Won 3 |
| » Starters: Ken McBride vs Gary Bell | Second | 2 out |
| Saturday, June 3 |
| » Defeated Angels (16-28), 9-4 | Cleveland Stadium (13-9) | 28-17 | Won 4 |
| » Starters: Art Fowler vs Mudcat Grant | Second | 2 out |
| Sunday, June 4 |
| » Defeated Angels (16-29), 5-3 | Cleveland Stadium (14-9) | 29-17 | Won 5 |
| » Starters: Ron Kline vs Jim Perry | Second | 2 out |
| » Defeated Angels (16-30), 8-4 | Cleveland Stadium (15-9) | 30-17 | Won 6 |
| » Starters: Jerry Casale vs Wynn Hawkins | Second | 2 out |
| Monday, June 5 |
| » Defeated Senators (24-26), 7-5 | Griffith Stadium (3-1) | 31-17 | Won 7 |
| » Starters: Johnny Antonelli vs Tom Sturdivant | Second | 1 out |
| Former Indian Syd Smith dies in Orangeburg, SC at the age of 78. |
| Tuesday, June 6 |
| » Defeated Senators (24-27), 14-3 | Griffith Stadium (4-1) | 32-17 | Won 8 |
| » Starters: Gary Bell vs Joe McClain | First | -- |
| Wednesday, June 7 |
| » Defeated Senators (24-28), 11-0 | Griffith Stadium (5-1) | 33-17 | Won 9 |
| » Starters: Mudcat Grant vs Pete Burnside | First | -- |
| Thursday, June 8 |
| » Defeated Tigers (33-19), 1-0 | Tiger Stadium (2-0) | 34-17 | Won 10 |
| » Starters: Jim Perry vs Don Mossi | First | -- |
| » Lost to Tigers (34-19), 2-1 | Tiger Stadium (2-1) | 34-18 | |
| » Starters: Wynn Hawkins vs Frank Lary | First | -- |
| Friday, June 9 |
| » Defeated Tigers (34-20), 5-4 | Tiger Stadium (3-1) | 35-18 | |
| » Starters: Bobby Locke vs Phil Regan | First | -- |
| Saturday, June 10 |
| » Lost to Tigers (35-20), 2-0 | Tiger Stadium (3-2) | 35-19 | |
| » Starters: Gary Bell vs Jim Bunning | First | -- |
| Sunday, June 11 |
| » Defeated Athletics (23-28), 7-3 | Cleveland Stadium (16-9) | 36-19 | |
| » Starters: Jerry Walker vs Johnny Antonelli | First | -- |
| » Defeated Athletics (23-29), 4-3 | Cleveland Stadium (17-9) | 37-19 | Won 2 |
| » Starters: Ed Rakow vs Mudcat Grant | First | -- |
| Monday, June 12 |
| » Lost to Athletics (24-29), 7-5 | Cleveland Stadium (17-10) | 37-20 | |
| » Starters: Bob Shaw vs Wynn Hawkins | First | -- |
| Tuesday, June 13 |
| » Defeated Yankees (35-21), 7-2 | Cleveland Stadium (18-10) | 38-20 | |
| » Starters: Jim Coates vs Jim Perry | First | -- |
| Wednesday, June 14 |
| » Lost to Yankees (36-21), 11-5 | Cleveland Stadium (18-11) | 38-21 | |
| » Starters: Whitey Ford vs Gary Bell | First | -- |
| Thursday, June 15 |
| » Lost to Yankees (37-21), 3-2 | Cleveland Stadium (18-12) | 38-22 | Lost 2 |
| » Starters: Ralph Terry vs Mudcat Grant | Second | 1 out |
| Friday, June 16 |
| » Defeated Orioles (30-31), 3-1 | Cleveland Stadium (19-12) | 39-22 | |
| » Starters: Chuck Estrada vs Dick Stigman | First | -- |
| Saturday, June 17 |
| » Lost to Orioles (31-31), 4-1 | Cleveland Stadium (19-13) | 39-23 | |
| » Starters: Milt Pappas vs Wynn Hawkins | Second | 1 out |
| Sunday, June 18 |
| » Defeated Orioles (31-32), 2-1 | Cleveland Stadium (20-13) | 40-23 | |
| » Starters: Steve Barber vs Jim Perry | Second | ½ out |
| » Lost to Orioles (32-32), 8-5 | Cleveland Stadium (20-14) | 40-24 | |
| » Starters: Jack Fisher vs Gary Bell | Second | ½ out |
| Tuesday, June 20 |
| » Lost to White Sox (30-34), 5-3 | Comiskey Park I (1-2) | 40-25 | Lost 2 |
| » Starters: Mudcat Grant vs Billy Pierce | Third | 1½ out |
| Wednesday, June 21 |
| » Lost to White Sox (31-34), 15-3 | Comiskey Park I (1-3) | 40-26 | Lost 3 |
| » Starters: Gary Bell vs Frank Baumann | Third | 2½ out |
| » Lost to White Sox (32-34), 11-1 | Comiskey Park I (1-4) | 40-27 | Lost 4 |
| » Starters: Wynn Hawkins vs Juan Pizarro | Third | 2½ out |
| Friday, June 23 |
| » Lost to Tigers (43-23), 15-7 | Cleveland Stadium (20-15) | 40-28 | Lost 5 |
| » Starters: Don Mossi vs Jim Perry | Third | 4 out |
| Saturday, June 24 |
| » Lost to Tigers (44-23), 5-4 | Cleveland Stadium (20-16) | 40-29 | Lost 6 |
| » Starters: Frank Lary vs Mudcat Grant | Third | 5 out |
| Sunday, June 25 |
| » Lost to Tigers (45-23), 6-3 | Cleveland Stadium (20-17) | 40-30 | Lost 7 |
| » Starters: Jim Bunning vs Wynn Hawkins | Third | 5 out |
| » Defeated Tigers (45-24), 4-3 | Cleveland Stadium (21-17) | 41-30 | |
| » Starters: Bob Bruce vs Gary Bell | Third | 5 out |
| Tuesday, June 27 |
| » Lost to Senators (31-40), 8-5 | Cleveland Stadium (21-18) | 41-31 | |
| » Starters: Ed Hobaugh vs Dick Stigman | Third | 4½ out |
| Wednesday, June 28 |
| » Defeated Senators (31-41), 3-2 | Cleveland Stadium (22-18) | 42-31 | |
| » Starters: Joe McClain vs Jim Perry | Third | 5 out |
| » Lost to Senators (32-41), 5-2 | Cleveland Stadium (22-19) | 42-32 | |
| » Starters: Bennie Daniels vs Mudcat Grant | Third | 5 out |
| Thursday, June 29 |
| » Lost to Senators (33-41), 3-1 | Cleveland Stadium (22-20) | 42-33 | Lost 2 |
| » Starters: Gabe Gabler vs Wynn Hawkins | Third | 6 out |
| Friday, June 30 |
| » Defeated Red Sox (38-36), 10-2 | Fenway Park (3-1) | 43-33 | |
| » Starters: Gary Bell vs Billy Muffett | Third | 6 out |
| » Major-league debuts: Wilbur Wood (Red Sox) |
| Saturday, July 1 |
| » Defeated Red Sox (38-37), 7-3 | Fenway Park (4-1) | 44-33 | Won 2 |
| » Starters: Barry Latman vs Galen Cisco | Third | 6 out |
| Sunday, July 2 |
| » Defeated Red Sox (38-38), 12-6 | Fenway Park (5-1) | 45-33 | Won 3 |
| » Starters: Mudcat Grant vs Gene Conley | Third | 5 out |
| Monday, July 3 |
| » Lost to Orioles (42-36), 5-0 | Memorial Stadium (2-2) | 45-34 | |
| » Starters: Jim Perry vs Milt Pappas | Third | 5½ out |
| Tuesday, July 4 |
| » Lost to Orioles (43-36), 5-1 | Memorial Stadium (2-3) | 45-35 | Lost 2 |
| » Starters: Wynn Hawkins vs Steve Barber | Third | 6 out |
| Wednesday, July 5 |
| » Lost to Yankees (49-28), 6-0 | Yankee Stadium (0-3) | 45-36 | Lost 3 |
| » Starters: Gary Bell vs Rollie Sheldon | Third | 6½ out |
| Thursday, July 6 |
| » Lost to Yankees (50-28), 4-0 | Yankee Stadium (0-4) | 45-37 | Lost 4 |
| » Starters: Dick Stigman vs Bill Stafford | Third | 7½ out |
| Friday, July 7 |
| » Defeated White Sox (40-43), 9-0 | Cleveland Stadium (23-20) | 46-37 | |
| » Starters: Ray Herbert vs Barry Latman | Third | 7 out |
| Saturday, July 8 |
| » Defeated White Sox (40-44), 3-2 | Cleveland Stadium (24-20) | 47-37 | Won 2 |
| » Starters: Juan Pizarro vs Mudcat Grant | Third | 7 out |
| Sunday, July 9 |
| » Lost to White Sox (41-44), 7-5 | Cleveland Stadium (24-21) | 47-38 | |
| » Starters: Billy Pierce vs Wynn Hawkins | Fourth | 8½ out |
| » Lost to White Sox (42-44), 9-8 | Cleveland Stadium (24-22) | 47-39 | Lost 2 |
| » Starters: Cal McLish vs Jim Perry | Fourth | 8½ out |
| Thursday, July 13 |
| » Lost to Twins (35-50), 9-6 | Cleveland Stadium (24-23) | 47-40 | Lost 3 |
| » Starters: Pedro Ramos vs Mudcat Grant | Fourth | 9 out |
| Friday, July 14 |
| » Defeated Angels (35-52), 7-5 | Cleveland Stadium (25-23) | 48-40 | |
| » Starters: Ken McBride vs Barry Latman | Fourth | 8 out |
| Saturday, July 15 |
| » Lost to Angels (36-52), 6-5 | Cleveland Stadium (25-24) | 48-41 | |
| » Starters: Eli Grba vs Jim Perry | Fourth | 9 out |
| Sunday, July 16 |
| » Defeated Twins (36-52), 7-5 | Cleveland Stadium (26-24) | 49-41 | |
| » Starters: Jim Kaat vs Gary Bell | Fourth | 10 out |
| » Lost to Twins (37-52), 12-5 | Cleveland Stadium (26-25) | 49-42 | |
| » Starters: Bert Cueto vs Wynn Hawkins | Fourth | 10 out |
| Tuesday, July 18 |
| » Lost to Red Sox (44-48), 9-2 | Cleveland Stadium (26-26) | 49-43 | Lost 2 |
| » Starters: Don Schwall vs Mudcat Grant | Fourth | 11 out |
| Wednesday, July 19 |
| » Defeated Red Sox (44-49), 4-1 | Cleveland Stadium (27-26) | 50-43 | |
| » Starters: Gene Conley vs Barry Latman | Fourth | 9 out |
| » Defeated Red Sox (44-50), 9-8 | Cleveland Stadium (28-26) | 51-43 | Won 2 |
| » Starters: Wilbur Wood vs Jim Perry | Fourth | 9 out |
| Thursday, July 20 |
| » Defeated Red Sox (44-51), 12-11 | Cleveland Stadium (29-26) | 52-43 | Won 3 |
| » Starters: Ike Delock vs Gary Bell | Fourth | 9 out |
| Friday, July 21 |
| » Lost to Twins (39-54), 4-3 | Metropolitan Stadium (3-1) | 52-44 | |
| » Starters: Wynn Hawkins vs Don Lee | Fourth | 9½ out |
| Saturday, July 22 |
| » Defeated Twins (39-55), 4-0 | Metropolitan Stadium (4-1) | 53-44 | |
| » Starters: Mudcat Grant vs Jim Kaat | Third | 9½ out |
| Sunday, July 23 |
| » Lost to Twins (40-55), 10-0 | Metropolitan Stadium (4-2) | 53-45 | |
| » Starters: Barry Latman vs Pedro Ramos | Third | 10 out |
| Tuesday, July 25 |
| » Lost to Athletics (35-60), 3-2 | Municipal Stadium (2-2) | 53-46 | Lost 2 |
| » Starters: Jim Perry vs Jerry Walker | Fourth | 11 out |
| Wednesday, July 26 |
| » Defeated Athletics (35-61), 12-5 | Municipal Stadium (3-2) | 54-46 | |
| » Starters: Gary Bell vs Jim Archer | Fourth | 11 out |
| Thursday, July 27 |
| » Lost to Athletics (36-61), 2-1 | Municipal Stadium (3-3) | 54-47 | |
| » Starters: Mudcat Grant vs Art Ditmar | Fourth | 12 out |
| Friday, July 28 |
| » Lost to Angels (44-56), 8-5 | Wrigley Field (2-2) | 54-48 | Lost 2 |
| » Starters: Barry Latman vs Jim Donohue | Fourth | 12 out |
| Saturday, July 29 |
| » Defeated Angels (44-57), 8-3 | Wrigley Field (3-2) | 55-48 | |
| » Starters: Jim Perry vs Ken McBride | Fourth | 12 out |
| Sunday, July 30 |
| » Lost to Angels (45-57), 8-6 | Wrigley Field (3-3) | 55-49 | |
| » Starters: Gary Bell vs Ted Bowsfield | Fourth | 11½ out |
| Wednesday, August 2 |
| » Defeated White Sox (51-54), 3-2 | Cleveland Stadium (30-26) | 56-49 | |
| » Starters: Ray Herbert vs Mudcat Grant | Fourth | 12½ out |
| » Lost to White Sox (52-54), 8-4 | Cleveland Stadium (30-27) | 56-50 | |
| » Starters: Cal McLish vs Jim Perry | Fourth | 12½ out |
| Future Indian Danny Sheaffer is born in Jacksonville, FL. |
| Thursday, August 3 |
| » Lost to White Sox (53-54), 8-6 | Cleveland Stadium (30-28) | 56-51 | Lost 2 |
| » Starters: Frank Baumann vs Wynn Hawkins | Fourth | 12½ out |
| Friday, August 4 |
| » Lost to Tigers (67-39), 6-1 | Tiger Stadium (3-3) | 56-52 | Lost 3 |
| » Starters: Barry Latman vs Frank Lary | Fourth | 13½ out |
| Saturday, August 5 |
| » Lost to Tigers (68-39), 7-6 | Tiger Stadium (3-4) | 56-53 | Lost 4 |
| » Starters: Gary Bell vs Phil Regan | Fourth | 14½ out |
| Sunday, August 6 |
| » Lost to Tigers (69-39), 2-1 | Tiger Stadium (3-5) | 56-54 | Lost 5 |
| » Starters: Jim Perry vs Don Mossi | Fourth | 15½ out |
| » Defeated Tigers (69-40), 9-5 | Tiger Stadium (4-5) | 57-54 | |
| » Starters: Mudcat Grant vs Paul Foytack | Fourth | 15½ out |
| Tuesday, August 8 |
| » Defeated Senators (46-62), 6-5 | Cleveland Stadium (31-28) | 58-54 | Won 2 |
| » Starters: Bennie Daniels vs Barry Latman | Fourth | 16 out |
| Wednesday, August 9 |
| » Defeated Senators (46-63), 3-1 | Cleveland Stadium (32-28) | 59-54 | Won 3 |
| » Starters: Gabe Gabler vs Gary Bell | Fourth | 16 out |
| Friday, August 11 |
| » Defeated Angels (47-66), 3-2 | Cleveland Stadium (33-28) | 60-54 | Won 4 |
| » Starters: Ken McBride vs Jim Perry | Fourth | 16½ out |
| Saturday, August 12 |
| » Lost to Angels (48-66), 3-0 | Cleveland Stadium (33-29) | 60-55 | |
| » Starters: Ryne Duren vs Mudcat Grant | Fourth | 16½ out |
| Sunday, August 13 |
| » Lost to Angels (49-66), 8-7 | Cleveland Stadium (33-30) | 60-56 | Lost 2 |
| » Starters: Eli Grba vs Barry Latman | Fourth | 17 out |
| Tuesday, August 15 |
| » Lost to Red Sox (57-64), 8-0 | Cleveland Stadium (33-31) | 60-57 | Lost 3 |
| » Starters: Gene Conley vs Gary Bell | Fourth | 17 out |
| Wednesday, August 16 |
| » Defeated Red Sox (57-65), 6-4 | Cleveland Stadium (34-31) | 61-57 | |
| » Starters: Tracy Stallard vs Jim Perry | Fourth | 17 out |
| Thursday, August 17 |
| » Defeated Red Sox (57-66), 4-3 | Cleveland Stadium (35-31) | 62-57 | Won 2 |
| » Starters: Ike Delock vs Wynn Hawkins | Fourth | 17 out |
| » Major-league debuts: Bill Dailey (Indians) |
| Friday, August 18 |
| » Defeated Yankees (79-41), 5-1 | Cleveland Stadium (36-31) | 63-57 | Won 3 |
| » Starters: Jim Coates vs Mudcat Grant | Fourth | 16 out |
| Saturday, August 19 |
| » Lost to Yankees (80-41), 3-2 | Cleveland Stadium (36-32) | 63-58 | |
| » Starters: Whitey Ford vs Barry Latman | Fourth | 17 out |
| Sunday, August 20 |
| » Lost to Yankees (81-41), 6-0 | Cleveland Stadium (36-33) | 63-59 | Lost 2 |
| » Starters: Ralph Terry vs Jim Perry | Fourth | 19 out |
| » Lost to Yankees (82-41), 5-2 | Cleveland Stadium (36-34) | 63-60 | Lost 3 |
| » Starters: Rollie Sheldon vs Gary Bell | Fourth | 19 out |
| Tuesday, August 22 |
| » Lost to Tigers (80-44), 8-1 | Cleveland Stadium (36-35) | 63-61 | Lost 4 |
| » Starters: Paul Foytack vs Mudcat Grant | Fifth | 19 out |
| Wednesday, August 23 |
| » Defeated Tigers (80-45), 4-2 | Cleveland Stadium (37-35) | 64-61 | |
| » Starters: Don Mossi vs Barry Latman | Fourth | 19 out |
| Thursday, August 24 |
| » Lost to Tigers (81-45), 6-0 | Cleveland Stadium (37-36) | 64-62 | |
| » Starters: Frank Lary vs Jim Perry | Fourth | 19 out |
| Friday, August 25 |
| » Lost to White Sox (65-62), 3-2 | Comiskey Park I (1-5) | 64-63 | Lost 2 |
| » Starters: Gary Bell vs Juan Pizarro | Fifth | 20 out |
| Saturday, August 26 |
| » Lost to White Sox (66-62), 10-5 | Comiskey Park I (1-6) | 64-64 | Lost 3 |
| » Starters: Wynn Hawkins vs Frank Baumann | Fifth | 21 out |
| Sunday, August 27 |
| » Lost to White Sox (67-62), 10-6 | Comiskey Park I (1-7) | 64-65 | Lost 4 |
| » Starters: Mudcat Grant vs Billy Pierce | Fifth | 22½ out |
| » Lost to White Sox (68-62), 9-3 | Comiskey Park I (1-8) | 64-66 | Lost 5 |
| » Starters: Barry Latman vs Cal McLish | Fifth | 22½ out |
| Tuesday, August 29 |
| » Defeated Senators (50-78), 6-4 | Griffith Stadium (6-1) | 65-66 | |
| » Starters: Jim Perry vs Dick Donovan | Fifth | 21½ out |
| Wednesday, August 30 |
| » Defeated Senators (50-79), 9-0 | Griffith Stadium (7-1) | 66-66 | Won 2 |
| » Starters: Gary Bell vs Gabe Gabler | Fifth | 21½ out |
| Thursday, August 31 |
| » Defeated Senators (50-80), 3-2 | Griffith Stadium (8-1) | 67-66 | Won 3 |
| » Starters: Mudcat Grant vs Bennie Daniels | Fifth | 20½ out |
| Friday, September 1 |
| » Defeated Orioles (78-58), 5-4 | Memorial Stadium (3-3) | 68-66 | Won 4 |
| » Starters: Barry Latman vs Chuck Estrada | Fifth | 20½ out |
| Saturday, September 2 |
| » Lost to Orioles (79-58), 3-2 | Memorial Stadium (3-4) | 68-67 | |
| » Starters: Dick Stigman vs Milt Pappas | Fifth | 21 out |
| » Defeated Orioles (79-59), 6-0 | Memorial Stadium (4-4) | 69-67 | |
| » Starters: Jim Perry vs Hal Brown | Fifth | 21 out |
| Sunday, September 3 |
| » Lost to Orioles (80-59), 1-0 | Memorial Stadium (4-5) | 69-68 | |
| » Starters: Gary Bell vs Steve Barber | Fifth | 22 out |
| Monday, September 4 |
| » Defeated Red Sox (66-74), 7-2 | Fenway Park (6-1) | 70-68 | |
| » Starters: Mudcat Grant vs Ike Delock | Fifth | 22½ out |
| Tuesday, September 5 |
| » Defeated Red Sox (66-75), 9-5 | Fenway Park (7-1) | 71-68 | Won 2 |
| » Starters: Barry Latman vs Gene Conley | Fifth | 22½ out |
| Wednesday, September 6 |
| » Lost to Red Sox (67-75), 9-4 | Fenway Park (7-2) | 71-69 | |
| » Starters: Jim Perry vs Don Schwall | Fifth | 23½ out |
| Future Indian Roy Smith is born in Mount Vernon, NY. |
| Thursday, September 7 |
| » Lost to Yankees (95-45), 7-3 | Yankee Stadium (0-5) | 71-70 | Lost 2 |
| » Starters: Dick Stigman vs Ralph Terry | Fifth | 24½ out |
| Friday, September 8 |
| » Lost to Yankees (96-45), 9-1 | Yankee Stadium (0-6) | 71-71 | Lost 3 |
| » Starters: Gary Bell vs Bill Stafford | Fifth | 25½ out |
| Saturday, September 9 |
| » Lost to Yankees (97-45), 8-7 | Yankee Stadium (0-7) | 71-72 | Lost 4 |
| » Starters: Mudcat Grant vs Rollie Sheldon | Fifth | 26½ out |
| Sunday, September 10 |
| » Lost to Yankees (98-45), 7-6 | Yankee Stadium (0-8) | 71-73 | Lost 5 |
| » Starters: Barry Latman vs Whitey Ford | Fifth | 28½ out |
| » Lost to Yankees (99-45), 9-3 | Yankee Stadium (0-9) | 71-74 | Lost 6 |
| » Starters: Jim Perry vs Bud Daley | Fifth | 28½ out |
| Wednesday, September 13 |
| » Defeated Orioles (87-61), 5-0 | Cleveland Stadium (38-36) | 72-74 | |
| » Starters: Steve Barber vs Gary Bell | Fifth | 28½ out |
| Friday, September 15 |
| » Lost to Twins (64-82), 3-2 | Cleveland Stadium (38-37) | 72-75 | |
| » Starters: Jack Kralick vs Sam McDowell | Fifth | 28 out |
| » Major-league debuts: Sam McDowell (Indians) Jim Snyder (Twins) |
| Saturday, September 16 |
| » Defeated Twins (64-83), 2-0 | Cleveland Stadium (39-37) | 73-75 | |
| » Starters: Pedro Ramos vs Barry Latman | Fifth | 27 out |
| » Major-league debuts: Al Luplow (Indians) |
| Sunday, September 17 |
| » Lost to Twins (65-83), 5-0 | Cleveland Stadium (39-38) | 73-76 | |
| » Starters: Camilo Pascual vs Jim Perry | Fifth | 28½ out |
| » Lost to Twins (66-83), 5-3 | Cleveland Stadium (39-39) | 73-77 | Lost 2 |
| » Starters: Al Schroll vs Mudcat Grant | Fifth | 28½ out |
| Tuesday, September 19 |
| » Lost to Athletics (56-94), 6-0 | Cleveland Stadium (39-40) | 73-78 | Lost 3 |
| » Starters: Jim Archer vs Dick Stigman | Fifth | 28½ out |
| » Defeated Athletics (56-95), 6-2 | Cleveland Stadium (40-40) | 74-78 | |
| » Starters: Bob Shaw vs Gary Bell | Fifth | 28½ out |
| Wednesday, September 20 |
| » Lost to Athletics (57-95), 4-2 | Cleveland Stadium (40-41) | 74-79 | |
| » Starters: Norm Bass vs Barry Latman | Fifth | 29½ out |
| Friday, September 22 |
| » Lost to Athletics (58-95), 4-3 | Municipal Stadium (3-4) | 74-80 | Lost 2 |
| » Starters: Jim Perry vs Jerry Walker | Fifth | 29½ out |
| Saturday, September 23 |
| » Defeated Athletics (58-96), 9-5 | Municipal Stadium (4-4) | 75-80 | |
| » Starters: Mudcat Grant vs Bill Kirk | Fifth | 29½ out |
| Tuesday, September 26 |
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