| Tuesday, January 17 |
| Former Cardinal Bud Tinning dies in Evansville, IN at the age of 55. |
| Wednesday, January 18 |
| Former Cardinal Gene Woodburn dies in Sandusky, OH at the age of 75. |
| Thursday, February 16 |
| Former Cardinal Dazzy Vance dies in Homosassa Springs, FL at the age of 70. |
| Thursday, February 23 |
| Future Cardinal John Morris is born in North Bellmore, NY. |
| Wednesday, March 8 |
| Future Cardinal Mark Salas is born in Montebello, CA. |
| Tuesday, March 28 |
| Former Cardinal Jim Hackett dies in Douglas, MI at the age of 84. |
| Tuesday, April 11 |
| » Defeated Braves (0-1), 2-1 | County Stadium (1-0) | 1-0 | |
| » Starters: Ernie Broglio vs Warren Spahn | First | -- |
| Thursday, April 13 |
| » Lost to Braves (1-1), 5-4 | County Stadium (1-1) | 1-1 | |
| » Starters: Bob Miller vs Lew Burdette | Third | 1 out |
| Friday, April 14 |
| » Lost to Reds (3-0), 7-3 | Sportsman's Park III (0-1) | 1-2 | Lost 2 |
| » Starters: Jay Hook vs Curt Simmons | Fourth | 2 out |
| » Major-league debuts: Jerry Zimmerman (Reds) |
| Saturday, April 15 |
| » Defeated Reds (3-1), 4-0 | Sportsman's Park III (1-1) | 2-2 | |
| » Starters: Joey Jay vs Ernie Broglio | Third | 1 out |
| Sunday, April 16 |
| » Defeated Reds (3-2), 5-3 | Sportsman's Park III (2-1) | 3-2 | Won 2 |
| » Starters: Jim O'Toole vs Ray Sadecki | Second | ½ out |
| » Major-league debuts: Ken Hunt (Reds) |
| Monday, April 17 |
| » Defeated Dodgers (3-4), 9-5 | Los Angeles Memorial Coliseum (1-0) | 4-2 | Won 3 |
| » Starters: Bob Gibson vs Johnny Podres | First | -- |
| Tuesday, April 18 |
| » Lost to Dodgers (4-4), 5-4 | Los Angeles Memorial Coliseum (1-1) | 4-3 | |
| » Starters: Al Cicotte vs Roger Craig | Second | ½ out |
| Wednesday, April 19 |
| » Lost to Dodgers (5-4), 7-2 | Los Angeles Memorial Coliseum (1-2) | 4-4 | Lost 2 |
| » Starters: Ernie Broglio vs Don Drysdale | Fourth | 1½ out |
| Thursday, April 20 |
| » Defeated Dodgers (5-5), 11-2 | Los Angeles Memorial Coliseum (2-2) | 5-4 | |
| » Starters: Curt Simmons vs Stan Williams | Second | ½ out |
| Saturday, April 22 |
| » Major-league debuts: Jack Curtis (Cubs) |
| Sunday, April 23 |
| » Lost to Giants (6-4), 2-1 | Candlestick Park (0-1) | 5-5 | |
| » Starters: Ernie Broglio vs Sam Jones | Second | 1 out |
| » Defeated Giants (6-5), 7-4 | Candlestick Park (1-1) | 6-5 | |
| » Starters: Bob Gibson vs Billy Loes | Second | 1 out |
| Tuesday, April 25 |
| » Lost to Braves (4-4), 4-3 | Sportsman's Park III (2-2) | 6-6 | |
| » Starters: Lew Burdette vs Curt Simmons | Fifth | 1 out |
| Wednesday, April 26 |
| » Lost to Braves (5-4), 8-1 | Sportsman's Park III (2-3) | 6-7 | Lost 2 |
| » Starters: Don Nottebart vs Larry Jackson | Sixth | 2 out |
| Friday, April 28 |
| » Defeated Phillies (4-9), 10-9 | Sportsman's Park III (3-3) | 7-7 | |
| » Starters: Robin Roberts vs Ernie Broglio | Sixth | 2 out |
| » Major-league debuts: Jack Baldschun (Phillies) |
| Saturday, April 29 |
| » Lost to Phillies (5-9), 3-2 | Sportsman's Park III (3-4) | 7-8 | |
| » Starters: Art Mahaffey vs Ray Sadecki | Sixth | 2 out |
| Sunday, April 30 |
| » Lost to Phillies (6-9), 11-7 | Sportsman's Park III (3-5) | 7-9 | Lost 2 |
| » Starters: Frank Sullivan vs Curt Simmons | Sixth | 3 out |
| Tuesday, May 2 |
| » Lost to Pirates (10-6), 6-0 | Sportsman's Park III (3-6) | 7-10 | Lost 3 |
| » Starters: Harvey Haddix vs Ernie Broglio | Seventh | 3½ out |
| Wednesday, May 3 |
| » Defeated Pirates (10-7), 3-1 | Sportsman's Park III (4-6) | 8-10 | |
| » Starters: Vinegar Bend Mizell vs Bob Gibson | Seventh | 3 out |
| Saturday, May 6 |
| » Defeated Cubs (9-11), 6-1 | Sportsman's Park III (5-6) | 9-10 | Won 2 |
| » Starters: Jim Brewer vs Ray Sadecki | Sixth | 3½ out |
| Sunday, May 7 |
| » Defeated Cubs (9-12), 4-2 | Sportsman's Park III (6-6) | 10-10 | Won 3 |
| » Starters: Don Cardwell vs Ernie Broglio | Fifth | 3½ out |
| Wednesday, May 10 |
| » Lost to Reds (14-10), 3-2 | Crosley Field (0-1) | 10-11 | |
| » Starters: Curt Simmons vs Joey Jay | Sixth | 4 out |
| Friday, May 12 |
| » Defeated Phillies (6-19), 5-1 | Shibe Park (1-0) | 11-11 | |
| » Starters: Ernie Broglio vs John Buzhardt | Sixth | 3 out |
| Saturday, May 13 |
| » Lost to Phillies (7-19), 3-1 | Shibe Park (1-1) | 11-12 | |
| » Starters: Ray Sadecki vs Art Mahaffey | Sixth | 4 out |
| Sunday, May 14 |
| » Lost to Phillies (8-19), 6-4 | Shibe Park (1-2) | 11-13 | Lost 2 |
| » Starters: Larry Jackson vs Dallas Green | Sixth | 5 out |
| Tuesday, May 16 |
| » Lost to Pirates (15-11), 2-1 | Forbes Field (0-1) | 11-14 | Lost 3 |
| » Starters: Curt Simmons vs Vern Law | Sixth | 6½ out |
| Wednesday, May 17 |
| » Lost to Pirates (16-11), 4-3 | Forbes Field (0-2) | 11-15 | Lost 4 |
| » Starters: Ernie Broglio vs Vinegar Bend Mizell | Sixth | 7½ out |
| Friday, May 19 |
| » Lost to Cubs (11-19), 1-0 | Wrigley Field (0-1) | 11-16 | Lost 5 |
| » Starters: Ray Sadecki vs Glen Hobbie | Sixth | 7½ out |
| Saturday, May 20 |
| » Lost to Cubs (12-19), 1-0 | Wrigley Field (0-2) | 11-17 | Lost 6 |
| » Starters: Larry Jackson vs Dick Ellsworth | Sixth | 7½ out |
| » Major-league debuts: Jimmie Schaffer (Cardinals) |
| Sunday, May 21 |
| » Defeated Cubs (12-20), 6-3 | Wrigley Field (1-2) | 12-17 | |
| » Starters: Curt Simmons vs Don Cardwell | Sixth | 6 out |
| » Defeated Cubs (12-21), 3-0 | Wrigley Field (2-2) | 13-17 | Won 2 |
| » Starters: Bob Gibson vs Dick Drott | Sixth | 6 out |
| Monday, May 22 |
| » Lost to Giants (21-12), 3-1 | Sportsman's Park III (6-7) | 13-18 | |
| » Starters: Jack Sanford vs Ernie Broglio | Sixth | 7 out |
| Tuesday, May 23 |
| » Defeated Giants (21-13), 12-4 | Sportsman's Park III (7-7) | 14-18 | |
| » Starters: Sam Jones vs Ray Sadecki | Sixth | 6 out |
| Wednesday, May 24 |
| » Defeated Dodgers (23-16), 7-2 | Sportsman's Park III (8-7) | 15-18 | Won 2 |
| » Starters: Roger Craig vs Larry Jackson | Sixth | 6 out |
| Thursday, May 25 |
| » Lost to Dodgers (24-16), 1-0 | Sportsman's Park III (8-8) | 15-19 | |
| » Starters: Sandy Koufax vs Bob Gibson | Sixth | 6½ out |
| Friday, May 26 |
| » Defeated Pirates (20-14), 12-2 | Sportsman's Park III (9-8) | 16-19 | |
| » Starters: Bob Friend vs Curt Simmons | Sixth | 6½ out |
| Saturday, May 27 |
| » Defeated Pirates (20-15), 7-5 | Sportsman's Park III (10-8) | 17-19 | Won 2 |
| » Starters: Vern Law vs Ernie Broglio | Sixth | 6½ out |
| Sunday, May 28 |
| » Defeated Pirates (20-16), 8-4 | Sportsman's Park III (11-8) | 18-19 | Won 3 |
| » Starters: Harvey Haddix vs Ray Sadecki | Sixth | 6½ out |
| Monday, May 29 |
| » Lost to Dodgers (26-18), 2-1 | Los Angeles Memorial Coliseum (2-3) | 18-20 | |
| » Starters: Larry Jackson vs Sandy Koufax | Sixth | 6½ out |
| Tuesday, May 30 |
| » Lost to Dodgers (27-18), 5-3 | Los Angeles Memorial Coliseum (2-4) | 18-21 | Lost 2 |
| » Starters: Bob Gibson vs Stan Williams | Fifth | 6 out |
| Wednesday, May 31 |
| » Lost to Giants (26-16), 3-2 | Candlestick Park (1-2) | 18-22 | Lost 3 |
| » Starters: Curt Simmons vs Billy O'Dell | Fifth | 7 out |
| Thursday, June 1 |
| » Defeated Giants (26-17), 7-6 | Candlestick Park (2-2) | 19-22 | |
| » Starters: Ernie Broglio vs Mike McCormick | Sixth | 6½ out |
| Friday, June 2 |
| » Defeated Braves (19-22), 3-1 | County Stadium (2-1) | 20-22 | Won 2 |
| » Starters: Ray Sadecki vs Carl Willey | Fifth | 5½ out |
| Saturday, June 3 |
| » Lost to Braves (20-22), 9-3 | County Stadium (2-2) | 20-23 | |
| » Starters: Larry Jackson vs Bob Buhl | Sixth | 6½ out |
| Sunday, June 4 |
| » Lost to Braves (21-22), 7-1 | County Stadium (2-3) | 20-24 | Lost 2 |
| » Starters: Bob Gibson vs Warren Spahn | Fifth | 6½ out |
| Monday, June 5 |
| » Defeated Cubs (19-28), 10-8 | Sportsman's Park III (12-8) | 21-24 | |
| » Starters: Dick Ellsworth vs Curt Simmons | Sixth | 6 out |
| Tuesday, June 6 |
| » Defeated Cubs (19-29), 6-2 | Sportsman's Park III (13-8) | 22-24 | Won 2 |
| » Starters: Glen Hobbie vs Ernie Broglio | Fifth | 6 out |
| » Tied Cubs, 3-3 | Sportsman's Park III (13-8) | 22-24 | |
| » Starters: Jack Curtis vs Ray Sadecki | Fifth | 6 out |
| Wednesday, June 7 |
| » Defeated Cubs (19-30), 8-6 | Sportsman's Park III (14-8) | 23-24 | Won 3 |
| » Starters: Bob Anderson vs Larry Jackson | Fifth | 5½ out |
| Friday, June 9 |
| » Defeated Reds (30-21), 8-4 | Sportsman's Park III (15-8) | 24-24 | Won 4 |
| » Starters: Jim O'Toole vs Bob Gibson | Fifth | 5 out |
| Saturday, June 10 |
| » Lost to Reds (31-21), 4-2 | Sportsman's Park III (15-9) | 24-25 | |
| » Starters: Joey Jay vs Curt Simmons | Fifth | 6 out |
| Sunday, June 11 |
| » Lost to Reds (32-21), 6-2 | Sportsman's Park III (15-10) | 24-26 | Lost 2 |
| » Starters: Ken Hunt vs Ray Sadecki | Fifth | 7½ out |
| » Lost to Reds (33-21), 9-3 | Sportsman's Park III (15-11) | 24-27 | Lost 3 |
| » Starters: Bob Purkey vs Ernie Broglio | Fifth | 7½ out |
| Tuesday, June 13 |
| » Lost to Phillies (18-33), 3-2 | Shibe Park (1-3) | 24-28 | Lost 4 |
| » Starters: Larry Jackson vs Don Ferrarese | Sixth | 7½ out |
| Thursday, June 15 |
| » Defeated Phillies (18-34), 6-3 | Shibe Park (2-3) | 25-28 | |
| » Starters: Ray Sadecki vs Art Mahaffey | Fourth | 7½ out |
| Friday, June 16 |
| » Defeated Pirates (28-26), 5-2 | Forbes Field (1-2) | 26-28 | Won 2 |
| » Starters: Bob Gibson vs Harvey Haddix | Fifth | 7 out |
| Saturday, June 17 |
| » Lost to Pirates (29-26), 9-3 | Forbes Field (1-3) | 26-29 | |
| » Starters: Ernie Broglio vs Bobby Shantz | Fifth | 8 out |
| Sunday, June 18 |
| » Lost to Pirates (30-26), 5-3 | Forbes Field (1-4) | 26-30 | Lost 2 |
| » Starters: Curt Simmons vs Bob Friend | Fifth | 9 out |
| » Defeated Pirates (30-27), 7-3 | Forbes Field (2-4) | 27-30 | |
| » Starters: Larry Jackson vs Joe Gibbon | Fifth | 9 out |
| Future Cardinal Andres Galarraga is born in Caracas, Venezuela. |
| Tuesday, June 20 |
| » Lost to Reds (39-23), 4-3 | Crosley Field (0-2) | 27-31 | |
| » Starters: Ray Sadecki vs Jay Hook | Fifth | 9 out |
| » Defeated Reds (39-24), 6-3 | Crosley Field (1-2) | 28-31 | |
| » Starters: Bob Gibson vs Joey Jay | Fifth | 9 out |
| Wednesday, June 21 |
| » Lost to Reds (40-24), 9-2 | Crosley Field (1-3) | 28-32 | |
| » Starters: Ernie Broglio vs Ken Hunt | Sixth | 10 out |
| Thursday, June 22 |
| » Lost to Reds (41-24), 7-5 | Crosley Field (1-4) | 28-33 | Lost 2 |
| » Starters: Larry Jackson vs Bob Purkey | Sixth | 11 out |
| Friday, June 23 |
| » Defeated Giants (36-28), 10-5 | Sportsman's Park III (16-11) | 29-33 | |
| » Starters: Billy O'Dell vs Curt Simmons | Sixth | 11 out |
| » Major-league debuts: Craig Anderson (Cardinals) |
| Saturday, June 24 |
| » Lost to Giants (37-28), 6-1 | Sportsman's Park III (16-12) | 29-34 | |
| » Starters: Dick LeMay vs Bob Gibson | Sixth | 11 out |
| Sunday, June 25 |
| » Lost to Giants (38-28), 6-4 | Sportsman's Park III (16-13) | 29-35 | Lost 2 |
| » Starters: Mike McCormick vs Bob Miller | Sixth | 11½ out |
| » Defeated Giants (38-29), 3-1 | Sportsman's Park III (17-13) | 30-35 | |
| » Starters: Billy Loes vs Ray Sadecki | Sixth | 11½ out |
| Monday, June 26 |
| » Lost to Braves (31-32), 9-6 | Sportsman's Park III (17-14) | 30-36 | |
| » Starters: Lew Burdette vs Larry Jackson | Sixth | 12 out |
| Tuesday, June 27 |
| » Lost to Braves (32-32), 3-0 | Sportsman's Park III (17-15) | 30-37 | Lost 2 |
| » Starters: Bob Buhl vs Curt Simmons | Sixth | 13 out |
| Wednesday, June 28 |
| » Lost to Braves (33-32), 8-3 | Sportsman's Park III (17-16) | 30-38 | Lost 3 |
| » Starters: Bob Hendley vs Bob Gibson | Sixth | 12½ out |
| Friday, June 30 |
| » Defeated Cubs (28-42), 11-4 | Wrigley Field (3-2) | 31-38 | |
| » Starters: Ray Sadecki vs Jim Brewer | Sixth | 12 out |
| » Major-league debuts: Jerry Buchek (Cardinals) |
| Saturday, July 1 |
| » Lost to Cubs (29-42), 13-1 | Wrigley Field (3-3) | 31-39 | |
| » Starters: Bob Miller vs Dick Ellsworth | Sixth | 12 out |
| Sunday, July 2 |
| » Lost to Cubs (30-42), 10-9 | Wrigley Field (3-4) | 31-40 | Lost 2 |
| » Starters: Al Cicotte vs Glen Hobbie | Sixth | 13½ out |
| Tuesday, July 4 |
| » Defeated Phillies (22-48), 10-7 | Sportsman's Park III (18-16) | 32-40 | |
| » Starters: Don Ferrarese vs Curt Simmons | Sixth | 14½ out |
| » Lost to Phillies (23-48), 10-6 | Sportsman's Park III (18-17) | 32-41 | |
| » Starters: Chris Short vs Ray Sadecki | Sixth | 14½ out |
| Wednesday, July 5 |
| » Defeated Dodgers (47-32), 9-1 | Los Angeles Memorial Coliseum (3-4) | 33-41 | |
| » Starters: Bob Gibson vs Johnny Podres | Sixth | 14½ out |
| Thursday, July 6 |
| » Lost to Dodgers (48-32), 10-1 | Los Angeles Memorial Coliseum (3-5) | 33-42 | |
| » Manager: Johnny Keane |
| » Starters: Bob Miller vs Don Drysdale | Sixth | 15½ out |
| Friday, July 7 |
| » Defeated Giants (43-37), 3-2 | Candlestick Park (3-2) | 34-42 | |
| » Starters: Al Cicotte vs Billy Loes | Sixth | 16 out |
| Saturday, July 8 |
| » Defeated Giants (43-38), 9-7 | Candlestick Park (4-2) | 35-42 | Won 2 |
| » Starters: Larry Jackson vs Dick LeMay | Sixth | 15 out |
| Sunday, July 9 |
| » Defeated Giants (43-39), 6-3 | Candlestick Park (5-2) | 36-42 | Won 3 |
| » Starters: Curt Simmons vs Billy O'Dell | Sixth | 15½ out |
| » Lost to Giants (44-39), 6-1 | Candlestick Park (5-3) | 36-43 | |
| » Starters: Ray Sadecki vs Jack Sanford | Sixth | 15½ out |
| Thursday, July 13 |
| » Lost to Braves (38-40), 6-3 | Sportsman's Park III (18-18) | 36-44 | Lost 2 |
| » Starters: Tony Cloninger vs Bob Gibson | Sixth | 16½ out |
| » Major-league debuts: Mack Jones (Braves) |
| Friday, July 14 |
| » Defeated Braves (38-41), 2-1 | Sportsman's Park III (19-18) | 37-44 | |
| » Starters: Bob Buhl vs Larry Jackson | Sixth | 15½ out |
| Saturday, July 15 |
| » Defeated Braves (38-42), 12-4 | Sportsman's Park III (20-18) | 38-44 | Won 2 |
| » Starters: Lew Burdette vs Ray Sadecki | Sixth | 15½ out |
| Sunday, July 16 |
| » Lost to Braves (39-42), 9-1 | Sportsman's Park III (20-19) | 38-45 | |
| » Starters: Bob Hendley vs Al Cicotte | Sixth | 15½ out |
| Monday, July 17 |
| » Defeated Cubs (38-47), 10-6 | Sportsman's Park III (21-19) | 39-45 | |
| » Starters: Don Cardwell vs Curt Simmons | Sixth | 14 out |
| » Defeated Cubs (38-48), 8-5 | Sportsman's Park III (22-19) | 40-45 | Won 2 |
| » Starters: Jim Brewer vs Ernie Broglio | Sixth | 14 out |
| Tuesday, July 18 |
| » Defeated Cubs (38-49), 8-3 | Sportsman's Park III (23-19) | 41-45 | Won 3 |
| » Starters: Glen Hobbie vs Larry Jackson | Sixth | 12½ out |
| » Defeated Cubs (38-50), 7-5 | Sportsman's Park III (24-19) | 42-45 | Won 4 |
| » Starters: Dick Drott vs Bob Gibson | Sixth | 12½ out |
| Wednesday, July 19 |
| » Defeated Giants (47-42), 3-2 | Sportsman's Park III (25-19) | 43-45 | Won 5 |
| » Starters: Mike McCormick vs Ray Sadecki | Sixth | 11½ out |
| Thursday, July 20 |
| » Lost to Giants (48-42), 10-6 | Sportsman's Park III (25-20) | 43-46 | |
| » Starters: Sam Jones vs Al Cicotte | Sixth | 11½ out |
| Friday, July 21 |
| » Defeated Dodgers (54-38), 10-1 | Sportsman's Park III (26-20) | 44-46 | |
| » Starters: Don Drysdale vs Curt Simmons | Sixth | 11 out |
| Saturday, July 22 |
| » Lost to Dodgers (55-38), 5-4 | Sportsman's Park III (26-21) | 44-47 | |
| » Starters: Stan Williams vs Larry Jackson | Sixth | 11 out |
| Sunday, July 23 |
| » Lost to Dodgers (56-38), 2-1 | Sportsman's Park III (26-22) | 44-48 | Lost 2 |
| » Starters: Johnny Podres vs Bob Gibson | Sixth | 12½ out |
| » Major-league debuts: Tom Satriano (Dodgers) |
| Tuesday, July 25 |
| » Defeated Cubs (39-54), 6-5 | Wrigley Field (4-4) | 45-48 | |
| » Starters: Ray Sadecki vs Jack Curtis | Sixth | 12 out |
| Wednesday, July 26 |
| » Lost to Cubs (40-54), 7-6 | Wrigley Field (4-5) | 45-49 | |
| » Starters: Curt Simmons vs Don Cardwell | Sixth | 13 out |
| Thursday, July 27 |
| » Lost to Cubs (41-54), 3-2 | Wrigley Field (4-6) | 45-50 | Lost 2 |
| » Starters: Al Cicotte vs Glen Hobbie | Sixth | 14 out |
| Friday, July 28 |
| » Defeated Braves (48-47), 6-2 | County Stadium (3-3) | 46-50 | |
| » Starters: Larry Jackson vs Bob Hendley | Sixth | 14 out |
| Saturday, July 29 |
| » Lost to Braves (49-47), 2-1 | County Stadium (3-4) | 46-51 | |
| » Starters: Ernie Broglio vs Bob Buhl | Sixth | 14 out |
| Sunday, July 30 |
| » Defeated Braves (49-48), 5-3 | County Stadium (4-4) | 47-51 | |
| » Starters: Ray Sadecki vs Lew Burdette | Sixth | 14½ out |
| » Lost to Braves (50-48), 3-2 | County Stadium (4-5) | 47-52 | |
| » Starters: Bob Gibson vs Warren Spahn | Sixth | 14½ out |
| Wednesday, August 2 |
| » Defeated Pirates (45-49), 4-2 | Sportsman's Park III (27-22) | 48-52 | |
| » Starters: Bob Friend vs Larry Jackson | Fifth | 14½ out |
| Future Cardinal Danny Sheaffer is born in Jacksonville, FL. |
| Thursday, August 3 |
| » Lost to Pirates (46-49), 19-0 | Sportsman's Park III (27-23) | 48-53 | |
| » Starters: Harvey Haddix vs Al Cicotte | Sixth | 15½ out |
| Friday, August 4 |
| » Defeated Phillies (30-70), 9-8 | Sportsman's Park III (28-23) | 49-53 | |
| » Starters: Don Ferrarese vs Ernie Broglio | Fifth | 15½ out |
| Saturday, August 5 |
| » Defeated Phillies (30-71), 7-0 | Sportsman's Park III (29-23) | 50-53 | Won 2 |
| » Starters: Paul Brown vs Curt Simmons | Sixth | 14½ out |
| Sunday, August 6 |
| » Defeated Phillies (30-72), 3-1 | Sportsman's Park III (30-23) | 51-53 | Won 3 |
| » Starters: Frank Sullivan vs Ray Sadecki | Fifth | 13 out |
| » Defeated Phillies (30-73), 3-2 | Sportsman's Park III (31-23) | 52-53 | Won 4 |
| » Starters: Jim Owens vs Bob Gibson | Fifth | 13 out |
| Monday, August 7 |
| » Defeated Reds (68-43), 5-1 | Sportsman's Park III (32-23) | 53-53 | Won 5 |
| » Starters: Ken Johnson vs Larry Jackson | Fifth | 12½ out |
| Tuesday, August 8 |
| » Defeated Reds (68-44), 6-5 | Sportsman's Park III (33-23) | 54-53 | Won 6 |
| » Starters: Bob Purkey vs Ernie Broglio | Fifth | 12½ out |
| Wednesday, August 9 |
| » Defeated Pirates (51-52), 4-0 | Forbes Field (3-4) | 55-53 | Won 7 |
| » Starters: Curt Simmons vs Joe Gibbon | Fifth | 12½ out |
| Thursday, August 10 |
| » Defeated Pirates (51-53), 3-2 | Forbes Field (4-4) | 56-53 | Won 8 |
| » Starters: Ray Sadecki vs Earl Francis | Fourth | 12 out |
| Saturday, August 12 |
| » Lost to Dodgers (68-40), 5-1 | Los Angeles Memorial Coliseum (3-6) | 56-54 | |
| » Starters: Larry Jackson vs Johnny Podres | Fifth | 13 out |
| Sunday, August 13 |
| » Lost to Dodgers (69-40), 8-0 | Los Angeles Memorial Coliseum (3-7) | 56-55 | Lost 2 |
| » Starters: Bob Gibson vs Stan Williams | Fifth | 14 out |
| Monday, August 14 |
| » Defeated Dodgers (69-41), 5-0 | Los Angeles Memorial Coliseum (4-7) | 57-55 | |
| » Starters: Ernie Broglio vs Don Drysdale | Fifth | 13 out |
| Tuesday, August 15 |
| » Lost to Giants (61-50), 3-2 | Candlestick Park (5-4) | 57-56 | |
| » Starters: Curt Simmons vs Juan Marichal | Fifth | 13 out |
| Wednesday, August 16 |
| » Lost to Giants (62-50), 4-3 | Candlestick Park (5-5) | 57-57 | Lost 2 |
| » Starters: Ray Sadecki vs Jack Sanford | Fifth | 13½ out |
| Thursday, August 17 |
| » Defeated Giants (62-51), 2-0 | Candlestick Park (6-5) | 58-57 | |
| » Starters: Larry Jackson vs Mike McCormick | Fifth | 13 out |
| Friday, August 18 |
| » Lost to Reds (74-46), 6-3 | Crosley Field (1-5) | 58-58 | |
| » Starters: Bob Gibson vs Ken Johnson | Fifth | 14 out |
| Saturday, August 19 |
| » Lost to Reds (75-46), 3-1 | Crosley Field (1-6) | 58-59 | Lost 2 |
| » Starters: Curt Simmons vs Joey Jay | Fifth | 15 out |
| Sunday, August 20 |
| » Defeated Reds (75-47), 7-4 | Crosley Field (2-6) | 59-59 | |
| » Starters: Ray Sadecki vs Jim O'Toole | Fifth | 14 out |
| Tuesday, August 22 |
| » Defeated Dodgers (69-48), 5-4 | Sportsman's Park III (34-23) | 60-59 | Won 2 |
| » Starters: Johnny Podres vs Larry Jackson | Fifth | 12½ out |
| Wednesday, August 23 |
| » Defeated Dodgers (69-49), 8-7 | Sportsman's Park III (35-23) | 61-59 | Won 3 |
| » Starters: Don Drysdale vs Curt Simmons | Fifth | 11½ out |
| Thursday, August 24 |
| » Defeated Dodgers (69-50), 10-1 | Sportsman's Park III (36-23) | 62-59 | Won 4 |
| » Starters: Stan Williams vs Ernie Broglio | Fifth | 11½ out |
| Friday, August 25 |
| » Defeated Giants (68-53), 7-3 | Sportsman's Park III (37-23) | 63-59 | Won 5 |
| » Starters: Billy O'Dell vs Ray Sadecki | Fifth | 10½ out |
| Saturday, August 26 |
| » Defeated Giants (68-54), 8-5 | Sportsman's Park III (38-23) | 64-59 | Won 6 |
| » Starters: Mike McCormick vs Bob Gibson | Fifth | 9½ out |
| Future Cardinal Jeff Parrett is born in Indianapolis, IN. |
| Sunday, August 27 |
| » Defeated Giants (68-55), 6-0 | Sportsman's Park III (39-23) | 65-59 | Won 7 |
| » Starters: Juan Marichal vs Larry Jackson | Fifth | 10 out |
| Tuesday, August 29 |
| » Defeated Phillies (35-91), 5-4 | Shibe Park (3-3) | 66-59 | Won 8 |
| » Starters: Curt Simmons vs John Buzhardt | Fifth | 10½ out |
| » Lost to Phillies (36-91), 4-3 | Shibe Park (3-4) | 66-60 | |
| » Starters: Bob Miller vs Jim Owens | Fifth | 10½ out |
| Wednesday, August 30 |
| » Lost to Phillies (37-91), 4-3 | Shibe Park (3-5) | 66-61 | Lost 2 |
| » Starters: Ray Sadecki vs Frank Sullivan | Fifth | 10½ out |
| Thursday, August 31 |
| » Defeated Phillies (37-92), 2-1 | Shibe Park (4-5) | 67-61 | |
| » Starters: Bob Gibson vs Art Mahaffey | Fifth | 10 out |
| Friday, September 1 |
| » Defeated Pirates (61-65), 8-4 | Sportsman's Park III (40-23) | 68-61 | Won 2 |
| » Starters: Joe Gibbon vs Larry Jackson | Fifth | 9½ out |
| Saturday, September 2 |
| » Lost to Pirates (62-65), 5-4 | Sportsman's Park III (40-24) | 68-62 | |
| » Starters: Harvey Haddix vs Ernie Broglio | Fifth | 10½ out |
| Sunday, September 3 |
| » Lost to Pirates (63-65), 8-1 | Sportsman's Park III (40-25) | 68-63 | Lost 2 |
| » Starters: Bob Friend vs Curt Simmons | Fifth | 10½ out |
| Monday, September 4 |
| » Defeated Pirates (63-66), 9-4 | Sportsman's Park III (41-25) | 69-63 | |
| » Starters: Earl Francis vs Ray Sadecki | Fifth | 10 out |
| Tuesday, September 5 |
| » Lost to Reds (82-55), 5-2 | Sportsman's Park III (41-26) | 69-64 | |
| » Starters: Bob Purkey vs Bob Gibson | Fifth | 11 out |
| Wednesday, September 6 |
| » Defeated Reds (82-56), 11-5 | Sportsman's Park III (42-26) | 70-64 | |
| » Starters: Joey Jay vs Larry Jackson | Fifth | 10 out |
| Friday, September 8 |
| » Lost to Reds (83-56), 3-2 | Crosley Field (2-7) | 70-65 | |
| » Starters: Ernie Broglio vs Jim O'Toole | Fifth | 11 out |
| Saturday, September 9 |
| » Lost to Reds (84-56), 4-3 | Crosley Field (2-8) | 70-66 | Lost 2 |
| » Starters: Curt Simmons vs Ken Johnson | Fifth | 12 out |
| Sunday, September 10 |
| » Lost to Reds (85-56), 5-2 | Crosley Field (2-9) | 70-67 | Lost 3 |
| » Starters: Ray Sadecki vs Bob Purkey | Fifth | 13 out |
| Monday, September 11 |
| » Defeated Braves (76-62), 4-1 | Sportsman's Park III (43-26) | 71-67 | |
| » Starters: Lew Burdette vs Larry Jackson | Fifth | 12½ out |
| Tuesday, September 12 |
| » Defeated Braves (76-63), 4-1 | Sportsman's Park III (44-26) | 72-67 | Won 2 |
| » Starters: Bob Hendley vs Bob Gibson | Fifth | 12½ out |
| Thursday, September 14 |
| » Defeated Cubs (59-81), 8-7 | Sportsman's Park III (45-26) | 73-67 | Won 3 |
| » Starters: Don Cardwell vs Ernie Broglio | Fifth | 12 out |
| » Defeated Cubs (59-82), 6-5 | Sportsman's Park III (46-26) | 74-67 | Won 4 |
| » Starters: Jack Curtis vs Curt Simmons | Fifth | 12 out |
| Saturday, September 16 |
| » Defeated Pirates (68-72), 6-3 | Forbes Field (5-4) | 75-67 | Won 5 |
| » Starters: Ray Sadecki vs Earl Francis | Fifth | 12 out |
| Sunday, September 17 |
| » Defeated Pirates (68-73), 3-0 | Forbes Field (6-4) | 76-67 | Won 6 |
| » Starters: Larry Jackson vs Al McBean | Fourth | 11 out |
| Monday, September 18 |
| » Lost to Pirates (69-73), 8-6 | Forbes Field (6-5) | 76-68 | |
| » Starters: Bob Gibson vs Larry Foss | Fourth | 11½ out |
| » Major-league debuts: Larry Foss (Pirates) |
| Tuesday, September 19 |
| » Defeated Phillies (44-101), 3-0 | Sportsman's Park III (47-26) | 77-68 | |
| » Starters: John Buzhardt vs Curt Simmons | Fourth | 11½ out |
| Wednesday, September 20 |
| » Lost to Phillies (45-101), 6-1 | Sportsman's Park III (47-27) | 77-69 | |
| » Starters: Don Ferrarese vs Ernie Broglio | Fourth | 12½ out |
| » Major-league debuts: Ray Washburn (Cardinals) |
| Friday, September 22 |
| » Lost to Dodgers (85-61), 6-3 | Sportsman's Park III (47-28) | 77-70 | Lost 2 |
| » Starters: Don Drysdale vs Ray Sadecki | Fifth | 12½ out |
| Future Cardinal Vince Coleman is born in Jacksonville, FL. |
| Saturday, September 23 |
| » Lost to Dodgers (86-61), 8-5 | Sportsman's Park III (47-29) | 77-71 | Lost 3 |
| » Starters: Johnny Podres vs Larry Jackson | Fifth | 13½ out |
| Sunday, September 24 |
| » Defeated Dodgers (86-62), 8-7 | Sportsman's Park III (48-29) | 78-71 | |
| » Starters: Sandy Koufax vs Bob Gibson | Fifth | 12½ out |
| Monday, September 25 |
| » Lost to Braves (80-70), 2-1 | County Stadium (4-6) | 78-72 | |
| » Starters: Ray Washburn vs Carl Willey | Fifth | 13 out |
| Tuesday, September 26 |
| » Lost to Braves (81-70), 9-2 | County Stadium (4-7) | 78-73 | Lost 2 |
| » Starters: Ray Sadecki vs Lew Burdette | Fifth | 14 out |
| Wednesday, September 27 |
| » Lost to Cubs (63-89), 5-2 | Wrigley Field (4-7) | 78-74 | Lost 3 |
| » Starters: Larry Jackson vs Don Cardwell | |