| Sunday, January 29 |
| Future Athletic Mike Aldrete is born in Carmel, CA. |
| Wednesday, March 29 |
| Future Athletic Mike Kingery is born in St. James, MN. |
| Tuesday, April 4 |
| Future Athletic Brad Komminsk is born in Lima, OH. |
| Tuesday, April 11 |
| » Defeated Red Sox (0-1), 5-2 | Fenway Park (1-0) | 1-0 | |
| » Starters: Ray Herbert vs Bill Monbouquette | First | -- |
| » Major-league debuts: Chuck Schilling and Carl Yastrzemski (Red Sox) |
| Friday, April 14 |
| Former Athletic Cy Falkenberg dies in San Francisco, CA at the age of 81. |
| Saturday, April 15 |
| » Lost to Yankees (1-1), 5-3 | Yankee Stadium (0-1) | 1-1 | |
| » Starters: Bud Daley vs Bob Turley | Second | ½ out |
| » Major-league debuts: Jay Hankins (Athletics) |
| Sunday, April 16 |
| » Major-league debuts: Bill Pleis (Twins) |
| Monday, April 17 |
| » Lost to Yankees (2-1), 3-0 | Yankee Stadium (0-2) | 1-2 | Lost 2 |
| » Starters: Jerry Walker vs Whitey Ford | Fourth | 2 out |
| Wednesday, April 19 |
| » Major-league debuts: Ed Hobaugh (Senators) |
| Friday, April 21 |
| » Lost to Indians (4-3), 5-3 | Municipal Stadium (0-1) | 1-3 | Lost 3 |
| » Starters: Mudcat Grant vs Ray Herbert | Seventh | 3 out |
| Saturday, April 22 |
| » Defeated Indians (4-4), 5-2 | Municipal Stadium (1-1) | 2-3 | |
| » Starters: Johnny Antonelli vs Bud Daley | Seventh | 2½ out |
| Sunday, April 23 |
| » Lost to Indians (5-4), 10-8 | Municipal Stadium (1-2) | 2-4 | |
| » Starters: Bobby Locke vs Jerry Walker | Eighth | 4 out |
| » Major-league debuts: Steve Hamilton (Indians) |
| Monday, April 24 |
| » Lost to Twins (8-2), 10-6 | Municipal Stadium (1-3) | 2-5 | Lost 2 |
| » Starters: Jim Kaat vs Don Larsen | Eighth | 5 out |
| Tuesday, April 25 |
| » Defeated Twins (8-3), 20-2 | Municipal Stadium (2-3) | 3-5 | |
| » Starters: Ted Sadowski vs Norm Bass | Seventh | 4½ out |
| » Major-league debuts: Fred Bruckbauer (Twins) |
| Thursday, April 27 |
| » Lost to White Sox (5-5), 9-1 | Municipal Stadium (2-4) | 3-6 | |
| » Starters: Early Wynn vs Bud Daley | Eighth | 4½ out |
| Friday, April 28 |
| » Lost to White Sox (6-5), 4-2 | Municipal Stadium (2-5) | 3-7 | Lost 2 |
| » Starters: Cal McLish vs Ray Herbert | Eighth | 4½ out |
| Saturday, April 29 |
| » Defeated White Sox (6-6), 13-9 | Municipal Stadium (3-5) | 4-7 | |
| » Starters: Billy Pierce vs Jerry Walker | Sixth | 4½ out |
| Sunday, April 30 |
| » Lost to Angels (4-8), 6-4 | Wrigley Field (0-1) | 4-8 | |
| » Starters: Joe Nuxhall vs Ron Moeller | Seventh | 4½ out |
| » Defeated Angels (4-9), 3-2 | Wrigley Field (1-1) | 5-8 | |
| » Starters: Jim Archer vs Jerry Casale | Seventh | 4½ out |
| » Major-league debuts: Jim Archer (Athletics) |
| Tuesday, May 2 |
| » Defeated Red Sox (7-8), 7-4 | Municipal Stadium (4-5) | 6-8 | Won 2 |
| » Starters: Ike Delock vs Bud Daley | Sixth | 4½ out |
| Wednesday, May 3 |
| » Defeated Red Sox (7-9), 9-8 | Municipal Stadium (5-5) | 7-8 | Won 3 |
| » Starters: Billy Muffett vs Ray Herbert | Fourth | 3½ out |
| Saturday, May 6 |
| » Lost to Orioles (11-9), 6-0 | Municipal Stadium (5-6) | 7-9 | |
| » Starters: Steve Barber vs Ken Johnson | Fifth | 5½ out |
| Sunday, May 7 |
| » Defeated Orioles (11-10), 5-4 | Municipal Stadium (6-6) | 8-9 | |
| » Starters: Jack Fisher vs Jerry Walker | Fourth | 6 out |
| Tuesday, May 9 |
| » Defeated Yankees (13-8), 5-4 | Municipal Stadium (7-6) | 9-9 | Won 2 |
| » Starters: Whitey Ford vs Ray Herbert | Fourth | 5½ out |
| Wednesday, May 10 |
| » Lost to Yankees (14-8), 9-4 | Municipal Stadium (7-7) | 9-10 | |
| » Starters: Ralph Terry vs Bud Daley | Fourth | 6½ out |
| Friday, May 12 |
| » Lost to White Sox (9-14), 2-1 | Comiskey Park I (0-1) | 9-11 | Lost 2 |
| » Starters: Norm Bass vs Early Wynn | Seventh | 7 out |
| Saturday, May 13 |
| » Lost to White Sox (10-14), 10-1 | Comiskey Park I (0-2) | 9-12 | Lost 3 |
| » Starters: Jerry Walker vs Billy Pierce | Seventh | 8 out |
| Sunday, May 14 |
| » Lost to White Sox (11-14), 6-1 | Comiskey Park I (0-3) | 9-13 | Lost 4 |
| » Starters: Ray Herbert vs Bob Shaw | Sixth | 7 out |
| » Defeated White Sox (11-15), 5-3 | Comiskey Park I (1-3) | 10-13 | |
| » Starters: Joe Nuxhall vs Herb Score | Sixth | 7 out |
| Monday, May 15 |
| » Defeated Angels (9-17), 5-3 | Municipal Stadium (8-7) | 11-13 | Won 2 |
| » Starters: Ron Moeller vs Bud Daley | Sixth | 7 out |
| Tuesday, May 16 |
| » Defeated Angels (9-18), 6-4 | Municipal Stadium (9-7) | 12-13 | Won 3 |
| » Starters: Eli Grba vs Norm Bass | Sixth | 7 out |
| Thursday, May 18 |
| » Defeated Twins (16-14), 4-3 | Metropolitan Stadium (1-0) | 13-13 | Won 4 |
| » Starters: Ray Herbert vs Jim Kaat | Fourth | 6½ out |
| Friday, May 19 |
| » Lost to Twins (17-14), 11-1 | Metropolitan Stadium (1-1) | 13-14 | |
| » Starters: Ed Rakow vs Jack Kralick | Fifth | 7 out |
| Saturday, May 20 |
| » Lost to Twins (18-14), 2-0 | Metropolitan Stadium (1-2) | 13-15 | Lost 2 |
| » Starters: Joe Nuxhall vs Camilo Pascual | Fifth | 7 out |
| Sunday, May 21 |
| » Lost to Tigers (24-11), 5-3 | Municipal Stadium (9-8) | 13-16 | Lost 3 |
| » Starters: Frank Lary vs Bud Daley | Seventh | 8 out |
| Monday, May 22 |
| » Lost to Tigers (25-11), 10-2 | Municipal Stadium (9-9) | 13-17 | Lost 4 |
| » Starters: Phil Regan vs Norm Bass | Eighth | 9 out |
| Tuesday, May 23 |
| » Lost to Senators (18-20), 7-3 | Municipal Stadium (9-10) | 13-18 | Lost 5 |
| » Starters: Ed Hobaugh vs Ray Herbert | Eighth | 10 out |
| Wednesday, May 24 |
| » Defeated Senators (18-21), 6-5 | Municipal Stadium (10-10) | 14-18 | |
| » Starters: Tom Sturdivant vs Jim Archer | Eighth | 10 out |
| Thursday, May 25 |
| » Defeated Senators (18-22), 4-3 | Municipal Stadium (11-10) | 15-18 | Won 2 |
| » Starters: Dick Donovan vs Joe Nuxhall | Sixth | 9 out |
| Saturday, May 27 |
| » Defeated Indians (23-16), 7-5 | Cleveland Stadium (1-0) | 16-18 | Won 3 |
| » Starters: Bud Daley vs Wynn Hawkins | Seventh | 7½ out |
| Sunday, May 28 |
| » Lost to Indians (24-16), 9-1 | Cleveland Stadium (1-1) | 16-19 | |
| » Starters: Ray Herbert vs Gary Bell | Sixth | 8 out |
| » Defeated Indians (24-17), 8-4 | Cleveland Stadium (2-1) | 17-19 | |
| » Starters: Norm Bass vs Jim Perry | Sixth | 8 out |
| Tuesday, May 30 |
| » Lost to Tigers (29-14), 5-3 | Tiger Stadium (0-1) | 17-20 | |
| » Starters: Jim Archer vs Don Mossi | Sixth | 8 out |
| » Defeated Tigers (29-15), 9-3 | Tiger Stadium (1-1) | 18-20 | |
| » Starters: Jerry Walker vs Paul Foytack | Sixth | 8 out |
| Wednesday, May 31 |
| » Defeated Tigers (29-16), 6-4 | Tiger Stadium (2-1) | 19-20 | Won 2 |
| » Starters: Joe Nuxhall vs Frank Lary | Sixth | 7 out |
| Thursday, June 1 |
| » Tied Tigers, 4-4 | Tiger Stadium (2-1) | 19-20 | |
| » Starters: Ray Herbert vs Phil Regan | Sixth | 7 out |
| Friday, June 2 |
| » Lost to Senators (24-23), 12-4 | Griffith Stadium (0-1) | 19-21 | |
| » Starters: Bud Daley vs Dick Donovan | Sixth | 8 out |
| Saturday, June 3 |
| » Defeated Senators (24-24), 8-0 | Griffith Stadium (1-1) | 20-21 | |
| » Starters: Norm Bass vs Hal Woodeshick | Sixth | 8 out |
| Sunday, June 4 |
| » Defeated Senators (24-25), 8-5 | Griffith Stadium (2-1) | 21-21 | Won 2 |
| » Starters: Jim Archer vs Ed Hobaugh | Fifth | 8½ out |
| Monday, June 5 |
| » Lost to Red Sox (21-24), 6-2 | Fenway Park (1-1) | 21-22 | |
| » Starters: Ray Herbert vs Mike Fornieles | Fifth | 8 out |
| » Defeated Red Sox (21-25), 10-6 | Fenway Park (2-1) | 22-22 | |
| » Starters: Joe Nuxhall vs Tom Brewer | Fifth | 8 out |
| Former Athletic Syd Smith dies in Orangeburg, SC at the age of 78. |
| Tuesday, June 6 |
| » Lost to Red Sox (22-25), 5-3 | Fenway Park (2-2) | 22-23 | |
| » Starters: Jerry Walker vs Bill Monbouquette | Fifth | 8 out |
| Wednesday, June 7 |
| » Lost to Red Sox (23-25), 6-2 | Fenway Park (2-3) | 22-24 | Lost 2 |
| » Starters: Bud Daley vs Don Schwall | Sixth | 9 out |
| Thursday, June 8 |
| » Lost to Yankees (30-19), 6-1 | Yankee Stadium (0-3) | 22-25 | Lost 3 |
| » Starters: Norm Bass vs Bill Stafford | Sixth | 9 out |
| » Defeated Yankees (30-20), 9-6 | Yankee Stadium (1-3) | 23-25 | |
| » Starters: Jim Archer vs Danny McDevitt | Sixth | 9 out |
| » Major-league debuts: Hal Reniff (Yankees) |
| Friday, June 9 |
| » Lost to Yankees (31-20), 8-6 | Yankee Stadium (1-4) | 23-26 | |
| » Starters: Ray Herbert vs Jim Coates | Seventh | 10 out |
| Saturday, June 10 |
| » Lost to Yankees (32-20), 5-3 | Yankee Stadium (1-5) | 23-27 | Lost 2 |
| » Starters: Joe Nuxhall vs Whitey Ford | Seventh | 10 out |
| Sunday, June 11 |
| » Lost to Indians (36-19), 7-3 | Cleveland Stadium (2-2) | 23-28 | Lost 3 |
| » Starters: Jerry Walker vs Johnny Antonelli | Seventh | 12 out |
| » Lost to Indians (37-19), 4-3 | Cleveland Stadium (2-3) | 23-29 | Lost 4 |
| » Starters: Ed Rakow vs Mudcat Grant | Seventh | 12 out |
| Monday, June 12 |
| » Defeated Indians (37-20), 7-5 | Cleveland Stadium (3-3) | 24-29 | |
| » Starters: Bob Shaw vs Wynn Hawkins | Seventh | 11 out |
| Tuesday, June 13 |
| » Lost to Twins (22-35), 8-6 | Metropolitan Stadium (1-3) | 24-30 | |
| » Starters: Norm Bass vs Jim Kaat | Seventh | 12 out |
| Wednesday, June 14 |
| » Defeated Twins (22-36), 9-2 | Metropolitan Stadium (2-3) | 25-30 | |
| » Starters: Jim Archer vs Camilo Pascual | Sixth | 11 out |
| Thursday, June 15 |
| » Lost to Twins (23-36), 4-3 | Metropolitan Stadium (2-4) | 25-31 | |
| » Starters: Joe Nuxhall vs Jack Kralick | Fifth | 11 out |
| Friday, June 16 |
| » Defeated Angels (21-42), 4-0 | Municipal Stadium (12-10) | 26-31 | |
| » Starters: Ken McBride vs Lew Krausse | Fifth | 11 out |
| Saturday, June 17 |
| » Lost to Angels (22-42), 3-0 | Municipal Stadium (12-11) | 26-32 | |
| » Starters: Ted Bowsfield vs Bob Shaw | Seventh | 12 out |
| Sunday, June 18 |
| » Lost to Angels (23-42), 5-3 | Municipal Stadium (12-12) | 26-33 | Lost 2 |
| » Starters: Ryne Duren vs Norm Bass | Eighth | 12 out |
| Monday, June 19 |
| » Defeated Yankees (38-24), 4-3 | Municipal Stadium (13-12) | 27-33 | |
| » Manager: Hank Bauer |
| » Starters: Rollie Sheldon vs Jim Archer | Eighth | 11½ out |
| Tuesday, June 20 |
| » Lost to Yankees (39-24), 6-2 | Municipal Stadium (13-13) | 27-34 | |
| » Starters: Bill Stafford vs Joe Nuxhall | Eighth | 12½ out |
| Wednesday, June 21 |
| » Lost to Yankees (40-24), 5-3 | Municipal Stadium (13-14) | 27-35 | Lost 2 |
| » Starters: Bud Daley vs Bob Shaw | Eighth | 13 out |
| Thursday, June 22 |
| » Lost to Yankees (41-24), 8-3 | Municipal Stadium (13-15) | 27-36 | Lost 3 |
| » Starters: Whitey Ford vs Norm Bass | Eighth | 14 out |
| Friday, June 23 |
| » Lost to Red Sox (35-31), 5-4 | Municipal Stadium (13-16) | 27-37 | Lost 4 |
| » Starters: Gene Conley vs Lew Krausse | Eighth | 15 out |
| Saturday, June 24 |
| » Defeated Red Sox (35-32), 9-3 | Municipal Stadium (14-16) | 28-37 | |
| » Starters: Ike Delock vs Jim Archer | Eighth | 15 out |
| Sunday, June 25 |
| » Lost to Red Sox (36-32), 7-4 | Municipal Stadium (14-17) | 28-38 | |
| » Starters: Don Schwall vs Joe Nuxhall | Sixth | 15 out |
| » Defeated Red Sox (36-33), 3-2 | Municipal Stadium (15-17) | 29-38 | |
| » Starters: Billy Muffett vs Bob Shaw | Sixth | 15 out |
| Tuesday, June 27 |
| » Lost to Orioles (37-34), 5-3 | Municipal Stadium (15-18) | 29-39 | |
| » Starters: Milt Pappas vs Norm Bass | Seventh | 15 out |
| » Lost to Orioles (38-34), 7-2 | Municipal Stadium (15-19) | 29-40 | Lost 2 |
| » Starters: Chuck Estrada vs Art Ditmar | Seventh | 15 out |
| Wednesday, June 28 |
| » Lost to Orioles (39-34), 5-4 | Municipal Stadium (15-20) | 29-41 | Lost 3 |
| » Starters: Steve Barber vs Jim Archer | Eighth | 16 out |
| Thursday, June 29 |
| » Lost to Orioles (40-34), 6-2 | Municipal Stadium (15-21) | 29-42 | Lost 4 |
| » Starters: Dick Hall vs Lew Krausse | Eighth | 17 out |
| Friday, June 30 |
| » Lost to Twins (29-45), 8-2 | Municipal Stadium (15-22) | 29-43 | Lost 5 |
| » Starters: Jack Kralick vs Joe Nuxhall | Eighth | 18 out |
| Saturday, July 1 |
| » Lost to Twins (30-45), 9-3 | Municipal Stadium (15-23) | 29-44 | Lost 6 |
| » Starters: Jim Kaat vs Bob Shaw | Ninth | 19 out |
| Sunday, July 2 |
| » Defeated Twins (30-46), 8-7 | Municipal Stadium (16-23) | 30-44 | |
| » Starters: Pedro Ramos vs Jerry Walker | Eighth | 18 out |
| Monday, July 3 |
| » Lost to Angels (30-48), 5-3 | Wrigley Field (1-2) | 30-45 | |
| » Starters: Jim Archer vs Ryne Duren | Ninth | 18½ out |
| Tuesday, July 4 |
| » Lost to Angels (31-48), 12-5 | Wrigley Field (1-3) | 30-46 | Lost 2 |
| » Starters: Lew Krausse vs Ted Bowsfield | Tenth | 19½ out |
| » Lost to Angels (32-48), 7-5 | Wrigley Field (1-4) | 30-47 | Lost 3 |
| » Starters: Joe Nuxhall vs Ken McBride | Tenth | 19½ out |
| Wednesday, July 5 |
| » Defeated White Sox (39-42), 8-3 | Municipal Stadium (17-23) | 31-47 | |
| » Starters: Juan Pizarro vs Bob Shaw | Tenth | 19 out |
| Thursday, July 6 |
| » Lost to White Sox (40-42), 4-3 | Municipal Stadium (17-24) | 31-48 | |
| » Starters: Early Wynn vs Jerry Walker | Tenth | 20 out |
| Friday, July 7 |
| » Lost to Orioles (45-37), 6-2 | Memorial Stadium (0-1) | 31-49 | Lost 2 |
| » Starters: Ed Rakow vs Chuck Estrada | Ninth | 21 out |
| » Lost to Orioles (46-37), 5-0 | Memorial Stadium (0-2) | 31-50 | Lost 3 |
| » Starters: Jim Archer vs Hal Brown | Ninth | 21 out |
| Saturday, July 8 |
| » Lost to Orioles (47-37), 7-2 | Memorial Stadium (0-3) | 31-51 | Lost 4 |
| » Starters: Lew Krausse vs Milt Pappas | Ninth | 22 out |
| Sunday, July 9 |
| » Lost to Orioles (48-37), 8-0 | Memorial Stadium (0-4) | 31-52 | Lost 5 |
| » Starters: Bob Shaw vs Steve Barber | Tenth | 23 out |
| Friday, July 14 |
| » Defeated Senators (38-47), 8-3 | Griffith Stadium (3-1) | 32-52 | |
| » Starters: Ed Rakow vs Joe McClain | Tenth | 21½ out |
| » Defeated Senators (38-48), 9-7 | Griffith Stadium (4-1) | 33-52 | Won 2 |
| » Starters: Bob Shaw vs Bennie Daniels | Tenth | 21½ out |
| Saturday, July 15 |
| » Lost to Senators (39-48), 7-1 | Griffith Stadium (4-2) | 33-53 | |
| » Starters: Lew Krausse vs Dick Donovan | Tenth | 22½ out |
| Sunday, July 16 |
| » Lost to Tigers (57-31), 11-1 | Tiger Stadium (2-2) | 33-54 | Lost 2 |
| » Starters: Jim Archer vs Don Mossi | Tenth | 24½ out |
| » Lost to Tigers (58-31), 8-3 | Tiger Stadium (2-3) | 33-55 | Lost 3 |
| » Starters: Jerry Walker vs Phil Regan | Tenth | 24½ out |
| Monday, July 17 |
| » Lost to Tigers (59-31), 7-4 | Tiger Stadium (2-4) | 33-56 | Lost 4 |
| » Starters: Joe Nuxhall vs Paul Foytack | Tenth | 25½ out |
| Tuesday, July 18 |
| » Lost to White Sox (46-47), 4-3 | Comiskey Park I (1-4) | 33-57 | Lost 5 |
| » Starters: Ed Rakow vs Juan Pizarro | Tenth | 26 out |
| Wednesday, July 19 |
| » Lost to White Sox (47-47), 6-5 | Comiskey Park I (1-5) | 33-58 | Lost 6 |
| » Starters: Bob Shaw vs Ray Herbert | Tenth | 25½ out |
| Friday, July 21 |
| » Defeated Tigers (60-34), 3-2 | Municipal Stadium (18-24) | 34-58 | |
| » Starters: Phil Regan vs Jim Archer | Tenth | 25½ out |
| Sunday, July 23 |
| » Lost to Tigers (61-34), 6-4 | Municipal Stadium (18-25) | 34-59 | |
| » Starters: Paul Foytack vs Bob Shaw | Tenth | 27 out |
| » Lost to Tigers (62-34), 17-14 | Municipal Stadium (18-26) | 34-60 | Lost 2 |
| » Starters: Frank Lary vs Ed Rakow | Tenth | 27 out |
| Tuesday, July 25 |
| » Defeated Indians (53-46), 3-2 | Municipal Stadium (19-26) | 35-60 | |
| » Starters: Jim Perry vs Jerry Walker | Tenth | 27 out |
| Wednesday, July 26 |
| » Lost to Indians (54-46), 12-5 | Municipal Stadium (19-27) | 35-61 | |
| » Starters: Gary Bell vs Jim Archer | Tenth | 28 out |
| Thursday, July 27 |
| » Defeated Indians (54-47), 2-1 | Municipal Stadium (20-27) | 36-61 | |
| » Starters: Mudcat Grant vs Art Ditmar | Tenth | 28 out |
| Friday, July 28 |
| » Lost to Senators (44-55), 10-6 | Municipal Stadium (20-28) | 36-62 | |
| » Starters: Marty Kutyna vs Ed Rakow | Tenth | 28 out |
| Saturday, July 29 |
| » Defeated Senators (44-56), 2-1 | Municipal Stadium (21-28) | 37-62 | |
| » Starters: Gabe Gabler vs Bob Shaw | Ninth | 28 out |
| Sunday, July 30 |
| » Lost to Senators (45-56), 4-0 | Municipal Stadium (21-29) | 37-63 | |
| » Starters: Bennie Daniels vs Jerry Walker | Ninth | 27½ out |
| Wednesday, August 2 |
| » Lost to Yankees (66-36), 6-5 | Yankee Stadium (1-6) | 37-64 | Lost 2 |
| » Starters: Jim Archer vs Whitey Ford | Ninth | 29½ out |
| » Lost to Yankees (67-36), 12-5 | Yankee Stadium (1-7) | 37-65 | Lost 3 |
| » Starters: Art Ditmar vs Ralph Terry | Ninth | 29½ out |
| Thursday, August 3 |
| » Defeated Yankees (67-37), 6-1 | Yankee Stadium (2-7) | 38-65 | |
| » Starters: Bob Shaw vs Bud Daley | Ninth | 28½ out |
| Friday, August 4 |
| » Defeated Red Sox (50-59), 5-0 | Fenway Park (3-3) | 39-65 | Won 2 |
| » Starters: Norm Bass vs Bill Monbouquette | Tenth | 28½ out |
| Saturday, August 5 |
| » Lost to Red Sox (51-59), 10-4 | Fenway Park (3-4) | 39-66 | |
| » Starters: Jerry Walker vs Gene Conley | Tenth | 29½ out |
| Sunday, August 6 |
| » Lost to Red Sox (52-59), 4-2 | Fenway Park (3-5) | 39-67 | Lost 2 |
| » Starters: Ed Rakow vs Galen Cisco | Tenth | 30½ out |
| » Defeated Red Sox (52-60), 1-0 | Fenway Park (4-5) | 40-67 | |
| » Starters: Jim Archer vs Tracy Stallard | Tenth | 30½ out |
| Monday, August 7 |
| » Lost to Orioles (62-49), 5-4 | Memorial Stadium (0-5) | 40-68 | |
| » Starters: Art Ditmar vs Chuck Estrada | Tenth | 31½ out |
| Tuesday, August 8 |
| » Lost to Orioles (63-49), 7-0 | Memorial Stadium (0-6) | 40-69 | Lost 2 |
| » Starters: Bob Shaw vs Steve Barber | Tenth | 32 out |
| » Defeated Orioles (63-50), 6-5 | Memorial Stadium (1-6) | 41-69 | |
| » Starters: Norm Bass vs Hal Brown | Tenth | 32 out |
| Wednesday, August 9 |
| » Defeated Orioles (63-51), 2-1 | Memorial Stadium (2-6) | 42-69 | Won 2 |
| » Starters: Jerry Walker vs Jack Fisher | Tenth | 32 out |
| Thursday, August 10 |
| » Lost to Orioles (64-51), 8-0 | Memorial Stadium (2-7) | 42-70 | |
| » Starters: Bill Kunkel vs Milt Pappas | Tenth | 33 out |
| Friday, August 11 |
| » Lost to White Sox (57-57), 1-0 | Comiskey Park I (1-6) | 42-71 | Lost 2 |
| » Starters: Jim Archer vs Billy Pierce | Tenth | 34 out |
| Saturday, August 12 |
| » Lost to White Sox (58-57), 2-1 | Comiskey Park I (1-7) | 42-72 | Lost 3 |
| » Starters: Bob Shaw vs Ray Herbert | Tenth | 34 out |
| Sunday, August 13 |
| » Lost to White Sox (59-57), 9-3 | Comiskey Park I (1-8) | 42-73 | Lost 4 |
| » Starters: Norm Bass vs Frank Baumann | Tenth | 34½ out |
| Monday, August 14 |
| » Lost to Twins (50-67), 6-2 | Metropolitan Stadium (2-5) | 42-74 | Lost 5 |
| » Starters: Jerry Walker vs Jim Kaat | Tenth | 35 out |
| Tuesday, August 15 |
| » Lost to Twins (51-67), 9-4 | Metropolitan Stadium (2-6) | 42-75 | Lost 6 |
| » Starters: Jim Archer vs Jack Kralick | Ninth | 35 out |
| Wednesday, August 16 |
| » Defeated Twins (51-68), 12-7 | Metropolitan Stadium (3-6) | 43-75 | |
| » Starters: Norm Bass vs Pedro Ramos | Tenth | 35 out |
| Thursday, August 17 |
| » Major-league debuts: Bill Dailey (Indians) |
| Friday, August 18 |
| » Defeated White Sox (60-60), 3-1 | Municipal Stadium (22-29) | 44-75 | Won 2 |
| » Starters: Ray Herbert vs Bob Shaw | Tenth | 34½ out |
| Saturday, August 19 |
| » Lost to White Sox (61-60), 5-3 | Municipal Stadium (22-30) | 44-76 | |
| » Starters: Cal McLish vs Jerry Walker | Ninth | 35½ out |
| Sunday, August 20 |
| » Lost to White Sox (62-60), 5-3 | Municipal Stadium (22-31) | 44-77 | Lost 2 |
| » Starters: Billy Pierce vs Jim Archer | Ninth | 37½ out |
| » Lost to White Sox (63-60), 7-0 | Municipal Stadium (22-32) | 44-78 | Lost 3 |
| » Starters: Juan Pizarro vs Art Ditmar | Ninth | 37½ out |
| Tuesday, August 22 |
| » Defeated Orioles (72-54), 3-2 | Municipal Stadium (23-32) | 45-78 | |
| » Starters: Milt Pappas vs Norm Bass | Ninth | 36½ out |
| Wednesday, August 23 |
| » Lost to Orioles (73-54), 7-5 | Municipal Stadium (23-33) | 45-79 | |
| » Starters: Hal Brown vs Bob Shaw | Ninth | 37½ out |
| Thursday, August 24 |
| » Defeated Orioles (73-55), 5-3 | Municipal Stadium (24-33) | 46-79 | |
| » Starters: Steve Barber vs Ed Rakow | Ninth | 36½ out |
| Friday, August 25 |
| » Lost to Yankees (84-43), 3-0 | Municipal Stadium (24-34) | 46-80 | |
| » Starters: Ralph Terry vs Jim Archer | Tenth | 37½ out |
| Saturday, August 26 |
| » Lost to Yankees (85-43), 5-1 | Municipal Stadium (24-35) | 46-81 | Lost 2 |
| » Starters: Bill Stafford vs Jerry Walker | Ninth | 38½ out |
| Future Athletic Jeff Parrett is born in Indianapolis, IN. |
| Sunday, August 27 |
| » Lost to Yankees (86-43), 8-7 | Municipal Stadium (24-36) | 46-82 | Lost 3 |
| » Starters: Whitey Ford vs Bob Shaw | Tenth | 39½ out |
| Monday, August 28 |
| » Lost to Red Sox (62-72), 4-3 | Municipal Stadium (24-37) | 46-83 | Lost 4 |
| » Starters: Bill Monbouquette vs Norm Bass | Tenth | 40 out |
| Tuesday, August 29 |
| » Lost to Red Sox (63-72), 8-4 | Municipal Stadium (24-38) | 46-84 | Lost 5 |
| » Starters: Ike Delock vs Ed Rakow | Tenth | 40 out |
| Wednesday, August 30 |
| » Lost to Red Sox (64-72), 9-3 | Municipal Stadium (24-39) | 46-85 | Lost 6 |
| » Starters: Gene Conley vs Jim Archer | Tenth | 41 out |
| Thursday, August 31 |
| » Defeated Angels (58-75), 17-3 | Wrigley Field (2-4) | 47-85 | |
| » Starters: Jerry Walker vs Ken McBride | Tenth | 39½ out |
| » Defeated Angels (58-76), 6-5 | Wrigley Field (3-4) | 48-85 | Won 2 |
| » Starters: Bob Shaw vs Ted Bowsfield | Tenth | 39½ out |
| Friday, September 1 |
| » Lost to Angels (59-76), 6-4 | Wrigley Field (3-5) | 48-86 | |
| » Starters: Norm Bass vs Eli Grba | Tenth | 40½ out |
| Saturday, September 2 |
| » Lost to Angels (60-76), 6-3 | Wrigley Field (3-6) | 48-87 | Lost 2 |
| » Starters: Ed Rakow vs Ken McBride | Tenth | 41½ out |
| Monday, September 4 |
| » Lost to Angels (61-76), 4-3 | Municipal Stadium (24-40) | 48-88 | Lost 3 |
| » Starters: Jack Spring vs Jim Archer | Tenth | 43 out |
| » Defeated Angels (61-77), 13-7 | Municipal Stadium (25-40) | 49-88 | |
| » Starters: Ted Bowsfield vs Bob Shaw | Tenth | 43 out |
| Tuesday, September 5 |
| » Defeated Angels (61-78), 7-3 | Municipal Stadium (26-40) | 50-88 | Won 2 |
| » Starters: Ryne Duren vs Jerry Walker | Tenth | 42½ out |
| » Defeated Angels (61-79), 13-12 | Municipal Stadium (27-40) | 51-88 | Won 3 |
| » Starters: Eli Grba vs Lew Krausse | Tenth | 42½ out |
| Friday, September 8 |
| » Defeated Twins (59-80), 6-4 | Municipal Stadium (28-40) | 52-88 | Won 4 |
| » Starters: Jim Kaat vs Jim Archer | Ninth | 43½ out |
| Saturday, September 9 |
| » Lost to Twins (60-80), 5-4 | Municipal Stadium (28-41) | 52-89 | |
| » Starters: Al Schroll vs Bob Shaw | Ninth | 44½ out |
| Sunday, September 10 |
| » Defeated Twins (60-81), 13-1 | Municipal Stadium (29-41) | 53-89 | |
| » Starters: Jack Kralick vs Norm Bass | Ninth | 45½ out |
| » Lost to Twins (61-81), 7-0 | Municipal Stadium (29-42) | 53-90 | |
| » Starters: Pedro Ramos vs Bill Kunkel | Ninth | 45½ out |
| Tuesday, September 12 |
| » Lost to Tigers (88-56), 3-1 | Tiger Stadium (2-5) | 53-91 | Lost 2 |
| » Starters: Jerry Walker vs Frank Lary | Ninth | 46½ out |
| Wednesday, September 13 |
| » Lost to Tigers (89-56), 8-0 | Tiger Stadium (2-6) | 53-92 | Lost 3 |
| » Starters: Jim Archer vs Jim Bunning | Tenth | 47 out |
| Thursday, September 14 |
| » Defeated Tigers (89-57), 5-2 | Tiger Stadium (3-6) | 54-92 | |
| » Starters: Bob Shaw vs Paul Foytack | Ninth | 45½ out |
| Friday, September 15 |
| » Lost to Senators (55-93), 3-1 | Griffith Stadium (4-3) | 54-93 | |
| » Starters: Norm Bass vs Bennie Daniels | Tenth | 46 out |
| Saturday, September 16 |
| » Lost to Senators (56-93), 3-0 | Griffith Stadium (4-4) | 54-94 | Lost 2 |
| » Starters: Jerry Walker vs Pete Burnside | Tenth | 46 out |
| Sunday, September 17 |
| » Defeated Senators (56-94), 3-2 | Griffith Stadium (5-4) | 55-94 | |
| » Starters: Lew Krausse vs Hector Maestri | Tenth | 46 out |
| Tuesday, September 19 |
| » Defeated Indians (73-78), 6-0 | Cleveland Stadium (4-3) | 56-94 | Won 2 |
| » Starters: Jim Archer vs Dick Stigman | Ninth | 46 out |
| » Lost to Indians (74-78), 6-2 | Cleveland Stadium (4-4) | 56-95 | |
| » Starters: Bob Shaw vs Gary Bell | Ninth | 46 out |
| Wednesday, September 20 |
| » Defeated Indians (74-79), 4-2 | Cleveland Stadium (5-4) | 57-95 | |
| » Starters: Norm Bass vs Barry Latman | Ninth | 46 out |
| Friday, September 22 |
| » Defeated Indians (74-80), 4-3 | Municipal Stadium (30-42) | 58-95 | Won 2 |
| » Starters: Jim Perry vs Jerry Walker | Ninth | 45 out |
| Saturday, September 23 |
| » Lost to Indians (75-80), 9-5 | Municipal Stadium (30-43) | 58-96 | |
| » Starters: Mudcat Grant vs Bill Kirk | Ninth | 46 out |
| Monday, September 25 |
| » Lost to Tigers (97-59), 6-4 | Municipal Stadium (30-44) | 58-97 | Lost 2 |
| » Starters: Don Mossi vs Jim Archer | Ninth | 45½ out |
| » Defeated Tigers (97-60), 6-3 | Municipal Stadium (31-44) | 59-97 | |
| » Starters: Ron Kline vs Bob Shaw | Ninth | 45½ out |
| Tuesday, September 26 |
| » Defeated Tigers (97-61), 8-5 | Municipal Stadium (32-44) | 60-97 | Won 2 |
| » Starters: Ron Nischwitz vs Norm Bass | Ninth | 45½ out |
| » Major-league debuts: Bill Freehan (Tigers) |
| Wednesday, September 27 |
| » Lost to Tigers (98-61), 10-2 | Municipal Stadium (32-45) | 60-98 | |
| » Starters: Frank Lary vs Jerry Walker | Ninth | 45½ out |
| Thursday, September 28 |
| Future Athletic Ed Vosberg is born in Tucson, AZ. |
| Friday, September 29 |
| » Lost to Senators (60-99), 2-0 | Municipal Stadium (32-46) | 60-99 | Lost 2 |
| » Starters: Pete Burnside vs Jim Archer | Ninth | 46½ out |
| Saturday, September 30 |
| » Lost to Senators (61-99), 5-4 | Municipal Stadium (32-47) | 60-100 | Lost 3 |
| » Starters: Bennie Daniels vs Bob Shaw | Tenth | 47½ out |
| Sunday, October 1 |
| » Defeated Senators (61-100), 3-2 | Municipal Stadium (33-47) | 61-100 | |
| » Starters: Claude Osteen vs Norm Bass | Ninth | 47½ out |
| Monday, October 16 |
| Future Athletic Billy Taylor is born in Monticello, FL. |
| Sunday, November 5 |
| Future Athletic Fred Manrique is born in Edo Bolivar, Venezuela. |
| Tuesday, November 7 |
| Future Athletic Orlando Mercado is born in Arecibo, P.R. |
| Thursday, November 23 |
| Former Athletic Nick Carter dies in Grasonville, MD at the age of 83. |
| Tuesday, December 26 |
| Future Athletic Storm Davis is born in Dallas, TX. |
Game information provided by Retrosheet (www.retrosheet.org) |