| Saturday, January 14 |
| Future Angel Joe Redfield is born in Doylestown, PA. |
| Sunday, January 29 |
| Future Angel Mike Aldrete is born in Carmel, CA. |
| Thursday, February 23 |
| Future Angel John Morris is born in North Bellmore, NY. |
| Sunday, April 9 |
| Future Angel Brian Dorsett is born in Terre Haute, IN. Future Angel Kirk McCaskill is born in Kapuskasing, ON. |
| Tuesday, April 11 |
| » Defeated Orioles (0-1), 7-2 | Memorial Stadium (1-0) | 1-0 | |
| » Starters: Eli Grba vs Milt Pappas | First | -- |
| Saturday, April 15 |
| » Lost to Red Sox (1-1), 3-0 | Fenway Park (0-1) | 1-1 | |
| » Starters: Jerry Casale vs Ike Delock | Second | ½ out |
| Sunday, April 16 |
| » Major-league debuts: Bill Pleis (Twins) |
| Monday, April 17 |
| » Lost to Red Sox (2-1), 3-2 | Fenway Park (0-2) | 1-2 | Lost 2 |
| » Starters: Ken McBride vs Tom Brewer | Fourth | 2 out |
| Wednesday, April 19 |
| » Major-league debuts: Ed Hobaugh (Senators) |
| Future Angel Spike Owen is born in Cleburne, TX. |
| Thursday, April 20 |
| » Lost to Yankees (3-1), 7-5 | Yankee Stadium (0-1) | 1-3 | Lost 3 |
| » Starters: Eli Grba vs Art Ditmar | Eighth | 3½ out |
| » Lost to Yankees (4-1), 4-2 | Yankee Stadium (0-2) | 1-4 | Lost 4 |
| » Starters: Ned Garver vs Bob Turley | Eighth | 3½ out |
| Friday, April 21 |
| » Lost to Tigers (5-1), 9-1 | Tiger Stadium (0-1) | 1-5 | Lost 5 |
| » Starters: Jerry Casale vs Don Mossi | Eighth | 4 out |
| Saturday, April 22 |
| » Major-league debuts: Lee Thomas (Yankees) |
| Sunday, April 23 |
| » Lost to Tigers (6-1), 3-1 | Tiger Stadium (0-2) | 1-6 | Lost 6 |
| » Starters: Ken McBride vs Bob Bruce | Tenth | 6 out |
| » Lost to Tigers (7-1), 3-2 | Tiger Stadium (0-3) | 1-7 | Lost 7 |
| » Starters: Ron Kline vs Jim Bunning | Tenth | 6 out |
| Thursday, April 27 |
| » Lost to Twins (9-3), 4-2 | Wrigley Field (0-1) | 1-8 | Lost 8 |
| » Starters: Camilo Pascual vs Eli Grba | Tenth | 6½ out |
| Friday, April 28 |
| » Defeated Twins (9-4), 6-5 | Wrigley Field (1-1) | 2-8 | |
| » Starters: Pedro Ramos vs Ron Kline | Ninth | 5½ out |
| Saturday, April 29 |
| » Defeated Twins (9-5), 4-1 | Wrigley Field (2-1) | 3-8 | Won 2 |
| » Starters: Jim Kaat vs Ken McBride | Eighth | 5½ out |
| Sunday, April 30 |
| » Defeated Athletics (4-8), 6-4 | Wrigley Field (3-1) | 4-8 | Won 3 |
| » Starters: Joe Nuxhall vs Ron Moeller | Ninth | 5½ out |
| » Lost to Athletics (5-8), 3-2 | Wrigley Field (3-2) | 4-9 | |
| » Starters: Jim Archer vs Jerry Casale | Ninth | 5½ out |
| » Major-league debuts: Jim Archer (Athletics) |
| Tuesday, May 2 |
| » Lost to Orioles (9-8), 7-6 | Wrigley Field (3-3) | 4-10 | Lost 2 |
| » Starters: Dick Hall vs Eli Grba | Eighth | 6½ out |
| Wednesday, May 3 |
| » Defeated Orioles (9-9), 7-6 | Wrigley Field (4-3) | 5-10 | |
| » Starters: Chuck Estrada vs Ron Kline | Sixth | 5½ out |
| Thursday, May 4 |
| » Lost to Orioles (10-9), 8-7 | Wrigley Field (4-4) | 5-11 | |
| » Starters: Milt Pappas vs Ken McBride | Seventh | 6½ out |
| Friday, May 5 |
| » Lost to Yankees (13-5), 5-4 | Wrigley Field (4-5) | 5-12 | Lost 2 |
| » Starters: Ralph Terry vs Ron Moeller | Seventh | 7½ out |
| Saturday, May 6 |
| » Defeated Yankees (13-6), 5-3 | Wrigley Field (5-5) | 6-12 | |
| » Starters: Art Ditmar vs Eli Grba | Ninth | 7½ out |
| Sunday, May 7 |
| » Defeated Yankees (13-7), 5-3 | Wrigley Field (6-5) | 7-12 | Won 2 |
| » Starters: Bob Turley vs Ron Kline | Sixth | 8 out |
| Monday, May 8 |
| » Defeated Red Sox (8-11), 6-5 | Wrigley Field (7-5) | 8-12 | Won 3 |
| » Starters: Gene Conley vs Ken McBride | Sixth | 7½ out |
| Tuesday, May 9 |
| » Defeated Red Sox (8-12), 8-7 | Wrigley Field (8-5) | 9-12 | Won 4 |
| » Starters: Ike Delock vs Jerry Casale | Sixth | 7 out |
| Wednesday, May 10 |
| » Lost to Red Sox (9-12), 3-2 | Wrigley Field (8-6) | 9-13 | |
| » Starters: Tom Brewer vs Ron Moeller | Sixth | 8 out |
| Friday, May 12 |
| » Lost to Twins (13-12), 5-4 | Metropolitan Stadium (0-1) | 9-14 | Lost 2 |
| » Starters: Eli Grba vs Pedro Ramos | Eighth | 8½ out |
| Saturday, May 13 |
| » Lost to Twins (14-12), 13-6 | Metropolitan Stadium (0-2) | 9-15 | Lost 3 |
| » Starters: Ron Kline vs Don Lee | Tenth | 9½ out |
| Sunday, May 14 |
| » Lost to Twins (15-12), 4-3 | Metropolitan Stadium (0-3) | 9-16 | Lost 4 |
| » Starters: Ken McBride vs Jack Kralick | Tenth | 9 out |
| Monday, May 15 |
| » Lost to Athletics (11-13), 5-3 | Municipal Stadium (0-1) | 9-17 | Lost 5 |
| » Starters: Ron Moeller vs Bud Daley | Tenth | 10 out |
| Tuesday, May 16 |
| » Lost to Athletics (12-13), 6-4 | Municipal Stadium (0-2) | 9-18 | Lost 6 |
| » Starters: Eli Grba vs Norm Bass | Tenth | 11 out |
| Thursday, May 18 |
| » Lost to White Sox (13-16), 6-4 | Wrigley Field (8-7) | 9-19 | Lost 7 |
| » Starters: Billy Pierce vs Ron Kline | Ninth | 11½ out |
| Friday, May 19 |
| » Defeated White Sox (13-17), 4-3 | Wrigley Field (9-7) | 10-19 | |
| » Starters: Herb Score vs Jerry Casale | Ninth | 10½ out |
| » Defeated White Sox (13-18), 5-3 | Wrigley Field (10-7) | 11-19 | Won 2 |
| » Starters: Bob Shaw vs Ken McBride | Ninth | 10½ out |
| Sunday, May 21 |
| » Lost to Senators (16-19), 6-2 | Wrigley Field (10-8) | 11-20 | |
| » Starters: Bennie Daniels vs Ron Moeller | Tenth | 11½ out |
| » Lost to Senators (17-19), 7-2 | Wrigley Field (10-9) | 11-21 | Lost 2 |
| » Starters: Hal Woodeshick vs Ron Kline | Tenth | 11½ out |
| Monday, May 22 |
| » Defeated Senators (17-20), 6-4 | Wrigley Field (11-9) | 12-21 | |
| » Starters: Pete Burnside vs Eli Grba | Tenth | 11½ out |
| Tuesday, May 23 |
| » Defeated Indians (21-15), 9-0 | Wrigley Field (12-9) | 13-21 | Won 2 |
| » Starters: Jim Perry vs Ken McBride | Tenth | 11½ out |
| Wednesday, May 24 |
| » Lost to Indians (22-15), 7-1 | Wrigley Field (12-10) | 13-22 | |
| » Starters: Gary Bell vs Jerry Casale | Tenth | 12½ out |
| Thursday, May 25 |
| » Lost to Indians (23-15), 13-5 | Wrigley Field (12-11) | 13-23 | Lost 2 |
| » Starters: Mudcat Grant vs Ron Moeller | Tenth | 12½ out |
| Friday, May 26 |
| » Defeated Tigers (27-13), 5-4 | Wrigley Field (13-11) | 14-23 | |
| » Starters: Frank Lary vs Ron Kline | Ninth | 11½ out |
| Saturday, May 27 |
| » Defeated Tigers (27-14), 10-1 | Wrigley Field (14-11) | 15-23 | Won 2 |
| » Starters: Phil Regan vs Ken McBride | Ninth | 10½ out |
| Sunday, May 28 |
| » Lost to Tigers (28-14), 9-4 | Wrigley Field (14-12) | 15-24 | |
| » Starters: Jim Bunning vs Art Fowler | Ninth | 11½ out |
| Tuesday, May 30 |
| » Lost to Senators (22-22), 5-1 | Griffith Stadium (0-1) | 15-25 | Lost 2 |
| » Starters: Ned Garver vs Ed Hobaugh | Ninth | 12 out |
| Wednesday, May 31 |
| » Defeated Senators (22-23), 5-3 | Griffith Stadium (1-1) | 16-25 | |
| » Starters: Ron Moeller vs Tom Sturdivant | Ninth | 11 out |
| Thursday, June 1 |
| » Lost to Senators (23-23), 3-2 | Griffith Stadium (1-2) | 16-26 | |
| » Starters: Eli Grba vs Joe McClain | Ninth | 11½ out |
| Friday, June 2 |
| » Lost to Indians (27-17), 6-4 | Cleveland Stadium (0-1) | 16-27 | Lost 2 |
| » Starters: Ken McBride vs Gary Bell | Ninth | 12½ out |
| Saturday, June 3 |
| » Lost to Indians (28-17), 9-4 | Cleveland Stadium (0-2) | 16-28 | Lost 3 |
| » Starters: Art Fowler vs Mudcat Grant | Tenth | 13½ out |
| Sunday, June 4 |
| » Lost to Indians (29-17), 5-3 | Cleveland Stadium (0-3) | 16-29 | Lost 4 |
| » Starters: Ron Kline vs Jim Perry | Tenth | 15½ out |
| » Lost to Indians (30-17), 8-4 | Cleveland Stadium (0-4) | 16-30 | Lost 5 |
| » Starters: Jerry Casale vs Wynn Hawkins | Tenth | 15½ out |
| Monday, June 5 |
| » Defeated Orioles (26-23), 3-0 | Memorial Stadium (2-0) | 17-30 | |
| » Starters: Ron Moeller vs Hal Brown | Tenth | 14½ out |
| Tuesday, June 6 |
| » Defeated Orioles (26-24), 7-3 | Memorial Stadium (3-0) | 18-30 | Won 2 |
| » Starters: Eli Grba vs Milt Pappas | Tenth | 14 out |
| » Lost to Orioles (27-24), 2-0 | Memorial Stadium (3-1) | 18-31 | |
| » Starters: Ken McBride vs Chuck Estrada | Tenth | 14 out |
| Wednesday, June 7 |
| » Defeated Orioles (27-25), 4-0 | Memorial Stadium (4-1) | 19-31 | |
| » Starters: Ted Bowsfield vs Billy Hoeft | Ninth | 14 out |
| Thursday, June 8 |
| » Lost to Red Sox (24-25), 6-5 | Fenway Park (0-3) | 19-32 | |
| » Starters: Ron Kline vs Ike Delock | Tenth | 14½ out |
| » Tied Red Sox, 4-4 | Fenway Park (0-3) | 19-32 | |
| » Starters: Johnny James vs Gene Conley | Tenth | 14½ out |
| Future Angel Kevin Gross is born in Downey, CA. |
| Friday, June 9 |
| » Lost to Red Sox (25-25), 5-3 | Fenway Park (0-4) | 19-33 | Lost 2 |
| » Starters: Art Fowler vs Billy Muffett | Tenth | 15 out |
| » Defeated Red Sox (25-26), 5-1 | Fenway Park (1-4) | 20-33 | |
| » Starters: Ryne Duren vs Mike Fornieles | Tenth | 15 out |
| Saturday, June 10 |
| » Defeated Red Sox (25-27), 10-5 | Fenway Park (2-4) | 21-33 | Won 2 |
| » Starters: Ron Moeller vs Bill Monbouquette | Eighth | 14 out |
| Sunday, June 11 |
| » Lost to Yankees (33-20), 2-1 | Yankee Stadium (0-3) | 21-34 | |
| » Starters: Ken McBride vs Ralph Terry | Tenth | 16 out |
| » Lost to Yankees (34-20), 5-1 | Yankee Stadium (0-4) | 21-35 | Lost 2 |
| » Starters: Eli Grba vs Rollie Sheldon | Tenth | 16 out |
| Monday, June 12 |
| » Lost to Yankees (35-20), 3-1 | Yankee Stadium (0-5) | 21-36 | Lost 3 |
| » Starters: Ted Bowsfield vs Bill Stafford | Tenth | 16 out |
| Tuesday, June 13 |
| » Lost to White Sox (22-33), 2-1 | Comiskey Park I (0-1) | 21-37 | Lost 4 |
| » Starters: Ryne Duren vs Cal McLish | Tenth | 17½ out |
| » Lost to White Sox (23-33), 10-2 | Comiskey Park I (0-2) | 21-38 | Lost 5 |
| » Starters: Ron Kline vs Juan Pizarro | Tenth | 17½ out |
| Wednesday, June 14 |
| » Lost to White Sox (24-33), 4-1 | Comiskey Park I (0-3) | 21-39 | Lost 6 |
| » Starters: Johnny James vs Ray Herbert | Ninth | 18 out |
| » Lost to White Sox (25-33), 9-8 | Comiskey Park I (0-4) | 21-40 | Lost 7 |
| » Starters: Ron Moeller vs Frank Baumann | Ninth | 18 out |
| Thursday, June 15 |
| » Lost to White Sox (26-33), 3-2 | Comiskey Park I (0-5) | 21-41 | Lost 8 |
| » Starters: Eli Grba vs Billy Pierce | Eighth | 18 out |
| Friday, June 16 |
| » Lost to Athletics (26-31), 4-0 | Municipal Stadium (0-3) | 21-42 | Lost 9 |
| » Starters: Ken McBride vs Lew Krausse | Eighth | 19 out |
| Saturday, June 17 |
| » Defeated Athletics (26-32), 3-0 | Municipal Stadium (1-3) | 22-42 | |
| » Starters: Ted Bowsfield vs Bob Shaw | Tenth | 19 out |
| Sunday, June 18 |
| » Defeated Athletics (26-33), 5-3 | Municipal Stadium (2-3) | 23-42 | Won 2 |
| » Starters: Ryne Duren vs Norm Bass | Tenth | 18 out |
| Tuesday, June 20 |
| » Lost to Red Sox (33-30), 11-8 | Wrigley Field (14-13) | 23-43 | |
| » Starters: Bill Monbouquette vs Eli Grba | Tenth | 19 out |
| Wednesday, June 21 |
| » Defeated Red Sox (33-31), 5-1 | Wrigley Field (15-13) | 24-43 | |
| » Starters: Don Schwall vs Ken McBride | Tenth | 18½ out |
| Thursday, June 22 |
| » Lost to Red Sox (34-31), 3-2 | Wrigley Field (15-14) | 24-44 | |
| » Starters: Galen Cisco vs Ryne Duren | Tenth | 19½ out |
| Friday, June 23 |
| » Lost to Orioles (35-33), 8-6 | Wrigley Field (15-15) | 24-45 | Lost 2 |
| » Starters: Steve Barber vs Ted Bowsfield | Tenth | 20½ out |
| Saturday, June 24 |
| » Defeated Orioles (35-34), 4-1 | Wrigley Field (16-15) | 25-45 | |
| » Starters: Dick Hall vs Ron Moeller | Tenth | 20½ out |
| Sunday, June 25 |
| » Lost to Orioles (36-34), 9-8 | Wrigley Field (16-16) | 25-46 | |
| » Starters: Hal Brown vs Eli Grba | Ninth | 21 out |
| Monday, June 26 |
| » Lost to Yankees (44-25), 8-6 | Wrigley Field (16-17) | 25-47 | Lost 2 |
| » Starters: Whitey Ford vs Ken McBride | Ninth | 21½ out |
| Tuesday, June 27 |
| » Defeated Yankees (44-26), 7-6 | Wrigley Field (17-17) | 26-47 | |
| » Starters: Bud Daley vs Ted Bowsfield | Ninth | 20 out |
| Wednesday, June 28 |
| » Defeated Yankees (44-27), 5-3 | Wrigley Field (18-17) | 27-47 | Won 2 |
| » Starters: Bob Turley vs Ryne Duren | Tenth | 20 out |
| Friday, June 30 |
| » Defeated White Sox (38-37), 10-3 | Wrigley Field (19-17) | 28-47 | Won 3 |
| » Starters: Billy Pierce vs Ken McBride | Tenth | 20½ out |
| Saturday, July 1 |
| » Lost to White Sox (39-37), 6-4 | Wrigley Field (19-18) | 28-48 | |
| » Starters: Early Wynn vs Eli Grba | Tenth | 21½ out |
| Sunday, July 2 |
| » Defeated White Sox (39-38), 8-3 | Wrigley Field (20-18) | 29-48 | |
| » Starters: Juan Pizarro vs Johnny James | Tenth | 20½ out |
| Monday, July 3 |
| » Defeated Athletics (30-45), 5-3 | Wrigley Field (21-18) | 30-48 | Won 2 |
| » Starters: Jim Archer vs Ryne Duren | Tenth | 20 out |
| Tuesday, July 4 |
| » Defeated Athletics (30-46), 12-5 | Wrigley Field (22-18) | 31-48 | Won 3 |
| » Starters: Lew Krausse vs Ted Bowsfield | Ninth | 19 out |
| » Defeated Athletics (30-47), 7-5 | Wrigley Field (23-18) | 32-48 | Won 4 |
| » Starters: Joe Nuxhall vs Ken McBride | Ninth | 19 out |
| Wednesday, July 5 |
| » Defeated Twins (33-47), 6-2 | Metropolitan Stadium (1-3) | 33-48 | Won 5 |
| » Starters: Eli Grba vs Jim Kaat | Ninth | 18½ out |
| Thursday, July 6 |
| » Defeated Twins (33-48), 12-11 | Metropolitan Stadium (2-3) | 34-48 | Won 6 |
| » Starters: Ryne Duren vs Gerry Arrigo | Eighth | 18½ out |
| Friday, July 7 |
| » Defeated Tigers (52-30), 4-2 | Tiger Stadium (1-3) | 35-48 | Won 7 |
| » Starters: Ken McBride vs Hal Woodeshick | Seventh | 18 out |
| Saturday, July 8 |
| » Lost to Tigers (53-30), 3-2 | Tiger Stadium (1-4) | 35-49 | |
| » Starters: Ted Bowsfield vs Don Mossi | Seventh | 19 out |
| Sunday, July 9 |
| » Lost to Tigers (54-30), 1-0 | Tiger Stadium (1-5) | 35-50 | Lost 2 |
| » Starters: Eli Grba vs Frank Lary | Eighth | 20½ out |
| » Lost to Tigers (55-30), 6-3 | Tiger Stadium (1-6) | 35-51 | Lost 3 |
| » Starters: Ryne Duren vs Jim Bunning | Eighth | 20½ out |
| Friday, July 14 |
| » Lost to Indians (48-40), 7-5 | Cleveland Stadium (0-5) | 35-52 | Lost 4 |
| » Starters: Ken McBride vs Barry Latman | Ninth | 20½ out |
| Saturday, July 15 |
| » Defeated Indians (48-41), 6-5 | Cleveland Stadium (1-5) | 36-52 | |
| » Starters: Eli Grba vs Jim Perry | Ninth | 20½ out |
| Sunday, July 16 |
| » Defeated Senators (39-49), 11-2 | Griffith Stadium (2-2) | 37-52 | Won 2 |
| » Starters: Ted Bowsfield vs Ed Hobaugh | Ninth | 21½ out |
| » Lost to Senators (40-49), 4-3 | Griffith Stadium (2-3) | 37-53 | |
| » Starters: Ron Moeller vs Tom Cheney | Ninth | 21½ out |
| Tuesday, July 18 |
| » Defeated Twins (37-53), 4-1 | Wrigley Field (24-18) | 38-53 | |
| » Starters: Pedro Ramos vs Ken McBride | Eighth | 21½ out |
| Wednesday, July 19 |
| » Lost to Twins (38-53), 6-0 | Wrigley Field (24-19) | 38-54 | |
| » Starters: Camilo Pascual vs Eli Grba | Eighth | 20½ out |
| » Defeated Twins (38-54), 2-1 | Wrigley Field (25-19) | 39-54 | |
| » Starters: Jack Kralick vs Jim Donohue | Eighth | 20½ out |
| Friday, July 21 |
| » Defeated Senators (42-51), 16-5 | Wrigley Field (26-19) | 40-54 | Won 2 |
| » Starters: Ed Hobaugh vs Ron Moeller | Eighth | 20½ out |
| Saturday, July 22 |
| » Defeated Senators (42-52), 7-6 | Wrigley Field (27-19) | 41-54 | Won 3 |
| » Starters: Tom Cheney vs Ken McBride | Eighth | 20½ out |
| Sunday, July 23 |
| » Defeated Senators (42-53), 8-3 | Wrigley Field (28-19) | 42-54 | Won 4 |
| » Starters: Joe McClain vs Ted Bowsfield | Eighth | 20 out |
| Future Angel Chuck Crim is born in Van Nuys, CA. |
| Monday, July 24 |
| » Lost to Tigers (63-34), 5-2 | Wrigley Field (28-20) | 42-55 | |
| » Starters: Jim Bunning vs Jim Donohue | Eighth | 21 out |
| Tuesday, July 25 |
| » Defeated Tigers (63-35), 5-4 | Wrigley Field (29-20) | 43-55 | |
| » Starters: Don Mossi vs Ken McBride | Eighth | 20½ out |
| Wednesday, July 26 |
| » Lost to Tigers (64-35), 5-4 | Wrigley Field (29-21) | 43-56 | |
| » Starters: Frank Lary vs Ron Moeller | Eighth | 21½ out |
| Friday, July 28 |
| » Defeated Indians (54-48), 8-5 | Wrigley Field (30-21) | 44-56 | |
| » Starters: Barry Latman vs Jim Donohue | Eighth | 21 out |
| Saturday, July 29 |
| » Lost to Indians (55-48), 8-3 | Wrigley Field (30-22) | 44-57 | |
| » Starters: Jim Perry vs Ken McBride | Eighth | 22 out |
| Sunday, July 30 |
| » Defeated Indians (55-49), 8-6 | Wrigley Field (31-22) | 45-57 | |
| » Starters: Gary Bell vs Ted Bowsfield | Eighth | 20½ out |
| Wednesday, August 2 |
| » Lost to Red Sox (48-58), 7-2 | Fenway Park (2-5) | 45-58 | |
| » Starters: Jim Donohue vs Ike Delock | Eighth | 22½ out |
| » Lost to Red Sox (49-58), 8-7 | Fenway Park (2-6) | 45-59 | Lost 2 |
| » Starters: Ron Moeller vs Tracy Stallard | Eighth | 22½ out |
| Thursday, August 3 |
| » Lost to Red Sox (50-58), 4-0 | Fenway Park (2-7) | 45-60 | Lost 3 |
| » Starters: Ken McBride vs Don Schwall | Eighth | 22½ out |
| Friday, August 4 |
| » Defeated Orioles (60-48), 3-1 | Memorial Stadium (5-1) | 46-60 | |
| » Starters: Ted Bowsfield vs Steve Barber | Ninth | 23 out |
| » Lost to Orioles (61-48), 3-0 | Memorial Stadium (5-2) | 46-61 | |
| » Starters: Eli Grba vs Jack Fisher | Ninth | 23 out |
| Saturday, August 5 |
| » Defeated Orioles (61-49), 4-2 | Memorial Stadium (6-2) | 47-61 | |
| » Starters: Ron Kline vs Milt Pappas | Eighth | 23 out |
| Monday, August 7 |
| » Lost to Yankees (72-37), 4-1 | Yankee Stadium (0-6) | 47-62 | |
| » Starters: Ken McBride vs Bud Daley | Seventh | 25 out |
| Tuesday, August 8 |
| » Lost to Yankees (73-37), 5-4 | Yankee Stadium (0-7) | 47-63 | Lost 2 |
| » Starters: Eli Grba vs Bill Stafford | Seventh | 26 out |
| Wednesday, August 9 |
| » Lost to Yankees (74-37), 2-0 | Yankee Stadium (0-8) | 47-64 | Lost 3 |
| » Starters: Ted Bowsfield vs Jim Coates | Seventh | 27 out |
| Thursday, August 10 |
| » Lost to Yankees (75-37), 3-1 | Yankee Stadium (0-9) | 47-65 | Lost 4 |
| » Starters: Jim Donohue vs Whitey Ford | Eighth | 28 out |
| Friday, August 11 |
| » Lost to Indians (60-54), 3-2 | Cleveland Stadium (1-6) | 47-66 | Lost 5 |
| » Starters: Ken McBride vs Jim Perry | Ninth | 29 out |
| Saturday, August 12 |
| » Defeated Indians (60-55), 3-0 | Cleveland Stadium (2-6) | 48-66 | |
| » Starters: Ryne Duren vs Mudcat Grant | Eighth | 28 out |
| Sunday, August 13 |
| » Defeated Indians (60-56), 8-7 | Cleveland Stadium (3-6) | 49-66 | Won 2 |
| » Starters: Eli Grba vs Barry Latman | Seventh | 27½ out |
| Monday, August 14 |
| » Defeated Senators (48-66), 5-1 | Griffith Stadium (3-3) | 50-66 | Won 3 |
| » Starters: Ted Bowsfield vs Gabe Gabler | Seventh | 27 out |
| Tuesday, August 15 |
| » Defeated Senators (48-67), 8-7 | Griffith Stadium (4-3) | 51-66 | Won 4 |
| » Starters: Jim Donohue vs Pete Burnside | Sixth | 26 out |
| Wednesday, August 16 |
| » Lost to Senators (49-67), 3-2 | Griffith Stadium (4-4) | 51-67 | |
| » Starters: Ken McBride vs Dick Donovan | Seventh | 27 out |
| Thursday, August 17 |
| » Lost to Senators (50-67), 4-3 | Griffith Stadium (4-5) | 51-68 | Lost 2 |
| » Starters: Ryne Duren vs Bennie Daniels | Seventh | 28 out |
| Friday, August 18 |
| » Defeated Twins (51-69), 5-2 | Wrigley Field (32-22) | 52-68 | |
| » Starters: Camilo Pascual vs Eli Grba | Seventh | 27 out |
| Future Angel Jack Howell is born in Tucson, AZ. |
| Saturday, August 19 |
| » Lost to Twins (52-69), 5-3 | Wrigley Field (32-23) | 52-69 | |
| » Starters: Jim Kaat vs Ted Bowsfield | Seventh | 28 out |
| Sunday, August 20 |
| » Lost to Twins (53-69), 9-7 | Wrigley Field (32-24) | 52-70 | Lost 2 |
| » Starters: Jack Kralick vs Jim Donohue | Seventh | 29½ out |
| Tuesday, August 22 |
| » Defeated Yankees (82-42), 4-3 | Wrigley Field (33-24) | 53-70 | |
| » Starters: Bill Stafford vs Ken McBride | Seventh | 28½ out |
| Wednesday, August 23 |
| » Lost to Yankees (83-42), 8-6 | Wrigley Field (33-25) | 53-71 | |
| » Starters: Whitey Ford vs Ryne Duren | Seventh | 29½ out |
| Thursday, August 24 |
| » Defeated Yankees (83-43), 6-4 | Wrigley Field (34-25) | 54-71 | |
| » Starters: Jim Coates vs Ted Bowsfield | Seventh | 28½ out |
| Friday, August 25 |
| » Lost to Red Sox (61-70), 12-6 | Wrigley Field (34-26) | 54-72 | |
| » Starters: Gene Conley vs Ron Moeller | Eighth | 29½ out |
| Saturday, August 26 |
| » Defeated Red Sox (61-71), 5-2 | Wrigley Field (35-26) | 55-72 | |
| » Starters: Tracy Stallard vs Ken McBride | Seventh | 29½ out |
| Sunday, August 27 |
| » Defeated Red Sox (61-72), 8-3 | Wrigley Field (36-26) | 56-72 | Won 2 |
| » Starters: Don Schwall vs Eli Grba | Seventh | 29½ out |
| Monday, August 28 |
| » Lost to Orioles (77-55), 8-1 | Wrigley Field (36-27) | 56-73 | |
| » Starters: Hal Brown vs Ted Bowsfield | Seventh | 30 out |
| Tuesday, August 29 |
| » Defeated Orioles (77-56), 6-5 | Wrigley Field (37-27) | 57-73 | |
| » Starters: Steve Barber vs Ryne Duren | Seventh | 28½ out |
| » Defeated Orioles (77-57), 6-5 | Wrigley Field (38-27) | 58-73 | Won 2 |
| » Starters: Billy Hoeft vs Jack Spring | Seventh | 28½ out |
| Wednesday, August 30 |
| » Lost to Orioles (78-57), 11-4 | Wrigley Field (38-28) | 58-74 | |
| » Starters: Jack Fisher vs Ron Moeller | Seventh | 29½ out |
| Thursday, August 31 |
| » Lost to Athletics (47-85), 17-3 | Wrigley Field (38-29) | 58-75 | Lost 2 |
| » Starters: Jerry Walker vs Ken McBride | Eighth | 30 out |
| » Lost to Athletics (48-85), 6-5 | Wrigley Field (38-30) | 58-76 | Lost 3 |
| » Starters: Bob Shaw vs Ted Bowsfield | Eighth | 30 out |
| Friday, September 1 |
| » Defeated Athletics (48-86), 6-4 | Wrigley Field (39-30) | 59-76 | |
| » Starters: Norm Bass vs Eli Grba | Eighth | 30 out |
| Saturday, September 2 |
| » Defeated Athletics (48-87), 6-3 | Wrigley Field (40-30) | 60-76 | Won 2 |
| » Starters: Ed Rakow vs Ken McBride | Seventh | 30 out |
| Monday, September 4 |
| » Defeated Athletics (48-88), 4-3 | Municipal Stadium (3-3) | 61-76 | Won 3 |
| » Starters: Jack Spring vs Jim Archer | Seventh | 31½ out |
| » Lost to Athletics (49-88), 13-7 | Municipal Stadium (3-4) | 61-77 | |
| » Starters: Ted Bowsfield vs Bob Shaw | Seventh | 31½ out |
| Tuesday, September 5 |
| » Lost to Athletics (50-88), 7-3 | Municipal Stadium (3-5) | 61-78 | Lost 2 |
| » Starters: Ryne Duren vs Jerry Walker | Seventh | 33 out |
| » Lost to Athletics (51-88), 13-12 | Municipal Stadium (3-6) | 61-79 | Lost 3 |
| » Starters: Eli Grba vs Lew Krausse | Seventh | 33 out |
| Friday, September 8 |
| » Lost to White Sox (78-65), 5-3 | Wrigley Field (40-31) | 61-80 | Lost 4 |
| » Starters: Ray Herbert vs Ken McBride | Seventh | 35 out |
| Saturday, September 9 |
| » Defeated White Sox (78-66), 6-2 | Wrigley Field (41-31) | 62-80 | |
| » Starters: Joe Horlen vs Eli Grba | Seventh | 35 out |
| Sunday, September 10 |
| » Defeated White Sox (78-67), 4-3 | Wrigley Field (42-31) | 63-80 | Won 2 |
| » Starters: Juan Pizarro vs Jack Spring | Seventh | 35½ out |
| Monday, September 11 |
| » Lost to Twins (62-81), 5-2 | Metropolitan Stadium (2-4) | 63-81 | |
| » Starters: Dean Chance vs Camilo Pascual | Seventh | 36 out |
| » Major-league debuts: Dean Chance (Angels) |
| Thursday, September 14 |
| » Defeated Twins (62-82), 5-1 | Metropolitan Stadium (3-4) | 64-81 | |
| » Starters: Ted Bowsfield vs Don Lee | Seventh | 35½ out |
| » Lost to Twins (63-82), 3-1 | Metropolitan Stadium (3-5) | 64-82 | |
| » Starters: Ken McBride vs Jim Kaat | Seventh | 35½ out |
| » Major-league debuts: Jim Fregosi (Angels) |
| Friday, September 15 |
| » Defeated White Sox (80-69), 9-5 | Comiskey Park I (1-5) | 65-82 | |
| » Starters: Eli Grba vs Joe Horlen | Seventh | 35 out |
| Saturday, September 16 |
| » Defeated White Sox (80-70), 11-4 | Comiskey Park I (2-5) | 66-82 | Won 2 |
| » Starters: Jack Spring vs Cal McLish | Seventh | 34 out |
| Sunday, September 17 |
| » Lost to White Sox (81-70), 8-1 | Comiskey Park I (2-6) | 66-83 | |
| » Starters: Dean Chance vs Frank Baumann | Eighth | 35½ out |
| » Lost to White Sox (82-70), 4-3 | Comiskey Park I (2-7) | 66-84 | Lost 2 |
| » Starters: Ron Moeller vs Billy Pierce | Eighth | 35½ out |
| Tuesday, September 19 |
| » Lost to Tigers (92-59), 6-2 | Tiger Stadium (1-7) | 66-85 | Lost 3 |
| » Starters: Ken McBride vs Don Mossi | Eighth | 36 out |
| Wednesday, September 20 |
| » Lost to Tigers (93-59), 6-3 | Tiger Stadium (1-8) | 66-86 | Lost 4 |
| » Starters: Ted Bowsfield vs Ron Kline | Eighth | 37 out |
| Friday, September 22 |
| » Lost to Tigers (94-59), 6-4 | Wrigley Field (42-32) | 66-87 | Lost 5 |
| » Starters: Frank Lary vs Eli Grba | Eighth | 37 out |
| Future Angel Vince Coleman is born in Jacksonville, FL. |
| Saturday, September 23 |
| » Lost to Tigers (95-59), 4-2 | Wrigley Field (42-33) | 66-88 | Lost 6 |
| » Starters: Jim Bunning vs Ken McBride | Eighth | 38 out |
| Sunday, September 24 |
| » Lost to Tigers (96-59), 7-5 | Wrigley Field (42-34) | 66-89 | Lost 7 |
| » Starters: Paul Foytack vs Dean Chance | Eighth | 38 out |
| Tuesday, September 26 |
| » Lost to Senators (59-97), 3-2 | Wrigley Field (42-35) | 66-90 | Lost 8 |
| » Starters: Bennie Daniels vs Ted Bowsfield | Eighth | 39 out |
| Wednesday, September 27 |
| » Defeated Senators (59-98), 8-6 | Wrigley Field (43-35) | 67-90 | |
| » Starters: Claude Osteen vs Bob Sprout | Eighth | 38 out |
| » Major-league debuts: Bob Sprout (Angels) |
| Thursday, September 28 |
| » Defeated Senators (59-99), 13-4 | Wrigley Field (44-35) | 68-90 | Won 2 |
| » Starters: Dick Donovan vs Eli Grba | Eighth | 37½ out |
| Friday, September 29 |
| » Defeated Indians (77-82), 6-4 | Wrigley Field (45-35) | 69-90 | Won 3 |
| » Starters: Barry Latman vs Dean Chance | Eighth | 37½ out |
| Saturday, September 30 |
| » Defeated Indians (77-83), 11-6 | Wrigley Field (46-35) | 70-90 | Won 4 |
| » Starters: Gary Bell vs Ken McBride | Eighth | 37½ out |
| Sunday, October 1 |
| » Lost to Indians (78-83), 8-5 | Wrigley Field (46-36) | 70-91 | |
| » Starters: Mudcat Grant vs Ryne Duren | Eighth | 38½ out |
| Thursday, October 19 |
| Future Angel Tim Belcher is born in Mount Gilead, OH. |
| Thursday, October 26 |
| Future Angel Gus Polidor is born in Caracas, Venezuela. |
| Monday, December 18 |
| Future Angel Scott Bailes is born in Chillicothe, OH. |
| Friday, December 22 |
| Future Angel Andy Allanson is born in Richmond, VA. |
Game information provided by Retrosheet (www.retrosheet.org) |
