| Tuesday, January 12 |
| Future White Sox Tim Hulett is born in Springfield, IL. |
| Monday, February 29 |
| Future White Sox Bill Long is born in Cincinnati, OH. |
| Thursday, March 3 |
| Future White Sox Chuck Cary is born in Whittier, CA. |
| Monday, March 14 |
| Future White Sox Jerry Willard is born in Oxnard, CA. |
| Friday, March 18 |
| Former White Sox Dixie Howell dies in Hollywood, FL at the age of 41. |
| Tuesday, March 22 |
| Future White Sox Scott Bradley is born in Glen Ridge, NJ. |
| Tuesday, April 12 |
| Future White Sox Bill Lindsey is born in Staten Island, NY. |
| Friday, April 15 |
| Future White Sox Mike Diaz is born in San Francisco, CA. |
| Sunday, April 17 |
| » Major-league debuts: Chris Cannizzaro (Cardinals) |
| Monday, April 18 |
| » Major-league debuts: Don Mincher (Senators) |
| Tuesday, April 19 |
| » Defeated Athletics (0-1), 10-9 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: Bud Daley vs Early Wynn | First | -- |
| Thursday, April 21 |
| » Defeated Athletics (0-2), 6-5 | Comiskey Park I (2-0) | 2-0 | Won 2 |
| » Starters: Ned Garver vs Bob Shaw | First | -- |
| Friday, April 22 |
| » Lost to Tigers (3-0), 6-5 | Tiger Stadium (0-1) | 2-1 | |
| » Starters: Dick Donovan vs Jim Bunning | Third | 1 out |
| Saturday, April 23 |
| » Lost to Tigers (4-0), 6-2 | Tiger Stadium (0-2) | 2-2 | Lost 2 |
| » Starters: Billy Pierce vs Frank Lary | Third | 2 out |
| Sunday, April 24 |
| » Lost to Tigers (5-0), 12-4 | Tiger Stadium (0-3) | 2-3 | Lost 3 |
| » Starters: Early Wynn vs Paul Foytack | Fifth | 3 out |
| Monday, April 25 |
| » Lost to Athletics (3-3), 6-1 | Municipal Stadium (0-1) | 2-4 | Lost 4 |
| » Starters: Herb Score vs Bud Daley | Sixth | 3½ out |
| Tuesday, April 26 |
| » Defeated Athletics (3-4), 8-0 | Municipal Stadium (1-1) | 3-4 | |
| » Starters: Bob Shaw vs Ned Garver | Fifth | 2½ out |
| Wednesday, April 27 |
| Future White Sox Brian Giles is born in Manhattan, KS. |
| Thursday, April 28 |
| » Defeated Indians (2-5), 3-1 | Comiskey Park I (3-0) | 4-4 | Won 2 |
| » Starters: Gary Bell vs Billy Pierce | Third | 1 out |
| Friday, April 29 |
| » Defeated Tigers (5-4), 3-1 | Comiskey Park I (4-0) | 5-4 | Won 3 |
| » Starters: Frank Lary vs Early Wynn | First | -- |
| Sunday, May 1 |
| » Defeated Tigers (5-5), 6-3 | Comiskey Park I (5-0) | 6-4 | Won 4 |
| » Starters: Jim Bunning vs Bob Shaw | First | -- |
| » Defeated Tigers (5-6), 5-2 | Comiskey Park I (6-0) | 7-4 | Won 5 |
| » Starters: Paul Foytack vs Dick Donovan | First | -- |
| Future White Sox Charlie O'Brien is born in Tulsa, OK. |
| Monday, May 2 |
| » Lost to Orioles (8-6), 11-6 | Memorial Stadium (0-1) | 7-5 | |
| » Starters: Herb Score vs Jerry Walker | First | -- |
| Tuesday, May 3 |
| » Defeated Orioles (8-7), 5-3 | Memorial Stadium (1-1) | 8-5 | |
| » Starters: Billy Pierce vs Steve Barber | First | -- |
| Wednesday, May 4 |
| » Lost to Orioles (9-7), 6-4 | Memorial Stadium (1-2) | 8-6 | |
| » Starters: Early Wynn vs Hoyt Wilhelm | Second | ½ out |
| Thursday, May 5 |
| » Defeated Senators (7-8), 5-3 | Griffith Stadium (1-0) | 9-6 | |
| » Starters: Bob Shaw vs Russ Kemmerer | Second | 1 out |
| Friday, May 6 |
| » Defeated Senators (7-9), 3-0 | Griffith Stadium (2-0) | 10-6 | Won 2 |
| » Starters: Herb Score vs Pedro Ramos | Second | 1 out |
| Saturday, May 7 |
| » Defeated Senators (7-10), 6-4 | Griffith Stadium (3-0) | 11-6 | Won 3 |
| » Starters: Dick Donovan vs Jim Kaat | Second | 1 out |
| Sunday, May 8 |
| » Defeated Yankees (10-6), 8-3 | Yankee Stadium (1-0) | 12-6 | Won 4 |
| » Starters: Billy Pierce vs Art Ditmar | First | -- |
| Tuesday, May 10 |
| » Lost to Red Sox (9-7), 9-7 | Fenway Park (0-1) | 12-7 | |
| » Starters: Early Wynn vs Jerry Casale | First | -- |
| Thursday, May 12 |
| » Lost to Red Sox (10-7), 1-0 | Fenway Park (0-2) | 12-8 | Lost 2 |
| » Starters: Bob Shaw vs Tom Brewer | First | -- |
| Friday, May 13 |
| » Defeated Indians (11-9), 4-2 | Cleveland Stadium (1-0) | 13-8 | |
| » Starters: Billy Pierce vs Wynn Hawkins | First | -- |
| Saturday, May 14 |
| » Lost to Indians (12-9), 10-9 | Cleveland Stadium (1-1) | 13-9 | |
| » Starters: Herb Score vs Barry Latman | First | -- |
| Sunday, May 15 |
| » Defeated Indians (12-10), 4-0 | Cleveland Stadium (2-1) | 14-9 | |
| » Starters: Early Wynn vs Jim Perry | First | -- |
| » Lost to Indians (13-10), 6-3 | Cleveland Stadium (2-2) | 14-10 | |
| » Starters: Dick Donovan vs Dick Stigman | First | -- |
| Tuesday, May 17 |
| » Defeated Red Sox (10-11), 11-6 | Comiskey Park I (7-0) | 15-10 | |
| » Starters: Tom Brewer vs Bob Shaw | First | -- |
| Wednesday, May 18 |
| » Defeated Red Sox (10-12), 6-5 | Comiskey Park I (8-0) | 16-10 | Won 2 |
| » Starters: Frank Sullivan vs Billy Pierce | First | -- |
| Friday, May 20 |
| » Defeated Yankees (13-11), 5-3 | Comiskey Park I (9-0) | 17-10 | Won 3 |
| » Starters: Whitey Ford vs Early Wynn | First | -- |
| Saturday, May 21 |
| » Defeated Yankees (13-12), 9-8 | Comiskey Park I (10-0) | 18-10 | Won 4 |
| » Starters: Art Ditmar vs Dick Donovan | First | -- |
| Sunday, May 22 |
| » Lost to Senators (11-16), 7-5 | Comiskey Park I (10-1) | 18-11 | |
| » Starters: Camilo Pascual vs Bob Shaw | First | -- |
| » Lost to Senators (12-16), 3-2 | Comiskey Park I (10-2) | 18-12 | Lost 2 |
| » Starters: Pedro Ramos vs Billy Pierce | First | -- |
| Tuesday, May 24 |
| » Lost to Orioles (19-13), 6-1 | Comiskey Park I (10-3) | 18-13 | Lost 3 |
| » Starters: Steve Barber vs Herb Score | Third | ½ out |
| » Major-league debuts: Dave Nicholson (Orioles) |
| Wednesday, May 25 |
| » Lost to Orioles (20-13), 3-2 | Comiskey Park I (10-4) | 18-14 | Lost 4 |
| » Starters: Chuck Estrada vs Early Wynn | Third | 1½ out |
| Thursday, May 26 |
| » Defeated Athletics (13-21), 3-1 | Municipal Stadium (2-1) | 19-14 | |
| » Starters: Bob Shaw vs Dick Hall | Third | 1½ out |
| Friday, May 27 |
| » Defeated Athletics (13-22), 7-4 | Municipal Stadium (3-1) | 20-14 | Won 2 |
| » Starters: Billy Pierce vs Ray Herbert | Third | ½ out |
| Saturday, May 28 |
| » Lost to Athletics (14-22), 4-3 | Municipal Stadium (3-2) | 20-15 | |
| » Starters: Dick Donovan vs Bud Daley | Third | 1 out |
| Sunday, May 29 |
| » Lost to Athletics (15-22), 4-2 | Municipal Stadium (3-3) | 20-16 | Lost 2 |
| » Starters: Herb Score vs Ken Johnson | Third | 2½ out |
| Monday, May 30 |
| » Lost to Indians (20-14), 4-1 | Comiskey Park I (10-5) | 20-17 | Lost 3 |
| » Starters: Jim Perry vs Early Wynn | Fourth | 3½ out |
| » Lost to Indians (21-14), 9-4 | Comiskey Park I (10-6) | 20-18 | Lost 4 |
| » Starters: Barry Latman vs Bob Shaw | Fourth | 3½ out |
| Tuesday, May 31 |
| » Defeated Indians (21-15), 6-4 | Comiskey Park I (11-6) | 21-18 | |
| » Starters: Gary Bell vs Billy Pierce | Third | 3½ out |
| Future White Sox Jeff Schaefer is born in Patchogue, NY. |
| Wednesday, June 1 |
| » Defeated Tigers (17-19), 6-0 | Tiger Stadium (1-3) | 22-18 | Won 2 |
| » Starters: Frank Baumann vs Jim Bunning | Third | 3½ out |
| Thursday, June 2 |
| » Lost to Tigers (18-19), 4-3 | Tiger Stadium (1-4) | 22-19 | |
| » Starters: Dick Donovan vs Don Mossi | Third | 4½ out |
| Friday, June 3 |
| » Lost to Athletics (19-23), 7-2 | Comiskey Park I (11-7) | 22-20 | Lost 2 |
| » Starters: Bud Daley vs Early Wynn | Third | 4½ out |
| Future White Sox Steve Lyons is born in Tacoma, WA. |
| Saturday, June 4 |
| » Defeated Athletics (19-24), 4-2 | Comiskey Park I (12-7) | 23-20 | |
| » Starters: Ken Johnson vs Bob Shaw | Third | 3½ out |
| Sunday, June 5 |
| » Defeated Athletics (19-25), 2-0 | Comiskey Park I (13-7) | 24-20 | Won 2 |
| » Starters: Dick Hall vs Russ Kemmerer | Third | 3 out |
| » Defeated Athletics (19-26), 2-0 | Comiskey Park I (14-7) | 25-20 | Won 3 |
| » Starters: Ned Garver vs Frank Baumann | Third | 3 out |
| Monday, June 6 |
| » Defeated Yankees (22-21), 3-2 | Yankee Stadium (2-0) | 26-20 | Won 4 |
| » Starters: Billy Pierce vs Whitey Ford | Third | 3 out |
| Tuesday, June 7 |
| » Lost to Yankees (23-21), 5-2 | Yankee Stadium (2-1) | 26-21 | |
| » Starters: Early Wynn vs Jim Coates | Third | 3 out |
| Wednesday, June 8 |
| » Lost to Yankees (24-21), 6-0 | Yankee Stadium (2-2) | 26-22 | Lost 2 |
| » Starters: Bob Shaw vs Bob Turley | Third | 3 out |
| Thursday, June 9 |
| » Lost to Yankees (25-21), 5-2 | Yankee Stadium (2-3) | 26-23 | Lost 3 |
| » Starters: Frank Baumann vs Ralph Terry | Fifth | 4 out |
| Friday, June 10 |
| » Defeated Red Sox (15-31), 13-3 | Fenway Park (1-2) | 27-23 | |
| » Starters: Russ Kemmerer vs Tom Brewer | Fifth | 3 out |
| Saturday, June 11 |
| » Lost to Red Sox (16-31), 5-4 | Fenway Park (1-3) | 27-24 | |
| » Starters: Early Wynn vs Ike Delock | Fourth | 3 out |
| » Defeated Red Sox (16-32), 8-4 | Fenway Park (2-3) | 28-24 | |
| » Starters: Billy Pierce vs Jerry Casale | Fourth | 3 out |
| Sunday, June 12 |
| » Lost to Red Sox (17-32), 4-1 | Fenway Park (2-4) | 28-25 | |
| » Starters: Bob Shaw vs Frank Sullivan | Fifth | 3 out |
| Wednesday, June 15 |
| » Defeated Senators (22-29), 6-4 | Comiskey Park I (15-7) | 29-25 | |
| » Starters: Pedro Ramos vs Russ Kemmerer | Third | 2 out |
| Thursday, June 16 |
| » Defeated Senators (22-30), 10-4 | Comiskey Park I (16-7) | 30-25 | Won 2 |
| » Starters: Chuck Stobbs vs Frank Baumann | Third | 2½ out |
| Friday, June 17 |
| » Lost to Yankees (30-22), 4-2 | Comiskey Park I (16-8) | 30-26 | |
| » Starters: Art Ditmar vs Billy Pierce | Fourth | 3½ out |
| Saturday, June 18 |
| » Lost to Yankees (31-22), 12-5 | Comiskey Park I (16-9) | 30-27 | Lost 2 |
| » Starters: Bob Turley vs Early Wynn | Fifth | 3 out |
| Sunday, June 19 |
| » Lost to Yankees (32-22), 7-5 | Comiskey Park I (16-10) | 30-28 | Lost 3 |
| » Starters: Jim Coates vs Bob Shaw | Fifth | 5 out |
| » Lost to Yankees (33-22), 5-3 | Comiskey Park I (16-11) | 30-29 | Lost 4 |
| » Starters: Gabe Gabler vs Russ Kemmerer | Fifth | 5 out |
| Tuesday, June 21 |
| » Defeated Orioles (37-26), 4-3 | Comiskey Park I (17-11) | 31-29 | |
| » Starters: Steve Barber vs Billy Pierce | Fourth | 5 out |
| Wednesday, June 22 |
| » Defeated Orioles (37-27), 3-1 | Comiskey Park I (18-11) | 32-29 | Won 2 |
| » Starters: Jack Fisher vs Early Wynn | Fourth | 5 out |
| Thursday, June 23 |
| » Lost to Orioles (38-27), 5-3 | Comiskey Park I (18-12) | 32-30 | |
| » Starters: Jerry Walker vs Frank Baumann | Fourth | 5 out |
| Friday, June 24 |
| » Defeated Red Sox (22-39), 2-1 | Comiskey Park I (19-12) | 33-30 | |
| » Starters: Bill Monbouquette vs Bob Shaw | Fourth | 5 out |
| Saturday, June 25 |
| » Defeated Red Sox (22-40), 7-6 | Comiskey Park I (20-12) | 34-30 | Won 2 |
| » Starters: Tom Brewer vs Russ Kemmerer | Fourth | 4 out |
| Sunday, June 26 |
| » Defeated Red Sox (22-41), 4-3 | Comiskey Park I (21-12) | 35-30 | Won 3 |
| » Starters: Frank Sullivan vs Billy Pierce | Fourth | 4 out |
| » Defeated Red Sox (22-42), 21-7 | Comiskey Park I (22-12) | 36-30 | Won 4 |
| » Starters: Tom Borland vs Early Wynn | Fourth | 4 out |
| Tuesday, June 28 |
| » Lost to Senators (30-34), 2-1 | Griffith Stadium (3-1) | 36-31 | |
| » Starters: Frank Baumann vs Hal Woodeshick | Fourth | 4 out |
| Thursday, June 30 |
| » Defeated Senators (30-35), 4-2 | Griffith Stadium (4-1) | 37-31 | |
| » Starters: Bob Shaw vs Pedro Ramos | Fourth | 4½ out |
| Friday, July 1 |
| » Lost to Orioles (43-30), 4-0 | Memorial Stadium (1-3) | 37-32 | |
| » Starters: Billy Pierce vs Milt Pappas | Fourth | 5 out |
| Saturday, July 2 |
| » Defeated Orioles (43-31), 8-7 | Memorial Stadium (2-3) | 38-32 | |
| » Starters: Early Wynn vs Chuck Estrada | Fourth | 5 out |
| Sunday, July 3 |
| » Defeated Orioles (43-32), 2-1 | Memorial Stadium (3-3) | 39-32 | Won 2 |
| » Starters: Herb Score vs Jack Fisher | Fourth | 5½ out |
| Monday, July 4 |
| » Lost to Tigers (33-37), 3-0 | Tiger Stadium (1-5) | 39-33 | |
| » Starters: Frank Baumann vs Jim Bunning | Fourth | 6 out |
| » Lost to Tigers (34-37), 3-2 | Tiger Stadium (1-6) | 39-34 | Lost 2 |
| » Starters: Bob Shaw vs Bob Bruce | Fourth | 6 out |
| Wednesday, July 6 |
| » Defeated Indians (42-29), 7-5 | Cleveland Stadium (3-2) | 40-34 | |
| » Starters: Early Wynn vs Dick Stigman | Fourth | 5½ out |
| Thursday, July 7 |
| » Defeated Indians (42-30), 9-3 | Cleveland Stadium (4-2) | 41-34 | Won 2 |
| » Starters: Billy Pierce vs Jim Perry | Fourth | 5½ out |
| Friday, July 8 |
| » Defeated Indians (42-31), 4-1 | Comiskey Park I (23-12) | 42-34 | Won 3 |
| » Starters: Gary Bell vs Frank Baumann | Fourth | 4½ out |
| Saturday, July 9 |
| » Defeated Indians (42-32), 8-4 | Comiskey Park I (24-12) | 43-34 | Won 4 |
| » Starters: Ted Bowsfield vs Herb Score | Third | 3½ out |
| Sunday, July 10 |
| » Lost to Indians (43-32), 6-2 | Comiskey Park I (24-13) | 43-35 | |
| » Starters: Jim Perry vs Early Wynn | Third | 3 out |
| » Defeated Indians (43-33), 6-4 | Comiskey Park I (25-13) | 44-35 | |
| » Starters: Dick Stigman vs Bob Shaw | Third | 3 out |
| Friday, July 15 |
| » Lost to Orioles (46-38), 5-2 | Comiskey Park I (25-14) | 44-36 | |
| » Starters: Milt Pappas vs Billy Pierce | Third | 3 out |
| Saturday, July 16 |
| » Lost to Orioles (47-38), 4-3 | Comiskey Park I (25-15) | 44-37 | Lost 2 |
| » Starters: Jerry Walker vs Frank Baumann | Fourth | 4 out |
| Sunday, July 17 |
| » Defeated Orioles (47-39), 2-1 | Comiskey Park I (26-15) | 45-37 | |
| » Starters: Steve Barber vs Bob Shaw | Third | 2 out |
| » Defeated Orioles (47-40), 14-2 | Comiskey Park I (27-15) | 46-37 | Won 2 |
| » Starters: Jack Fisher vs Early Wynn | Third | 2 out |
| Monday, July 18 |
| » Defeated Red Sox (33-49), 9-1 | Comiskey Park I (28-15) | 47-37 | Won 3 |
| » Starters: Billy Muffett vs Herb Score | Second | 2 out |
| Tuesday, July 19 |
| » Defeated Red Sox (33-50), 6-0 | Comiskey Park I (29-15) | 48-37 | Won 4 |
| » Starters: Frank Sullivan vs Billy Pierce | Second | 2 out |
| Wednesday, July 20 |
| » Defeated Red Sox (33-51), 7-1 | Comiskey Park I (30-15) | 49-37 | Won 5 |
| » Starters: Bill Monbouquette vs Russ Kemmerer | Second | 2 out |
| Friday, July 22 |
| » Defeated Yankees (48-35), 11-5 | Yankee Stadium (3-3) | 50-37 | Won 6 |
| » Starters: Early Wynn vs Bob Turley | Second | 2 out |
| Saturday, July 23 |
| » Defeated Yankees (48-36), 5-3 | Yankee Stadium (4-3) | 51-37 | Won 7 |
| » Starters: Bob Shaw vs Whitey Ford | First | -- |
| Sunday, July 24 |
| » Defeated Yankees (48-37), 6-3 | Yankee Stadium (5-3) | 52-37 | Won 8 |
| » Starters: Billy Pierce vs Jim Coates | First | -- |
| » Lost to Yankees (49-37), 8-2 | Yankee Stadium (5-4) | 52-38 | |
| » Starters: Herb Score vs Eli Grba | First | -- |
| Tuesday, July 26 |
| » Defeated Red Sox (36-53), 16-3 | Fenway Park (3-4) | 53-38 | |
| » Starters: Early Wynn vs Jerry Casale | First | -- |
| Wednesday, July 27 |
| » Defeated Red Sox (36-54), 10-4 | Fenway Park (4-4) | 54-38 | Won 2 |
| » Starters: Bob Shaw vs Ike Delock | First | -- |
| Thursday, July 28 |
| » Lost to Red Sox (37-54), 4-2 | Fenway Park (4-5) | 54-39 | |
| » Starters: Billy Pierce vs Tom Brewer | Second | 2 out |
| Friday, July 29 |
| » Lost to Senators (46-45), 7-5 | Griffith Stadium (4-2) | 54-40 | Lost 2 |
| » Starters: Dick Donovan vs Camilo Pascual | Second | 2 out |
| Saturday, July 30 |
| » Defeated Senators (46-46), 3-2 | Griffith Stadium (5-2) | 55-40 | |
| » Starters: Frank Baumann vs Don Lee | First | -- |
| Sunday, July 31 |
| » Defeated Senators (46-47), 5-2 | Griffith Stadium (6-2) | 56-40 | Won 2 |
| » Starters: Early Wynn vs Pedro Ramos | First | -- |
| » Defeated Senators (46-48), 9-5 | Griffith Stadium (7-2) | 57-40 | Won 3 |
| » Starters: Bob Shaw vs Jack Kralick | First | -- |
| Former White Sox Joe Klinger dies in Little Rock, AR at the age of 58. |
| Monday, August 1 |
| » Lost to Orioles (55-45), 2-1 | Memorial Stadium (3-4) | 57-41 | |
| » Starters: Herb Score vs Milt Pappas | First | -- |
| Tuesday, August 2 |
| » Lost to Orioles (56-45), 6-2 | Memorial Stadium (3-5) | 57-42 | Lost 2 |
| » Starters: Billy Pierce vs Steve Barber | Second | 2 out |
| Wednesday, August 3 |
| » Lost to Orioles (57-45), 6-5 | Memorial Stadium (3-6) | 57-43 | Lost 3 |
| » Starters: Frank Baumann vs Hoyt Wilhelm | Second | 2 out |
| Thursday, August 4 |
| » Lost to Senators (48-50), 2-1 | Comiskey Park I (30-16) | 57-44 | Lost 4 |
| » Starters: Don Lee vs Early Wynn | Second | 2½ out |
| Friday, August 5 |
| » Lost to Senators (49-50), 6-1 | Comiskey Park I (30-17) | 57-45 | Lost 5 |
| » Starters: Pedro Ramos vs Bob Shaw | Second | 2½ out |
| Saturday, August 6 |
| » Defeated Senators (49-51), 9-2 | Comiskey Park I (31-17) | 58-45 | |
| » Starters: Chuck Stobbs vs Herb Score | Second | 2½ out |
| Sunday, August 7 |
| » Defeated Senators (49-52), 9-7 | Comiskey Park I (32-17) | 59-45 | Won 2 |
| » Starters: Camilo Pascual vs Frank Baumann | Second | 2½ out |
| » Defeated Senators (49-53), 3-2 | Comiskey Park I (33-17) | 60-45 | Won 3 |
| » Starters: Tex Clevenger vs Bob Shaw | Second | 2½ out |
| Monday, August 8 |
| » Defeated Yankees (59-42), 9-1 | Comiskey Park I (34-17) | 61-45 | Won 4 |
| » Starters: Whitey Ford vs Billy Pierce | Second | 2½ out |
| Tuesday, August 9 |
| » Lost to Yankees (60-42), 7-4 | Comiskey Park I (34-18) | 61-46 | |
| » Starters: Bob Turley vs Early Wynn | Second | 2½ out |
| Wednesday, August 10 |
| » Lost to Yankees (61-42), 6-0 | Comiskey Park I (34-19) | 61-47 | Lost 2 |
| » Starters: Art Ditmar vs Herb Score | Third | 2½ out |
| » Major-league debuts: Floyd Robinson (White Sox) |
| Friday, August 12 |
| » Defeated Athletics (41-65), 6-4 | Comiskey Park I (35-19) | 62-47 | |
| » Starters: Bud Daley vs Bob Shaw | Third | 2½ out |
| Saturday, August 13 |
| » Defeated Athletics (41-66), 8-3 | Comiskey Park I (36-19) | 63-47 | Won 2 |
| » Starters: John Tsitouris vs Frank Baumann | Third | 2½ out |
| Sunday, August 14 |
| » Defeated Athletics (41-67), 9-3 | Comiskey Park I (37-19) | 64-47 | Won 3 |
| » Starters: Johnny Kucks vs Billy Pierce | First | -- |
| » Defeated Athletics (41-68), 7-2 | Comiskey Park I (38-19) | 65-47 | Won 4 |
| » Starters: Don Larsen vs Early Wynn | First | -- |
| Monday, August 15 |
| » Lost to Tigers (50-59), 4-1 | Comiskey Park I (38-20) | 65-48 | |
| » Starters: Bob Bruce vs Herb Score | Second | 2½ out |
| Tuesday, August 16 |
| » Defeated Tigers (50-60), 3-2 | Comiskey Park I (39-20) | 66-48 | |
| » Starters: Jim Bunning vs Frank Baumann | Second | 2½ out |
| Wednesday, August 17 |
| » Lost to Indians (55-54), 3-2 | Cleveland Stadium (4-3) | 66-49 | |
| » Starters: Bob Shaw vs Jim Perry | Second | 2½ out |
| Thursday, August 18 |
| » Lost to Indians (56-54), 8-6 | Cleveland Stadium (4-4) | 66-50 | Lost 2 |
| » Starters: Billy Pierce vs Mudcat Grant | Second | 2½ out |
| Friday, August 19 |
| » Defeated Athletics (41-72), 10-0 | Municipal Stadium (4-3) | 67-50 | |
| » Starters: Early Wynn vs Johnny Kucks | Second | 2½ out |
| Saturday, August 20 |
| » Defeated Athletics (41-73), 3-0 | Municipal Stadium (5-3) | 68-50 | Won 2 |
| » Starters: Herb Score vs Don Larsen | Second | 2½ out |
| Sunday, August 21 |
| » Lost to Athletics (42-73), 8-1 | Municipal Stadium (5-4) | 68-51 | |
| » Starters: Bob Shaw vs Ray Herbert | Second | 2½ out |
| Tuesday, August 23 |
| » Defeated Yankees (67-48), 5-1 | Yankee Stadium (6-4) | 69-51 | |
| » Starters: Early Wynn vs Eli Grba | Second | 2½ out |
| Wednesday, August 24 |
| » Lost to Yankees (68-48), 3-2 | Yankee Stadium (6-5) | 69-52 | |
| » Starters: Herb Score vs Art Ditmar | Second | 2½ out |
| Friday, August 26 |
| » Defeated Red Sox (50-69), 9-2 | Fenway Park (5-5) | 70-52 | |
| » Starters: Frank Baumann vs Earl Wilson | Third | 2 out |
| Saturday, August 27 |
| » Defeated Red Sox (50-70), 9-6 | Fenway Park (6-5) | 71-52 | Won 2 |
| » Starters: Bob Shaw vs Ike Delock | Second | 2½ out |
| Sunday, August 28 |
| » Lost to Orioles (73-53), 3-1 | Memorial Stadium (3-7) | 71-53 | |
| » Starters: Early Wynn vs Milt Pappas | Third | 3 out |
| Monday, August 29 |
| » Lost to Orioles (74-53), 4-0 | Memorial Stadium (3-8) | 71-54 | Lost 2 |
| » Starters: Herb Score vs Jack Fisher | Third | 3½ out |
| Tuesday, August 30 |
| » Defeated Senators (63-63), 11-10 | Griffith Stadium (8-2) | 72-54 | |
| » Starters: Frank Baumann vs Pedro Ramos | Third | 3½ out |
| Wednesday, August 31 |
| » Lost to Senators (64-63), 2-1 | Griffith Stadium (8-3) | 72-55 | |
| » Starters: Bob Shaw vs Jack Kralick | Third | 4 out |
| Friday, September 2 |
| » Defeated Tigers (59-68), 7-5 | Comiskey Park I (40-20) | 73-55 | |
| » Starters: Phil Regan vs Herb Score | Third | 3 out |
| Saturday, September 3 |
| » Defeated Tigers (59-69), 4-1 | Comiskey Park I (41-20) | 74-55 | Won 2 |
| » Starters: Frank Lary vs Early Wynn | Third | 3 out |
| Sunday, September 4 |
| » Lost to Tigers (60-69), 6-4 | Comiskey Park I (41-21) | 74-56 | |
| » Starters: Jim Bunning vs Frank Baumann | Third | 3½ out |
| » Defeated Tigers (60-70), 5-4 | Comiskey Park I (42-21) | 75-56 | |
| » Starters: Bob Bruce vs Billy Pierce | Third | 3½ out |
| Monday, September 5 |
| » Lost to Athletics (46-86), 8-7 | Municipal Stadium (5-5) | 75-57 | |
| » Starters: Bob Shaw vs Ray Herbert | Third | 4 out |
| Tuesday, September 6 |
| » Lost to Athletics (47-86), 3-2 | Municipal Stadium (5-6) | 75-58 | Lost 2 |
| » Starters: Herb Score vs Ned Garver | Third | 4½ out |
| Wednesday, September 7 |
| » Lost to Yankees (78-54), 6-4 | Comiskey Park I (42-22) | 75-59 | Lost 3 |
| » Starters: Whitey Ford vs Early Wynn | Third | 4½ out |
| Thursday, September 8 |
| » Defeated Yankees (78-55), 5-4 | Comiskey Park I (43-22) | 76-59 | |
| » Starters: Art Ditmar vs Billy Pierce | Third | 4½ out |
| Friday, September 9 |
| » Defeated Orioles (81-56), 5-2 | Comiskey Park I (44-22) | 77-59 | Won 2 |
| » Starters: Chuck Estrada vs Bob Shaw | Third | 3½ out |
| Saturday, September 10 |
| » Defeated Orioles (81-57), 3-2 | Comiskey Park I (45-22) | 78-59 | Won 3 |
| » Starters: Hal Brown vs Herb Score | Third | 3 out |
| Sunday, September 11 |
| » Defeated Red Sox (61-77), 5-3 | Comiskey Park I (46-22) | 79-59 | Won 4 |
| » Starters: Bill Monbouquette vs Billy Pierce | Third | 3 out |
| » Defeated Red Sox (61-78), 1-0 | Comiskey Park I (47-22) | 80-59 | Won 5 |
| » Starters: Billy Muffett vs Early Wynn | Third | 3 out |
| Tuesday, September 13 |
| » Defeated Senators (70-70), 6-5 | Comiskey Park I (48-22) | 81-59 | Won 6 |
| » Starters: Pedro Ramos vs Bob Shaw | Third | 2 out |
| Wednesday, September 14 |
| » Lost to Senators (71-70), 6-1 | Comiskey Park I (48-23) | 81-60 | |
| » Starters: Jack Kralick vs Herb Score | Third | 2 out |
| Friday, September 16 |
| » Lost to Tigers (65-77), 4-3 | Tiger Stadium (1-7) | 81-61 | Lost 2 |
| » Starters: Early Wynn vs Frank Lary | Third | 3 out |
| Saturday, September 17 |
| » Defeated Tigers (65-78), 8-4 | Tiger Stadium (2-7) | 82-61 | |
| » Starters: Billy Pierce vs Bill Fischer | Third | 3 out |
| » Major-league debuts: Dick McAuliffe (Tigers) |
| Sunday, September 18 |
| » Defeated Tigers (65-79), 8-4 | Tiger Stadium (3-7) | 83-61 | Won 2 |
| » Starters: Frank Baumann vs Jim Bunning | Second | 4 out |
| » Lost to Tigers (66-79), 7-6 | Tiger Stadium (3-8) | 83-62 | |
| » Starters: Russ Kemmerer vs Bob Bruce | Second | 4 out |
| » Major-league debuts: Stan Johnson (White Sox) |
| Tuesday, September 20 |
| » Major-league debuts: Deron Johnson (Yankees) |
| Future White Sox Dave Gallagher is born in Trenton, NJ. |
| Wednesday, September 21 |
| » Defeated Athletics (52-93), 7-2 | Comiskey Park I (49-23) | 84-62 | |
| » Starters: Bud Daley vs Herb Score | Second | 4½ out |
| » Major-league debuts: Leo Posada (Athletics) |
| Thursday, September 22 |
| » Major-league debuts: Dick Bertell (Cubs) |
| Friday, September 23 |
| » Defeated Indians (72-74), 7-0 | Cleveland Stadium (5-4) | 85-62 | Won 2 |
| » Starters: Early Wynn vs Barry Latman | Second | 4½ out |
| Saturday, September 24 |
| » Lost to Indians (73-74), 6-5 | Cleveland Stadium (5-5) | 85-63 | |
| » Starters: Billy Pierce vs Jim Perry | Second | 5½ out |
| Sunday, September 25 |
| » Lost to Indians (74-74), 4-0 | Cleveland Stadium (5-6) | 85-64 | Lost 2 |
| » Starters: Bob Shaw vs Bobby Locke | Third | 6½ out |
| Monday, September 26 |
| » Defeated Tigers (68-82), 6-3 | Comiskey Park I (50-23) | 86-64 | |
| » Starters: Bill Fischer vs Frank Baumann | Second | 6½ out |
| Tuesday, September 27 |
| » Lost to Tigers (69-82), 2-0 | Comiskey Park I (50-24) | 86-65 | |
| » Starters: Jim Bunning vs Early Wynn | Third | 7½ out |
| Friday, September 30 |
| » Defeated Indians (74-78), 5-4 | Comiskey Park I (51-24) | 87-65 | |
| » Starters: Bobby Locke vs Billy Pierce | Second | 8 out |
| Saturday, October 1 |
| » Lost to Indians (75-78), 9-8 | Comiskey Park I (51-25) | 87-66 | |
| » Starters: Dick Stigman vs Frank Baumann | Third | 9 out |
| Sunday, October 2 |
| » Lost to Indians (76-78), 4-0 | Comiskey Park I (51-26) | 87-67 | Lost 2 |
| » Starters: Jim Perry vs Early Wynn | Third | 10 out |
| Wednesday, November 2 |
| Former White Sox Everett Scott dies in Fort Wayne, IN at the age of 68. |
