| Monday, January 4 |
| Future Tiger Paul Gibson is born in Southampton, NY. |
| Tuesday, January 12 |
| Future Tiger Mike Trujillo is born in Denver, CO. |
| Thursday, March 3 |
| Future Tiger Chuck Cary is born in Whittier, CA. |
| Tuesday, March 22 |
| Future Tiger Matt Sinatro is born in Hartford, CT. |
| Sunday, April 17 |
| » Major-league debuts: Chris Cannizzaro (Cardinals) |
| Monday, April 18 |
| » Major-league debuts: Don Mincher (Senators) |
| Tuesday, April 19 |
| » Defeated Indians (0-1), 4-2 | Cleveland Stadium (1-0) | 1-0 | |
| » Starters: Frank Lary vs Gary Bell | First | -- |
| » Major-league debuts: Walt Bond (Indians) |
| Wednesday, April 20 |
| » Defeated Indians (0-2), 6-4 | Cleveland Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Don Mossi vs Jim Perry | First | -- |
| Friday, April 22 |
| » Defeated White Sox (2-1), 6-5 | Tiger Stadium (1-0) | 3-0 | Won 3 |
| » Starters: Dick Donovan vs Jim Bunning | First | -- |
| Saturday, April 23 |
| » Defeated White Sox (2-2), 6-2 | Tiger Stadium (2-0) | 4-0 | Won 4 |
| » Starters: Billy Pierce vs Frank Lary | First | -- |
| Sunday, April 24 |
| » Defeated White Sox (2-3), 12-4 | Tiger Stadium (3-0) | 5-0 | Won 5 |
| » Starters: Early Wynn vs Paul Foytack | First | -- |
| Tuesday, April 26 |
| » Lost to Indians (2-4), 2-1 | Tiger Stadium (3-1) | 5-1 | |
| » Starters: Wynn Hawkins vs Jim Bunning | First | -- |
| Wednesday, April 27 |
| » Lost to Athletics (4-4), 3-1 | Municipal Stadium (0-1) | 5-2 | Lost 2 |
| » Starters: Hank Aguirre vs Ray Herbert | First | -- |
| Thursday, April 28 |
| » Lost to Athletics (5-4), 2-1 | Municipal Stadium (0-2) | 5-3 | Lost 3 |
| » Starters: Don Mossi vs Dick Hall | First | -- |
| Future Tiger John Cerutti is born in Albany, NY. |
| Friday, April 29 |
| » Lost to White Sox (5-4), 3-1 | Comiskey Park I (0-1) | 5-4 | Lost 4 |
| » Starters: Frank Lary vs Early Wynn | First | -- |
| Saturday, April 30 |
| Former Tiger Herman Pillette dies in Sacramento, CA at the age of 65. |
| Sunday, May 1 |
| » Lost to White Sox (6-4), 6-3 | Comiskey Park I (0-2) | 5-5 | Lost 5 |
| » Starters: Jim Bunning vs Bob Shaw | Fourth | 2 out |
| » Lost to White Sox (7-4), 5-2 | Comiskey Park I (0-3) | 5-6 | Lost 6 |
| » Starters: Paul Foytack vs Dick Donovan | Fourth | 2 out |
| Tuesday, May 3 |
| » Lost to Yankees (7-5), 10-3 | Yankee Stadium (0-1) | 5-7 | Lost 7 |
| » Starters: Don Mossi vs Whitey Ford | Seventh | 2½ out |
| Wednesday, May 4 |
| » Lost to Yankees (8-5), 4-2 | Yankee Stadium (0-2) | 5-8 | Lost 8 |
| » Starters: Frank Lary vs Bill Short | Seventh | 3 out |
| Friday, May 6 |
| » Lost to Red Sox (7-7), 3-2 | Fenway Park (0-1) | 5-9 | Lost 9 |
| » Starters: Jim Bunning vs Frank Sullivan | Eighth | 4 out |
| Saturday, May 7 |
| » Lost to Red Sox (8-7), 5-0 | Fenway Park (0-2) | 5-10 | Lost 10 |
| » Starters: Paul Foytack vs Bill Monbouquette | Eighth | 5 out |
| Tuesday, May 10 |
| » Defeated Senators (8-11), 1-0 | Griffith Stadium (1-0) | 6-10 | |
| » Starters: Don Mossi vs Tex Clevenger | Seventh | 4½ out |
| Wednesday, May 11 |
| » Defeated Senators (8-12), 1-0 | Griffith Stadium (2-0) | 7-10 | Won 2 |
| » Starters: Frank Lary vs Pedro Ramos | Sixth | 4 out |
| Friday, May 13 |
| » Defeated Athletics (7-14), 4-3 | Tiger Stadium (4-1) | 8-10 | Won 3 |
| » Starters: Ray Herbert vs Jim Bunning | Sixth | 3½ out |
| Saturday, May 14 |
| » Defeated Athletics (7-15), 7-6 | Tiger Stadium (5-1) | 9-10 | Won 4 |
| » Starters: Johnny Kucks vs Paul Foytack | Sixth | 2½ out |
| Sunday, May 15 |
| » Lost to Athletics (8-15), 5-0 | Tiger Stadium (5-2) | 9-11 | |
| » Starters: Bud Daley vs Don Mossi | Fifth | 3½ out |
| » Lost to Athletics (9-15), 5-4 | Tiger Stadium (5-3) | 9-12 | Lost 2 |
| » Starters: Dick Hall vs Pete Burnside | Fifth | 3½ out |
| Tuesday, May 17 |
| » Defeated Senators (9-15), 3-1 | Tiger Stadium (6-3) | 10-12 | |
| » Starters: Pedro Ramos vs Frank Lary | Sixth | 3½ out |
| Wednesday, May 18 |
| » Lost to Senators (10-15), 3-0 | Tiger Stadium (6-4) | 10-13 | |
| » Starters: Camilo Pascual vs Jim Bunning | Sixth | 4½ out |
| Friday, May 20 |
| » Defeated Orioles (16-13), 4-3 | Tiger Stadium (7-4) | 11-13 | |
| » Starters: Jerry Walker vs Don Mossi | Fifth | 4½ out |
| Saturday, May 21 |
| » Lost to Orioles (17-13), 7-4 | Tiger Stadium (7-5) | 11-14 | |
| » Starters: Arnie Portocarrero vs Frank Lary | Fifth | 5½ out |
| Sunday, May 22 |
| » Defeated Red Sox (10-15), 6-2 | Tiger Stadium (8-5) | 12-14 | |
| » Starters: Tom Brewer vs Jim Bunning | Fifth | 3½ out |
| » Defeated Red Sox (10-16), 5-2 | Tiger Stadium (9-5) | 13-14 | Won 2 |
| » Starters: Frank Sullivan vs Hank Aguirre | Fifth | 3½ out |
| Tuesday, May 24 |
| » Defeated Yankees (15-13), 4-0 | Tiger Stadium (10-5) | 14-14 | Won 3 |
| » Starters: Bill Short vs Don Mossi | Fifth | 3 out |
| Wednesday, May 25 |
| » Defeated Yankees (15-14), 9-3 | Tiger Stadium (11-5) | 15-14 | Won 4 |
| » Starters: Ralph Terry vs Frank Lary | Fourth | 3 out |
| Saturday, May 28 |
| » Defeated Indians (18-13), 4-3 | Tiger Stadium (12-5) | 16-14 | Won 5 |
| » Starters: Gary Bell vs Jim Bunning | Fourth | 2½ out |
| Sunday, May 29 |
| » Defeated Indians (18-14), 6-5 | Tiger Stadium (13-5) | 17-14 | Won 6 |
| » Starters: Wynn Hawkins vs Don Mossi | Fifth | 3½ out |
| » Lost to Indians (19-14), 6-4 | Tiger Stadium (13-6) | 17-15 | |
| » Starters: Mudcat Grant vs Frank Lary | Fifth | 3½ out |
| Monday, May 30 |
| » Lost to Athletics (16-22), 7-6 | Municipal Stadium (0-3) | 17-16 | Lost 2 |
| » Starters: Hank Aguirre vs Johnny Kucks | Fifth | 4½ out |
| » Lost to Athletics (17-22), 8-2 | Municipal Stadium (0-4) | 17-17 | Lost 3 |
| » Starters: Paul Foytack vs Don Larsen | Fifth | 4½ out |
| Tuesday, May 31 |
| » Lost to Athletics (18-22), 2-1 | Municipal Stadium (0-5) | 17-18 | Lost 4 |
| » Starters: Pete Burnside vs Dick Hall | Fifth | 5½ out |
| Wednesday, June 1 |
| » Lost to White Sox (22-18), 6-0 | Tiger Stadium (13-7) | 17-19 | Lost 5 |
| » Starters: Frank Baumann vs Jim Bunning | Fifth | 6½ out |
| Thursday, June 2 |
| » Defeated White Sox (22-19), 4-3 | Tiger Stadium (14-7) | 18-19 | |
| » Starters: Dick Donovan vs Don Mossi | Fifth | 6½ out |
| Friday, June 3 |
| » Lost to Indians (23-15), 6-2 | Cleveland Stadium (2-1) | 18-20 | |
| » Starters: Frank Lary vs Jim Perry | Fifth | 6½ out |
| Saturday, June 4 |
| » Defeated Indians (23-16), 7-4 | Cleveland Stadium (3-1) | 19-20 | |
| » Starters: Paul Foytack vs Barry Latman | Fifth | 5½ out |
| Sunday, June 5 |
| » Defeated Indians (23-17), 7-2 | Cleveland Stadium (4-1) | 20-20 | Won 2 |
| » Starters: Jim Bunning vs Gary Bell | Fifth | 6 out |
| » Lost to Indians (24-17), 9-0 | Cleveland Stadium (4-2) | 20-21 | |
| » Starters: Pete Burnside vs Bobby Locke | Fifth | 6 out |
| Tuesday, June 7 |
| » Defeated Orioles (29-18), 5-2 | Memorial Stadium (1-0) | 21-21 | |
| » Starters: Don Mossi vs Hoyt Wilhelm | Fifth | 5½ out |
| Wednesday, June 8 |
| » Defeated Orioles (29-19), 2-0 | Memorial Stadium (2-0) | 22-21 | Won 2 |
| » Starters: Frank Lary vs Jack Fisher | Fifth | 4½ out |
| Thursday, June 9 |
| » Defeated Orioles (29-20), 7-5 | Memorial Stadium (3-0) | 23-21 | Won 3 |
| » Starters: Paul Foytack vs Milt Pappas | Fourth | 4 out |
| » Defeated Orioles (29-21), 7-4 | Memorial Stadium (4-0) | 24-21 | Won 4 |
| » Starters: Pete Burnside vs Hal Brown | Fourth | 4 out |
| Friday, June 10 |
| » Defeated Senators (20-27), 7-4 | Griffith Stadium (3-0) | 25-21 | Won 5 |
| » Starters: Jim Bunning vs Chuck Stobbs | Fourth | 3 out |
| Saturday, June 11 |
| » Lost to Senators (21-27), 8-7 | Griffith Stadium (3-1) | 25-22 | |
| » Starters: Don Mossi vs Bill Fischer | Fifth | 3½ out |
| Sunday, June 12 |
| » Lost to Senators (22-27), 8-3 | Griffith Stadium (3-2) | 25-23 | Lost 2 |
| » Starters: Hank Aguirre vs Camilo Pascual | Fourth | 3 out |
| » Defeated Senators (22-28), 12-5 | Griffith Stadium (4-2) | 26-23 | |
| » Starters: Frank Lary vs Hal Woodeshick | Fourth | 3 out |
| Tuesday, June 14 |
| » Defeated Red Sox (17-33), 2-1 | Tiger Stadium (15-7) | 27-23 | Won 2 |
| » Starters: Bill Monbouquette vs Jim Bunning | Fourth | 2 out |
| Future Tiger Mike Laga is born in Ridgewood, NJ. |
| Wednesday, June 15 |
| » Lost to Red Sox (18-33), 4-3 | Tiger Stadium (15-8) | 27-24 | |
| » Starters: Tom Brewer vs Don Mossi | Fourth | 2½ out |
| Thursday, June 16 |
| » Defeated Red Sox (18-34), 6-5 | Tiger Stadium (16-8) | 28-24 | |
| » Starters: Jerry Casale vs Paul Foytack | Fourth | 3 out |
| Friday, June 17 |
| » Lost to Orioles (35-24), 3-1 | Tiger Stadium (16-9) | 28-25 | |
| » Starters: Jerry Walker vs Frank Lary | Fifth | 4 out |
| Saturday, June 18 |
| » Defeated Orioles (35-25), 5-3 | Tiger Stadium (17-9) | 29-25 | |
| » Starters: Chuck Estrada vs Pete Burnside | Fourth | 2½ out |
| Sunday, June 19 |
| » Lost to Orioles (36-25), 2-0 | Tiger Stadium (17-10) | 29-26 | |
| » Starters: Hoyt Wilhelm vs Jim Bunning | Fourth | 4½ out |
| » Lost to Orioles (37-25), 1-0 | Tiger Stadium (17-11) | 29-27 | Lost 2 |
| » Starters: Milt Pappas vs Don Mossi | Fourth | 4½ out |
| Tuesday, June 21 |
| » Lost to Yankees (34-22), 6-0 | Tiger Stadium (17-12) | 29-28 | Lost 3 |
| » Starters: Whitey Ford vs Frank Lary | Fifth | 5½ out |
| Wednesday, June 22 |
| » Lost to Yankees (35-22), 7-3 | Tiger Stadium (17-13) | 29-29 | Lost 4 |
| » Starters: Art Ditmar vs Paul Foytack | Fifth | 6½ out |
| Thursday, June 23 |
| » Defeated Yankees (35-23), 2-1 | Tiger Stadium (18-13) | 30-29 | |
| » Starters: Bob Turley vs Don Mossi | Fifth | 5½ out |
| Friday, June 24 |
| » Defeated Senators (25-34), 4-0 | Tiger Stadium (19-13) | 31-29 | Won 2 |
| » Starters: Don Lee vs Jim Bunning | Fifth | 5½ out |
| Saturday, June 25 |
| » Lost to Senators (26-34), 6-4 | Tiger Stadium (19-14) | 31-30 | |
| » Starters: Hal Woodeshick vs Bob Bruce | Fifth | 5½ out |
| Sunday, June 26 |
| » Lost to Senators (27-34), 4-2 | Tiger Stadium (19-15) | 31-31 | Lost 2 |
| » Starters: Pedro Ramos vs Frank Lary | Fifth | 7½ out |
| » Lost to Senators (28-34), 7-4 | Tiger Stadium (19-16) | 31-32 | Lost 3 |
| » Starters: Bill Fischer vs Paul Foytack | Fifth | 7½ out |
| Tuesday, June 28 |
| » Defeated Red Sox (22-43), 10-1 | Fenway Park (1-2) | 32-32 | |
| » Starters: Don Mossi vs Ike Delock | Fifth | 6½ out |
| Wednesday, June 29 |
| » Lost to Red Sox (23-43), 4-2 | Fenway Park (1-3) | 32-33 | |
| » Starters: Jim Bunning vs Bill Monbouquette | Fifth | 7½ out |
| Thursday, June 30 |
| » Lost to Red Sox (24-43), 11-7 | Fenway Park (1-4) | 32-34 | Lost 2 |
| » Starters: Bob Bruce vs Tom Brewer | Fifth | 8½ out |
| Saturday, July 2 |
| » Lost to Yankees (41-25), 7-6 | Yankee Stadium (0-3) | 32-35 | Lost 3 |
| » Starters: Frank Lary vs Whitey Ford | Fifth | 9½ out |
| Sunday, July 3 |
| » Lost to Yankees (42-25), 7-6 | Yankee Stadium (0-4) | 32-36 | Lost 4 |
| » Starters: Don Mossi vs Bob Turley | Fifth | 11½ out |
| » Lost to Yankees (43-25), 6-2 | Yankee Stadium (0-5) | 32-37 | Lost 5 |
| » Starters: Pete Burnside vs Art Ditmar | Fifth | 11½ out |
| Monday, July 4 |
| » Defeated White Sox (39-33), 3-0 | Tiger Stadium (20-16) | 33-37 | |
| » Starters: Frank Baumann vs Jim Bunning | Fifth | 10 out |
| » Defeated White Sox (39-34), 3-2 | Tiger Stadium (21-16) | 34-37 | Won 2 |
| » Starters: Bob Shaw vs Bob Bruce | Fifth | 10 out |
| Wednesday, July 6 |
| » Lost to Athletics (28-45), 6-4 | Tiger Stadium (21-17) | 34-38 | |
| » Starters: Bud Daley vs Frank Lary | Fifth | 10½ out |
| Thursday, July 7 |
| » Defeated Athletics (28-46), 6-3 | Tiger Stadium (22-17) | 35-38 | |
| » Starters: Don Larsen vs Don Mossi | Fifth | 10½ out |
| Friday, July 8 |
| » Lost to Athletics (29-46), 5-4 | Municipal Stadium (0-6) | 35-39 | |
| » Starters: Jim Bunning vs Ray Herbert | Fifth | 10½ out |
| Saturday, July 9 |
| » Defeated Athletics (29-47), 6-1 | Municipal Stadium (1-6) | 36-39 | |
| » Starters: Pete Burnside vs Dick Hall | Fifth | 9½ out |
| Sunday, July 10 |
| » Defeated Athletics (29-48), 12-10 | Municipal Stadium (2-6) | 37-39 | Won 2 |
| » Starters: Frank Lary vs Bud Daley | Fifth | 8½ out |
| Friday, July 15 |
| » Defeated Yankees (45-31), 8-4 | Tiger Stadium (23-17) | 38-39 | Won 3 |
| » Starters: Art Ditmar vs Don Mossi | Fifth | 7½ out |
| Saturday, July 16 |
| » Lost to Yankees (46-31), 11-2 | Tiger Stadium (23-18) | 38-40 | |
| » Starters: Bob Turley vs Jim Bunning | Fifth | 8½ out |
| Sunday, July 17 |
| » Defeated Yankees (46-32), 12-2 | Tiger Stadium (24-18) | 39-40 | |
| » Starters: Ralph Terry vs Frank Lary | Fifth | 6½ out |
| » Defeated Yankees (46-33), 3-2 | Tiger Stadium (25-18) | 40-40 | Won 2 |
| » Starters: Eli Grba vs Pete Burnside | Fifth | 6½ out |
| Tuesday, July 19 |
| » Lost to Senators (40-41), 5-0 | Tiger Stadium (25-19) | 40-41 | |
| » Starters: Pedro Ramos vs Don Mossi | Fifth | 8 out |
| » Major-league debuts: Phil Regan (Tigers) |
| Wednesday, July 20 |
| » Lost to Senators (41-41), 8-6 | Tiger Stadium (25-20) | 40-42 | Lost 2 |
| » Starters: Hal Woodeshick vs Jim Bunning | Sixth | 8 out |
| Thursday, July 21 |
| » Defeated Senators (41-42), 9-5 | Tiger Stadium (26-20) | 41-42 | |
| » Starters: Tex Clevenger vs Frank Lary | Fifth | 7½ out |
| Friday, July 22 |
| » Lost to Orioles (49-42), 2-1 | Memorial Stadium (4-1) | 41-43 | |
| » Starters: Pete Burnside vs Steve Barber | Fifth | 7½ out |
| Saturday, July 23 |
| » Defeated Orioles (49-43), 4-1 | Memorial Stadium (5-1) | 42-43 | |
| » Starters: Hank Aguirre vs Jerry Walker | Sixth | 8 out |
| » Lost to Orioles (50-43), 4-3 | Memorial Stadium (5-2) | 42-44 | |
| » Starters: Phil Regan vs Hal Brown | Sixth | 8 out |
| Sunday, July 24 |
| » Lost to Orioles (51-43), 2-1 | Memorial Stadium (5-3) | 42-45 | Lost 2 |
| » Starters: Jim Bunning vs Chuck Estrada | Sixth | 8½ out |
| Future Tiger Jeff Kaiser is born in Wyandotte, MI. |
| Tuesday, July 26 |
| » Defeated Senators (43-45), 5-3 | Griffith Stadium (5-2) | 43-45 | |
| » Starters: Frank Lary vs Pedro Ramos | Fifth | 8½ out |
| Wednesday, July 27 |
| » Lost to Senators (44-45), 5-4 | Griffith Stadium (5-3) | 43-46 | |
| » Starters: Pete Burnside vs Jack Kralick | Sixth | 9½ out |
| Thursday, July 28 |
| » Lost to Senators (45-45), 6-5 | Griffith Stadium (5-4) | 43-47 | Lost 2 |
| » Starters: Phil Regan vs Tex Clevenger | Sixth | 9½ out |
| Former Tiger Marty Kavanagh dies in Taylor, MI at the age of 70. |
| Friday, July 29 |
| » Lost to Red Sox (38-54), 1-0 | Fenway Park (1-5) | 43-48 | Lost 3 |
| » Starters: Jim Bunning vs Bill Monbouquette | Sixth | 9½ out |
| Sunday, July 31 |
| » Defeated Red Sox (38-55), 9-6 | Fenway Park (2-5) | 44-48 | |
| » Starters: Frank Lary vs Frank Sullivan | Sixth | 11 out |
| » Lost to Red Sox (39-55), 8-4 | Fenway Park (2-6) | 44-49 | |
| » Starters: Phil Regan vs Billy Muffett | Sixth | 11 out |
| Monday, August 1 |
| » Lost to Yankees (54-39), 3-2 | Yankee Stadium (0-6) | 44-50 | Lost 2 |
| » Starters: Pete Burnside vs Ralph Terry | Sixth | 11 out |
| Tuesday, August 2 |
| » Lost to Yankees (55-39), 3-2 | Yankee Stadium (0-7) | 44-51 | Lost 3 |
| » Starters: Don Mossi vs Bob Turley | Sixth | 12½ out |
| » Lost to Yankees (56-39), 3-2 | Yankee Stadium (0-8) | 44-52 | Lost 4 |
| » Starters: Jim Bunning vs Whitey Ford | Sixth | 12½ out |
| Wednesday, August 3 |
| » Defeated Yankees (56-40), 12-2 | Yankee Stadium (1-8) | 45-52 | |
| » Manager: Billy Hitchcock |
| » Starters: Hank Aguirre vs Jim Coates | Sixth | 11½ out |
| Friday, August 5 |
| » Lost to Red Sox (42-57), 4-2 | Tiger Stadium (26-21) | 45-53 | |
| » Manager: Joe Gordon |
| » Starters: Ike Delock vs Frank Lary | Sixth | 12½ out |
| Saturday, August 6 |
| » Lost to Red Sox (43-57), 11-9 | Tiger Stadium (26-22) | 45-54 | Lost 2 |
| » Starters: Frank Sullivan vs Pete Burnside | Sixth | 13½ out |
| Sunday, August 7 |
| » Defeated Red Sox (43-58), 7-2 | Tiger Stadium (27-22) | 46-54 | |
| » Starters: Tom Brewer vs Jim Bunning | Sixth | 13½ out |
| » Lost to Red Sox (44-58), 1-0 | Tiger Stadium (27-23) | 46-55 | |
| » Starters: Billy Muffett vs Bob Bruce | Sixth | 13½ out |
| Tuesday, August 9 |
| » Lost to Orioles (61-46), 3-0 | Tiger Stadium (27-24) | 46-56 | Lost 2 |
| » Starters: Chuck Estrada vs Frank Lary | Fifth | 14 out |
| Wednesday, August 10 |
| » Lost to Orioles (62-46), 4-2 | Tiger Stadium (27-25) | 46-57 | Lost 3 |
| » Starters: Jerry Walker vs Pete Burnside | Sixth | 15 out |
| Thursday, August 11 |
| » Lost to Orioles (63-46), 6-1 | Tiger Stadium (27-26) | 46-58 | Lost 4 |
| » Starters: Jack Fisher vs Don Mossi | Sixth | 15½ out |
| Future Tiger Al Pedrique is born in Aragua, Venezuela. |
| Friday, August 12 |
| » Defeated Indians (52-52), 6-4 | Cleveland Stadium (5-2) | 47-58 | |
| » Starters: Jim Bunning vs Mudcat Grant | Sixth | 14½ out |
| Saturday, August 13 |
| » Lost to Indians (53-52), 2-1 | Cleveland Stadium (5-3) | 47-59 | |
| » Starters: Frank Lary vs Jim Perry | Sixth | 15½ out |
| Sunday, August 14 |
| » Defeated Indians (53-53), 6-1 | Cleveland Stadium (6-3) | 48-59 | |
| » Starters: Bill Fischer vs Dick Stigman | Fifth | 14 out |
| » Defeated Indians (53-54), 3-2 | Cleveland Stadium (7-3) | 49-59 | Won 2 |
| » Starters: Paul Foytack vs Barry Latman | Fifth | 14 out |
| Monday, August 15 |
| » Defeated White Sox (65-48), 4-1 | Comiskey Park I (1-3) | 50-59 | Won 3 |
| » Starters: Bob Bruce vs Herb Score | Fifth | 13½ out |
| Tuesday, August 16 |
| » Lost to White Sox (66-48), 3-2 | Comiskey Park I (1-4) | 50-60 | |
| » Starters: Jim Bunning vs Frank Baumann | Sixth | 14½ out |
| Wednesday, August 17 |
| » Defeated Athletics (41-70), 5-2 | Tiger Stadium (28-26) | 51-60 | |
| » Starters: Ray Herbert vs Frank Lary | Sixth | 14½ out |
| Thursday, August 18 |
| » Defeated Athletics (41-71), 11-6 | Tiger Stadium (29-26) | 52-60 | Won 2 |
| » Starters: Bud Daley vs Pete Burnside | Fifth | 14½ out |
| Friday, August 19 |
| » Defeated Indians (56-55), 5-3 | Tiger Stadium (30-26) | 53-60 | Won 3 |
| » Starters: Bobby Locke vs Bill Fischer | Sixth | 13½ out |
| Saturday, August 20 |
| » Defeated Indians (56-56), 4-2 | Tiger Stadium (31-26) | 54-60 | Won 4 |
| » Starters: Barry Latman vs Bob Bruce | Sixth | 13½ out |
| Sunday, August 21 |
| » Defeated Indians (56-57), 6-4 | Tiger Stadium (32-26) | 55-60 | Won 5 |
| » Starters: Jim Perry vs Jim Bunning | Fifth | 12 out |
| » Defeated Indians (56-58), 6-4 | Tiger Stadium (33-26) | 56-60 | Won 6 |
| » Starters: Gary Bell vs Frank Lary | Fifth | 12 out |
| Tuesday, August 23 |
| » Defeated Orioles (68-52), 5-3 | Memorial Stadium (6-3) | 57-60 | Won 7 |
| » Starters: Phil Regan vs Milt Pappas | Sixth | 11 out |
| Wednesday, August 24 |
| » Lost to Orioles (69-52), 9-2 | Memorial Stadium (6-4) | 57-61 | |
| » Starters: Bob Bruce vs Jack Fisher | Fifth | 12 out |
| Thursday, August 25 |
| » Lost to Orioles (70-52), 9-3 | Memorial Stadium (6-5) | 57-62 | Lost 2 |
| » Starters: Frank Lary vs Chuck Estrada | Sixth | 12½ out |
| Friday, August 26 |
| » Lost to Senators (62-60), 5-4 | Griffith Stadium (5-5) | 57-63 | Lost 3 |
| » Starters: Jim Bunning vs Pedro Ramos | Sixth | 14 out |
| Saturday, August 27 |
| » Lost to Senators (63-60), 4-1 | Griffith Stadium (5-6) | 57-64 | Lost 4 |
| » Starters: Bob Bruce vs Don Lee | Sixth | 15½ out |
| Sunday, August 28 |
| » Defeated Yankees (72-49), 6-2 | Yankee Stadium (2-8) | 58-64 | |
| » Starters: Don Mossi vs Eli Grba | Sixth | 15½ out |
| » Lost to Yankees (73-49), 8-5 | Yankee Stadium (2-9) | 58-65 | |
| » Starters: Phil Regan vs Art Ditmar | Sixth | 15½ out |
| Tuesday, August 30 |
| » Lost to Red Sox (54-70), 5-4 | Fenway Park (2-7) | 58-66 | Lost 2 |
| » Starters: Frank Lary vs Bill Monbouquette | Sixth | 17 out |
| » Lost to Red Sox (55-70), 3-2 | Fenway Park (2-8) | 58-67 | Lost 3 |
| » Starters: Jim Bunning vs Earl Wilson | Sixth | 17 out |
| Future Tiger Randy O'Neal is born in Ashland, KY. |
| Wednesday, August 31 |
| » Defeated Red Sox (55-71), 4-2 | Fenway Park (3-8) | 59-67 | |
| » Starters: Bob Bruce vs Ike Delock | Sixth | 16½ out |
| Friday, September 2 |
| » Lost to White Sox (73-55), 7-5 | Comiskey Park I (1-5) | 59-68 | |
| » Starters: Phil Regan vs Herb Score | Sixth | 16½ out |
| Saturday, September 3 |
| » Lost to White Sox (74-55), 4-1 | Comiskey Park I (1-6) | 59-69 | Lost 2 |
| » Starters: Frank Lary vs Early Wynn | Sixth | 17½ out |
| Sunday, September 4 |
| » Defeated White Sox (74-56), 6-4 | Comiskey Park I (2-6) | 60-69 | |
| » Starters: Jim Bunning vs Frank Baumann | Sixth | 18 out |
| » Lost to White Sox (75-56), 5-4 | Comiskey Park I (2-7) | 60-70 | |
| » Starters: Bob Bruce vs Billy Pierce | Sixth | 18 out |
| Monday, September 5 |
| » Defeated Indians (64-66), 4-3 | Tiger Stadium (34-26) | 61-70 | |
| » Starters: Mudcat Grant vs Bill Fischer | Sixth | 18 out |
| » Lost to Indians (65-66), 4-2 | Tiger Stadium (34-27) | 61-71 | |
| » Starters: Barry Latman vs Paul Foytack | Sixth | 18 out |
| Tuesday, September 6 |
| » Lost to Indians (66-66), 10-8 | Tiger Stadium (34-28) | 61-72 | Lost 2 |
| » Starters: Bobby Locke vs Pete Burnside | Sixth | 18½ out |
| Wednesday, September 7 |
| » Lost to Red Sox (59-75), 5-4 | Tiger Stadium (34-29) | 61-73 | Lost 3 |
| » Starters: Frank Sullivan vs Frank Lary | Sixth | 18½ out |
| Thursday, September 8 |
| » Lost to Red Sox (60-75), 6-1 | Tiger Stadium (34-30) | 61-74 | Lost 4 |
| » Starters: Tom Brewer vs Jim Bunning | Sixth | 19½ out |
| Friday, September 9 |
| » Lost to Yankees (79-55), 4-1 | Tiger Stadium (34-31) | 61-75 | Lost 5 |
| » Starters: Bill Stafford vs Bob Bruce | Sixth | 19½ out |
| Saturday, September 10 |
| » Lost to Yankees (80-55), 5-1 | Tiger Stadium (34-32) | 61-76 | Lost 6 |
| » Starters: Bob Turley vs Paul Foytack | Sixth | 20 out |
| Sunday, September 11 |
| » Defeated Senators (70-68), 8-3 | Tiger Stadium (35-32) | 62-76 | |
| » Starters: Chuck Stobbs vs Frank Lary | Sixth | 20 out |
| » Defeated Senators (70-69), 8-5 | Tiger Stadium (36-32) | 63-76 | Won 2 |
| » Starters: Don Lee vs Bill Fischer | Sixth | 20 out |
| Tuesday, September 13 |
| » Defeated Orioles (82-58), 3-1 | Tiger Stadium (37-32) | 64-76 | Won 3 |
| » Starters: Milt Pappas vs Jim Bunning | Sixth | 19 out |
| » Major-league debuts: Ray Barker (Orioles) |
| Wednesday, September 14 |
| » Lost to Orioles (83-58), 11-10 | Tiger Stadium (37-33) | 64-77 | |
| » Starters: Jack Fisher vs Bob Bruce | Sixth | 19 out |
| Friday, September 16 |
| » Defeated White Sox (81-61), 4-3 | Tiger Stadium (38-33) | 65-77 | |
| » Starters: Early Wynn vs Frank Lary | Sixth | 19 out |
| Future Tiger Mickey Tettleton is born in Oklahoma City, OK. |
| Saturday, September 17 |
| » Lost to White Sox (82-61), 8-4 | Tiger Stadium (38-34) | 65-78 | |
| » Starters: Billy Pierce vs Bill Fischer | Sixth | 20 out |
| » Major-league debuts: Dick McAuliffe (Tigers) |
| Sunday, September 18 |
| » Lost to White Sox (83-61), 8-4 | Tiger Stadium (38-35) | 65-79 | Lost 2 |
| » Starters: Frank Baumann vs Jim Bunning | Fourth | 21 out |
| » Defeated White Sox (83-62), 7-6 | Tiger Stadium (39-35) | 66-79 | |
| » Starters: Russ Kemmerer vs Bob Bruce | Fourth | 21 out |
| » Major-league debuts: Stan Johnson (White Sox) |
| Future Tiger Scott Earl is born in Seymour, IN. |
| Tuesday, September 20 |
| » Defeated Indians (72-73), 9-1 | Cleveland Stadium (8-3) | 67-79 | Won 2 |
| » Starters: Frank Lary vs Jim Perry | Fifth | 21 out |
| Wednesday, September 21 |
| » Major-league debuts: Leo Posada (Athletics) |
| Thursday, September 22 |
| » Major-league debuts: Dick Bertell (Cubs) |
| Friday, September 23 |
| » Lost to Athletics (53-93), 4-1 | Tiger Stadium (39-36) | 67-80 | |
| » Starters: Ned Garver vs Jim Bunning | Sixth | 22½ out |
| Saturday, September 24 |
| » Lost to Athletics (54-93), 6-3 | Tiger Stadium (39-37) | 67-81 | Lost 2 |
| » Starters: Dick Hall vs Bob Bruce | Sixth | 23½ out |
| Sunday, September 25 |
| » Defeated Athletics (54-94), 6-5 | Tiger Stadium (40-37) | 68-81 | |
| » Starters: Johnny Kucks vs Frank Lary | Sixth | 23½ out |
| Monday, September 26 |
| » Lost to White Sox (86-64), 6-3 | Comiskey Park I (2-8) | 68-82 | |
| » Starters: Bill Fischer vs Frank Baumann | Fifth | 24½ out |
| Tuesday, September 27 |
| » Defeated White Sox (86-65), 2-0 | Comiskey Park I (3-8) | 69-82 | |
| » Starters: Jim Bunning vs Early Wynn | Sixth | 24½ out |
| Thursday, September 29 |
| Future Tiger Rob Deer is born in Orange, CA. |
| Friday, September 30 |
| » Defeated Athletics (57-95), 5-3 | Municipal Stadium (3-6) | 70-82 | Won 2 |
| » Starters: Frank Lary vs Dick Hall | Fifth | 25 out |
| Saturday, October 1 |
| » Defeated Athletics (57-96), 6-4 | Municipal Stadium (4-6) | 71-82 | Won 3 |
| » Starters: Bob Bruce vs Bud Daley | Sixth | 25 out |
| Sunday, October 2 |
| » Lost to Athletics (58-96), 2-1 | Municipal Stadium (4-7) | 71-83 | |
| » Starters: Phil Regan vs Ray Herbert | Sixth | 26 out |
| Friday, October 21 |
| Future Tiger Franklin Stubbs is born in Richlands, NC. |
| Tuesday, November 29 |
| Future Tiger Howard Johnson is born in Clearwater, FL. |
| Thursday, December 22 |
| Former Tiger Jack Onslow dies in Concord, MA at the age of 73. |
| Wednesday, December 28 |
| Future Tiger Carl Willis is born in Danville, VA. |
Game information provided by Retrosheet (www.retrosheet.org) |
