| Monday, February 8 |
| Former Senator Punch Knoll dies in Evansville, IN at the age of 79. |
| Sunday, April 17 |
| » Major-league debuts: Chris Cannizzaro (Cardinals) |
| Former Senator Ricardo Torres dies in Regla, Cuba at the age of 70. |
| Monday, April 18 |
| » Defeated Red Sox (0-1), 10-1 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Tom Sturdivant vs Camilo Pascual | First | -- |
| » Major-league debuts: Don Mincher (Senators) |
| Tuesday, April 19 |
| » Lost to Orioles (1-0), 3-2 | Memorial Stadium (0-1) | 1-1 | |
| » Starters: Pedro Ramos vs Jerry Walker | Second | ½ out |
| » Major-league debuts: Marv Breeding (Orioles) |
| Wednesday, April 20 |
| » Defeated Orioles (1-1), 8-7 | Memorial Stadium (1-1) | 2-1 | |
| » Starters: Russ Kemmerer vs Milt Pappas | Third | ½ out |
| Thursday, April 21 |
| » Defeated Orioles (1-2), 6-5 | Memorial Stadium (2-1) | 3-1 | Won 2 |
| » Starters: Don Lee vs Steve Barber | Second | 1 out |
| » Major-league debuts: Chuck Estrada (Orioles) |
| Friday, April 22 |
| » Lost to Red Sox (2-3), 5-4 | Griffith Stadium (1-1) | 3-2 | |
| » Starters: Frank Sullivan vs Jim Kaat | Fourth | 1 out |
| » Major-league debuts: Lu Clinton (Red Sox) |
| Saturday, April 23 |
| » Lost to Red Sox (3-3), 8-3 | Griffith Stadium (1-2) | 3-3 | Lost 2 |
| » Starters: Tom Brewer vs Camilo Pascual | Fourth | 2 out |
| Sunday, April 24 |
| » Defeated Red Sox (3-4), 11-10 | Griffith Stadium (2-2) | 4-3 | |
| » Starters: Tom Sturdivant vs Pedro Ramos | Third | 2 out |
| Monday, April 25 |
| » Lost to Orioles (2-5), 3-2 | Griffith Stadium (2-3) | 4-4 | |
| » Starters: Milt Pappas vs Russ Kemmerer | Fourth | 2½ out |
| Tuesday, April 26 |
| » Lost to Orioles (3-5), 11-10 | Griffith Stadium (2-4) | 4-5 | Lost 2 |
| » Starters: Jerry Walker vs Don Lee | Fourth | 2½ out |
| Wednesday, April 27 |
| » Defeated Yankees (5-3), 5-4 | Yankee Stadium (1-0) | 5-5 | |
| » Starters: Jim Kaat vs Whitey Ford | Fourth | 1½ out |
| Saturday, April 30 |
| » Lost to Red Sox (5-6), 2-1 | Fenway Park (0-1) | 5-6 | |
| » Starters: Camilo Pascual vs Tom Sturdivant | Fourth | 1½ out |
| Monday, May 2 |
| » Lost to Indians (7-5), 3-2 | Griffith Stadium (2-5) | 5-7 | Lost 2 |
| » Starters: Gary Bell vs Pedro Ramos | Fifth | 2 out |
| Tuesday, May 3 |
| » Defeated Indians (7-6), 7-6 | Griffith Stadium (3-5) | 6-7 | |
| » Starters: Jim Perry vs Jim Kaat | Sixth | 2 out |
| Wednesday, May 4 |
| » Defeated Indians (7-7), 7-6 | Griffith Stadium (4-5) | 7-7 | Won 2 |
| » Starters: Barry Latman vs Don Lee | Fourth | 1½ out |
| Thursday, May 5 |
| » Lost to White Sox (9-6), 5-3 | Griffith Stadium (4-6) | 7-8 | |
| » Starters: Bob Shaw vs Russ Kemmerer | Fifth | 2 out |
| Friday, May 6 |
| » Lost to White Sox (10-6), 3-0 | Griffith Stadium (4-7) | 7-9 | Lost 2 |
| » Starters: Herb Score vs Pedro Ramos | Sixth | 3 out |
| Former Senator Merlin Kopp dies in Sacramento, CA at the age of 69. |
| Saturday, May 7 |
| » Lost to White Sox (11-6), 6-4 | Griffith Stadium (4-8) | 7-10 | Lost 3 |
| » Starters: Dick Donovan vs Jim Kaat | Sixth | 4 out |
| Monday, May 9 |
| » Defeated Athletics (6-12), 8-1 | Griffith Stadium (5-8) | 8-10 | |
| » Starters: Ray Herbert vs Camilo Pascual | Sixth | 4 out |
| Tuesday, May 10 |
| » Lost to Tigers (6-10), 1-0 | Griffith Stadium (5-9) | 8-11 | |
| » Starters: Don Mossi vs Tex Clevenger | Sixth | 4 out |
| Wednesday, May 11 |
| » Lost to Tigers (7-10), 1-0 | Griffith Stadium (5-10) | 8-12 | Lost 2 |
| » Starters: Frank Lary vs Pedro Ramos | Seventh | 4½ out |
| Friday, May 13 |
| » Lost to Yankees (11-8), 7-3 | Griffith Stadium (5-11) | 8-13 | Lost 3 |
| » Starters: Whitey Ford vs Jim Kaat | Seventh | 5 out |
| Saturday, May 14 |
| » Defeated Yankees (11-9), 4-0 | Griffith Stadium (6-11) | 9-13 | |
| » Starters: Gabe Gabler vs Camilo Pascual | Seventh | 4 out |
| Sunday, May 15 |
| » Lost to Yankees (12-9), 11-2 | Griffith Stadium (6-12) | 9-14 | |
| » Starters: Art Ditmar vs Tex Clevenger | Sixth | 4½ out |
| Tuesday, May 17 |
| » Lost to Tigers (10-12), 3-1 | Tiger Stadium (0-1) | 9-15 | Lost 2 |
| » Starters: Pedro Ramos vs Frank Lary | Eighth | 5½ out |
| Wednesday, May 18 |
| » Defeated Tigers (10-13), 3-0 | Tiger Stadium (1-1) | 10-15 | |
| » Starters: Camilo Pascual vs Jim Bunning | Seventh | 5½ out |
| Thursday, May 19 |
| » Major-league debuts: Ray Sadecki (Cardinals) |
| Saturday, May 21 |
| » Lost to Athletics (12-17), 5-2 | Municipal Stadium (0-1) | 10-16 | |
| » Starters: Jim Kaat vs Dick Hall | Eighth | 7 out |
| Sunday, May 22 |
| » Defeated White Sox (18-11), 7-5 | Comiskey Park I (1-0) | 11-16 | |
| » Starters: Camilo Pascual vs Bob Shaw | Sixth | 5 out |
| » Defeated White Sox (18-12), 3-2 | Comiskey Park I (2-0) | 12-16 | Won 2 |
| » Starters: Pedro Ramos vs Billy Pierce | Sixth | 5 out |
| Tuesday, May 24 |
| » Lost to Indians (17-12), 7-2 | Cleveland Stadium (0-1) | 12-17 | |
| » Starters: Chuck Stobbs vs Mudcat Grant | Sixth | 5½ out |
| Wednesday, May 25 |
| » Lost to Indians (18-12), 1-0 | Cleveland Stadium (0-2) | 12-18 | Lost 2 |
| » Starters: Bill Fischer vs Jim Perry | Fifth | 6½ out |
| Thursday, May 26 |
| » Defeated Red Sox (11-18), 5-2 | Griffith Stadium (7-12) | 13-18 | |
| » Starters: Jerry Casale vs Pedro Ramos | Sixth | 5½ out |
| Friday, May 27 |
| » Lost to Red Sox (12-18), 4-3 | Griffith Stadium (7-13) | 13-19 | |
| » Starters: Tom Brewer vs Camilo Pascual | Sixth | 6½ out |
| Saturday, May 28 |
| » Lost to Yankees (17-15), 5-1 | Yankee Stadium (1-1) | 13-20 | Lost 2 |
| » Starters: Jim Kaat vs Jim Coates | Seventh | 7 out |
| Sunday, May 29 |
| » Lost to Yankees (18-15), 6-4 | Yankee Stadium (1-2) | 13-21 | Lost 3 |
| » Starters: Hal Woodeshick vs Bob Turley | Seventh | 8½ out |
| Monday, May 30 |
| » Defeated Yankees (18-16), 2-1 | Yankee Stadium (2-2) | 14-21 | |
| » Starters: Chuck Stobbs vs Art Ditmar | Seventh | 8½ out |
| » Lost to Yankees (19-16), 3-2 | Yankee Stadium (2-3) | 14-22 | |
| » Starters: Pedro Ramos vs Ralph Terry | Seventh | 8½ out |
| Tuesday, May 31 |
| » Lost to Red Sox (14-21), 5-1 | Fenway Park (0-2) | 14-23 | Lost 2 |
| » Starters: Bill Fischer vs Tom Brewer | Eighth | 9½ out |
| Thursday, June 2 |
| » Defeated Red Sox (14-22), 8-3 | Fenway Park (1-2) | 15-23 | |
| » Starters: Don Lee vs Ike Delock | Seventh | 9½ out |
| » Defeated Red Sox (14-23), 8-7 | Fenway Park (2-2) | 16-23 | Won 2 |
| » Starters: Jim Kaat vs Dave Hillman | Seventh | 9½ out |
| Friday, June 3 |
| » Defeated Orioles (27-16), 4-1 | Griffith Stadium (8-13) | 17-23 | Won 3 |
| » Starters: Milt Pappas vs Hal Woodeshick | Seventh | 8½ out |
| Saturday, June 4 |
| » Defeated Orioles (27-17), 7-1 | Memorial Stadium (3-1) | 18-23 | Won 4 |
| » Starters: Chuck Stobbs vs Steve Barber | Seventh | 7½ out |
| Sunday, June 5 |
| » Lost to Orioles (28-17), 6-5 | Griffith Stadium (8-14) | 18-24 | |
| » Starters: Jerry Walker vs Pedro Ramos | Sixth | 8½ out |
| Monday, June 6 |
| » Lost to Orioles (29-17), 6-1 | Memorial Stadium (3-2) | 18-25 | Lost 2 |
| » Starters: Jim Kaat vs Chuck Estrada | Seventh | 9½ out |
| Tuesday, June 7 |
| » Defeated Athletics (19-27), 7-2 | Griffith Stadium (9-14) | 19-25 | |
| » Starters: Ray Herbert vs Camilo Pascual | Sixth | 8½ out |
| Wednesday, June 8 |
| » Defeated Athletics (19-28), 8-6 | Griffith Stadium (10-14) | 20-25 | Won 2 |
| » Starters: Bud Daley vs Hal Woodeshick | Sixth | 7½ out |
| Thursday, June 9 |
| » Lost to Athletics (20-28), 7-2 | Griffith Stadium (10-15) | 20-26 | |
| » Starters: Ken Johnson vs Pedro Ramos | Sixth | 8½ out |
| Friday, June 10 |
| » Lost to Tigers (25-21), 7-4 | Griffith Stadium (10-16) | 20-27 | Lost 2 |
| » Starters: Jim Bunning vs Chuck Stobbs | Sixth | 8½ out |
| Saturday, June 11 |
| » Defeated Tigers (25-22), 8-7 | Griffith Stadium (11-16) | 21-27 | |
| » Starters: Don Mossi vs Bill Fischer | Sixth | 8 out |
| Sunday, June 12 |
| » Defeated Tigers (25-23), 8-3 | Griffith Stadium (12-16) | 22-27 | Won 2 |
| » Starters: Hank Aguirre vs Camilo Pascual | Sixth | 7½ out |
| » Lost to Tigers (26-23), 12-5 | Griffith Stadium (12-17) | 22-28 | |
| » Starters: Frank Lary vs Hal Woodeshick | Sixth | 7½ out |
| Wednesday, June 15 |
| » Lost to White Sox (29-25), 6-4 | Comiskey Park I (2-1) | 22-29 | Lost 2 |
| » Starters: Pedro Ramos vs Russ Kemmerer | Fifth | 7½ out |
| Thursday, June 16 |
| » Lost to White Sox (30-25), 10-4 | Comiskey Park I (2-2) | 22-30 | Lost 3 |
| » Starters: Chuck Stobbs vs Frank Baumann | Fifth | 9 out |
| Friday, June 17 |
| » Defeated Athletics (23-33), 3-1 | Municipal Stadium (1-1) | 23-30 | |
| » Starters: Camilo Pascual vs Ray Herbert | Sixth | 9 out |
| Saturday, June 18 |
| » Defeated Athletics (23-34), 7-2 | Municipal Stadium (2-1) | 24-30 | Won 2 |
| » Starters: Hal Woodeshick vs Ken Johnson | Sixth | 7½ out |
| Sunday, June 19 |
| » Defeated Athletics (23-35), 6-5 | Municipal Stadium (3-1) | 25-30 | Won 3 |
| » Starters: Don Lee vs Johnny Kucks | Sixth | 8 out |
| Tuesday, June 21 |
| » Lost to Indians (31-25), 5-4 | Cleveland Stadium (0-3) | 25-31 | |
| » Starters: Pedro Ramos vs Mudcat Grant | Sixth | 9 out |
| Wednesday, June 22 |
| » Lost to Indians (32-25), 1-0 | Cleveland Stadium (0-4) | 25-32 | Lost 2 |
| » Starters: Bill Fischer vs Ted Bowsfield | Sixth | 10 out |
| Thursday, June 23 |
| » Lost to Indians (33-25), 7-6 | Cleveland Stadium (0-5) | 25-33 | Lost 3 |
| » Starters: Chuck Stobbs vs Barry Latman | Sixth | 10 out |
| Friday, June 24 |
| » Lost to Tigers (31-29), 4-0 | Tiger Stadium (1-2) | 25-34 | Lost 4 |
| » Starters: Don Lee vs Jim Bunning | Sixth | 11 out |
| Saturday, June 25 |
| » Defeated Tigers (31-30), 6-4 | Tiger Stadium (2-2) | 26-34 | |
| » Starters: Hal Woodeshick vs Bob Bruce | Sixth | 10 out |
| Sunday, June 26 |
| » Defeated Tigers (31-31), 4-2 | Tiger Stadium (3-2) | 27-34 | Won 2 |
| » Starters: Pedro Ramos vs Frank Lary | Sixth | 10 out |
| » Defeated Tigers (31-32), 7-4 | Tiger Stadium (4-2) | 28-34 | Won 3 |
| » Starters: Bill Fischer vs Paul Foytack | Sixth | 10 out |
| Monday, June 27 |
| » Defeated Orioles (41-28), 5-2 | Memorial Stadium (4-2) | 29-34 | Won 4 |
| » Starters: Jack Kralick vs Jack Fisher | Sixth | 8½ out |
| Tuesday, June 28 |
| » Defeated White Sox (36-31), 2-1 | Griffith Stadium (13-17) | 30-34 | Won 5 |
| » Starters: Frank Baumann vs Hal Woodeshick | Sixth | 8½ out |
| Wednesday, June 29 |
| » Major-league debuts: Joe Gaines (Reds) |
| Thursday, June 30 |
| » Lost to White Sox (37-31), 4-2 | Griffith Stadium (13-18) | 30-35 | |
| » Starters: Bob Shaw vs Pedro Ramos | Sixth | 10 out |
| Friday, July 1 |
| » Major-league debuts: Don Nottebart (Braves) |
| Saturday, July 2 |
| » Lost to Indians (38-28), 12-2 | Griffith Stadium (13-19) | 30-36 | Lost 2 |
| » Starters: Mudcat Grant vs Camilo Pascual | Sixth | 11 out |
| Sunday, July 3 |
| » Lost to Indians (39-28), 5-2 | Griffith Stadium (13-20) | 30-37 | Lost 3 |
| » Starters: Jim Perry vs Bill Fischer | Sixth | 13 out |
| » Lost to Indians (40-28), 11-5 | Griffith Stadium (13-21) | 30-38 | Lost 4 |
| » Starters: John Briggs vs Don Lee | Sixth | 13 out |
| Monday, July 4 |
| » Defeated Yankees (43-26), 9-8 | Griffith Stadium (14-21) | 31-38 | |
| » Starters: Jim Coates vs Hal Woodeshick | Sixth | 12 out |
| Tuesday, July 5 |
| » Defeated Yankees (43-27), 5-3 | Griffith Stadium (15-21) | 32-38 | Won 2 |
| » Starters: Ralph Terry vs Pedro Ramos | Sixth | 11 out |
| Wednesday, July 6 |
| » Defeated Red Sox (26-47), 4-0 | Fenway Park (3-2) | 33-38 | Won 3 |
| » Starters: Jack Kralick vs Jerry Casale | Sixth | 11 out |
| Thursday, July 7 |
| » Defeated Red Sox (26-48), 6-5 | Fenway Park (4-2) | 34-38 | Won 4 |
| » Starters: Camilo Pascual vs Frank Sullivan | Sixth | 11½ out |
| » Lost to Red Sox (27-48), 4-2 | Fenway Park (4-3) | 34-39 | |
| » Starters: Bill Fischer vs Billy Muffett | Sixth | 11½ out |
| Friday, July 8 |
| » Defeated Orioles (45-36), 9-5 | Memorial Stadium (5-2) | 35-39 | |
| » Starters: Pedro Ramos vs Jack Fisher | Fifth | 10½ out |
| Former Senator Joe Krakauskas dies in Hamilton, ON at the age of 46. |
| Saturday, July 9 |
| » Defeated Orioles (45-37), 7-2 | Memorial Stadium (6-2) | 36-39 | Won 2 |
| » Starters: Hal Woodeshick vs Hoyt Wilhelm | Fifth | 9½ out |
| Sunday, July 10 |
| » Defeated Orioles (45-38), 2-1 | Memorial Stadium (7-2) | 37-39 | Won 3 |
| » Starters: Jack Kralick vs Jerry Walker | Fifth | 8½ out |
| Friday, July 15 |
| » Lost to Indians (44-33), 4-0 | Cleveland Stadium (0-6) | 37-40 | |
| » Starters: Pedro Ramos vs Jim Perry | Sixth | 8½ out |
| Saturday, July 16 |
| » Lost to Indians (45-33), 9-4 | Cleveland Stadium (0-7) | 37-41 | Lost 2 |
| » Starters: Hal Woodeshick vs Gary Bell | Sixth | 9½ out |
| Sunday, July 17 |
| » Defeated Indians (45-34), 3-2 | Cleveland Stadium (1-7) | 38-41 | |
| » Starters: Tex Clevenger vs Mudcat Grant | Sixth | 7½ out |
| » Defeated Indians (45-35), 5-3 | Cleveland Stadium (2-7) | 39-41 | Won 2 |
| » Starters: Jack Kralick vs John Briggs | Sixth | 7½ out |
| Tuesday, July 19 |
| » Defeated Tigers (40-41), 5-0 | Tiger Stadium (5-2) | 40-41 | Won 3 |
| » Starters: Pedro Ramos vs Don Mossi | Fifth | 8 out |
| » Major-league debuts: Phil Regan (Tigers) |
| Wednesday, July 20 |
| » Defeated Tigers (40-42), 8-6 | Tiger Stadium (6-2) | 41-41 | Won 4 |
| » Starters: Hal Woodeshick vs Jim Bunning | Fifth | 7 out |
| Thursday, July 21 |
| » Lost to Tigers (41-42), 9-5 | Tiger Stadium (6-3) | 41-42 | |
| » Starters: Tex Clevenger vs Frank Lary | Fifth | 7½ out |
| Friday, July 22 |
| » Lost to Athletics (32-52), 9-4 | Griffith Stadium (15-22) | 41-43 | Lost 2 |
| » Starters: Dick Hall vs Hal Woodeshick | Fifth | 7½ out |
| Saturday, July 23 |
| » Defeated Athletics (32-53), 8-3 | Griffith Stadium (16-22) | 42-43 | |
| » Starters: Bud Daley vs Pedro Ramos | Fifth | 7½ out |
| Sunday, July 24 |
| » Lost to Athletics (33-53), 6-3 | Griffith Stadium (16-23) | 42-44 | |
| » Starters: Ray Herbert vs Tex Clevenger | Fifth | 7½ out |
| » Defeated Athletics (33-54), 10-2 | Griffith Stadium (17-23) | 43-44 | |
| » Starters: Ned Garver vs Camilo Pascual | Fifth | 7½ out |
| Tuesday, July 26 |
| » Lost to Tigers (43-45), 5-3 | Griffith Stadium (17-24) | 43-45 | |
| » Starters: Frank Lary vs Pedro Ramos | Fifth | 8½ out |
| Wednesday, July 27 |
| » Defeated Tigers (43-46), 5-4 | Griffith Stadium (18-24) | 44-45 | |
| » Starters: Pete Burnside vs Jack Kralick | Fifth | 8½ out |
| Thursday, July 28 |
| » Defeated Tigers (43-47), 6-5 | Griffith Stadium (19-24) | 45-45 | Won 2 |
| » Starters: Phil Regan vs Tex Clevenger | Fifth | 7½ out |
| Friday, July 29 |
| » Defeated White Sox (54-40), 7-5 | Griffith Stadium (20-24) | 46-45 | Won 3 |
| » Starters: Dick Donovan vs Camilo Pascual | Fifth | 6½ out |
| Saturday, July 30 |
| » Lost to White Sox (55-40), 3-2 | Griffith Stadium (20-25) | 46-46 | |
| » Starters: Frank Baumann vs Don Lee | Fifth | 7½ out |
| Sunday, July 31 |
| » Lost to White Sox (56-40), 5-2 | Griffith Stadium (20-26) | 46-47 | Lost 2 |
| » Starters: Early Wynn vs Pedro Ramos | Fifth | 9½ out |
| » Lost to White Sox (57-40), 9-5 | Griffith Stadium (20-27) | 46-48 | Lost 3 |
| » Starters: Bob Shaw vs Jack Kralick | Fifth | 9½ out |
| Monday, August 1 |
| » Lost to Indians (49-45), 3-0 | Griffith Stadium (20-28) | 46-49 | Lost 4 |
| » Starters: Jim Perry vs Hal Woodeshick | Fifth | 9½ out |
| Tuesday, August 2 |
| » Defeated Indians (49-46), 9-0 | Griffith Stadium (21-28) | 47-49 | |
| » Starters: Don Newcombe vs Camilo Pascual | Fifth | 9½ out |
| Wednesday, August 3 |
| » Lost to Indians (50-46), 7-4 | Griffith Stadium (21-29) | 47-50 | |
| » Starters: Mudcat Grant vs Jack Kralick | Fifth | 9½ out |
| Thursday, August 4 |
| » Defeated White Sox (57-44), 2-1 | Comiskey Park I (3-2) | 48-50 | |
| » Starters: Don Lee vs Early Wynn | Fifth | 9 out |
| Friday, August 5 |
| » Defeated White Sox (57-45), 6-1 | Comiskey Park I (4-2) | 49-50 | Won 2 |
| » Starters: Pedro Ramos vs Bob Shaw | Fifth | 9 out |
| Saturday, August 6 |
| » Lost to White Sox (58-45), 9-2 | Comiskey Park I (4-3) | 49-51 | |
| » Starters: Chuck Stobbs vs Herb Score | Fifth | 10 out |
| Sunday, August 7 |
| » Lost to White Sox (59-45), 9-7 | Comiskey Park I (4-4) | 49-52 | Lost 2 |
| » Starters: Camilo Pascual vs Frank Baumann | Fifth | 11 out |
| » Lost to White Sox (60-45), 3-2 | Comiskey Park I (4-5) | 49-53 | Lost 3 |
| » Starters: Tex Clevenger vs Bob Shaw | Fifth | 11 out |
| Monday, August 8 |
| » Defeated Athletics (39-62), 10-7 | Municipal Stadium (4-1) | 50-53 | |
| » Starters: Hal Woodeshick vs John Tsitouris | Fifth | 10 out |
| Tuesday, August 9 |
| » Defeated Athletics (39-63), 3-1 | Municipal Stadium (5-1) | 51-53 | Won 2 |
| » Starters: Don Lee vs Johnny Kucks | Fourth | 10½ out |
| » Lost to Athletics (40-63), 8-3 | Municipal Stadium (5-2) | 51-54 | |
| » Starters: Jack Kralick vs Don Larsen | Fourth | 10½ out |
| Wednesday, August 10 |
| » Lost to Athletics (41-63), 13-1 | Municipal Stadium (5-3) | 51-55 | Lost 2 |
| » Starters: Camilo Pascual vs Dick Hall | Fifth | 11½ out |
| Thursday, August 11 |
| » Defeated Athletics (41-64), 5-4 | Municipal Stadium (6-3) | 52-55 | |
| » Starters: Tex Clevenger vs Ray Herbert | Fifth | 11 out |
| Friday, August 12 |
| » Defeated Yankees (61-43), 12-7 | Yankee Stadium (3-3) | 53-55 | Won 2 |
| » Starters: Pedro Ramos vs Bill Short | Fifth | 10 out |
| Saturday, August 13 |
| » Lost to Yankees (62-43), 1-0 | Yankee Stadium (3-4) | 53-56 | |
| » Starters: Don Lee vs Whitey Ford | Fifth | 11 out |
| Sunday, August 14 |
| » Defeated Yankees (62-44), 5-4 | Yankee Stadium (4-4) | 54-56 | |
| » Starters: Camilo Pascual vs Bob Turley | Fourth | 9½ out |
| » Defeated Yankees (62-45), 6-3 | Yankee Stadium (5-4) | 55-56 | Won 2 |
| » Starters: Jack Kralick vs Eli Grba | Fourth | 9½ out |
| Monday, August 15 |
| » Lost to Red Sox (48-61), 11-3 | Griffith Stadium (21-30) | 55-57 | |
| » Starters: Earl Wilson vs Tex Clevenger | Fourth | 10 out |
| Tuesday, August 16 |
| » Defeated Red Sox (48-62), 8-5 | Griffith Stadium (22-30) | 56-57 | |
| » Starters: Ike Delock vs Pedro Ramos | Fifth | 10 out |
| Wednesday, August 17 |
| » Defeated Orioles (65-50), 11-7 | Memorial Stadium (8-2) | 57-57 | Won 2 |
| » Starters: Don Lee vs Jack Fisher | Fifth | 10 out |
| Thursday, August 18 |
| » Lost to Orioles (66-50), 10-8 | Memorial Stadium (8-3) | 57-58 | |
| » Starters: Jack Kralick vs Milt Pappas | Fourth | 11 out |
| Friday, August 19 |
| » Defeated Yankees (66-46), 4-2 | Griffith Stadium (23-30) | 58-58 | |
| » Starters: Art Ditmar vs Camilo Pascual | Fifth | 10 out |
| Saturday, August 20 |
| » Lost to Yankees (67-46), 9-5 | Griffith Stadium (23-31) | 58-59 | |
| » Starters: Bob Turley vs Pedro Ramos | Fifth | 11 out |
| Sunday, August 21 |
| » Defeated Yankees (67-47), 7-4 | Griffith Stadium (24-31) | 59-59 | |
| » Starters: Whitey Ford vs Don Lee | Third | 10 out |
| Tuesday, August 23 |
| » Defeated Athletics (42-74), 3-1 | Griffith Stadium (25-31) | 60-59 | Won 2 |
| » Starters: Dick Hall vs Jack Kralick | Fourth | 9 out |
| Wednesday, August 24 |
| » Lost to Athletics (43-74), 6-4 | Griffith Stadium (25-32) | 60-60 | |
| » Starters: Johnny Kucks vs Camilo Pascual | Fourth | 10 out |
| Thursday, August 25 |
| » Defeated Athletics (43-75), 9-0 | Griffith Stadium (26-32) | 61-60 | |
| » Starters: Don Larsen vs Chuck Stobbs | Fourth | 9½ out |
| Friday, August 26 |
| » Defeated Tigers (57-63), 5-4 | Griffith Stadium (27-32) | 62-60 | Won 2 |
| » Starters: Jim Bunning vs Pedro Ramos | Fourth | 10 out |
| Saturday, August 27 |
| » Defeated Tigers (57-64), 4-1 | Griffith Stadium (28-32) | 63-60 | Won 3 |
| » Starters: Bob Bruce vs Don Lee | Fourth | 10½ out |
| Sunday, August 28 |
| » Lost to Indians (59-63), 9-1 | Griffith Stadium (28-33) | 63-61 | |
| » Starters: Barry Latman vs Tex Clevenger | Fourth | 11 out |
| Monday, August 29 |
| » Lost to Indians (60-63), 6-4 | Griffith Stadium (28-34) | 63-62 | Lost 2 |
| » Starters: Mudcat Grant vs Camilo Pascual | Fourth | 11½ out |
| Tuesday, August 30 |
| » Lost to White Sox (72-54), 11-10 | Griffith Stadium (28-35) | 63-63 | Lost 3 |
| » Starters: Frank Baumann vs Pedro Ramos | Fourth | 12½ out |
| Wednesday, August 31 |
| » Defeated White Sox (72-55), 2-1 | Griffith Stadium (29-35) | 64-63 | |
| » Starters: Bob Shaw vs Jack Kralick | Fourth | 12 out |
| Friday, September 2 |
| » Defeated Red Sox (55-72), 5-1 | Fenway Park (5-3) | 65-63 | Won 2 |
| » Starters: Don Lee vs Frank Sullivan | Fourth | 10½ out |
| » Defeated Red Sox (55-73), 3-2 | Fenway Park (6-3) | 66-63 | Won 3 |
| » Starters: Pedro Ramos vs Billy Muffett | Fourth | 10½ out |
| » Major-league debuts: Ted Sadowski (Senators) |
| Saturday, September 3 |
| » Lost to Red Sox (56-73), 5-4 | Fenway Park (6-4) | 66-64 | |
| » Starters: Tex Clevenger vs Tom Brewer | Fourth | 11½ out |
| Sunday, September 4 |
| » Lost to Red Sox (57-73), 5-4 | Fenway Park (6-5) | 66-65 | Lost 2 |
| » Starters: Jack Kralick vs Earl Wilson | Fourth | 12½ out |
| Monday, September 5 |
| » Defeated Orioles (79-54), 4-0 | Griffith Stadium (30-35) | 67-65 | |
| » Starters: Steve Barber vs Chuck Stobbs | Fourth | 12½ out |
| » Lost to Orioles (80-54), 3-1 | Griffith Stadium (30-36) | 67-66 | |
| » Starters: Hal Brown vs Pedro Ramos | Fourth | 12½ out |
| Wednesday, September 7 |
| » Defeated Athletics (47-87), 5-3 | Municipal Stadium (7-3) | 68-66 | |
| » Starters: Don Lee vs Johnny Kucks | Fourth | 11½ out |
| Thursday, September 8 |
| » Defeated Athletics (47-88), 7-0 | Municipal Stadium (8-3) | 69-66 | Won 2 |
| » Starters: Jack Kralick vs Dick Hall | Fourth | 11½ out |
| Friday, September 9 |
| » Defeated Indians (67-68), 8-2 | Cleveland Stadium (3-7) | 70-66 | Won 3 |
| » Starters: Pedro Ramos vs Mudcat Grant | Fourth | 10½ out |
| Saturday, September 10 |
| » Lost to Indians (68-68), 5-4 | Cleveland Stadium (3-8) | 70-67 | |
| » Starters: Ted Sadowski vs Barry Latman | Fourth | 11 out |
| Sunday, September 11 |
| » Lost to Tigers (62-76), 8-3 | Tiger Stadium (6-4) | 70-68 | Lost 2 |
| » Starters: Chuck Stobbs vs Frank Lary | Fourth | 13 out |
| » Lost to Tigers (63-76), 8-5 | Tiger Stadium (6-5) | 70-69 | Lost 3 |
| » Starters: Don Lee vs Bill Fischer | Fourth | 13 out |
| Tuesday, September 13 |
| » Lost to White Sox (81-59), 6-5 | Comiskey Park I (4-6) | 70-70 | Lost 4 |
| » Starters: Pedro Ramos vs Bob Shaw | Fourth | 13 out |
| Wednesday, September 14 |
| » Defeated White Sox (81-60), 6-1 | Comiskey Park I (5-6) | 71-70 | |
| » Starters: Jack Kralick vs Herb Score | Fourth | 12 out |
| Friday, September 16 |
| » Defeated Red Sox (61-81), 3-0 | Griffith Stadium (31-36) | 72-70 | Won 2 |
| » Starters: Ike Delock vs Chuck Stobbs | Fourth | 12 out |
| Saturday, September 17 |
| » Lost to Red Sox (62-81), 2-1 | Griffith Stadium (31-37) | 72-71 | |
| » Starters: Billy Muffett vs Pedro Ramos | Fourth | 13 out |
| Sunday, September 18 |
| » Lost to Red Sox (63-81), 3-1 | Griffith Stadium (31-38) | 72-72 | Lost 2 |
| » Starters: Bill Monbouquette vs Don Lee | Third | 14½ out |
| Tuesday, September 20 |
| » Lost to Yankees (87-57), 2-1 | Yankee Stadium (5-5) | 72-73 | Lost 3 |
| » Starters: Jack Kralick vs Bill Stafford | Fourth | 15½ out |
| » Major-league debuts: Deron Johnson (Yankees) |
| Wednesday, September 21 |
| » Lost to Yankees (88-57), 10-3 | Yankee Stadium (5-6) | 72-74 | Lost 4 |
| » Starters: Pedro Ramos vs Whitey Ford | Fifth | 16½ out |
| Thursday, September 22 |
| » Major-league debuts: Dick Bertell (Cubs) |
| Friday, September 23 |
| » Defeated Orioles (84-64), 4-0 | Griffith Stadium (32-38) | 73-74 | |
| » Starters: Chuck Estrada vs Chuck Stobbs | Fourth | 16½ out |
| Saturday, September 24 |
| » Lost to Orioles (85-64), 10-9 | Griffith Stadium (32-39) | 73-75 | |
| » Starters: Jack Fisher vs Don Lee | Fifth | 17½ out |
| Sunday, September 25 |
| » Lost to Orioles (86-64), 3-1 | Griffith Stadium (32-40) | 73-76 | Lost 2 |
| » Starters: Milt Pappas vs Jack Kralick | Fifth | 18½ out |
| Monday, September 26 |
| » Lost to Yankees (92-57), 4-2 | Griffith Stadium (32-41) | 73-77 | Lost 3 |
| » Starters: Bill Stafford vs Pedro Ramos | Fourth | 19½ out |
| Tuesday, September 27 |
| » Lost to Yankees (93-57), 5-1 | Griffith Stadium (32-42) | 73-78 | Lost 4 |
| » Starters: Ryne Duren vs Don Lee | Fifth | 20½ out |
| Wednesday, September 28 |
| » Lost to Yankees (94-57), 6-3 | Griffith Stadium (32-43) | 73-79 | Lost 5 |
| » Starters: Whitey Ford vs Chuck Stobbs | Fifth | 21½ out |
| Saturday, October 1 |
| » Lost to Orioles (88-65), 3-2 | Griffith Stadium (32-44) | 73-80 | Lost 6 |
| » Starters: Chuck Estrada vs Jack Kralick | Fifth | 23 out |
| Sunday, October 2 |
| » Lost to Orioles (89-65), 2-1 | Griffith Stadium (32-45) | 73-81 | Lost 7 |
| » Starters: Milt Pappas vs Pedro Ramos | Fifth | 24 out |
| Wednesday, November 2 |
| Former Senator Everett Scott dies in Fort Wayne, IN at the age of 68. |
| Sunday, November 20 |
| Former Senator Frank Brower dies in Baltimore, MD at the age of 68. |
Game information provided by Retrosheet (www.retrosheet.org) |
