| Tuesday, January 12 |
| Future Red Sox Mike Marshall is born in Libertyville, IL. Future Red Sox Mike Trujillo is born in Denver, CO. |
| Tuesday, February 16 |
| Former Red Sox Stuffy McInnis dies in Ipswich, MA at the age of 70. |
| Wednesday, February 24 |
| Future Red Sox Nick Esasky is born in Hialeah, FL. |
| Tuesday, March 22 |
| Former Red Sox Gordon Rhodes dies in Long Beach, CA at the age of 53. |
| Wednesday, March 30 |
| Former Red Sox Joe Connolly dies in San Francisco, CA at the age of 64. |
| Saturday, April 2 |
| Future Red Sox Tom Barrett is born in San Fernando, CA. |
| Sunday, April 17 |
| » Major-league debuts: Chris Cannizzaro (Cardinals) |
| Monday, April 18 |
| » Lost to Senators (1-0), 10-1 | Griffith Stadium (0-1) | 0-1 | |
| » Starters: Tom Sturdivant vs Camilo Pascual | Third | 1 out |
| » Major-league debuts: Don Mincher (Senators) |
| Tuesday, April 19 |
| » Lost to Yankees (1-0), 8-4 | Fenway Park (0-1) | 0-2 | Lost 2 |
| » Starters: Jim Coates vs Tom Brewer | Fourth | 1½ out |
| Future Red Sox Frank Viola is born in Hempstead, NY. |
| Wednesday, April 20 |
| » Defeated Yankees (1-1), 7-1 | Fenway Park (1-1) | 1-2 | |
| » Starters: Bob Turley vs Jerry Casale | Fifth | 1½ out |
| Future Red Sox Randy Kutcher is born in Anchorage, AK. |
| Thursday, April 21 |
| » Lost to Yankees (2-1), 4-0 | Fenway Park (1-2) | 1-3 | |
| » Starters: Gabe Gabler vs Bill Monbouquette | Fifth | 2 out |
| Friday, April 22 |
| » Defeated Senators (3-2), 5-4 | Griffith Stadium (1-1) | 2-3 | |
| » Starters: Frank Sullivan vs Jim Kaat | Fifth | 2 out |
| » Major-league debuts: Lu Clinton (Red Sox) |
| Saturday, April 23 |
| » Defeated Senators (3-3), 8-3 | Griffith Stadium (2-1) | 3-3 | Won 2 |
| » Starters: Tom Brewer vs Camilo Pascual | Fourth | 2 out |
| Sunday, April 24 |
| » Lost to Senators (4-3), 11-10 | Griffith Stadium (2-2) | 3-4 | |
| » Starters: Tom Sturdivant vs Pedro Ramos | Fourth | 3 out |
| Tuesday, April 26 |
| » Defeated Yankees (5-2), 7-5 | Yankee Stadium (1-0) | 4-4 | |
| » Starters: Jerry Casale vs Gabe Gabler | Third | 2 out |
| Wednesday, April 27 |
| » Lost to Orioles (4-5), 8-3 | Memorial Stadium (0-1) | 4-5 | |
| » Starters: Frank Sullivan vs Arnie Portocarrero | Fifth | 2 out |
| Thursday, April 28 |
| » Lost to Orioles (5-5), 6-1 | Memorial Stadium (0-2) | 4-6 | Lost 2 |
| » Starters: Bill Monbouquette vs Steve Barber | Fifth | 2 out |
| Saturday, April 30 |
| » Defeated Senators (5-6), 2-1 | Fenway Park (2-2) | 5-6 | |
| » Starters: Camilo Pascual vs Tom Sturdivant | Fourth | 1½ out |
| Tuesday, May 3 |
| » Defeated Athletics (5-9), 4-3 | Fenway Park (3-2) | 6-6 | Won 2 |
| » Starters: Ray Herbert vs Jerry Casale | Fifth | 1½ out |
| Wednesday, May 4 |
| » Lost to Athletics (6-9), 5-3 | Fenway Park (3-3) | 6-7 | |
| » Starters: Dick Hall vs Tom Brewer | Fifth | 2 out |
| Friday, May 6 |
| » Defeated Tigers (5-9), 3-2 | Fenway Park (4-3) | 7-7 | |
| » Starters: Jim Bunning vs Frank Sullivan | Fourth | 2 out |
| Saturday, May 7 |
| » Defeated Tigers (5-10), 5-0 | Fenway Park (5-3) | 8-7 | Won 2 |
| » Starters: Paul Foytack vs Bill Monbouquette | Third | 2 out |
| Tuesday, May 10 |
| » Defeated White Sox (12-7), 9-7 | Fenway Park (6-3) | 9-7 | Won 3 |
| » Starters: Early Wynn vs Jerry Casale | Third | 1½ out |
| Thursday, May 12 |
| » Defeated White Sox (12-8), 1-0 | Fenway Park (7-3) | 10-7 | Won 4 |
| » Starters: Bob Shaw vs Tom Brewer | Second | 1½ out |
| Saturday, May 14 |
| » Lost to Orioles (12-10), 5-2 | Fenway Park (7-4) | 10-8 | |
| » Starters: Jerry Walker vs Bill Monbouquette | Third | 2 out |
| Sunday, May 15 |
| » Lost to Orioles (13-10), 2-1 | Fenway Park (7-5) | 10-9 | Lost 2 |
| » Starters: Steve Barber vs Jerry Casale | Fourth | 2 out |
| » Lost to Orioles (14-10), 7-4 | Fenway Park (7-6) | 10-10 | Lost 3 |
| » Starters: Hal Brown vs Frank Sullivan | Fourth | 2 out |
| » Major-league debuts: Tom Borland (Red Sox) |
| Tuesday, May 17 |
| » Lost to White Sox (15-10), 11-6 | Comiskey Park I (0-1) | 10-11 | Lost 4 |
| » Starters: Tom Brewer vs Bob Shaw | Fifth | 3 out |
| Wednesday, May 18 |
| » Lost to White Sox (16-10), 6-5 | Comiskey Park I (0-2) | 10-12 | Lost 5 |
| » Starters: Frank Sullivan vs Billy Pierce | Fifth | 4 out |
| Thursday, May 19 |
| » Major-league debuts: Ray Sadecki (Cardinals) |
| Friday, May 20 |
| » Lost to Indians (15-11), 2-0 | Cleveland Stadium (0-1) | 10-13 | Lost 6 |
| » Starters: Bill Monbouquette vs Mudcat Grant | Sixth | 5 out |
| Saturday, May 21 |
| » Lost to Indians (16-11), 6-1 | Cleveland Stadium (0-2) | 10-14 | Lost 7 |
| » Starters: Jerry Casale vs Jim Perry | Sixth | 6 out |
| Sunday, May 22 |
| » Lost to Tigers (12-14), 6-2 | Tiger Stadium (0-1) | 10-15 | Lost 8 |
| » Starters: Tom Brewer vs Jim Bunning | Eighth | 6 out |
| » Lost to Tigers (13-14), 5-2 | Tiger Stadium (0-2) | 10-16 | Lost 9 |
| » Starters: Frank Sullivan vs Hank Aguirre | Eighth | 6 out |
| Tuesday, May 24 |
| » Lost to Athletics (13-19), 6-2 | Municipal Stadium (0-1) | 10-17 | Lost 10 |
| » Starters: Dave Hillman vs Bud Daley | Eighth | 6½ out |
| Wednesday, May 25 |
| » Defeated Athletics (13-20), 5-3 | Municipal Stadium (1-1) | 11-17 | |
| » Starters: Bill Monbouquette vs Don Larsen | Seventh | 6½ out |
| Thursday, May 26 |
| » Lost to Senators (13-18), 5-2 | Griffith Stadium (2-3) | 11-18 | |
| » Starters: Jerry Casale vs Pedro Ramos | Eighth | 6½ out |
| Future Red Sox Rob Murphy is born in Miami, FL. |
| Friday, May 27 |
| » Defeated Senators (13-19), 4-3 | Griffith Stadium (3-3) | 12-18 | |
| » Starters: Tom Brewer vs Camilo Pascual | Seventh | 6½ out |
| Sunday, May 29 |
| » Lost to Orioles (22-14), 6-1 | Memorial Stadium (0-3) | 12-19 | |
| » Starters: Frank Sullivan vs Steve Barber | Eighth | 8½ out |
| » Lost to Orioles (23-14), 5-4 | Memorial Stadium (0-4) | 12-20 | Lost 2 |
| » Starters: Tom Borland vs Jack Fisher | Eighth | 8½ out |
| Monday, May 30 |
| » Lost to Orioles (24-14), 7-5 | Memorial Stadium (0-5) | 12-21 | Lost 3 |
| » Starters: Bill Monbouquette vs Chuck Estrada | Eighth | 8½ out |
| » Defeated Orioles (24-15), 12-3 | Memorial Stadium (1-5) | 13-21 | |
| » Starters: Ted Bowsfield vs Arnie Portocarrero | Eighth | 8½ out |
| Tuesday, May 31 |
| » Defeated Senators (14-23), 5-1 | Fenway Park (8-6) | 14-21 | Won 2 |
| » Starters: Bill Fischer vs Tom Brewer | Seventh | 8½ out |
| Thursday, June 2 |
| » Lost to Senators (15-23), 8-3 | Fenway Park (8-7) | 14-22 | |
| » Starters: Don Lee vs Ike Delock | Eighth | 10½ out |
| » Lost to Senators (16-23), 8-7 | Fenway Park (8-8) | 14-23 | Lost 2 |
| » Starters: Jim Kaat vs Dave Hillman | Eighth | 10½ out |
| Friday, June 3 |
| » Lost to Yankees (20-19), 4-3 | Yankee Stadium (1-1) | 14-24 | Lost 3 |
| » Starters: Jerry Casale vs Bob Turley | Eighth | 10½ out |
| Future Red Sox Steve Lyons is born in Tacoma, WA. |
| Saturday, June 4 |
| » Defeated Yankees (20-20), 8-2 | Yankee Stadium (2-1) | 15-24 | |
| » Starters: Bill Monbouquette vs Bill Short | Eighth | 9½ out |
| Sunday, June 5 |
| » Lost to Yankees (21-20), 5-4 | Yankee Stadium (2-2) | 15-25 | |
| » Starters: Tom Brewer vs Ralph Terry | Eighth | 11 out |
| » Lost to Yankees (22-20), 8-3 | Yankee Stadium (2-3) | 15-26 | Lost 2 |
| » Starters: Ted Bowsfield vs Art Ditmar | Eighth | 11 out |
| Tuesday, June 7 |
| » Lost to Indians (25-17), 12-3 | Fenway Park (8-9) | 15-27 | Lost 3 |
| » Starters: Mudcat Grant vs Jerry Casale | Eighth | 11½ out |
| Wednesday, June 8 |
| » Lost to Indians (26-17), 8-7 | Fenway Park (8-10) | 15-28 | Lost 4 |
| » Manager: Del Baker |
| » Starters: Jim Perry vs Ike Delock | Eighth | 12 out |
| » Lost to Indians (27-17), 5-2 | Fenway Park (8-11) | 15-29 | Lost 5 |
| » Starters: Gary Bell vs Dave Hillman | Eighth | 12 out |
| Thursday, June 9 |
| » Lost to Indians (28-17), 3-2 | Fenway Park (8-12) | 15-30 | Lost 6 |
| » Starters: Wynn Hawkins vs Bill Monbouquette | Eighth | 13 out |
| Friday, June 10 |
| » Lost to White Sox (27-23), 13-3 | Fenway Park (8-13) | 15-31 | Lost 7 |
| » Starters: Russ Kemmerer vs Tom Brewer | Eighth | 13 out |
| Saturday, June 11 |
| » Defeated White Sox (27-24), 5-4 | Fenway Park (9-13) | 16-31 | |
| » Starters: Early Wynn vs Ike Delock | Eighth | 13 out |
| » Lost to White Sox (28-24), 8-4 | Fenway Park (9-14) | 16-32 | |
| » Starters: Billy Pierce vs Jerry Casale | Eighth | 13 out |
| Sunday, June 12 |
| » Defeated White Sox (28-25), 4-1 | Fenway Park (10-14) | 17-32 | |
| » Starters: Bob Shaw vs Frank Sullivan | Eighth | 12 out |
| Tuesday, June 14 |
| » Lost to Tigers (27-23), 2-1 | Tiger Stadium (0-3) | 17-33 | |
| » Manager: Pinky Higgins |
| » Starters: Bill Monbouquette vs Jim Bunning | Eighth | 12 out |
| Wednesday, June 15 |
| » Defeated Tigers (27-24), 4-3 | Tiger Stadium (1-3) | 18-33 | |
| » Starters: Tom Brewer vs Don Mossi | Seventh | 11½ out |
| Thursday, June 16 |
| » Lost to Tigers (28-24), 6-5 | Tiger Stadium (1-4) | 18-34 | |
| » Starters: Jerry Casale vs Paul Foytack | Seventh | 13 out |
| Friday, June 17 |
| » Defeated Indians (29-23), 3-1 | Cleveland Stadium (1-2) | 19-34 | |
| » Starters: Frank Sullivan vs Wynn Hawkins | Eighth | 13 out |
| Saturday, June 18 |
| » Lost to Indians (30-23), 2-1 | Cleveland Stadium (1-3) | 19-35 | |
| » Starters: Ike Delock vs Dick Stigman | Eighth | 12½ out |
| Sunday, June 19 |
| » Defeated Indians (30-24), 7-1 | Cleveland Stadium (2-3) | 20-35 | |
| » Starters: Bill Monbouquette vs Jim Perry | Eighth | 12½ out |
| » Defeated Indians (30-25), 3-2 | Cleveland Stadium (3-3) | 21-35 | Won 2 |
| » Starters: Tom Brewer vs Gary Bell | Eighth | 12½ out |
| Monday, June 20 |
| » Lost to Athletics (24-35), 9-6 | Municipal Stadium (1-2) | 21-36 | |
| » Starters: Tom Borland vs Dick Hall | Eighth | 13 out |
| Tuesday, June 21 |
| » Lost to Athletics (25-35), 11-7 | Municipal Stadium (1-3) | 21-37 | Lost 2 |
| » Starters: Jerry Casale vs Bud Daley | Eighth | 14 out |
| Wednesday, June 22 |
| » Lost to Athletics (26-35), 2-1 | Municipal Stadium (1-4) | 21-38 | Lost 3 |
| » Starters: Frank Sullivan vs Ray Herbert | Eighth | 15 out |
| Thursday, June 23 |
| » Defeated Athletics (26-36), 13-4 | Municipal Stadium (2-4) | 22-38 | |
| » Starters: Ike Delock vs Ken Johnson | Eighth | 14 out |
| Friday, June 24 |
| » Lost to White Sox (33-30), 2-1 | Comiskey Park I (0-3) | 22-39 | |
| » Starters: Bill Monbouquette vs Bob Shaw | Eighth | 15 out |
| Saturday, June 25 |
| » Lost to White Sox (34-30), 7-6 | Comiskey Park I (0-4) | 22-40 | Lost 2 |
| » Starters: Tom Brewer vs Russ Kemmerer | Eighth | 15 out |
| Sunday, June 26 |
| » Lost to White Sox (35-30), 4-3 | Comiskey Park I (0-5) | 22-41 | Lost 3 |
| » Starters: Frank Sullivan vs Billy Pierce | Eighth | 17 out |
| » Lost to White Sox (36-30), 21-7 | Comiskey Park I (0-6) | 22-42 | Lost 4 |
| » Starters: Tom Borland vs Early Wynn | Eighth | 17 out |
| Monday, June 27 |
| Future Red Sox Jackie Gutierrez is born in Cartagena, Colombia. |
| Tuesday, June 28 |
| » Lost to Tigers (32-32), 10-1 | Fenway Park (10-15) | 22-43 | Lost 5 |
| » Starters: Don Mossi vs Ike Delock | Eighth | 17 out |
| Wednesday, June 29 |
| » Defeated Tigers (32-33), 4-2 | Fenway Park (11-15) | 23-43 | |
| » Starters: Jim Bunning vs Bill Monbouquette | Eighth | 17 out |
| Thursday, June 30 |
| » Defeated Tigers (32-34), 11-7 | Fenway Park (12-15) | 24-43 | Won 2 |
| » Starters: Bob Bruce vs Tom Brewer | Eighth | 17 out |
| Friday, July 1 |
| » Major-league debuts: Don Nottebart (Braves) |
| Saturday, July 2 |
| » Lost to Athletics (27-42), 10-6 | Fenway Park (12-16) | 24-44 | |
| » Starters: Bud Daley vs Frank Sullivan | Eighth | 18 out |
| Sunday, July 3 |
| » Defeated Athletics (27-43), 13-2 | Fenway Park (13-16) | 25-44 | |
| » Starters: Dick Hall vs Ike Delock | Eighth | 18½ out |
| Monday, July 4 |
| » Defeated Orioles (43-33), 10-7 | Fenway Park (14-16) | 26-44 | Won 2 |
| » Starters: Steve Barber vs Bill Monbouquette | Eighth | 18 out |
| » Lost to Orioles (44-33), 8-6 | Fenway Park (14-17) | 26-45 | |
| » Starters: Jerry Walker vs Tom Borland | Eighth | 18 out |
| Tuesday, July 5 |
| » Lost to Orioles (45-33), 9-4 | Fenway Park (14-18) | 26-46 | Lost 2 |
| » Starters: Chuck Estrada vs Tom Brewer | Eighth | 18 out |
| Wednesday, July 6 |
| » Lost to Senators (33-38), 4-0 | Fenway Park (14-19) | 26-47 | Lost 3 |
| » Starters: Jack Kralick vs Jerry Casale | Eighth | 19 out |
| Thursday, July 7 |
| » Lost to Senators (34-38), 6-5 | Fenway Park (14-20) | 26-48 | Lost 4 |
| » Starters: Camilo Pascual vs Frank Sullivan | Eighth | 19½ out |
| » Defeated Senators (34-39), 4-2 | Fenway Park (15-20) | 27-48 | |
| » Starters: Bill Fischer vs Billy Muffett | Eighth | 19½ out |
| Friday, July 8 |
| » Defeated Yankees (45-28), 8-0 | Fenway Park (16-20) | 28-48 | Won 2 |
| » Starters: Art Ditmar vs Bill Monbouquette | Seventh | 18½ out |
| Saturday, July 9 |
| » Defeated Yankees (45-29), 6-5 | Fenway Park (17-20) | 29-48 | Won 3 |
| » Starters: Jim Coates vs Ike Delock | Seventh | 17½ out |
| Sunday, July 10 |
| » Defeated Yankees (45-30), 9-5 | Fenway Park (18-20) | 30-48 | Won 4 |
| » Starters: Ralph Terry vs Frank Sullivan | Sixth | 16½ out |
| Friday, July 15 |
| » Defeated Athletics (29-49), 2-1 | Municipal Stadium (3-4) | 31-48 | Won 5 |
| » Starters: Bill Monbouquette vs Bud Daley | Seventh | 15½ out |
| Saturday, July 16 |
| » Defeated Athletics (29-50), 1-0 | Municipal Stadium (4-4) | 32-48 | Won 6 |
| » Starters: Ike Delock vs Ray Herbert | Seventh | 15½ out |
| Sunday, July 17 |
| » Defeated Athletics (29-51), 4-2 | Municipal Stadium (5-4) | 33-48 | Won 7 |
| » Starters: Tom Brewer vs Dick Hall | Seventh | 14 out |
| Monday, July 18 |
| » Lost to White Sox (47-37), 9-1 | Comiskey Park I (0-7) | 33-49 | |
| » Starters: Billy Muffett vs Herb Score | Seventh | 15 out |
| Tuesday, July 19 |
| » Lost to White Sox (48-37), 6-0 | Comiskey Park I (0-8) | 33-50 | Lost 2 |
| » Starters: Frank Sullivan vs Billy Pierce | Sixth | 16 out |
| Wednesday, July 20 |
| » Lost to White Sox (49-37), 7-1 | Comiskey Park I (0-9) | 33-51 | Lost 3 |
| » Starters: Bill Monbouquette vs Russ Kemmerer | Seventh | 16 out |
| Friday, July 22 |
| » Defeated Indians (46-38), 6-4 | Fenway Park (19-20) | 34-51 | |
| » Starters: Mudcat Grant vs Ike Delock | Sixth | 15 out |
| » Major-league debuts: Mike de la Hoz (Indians) |
| Saturday, July 23 |
| » Lost to Indians (47-38), 4-2 | Fenway Park (19-21) | 34-52 | |
| » Starters: Jim Perry vs Tom Brewer | Seventh | 16 out |
| Sunday, July 24 |
| » Defeated Indians (47-39), 10-6 | Fenway Park (20-21) | 35-52 | |
| » Starters: Gary Bell vs Bill Monbouquette | Seventh | 15 out |
| » Defeated Indians (47-40), 7-6 | Fenway Park (21-21) | 36-52 | Won 2 |
| » Starters: Jack Harshman vs Frank Sullivan | Seventh | 15 out |
| Tuesday, July 26 |
| » Lost to White Sox (53-38), 16-3 | Fenway Park (21-22) | 36-53 | |
| » Starters: Early Wynn vs Jerry Casale | Sixth | 16 out |
| Wednesday, July 27 |
| » Lost to White Sox (54-38), 10-4 | Fenway Park (21-23) | 36-54 | Lost 2 |
| » Starters: Bob Shaw vs Ike Delock | Seventh | 17 out |
| Thursday, July 28 |
| » Defeated White Sox (54-39), 4-2 | Fenway Park (22-23) | 37-54 | |
| » Starters: Billy Pierce vs Tom Brewer | Seventh | 16 out |
| Friday, July 29 |
| » Defeated Tigers (43-48), 1-0 | Fenway Park (23-23) | 38-54 | Won 2 |
| » Starters: Jim Bunning vs Bill Monbouquette | Seventh | 15 out |
| Saturday, July 30 |
| Future Red Sox Steve Ellsworth is born in Chicago, IL. |
| Sunday, July 31 |
| » Lost to Tigers (44-48), 9-6 | Fenway Park (23-24) | 38-55 | |
| » Starters: Frank Lary vs Frank Sullivan | Seventh | 16½ out |
| » Defeated Tigers (44-49), 8-4 | Fenway Park (24-24) | 39-55 | |
| » Starters: Phil Regan vs Billy Muffett | Seventh | 16½ out |
| Monday, August 1 |
| » Lost to Athletics (37-56), 10-8 | Fenway Park (24-25) | 39-56 | |
| » Starters: Dick Hall vs Ike Delock | Seventh | 16½ out |
| Tuesday, August 2 |
| » Lost to Athletics (38-56), 10-4 | Fenway Park (24-26) | 39-57 | Lost 2 |
| » Starters: Ray Herbert vs Tom Brewer | Seventh | 17½ out |
| Thursday, August 4 |
| » Defeated Athletics (38-57), 5-3 | Fenway Park (25-26) | 40-57 | |
| » Starters: John Briggs vs Bill Monbouquette | Seventh | 16 out |
| » Defeated Athletics (38-58), 9-1 | Fenway Park (26-26) | 41-57 | Won 2 |
| » Starters: Don Larsen vs Earl Wilson | Seventh | 16 out |
| Friday, August 5 |
| » Defeated Tigers (45-53), 4-2 | Tiger Stadium (2-4) | 42-57 | Won 3 |
| » Starters: Ike Delock vs Frank Lary | Seventh | 16 out |
| Saturday, August 6 |
| » Defeated Tigers (45-54), 11-9 | Tiger Stadium (3-4) | 43-57 | Won 4 |
| » Starters: Frank Sullivan vs Pete Burnside | Seventh | 16 out |
| Sunday, August 7 |
| » Lost to Tigers (46-54), 7-2 | Tiger Stadium (3-5) | 43-58 | |
| » Starters: Tom Brewer vs Jim Bunning | Seventh | 16 out |
| » Defeated Tigers (46-55), 1-0 | Tiger Stadium (4-5) | 44-58 | |
| » Starters: Billy Muffett vs Bob Bruce | Seventh | 16 out |
| Tuesday, August 9 |
| » Lost to Indians (52-49), 6-3 | Cleveland Stadium (3-4) | 44-59 | |
| » Starters: Bill Monbouquette vs Jim Perry | Sixth | 16½ out |
| Wednesday, August 10 |
| » Defeated Indians (52-50), 6-1 | Cleveland Stadium (4-4) | 45-59 | |
| » Starters: Earl Wilson vs Barry Latman | Seventh | 16½ out |
| Thursday, August 11 |
| » Defeated Indians (52-51), 5-2 | Cleveland Stadium (5-4) | 46-59 | Won 2 |
| » Starters: Ike Delock vs Jack Harshman | Seventh | 16 out |
| Friday, August 12 |
| » Lost to Orioles (64-46), 4-3 | Memorial Stadium (1-6) | 46-60 | |
| » Starters: Billy Muffett vs Steve Barber | Seventh | 16 out |
| Saturday, August 13 |
| » Lost to Orioles (65-46), 8-7 | Memorial Stadium (1-7) | 46-61 | Lost 2 |
| » Starters: Tom Brewer vs Milt Pappas | Seventh | 17 out |
| Sunday, August 14 |
| » Defeated Orioles (65-47), 3-2 | Memorial Stadium (2-7) | 47-61 | |
| » Starters: Bill Monbouquette vs Steve Barber | Sixth | 16 out |
| Monday, August 15 |
| » Defeated Senators (55-57), 11-3 | Griffith Stadium (4-3) | 48-61 | Won 2 |
| » Starters: Earl Wilson vs Tex Clevenger | Sixth | 15½ out |
| Tuesday, August 16 |
| » Lost to Senators (56-57), 8-5 | Griffith Stadium (4-4) | 48-62 | |
| » Starters: Ike Delock vs Pedro Ramos | Seventh | 16½ out |
| Wednesday, August 17 |
| » Lost to Yankees (65-45), 3-2 | Fenway Park (26-27) | 48-63 | Lost 2 |
| » Starters: Bill Stafford vs Billy Muffett | Seventh | 17½ out |
| Thursday, August 18 |
| » Lost to Yankees (66-45), 11-7 | Fenway Park (26-28) | 48-64 | Lost 3 |
| » Starters: Eli Grba vs Tom Brewer | Sixth | 18½ out |
| Saturday, August 20 |
| » Defeated Orioles (66-51), 8-6 | Fenway Park (27-28) | 49-64 | |
| » Starters: Chuck Estrada vs Bill Monbouquette | Seventh | 18½ out |
| » Lost to Orioles (67-51), 6-0 | Fenway Park (27-29) | 49-65 | |
| » Starters: Hal Brown vs Earl Wilson | Seventh | 18½ out |
| Future Red Sox Tom Brunansky is born in Covina, CA. |
| Sunday, August 21 |
| » Lost to Orioles (68-51), 10-4 | Fenway Park (27-30) | 49-66 | Lost 2 |
| » Starters: Steve Barber vs Ike Delock | Sixth | 18½ out |
| Tuesday, August 23 |
| » Lost to Indians (57-58), 3-2 | Fenway Park (27-31) | 49-67 | Lost 3 |
| » Starters: Bobby Locke vs Billy Muffett | Seventh | 18½ out |
| Wednesday, August 24 |
| » Lost to Indians (58-58), 3-1 | Fenway Park (27-32) | 49-68 | Lost 4 |
| » Starters: Barry Latman vs Tom Brewer | Sixth | 19½ out |
| Thursday, August 25 |
| » Defeated Indians (58-59), 10-7 | Fenway Park (28-32) | 50-68 | |
| » Starters: Don Newcombe vs Bill Monbouquette | Seventh | 19 out |
| Friday, August 26 |
| » Lost to White Sox (70-52), 9-2 | Fenway Park (28-33) | 50-69 | |
| » Starters: Frank Baumann vs Earl Wilson | Seventh | 20½ out |
| Saturday, August 27 |
| » Lost to White Sox (71-52), 9-6 | Fenway Park (28-34) | 50-70 | Lost 2 |
| » Starters: Bob Shaw vs Ike Delock | Seventh | 22 out |
| Sunday, August 28 |
| » Defeated Athletics (44-78), 2-1 | Fenway Park (29-34) | 51-70 | |
| » Starters: Dick Hall vs Frank Sullivan | Seventh | 21 out |
| » Defeated Athletics (44-79), 5-4 | Fenway Park (30-34) | 52-70 | Won 2 |
| » Starters: Johnny Kucks vs Billy Muffett | Seventh | 21 out |
| Monday, August 29 |
| » Defeated Athletics (44-80), 4-1 | Fenway Park (31-34) | 53-70 | Won 3 |
| » Starters: Don Larsen vs Tom Brewer | Seventh | 20½ out |
| Tuesday, August 30 |
| » Defeated Tigers (58-66), 5-4 | Fenway Park (32-34) | 54-70 | Won 4 |
| » Starters: Frank Lary vs Bill Monbouquette | Seventh | 20 out |
| » Defeated Tigers (58-67), 3-2 | Fenway Park (33-34) | 55-70 | Won 5 |
| » Starters: Jim Bunning vs Earl Wilson | Seventh | 20 out |
| Wednesday, August 31 |
| » Lost to Tigers (59-67), 4-2 | Fenway Park (33-35) | 55-71 | |
| » Starters: Bob Bruce vs Ike Delock | Seventh | 20½ out |
| Friday, September 2 |
| » Lost to Senators (65-63), 5-1 | Fenway Park (33-36) | 55-72 | Lost 2 |
| » Starters: Don Lee vs Frank Sullivan | Seventh | 21 out |
| » Lost to Senators (66-63), 3-2 | Fenway Park (33-37) | 55-73 | Lost 3 |
| » Starters: Pedro Ramos vs Billy Muffett | Seventh | 21 out |
| » Major-league debuts: Ted Sadowski (Senators) |
| Saturday, September 3 |
| » Defeated Senators (66-64), 5-4 | Fenway Park (34-37) | 56-73 | |
| » Starters: Tex Clevenger vs Tom Brewer | Seventh | 21 out |
| Sunday, September 4 |
| » Defeated Senators (66-65), 5-4 | Fenway Park (35-37) | 57-73 | Won 2 |
| » Starters: Jack Kralick vs Earl Wilson | Seventh | 21 out |
| Monday, September 5 |
| » Lost to Yankees (76-53), 3-2 | Yankee Stadium (2-4) | 57-74 | |
| » Starters: Bill Monbouquette vs Bob Turley | Seventh | 22 out |
| » Lost to Yankees (77-53), 3-2 | Yankee Stadium (2-5) | 57-75 | Lost 2 |
| » Starters: Ike Delock vs Ralph Terry | Seventh | 22 out |
| Tuesday, September 6 |
| » Defeated Yankees (77-54), 7-1 | Yankee Stadium (3-5) | 58-75 | |
| » Starters: Billy Muffett vs Eli Grba | Seventh | 21½ out |
| Wednesday, September 7 |
| » Defeated Tigers (61-73), 5-4 | Tiger Stadium (5-5) | 59-75 | Won 2 |
| » Starters: Frank Sullivan vs Frank Lary | Seventh | 20½ out |
| Thursday, September 8 |
| » Defeated Tigers (61-74), 6-1 | Tiger Stadium (6-5) | 60-75 | Won 3 |
| » Starters: Tom Brewer vs Jim Bunning | Seventh | 20½ out |
| Friday, September 9 |
| » Lost to Athletics (48-88), 3-2 | Municipal Stadium (5-5) | 60-76 | |
| » Starters: Earl Wilson vs Bud Daley | Seventh | 20½ out |
| Saturday, September 10 |
| » Defeated Athletics (48-89), 7-4 | Municipal Stadium (6-5) | 61-76 | |
| » Starters: Ike Delock vs Ray Herbert | Sixth | 20 out |
| Sunday, September 11 |
| » Lost to White Sox (79-59), 5-3 | Comiskey Park I (0-10) | 61-77 | |
| » Starters: Bill Monbouquette vs Billy Pierce | Seventh | 22 out |
| » Lost to White Sox (80-59), 1-0 | Comiskey Park I (0-11) | 61-78 | Lost 2 |
| » Starters: Billy Muffett vs Early Wynn | Seventh | 22 out |
| Tuesday, September 13 |
| » Lost to Indians (69-70), 5-3 | Cleveland Stadium (5-5) | 61-79 | Lost 3 |
| » Starters: Tom Brewer vs Dick Stigman | Seventh | 22 out |
| Wednesday, September 14 |
| » Lost to Indians (70-70), 11-7 | Cleveland Stadium (5-6) | 61-80 | Lost 4 |
| » Starters: Frank Sullivan vs Barry Latman | Seventh | 22 out |
| » Major-league debuts: Ty Cline (Indians) |
| Friday, September 16 |
| » Lost to Senators (72-70), 3-0 | Griffith Stadium (4-5) | 61-81 | Lost 5 |
| » Starters: Ike Delock vs Chuck Stobbs | Seventh | 23 out |
| Saturday, September 17 |
| » Defeated Senators (72-71), 2-1 | Griffith Stadium (5-5) | 62-81 | |
| » Starters: Billy Muffett vs Pedro Ramos | Seventh | 23 out |
| Sunday, September 18 |
| » Defeated Senators (72-72), 3-1 | Griffith Stadium (6-5) | 63-81 | Won 2 |
| » Starters: Bill Monbouquette vs Don Lee | Fifth | 23½ out |
| Tuesday, September 20 |
| » Lost to Orioles (84-62), 4-3 | Memorial Stadium (2-8) | 63-82 | |
| » Starters: Tom Brewer vs Hal Brown | Sixth | 24½ out |
| Wednesday, September 21 |
| » Defeated Orioles (84-63), 4-1 | Memorial Stadium (3-8) | 64-82 | |
| » Starters: Ike Delock vs Steve Barber | Seventh | 24½ out |
| Thursday, September 22 |
| » Major-league debuts: Dick Bertell (Cubs) |
| Friday, September 23 |
| » Lost to Yankees (89-57), 5-1 | Fenway Park (35-38) | 64-83 | |
| » Starters: Bob Turley vs Billy Muffett | Seventh | 25½ out |
| » Major-league debuts: Jesse Gonder (Yankees) |
| Saturday, September 24 |
| » Lost to Yankees (90-57), 6-5 | Fenway Park (35-39) | 64-84 | Lost 2 |
| » Starters: Art Ditmar vs Bill Monbouquette | Seventh | 26½ out |
| » Major-league debuts: Tracy Stallard (Red Sox) |
| Sunday, September 25 |
| » Lost to Yankees (91-57), 4-3 | Fenway Park (35-40) | 64-85 | Lost 3 |
| » Starters: Ralph Terry vs Tom Brewer | Seventh | 27½ out |
| Tuesday, September 27 |
| » Lost to Orioles (87-64), 17-3 | Fenway Park (35-41) | 64-86 | Lost 4 |
| » Starters: Hal Brown vs Ike Delock | Seventh | 29 out |
| » Major-league debuts: Arnie Earley (Red Sox) |
| Wednesday, September 28 |
| » Defeated Orioles (87-65), 5-4 | Fenway Park (36-41) | 65-86 | |
| » Starters: Steve Barber vs Billy Muffett | Seventh | 29 out |
| Thursday, September 29 |
| Future Red Sox Rob Deer is born in Orange, CA. |
| Friday, September 30 |
| » Lost to Yankees (95-57), 6-5 | Yan |