| Tuesday, January 12 |
| Future Oriole Tim Hulett is born in Springfield, IL. |
| Monday, March 7 |
| Future Oriole Joe Carter is born in Oklahoma City, OK. |
| Tuesday, March 15 |
| Future Oriole Mike Pagliarulo is born in Medford, MA. |
| Sunday, March 20 |
| Future Oriole Mike Young is born in Oakland, CA. |
| Sunday, April 17 |
| » Major-league debuts: Chris Cannizzaro (Cardinals) |
| Monday, April 18 |
| » Major-league debuts: Don Mincher (Senators) |
| Tuesday, April 19 |
| » Defeated Senators (1-1), 3-2 | Memorial Stadium (1-0) | 1-0 | |
| » Starters: Pedro Ramos vs Jerry Walker | First | -- |
| » Major-league debuts: Marv Breeding (Orioles) |
| Wednesday, April 20 |
| » Lost to Senators (2-1), 8-7 | Memorial Stadium (1-1) | 1-1 | |
| » Starters: Russ Kemmerer vs Milt Pappas | Fourth | 1 out |
| Thursday, April 21 |
| » Lost to Senators (3-1), 6-5 | Memorial Stadium (1-2) | 1-2 | Lost 2 |
| » Starters: Don Lee vs Steve Barber | Fourth | 1½ out |
| » Major-league debuts: Chuck Estrada (Orioles) |
| Friday, April 22 |
| » Lost to Yankees (3-1), 5-0 | Yankee Stadium (0-1) | 1-3 | Lost 3 |
| » Starters: Hoyt Wilhelm vs Whitey Ford | Seventh | 2½ out |
| Saturday, April 23 |
| » Lost to Yankees (4-1), 3-2 | Yankee Stadium (0-2) | 1-4 | Lost 4 |
| » Starters: Rip Coleman vs Bill Short | Fifth | 3½ out |
| » Major-league debuts: Bill Short (Yankees) |
| Sunday, April 24 |
| » Lost to Yankees (5-1), 15-9 | Yankee Stadium (0-3) | 1-5 | Lost 5 |
| » Starters: Jack Fisher vs Jim Coates | Seventh | 4½ out |
| Monday, April 25 |
| » Defeated Senators (4-4), 3-2 | Griffith Stadium (1-0) | 2-5 | |
| » Starters: Milt Pappas vs Russ Kemmerer | Seventh | 4 out |
| Tuesday, April 26 |
| » Defeated Senators (4-5), 11-10 | Griffith Stadium (2-0) | 3-5 | Won 2 |
| » Starters: Jerry Walker vs Don Lee | Sixth | 3 out |
| Wednesday, April 27 |
| » Defeated Red Sox (4-5), 8-3 | Memorial Stadium (2-2) | 4-5 | Won 3 |
| » Starters: Frank Sullivan vs Arnie Portocarrero | Fifth | 2 out |
| Thursday, April 28 |
| » Defeated Red Sox (4-6), 6-1 | Memorial Stadium (3-2) | 5-5 | Won 4 |
| » Starters: Bill Monbouquette vs Steve Barber | Fourth | 1 out |
| Friday, April 29 |
| » Defeated Yankees (5-4), 2-1 | Memorial Stadium (4-2) | 6-5 | Won 5 |
| » Starters: Bill Short vs Hal Brown | Second | 1 out |
| Saturday, April 30 |
| » Lost to Yankees (6-4), 16-0 | Memorial Stadium (4-3) | 6-6 | |
| » Starters: Jim Coates vs Milt Pappas | Third | 1 out |
| Sunday, May 1 |
| » Defeated Yankees (6-5), 9-5 | Memorial Stadium (5-3) | 7-6 | |
| » Starters: Ralph Terry vs Chuck Estrada | Third | 1 out |
| Monday, May 2 |
| » Defeated White Sox (7-5), 11-6 | Memorial Stadium (6-3) | 8-6 | Won 2 |
| » Starters: Herb Score vs Jerry Walker | Second | 1 out |
| Tuesday, May 3 |
| » Lost to White Sox (8-5), 5-3 | Memorial Stadium (6-4) | 8-7 | |
| » Starters: Billy Pierce vs Steve Barber | Fourth | 1 out |
| Wednesday, May 4 |
| » Defeated White Sox (8-6), 6-4 | Memorial Stadium (7-4) | 9-7 | |
| » Starters: Early Wynn vs Hoyt Wilhelm | Third | 1½ out |
| Thursday, May 5 |
| » Lost to Indians (8-7), 11-6 | Memorial Stadium (7-5) | 9-8 | |
| » Starters: Wynn Hawkins vs Milt Pappas | Fourth | 2 out |
| Friday, May 6 |
| » Defeated Indians (8-8), 9-2 | Memorial Stadium (8-5) | 10-8 | |
| » Starters: Dick Stigman vs Hal Brown | Third | 2 out |
| Former Oriole Vern Bickford dies in Concord, VA at the age of 40. |
| Saturday, May 7 |
| » Lost to Indians (9-8), 3-1 | Memorial Stadium (8-6) | 10-9 | |
| » Starters: Gary Bell vs Chuck Estrada | Fifth | 2 out |
| Tuesday, May 10 |
| » Lost to Athletics (7-12), 10-0 | Memorial Stadium (8-7) | 10-10 | Lost 2 |
| » Starters: Dick Hall vs Hoyt Wilhelm | Fifth | 2½ out |
| Wednesday, May 11 |
| » Defeated Athletics (7-13), 5-3 | Memorial Stadium (9-7) | 11-10 | |
| » Starters: Bud Daley vs Arnie Portocarrero | Fifth | 2 out |
| Saturday, May 14 |
| » Defeated Red Sox (10-8), 5-2 | Fenway Park (1-0) | 12-10 | Won 2 |
| » Starters: Jerry Walker vs Bill Monbouquette | Fifth | 1 out |
| Sunday, May 15 |
| » Defeated Red Sox (10-9), 2-1 | Fenway Park (2-0) | 13-10 | Won 3 |
| » Starters: Steve Barber vs Jerry Casale | First | -- |
| » Defeated Red Sox (10-10), 7-4 | Fenway Park (3-0) | 14-10 | Won 4 |
| » Starters: Hal Brown vs Frank Sullivan | First | -- |
| » Major-league debuts: Tom Borland (Red Sox) |
| Monday, May 16 |
| » Defeated Athletics (9-16), 2-1 | Municipal Stadium (1-0) | 15-10 | Won 5 |
| » Starters: Arnie Portocarrero vs Ned Garver | First | -- |
| Tuesday, May 17 |
| » Lost to Athletics (10-16), 4-2 | Municipal Stadium (1-1) | 15-11 | |
| » Starters: Milt Pappas vs Don Larsen | Third | ½ out |
| Wednesday, May 18 |
| » Defeated Athletics (10-17), 5-4 | Municipal Stadium (2-1) | 16-11 | |
| » Starters: Hoyt Wilhelm vs Ray Herbert | Second | ½ out |
| Thursday, May 19 |
| » Lost to Athletics (11-17), 7-4 | Municipal Stadium (2-2) | 16-12 | |
| » Starters: Chuck Estrada vs Bud Daley | Second | 1 out |
| Friday, May 20 |
| » Lost to Tigers (11-13), 4-3 | Tiger Stadium (0-1) | 16-13 | Lost 2 |
| » Starters: Jerry Walker vs Don Mossi | Third | 2 out |
| Saturday, May 21 |
| » Defeated Tigers (11-14), 7-4 | Tiger Stadium (1-1) | 17-13 | |
| » Starters: Arnie Portocarrero vs Frank Lary | Third | 2 out |
| Sunday, May 22 |
| » Defeated Indians (16-12), 7-6 | Cleveland Stadium (1-0) | 18-13 | Won 2 |
| » Starters: Hal Brown vs Gary Bell | Second | ½ out |
| Tuesday, May 24 |
| » Defeated White Sox (18-13), 6-1 | Comiskey Park I (1-0) | 19-13 | Won 3 |
| » Starters: Steve Barber vs Herb Score | First | -- |
| » Major-league debuts: Dave Nicholson (Orioles) |
| Wednesday, May 25 |
| » Defeated White Sox (18-14), 3-2 | Comiskey Park I (2-0) | 20-13 | Won 4 |
| » Starters: Chuck Estrada vs Early Wynn | First | -- |
| Thursday, May 26 |
| » Lost to Yankees (16-14), 2-0 | Yankee Stadium (0-4) | 20-14 | |
| » Starters: Hal Brown vs Whitey Ford | Second | 2 out |
| Friday, May 27 |
| » Defeated Yankees (16-15), 3-2 | Yankee Stadium (1-4) | 21-14 | |
| » Starters: Hoyt Wilhelm vs Art Ditmar | First | -- |
| Sunday, May 29 |
| » Defeated Red Sox (12-19), 6-1 | Memorial Stadium (10-7) | 22-14 | Won 2 |
| » Starters: Frank Sullivan vs Steve Barber | First | -- |
| » Defeated Red Sox (12-20), 5-4 | Memorial Stadium (11-7) | 23-14 | Won 3 |
| » Starters: Tom Borland vs Jack Fisher | First | -- |
| Monday, May 30 |
| » Defeated Red Sox (12-21), 7-5 | Memorial Stadium (12-7) | 24-14 | Won 4 |
| » Starters: Bill Monbouquette vs Chuck Estrada | First | -- |
| » Lost to Red Sox (13-21), 12-3 | Memorial Stadium (12-8) | 24-15 | |
| » Starters: Ted Bowsfield vs Arnie Portocarrero | First | -- |
| Tuesday, May 31 |
| » Defeated Yankees (19-17), 3-2 | Memorial Stadium (13-8) | 25-15 | |
| » Starters: Whitey Ford vs Jerry Walker | First | -- |
| Wednesday, June 1 |
| » Defeated Yankees (19-18), 4-1 | Memorial Stadium (14-8) | 26-15 | Won 2 |
| » Starters: Duke Maas vs Hal Brown | First | -- |
| Thursday, June 2 |
| » Defeated Yankees (19-19), 6-5 | Memorial Stadium (15-8) | 27-15 | Won 3 |
| » Starters: Jim Coates vs Hoyt Wilhelm | First | -- |
| Friday, June 3 |
| » Lost to Senators (17-23), 4-1 | Griffith Stadium (2-1) | 27-16 | |
| » Starters: Milt Pappas vs Hal Woodeshick | First | -- |
| Saturday, June 4 |
| » Lost to Senators (18-23), 7-1 | Memorial Stadium (15-9) | 27-17 | Lost 2 |
| » Starters: Chuck Stobbs vs Steve Barber | First | -- |
| Sunday, June 5 |
| » Defeated Senators (18-24), 6-5 | Griffith Stadium (3-1) | 28-17 | |
| » Starters: Jerry Walker vs Pedro Ramos | First | -- |
| Monday, June 6 |
| » Defeated Senators (18-25), 6-1 | Memorial Stadium (16-9) | 29-17 | Won 2 |
| » Starters: Jim Kaat vs Chuck Estrada | First | -- |
| Tuesday, June 7 |
| » Lost to Tigers (21-21), 5-2 | Memorial Stadium (16-10) | 29-18 | |
| » Starters: Don Mossi vs Hoyt Wilhelm | First | -- |
| Wednesday, June 8 |
| » Lost to Tigers (22-21), 2-0 | Memorial Stadium (16-11) | 29-19 | Lost 2 |
| » Starters: Frank Lary vs Jack Fisher | Second | 2 out |
| Thursday, June 9 |
| » Lost to Tigers (23-21), 7-5 | Memorial Stadium (16-12) | 29-20 | Lost 3 |
| » Starters: Paul Foytack vs Milt Pappas | Second | 2½ out |
| » Lost to Tigers (24-21), 7-4 | Memorial Stadium (16-13) | 29-21 | Lost 4 |
| » Starters: Pete Burnside vs Hal Brown | Second | 2½ out |
| Friday, June 10 |
| » Defeated Athletics (20-29), 5-4 | Memorial Stadium (17-13) | 30-21 | |
| » Starters: Dick Hall vs Steve Barber | Second | 2½ out |
| Saturday, June 11 |
| » Defeated Athletics (20-30), 6-5 | Memorial Stadium (18-13) | 31-21 | Won 2 |
| » Starters: Ray Herbert vs Jerry Walker | First | -- |
| Sunday, June 12 |
| » Lost to Athletics (21-30), 6-1 | Memorial Stadium (18-14) | 31-22 | |
| » Starters: Bud Daley vs Chuck Estrada | Second | 3½ out |
| » Lost to Athletics (22-30), 5-3 | Memorial Stadium (18-15) | 31-23 | Lost 2 |
| » Starters: Bob Trowbridge vs Hoyt Wilhelm | Second | 3½ out |
| Tuesday, June 14 |
| » Defeated Indians (28-20), 7-4 | Cleveland Stadium (2-0) | 32-23 | |
| » Starters: Milt Pappas vs Gary Bell | Second | 3½ out |
| Wednesday, June 15 |
| » Lost to Indians (29-20), 10-2 | Cleveland Stadium (2-1) | 32-24 | |
| » Starters: Steve Barber vs Jim Perry | Second | 3½ out |
| » Defeated Indians (29-21), 13-5 | Cleveland Stadium (3-1) | 33-24 | |
| » Starters: Hal Brown vs Bobby Locke | Second | 3½ out |
| Thursday, June 16 |
| » Defeated Indians (29-22), 3-2 | Cleveland Stadium (4-1) | 34-24 | Won 2 |
| » Starters: Jack Fisher vs Ted Bowsfield | First | -- |
| Friday, June 17 |
| » Defeated Tigers (28-25), 3-1 | Tiger Stadium (2-1) | 35-24 | Won 3 |
| » Starters: Jerry Walker vs Frank Lary | First | -- |
| Saturday, June 18 |
| » Lost to Tigers (29-25), 5-3 | Tiger Stadium (2-2) | 35-25 | |
| » Starters: Chuck Estrada vs Pete Burnside | Second | 3½ out |
| Sunday, June 19 |
| » Defeated Tigers (29-26), 2-0 | Tiger Stadium (3-2) | 36-25 | |
| » Starters: Hoyt Wilhelm vs Jim Bunning | Second | 3½ out |
| » Defeated Tigers (29-27), 1-0 | Tiger Stadium (4-2) | 37-25 | Won 2 |
| » Starters: Milt Pappas vs Don Mossi | Second | 3½ out |
| Tuesday, June 21 |
| » Lost to White Sox (31-29), 4-3 | Comiskey Park I (2-1) | 37-26 | |
| » Starters: Steve Barber vs Billy Pierce | Second | 3½ out |
| Wednesday, June 22 |
| » Lost to White Sox (32-29), 3-1 | Comiskey Park I (2-2) | 37-27 | Lost 2 |
| » Starters: Jack Fisher vs Early Wynn | Second | 3½ out |
| Thursday, June 23 |
| » Defeated White Sox (32-30), 5-3 | Comiskey Park I (3-2) | 38-27 | |
| » Starters: Jerry Walker vs Frank Baumann | Second | 3½ out |
| Friday, June 24 |
| » Defeated Athletics (26-37), 6-5 | Municipal Stadium (3-2) | 39-27 | Won 2 |
| » Starters: Hal Brown vs Don Larsen | Second | 3½ out |
| Saturday, June 25 |
| » Defeated Athletics (26-38), 11-2 | Municipal Stadium (4-2) | 40-27 | Won 3 |
| » Starters: Milt Pappas vs Bud Daley | Second | 3½ out |
| Sunday, June 26 |
| » Defeated Athletics (26-39), 9-2 | Municipal Stadium (5-2) | 41-27 | Won 4 |
| » Starters: Chuck Estrada vs Dick Hall | First | -- |
| Monday, June 27 |
| » Lost to Senators (29-34), 5-2 | Memorial Stadium (18-16) | 41-28 | |
| » Starters: Jack Kralick vs Jack Fisher | Second | 3½ out |
| Future Oriole Jackie Gutierrez is born in Cartagena, Colombia. |
| Tuesday, June 28 |
| » Lost to Indians (36-27), 3-2 | Memorial Stadium (18-17) | 41-29 | Lost 2 |
| » Starters: Gary Bell vs Steve Barber | Second | 3½ out |
| Wednesday, June 29 |
| » Lost to Indians (37-27), 5-3 | Memorial Stadium (18-18) | 41-30 | Lost 3 |
| » Starters: Dick Stigman vs Jerry Walker | Third | 3½ out |
| Thursday, June 30 |
| » Defeated Indians (37-28), 9-1 | Memorial Stadium (19-18) | 42-30 | |
| » Starters: Ted Bowsfield vs Hal Brown | Second | 3½ out |
| Friday, July 1 |
| » Defeated White Sox (37-32), 4-0 | Memorial Stadium (20-18) | 43-30 | Won 2 |
| » Starters: Billy Pierce vs Milt Pappas | Second | 4 out |
| Saturday, July 2 |
| » Lost to White Sox (38-32), 8-7 | Memorial Stadium (20-19) | 43-31 | |
| » Starters: Early Wynn vs Chuck Estrada | Second | 4 out |
| Sunday, July 3 |
| » Lost to White Sox (39-32), 2-1 | Memorial Stadium (20-20) | 43-32 | Lost 2 |
| » Starters: Herb Score vs Jack Fisher | Third | 3½ out |
| Monday, July 4 |
| » Lost to Red Sox (26-44), 10-7 | Fenway Park (3-1) | 43-33 | Lost 3 |
| » Starters: Steve Barber vs Bill Monbouquette | Third | 4 out |
| » Defeated Red Sox (26-45), 8-6 | Fenway Park (4-1) | 44-33 | |
| » Starters: Jerry Walker vs Tom Borland | Third | 4 out |
| Tuesday, July 5 |
| » Defeated Red Sox (26-46), 9-4 | Fenway Park (5-1) | 45-33 | Won 2 |
| » Starters: Chuck Estrada vs Tom Brewer | Third | 4 out |
| Wednesday, July 6 |
| » Lost to Yankees (44-27), 5-2 | Memorial Stadium (20-21) | 45-34 | |
| » Starters: Whitey Ford vs Hal Brown | Third | 4 out |
| Thursday, July 7 |
| » Lost to Yankees (45-27), 6-3 | Memorial Stadium (20-22) | 45-35 | Lost 2 |
| » Starters: Bob Turley vs Milt Pappas | Third | 4 out |
| Friday, July 8 |
| » Lost to Senators (35-39), 9-5 | Memorial Stadium (20-23) | 45-36 | Lost 3 |
| » Starters: Pedro Ramos vs Jack Fisher | Third | 4 out |
| Saturday, July 9 |
| » Lost to Senators (36-39), 7-2 | Memorial Stadium (20-24) | 45-37 | Lost 4 |
| » Starters: Hal Woodeshick vs Hoyt Wilhelm | Fourth | 4 out |
| Sunday, July 10 |
| » Lost to Senators (37-39), 2-1 | Memorial Stadium (20-25) | 45-38 | Lost 5 |
| » Starters: Jack Kralick vs Jerry Walker | Fourth | 4 out |
| Friday, July 15 |
| » Defeated White Sox (44-36), 5-2 | Comiskey Park I (4-2) | 46-38 | |
| » Starters: Milt Pappas vs Billy Pierce | Fourth | 4 out |
| Saturday, July 16 |
| » Defeated White Sox (44-37), 4-3 | Comiskey Park I (5-2) | 47-38 | Won 2 |
| » Starters: Jerry Walker vs Frank Baumann | Third | 4 out |
| Sunday, July 17 |
| » Lost to White Sox (45-37), 2-1 | Comiskey Park I (5-3) | 47-39 | |
| » Starters: Steve Barber vs Bob Shaw | Fourth | 4 out |
| » Lost to White Sox (46-37), 14-2 | Comiskey Park I (5-4) | 47-40 | Lost 2 |
| » Starters: Jack Fisher vs Early Wynn | Fourth | 4 out |
| Monday, July 18 |
| » Lost to Athletics (30-51), 5-1 | Municipal Stadium (5-3) | 47-41 | Lost 3 |
| » Starters: Hal Brown vs Ned Garver | Fourth | 4 out |
| Tuesday, July 19 |
| » Defeated Athletics (30-52), 9-3 | Municipal Stadium (6-3) | 48-41 | |
| » Starters: Chuck Estrada vs Bud Daley | Fourth | 4 out |
| Wednesday, July 20 |
| » Lost to Athletics (31-52), 4-3 | Municipal Stadium (6-4) | 48-42 | |
| » Starters: Milt Pappas vs Ray Herbert | Fourth | 4 out |
| Friday, July 22 |
| » Defeated Tigers (41-43), 2-1 | Memorial Stadium (21-25) | 49-42 | |
| » Starters: Pete Burnside vs Steve Barber | Fourth | 4 out |
| Saturday, July 23 |
| » Lost to Tigers (42-43), 4-1 | Memorial Stadium (21-26) | 49-43 | |
| » Starters: Hank Aguirre vs Jerry Walker | Fourth | 3½ out |
| » Defeated Tigers (42-44), 4-3 | Memorial Stadium (22-26) | 50-43 | |
| » Starters: Phil Regan vs Hal Brown | Fourth | 3½ out |
| Sunday, July 24 |
| » Defeated Tigers (42-45), 2-1 | Memorial Stadium (23-26) | 51-43 | Won 2 |
| » Starters: Jim Bunning vs Chuck Estrada | Third | 3 out |
| Tuesday, July 26 |
| » Lost to Athletics (34-54), 2-1 | Memorial Stadium (23-27) | 51-44 | |
| » Starters: Johnny Kucks vs Milt Pappas | Third | 4 out |
| Thursday, July 28 |
| » Defeated Athletics (34-55), 5-0 | Memorial Stadium (24-27) | 52-44 | |
| » Starters: Bud Daley vs Steve Barber | Third | 3½ out |
| Friday, July 29 |
| » Lost to Indians (48-43), 3-1 | Memorial Stadium (24-28) | 52-45 | |
| » Starters: Jack Harshman vs Jack Fisher | Third | 3½ out |
| Saturday, July 30 |
| » Defeated Indians (48-44), 4-3 | Memorial Stadium (25-28) | 53-45 | |
| » Starters: Mudcat Grant vs Chuck Estrada | Third | 3½ out |
| Sunday, July 31 |
| » Defeated Indians (48-45), 6-5 | Memorial Stadium (26-28) | 54-45 | Won 2 |
| » Starters: Gary Bell vs Hal Brown | Third | 4 out |
| Monday, August 1 |
| » Defeated White Sox (57-41), 2-1 | Memorial Stadium (27-28) | 55-45 | Won 3 |
| » Starters: Herb Score vs Milt Pappas | Third | 3 out |
| Tuesday, August 2 |
| » Defeated White Sox (57-42), 6-2 | Memorial Stadium (28-28) | 56-45 | Won 4 |
| » Starters: Billy Pierce vs Steve Barber | Third | 3 out |
| Wednesday, August 3 |
| » Defeated White Sox (57-43), 6-5 | Memorial Stadium (29-28) | 57-45 | Won 5 |
| » Starters: Frank Baumann vs Hoyt Wilhelm | Third | 3 out |
| Friday, August 5 |
| » Lost to Indians (51-46), 4-3 | Cleveland Stadium (4-2) | 57-46 | |
| » Starters: Chuck Estrada vs Jim Perry | Third | 3 out |
| Saturday, August 6 |
| » Defeated Indians (51-47), 5-2 | Cleveland Stadium (5-2) | 58-46 | |
| » Starters: Jack Fisher vs Jack Harshman | Third | 3 out |
| Sunday, August 7 |
| » Defeated Indians (51-48), 8-6 | Cleveland Stadium (6-2) | 59-46 | Won 2 |
| » Starters: Steve Barber vs Mudcat Grant | Third | 3 out |
| » Defeated Indians (51-49), 9-2 | Cleveland Stadium (7-2) | 60-46 | Won 3 |
| » Starters: Milt Pappas vs Dick Stigman | Third | 3 out |
| Tuesday, August 9 |
| » Defeated Tigers (46-56), 3-0 | Tiger Stadium (5-2) | 61-46 | Won 4 |
| » Starters: Chuck Estrada vs Frank Lary | Second | 2½ out |
| Wednesday, August 10 |
| » Defeated Tigers (46-57), 4-2 | Tiger Stadium (6-2) | 62-46 | Won 5 |
| » Starters: Jerry Walker vs Pete Burnside | Second | 2½ out |
| Thursday, August 11 |
| » Defeated Tigers (46-58), 6-1 | Tiger Stadium (7-2) | 63-46 | Won 6 |
| » Starters: Jack Fisher vs Don Mossi | Second | 3 out |
| Friday, August 12 |
| » Defeated Red Sox (46-60), 4-3 | Memorial Stadium (30-28) | 64-46 | Won 7 |
| » Starters: Billy Muffett vs Steve Barber | Second | 3 out |
| Saturday, August 13 |
| » Defeated Red Sox (46-61), 8-7 | Memorial Stadium (31-28) | 65-46 | Won 8 |
| » Starters: Tom Brewer vs Milt Pappas | Second | 3 out |
| Sunday, August 14 |
| » Lost to Red Sox (47-61), 3-2 | Memorial Stadium (31-29) | 65-47 | |
| » Starters: Bill Monbouquette vs Steve Barber | First | -- |
| Monday, August 15 |
| » Lost to Yankees (63-45), 4-3 | Yankee Stadium (1-5) | 65-48 | Lost 2 |
| » Starters: Jerry Walker vs Art Ditmar | Second | 2½ out |
| Tuesday, August 16 |
| » Lost to Yankees (64-45), 1-0 | Yankee Stadium (1-6) | 65-49 | Lost 3 |
| » Starters: Chuck Estrada vs Whitey Ford | Third | 2½ out |
| Wednesday, August 17 |
| » Lost to Senators (57-57), 11-7 | Memorial Stadium (31-30) | 65-50 | Lost 4 |
| » Starters: Don Lee vs Jack Fisher | Third | 2½ out |
| Thursday, August 18 |
| » Defeated Senators (57-58), 10-8 | Memorial Stadium (32-30) | 66-50 | |
| » Starters: Jack Kralick vs Milt Pappas | Second | 2½ out |
| Saturday, August 20 |
| » Lost to Red Sox (49-64), 8-6 | Fenway Park (5-2) | 66-51 | |
| » Starters: Chuck Estrada vs Bill Monbouquette | Third | 2½ out |
| » Defeated Red Sox (49-65), 6-0 | Fenway Park (6-2) | 67-51 | |
| » Starters: Hal Brown vs Earl Wilson | Third | 2½ out |
| Sunday, August 21 |
| » Defeated Red Sox (49-66), 10-4 | Fenway Park (7-2) | 68-51 | Won 2 |
| » Starters: Steve Barber vs Ike Delock | Second | 2½ out |
| Tuesday, August 23 |
| » Lost to Tigers (57-60), 5-3 | Memorial Stadium (32-31) | 68-52 | |
| » Starters: Phil Regan vs Milt Pappas | Third | 2½ out |
| Wednesday, August 24 |
| » Defeated Tigers (57-61), 9-2 | Memorial Stadium (33-31) | 69-52 | |
| » Starters: Bob Bruce vs Jack Fisher | Second | 2½ out |
| Future Oriole Cal Ripken, Jr. is born in Havre De Grace, MD. |
| Thursday, August 25 |
| » Defeated Tigers (57-62), 9-3 | Memorial Stadium (34-31) | 70-52 | Won 2 |
| » Starters: Frank Lary vs Chuck Estrada | Second | 3 out |
| Friday, August 26 |
| » Defeated Athletics (43-76), 2-1 | Memorial Stadium (35-31) | 71-52 | Won 3 |
| » Starters: Ned Garver vs Steve Barber | Second | 3 out |
| » Defeated Athletics (43-77), 11-3 | Memorial Stadium (36-31) | 72-52 | Won 4 |
| » Starters: Bud Daley vs Hal Brown | Second | 3 out |
| Saturday, August 27 |
| » Lost to Athletics (44-77), 5-3 | Memorial Stadium (36-32) | 72-53 | |
| » Starters: Ray Herbert vs Jerry Walker | Third | 2½ out |
| Sunday, August 28 |
| » Defeated White Sox (71-53), 3-1 | Memorial Stadium (37-32) | 73-53 | |
| » Starters: Early Wynn vs Milt Pappas | Second | 2 out |
| Monday, August 29 |
| » Defeated White Sox (71-54), 4-0 | Memorial Stadium (38-32) | 74-53 | Won 2 |
| » Starters: Herb Score vs Jack Fisher | Second | 2½ out |
| Tuesday, August 30 |
| » Defeated Indians (60-64), 4-1 | Memorial Stadium (39-32) | 75-53 | Won 3 |
| » Starters: Jim Perry vs Chuck Estrada | Second | 2½ out |
| Wednesday, August 31 |
| » Defeated Indians (60-65), 6-3 | Memorial Stadium (40-32) | 76-53 | Won 4 |
| » Starters: Dick Stigman vs Steve Barber | Second | 2 out |
| Friday, September 2 |
| » Defeated Yankees (75-51), 5-0 | Memorial Stadium (41-32) | 77-53 | Won 5 |
| » Starters: Whitey Ford vs Milt Pappas | Second | 2 out |
| Future Oriole Rex Hudler is born in Tempe, AZ. |
| Saturday, September 3 |
| » Defeated Yankees (75-52), 2-0 | Memorial Stadium (42-32) | 78-53 | Won 6 |
| » Starters: Art Ditmar vs Jack Fisher | First | -- |
| Future Oriole Rene Gonzales is born in Austin, TX. |
| Sunday, September 4 |
| » Defeated Yankees (75-53), 6-2 | Memorial Stadium (43-32) | 79-53 | Won 7 |
| » Starters: Bill Stafford vs Chuck Estrada | First | -- |
| Monday, September 5 |
| » Lost to Senators (67-65), 4-0 | Griffith Stadium (3-2) | 79-54 | |
| » Starters: Steve Barber vs Chuck Stobbs | First | -- |
| » Defeated Senators (67-66), 3-1 | Griffith Stadium (4-2) | 80-54 | |
| » Starters: Hal Brown vs Pedro Ramos | First | -- |
| Wednesday, September 7 |
| » Lost to Indians (67-66), 3-2 | Cleveland Stadium (7-3) | 80-55 | |
| » Starters: Milt Pappas vs Jim Perry | First | -- |
| Future Oriole Wade Rowdon is born in Riverhead, NY. |
| Thursday, September 8 |
| » Defeated Indians (67-67), 9-0 | Cleveland Stadium (8-3) | 81-55 | |
| » Starters: Jack Fisher vs Dick Stigman | First | -- |
| Friday, September 9 |
| » Lost to White Sox (77-59), 5-2 | Comiskey Park I (5-5) | 81-56 | |
| » Starters: Chuck Estrada vs Bob Shaw | First | -- |
| Saturday, September 10 |
| » Lost to White Sox (78-59), 3-2 | Comiskey Park I (5-6) | 81-57 | Lost 2 |
| » Starters: Hal Brown vs Herb Score | Second | 1½ out |
| Sunday, September 11 |
| » Defeated Athletics (48-90), 4-0 | Municipal Stadium (7-4) | 82-57 | |
| » Starters: Steve Barber vs Ned Garver | Second | 1 out |
| Tuesday, September 13 |
| » Lost to Tigers (64-76), 3-1 | Tiger Stadium (7-3) | 82-58 | |
| » Starters: Milt Pappas vs Jim Bunning | Second | 1 out |
| » Major-league debuts: Ray Barker (Orioles) |
| Wednesday, September 14 |
| » Defeated Tigers (64-77), 11-10 | Tiger Stadium (8-3) | 83-58 | |
| » Starters: Jack Fisher vs Bob Bruce | Second | 1 out |
| Friday, September 16 |
| » Lost to Yankees (83-57), 4-2 | Yankee Stadium (1-7) | 83-59 | |
| » Starters: Steve Barber vs Whitey Ford | Second | 1 out |
| Future Oriole Mickey Tettleton is born in Oklahoma City, OK. |
| Saturday, September 17 |
| » Lost to Yankees (84-57), 5-3 | Yankee Stadium (1-8) | 83-60 | Lost 2 |
| » Starters: Chuck Estrada vs Bob Turley | Second | 2 out |
| Sunday, September 18 |
| » Lost to Yankees (85-57), 7-3 | Yankee Stadium (1-9) | 83-61 | Lost 3 |
| » Starters: Jack Fisher vs Art Ditmar | Second | 4 out |
| » Lost to Yankees (86-57), 2-0 | Yankee Stadium (1-10) | 83-62 | Lost 4 |
| » Starters: Milt Pappas vs Ralph Terry | Second | 4 out |
| Tuesday, September 20 |
| » Defeated Red Sox (63-82), 4-3 | Memorial Stadium (44-32) | 84-62 | |
| » Starters: Tom Brewer vs Hal Brown | Second | 4 out |
| Future Oriole Dave Gallagher is born in Trenton, NJ. |
| Wednesday, September 21 |
| » Lost to Red Sox (64-82), 4-1 | Memorial Stadium (44-33) | 84-63 | |
| » Starters: Ike Delock vs Steve Barber | Third | 5 out |
| Thursday, September 22 |
| » Major-league debuts: Dick Bertell (Cubs) |
| Friday, September 23 |
| » Lost to Senators (73-74), 4-0 | Griffith Stadium (4-3) | 84-64 | Lost 2 |
| » Starters: Chuck Estrada vs Chuck Stobbs | Third | 6 out |
| Saturday, September 24 |
| » Defeated Senators (73-75), 10-9 | Griffith Stadium (5-3) | 85-64 | |
| » Starters: Jack Fisher vs Don Lee | Third | 6 out |
| Sunday, September 25 |
| » Defeated Senators (73-76), 3-1 | Griffith Stadium (6-3) | 86-64 | Won 2 |
| » Starters: Milt Pappas vs Jack Kralick | Second | 6 out |
| Tuesday, September 27 |
| » Defeated Red Sox (64-86), 17-3 | Fenway Park (8-2) | 87-64 | Won 3 |
| » Starters: Hal Brown vs Ike Delock | Second | 6½ out |
| » Major-league debuts: Arnie Earley (Red Sox) |
| Wednesday, September 28 |
| » Lost to Red Sox (65-86), 5-4 | Fenway Park (8-3) | 87-65 | |
| » Starters: Steve Barber vs Billy Muffett | Second | 7½ out |
| Saturday, October 1 |
| » Defeated Senators (73-80), 3-2 | Griffith Stadium (7-3) | 88-65 | |
| » Starters: Chuck Estrada vs Jack Kralick | Second | 8 out |
| Sunday, October 2 |
| » Defeated Senators (73-81), 2-1 | Griffith Stadium (8-3) | 89-65 | Won 2 |
| » Starters: Milt Pappas vs Pedro Ramos | Second | 8 out |
| Monday, October 17 |
| Future Oriole Ken Dixon is born in Monroe, VA. |
| Tuesday, November 1 |
| Future Oriole Fernando Valenzuela is born in Navojoa, Mexico. |
| Monday, November 21 |
| Future Oriole Mark Eichhorn is born in San Jose, CA. |
| Saturday, November 26 |
| Future Oriole Harold Reynolds is born in Eugene, OR. |
| Wednesday, December 21 |
| Future Oriole Roger McDowell is born in Cincinnati, OH. Future Oriole Andy Van Slyke is born in Utica, NY. |
| Sunday, December 25 |
| Future Oriole Tom O'Malley is born in Orange, NJ. |
| Monday, December 26 |
| Future Oriole |
