| Saturday, January 23 |
| Future Indian Reggie Ritter is born in Malvern, AR. |
| Tuesday, February 16 |
| Former Indian Stuffy McInnis dies in Ipswich, MA at the age of 70. |
| Thursday, March 3 |
| Future Indian Neal Heaton is born in South Ozone Park, NY. |
| Friday, March 4 |
| Future Indian Jeff Dedmon is born in Torrance, CA. |
| Sunday, March 6 |
| Future Indian Rick Behenna is born in Miami, FL. |
| Monday, March 7 |
| Future Indian Joe Carter is born in Oklahoma City, OK. |
| Monday, March 14 |
| Future Indian Jerry Willard is born in Oxnard, CA. |
| Friday, March 18 |
| Former Indian Dixie Howell dies in Hollywood, FL at the age of 41. |
| Sunday, March 20 |
| Future Indian Mike Young is born in Oakland, CA. |
| Wednesday, March 30 |
| Former Indian Joe Connolly dies in San Francisco, CA at the age of 64. |
| Sunday, April 17 |
| » Major-league debuts: Chris Cannizzaro (Cardinals) |
| Monday, April 18 |
| » Major-league debuts: Don Mincher (Senators) |
| Tuesday, April 19 |
| » Lost to Tigers (1-0), 4-2 | Cleveland Stadium (0-1) | 0-1 | |
| » Starters: Frank Lary vs Gary Bell | Third | 1 out |
| » Major-league debuts: Walt Bond (Indians) |
| Wednesday, April 20 |
| » Lost to Tigers (2-0), 6-4 | Cleveland Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Don Mossi vs Jim Perry | Seventh | 2 out |
| Friday, April 22 |
| » Lost to Athletics (1-2), 4-1 | Municipal Stadium (0-1) | 0-3 | Lost 3 |
| » Starters: Wynn Hawkins vs Ray Herbert | Eighth | 3 out |
| » Major-league debuts: Wynn Hawkins and Dick Stigman (Indians) |
| Saturday, April 23 |
| » Lost to Athletics (2-2), 6-5 | Municipal Stadium (0-2) | 0-4 | Lost 4 |
| » Starters: Barry Latman vs Dick Hall | Sixth | 4 out |
| Sunday, April 24 |
| » Defeated Athletics (2-3), 7-0 | Municipal Stadium (1-2) | 1-4 | |
| » Starters: Gary Bell vs Don Larsen | Sixth | 4 out |
| Tuesday, April 26 |
| » Defeated Tigers (5-1), 2-1 | Tiger Stadium (1-0) | 2-4 | Won 2 |
| » Starters: Wynn Hawkins vs Jim Bunning | Seventh | 3 out |
| Thursday, April 28 |
| » Lost to White Sox (4-4), 3-1 | Comiskey Park I (0-1) | 2-5 | |
| » Starters: Gary Bell vs Billy Pierce | Sixth | 2½ out |
| Friday, April 29 |
| » Defeated Athletics (5-5), 5-4 | Cleveland Stadium (1-2) | 3-5 | |
| » Starters: Don Larsen vs Jim Perry | Fifth | 1½ out |
| Saturday, April 30 |
| » Defeated Athletics (5-6), 2-1 | Cleveland Stadium (2-2) | 4-5 | Won 2 |
| » Starters: Bud Daley vs Barry Latman | Fifth | 1½ out |
| Sunday, May 1 |
| » Defeated Athletics (5-7), 6-4 | Cleveland Stadium (3-2) | 5-5 | Won 3 |
| » Starters: Ned Garver vs Wynn Hawkins | Second | 1 out |
| » Defeated Athletics (5-8), 3-1 | Cleveland Stadium (4-2) | 6-5 | Won 4 |
| » Starters: George Brunet vs Dick Stigman | Second | 1 out |
| Monday, May 2 |
| » Defeated Senators (5-7), 3-2 | Griffith Stadium (1-0) | 7-5 | Won 5 |
| » Starters: Gary Bell vs Pedro Ramos | First | -- |
| Tuesday, May 3 |
| » Lost to Senators (6-7), 7-6 | Griffith Stadium (1-1) | 7-6 | |
| » Starters: Jim Perry vs Jim Kaat | Third | 1 out |
| Wednesday, May 4 |
| » Lost to Senators (7-7), 7-6 | Griffith Stadium (1-2) | 7-7 | Lost 2 |
| » Starters: Barry Latman vs Don Lee | Fourth | 1½ out |
| Thursday, May 5 |
| » Defeated Orioles (9-8), 11-6 | Memorial Stadium (1-0) | 8-7 | |
| » Starters: Wynn Hawkins vs Milt Pappas | Third | 1 out |
| Friday, May 6 |
| » Lost to Orioles (10-8), 9-2 | Memorial Stadium (1-1) | 8-8 | |
| » Starters: Dick Stigman vs Hal Brown | Fifth | 2 out |
| Saturday, May 7 |
| » Defeated Orioles (10-9), 3-1 | Memorial Stadium (2-1) | 9-8 | |
| » Starters: Gary Bell vs Chuck Estrada | Fourth | 2 out |
| Tuesday, May 10 |
| » Defeated Yankees (10-7), 5-1 | Yankee Stadium (1-0) | 10-8 | Won 2 |
| » Starters: Jim Perry vs Bill Short | Fourth | 1½ out |
| Thursday, May 12 |
| » Defeated Yankees (10-8), 3-2 | Yankee Stadium (2-0) | 11-8 | Won 3 |
| » Starters: Gary Bell vs Ralph Terry | Third | ½ out |
| Friday, May 13 |
| » Lost to White Sox (13-8), 4-2 | Cleveland Stadium (4-3) | 11-9 | |
| » Starters: Billy Pierce vs Wynn Hawkins | Fourth | 1½ out |
| Saturday, May 14 |
| » Defeated White Sox (13-9), 10-9 | Cleveland Stadium (5-3) | 12-9 | |
| » Starters: Herb Score vs Barry Latman | Second | ½ out |
| Sunday, May 15 |
| » Lost to White Sox (14-9), 4-0 | Cleveland Stadium (5-4) | 12-10 | |
| » Starters: Early Wynn vs Jim Perry | Third | ½ out |
| » Defeated White Sox (14-10), 6-3 | Cleveland Stadium (6-4) | 13-10 | |
| » Starters: Dick Donovan vs Dick Stigman | Third | ½ out |
| Tuesday, May 17 |
| » Defeated Yankees (12-10), 7-6 | Cleveland Stadium (7-4) | 14-10 | Won 2 |
| » Starters: Bill Short vs Gary Bell | Second | ½ out |
| Wednesday, May 18 |
| » Lost to Yankees (13-10), 4-2 | Cleveland Stadium (7-5) | 14-11 | |
| » Starters: Ralph Terry vs Wynn Hawkins | Fourth | 1½ out |
| Friday, May 20 |
| » Defeated Red Sox (10-13), 2-0 | Cleveland Stadium (8-5) | 15-11 | |
| » Starters: Bill Monbouquette vs Mudcat Grant | Second | 1½ out |
| Saturday, May 21 |
| » Defeated Red Sox (10-14), 6-1 | Cleveland Stadium (9-5) | 16-11 | Won 2 |
| » Starters: Jerry Casale vs Jim Perry | Second | 1½ out |
| Sunday, May 22 |
| » Lost to Orioles (18-13), 7-6 | Cleveland Stadium (9-6) | 16-12 | |
| » Starters: Hal Brown vs Gary Bell | Third | 1 out |
| Tuesday, May 24 |
| » Defeated Senators (12-17), 7-2 | Cleveland Stadium (10-6) | 17-12 | |
| » Starters: Chuck Stobbs vs Mudcat Grant | Second | 1½ out |
| Wednesday, May 25 |
| » Defeated Senators (12-18), 1-0 | Cleveland Stadium (11-6) | 18-12 | Won 2 |
| » Starters: Bill Fischer vs Jim Perry | Second | 1½ out |
| Saturday, May 28 |
| » Lost to Tigers (16-14), 4-3 | Tiger Stadium (1-1) | 18-13 | |
| » Starters: Gary Bell vs Jim Bunning | Second | 2 out |
| Sunday, May 29 |
| » Lost to Tigers (17-14), 6-5 | Tiger Stadium (1-2) | 18-14 | Lost 2 |
| » Starters: Wynn Hawkins vs Don Mossi | Second | 2 out |
| » Defeated Tigers (17-15), 6-4 | Tiger Stadium (2-2) | 19-14 | |
| » Starters: Mudcat Grant vs Frank Lary | Second | 2 out |
| Monday, May 30 |
| » Defeated White Sox (20-17), 4-1 | Comiskey Park I (1-1) | 20-14 | Won 2 |
| » Starters: Jim Perry vs Early Wynn | Second | 2 out |
| » Defeated White Sox (20-18), 9-4 | Comiskey Park I (2-1) | 21-14 | Won 3 |
| » Starters: Barry Latman vs Bob Shaw | Second | 2 out |
| Tuesday, May 31 |
| » Lost to White Sox (21-18), 6-4 | Comiskey Park I (2-2) | 21-15 | |
| » Starters: Gary Bell vs Billy Pierce | Second | 2 out |
| Thursday, June 2 |
| » Defeated Athletics (18-23), 7-6 | Municipal Stadium (2-2) | 22-15 | |
| » Starters: Mudcat Grant vs Ray Herbert | Second | 2½ out |
| Friday, June 3 |
| » Defeated Tigers (18-20), 6-2 | Cleveland Stadium (12-6) | 23-15 | Won 2 |
| » Starters: Frank Lary vs Jim Perry | Second | 2½ out |
| Saturday, June 4 |
| » Lost to Tigers (19-20), 7-4 | Cleveland Stadium (12-7) | 23-16 | |
| » Starters: Paul Foytack vs Barry Latman | Second | 2½ out |
| Sunday, June 5 |
| » Lost to Tigers (20-20), 7-2 | Cleveland Stadium (12-8) | 23-17 | Lost 2 |
| » Starters: Jim Bunning vs Gary Bell | Second | 2 out |
| » Defeated Tigers (20-21), 9-0 | Cleveland Stadium (13-8) | 24-17 | |
| » Starters: Pete Burnside vs Bobby Locke | Second | 2 out |
| Tuesday, June 7 |
| » Defeated Red Sox (15-27), 12-3 | Fenway Park (1-0) | 25-17 | Won 2 |
| » Starters: Mudcat Grant vs Jerry Casale | Second | 2½ out |
| Wednesday, June 8 |
| » Defeated Red Sox (15-28), 8-7 | Fenway Park (2-0) | 26-17 | Won 3 |
| » Starters: Jim Perry vs Ike Delock | First | -- |
| » Defeated Red Sox (15-29), 5-2 | Fenway Park (3-0) | 27-17 | Won 4 |
| » Starters: Gary Bell vs Dave Hillman | First | -- |
| Thursday, June 9 |
| » Defeated Red Sox (15-30), 3-2 | Fenway Park (4-0) | 28-17 | Won 5 |
| » Starters: Wynn Hawkins vs Bill Monbouquette | First | -- |
| Friday, June 10 |
| » Lost to Yankees (26-21), 4-3 | Yankee Stadium (2-1) | 28-18 | |
| » Starters: Bobby Locke vs Art Ditmar | First | -- |
| Saturday, June 11 |
| » Lost to Yankees (27-21), 6-4 | Yankee Stadium (2-2) | 28-19 | Lost 2 |
| » Starters: Mudcat Grant vs Whitey Ford | Second | 2½ out |
| Tuesday, June 14 |
| » Lost to Orioles (32-23), 7-4 | Cleveland Stadium (13-9) | 28-20 | Lost 3 |
| » Starters: Milt Pappas vs Gary Bell | First | -- |
| Wednesday, June 15 |
| » Defeated Orioles (32-24), 10-2 | Cleveland Stadium (14-9) | 29-20 | |
| » Starters: Steve Barber vs Jim Perry | First | -- |
| » Lost to Orioles (33-24), 13-5 | Cleveland Stadium (14-10) | 29-21 | |
| » Starters: Hal Brown vs Bobby Locke | First | -- |
| Thursday, June 16 |
| » Lost to Orioles (34-24), 3-2 | Cleveland Stadium (14-11) | 29-22 | Lost 2 |
| » Starters: Jack Fisher vs Ted Bowsfield | Second | 3½ out |
| Friday, June 17 |
| » Lost to Red Sox (19-34), 3-1 | Cleveland Stadium (14-12) | 29-23 | Lost 3 |
| » Starters: Frank Sullivan vs Wynn Hawkins | Third | 3½ out |
| Saturday, June 18 |
| » Defeated Red Sox (19-35), 2-1 | Cleveland Stadium (15-12) | 30-23 | |
| » Starters: Ike Delock vs Dick Stigman | Third | 1 out |
| Sunday, June 19 |
| » Lost to Red Sox (20-35), 7-1 | Cleveland Stadium (15-13) | 30-24 | |
| » Starters: Bill Monbouquette vs Jim Perry | Third | 3 out |
| » Lost to Red Sox (21-35), 3-2 | Cleveland Stadium (15-14) | 30-25 | Lost 2 |
| » Starters: Tom Brewer vs Gary Bell | Third | 3 out |
| Tuesday, June 21 |
| » Defeated Senators (25-31), 5-4 | Cleveland Stadium (16-14) | 31-25 | |
| » Starters: Pedro Ramos vs Mudcat Grant | Third | 3 out |
| Wednesday, June 22 |
| » Defeated Senators (25-32), 1-0 | Cleveland Stadium (17-14) | 32-25 | Won 2 |
| » Starters: Bill Fischer vs Ted Bowsfield | Third | 3 out |
| Thursday, June 23 |
| » Defeated Senators (25-33), 7-6 | Cleveland Stadium (18-14) | 33-25 | Won 3 |
| » Starters: Chuck Stobbs vs Barry Latman | Third | 2 out |
| Friday, June 24 |
| » Lost to Yankees (36-23), 10-6 | Cleveland Stadium (18-15) | 33-26 | |
| » Starters: Jim Coates vs Jim Perry | Third | 3 out |
| Saturday, June 25 |
| » Defeated Yankees (36-24), 4-1 | Cleveland Stadium (19-15) | 34-26 | |
| » Starters: Ralph Terry vs Dick Stigman | Third | 2 out |
| Sunday, June 26 |
| » Lost to Yankees (37-24), 6-2 | Cleveland Stadium (19-16) | 34-27 | |
| » Starters: Whitey Ford vs Ted Bowsfield | Third | 3 out |
| » Defeated Yankees (37-25), 7-6 | Cleveland Stadium (20-16) | 35-27 | |
| » Starters: Art Ditmar vs Mudcat Grant | Third | 3 out |
| Tuesday, June 28 |
| » Defeated Orioles (41-29), 3-2 | Memorial Stadium (3-1) | 36-27 | Won 2 |
| » Starters: Gary Bell vs Steve Barber | Third | 2 out |
| Wednesday, June 29 |
| » Defeated Orioles (41-30), 5-3 | Memorial Stadium (4-1) | 37-27 | Won 3 |
| » Starters: Dick Stigman vs Jerry Walker | Second | 2 out |
| Thursday, June 30 |
| » Lost to Orioles (42-30), 9-1 | Memorial Stadium (4-2) | 37-28 | |
| » Starters: Ted Bowsfield vs Hal Brown | Third | 3 out |
| Saturday, July 2 |
| » Defeated Senators (30-36), 12-2 | Griffith Stadium (2-2) | 38-28 | |
| » Starters: Mudcat Grant vs Camilo Pascual | Third | 3 out |
| Sunday, July 3 |
| » Defeated Senators (30-37), 5-2 | Griffith Stadium (3-2) | 39-28 | Won 2 |
| » Starters: Jim Perry vs Bill Fischer | Second | 3 out |
| » Defeated Senators (30-38), 11-5 | Griffith Stadium (4-2) | 40-28 | Won 3 |
| » Starters: John Briggs vs Don Lee | Second | 3 out |
| Monday, July 4 |
| » Defeated Athletics (27-44), 4-0 | Cleveland Stadium (21-16) | 41-28 | Won 4 |
| » Starters: Ray Herbert vs Gary Bell | Second | 1½ out |
| » Defeated Athletics (27-45), 7-4 | Cleveland Stadium (22-16) | 42-28 | Won 5 |
| » Starters: Johnny Kucks vs Ted Bowsfield | Second | 1½ out |
| Wednesday, July 6 |
| » Lost to White Sox (40-34), 7-5 | Cleveland Stadium (22-17) | 42-29 | |
| » Starters: Early Wynn vs Dick Stigman | Second | 2 out |
| Thursday, July 7 |
| » Lost to White Sox (41-34), 9-3 | Cleveland Stadium (22-18) | 42-30 | Lost 2 |
| » Starters: Billy Pierce vs Jim Perry | Second | 3 out |
| Friday, July 8 |
| » Lost to White Sox (42-34), 4-1 | Comiskey Park I (2-3) | 42-31 | Lost 3 |
| » Starters: Gary Bell vs Frank Baumann | Second | 3 out |
| Former Indian Joe Krakauskas dies in Hamilton, ON at the age of 46. |
| Saturday, July 9 |
| » Lost to White Sox (43-34), 8-4 | Comiskey Park I (2-4) | 42-32 | Lost 4 |
| » Starters: Ted Bowsfield vs Herb Score | Second | 3 out |
| Sunday, July 10 |
| » Defeated White Sox (43-35), 6-2 | Comiskey Park I (3-4) | 43-32 | |
| » Starters: Jim Perry vs Early Wynn | Second | 2½ out |
| » Lost to White Sox (44-35), 6-4 | Comiskey Park I (3-5) | 43-33 | |
| » Starters: Dick Stigman vs Bob Shaw | Second | 2½ out |
| Friday, July 15 |
| » Defeated Senators (37-40), 4-0 | Cleveland Stadium (23-18) | 44-33 | |
| » Starters: Pedro Ramos vs Jim Perry | Second | 1½ out |
| Saturday, July 16 |
| » Defeated Senators (37-41), 9-4 | Cleveland Stadium (24-18) | 45-33 | Won 2 |
| » Starters: Hal Woodeshick vs Gary Bell | Second | 1½ out |
| Sunday, July 17 |
| » Lost to Senators (38-41), 3-2 | Cleveland Stadium (24-19) | 45-34 | |
| » Starters: Tex Clevenger vs Mudcat Grant | Second | 1½ out |
| » Lost to Senators (39-41), 5-3 | Cleveland Stadium (24-20) | 45-35 | Lost 2 |
| » Starters: Jack Kralick vs John Briggs | Second | 1½ out |
| Monday, July 18 |
| » Lost to Yankees (47-33), 9-2 | Cleveland Stadium (24-21) | 45-36 | Lost 3 |
| » Starters: Whitey Ford vs Dick Stigman | Third | 2½ out |
| Former Indian Terry Turner dies in Cleveland, OH at the age of 80. |
| Tuesday, July 19 |
| » Lost to Yankees (48-33), 13-11 | Cleveland Stadium (24-22) | 45-37 | Lost 4 |
| » Starters: Jim Coates vs Jim Perry | Third | 3½ out |
| Wednesday, July 20 |
| » Defeated Yankees (48-34), 8-6 | Cleveland Stadium (25-22) | 46-37 | |
| » Starters: Art Ditmar vs Gary Bell | Third | 2½ out |
| Friday, July 22 |
| » Lost to Red Sox (34-51), 6-4 | Fenway Park (4-1) | 46-38 | |
| » Starters: Mudcat Grant vs Ike Delock | Third | 2½ out |
| » Major-league debuts: Mike de la Hoz (Indians) |
| Saturday, July 23 |
| » Defeated Red Sox (34-52), 4-2 | Fenway Park (5-1) | 47-38 | |
| » Starters: Jim Perry vs Tom Brewer | Third | 2½ out |
| Sunday, July 24 |
| » Lost to Red Sox (35-52), 10-6 | Fenway Park (5-2) | 47-39 | |
| » Starters: Gary Bell vs Bill Monbouquette | Fourth | 3½ out |
| » Lost to Red Sox (36-52), 7-6 | Fenway Park (5-3) | 47-40 | Lost 2 |
| » Starters: Jack Harshman vs Frank Sullivan | Fourth | 3½ out |
| Future Indian Jeff Kaiser is born in Wyandotte, MI. |
| Tuesday, July 26 |
| » Lost to Yankees (50-37), 6-1 | Yankee Stadium (2-3) | 47-41 | Lost 3 |
| » Starters: Dick Stigman vs Art Ditmar | Fourth | 4½ out |
| Thursday, July 28 |
| » Lost to Yankees (51-37), 4-0 | Yankee Stadium (2-4) | 47-42 | Lost 4 |
| » Starters: Jim Perry vs Whitey Ford | Fourth | 5½ out |
| » Lost to Yankees (52-37), 9-2 | Yankee Stadium (2-5) | 47-43 | Lost 5 |
| » Starters: Barry Latman vs Bob Turley | Fourth | 5½ out |
| Former Indian Marty Kavanagh dies in Taylor, MI at the age of 70. |
| Friday, July 29 |
| » Defeated Orioles (52-45), 3-1 | Memorial Stadium (5-2) | 48-43 | |
| » Starters: Jack Harshman vs Jack Fisher | Fourth | 4½ out |
| Saturday, July 30 |
| » Lost to Orioles (53-45), 4-3 | Memorial Stadium (5-3) | 48-44 | |
| » Starters: Mudcat Grant vs Chuck Estrada | Fourth | 5½ out |
| Sunday, July 31 |
| » Lost to Orioles (54-45), 6-5 | Memorial Stadium (5-4) | 48-45 | Lost 2 |
| » Starters: Gary Bell vs Hal Brown | Fourth | 7 out |
| Monday, August 1 |
| » Defeated Senators (46-49), 3-0 | Griffith Stadium (5-2) | 49-45 | |
| » Starters: Jim Perry vs Hal Woodeshick | Fourth | 6 out |
| Tuesday, August 2 |
| » Lost to Senators (47-49), 9-0 | Griffith Stadium (5-3) | 49-46 | |
| » Starters: Don Newcombe vs Camilo Pascual | Fourth | 7 out |
| Wednesday, August 3 |
| » Defeated Senators (47-50), 7-4 | Griffith Stadium (6-3) | 50-46 | |
| » Manager: Jo-Jo White |
| » Starters: Mudcat Grant vs Jack Kralick | Fourth | 6 out |
| Thursday, August 4 |
| Future Indian Steve Davis is born in San Antonio, TX. |
| Friday, August 5 |
| » Defeated Orioles (57-46), 4-3 | Cleveland Stadium (26-22) | 51-46 | Won 2 |
| » Manager: Jimmy Dykes |
| » Starters: Chuck Estrada vs Jim Perry | Fourth | 6 out |
| Saturday, August 6 |
| » Lost to Orioles (58-46), 5-2 | Cleveland Stadium (26-23) | 51-47 | |
| » Starters: Jack Fisher vs Jack Harshman | Fourth | 7 out |
| Sunday, August 7 |
| » Lost to Orioles (59-46), 8-6 | Cleveland Stadium (26-24) | 51-48 | Lost 2 |
| » Starters: Steve Barber vs Mudcat Grant | Fourth | 8 out |
| » Lost to Orioles (60-46), 9-2 | Cleveland Stadium (26-25) | 51-49 | Lost 3 |
| » Starters: Milt Pappas vs Dick Stigman | Fourth | 8 out |
| Tuesday, August 9 |
| » Defeated Red Sox (44-59), 6-3 | Cleveland Stadium (27-25) | 52-49 | |
| » Starters: Bill Monbouquette vs Jim Perry | Third | 7½ out |
| Wednesday, August 10 |
| » Lost to Red Sox (45-59), 6-1 | Cleveland Stadium (27-26) | 52-50 | |
| » Starters: Earl Wilson vs Barry Latman | Fourth | 8½ out |
| Thursday, August 11 |
| » Lost to Red Sox (46-59), 5-2 | Cleveland Stadium (27-27) | 52-51 | Lost 2 |
| » Starters: Ike Delock vs Jack Harshman | Fourth | 9 out |
| Friday, August 12 |
| » Lost to Tigers (47-58), 6-4 | Cleveland Stadium (27-28) | 52-52 | Lost 3 |
| » Starters: Jim Bunning vs Mudcat Grant | Fourth | 9 out |
| Saturday, August 13 |
| » Defeated Tigers (47-59), 2-1 | Cleveland Stadium (28-28) | 53-52 | |
| » Starters: Frank Lary vs Jim Perry | Fourth | 9 out |
| Sunday, August 14 |
| » Lost to Tigers (48-59), 6-1 | Cleveland Stadium (28-29) | 53-53 | |
| » Starters: Bill Fischer vs Dick Stigman | Third | 9½ out |
| » Lost to Tigers (49-59), 3-2 | Cleveland Stadium (28-30) | 53-54 | Lost 2 |
| » Starters: Paul Foytack vs Barry Latman | Third | 9½ out |
| Tuesday, August 16 |
| » Defeated Athletics (41-69), 4-3 | Cleveland Stadium (29-30) | 54-54 | |
| » Starters: Dick Hall vs Jack Harshman | Fourth | 9½ out |
| Wednesday, August 17 |
| » Defeated White Sox (66-49), 3-2 | Cleveland Stadium (30-30) | 55-54 | Won 2 |
| » Starters: Bob Shaw vs Jim Perry | Fourth | 9½ out |
| Thursday, August 18 |
| » Defeated White Sox (66-50), 8-6 | Cleveland Stadium (31-30) | 56-54 | Won 3 |
| » Starters: Billy Pierce vs Mudcat Grant | Third | 9½ out |
| Friday, August 19 |
| » Lost to Tigers (53-60), 5-3 | Tiger Stadium (2-3) | 56-55 | |
| » Starters: Bobby Locke vs Bill Fischer | Fourth | 9½ out |
| Saturday, August 20 |
| » Lost to Tigers (54-60), 4-2 | Tiger Stadium (2-4) | 56-56 | Lost 2 |
| » Starters: Barry Latman vs Bob Bruce | Fourth | 10½ out |
| Future Indian Mark Langston is born in San Diego, CA. Former Indian George Perring dies in Beloit, WI at the age of 77 |
| Sunday, August 21 |
| » Lost to Tigers (55-60), 6-4 | Tiger Stadium (2-5) | 56-57 | Lost 3 |
| » Starters: Jim Perry vs Jim Bunning | Fourth | 11 out |
| » Lost to Tigers (56-60), 6-4 | Tiger Stadium (2-6) | 56-58 | Lost 4 |
| » Starters: Gary Bell vs Frank Lary | Fourth | 11 out |
| Tuesday, August 23 |
| » Defeated Red Sox (49-67), 3-2 | Fenway Park (6-3) | 57-58 | |
| » Starters: Bobby Locke vs Billy Muffett | Fifth | 10 out |
| Wednesday, August 24 |
| » Defeated Red Sox (49-68), 3-1 | Fenway Park (7-3) | 58-58 | Won 2 |
| » Starters: Barry Latman vs Tom Brewer | Third | 10 out |
| Thursday, August 25 |
| » Lost to Red Sox (50-68), 10-7 | Fenway Park (7-4) | 58-59 | |
| » Starters: Don Newcombe vs Bill Monbouquette | Fifth | 10½ out |
| Friday, August 26 |
| » Lost to Yankees (69-48), 7-6 | Yankee Stadium (2-6) | 58-60 | Lost 2 |
| » Starters: Jim Perry vs Bob Turley | Fifth | 12½ out |
| » Lost to Yankees (70-48), 7-5 | Yankee Stadium (2-7) | 58-61 | Lost 3 |
| » Starters: Dick Stigman vs Whitey Ford | Fifth | 12½ out |
| Saturday, August 27 |
| » Lost to Yankees (71-48), 7-4 | Yankee Stadium (2-8) | 58-62 | Lost 4 |
| » Starters: Jack Harshman vs Bill Stafford | Fifth | 14½ out |
| » Lost to Yankees (72-48), 3-0 | Yankee Stadium (2-9) | 58-63 | Lost 5 |
| » Starters: Gary Bell vs Ralph Terry | Fifth | 14½ out |
| Sunday, August 28 |
| » Defeated Senators (63-61), 9-1 | Griffith Stadium (7-3) | 59-63 | |
| » Starters: Barry Latman vs Tex Clevenger | Fifth | 14 out |
| Monday, August 29 |
| » Defeated Senators (63-62), 6-4 | Griffith Stadium (8-3) | 60-63 | Won 2 |
| » Starters: Mudcat Grant vs Camilo Pascual | Fifth | 13½ out |
| Future Indian Reggie Williams is born in Memphis, TN. |
| Tuesday, August 30 |
| » Lost to Orioles (75-53), 4-1 | Memorial Stadium (5-5) | 60-64 | |
| » Starters: Jim Perry vs Chuck Estrada | Fifth | 14½ out |
| Wednesday, August 31 |
| » Lost to Orioles (76-53), 6-3 | Memorial Stadium (5-6) | 60-65 | Lost 2 |
| » Starters: Dick Stigman vs Steve Barber | Fifth | 15 out |
| Thursday, September 1 |
| » Defeated Athletics (45-83), 7-3 | Municipal Stadium (3-2) | 61-65 | |
| » Starters: Barry Latman vs Johnny Kucks | Fifth | 14½ out |
| Friday, September 2 |
| » Defeated Athletics (45-84), 6-2 | Municipal Stadium (4-2) | 62-65 | Won 2 |
| » Starters: Bobby Locke vs Dick Hall | Fifth | 13½ out |
| Saturday, September 3 |
| » Defeated Athletics (45-85), 6-5 | Municipal Stadium (5-2) | 63-65 | Won 3 |
| » Starters: Jim Perry vs Don Larsen | Fifth | 13½ out |
| » Major-league debuts: Frank Funk (Indians) |
| Future Indian Rene Gonzales is born in Austin, TX. |
| Sunday, September 4 |
| » Defeated Athletics (45-86), 10-2 | Municipal Stadium (6-2) | 64-65 | Won 4 |
| » Starters: Jack Harshman vs Bud Daley | Fifth | 13½ out |
| Monday, September 5 |
| » Lost to Tigers (61-70), 4-3 | Tiger Stadium (2-7) | 64-66 | |
| » Starters: Mudcat Grant vs Bill Fischer | Fifth | 13½ out |
| » Defeated Tigers (61-71), 4-2 | Tiger Stadium (3-7) | 65-66 | |
| » Starters: Barry Latman vs Paul Foytack | Fifth | 13½ out |
| Future Indian Candy Maldonado is born in Humacao, P.R. |
| Tuesday, September 6 |
| » Defeated Tigers (61-72), 10-8 | Tiger Stadium (4-7) | 66-66 | Won 2 |
| » Starters: Bobby Locke vs Pete Burnside | Fifth | 13 out |
| Wednesday, September 7 |
| » Defeated Orioles (80-55), 3-2 | Cleveland Stadium (32-30) | 67-66 | Won 3 |
| » Starters: Milt Pappas vs Jim Perry | Fifth | 12 out |
| Thursday, September 8 |
| » Lost to Orioles (81-55), 9-0 | Cleveland Stadium (32-31) | 67-67 | |
| » Starters: Jack Fisher vs Dick Stigman | Fifth | 13 out |
| Friday, September 9 |
| » Lost to Senators (70-66), 8-2 | Cleveland Stadium (32-32) | 67-68 | Lost 2 |
| » Starters: Pedro Ramos vs Mudcat Grant | Fifth | 13 out |
| Saturday, September 10 |
| » Defeated Senators (70-67), 5-4 | Cleveland Stadium (33-32) | 68-68 | |
| » Starters: Ted Sadowski vs Barry Latman | Fifth | 12½ out |
| Sunday, September 11 |
| » Lost to Yankees (81-55), 5-0 | Cleveland Stadium (33-33) | 68-69 | |
| » Starters: Ralph Terry vs Jim Perry | Fifth | 14½ out |
| » Lost to Yankees (82-55), 3-2 | Cleveland Stadium (33-34) | 68-70 | Lost 2 |
| » Starters: Jim Coates vs Bobby Locke | Fifth | 14½ out |
| Tuesday, September 13 |
| » Defeated Red Sox (61-79), 5-3 | Cleveland Stadium (34-34) | 69-70 | |
| » Starters: Tom Brewer vs Dick Stigman | Fifth | 13½ out |
| Wednesday, September 14 |
| » Defeated Red Sox (61-80), 11-7 | Cleveland Stadium (35-34) | 70-70 | Won 2 |
| » Starters: Frank Sullivan vs Barry Latman | Fifth | 12½ out |
| » Major-league debuts: Ty Cline (Indians) |
| Friday, September 16 |
| » Defeated Athletics (50-91), 4-2 | Cleveland Stadium (36-34) | 71-70 | Won 3 |
| » Starters: Ned Garver vs Jim Perry | Fifth | 12½ out |
| Future Indian Mel Hall is born in Lyons, NY. |
| Saturday, September 17 |
| » Lost to Athletics (51-91), 8-5 | Cleveland Stadium (36-35) | 71-71 | |
| » Starters: Dick Hall vs Jack Harshman | Fifth | 13½ out |
| Sunday, September 18 |
| » Lost to Athletics (52-91), 3-2 | Cleveland Stadium (36-36) | 71-72 | Lost 2 |
| » Starters: Ray Herbert vs Bobby Locke | Third | 14½ out |
| » Defeated Athletics (52-92), 9-2 | Cleveland Stadium (37-36) | 72-72 | |
| » Starters: Johnny Kucks vs Barry Latman | Third | 14½ out |
| Tuesday, September 20 |
| » Lost to Tigers (67-79), 9-1 | Cleveland Stadium (37-37) | 72-73 | |
| » Starters: Frank Lary vs Jim Perry | Fourth | 15½ out |
| Future Indian Dave Gallagher is born in Trenton, NJ. |
| Wednesday, September 21 |
| » Major-league debuts: Leo Posada (Athletics) |
| Future Indian Rick Rodriguez is born in Oakland, CA. |
| Thursday, September 22 |
| » Major-league debuts: Dick Bertell (Cubs) |
| Friday, September 23 |
| » Lost to White Sox (85-62), 7-0 | Cleveland Stadium (37-38) | 72-74 | Lost 2 |
| » Starters: Early Wynn vs Barry Latman | Fifth | 17 out |
| Saturday, September 24 |
| » Defeated White Sox (85-63), 6-5 | Cleveland Stadium (38-38) | 73-74 | |
| » Starters: Billy Pierce vs Jim Perry | Fourth | 17 out |
| Sunday, September 25 |
| » Defeated White Sox (85-64), 4-0 | Cleveland Stadium (39-38) | 74-74 | Won 2 |
| » Starters: Bob Shaw vs Bobby Locke | Fourth | 17 out |
| Monday, September 26 |
| » Lost to Athletics (55-94), 6-1 | Municipal Stadium (6-3) | 74-75 | |
| » Starters: Dick Stigman vs Bud Daley | Third | 18 out |
| Tuesday, September 27 |
| » Lost to Athletics (56-94), 5-4 | Municipal Stadium (6-4) | 74-76 | Lost 2 |
| » Starters: Barry Latman vs Ray Herbert | Fourth | 19 out |
| Wednesday, September 28 |
| » Lost to Athletics (57-94), 4-0 | Municipal Stadium (6-5) | 74-77 | Lost 3 |
| » Starters: Jim Perry vs Ned Garver | Fourth | 20 out |
| Friday, September |