| Sunday, January 17 |
| Future Giant Chili Davis is born in Kingston, Jamaica. |
| Monday, March 7 |
| Future Giant Joe Carter is born in Oklahoma City, OK. |
| Wednesday, March 30 |
| Former Giant Joe Connolly dies in San Francisco, CA at the age of 64. |
| Tuesday, April 12 |
| » Defeated Cardinals (0-1), 3-1 | Candlestick Park (1-0) | 1-0 | |
| » Starters: Larry Jackson vs Sam Jones | First | -- |
| Wednesday, April 13 |
| » Defeated Cardinals (0-2), 6-1 | Candlestick Park (2-0) | 2-0 | Won 2 |
| » Starters: Vinegar Bend Mizell vs Mike McCormick | First | -- |
| Thursday, April 14 |
| » Lost to Cubs (2-1), 6-5 | Candlestick Park (2-1) | 2-1 | |
| » Starters: Seth Morehead vs Jack Sanford | First | -- |
| Saturday, April 16 |
| » Defeated Cubs (2-2), 6-1 | Candlestick Park (3-1) | 3-1 | |
| » Starters: Dick Drott vs Sam Jones | First | -- |
| Sunday, April 17 |
| » Defeated Cubs (2-3), 4-3 | Candlestick Park (4-1) | 4-1 | Won 2 |
| » Starters: Bob Anderson vs Mike McCormick | First | -- |
| Tuesday, April 19 |
| » Lost to Dodgers (5-1), 4-0 | Candlestick Park (4-2) | 4-2 | |
| » Starters: Johnny Podres vs Billy O'Dell | Third | 1 out |
| Wednesday, April 20 |
| » Defeated Dodgers (5-2), 1-0 | Candlestick Park (5-2) | 5-2 | |
| » Starters: Don Drysdale vs Mike McCormick | First | -- |
| Future Giant Randy Kutcher is born in Anchorage, AK. |
| Friday, April 22 |
| » Defeated Cubs (2-5), 10-8 | Wrigley Field (1-0) | 6-2 | Won 2 |
| » Starters: Sam Jones vs Glen Hobbie | First | -- |
| Saturday, April 23 |
| » Defeated Cubs (2-6), 18-2 | Wrigley Field (2-0) | 7-2 | Won 3 |
| » Starters: Jack Sanford vs Dick Drott | First | -- |
| Sunday, April 24 |
| » Lost to Cubs (3-6), 9-4 | Wrigley Field (2-1) | 7-3 | |
| » Starters: Billy O'Dell vs Bob Anderson | Second | ½ out |
| Monday, April 25 |
| » Defeated Cardinals (4-6), 9-8 | Sportsman's Park III (1-0) | 8-3 | |
| » Starters: Mike McCormick vs Vinegar Bend Mizell | First | -- |
| Tuesday, April 26 |
| » Lost to Cardinals (5-6), 4-2 | Sportsman's Park III (1-1) | 8-4 | |
| » Starters: Sam Jones vs Larry Jackson | Second | ½ out |
| » Major-league debuts: Georges Maranda (Giants) |
| Thursday, April 28 |
| » Defeated Dodgers (7-6), 7-5 | Los Angeles Memorial Coliseum (1-0) | 9-4 | |
| » Starters: Jack Sanford vs Larry Sherry | Second | 1 out |
| Friday, April 29 |
| » Lost to Dodgers (8-6), 10-2 | Los Angeles Memorial Coliseum (1-1) | 9-5 | |
| » Starters: Sam Jones vs Johnny Podres | Second | 1½ out |
| Saturday, April 30 |
| » Defeated Dodgers (8-7), 6-3 | Los Angeles Memorial Coliseum (2-1) | 10-5 | |
| » Starters: Billy O'Dell vs Don Drysdale | Second | 1½ out |
| Monday, May 2 |
| » Defeated Braves (8-6), 5-0 | Candlestick Park (6-2) | 11-5 | Won 2 |
| » Starters: Carl Willey vs Mike McCormick | Second | 1 out |
| » Major-league debuts: Ken MacKenzie (Braves) |
| Wednesday, May 4 |
| » Lost to Reds (7-11), 3-2 | Candlestick Park (6-3) | 11-6 | |
| » Starters: Cal McLish vs Jack Sanford | Second | 1 out |
| Thursday, May 5 |
| » Lost to Reds (8-11), 4-3 | Candlestick Park (6-4) | 11-7 | Lost 2 |
| » Starters: Bob Purkey vs Johnny Antonelli | Second | 2 out |
| Friday, May 6 |
| » Defeated Pirates (13-6), 5-1 | Candlestick Park (7-4) | 12-7 | |
| » Starters: Vern Law vs Sam Jones | Second | 1 out |
| Saturday, May 7 |
| » Defeated Pirates (13-7), 6-5 | Candlestick Park (8-4) | 13-7 | Won 2 |
| » Starters: Harvey Haddix vs Jack Sanford | First | -- |
| Sunday, May 8 |
| » Defeated Pirates (13-8), 13-1 | Candlestick Park (9-4) | 14-7 | Won 3 |
| » Starters: Joe Gibbon vs Mike McCormick | First | -- |
| Tuesday, May 10 |
| » Defeated Phillies (9-14), 4-2 | Candlestick Park (10-4) | 15-7 | Won 4 |
| » Starters: Gene Conley vs Johnny Antonelli | First | -- |
| Wednesday, May 11 |
| » Defeated Phillies (9-15), 1-0 | Candlestick Park (11-4) | 16-7 | Won 5 |
| » Starters: Jim Owens vs Sam Jones | First | -- |
| Thursday, May 12 |
| » Defeated Phillies (9-16), 1-0 | Candlestick Park (12-4) | 17-7 | Won 6 |
| » Starters: Robin Roberts vs Jack Sanford | First | -- |
| Friday, May 13 |
| » Defeated Dodgers (11-15), 3-0 | Candlestick Park (13-4) | 18-7 | Won 7 |
| » Starters: Don Drysdale vs Mike McCormick | First | -- |
| Saturday, May 14 |
| » Lost to Dodgers (12-15), 2-1 | Candlestick Park (13-5) | 18-8 | |
| » Starters: Stan Williams vs Billy O'Dell | First | -- |
| Sunday, May 15 |
| » Defeated Dodgers (12-16), 2-0 | Candlestick Park (14-5) | 19-8 | |
| » Starters: Johnny Podres vs Johnny Antonelli | First | -- |
| Monday, May 16 |
| » Lost to Reds (15-13), 9-2 | Crosley Field (0-1) | 19-9 | |
| » Starters: Sam Jones vs Bob Purkey | First | -- |
| Tuesday, May 17 |
| » Defeated Reds (15-14), 9-3 | Crosley Field (1-1) | 20-9 | |
| » Starters: Jack Sanford vs Jim O'Toole | First | -- |
| Wednesday, May 18 |
| » Lost to Braves (13-11), 3-1 | County Stadium (0-1) | 20-10 | |
| » Starters: Mike McCormick vs Carl Willey | First | -- |
| Thursday, May 19 |
| » Major-league debuts: Ray Sadecki (Cardinals) |
| Friday, May 20 |
| » Lost to Pirates (22-10), 5-4 | Forbes Field (0-1) | 20-11 | Lost 2 |
| » Starters: Sam Jones vs Harvey Haddix | Second | 1½ out |
| Saturday, May 21 |
| » Defeated Pirates (22-11), 3-1 | Forbes Field (1-1) | 21-11 | |
| » Starters: Johnny Antonelli vs Bob Friend | Second | ½ out |
| Sunday, May 22 |
| » Lost to Pirates (23-11), 8-7 | Forbes Field (1-2) | 21-12 | |
| » Starters: Jack Sanford vs Vern Law | Second | 1½ out |
| Tuesday, May 24 |
| » Defeated Phillies (12-22), 4-0 | Shibe Park (1-0) | 22-12 | |
| » Starters: Sam Jones vs Jim Owens | First | -- |
| Wednesday, May 25 |
| » Defeated Phillies (12-23), 5-1 | Shibe Park (2-0) | 23-12 | Won 2 |
| » Starters: Mike McCormick vs Robin Roberts | First | -- |
| Thursday, May 26 |
| » Defeated Phillies (12-24), 9-0 | Shibe Park (3-0) | 24-12 | Won 3 |
| » Starters: Jack Sanford vs Gene Conley | First | -- |
| Friday, May 27 |
| » Lost to Cardinals (16-20), 5-4 | Sportsman's Park III (1-2) | 24-13 | |
| » Starters: Johnny Antonelli vs Ron Kline | First | -- |
| Saturday, May 28 |
| » Defeated Cardinals (16-21), 8-0 | Sportsman's Park III (2-2) | 25-13 | |
| » Starters: Billy O'Dell vs Ray Sadecki | First | -- |
| » Major-league debuts: Julian Javier (Cardinals) |
| Sunday, May 29 |
| » Lost to Cardinals (17-21), 4-1 | Sportsman's Park III (2-3) | 25-14 | |
| » Starters: Sam Jones vs Larry Jackson | First | -- |
| Monday, May 30 |
| » Lost to Cubs (13-20), 2-1 | Candlestick Park (14-6) | 25-15 | Lost 2 |
| » Starters: Bob Anderson vs Mike McCormick | Second | ½ out |
| » Defeated Cubs (13-21), 5-4 | Candlestick Park (15-6) | 26-15 | |
| » Starters: Dick Drott vs Jack Sanford | Second | ½ out |
| Tuesday, May 31 |
| » Lost to Cubs (14-21), 9-1 | Candlestick Park (15-7) | 26-16 | |
| » Starters: Glen Hobbie vs Johnny Antonelli | Second | 1½ out |
| Wednesday, June 1 |
| » Defeated Cubs (14-22), 2-1 | Candlestick Park (16-7) | 27-16 | |
| » Starters: Dick Ellsworth vs Sam Jones | Second | 1½ out |
| Thursday, June 2 |
| » Lost to Cardinals (20-22), 4-3 | Candlestick Park (16-8) | 27-17 | |
| » Starters: Larry Jackson vs Billy O'Dell | Second | 2 out |
| Friday, June 3 |
| » Defeated Cardinals (20-23), 3-2 | Candlestick Park (17-8) | 28-17 | |
| » Starters: Ernie Broglio vs Mike McCormick | Second | 2 out |
| Saturday, June 4 |
| » Defeated Cardinals (20-24), 2-0 | Candlestick Park (18-8) | 29-17 | Won 2 |
| » Starters: Ron Kline vs Jack Sanford | Second | 1½ out |
| Sunday, June 5 |
| » Lost to Cardinals (21-24), 9-4 | Candlestick Park (18-9) | 29-18 | |
| » Starters: Ray Sadecki vs Sam Jones | Second | 1 out |
| Tuesday, June 7 |
| » Lost to Reds (24-24), 5-1 | Candlestick Park (18-10) | 29-19 | Lost 2 |
| » Starters: Jay Hook vs Johnny Antonelli | Second | 1 out |
| Wednesday, June 8 |
| » Defeated Reds (24-25), 2-1 | Candlestick Park (19-10) | 30-19 | |
| » Starters: Jim O'Toole vs Mike McCormick | Second | 1 out |
| Thursday, June 9 |
| » Lost to Reds (25-25), 7-4 | Candlestick Park (19-11) | 30-20 | |
| » Starters: Joe Nuxhall vs Jack Sanford | Second | 2 out |
| Friday, June 10 |
| » Defeated Braves (23-19), 5-0 | Candlestick Park (20-11) | 31-20 | |
| » Starters: Warren Spahn vs Sam Jones | Second | 1 out |
| Saturday, June 11 |
| » Lost to Braves (24-19), 9-5 | Candlestick Park (20-12) | 31-21 | |
| » Starters: Juan Pizarro vs Johnny Antonelli | Second | 1 out |
| Sunday, June 12 |
| » Defeated Braves (24-20), 16-7 | Candlestick Park (21-12) | 32-21 | |
| » Starters: George Brunet vs Mike McCormick | Second | ½ out |
| Former Giant Art Wilson dies in Chicago, IL at the age of 75. |
| Monday, June 13 |
| » Lost to Braves (25-20), 12-5 | Candlestick Park (21-13) | 32-22 | |
| » Starters: Lew Burdette vs Jack Sanford | Second | 1 out |
| Tuesday, June 14 |
| » Lost to Pirates (33-20), 6-3 | Candlestick Park (21-14) | 32-23 | Lost 2 |
| » Starters: Bob Friend vs Sam Jones | Second | 2 out |
| Future Giant Mike Laga is born in Ridgewood, NJ. |
| Wednesday, June 15 |
| » Lost to Pirates (34-20), 14-6 | Candlestick Park (21-15) | 32-24 | Lost 3 |
| » Starters: Harvey Haddix vs Billy O'Dell | Second | 3 out |
| Thursday, June 16 |
| » Lost to Pirates (35-20), 10-7 | Candlestick Park (21-16) | 32-25 | Lost 4 |
| » Starters: Vinegar Bend Mizell vs Jack Sanford | Second | 4 out |
| Friday, June 17 |
| » Defeated Phillies (20-36), 7-3 | Candlestick Park (22-16) | 33-25 | |
| » Starters: Chris Short vs Mike McCormick | Second | 4 out |
| Saturday, June 18 |
| » Defeated Phillies (20-37), 7-4 | Candlestick Park (23-16) | 34-25 | Won 2 |
| » Manager: Tom Sheehan |
| » Starters: Dallas Green vs Sam Jones | Second | 4 out |
| » Major-league debuts: Dallas Green (Phillies) |
| Sunday, June 19 |
| » Lost to Phillies (21-37), 2-1 | Candlestick Park (23-17) | 34-26 | |
| » Starters: Robin Roberts vs Billy O'Dell | Second | 4 out |
| Tuesday, June 21 |
| » Lost to Braves (32-23), 9-6 | County Stadium (0-2) | 34-27 | Lost 2 |
| » Starters: Mike McCormick vs George Brunet | Third | 5½ out |
| » Lost to Braves (33-23), 2-1 | County Stadium (0-3) | 34-28 | Lost 3 |
| » Starters: Jack Sanford vs Juan Pizarro | Third | 5½ out |
| Wednesday, June 22 |
| » Lost to Braves (34-23), 7-4 | County Stadium (0-4) | 34-29 | Lost 4 |
| » Starters: Johnny Antonelli vs Lew Burdette | Third | 6½ out |
| Thursday, June 23 |
| » Lost to Braves (35-23), 8-4 | County Stadium (0-5) | 34-30 | Lost 5 |
| » Starters: Sam Jones vs Warren Spahn | Third | 6½ out |
| Future Giant Jim Deshaies is born in Massena, NY. |
| Friday, June 24 |
| » Defeated Reds (30-33), 5-3 | Crosley Field (2-1) | 35-30 | |
| » Starters: Mike McCormick vs Jay Hook | Third | 6½ out |
| Saturday, June 25 |
| » Defeated Reds (30-34), 5-2 | Crosley Field (3-1) | 36-30 | Won 2 |
| » Starters: Billy O'Dell vs Cal McLish | Third | 6½ out |
| Former Giant Tommy Corcoran dies in Plainfield, CT at the age of 92. |
| Sunday, June 26 |
| » Lost to Reds (31-34), 10-4 | Crosley Field (3-2) | 36-31 | |
| » Starters: Jack Sanford vs Bob Purkey | Third | 6 out |
| Tuesday, June 28 |
| » Tied Pirates, 7-7 | Forbes Field (1-2) | 36-31 | |
| » Starters: Sam Jones vs Harvey Haddix | Third | 6 out |
| Thursday, June 30 |
| » Defeated Pirates (41-25), 11-0 | Forbes Field (2-2) | 37-31 | |
| » Starters: Jack Sanford vs Bob Friend | Third | 6 out |
| » Lost to Pirates (42-25), 11-6 | Forbes Field (2-3) | 37-32 | |
| » Starters: Mike McCormick vs Vinegar Bend Mizell | Third | 6 out |
| » Major-league debuts: Earl Francis (Pirates) |
| Saturday, July 2 |
| » Lost to Phillies (29-42), 3-2 | Shibe Park (3-1) | 37-33 | Lost 2 |
| » Starters: Billy O'Dell vs John Buzhardt | Third | 6½ out |
| Sunday, July 3 |
| » Defeated Phillies (29-43), 11-5 | Shibe Park (4-1) | 38-33 | |
| » Starters: Sam Jones vs Chris Short | Third | 5½ out |
| Monday, July 4 |
| » Defeated Cubs (28-42), 4-0 | Wrigley Field (3-1) | 39-33 | Won 2 |
| » Starters: Jack Sanford vs Dick Ellsworth | Third | 5 out |
| » Tied Cubs, 1-1 | Wrigley Field (3-1) | 39-33 | |
| » Starters: Johnny Antonelli vs Bob Anderson | Third | 5 out |
| Tuesday, July 5 |
| » Lost to Dodgers (37-37), 8-0 | Los Angeles Memorial Coliseum (2-2) | 39-34 | |
| » Starters: Mike McCormick vs Johnny Podres | Third | 6 out |
| Wednesday, July 6 |
| » Lost to Dodgers (38-37), 10-0 | Los Angeles Memorial Coliseum (2-3) | 39-35 | Lost 2 |
| » Starters: Billy O'Dell vs Stan Williams | Third | 7 out |
| Thursday, July 7 |
| » Lost to Cardinals (39-38), 7-3 | Candlestick Park (23-18) | 39-36 | Lost 3 |
| » Starters: Larry Jackson vs Sam Jones | Third | 8 out |
| Friday, July 8 |
| » Lost to Cardinals (40-38), 7-1 | Candlestick Park (23-19) | 39-37 | Lost 4 |
| » Starters: Ray Sadecki vs Jack Sanford | Fifth | 8½ out |
| Saturday, July 9 |
| » Lost to Cubs (30-45), 7-6 | Candlestick Park (23-20) | 39-38 | Lost 5 |
| » Starters: Dick Ellsworth vs Mike McCormick | Fifth | 8½ out |
| Sunday, July 10 |
| » Defeated Cubs (30-46), 5-3 | Candlestick Park (24-20) | 40-38 | |
| » Starters: Don Cardwell vs Billy O'Dell | Fourth | 8½ out |
| Friday, July 15 |
| » Lost to Dodgers (42-38), 5-3 | Candlestick Park (24-21) | 40-39 | |
| » Starters: Don Drysdale vs Sam Jones | Fifth | 8 out |
| Saturday, July 16 |
| » Lost to Dodgers (43-38), 6-1 | Candlestick Park (24-22) | 40-40 | Lost 2 |
| » Starters: Stan Williams vs Jack Sanford | Fifth | 9 out |
| Sunday, July 17 |
| » Defeated Dodgers (43-39), 5-4 | Candlestick Park (25-22) | 41-40 | |
| » Starters: Johnny Podres vs Mike McCormick | Fifth | 8½ out |
| Tuesday, July 19 |
| » Defeated Phillies (34-51), 2-0 | Candlestick Park (26-22) | 42-40 | Won 2 |
| » Starters: John Buzhardt vs Juan Marichal | Fifth | 7½ out |
| Wednesday, July 20 |
| » Defeated Phillies (34-52), 3-1 | Candlestick Park (27-22) | 43-40 | Won 3 |
| » Starters: Chris Short vs Sam Jones | Fifth | 6½ out |
| Thursday, July 21 |
| » Lost to Phillies (35-52), 3-0 | Candlestick Park (27-23) | 43-41 | |
| » Starters: Robin Roberts vs Jack Sanford | Fifth | 7½ out |
| Friday, July 22 |
| » Lost to Pirates (53-35), 4-1 | Candlestick Park (27-24) | 43-42 | Lost 2 |
| » Starters: Vinegar Bend Mizell vs Mike McCormick | Fifth | 8½ out |
| Saturday, July 23 |
| » Defeated Pirates (53-36), 3-1 | Candlestick Park (28-24) | 44-42 | |
| » Starters: Harvey Haddix vs Juan Marichal | Fifth | 7½ out |
| Sunday, July 24 |
| » Defeated Pirates (53-37), 6-3 | Candlestick Park (29-24) | 45-42 | Won 2 |
| » Starters: Tom Cheney vs Billy O'Dell | Fifth | 6½ out |
| Tuesday, July 26 |
| » Lost to Braves (53-36), 3-1 | Candlestick Park (29-25) | 45-43 | |
| » Starters: Carl Willey vs Sam Jones | Fifth | 8 out |
| Wednesday, July 27 |
| » Defeated Braves (53-37), 5-0 | Candlestick Park (30-25) | 46-43 | |
| » Starters: Lew Burdette vs Jack Sanford | Fifth | 8 out |
| Thursday, July 28 |
| » Defeated Braves (53-38), 3-2 | Candlestick Park (31-25) | 47-43 | Won 2 |
| » Starters: Warren Spahn vs Juan Marichal | Fifth | 7½ out |
| Friday, July 29 |
| » Defeated Reds (42-52), 2-1 | Candlestick Park (32-25) | 48-43 | Won 3 |
| » Starters: Jay Hook vs Mike McCormick | Fifth | 7½ out |
| Saturday, July 30 |
| » Defeated Reds (42-53), 2-1 | Candlestick Park (33-25) | 49-43 | Won 4 |
| » Starters: Cal McLish vs Billy O'Dell | Fifth | 6½ out |
| Sunday, July 31 |
| » Defeated Reds (42-54), 6-2 | Candlestick Park (34-25) | 50-43 | Won 5 |
| » Starters: Bob Purkey vs Sam Jones | Fifth | 5½ out |
| Former Giant Joe Klinger dies in Little Rock, AR at the age of 58. |
| Monday, August 1 |
| Future Giant Dave Anderson is born in Louisville, KY. |
| Tuesday, August 2 |
| » Lost to Phillies (39-59), 7-3 | Shibe Park (4-2) | 50-44 | |
| » Starters: Jack Sanford vs Dallas Green | Fifth | 7 out |
| » Lost to Phillies (40-59), 6-5 | Shibe Park (4-3) | 50-45 | Lost 2 |
| » Starters: Juan Marichal vs John Buzhardt | Fifth | 7 out |
| » Major-league debuts: Sherman Jones (Giants) |
| Wednesday, August 3 |
| » Lost to Phillies (41-59), 6-5 | Shibe Park (4-4) | 50-46 | Lost 3 |
| » Starters: Mike McCormick vs Art Mahaffey | Fifth | 7 out |
| Thursday, August 4 |
| » Defeated Phillies (41-60), 8-7 | Shibe Park (5-4) | 51-46 | |
| » Starters: Jack Sanford vs Gene Conley | Fifth | 7 out |
| Friday, August 5 |
| » Lost to Pirates (60-40), 1-0 | Forbes Field (2-4) | 51-47 | |
| » Starters: Sam Jones vs Vinegar Bend Mizell | Fifth | 8 out |
| Saturday, August 6 |
| » Lost to Pirates (61-40), 8-7 | Forbes Field (2-5) | 51-48 | Lost 2 |
| » Starters: Juan Marichal vs Vern Law | Fifth | 9 out |
| Sunday, August 7 |
| » Lost to Pirates (62-40), 4-1 | Forbes Field (2-6) | 51-49 | Lost 3 |
| » Starters: Jack Sanford vs Bob Friend | Fifth | 11 out |
| » Lost to Pirates (63-40), 7-5 | Forbes Field (2-7) | 51-50 | Lost 4 |
| » Starters: Billy O'Dell vs Harvey Haddix | Fifth | 11 out |
| Monday, August 8 |
| » Lost to Reds (46-59), 4-3 | Crosley Field (3-3) | 51-51 | Lost 5 |
| » Starters: Mike McCormick vs Claude Osteen | Fifth | 11½ out |
| Wednesday, August 10 |
| » Lost to Reds (47-59), 5-3 | Crosley Field (3-4) | 51-52 | Lost 6 |
| » Starters: Sam Jones vs Bob Purkey | Fourth | 13 out |
| Thursday, August 11 |
| » Defeated Braves (57-47), 8-7 | County Stadium (1-5) | 52-52 | |
| » Starters: Billy O'Dell vs Juan Pizarro | Fifth | 12 out |
| Friday, August 12 |
| » Lost to Braves (58-47), 4-2 | County Stadium (1-6) | 52-53 | |
| » Starters: Jack Sanford vs Warren Spahn | Fourth | 12 out |
| Saturday, August 13 |
| » Lost to Braves (59-47), 4-2 | County Stadium (1-7) | 52-54 | Lost 2 |
| » Starters: Mike McCormick vs Bob Buhl | Fifth | 13 out |
| Sunday, August 14 |
| » Lost to Braves (60-47), 3-0 | County Stadium (1-8) | 52-55 | Lost 3 |
| » Starters: Sam Jones vs Lew Burdette | Fifth | 14½ out |
| Monday, August 15 |
| » Defeated Cardinals (63-50), 5-3 | Sportsman's Park III (3-3) | 53-55 | |
| » Starters: Billy O'Dell vs Ernie Broglio | Fifth | 13½ out |
| Tuesday, August 16 |
| » Defeated Cardinals (63-51), 7-3 | Sportsman's Park III (4-3) | 54-55 | Won 2 |
| » Starters: Juan Marichal vs Bob Gibson | Fifth | 14 out |
| Wednesday, August 17 |
| » Defeated Cardinals (63-52), 6-5 | Sportsman's Park III (5-3) | 55-55 | Won 3 |
| » Starters: Jack Sanford vs Ray Sadecki | Fifth | 14 out |
| Friday, August 19 |
| » Defeated Cubs (43-69), 2-1 | Wrigley Field (4-1) | 56-55 | Won 4 |
| » Starters: Mike McCormick vs Dick Ellsworth | Fifth | 13½ out |
| Saturday, August 20 |
| » Lost to Cubs (44-69), 9-5 | Wrigley Field (4-2) | 56-56 | |
| » Starters: Sam Jones vs Moe Drabowsky | Fifth | 14½ out |
| Sunday, August 21 |
| » Lost to Cubs (45-69), 5-3 | Wrigley Field (4-3) | 56-57 | Lost 2 |
| » Starters: Billy O'Dell vs Glen Hobbie | Fifth | 14 out |
| » Defeated Cubs (45-70), 5-3 | Wrigley Field (5-3) | 57-57 | |
| » Starters: Georges Maranda vs Don Cardwell | Fifth | 14 out |
| Monday, August 22 |
| » Lost to Dodgers (63-52), 8-5 | Los Angeles Memorial Coliseum (2-4) | 57-58 | |
| » Starters: Stu Miller vs Don Drysdale | Fifth | 14½ out |
| Tuesday, August 23 |
| » Defeated Reds (54-67), 6-1 | Candlestick Park (35-25) | 58-58 | |
| » Starters: Bob Purkey vs Jack Sanford | Fifth | 14½ out |
| Wednesday, August 24 |
| » Lost to Reds (55-67), 3-2 | Candlestick Park (35-26) | 58-59 | |
| » Starters: Jim O'Toole vs Mike McCormick | Fifth | 15½ out |
| Thursday, August 25 |
| » Defeated Reds (55-68), 8-5 | Candlestick Park (36-26) | 59-59 | |
| » Starters: Claude Osteen vs Sam Jones | Fifth | 14½ out |
| Friday, August 26 |
| » Lost to Braves (68-51), 3-2 | Candlestick Park (36-27) | 59-60 | |
| » Starters: Warren Spahn vs Georges Maranda | Fifth | 14½ out |
| Saturday, August 27 |
| » Defeated Braves (68-52), 3-1 | Candlestick Park (37-27) | 60-60 | |
| » Starters: Lew Burdette vs Stu Miller | Fifth | 13½ out |
| Sunday, August 28 |
| » Defeated Braves (68-53), 15-2 | Candlestick Park (38-27) | 61-60 | Won 2 |
| » Starters: Bob Buhl vs Jack Sanford | Fifth | 12½ out |
| Monday, August 29 |
| » Lost to Phillies (48-77), 2-0 | Candlestick Park (38-28) | 61-61 | |
| » Starters: Art Mahaffey vs Mike McCormick | Fifth | 13½ out |
| Tuesday, August 30 |
| » Defeated Phillies (48-78), 2-1 | Candlestick Park (39-28) | 62-61 | |
| » Starters: Robin Roberts vs Sam Jones | Fifth | 13½ out |
| Future Giant Randy O'Neal is born in Ashland, KY. |
| Wednesday, August 31 |
| » Lost to Pirates (78-49), 7-4 | Candlestick Park (39-29) | 62-62 | |
| » Starters: Vinegar Bend Mizell vs Billy O'Dell | Fifth | 14½ out |
| Thursday, September 1 |
| » Lost to Pirates (79-49), 6-1 | Candlestick Park (39-30) | 62-63 | Lost 2 |
| » Starters: Harvey Haddix vs Georges Maranda | Fifth | 15½ out |
| Friday, September 2 |
| » Defeated Dodgers (68-58), 4-3 | Candlestick Park (40-30) | 63-63 | |
| » Starters: Johnny Podres vs Jack Sanford | Fifth | 15 out |
| Saturday, September 3 |
| » Defeated Dodgers (68-59), 1-0 | Candlestick Park (41-30) | 64-63 | Won 2 |
| » Starters: Sandy Koufax vs Mike McCormick | Fifth | 14 out |
| Sunday, September 4 |
| » Defeated Dodgers (68-60), 8-3 | Candlestick Park (42-30) | 65-63 | Won 3 |
| » Starters: Danny McDevitt vs Sam Jones | Fifth | 14 out |
| Monday, September 5 |
| » Defeated Dodgers (68-61), 12-8 | Los Angeles Memorial Coliseum (3-4) | 66-63 | Won 4 |
| » Starters: Billy O'Dell vs Stan Williams | Fourth | 14 out |
| » Lost to Dodgers (69-61), 4-3 | Los Angeles Memorial Coliseum (3-5) | 66-64 | |
| » Starters: Juan Marichal vs Roger Craig | Fourth | 14 out |
| Future Giant Candy Maldonado is born in Humacao, P.R. |
| Tuesday, September 6 |
| » Lost to Dodgers (70-61), 7-0 | Los Angeles Memorial Coliseum (3-6) | 66-65 | Lost 2 |
| » Starters: Georges Maranda vs Don Drysdale | Fifth | 15 out |
| Wednesday, September 7 |
| » Lost to Braves (75-58), 6-5 | County Stadium (1-9) | 66-66 | Lost 3 |
| » Starters: Jack Sanford vs George Brunet | Fifth | 15 out |
| Thursday, September 8 |
| » Lost to Braves (76-58), 9-4 | County Stadium (1-10) | 66-67 | Lost 4 |
| » Starters: Mike McCormick vs Warren Spahn | Fifth | 15½ out |
| Friday, September 9 |
| » Defeated Reds (61-76), 4-2 | Crosley Field (4-4) | 67-67 | |
| » Starters: Sam Jones vs Jim Maloney | Fifth | 16 out |
| » Lost to Reds (62-76), 3-2 | Crosley Field (4-5) | 67-68 | |
| » Starters: Billy O'Dell vs Bob Purkey | Fifth | 16 out |
| Sunday, September 11 |
| » Lost to Reds (63-76), 2-1 | Crosley Field (4-6) | 67-69 | Lost 2 |
| » Starters: Juan Marichal vs Jim O'Toole | Fifth | 16½ out |
| » Defeated Reds (63-77), 3-2 | Crosley Field (5-6) | 68-69 | |
| » Starters: Stu Miller vs Cal McLish | Fifth | 16½ out |
| Monday, September 12 |
| » Lost to Pirates (85-52), 6-1 | Forbes Field (2-8) | 68-70 | |
| » Starters: Jack Sanford vs Harvey Haddix | Fifth | 17½ out |
| Tuesday, September 13 |
| » Defeated Pirates (85-53), 6-3 | Forbes Field (3-8) | 69-70 | |
| » Starters: Mike McCormick vs Vinegar Bend Mizell | Fifth | 16½ out |
| Wednesday, September 14 |
| » Lost to Phillies (52-88), 5-1 | Shibe Park (5-5) | 69-71 | |
| » Starters: Billy O'Dell vs Robin Roberts | Fifth | 16½ out |
| Thursday, September 15 |
| » Defeated Phillies (52-89), 8-6 | Shibe Park (6-5) | 70-71 | |
| » Starters: Sam Jones vs Jim Owens | Fifth | 16½ out |
| Friday, September 16 |
| » Defeated Cardinals (79-60), 6-2 | Sportsman's Park III (6-3) | 71-71 | Won 2 |
| » Starters: Juan Marichal vs Curt Simmons | Fifth | 15½ out |
| » Major-league debuts: Ed Olivares and Bob Sadowski (Cardinals) |
| Future Giant Mel Hall is born in Lyons, NY. |
| Saturday, September 17 |
| » Lost to Cardinals (80-60), 4-1 | Sportsman's Park III (6-4) | 71-72 | |
| » Starters: Jack Sanford vs Larry Jackson | Fifth | 16 out |
| Sunday, September 18 |
| » Lost to Cardinals (81-60), 4-3 | Sportsman's Park III (6-5) | 71-73 | Lost 2 |
| » Starters: Mike McCormick vs Ernie Broglio | Fifth | 17½ out |
| Monday, September 19 |
| » Defeated Cubs (55-86), 11-4 | Wrigley Field (6-3) | 72-73 | |
| » Starters: Eddie Fisher vs Glen Hobbie | Fifth | 16½ out |
| » Defeated Cubs (55-87), 4-1 | Wrigley Field (7-3) | 73-73 | Won 2 |
| » Starters: Billy O'Dell vs Seth Morehead | Fifth | 16½ out |
| Tuesday, September 20 |
| » Defeated Cubs (55-88), 5-2 | Wrigley Field (8-3) | 74-73 | Won 3 |
| » Starters: Sam Jones vs Dick Ellsworth | Fifth | 17 out |
| Thursday, September 22 |
| » Major-league debuts: Dick Bertell (Cubs) |
| Sunday, September 25 |
| » Defeated Dodgers (78-69), 13-9 | Los Angeles Memorial Coliseum (4-6) | 75-73 | Won 4 |
| » Starters: Juan Marichal vs Stan Williams | Fifth | 16 out |
| » Major-league debuts: Doug Camilli (Dodgers) |
| Monday, September 26 |
| » Defeated Dodgers (78-70), 6-2 | Los Angeles Memorial Coliseum (5-6) | 76-73 | Won 5 |
| » Starters: Mike McCormick vs Don Drysdale | Fifth | 15½ out |
| » Major-league debuts: Matty Alou (Giants) |
| Tuesday, September 27 |
| » Lost to Cubs (58-92), 3-1 | Candlestick Park (42-31) | 76-74 | |
| » Starters: Don Cardwell vs Billy O'Dell | Fifth | 16½ out |
| Wednesday, September 28 |
| » Lost to Cubs (59-92), 6-3 | Candlestick Park (42-32) | 76-75 | Lost 2 |
| » Starters: Bob Anderson vs Jack Sanford | Fifth | 17 out |
| Thursday, September 29 |
| Future Giant Rob Deer is born in Orange, CA. |
| Friday, September 30 |
| » Defeated Cardinals (86-66), 2-1 | Candlestick Park (43-32) | 77-75 | |
| » Starters: Ray Sadecki vs Sam Jones | Fifth | 16 out |
| Saturday, October 1 |
| » Defeated Cardinals (86-67), 7-2 | Candlestick Park (44-32) | 78-75 | Won 2 |
| » Starters: Ernie Broglio vs Juan Marichal | Fifth | 16 out |
| Sunday, October 2 |
| » Defeated Cardinals (86-68), 8-2 | Candlestick Park (45-32) | 79-75 | Won 3 |
| » Starters: Mel Nelson vs Mike McCormick | Fifth | 16 out |
| » Major-league debuts: Doug Clemens (Cardinals) |
| Future Giant Ernest Riles is born in Cairo, GA. |
| Wednesday, October 19 |
| Future Giant Mark Davis is born in Livermore, CA. |
| Tuesday, October 25 |
| Future Giant Kelly Downs is born in Ogden, UT. |
| Friday, November 11 |
| Former Giant |
