| Tuesday, January 12 |
| Future Cardinal Tim Hulett is born in Springfield, IL. |
| Sunday, April 3 |
| Future Cardinal Tim Conroy is born in McKeesport, PA. |
| Tuesday, April 12 |
| » Lost to Giants (1-0), 3-1 | Candlestick Park (0-1) | 0-1 | |
| » Starters: Larry Jackson vs Sam Jones | Second | 1 out |
| Wednesday, April 13 |
| » Lost to Giants (2-0), 6-1 | Candlestick Park (0-2) | 0-2 | Lost 2 |
| » Starters: Vinegar Bend Mizell vs Mike McCormick | Fifth | 2 out |
| Thursday, April 14 |
| » Lost to Dodgers (2-1), 3-2 | Los Angeles Memorial Coliseum (0-1) | 0-3 | Lost 3 |
| » Starters: Ron Kline vs Johnny Podres | Third | 2 out |
| Saturday, April 16 |
| » Lost to Dodgers (3-1), 3-2 | Los Angeles Memorial Coliseum (0-2) | 0-4 | Lost 4 |
| » Starters: Larry Jackson vs Don Drysdale | Fifth | 3 out |
| Sunday, April 17 |
| » Lost to Dodgers (4-1), 7-5 | Los Angeles Memorial Coliseum (0-3) | 0-5 | Lost 5 |
| » Starters: Ernie Broglio vs Larry Sherry | Sixth | 4 out |
| » Major-league debuts: Chris Cannizzaro (Cardinals) |
| Tuesday, April 19 |
| » Defeated Cubs (2-4), 5-2 | Sportsman's Park III (1-0) | 1-5 | |
| » Starters: Seth Morehead vs Vinegar Bend Mizell | Seventh | 4 out |
| Friday, April 22 |
| » Defeated Dodgers (5-3), 11-7 | Sportsman's Park III (2-0) | 2-5 | Won 2 |
| » Starters: Sandy Koufax vs Larry Jackson | Sixth | 3½ out |
| » Major-league debuts: Ed Rakow (Dodgers) |
| Saturday, April 23 |
| » Defeated Dodgers (5-4), 9-5 | Sportsman's Park III (3-0) | 3-5 | Won 3 |
| » Starters: Danny McDevitt vs Ron Kline | Sixth | 3½ out |
| Sunday, April 24 |
| » Defeated Dodgers (5-5), 7-2 | Sportsman's Park III (4-0) | 4-5 | Won 4 |
| » Starters: Johnny Podres vs Bob Miller | Fifth | 3 out |
| Monday, April 25 |
| » Lost to Giants (8-3), 9-8 | Sportsman's Park III (4-1) | 4-6 | |
| » Starters: Mike McCormick vs Vinegar Bend Mizell | Fifth | 3½ out |
| Tuesday, April 26 |
| » Defeated Giants (8-4), 4-2 | Sportsman's Park III (5-1) | 5-6 | |
| » Starters: Sam Jones vs Larry Jackson | Fifth | 3 out |
| » Major-league debuts: Georges Maranda (Giants) |
| Friday, April 29 |
| » Defeated Cubs (3-9), 16-6 | Sportsman's Park III (6-1) | 6-6 | Won 2 |
| » Starters: Seth Morehead vs Bob Miller | Fifth | 3½ out |
| Saturday, April 30 |
| » Defeated Cubs (3-10), 5-4 | Sportsman's Park III (7-1) | 7-6 | Won 3 |
| » Starters: Bob Anderson vs Vinegar Bend Mizell | Fourth | 3½ out |
| Sunday, May 1 |
| » Lost to Cubs (4-10), 5-4 | Sportsman's Park III (7-2) | 7-7 | |
| » Starters: Glen Hobbie vs Larry Jackson | Fifth | 4½ out |
| Monday, May 2 |
| » Defeated Pirates (12-4), 4-3 | Sportsman's Park III (8-2) | 8-7 | |
| » Starters: Harvey Haddix vs Ron Kline | Fourth | 3½ out |
| Wednesday, May 4 |
| » Defeated Phillies (6-12), 5-3 | Sportsman's Park III (9-2) | 9-7 | Won 2 |
| » Starters: John Buzhardt vs Bob Gibson | Fourth | 2½ out |
| Thursday, May 5 |
| » Lost to Phillies (7-12), 3-1 | Sportsman's Park III (9-3) | 9-8 | |
| » Starters: Jim Owens vs Vinegar Bend Mizell | Fourth | 3½ out |
| Friday, May 6 |
| » Lost to Reds (9-11), 1-0 | Crosley Field (0-1) | 9-9 | Lost 2 |
| » Starters: Bob Miller vs Jim O'Toole | Fourth | 3½ out |
| Saturday, May 7 |
| » Lost to Reds (10-11), 6-2 | Crosley Field (0-2) | 9-10 | Lost 3 |
| » Starters: Ron Kline vs Jay Hook | Fourth | 3½ out |
| Sunday, May 8 |
| » Lost to Reds (11-11), 5-2 | Crosley Field (0-3) | 9-11 | Lost 4 |
| » Starters: Larry Jackson vs Cal McLish | Sixth | 4½ out |
| Wednesday, May 11 |
| » Lost to Braves (10-7), 12-8 | County Stadium (0-1) | 9-12 | Lost 5 |
| » Starters: Lindy McDaniel vs Warren Spahn | Sixth | 6 out |
| Thursday, May 12 |
| » Lost to Braves (11-7), 4-3 | County Stadium (0-2) | 9-13 | Lost 6 |
| » Starters: Vinegar Bend Mizell vs Bob Buhl | Sixth | 7 out |
| Friday, May 13 |
| » Lost to Cubs (7-13), 4-1 | Wrigley Field (0-1) | 9-14 | Lost 7 |
| » Starters: Ron Kline vs Glen Hobbie | Sixth | 8 out |
| Saturday, May 14 |
| » Lost to Cubs (8-13), 4-0 | Wrigley Field (0-2) | 9-15 | Lost 8 |
| » Starters: Frank Barnes vs Dick Ellsworth | Seventh | 8 out |
| Sunday, May 15 |
| » Defeated Cubs (8-14), 6-1 | Wrigley Field (1-2) | 10-15 | |
| » Starters: Larry Jackson vs Dick Drott | Seventh | 8½ out |
| » Lost to Cubs (9-14), 4-0 | Wrigley Field (1-3) | 10-16 | |
| » Starters: Lindy McDaniel vs Don Cardwell | Seventh | 8½ out |
| Monday, May 16 |
| » Defeated Phillies (11-19), 5-3 | Shibe Park (1-0) | 11-16 | |
| » Starters: Vinegar Bend Mizell vs Jim Owens | Sixth | 7½ out |
| Wednesday, May 18 |
| » Lost to Pirates (20-10), 4-2 | Forbes Field (0-1) | 11-17 | |
| » Starters: Ron Kline vs Vern Law | Fifth | 8 out |
| Thursday, May 19 |
| » Lost to Pirates (21-10), 8-3 | Forbes Field (0-2) | 11-18 | Lost 2 |
| » Starters: Ray Sadecki vs Joe Gibbon | Seventh | 9 out |
| » Major-league debuts: Ray Sadecki (Cardinals) |
| Friday, May 20 |
| » Defeated Reds (17-15), 6-1 | Sportsman's Park III (10-3) | 12-18 | |
| » Starters: Jim O'Toole vs Larry Jackson | Seventh | 9 out |
| Saturday, May 21 |
| » Defeated Reds (17-16), 6-5 | Sportsman's Park III (11-3) | 13-18 | Won 2 |
| » Starters: Bob Purkey vs Vinegar Bend Mizell | Fifth | 8 out |
| Sunday, May 22 |
| » Defeated Reds (17-17), 5-4 | Sportsman's Park III (12-3) | 14-18 | Won 3 |
| » Starters: Jay Hook vs Ron Kline | Fifth | 8½ out |
| » Lost to Reds (18-17), 5-3 | Sportsman's Park III (12-4) | 14-19 | |
| » Starters: Don Newcombe vs Marshall Bridges | Fifth | 8½ out |
| Wednesday, May 25 |
| » Defeated Braves (15-12), 5-3 | Sportsman's Park III (13-4) | 15-19 | |
| » Starters: Warren Spahn vs Larry Jackson | Sixth | 7½ out |
| Thursday, May 26 |
| » Lost to Braves (16-12), 4-1 | Sportsman's Park III (13-5) | 15-20 | |
| » Starters: Bob Buhl vs Vinegar Bend Mizell | Sixth | 8½ out |
| Future Cardinal Rob Murphy is born in Miami, FL. |
| Friday, May 27 |
| » Defeated Giants (24-13), 5-4 | Sportsman's Park III (14-5) | 16-20 | |
| » Starters: Johnny Antonelli vs Ron Kline | Sixth | 7½ out |
| Saturday, May 28 |
| » Lost to Giants (25-13), 8-0 | Sportsman's Park III (14-6) | 16-21 | |
| » Starters: Billy O'Dell vs Ray Sadecki | Sixth | 8½ out |
| » Major-league debuts: Julian Javier (Cardinals) |
| Sunday, May 29 |
| » Defeated Giants (25-14), 4-1 | Sportsman's Park III (15-6) | 17-21 | |
| » Starters: Sam Jones vs Larry Jackson | Fifth | 7½ out |
| Monday, May 30 |
| » Defeated Dodgers (19-21), 15-3 | Los Angeles Memorial Coliseum (1-3) | 18-21 | Won 2 |
| » Starters: Ernie Broglio vs Don Drysdale | Sixth | 7½ out |
| Tuesday, May 31 |
| » Lost to Dodgers (20-21), 8-3 | Los Angeles Memorial Coliseum (1-4) | 18-22 | |
| » Starters: Ron Kline vs Stan Williams | Sixth | 8½ out |
| Wednesday, June 1 |
| » Defeated Dodgers (20-22), 5-2 | Los Angeles Memorial Coliseum (2-4) | 19-22 | |
| » Starters: Ray Sadecki vs Sandy Koufax | Sixth | 8½ out |
| Thursday, June 2 |
| » Defeated Giants (27-17), 4-3 | Candlestick Park (1-2) | 20-22 | Won 2 |
| » Starters: Larry Jackson vs Billy O'Dell | Fifth | 8 out |
| Friday, June 3 |
| » Lost to Giants (28-17), 3-2 | Candlestick Park (1-3) | 20-23 | |
| » Starters: Ernie Broglio vs Mike McCormick | Fifth | 9 out |
| Saturday, June 4 |
| » Lost to Giants (29-17), 2-0 | Candlestick Park (1-4) | 20-24 | Lost 2 |
| » Starters: Ron Kline vs Jack Sanford | Sixth | 9½ out |
| Sunday, June 5 |
| » Defeated Giants (29-18), 9-4 | Candlestick Park (2-4) | 21-24 | |
| » Starters: Ray Sadecki vs Sam Jones | Fifth | 8 out |
| Monday, June 6 |
| » Defeated Phillies (16-31), 5-2 | Sportsman's Park III (16-6) | 22-24 | Won 2 |
| » Starters: Chris Short vs Larry Jackson | Fifth | 7½ out |
| Tuesday, June 7 |
| » Lost to Phillies (17-31), 5-3 | Sportsman's Park III (16-7) | 22-25 | |
| » Starters: Robin Roberts vs Bob Miller | Fifth | 7½ out |
| Wednesday, June 8 |
| » Lost to Phillies (18-31), 5-4 | Sportsman's Park III (16-8) | 22-26 | Lost 2 |
| » Starters: John Buzhardt vs Ron Kline | Fifth | 8½ out |
| Friday, June 10 |
| » Defeated Pirates (31-18), 9-6 | Sportsman's Park III (17-8) | 23-26 | |
| » Starters: Harvey Haddix vs Larry Jackson | Fifth | 8 out |
| Saturday, June 11 |
| » Defeated Pirates (31-19), 7-6 | Sportsman's Park III (18-8) | 24-26 | Won 2 |
| » Starters: Joe Gibbon vs Ray Sadecki | Fifth | 7 out |
| Sunday, June 12 |
| » Lost to Pirates (32-19), 15-3 | Sportsman's Park III (18-9) | 24-27 | |
| » Starters: Vern Law vs Ron Kline | Fifth | 7 out |
| » Defeated Pirates (32-20), 5-2 | Sportsman's Park III (19-9) | 25-27 | |
| » Starters: Vinegar Bend Mizell vs Ernie Broglio | Fifth | 7 out |
| Tuesday, June 14 |
| » Defeated Reds (26-28), 6-3 | Crosley Field (1-3) | 26-27 | Won 2 |
| » Starters: Larry Jackson vs Jim O'Toole | Fourth | 7 out |
| Future Cardinal Mike Laga is born in Ridgewood, NJ. |
| Wednesday, June 15 |
| » Defeated Reds (26-29), 6-0 | Crosley Field (2-3) | 27-27 | Won 3 |
| » Starters: Ray Sadecki vs Joe Nuxhall | Fourth | 7 out |
| Thursday, June 16 |
| » Defeated Reds (26-30), 6-5 | Crosley Field (3-3) | 28-27 | Won 4 |
| » Starters: Ernie Broglio vs Bob Purkey | Fourth | 7 out |
| Friday, June 17 |
| » Lost to Braves (28-22), 3-2 | County Stadium (0-3) | 28-28 | |
| » Starters: Ron Kline vs George Brunet | Fourth | 8 out |
| Saturday, June 18 |
| » Lost to Braves (29-22), 5-0 | County Stadium (0-4) | 28-29 | Lost 2 |
| » Starters: Larry Jackson vs Lew Burdette | Fourth | 9 out |
| Sunday, June 19 |
| » Defeated Braves (29-23), 4-3 | County Stadium (1-4) | 29-29 | |
| » Starters: Curt Simmons vs Warren Spahn | Fourth | 8½ out |
| » Lost to Braves (30-23), 3-2 | County Stadium (1-5) | 29-30 | |
| » Starters: Ray Sadecki vs Carl Willey | Fourth | 8½ out |
| Tuesday, June 21 |
| » Lost to Pirates (38-21), 3-2 | Forbes Field (0-3) | 29-31 | Lost 2 |
| » Starters: Bob Gibson vs Vern Law | Fifth | 9½ out |
| Wednesday, June 22 |
| » Lost to Pirates (39-21), 5-0 | Forbes Field (0-4) | 29-32 | Lost 3 |
| » Starters: Larry Jackson vs Bob Friend | Fifth | 10½ out |
| Thursday, June 23 |
| » Defeated Pirates (39-22), 3-1 | Forbes Field (1-4) | 30-32 | |
| » Starters: Ron Kline vs Harvey Haddix | Fourth | 9½ out |
| Friday, June 24 |
| » Lost to Phillies (26-37), 4-3 | Shibe Park (1-1) | 30-33 | |
| » Starters: Ray Sadecki vs Robin Roberts | Fourth | 10½ out |
| Saturday, June 25 |
| » Defeated Phillies (26-38), 1-0 | Shibe Park (2-1) | 31-33 | |
| » Starters: Curt Simmons vs Jim Owens | Fourth | 10½ out |
| Sunday, June 26 |
| » Lost to Phillies (27-38), 3-2 | Shibe Park (2-2) | 31-34 | |
| » Starters: Larry Jackson vs John Buzhardt | Fourth | 9½ out |
| » Defeated Phillies (27-39), 4-3 | Shibe Park (3-2) | 32-34 | |
| » Starters: Bob Gibson vs Chris Short | Fourth | 9½ out |
| Tuesday, June 28 |
| » Lost to Reds (32-34), 10-4 | Sportsman's Park III (19-10) | 32-35 | |
| » Starters: Jim O'Toole vs Ron Kline | Fifth | 10 out |
| Wednesday, June 29 |
| » Defeated Reds (32-35), 5-2 | Sportsman's Park III (20-10) | 33-35 | |
| » Starters: Jay Hook vs Ray Sadecki | Fourth | 9½ out |
| » Major-league debuts: Joe Gaines (Reds) |
| Thursday, June 30 |
| » Major-league debuts: Earl Francis (Pirates) |
| Friday, July 1 |
| » Defeated Braves (38-28), 8-7 | Sportsman's Park III (21-10) | 34-35 | Won 2 |
| » Starters: Don Nottebart vs Larry Jackson | Fourth | 9 out |
| » Defeated Braves (38-29), 7-5 | Sportsman's Park III (22-10) | 35-35 | Won 3 |
| » Starters: George Brunet vs Curt Simmons | Fourth | 9 out |
| » Major-league debuts: Don Nottebart (Braves) |
| Saturday, July 2 |
| » Defeated Braves (38-30), 7-1 | Sportsman's Park III (23-10) | 36-35 | Won 4 |
| » Starters: Warren Spahn vs Bob Gibson | Fourth | 8 out |
| Sunday, July 3 |
| » Lost to Braves (39-30), 4-3 | Sportsman's Park III (23-11) | 36-36 | |
| » Starters: Bob Buhl vs Ron Kline | Fourth | 8 out |
| Monday, July 4 |
| » Defeated Dodgers (35-37), 6-2 | Sportsman's Park III (24-11) | 37-36 | |
| » Starters: Sandy Koufax vs Ernie Broglio | Fourth | 8 out |
| » Lost to Dodgers (36-37), 5-4 | Sportsman's Park III (24-12) | 37-37 | |
| » Starters: Roger Craig vs Ray Sadecki | Fourth | 8 out |
| Tuesday, July 5 |
| » Defeated Cubs (28-43), 3-2 | Wrigley Field (2-3) | 38-37 | |
| » Starters: Curt Simmons vs Don Cardwell | Fourth | 8 out |
| Wednesday, July 6 |
| » Lost to Cubs (29-43), 10-1 | Wrigley Field (2-4) | 38-38 | |
| » Starters: Bob Gibson vs Glen Hobbie | Fifth | 9 out |
| » Major-league debuts: Ed Bauta (Cardinals) |
| Thursday, July 7 |
| » Defeated Giants (39-36), 7-3 | Candlestick Park (3-4) | 39-38 | |
| » Starters: Larry Jackson vs Sam Jones | Fifth | 9 out |
| Friday, July 8 |
| » Defeated Giants (39-37), 7-1 | Candlestick Park (4-4) | 40-38 | Won 2 |
| » Starters: Ray Sadecki vs Jack Sanford | Fourth | 8½ out |
| Saturday, July 9 |
| » Defeated Dodgers (40-38), 4-3 | Los Angeles Memorial Coliseum (3-4) | 41-38 | Won 3 |
| » Starters: Ernie Broglio vs Johnny Podres | Third | 7½ out |
| Sunday, July 10 |
| » Lost to Dodgers (41-38), 11-7 | Los Angeles Memorial Coliseum (3-5) | 41-39 | |
| » Starters: Ron Kline vs Stan Williams | Fifth | 8½ out |
| Friday, July 15 |
| » Defeated Cubs (30-47), 6-0 | Sportsman's Park III (25-12) | 42-39 | |
| » Starters: Don Cardwell vs Ernie Broglio | Fourth | 7 out |
| Saturday, July 16 |
| » Defeated Cubs (30-48), 2-1 | Sportsman's Park III (26-12) | 43-39 | Won 2 |
| » Starters: Glen Hobbie vs Curt Simmons | Fourth | 7 out |
| Future Cardinal Terry Pendleton is born in Los Angeles, CA. |
| Sunday, July 17 |
| » Defeated Cubs (30-49), 6-0 | Sportsman's Park III (27-12) | 44-39 | Won 3 |
| » Starters: Dick Ellsworth vs Larry Jackson | Third | 6 out |
| » Defeated Cubs (30-50), 8-1 | Sportsman's Park III (28-12) | 45-39 | Won 4 |
| » Starters: Bob Anderson vs Ray Sadecki | Third | 6 out |
| » Major-league debuts: Jim Brewer (Cubs) |
| Tuesday, July 19 |
| » Lost to Braves (48-34), 9-5 | County Stadium (1-6) | 45-40 | |
| » Starters: Bob Gibson vs Bob Buhl | Fourth | 6 out |
| Wednesday, July 20 |
| » Lost to Braves (49-34), 3-0 | County Stadium (1-7) | 45-41 | Lost 2 |
| » Starters: Ernie Broglio vs Warren Spahn | Fourth | 6 out |
| Thursday, July 21 |
| » Defeated Braves (49-35), 9-4 | County Stadium (2-7) | 46-41 | |
| » Starters: Larry Jackson vs Carl Willey | Third | 6 out |
| Friday, July 22 |
| » Defeated Reds (40-47), 8-3 | Crosley Field (4-3) | 47-41 | Won 2 |
| » Starters: Curt Simmons vs Joe Nuxhall | Fourth | 6 out |
| Saturday, July 23 |
| » Defeated Reds (40-48), 7-5 | Crosley Field (5-3) | 48-41 | Won 3 |
| » Starters: Ray Sadecki vs Jim O'Toole | Fourth | 5 out |
| Sunday, July 24 |
| » Defeated Reds (40-49), 6-5 | Crosley Field (6-3) | 49-41 | Won 4 |
| » Starters: Ernie Broglio vs Jay Hook | Fourth | 4 out |
| Monday, July 25 |
| » Lost to Pirates (54-37), 4-2 | Sportsman's Park III (28-13) | 49-42 | |
| » Starters: Bob Friend vs Larry Jackson | Fourth | 5 out |
| Tuesday, July 26 |
| » Lost to Pirates (55-37), 5-4 | Sportsman's Park III (28-14) | 49-43 | Lost 2 |
| » Starters: Vern Law vs Curt Simmons | Fourth | 6 out |
| Wednesday, July 27 |
| » Lost to Pirates (56-37), 7-3 | Sportsman's Park III (28-15) | 49-44 | Lost 3 |
| » Starters: George Witt vs Ray Sadecki | Fourth | 7 out |
| Thursday, July 28 |
| Former Cardinal Marty Kavanagh dies in Taylor, MI at the age of 70. |
| Friday, July 29 |
| » Defeated Phillies (38-56), 3-0 | Sportsman's Park III (29-15) | 50-44 | |
| » Starters: John Buzhardt vs Ernie Broglio | Fourth | 7 out |
| Saturday, July 30 |
| » Defeated Phillies (38-57), 6-3 | Sportsman's Park III (30-15) | 51-44 | Won 2 |
| » Starters: Chris Short vs Larry Jackson | Fourth | 6 out |
| » Major-league debuts: Art Mahaffey (Phillies) |
| Sunday, July 31 |
| » Defeated Phillies (38-58), 9-2 | Sportsman's Park III (31-15) | 52-44 | Won 3 |
| » Starters: Gene Conley vs Curt Simmons | Fourth | 4½ out |
| » Defeated Phillies (38-59), 5-3 | Sportsman's Park III (32-15) | 53-44 | Won 4 |
| » Starters: Robin Roberts vs Ray Sadecki | Fourth | 4½ out |
| Tuesday, August 2 |
| » Defeated Braves (54-41), 4-2 | Sportsman's Park III (33-15) | 54-44 | Won 5 |
| » Starters: Carl Willey vs Ernie Broglio | Third | 4½ out |
| » Major-league debuts: Charlie James (Cardinals) |
| Wednesday, August 3 |
| » Defeated Braves (54-42), 13-8 | Sportsman's Park III (34-15) | 55-44 | Won 6 |
| » Starters: Warren Spahn vs Larry Jackson | Third | 3½ out |
| Thursday, August 4 |
| » Defeated Braves (54-43), 4-2 | Sportsman's Park III (35-15) | 56-44 | Won 7 |
| » Starters: Bob Buhl vs Ray Sadecki | Second | 3½ out |
| Friday, August 5 |
| » Lost to Reds (44-57), 3-0 | Sportsman's Park III (35-16) | 56-45 | |
| » Starters: Bob Purkey vs Curt Simmons | Third | 4½ out |
| Saturday, August 6 |
| » Defeated Reds (44-58), 6-5 | Sportsman's Park III (36-16) | 57-45 | |
| » Starters: Jim Maloney vs Ernie Broglio | Second | 4½ out |
| » Major-league debuts: Julio Gotay (Cardinals) |
| Sunday, August 7 |
| » Lost to Reds (45-58), 18-4 | Sportsman's Park III (36-17) | 57-46 | |
| » Starters: Jay Hook vs Larry Jackson | Third | 5½ out |
| » Defeated Reds (45-59), 4-2 | Sportsman's Park III (37-17) | 58-46 | |
| » Starters: Jim O'Toole vs Bob Gibson | Third | 5½ out |
| Tuesday, August 9 |
| » Defeated Phillies (42-63), 5-4 | Shibe Park (4-2) | 59-46 | Won 2 |
| » Starters: Ray Sadecki vs Art Mahaffey | Second | 5 out |
| » Defeated Phillies (42-64), 6-0 | Shibe Park (5-2) | 60-46 | Won 3 |
| » Starters: Curt Simmons vs Gene Conley | Second | 5 out |
| Wednesday, August 10 |
| » Defeated Phillies (42-65), 6-5 | Shibe Park (6-2) | 61-46 | Won 4 |
| » Starters: Larry Jackson vs Jim Owens | Second | 5 out |
| Thursday, August 11 |
| » Defeated Pirates (65-41), 3-2 | Forbes Field (2-4) | 62-46 | Won 5 |
| » Starters: Ernie Broglio vs Bob Friend | Second | 4 out |
| Friday, August 12 |
| » Defeated Pirates (65-42), 9-2 | Forbes Field (3-4) | 63-46 | Won 6 |
| » Starters: Bob Gibson vs George Witt | Second | 3 out |
| Saturday, August 13 |
| » Lost to Pirates (66-42), 4-1 | Forbes Field (3-5) | 63-47 | |
| » Starters: Ray Sadecki vs Harvey Haddix | Second | 4 out |
| Sunday, August 14 |
| » Lost to Pirates (67-42), 9-4 | Forbes Field (3-6) | 63-48 | Lost 2 |
| » Starters: Larry Jackson vs Vern Law | Second | 6 out |
| » Lost to Pirates (68-42), 3-2 | Forbes Field (3-7) | 63-49 | Lost 3 |
| » Starters: Curt Simmons vs Tom Cheney | Second | 6 out |
| Monday, August 15 |
| » Lost to Giants (53-55), 5-3 | Sportsman's Park III (37-18) | 63-50 | Lost 4 |
| » Starters: Billy O'Dell vs Ernie Broglio | Second | 6 out |
| Tuesday, August 16 |
| » Lost to Giants (54-55), 7-3 | Sportsman's Park III (37-19) | 63-51 | Lost 5 |
| » Starters: Juan Marichal vs Bob Gibson | Third | 7½ out |
| Wednesday, August 17 |
| » Lost to Giants (55-55), 6-5 | Sportsman's Park III (37-20) | 63-52 | Lost 6 |
| » Starters: Jack Sanford vs Ray Sadecki | Third | 8½ out |
| Thursday, August 18 |
| Future Cardinal Mike LaValliere is born in Charlotte, NC. |
| Friday, August 19 |
| » Defeated Dodgers (61-51), 1-0 | Sportsman's Park III (38-20) | 64-52 | |
| » Starters: Johnny Podres vs Larry Jackson | Third | 8 out |
| Saturday, August 20 |
| » Lost to Dodgers (62-51), 2-1 | Sportsman's Park III (38-21) | 64-53 | |
| » Starters: Danny McDevitt vs Curt Simmons | Fourth | 9 out |
| Future Cardinal Tom Brunansky is born in Covina, CA. |
| Sunday, August 21 |
| » Defeated Dodgers (62-52), 2-0 | Sportsman's Park III (39-21) | 65-53 | |
| » Starters: Sandy Koufax vs Ernie Broglio | Third | 8 out |
| Tuesday, August 23 |
| » Defeated Phillies (45-75), 4-2 | Sportsman's Park III (40-21) | 66-53 | Won 2 |
| » Starters: Gene Conley vs Ray Sadecki | Third | 8 out |
| Wednesday, August 24 |
| » Lost to Phillies (46-75), 5-3 | Sportsman's Park III (40-22) | 66-54 | |
| » Starters: Art Mahaffey vs Larry Jackson | Third | 9 out |
| Friday, August 26 |
| » Defeated Pirates (75-47), 3-1 | Sportsman's Park III (41-22) | 67-54 | |
| » Starters: Bob Friend vs Ernie Broglio | Third | 7½ out |
| Saturday, August 27 |
| » Defeated Pirates (75-48), 5-4 | Sportsman's Park III (42-22) | 68-54 | Won 2 |
| » Starters: Tom Cheney vs Bob Gibson | Third | 6½ out |
| Sunday, August 28 |
| » Defeated Pirates (75-49), 5-4 | Sportsman's Park III (43-22) | 69-54 | Won 3 |
| » Starters: Harvey Haddix vs Curt Simmons | Third | 5½ out |
| Monday, August 29 |
| » Defeated Braves (68-54), 3-0 | County Stadium (3-7) | 70-54 | Won 4 |
| » Starters: Larry Jackson vs Joey Jay | Second | 5½ out |
| Tuesday, August 30 |
| » Lost to Braves (69-54), 10-0 | County Stadium (3-8) | 70-55 | |
| » Starters: Ernie Broglio vs Warren Spahn | Third | 6½ out |
| Future Cardinal Randy O'Neal is born in Ashland, KY. |
| Wednesday, August 31 |
| » Defeated Reds (56-72), 2-1 | Crosley Field (7-3) | 71-55 | |
| » Starters: Ray Sadecki vs Jay Hook | Second | 6½ out |
| Thursday, September 1 |
| » Lost to Reds (57-72), 7-4 | Crosley Field (7-4) | 71-56 | |
| » Starters: Bob Gibson vs Bob Purkey | Third | 7½ out |
| Friday, September 2 |
| » Lost to Cubs (52-75), 10-4 | Sportsman's Park III (43-23) | 71-57 | Lost 2 |
| » Starters: Don Cardwell vs Larry Jackson | Third | 8 out |
| Future Cardinal Rex Hudler is born in Tempe, AZ. |
| Saturday, September 3 |
| » Defeated Cubs (52-76), 4-0 | Sportsman's Park III (44-23) | 72-57 | |
| » Starters: Glen Hobbie vs Ernie Broglio | Third | 7 out |
| Sunday, September 4 |
| » Defeated Cubs (52-77), 4-3 | Sportsman's Park III (45-23) | 73-57 | Won 2 |
| » Starters: Dick Ellsworth vs Curt Simmons | Third | 7 out |
| Monday, September 5 |
| » Defeated Cubs (52-78), 2-1 | Wrigley Field (3-4) | 74-57 | Won 3 |
| » Starters: Larry Jackson vs Bob Anderson | Second | 6½ out |
| » Tied Cubs, 4-4 | Wrigley Field (3-4) | 74-57 | |
| » Starters: Ray Sadecki vs Moe Drabowsky | Second | 6½ out |
| Wednesday, September 7 |
| » Defeated Pirates (82-52), 2-1 | Forbes Field (4-7) | 75-57 | Won 4 |
| » Starters: Ernie Broglio vs Vern Law | Second | 6 out |
| Friday, September 9 |
| » Defeated Phillies (50-85), 4-1 | Shibe Park (7-2) | 76-57 | Won 5 |
| » Starters: Larry Jackson vs Robin Roberts | Second | 6 out |
| Saturday, September 10 |
| » Lost to Phillies (51-85), 7-2 | Shibe Park (7-3) | 76-58 | |
| » Starters: Ray Sadecki vs Jim Owens | Second | 7 out |
| Sunday, September 11 |
| » Defeated Phillies (51-86), 7-3 | Shibe Park (8-3) | 77-58 | |
| » Starters: Curt Simmons vs John Buzhardt | Second | 6½ out |
| Monday, September 12 |
| » Lost to Braves (78-60), 4-2 | Sportsman's Park III (45-24) | 77-59 | |
| » Starters: Warren Spahn vs Bob Gibson | Second | 7½ out |
| Tuesday, September 13 |
| » Defeated Braves (78-61), 6-5 | Sportsman's Park III (46-24) | 78-59 | |
| » Starters: Bob Buhl vs Larry Jackson | Second | 6½ out |
| Wednesday, September 14 |
| » Defeated Reds (64-78), 6-4 | Sportsman's Park III (47-24) | 79-59 | Won 2 |
| » Starters: Jay Hook vs Ray Sadecki | Second | 5½ out |
| Friday, September 16 |
| » Lost to Giants (71-71), 6-2 | Sportsman's Park III (47-25) | 79-60 | |
| » Starters: Juan Marichal vs Curt Simmons | Third | 6 out |
| » Major-league debuts: Ed Olivares and Bob Sadowski (Cardinals) |
| Saturday, September 17 |
| » Defeated Giants (71-72), 4-1 | Sportsman's Park III (48-25) | 80-60 | |
| » Starters: Jack Sanford vs Larry Jackson | Second | 5½ out |
| Sunday, September 18 |
| » Defeated Giants (71-73), 4-3 | Sportsman's Park III (49-25) | 81-60 | Won 2 |
| » Starters: Mike McCormick vs Ernie Broglio | Second | 6 out |
| Monday, September 19 |
| » Defeated Dodgers (77-67), 1-0 | Sportsman's Park III (50-25) | 82-60 | Won 3 |
| » Starters: Stan Williams vs Bob Miller | Second | 5½ out |
| Tuesday, September 20 |
| » Defeated Dodgers (77-68), 3-2 | Sportsman's Park III (51-25) | 83-60 | Won 4 |
| » Starters: Roger Craig vs Curt Simmons | Second | 6 out |
| Wednesday, September 21 |
| » Lost to Dodgers (78-68), 5-3 | Sportsman's Park III (51-26) | 83-61 | |
| » Starters: Don Drysdale vs Larry Jackson | Second | 6½ out |
| Thursday, September 22 |
| » Major-league debuts: Dick Bertell (Cubs) |
| Friday, September 23 |
| » Defeated Cubs (55-91), 5-1 | Wrigley Field (4-4) | 84-61 | |
| » Starters: Ernie Broglio vs Glen Hobbie | Second | 6 out |
| » Defeated Cubs (55-92), 5-1 | Wrigley Field (5-4) | 85-61 | Won 2 |
| » Starters: Ray Sadecki vs Seth Morehead | Second | 6 out |
| Saturday, September 24 |
| » Lost to Cubs (56-92), 5-4 | Wrigley Field (5-5) | 85-62 | |
| » Starters: Bob Miller vs Dick Ellsworth | Second | 6 out |
| Sunday, September 25 |
| » Lost to Cubs (57-92), 5-0 | Wrigley Field (5-6) | 85-63 | Lost 2 |
| » Starters: Larry Jackson vs Glen Hobbie | Third | 6 out |
| Monday, September 26 |
| » Major-league debuts: Matty Alou (Giants) |
| Tuesday, September 27 |
| » Lost to Dodgers (79-70), 5-1 | Los Angeles Memorial Coliseum (3-6) | 85-64 | Lost 3 |
| » Starters: Ernie Broglio vs Roger Craig | Third | 7 out |
| » Major-league debuts: Mel Nelson (Cardinals) |
| Wednesday, September 28 |
| » Lost to Dodgers (80-70), 4-2 | Los Angeles Memorial Coliseum (3-7) | 85-65 | Lost 4 |
| » Starters: Bob Miller vs Johnny Podres | Third | 7½ out |
| Thursday, September 29 |
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