| Saturday, January 10 |
| Future White Sox Rich Dotson is born in Cincinnati, OH. |
| Thursday, January 22 |
| Former White Sox Ken Williams dies in Grants Pass, OR at the age of 69. |
| Tuesday, February 10 |
| Future White Sox Al Jones is born in Charleston, MS. |
| Wednesday, March 11 |
| Future White Sox Phil Bradley is born in Bloomington, IN. |
| Sunday, March 15 |
| Future White Sox Harold Baines is born in Easton, MD. |
| Friday, April 10 |
| » Defeated Tigers (0-1), 9-7 | Tiger Stadium (1-0) | 1-0 | |
| » Starters: Billy Pierce vs Jim Bunning | First | -- |
| » Major-league debuts: Rudy Arias (White Sox) |
| Saturday, April 11 |
| » Defeated Tigers (0-2), 5-3 | Tiger Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Early Wynn vs Paul Foytack | First | -- |
| Sunday, April 12 |
| » Defeated Tigers (0-3), 5-3 | Tiger Stadium (3-0) | 3-0 | Won 3 |
| » Starters: Dick Donovan vs Frank Lary | First | -- |
| Tuesday, April 14 |
| » Defeated Athletics (0-3), 2-0 | Comiskey Park I (1-0) | 4-0 | Won 4 |
| » Starters: Ralph Terry vs Billy Pierce | First | -- |
| Wednesday, April 15 |
| » Lost to Athletics (1-3), 10-8 | Comiskey Park I (1-1) | 4-1 | |
| » Starters: Bob Grim vs Barry Latman | Third | ½ out |
| » Major-league debuts: Claude Raymond (White Sox) |
| Thursday, April 16 |
| » Lost to Athletics (2-3), 6-0 | Comiskey Park I (1-2) | 4-2 | Lost 2 |
| » Starters: Ned Garver vs Early Wynn | Third | 1 out |
| Friday, April 17 |
| » Defeated Tigers (0-6), 6-5 | Comiskey Park I (2-2) | 5-2 | |
| » Starters: Frank Lary vs Dick Donovan | Second | 1 out |
| Saturday, April 18 |
| » Lost to Tigers (1-6), 5-2 | Comiskey Park I (2-3) | 5-3 | |
| » Starters: Billy Hoeft vs Ray Moore | Third | 2 out |
| Tuesday, April 21 |
| » Lost to Athletics (4-5), 8-3 | Municipal Stadium (0-1) | 5-4 | Lost 2 |
| » Starters: Billy Pierce vs Bob Grim | Third | 2½ out |
| Wednesday, April 22 |
| » Defeated Athletics (4-6), 20-6 | Municipal Stadium (1-1) | 6-4 | |
| » Starters: Early Wynn vs Ned Garver | Third | 2½ out |
| Thursday, April 23 |
| » Major-league debuts: Jim Perry (Indians) |
| Friday, April 24 |
| » Lost to Indians (10-1), 6-4 | Cleveland Stadium (0-1) | 6-5 | |
| » Starters: Dick Donovan vs Herb Score | Third | 4 out |
| » Major-league debuts: Don Dillard (Indians) |
| Saturday, April 25 |
| » Defeated Indians (10-2), 8-6 | Cleveland Stadium (1-1) | 7-5 | |
| » Starters: Barry Latman vs Cal McLish | Second | 3 out |
| Sunday, April 26 |
| » Defeated Indians (10-3), 6-5 | Cleveland Stadium (2-1) | 8-5 | Won 2 |
| » Starters: Early Wynn vs Don Ferrarese | Second | 1 out |
| » Defeated Indians (10-4), 5-2 | Cleveland Stadium (3-1) | 9-5 | Won 3 |
| » Starters: Billy Pierce vs Gary Bell | Second | 1 out |
| Wednesday, April 29 |
| » Lost to Yankees (7-7), 5-2 | Comiskey Park I (2-4) | 9-6 | |
| » Starters: Bob Turley vs Ray Moore | Second | 1½ out |
| Thursday, April 30 |
| » Defeated Yankees (7-8), 4-3 | Comiskey Park I (3-4) | 10-6 | |
| » Starters: Whitey Ford vs Billy Pierce | Second | 1 out |
| Friday, May 1 |
| » Defeated Red Sox (6-8), 1-0 | Comiskey Park I (4-4) | 11-6 | Won 2 |
| » Starters: Tom Brewer vs Early Wynn | Second | 1 out |
| Saturday, May 2 |
| » Lost to Red Sox (7-8), 5-4 | Comiskey Park I (4-5) | 11-7 | |
| » Starters: Ike Delock vs Barry Latman | Second | 2 out |
| Sunday, May 3 |
| » Lost to Orioles (11-8), 4-2 | Comiskey Park I (4-6) | 11-8 | Lost 2 |
| » Starters: Billy O'Dell vs Dick Donovan | Second | 2½ out |
| Tuesday, May 5 |
| » Lost to Senators (12-10), 8-3 | Comiskey Park I (4-7) | 11-9 | Lost 3 |
| » Starters: Chuck Stobbs vs Billy Pierce | Second | 3½ out |
| Wednesday, May 6 |
| » Lost to Senators (13-10), 6-4 | Comiskey Park I (4-8) | 11-10 | Lost 4 |
| » Starters: Camilo Pascual vs Early Wynn | Fourth | 3½ out |
| Friday, May 8 |
| » Lost to Indians (15-6), 3-1 | Comiskey Park I (4-9) | 11-11 | Lost 5 |
| » Starters: Cal McLish vs Dick Donovan | Fourth | 4½ out |
| Saturday, May 9 |
| » Defeated Indians (15-7), 9-5 | Comiskey Park I (5-9) | 12-11 | |
| » Starters: Herb Score vs Barry Latman | Fourth | 3½ out |
| Sunday, May 10 |
| » Defeated Indians (15-8), 5-4 | Comiskey Park I (6-9) | 13-11 | Won 2 |
| » Starters: Mudcat Grant vs Billy Pierce | Second | 1½ out |
| » Defeated Indians (15-9), 5-0 | Comiskey Park I (7-9) | 14-11 | Won 3 |
| » Starters: Mike Garcia vs Early Wynn | Second | 1½ out |
| Tuesday, May 12 |
| » Defeated Red Sox (12-13), 4-3 | Fenway Park (1-0) | 15-11 | Won 4 |
| » Starters: Dick Donovan vs Ike Delock | Second | 1½ out |
| Wednesday, May 13 |
| » Defeated Red Sox (12-14), 4-0 | Fenway Park (2-0) | 16-11 | Won 5 |
| » Starters: Bob Shaw vs Frank Sullivan | Second | 1 out |
| Thursday, May 14 |
| » Defeated Red Sox (12-15), 14-6 | Fenway Park (3-0) | 17-11 | Won 6 |
| » Starters: Early Wynn vs Billy Hoeft | Second | 1½ out |
| Friday, May 15 |
| » Defeated Yankees (11-15), 6-0 | Yankee Stadium (1-0) | 18-11 | Won 7 |
| » Starters: Billy Pierce vs Whitey Ford | Second | 1½ out |
| Saturday, May 16 |
| » Defeated Yankees (11-16), 4-3 | Yankee Stadium (2-0) | 19-11 | Won 8 |
| » Starters: Ray Moore vs Bob Turley | Second | 1½ out |
| Sunday, May 17 |
| » Lost to Senators (17-16), 4-2 | Griffith Stadium (0-1) | 19-12 | |
| » Starters: Dick Donovan vs Pedro Ramos | Second | 1½ out |
| » Defeated Senators (17-17), 10-7 | Griffith Stadium (1-1) | 20-12 | |
| » Starters: Bob Shaw vs Bill Fischer | Second | 1½ out |
| Monday, May 18 |
| » Defeated Senators (17-18), 9-2 | Griffith Stadium (2-1) | 21-12 | Won 2 |
| » Starters: Early Wynn vs Chuck Stobbs | First | -- |
| Tuesday, May 19 |
| » Lost to Orioles (20-14), 2-1 | Memorial Stadium (0-1) | 21-13 | |
| » Starters: Billy Pierce vs Billy O'Dell | Second | 1½ out |
| Wednesday, May 20 |
| » Defeated Orioles (20-15), 5-2 | Memorial Stadium (1-1) | 22-13 | |
| » Starters: Dick Donovan vs Jack Harshman | Second | 1½ out |
| Friday, May 22 |
| » Defeated Athletics (15-18), 2-1 | Municipal Stadium (2-1) | 23-13 | Won 2 |
| » Starters: Bob Shaw vs Bob Grim | Second | 1½ out |
| Saturday, May 23 |
| » Lost to Athletics (16-18), 16-0 | Municipal Stadium (2-2) | 23-14 | |
| » Starters: Early Wynn vs Bud Daley | Second | 1½ out |
| Sunday, May 24 |
| » Lost to Athletics (17-18), 8-6 | Municipal Stadium (2-3) | 23-15 | Lost 2 |
| » Starters: Billy Pierce vs Ray Herbert | Second | 1 out |
| Monday, May 25 |
| Former White Sox Dave Brain dies in Los Angeles, CA at the age of 81. |
| Tuesday, May 26 |
| » Lost to Indians (24-13), 3-0 | Comiskey Park I (7-10) | 23-16 | Lost 3 |
| » Starters: Don Ferrarese vs Dick Donovan | Second | 2 out |
| Former White Sox Ed Walsh dies in Pompano Beach, FL at the age of 79. |
| Wednesday, May 27 |
| » Defeated Indians (24-14), 5-1 | Comiskey Park I (8-10) | 24-16 | |
| » Starters: Gary Bell vs Early Wynn | Second | 1 out |
| Future White Sox Ron Tingley is born in Presque Isle, ME. |
| Friday, May 29 |
| » Lost to Tigers (18-22), 4-1 | Comiskey Park I (8-11) | 24-17 | |
| » Starters: Don Mossi vs Bob Shaw | Second | 1 out |
| Saturday, May 30 |
| » Lost to Tigers (19-22), 4-2 | Comiskey Park I (8-12) | 24-18 | Lost 2 |
| » Starters: Frank Lary vs Billy Pierce | Second | 1 out |
| » Defeated Tigers (19-23), 4-3 | Comiskey Park I (9-12) | 25-18 | |
| » Starters: Jim Bunning vs Dick Donovan | Second | 1 out |
| Sunday, May 31 |
| » Lost to Athletics (20-21), 9-1 | Comiskey Park I (9-13) | 25-19 | |
| » Starters: Ned Garver vs Early Wynn | Second | 1 out |
| Monday, June 1 |
| » Lost to Athletics (21-21), 3-1 | Comiskey Park I (9-14) | 25-20 | Lost 2 |
| » Starters: Bud Daley vs Ray Moore | Second | 1 out |
| Tuesday, June 2 |
| » Lost to Orioles (26-21), 3-2 | Comiskey Park I (9-15) | 25-21 | Lost 3 |
| » Starters: Hoyt Wilhelm vs Bob Shaw | Third | 1 out |
| Wednesday, June 3 |
| » Defeated Orioles (26-22), 6-1 | Comiskey Park I (10-15) | 26-21 | |
| » Starters: Billy O'Dell vs Billy Pierce | Second | 1 out |
| Thursday, June 4 |
| » Defeated Orioles (26-23), 6-5 | Comiskey Park I (11-15) | 27-21 | Won 2 |
| » Starters: Jack Harshman vs Dick Donovan | First | -- |
| Friday, June 5 |
| » Defeated Red Sox (20-27), 5-2 | Comiskey Park I (12-15) | 28-21 | Won 3 |
| » Starters: Frank Baumann vs Early Wynn | First | -- |
| Saturday, June 6 |
| » Lost to Red Sox (21-27), 4-2 | Comiskey Park I (12-16) | 28-22 | |
| » Starters: Ted Wills vs Ray Moore | First | -- |
| Sunday, June 7 |
| » Defeated Red Sox (21-28), 9-4 | Comiskey Park I (13-16) | 29-22 | |
| » Starters: Ike Delock vs Dick Donovan | First | -- |
| » Lost to Red Sox (22-28), 4-2 | Comiskey Park I (13-17) | 29-23 | |
| » Starters: Frank Sullivan vs Billy Pierce | First | -- |
| Monday, June 8 |
| Future White Sox Britt Burns is born in Houston, TX. |
| Tuesday, June 9 |
| » Lost to Senators (24-29), 7-4 | Griffith Stadium (2-2) | 29-24 | Lost 2 |
| » Starters: Bob Shaw vs Bill Fischer | First | -- |
| Former White Sox Frank Huelsman dies in Affton, MO at the age of 86. |
| Wednesday, June 10 |
| » Defeated Senators (24-30), 4-1 | Griffith Stadium (3-2) | 30-24 | |
| » Starters: Early Wynn vs Hal Woodeshick | First | -- |
| Thursday, June 11 |
| » Defeated Senators (24-31), 3-1 | Griffith Stadium (4-2) | 31-24 | Won 2 |
| » Starters: Billy Pierce vs Camilo Pascual | First | -- |
| Saturday, June 13 |
| » Lost to Orioles (30-26), 6-4 | Memorial Stadium (1-2) | 31-25 | |
| » Starters: Bob Shaw vs Hal Brown | First | -- |
| Sunday, June 14 |
| » Defeated Orioles (30-27), 9-6 | Memorial Stadium (2-2) | 32-25 | |
| » Starters: Early Wynn vs Jack Harshman | First | -- |
| » Defeated Orioles (30-28), 3-2 | Memorial Stadium (3-2) | 33-25 | Won 2 |
| » Starters: Dick Donovan vs Billy O'Dell | First | -- |
| Tuesday, June 16 |
| » Lost to Yankees (28-29), 5-1 | Yankee Stadium (2-1) | 33-26 | |
| » Starters: Billy Pierce vs Art Ditmar | Second | 1 out |
| Wednesday, June 17 |
| » Lost to Yankees (29-29), 7-3 | Yankee Stadium (2-2) | 33-27 | Lost 2 |
| » Starters: Ray Moore vs Bob Turley | Second | 1½ out |
| Thursday, June 18 |
| » Lost to Yankees (30-29), 5-4 | Yankee Stadium (2-3) | 33-28 | Lost 3 |
| » Starters: Bob Shaw vs Jim Bronstad | Second | 1½ out |
| Saturday, June 20 |
| » Lost to Red Sox (27-34), 8-2 | Fenway Park (3-1) | 33-29 | Lost 4 |
| » Starters: Early Wynn vs Tom Brewer | Fifth | 1½ out |
| » Lost to Red Sox (28-34), 9-0 | Fenway Park (3-2) | 33-30 | Lost 5 |
| » Starters: Dick Donovan vs Jerry Casale | Fifth | 1½ out |
| Sunday, June 21 |
| » Defeated Red Sox (28-35), 3-2 | Fenway Park (4-2) | 34-30 | |
| » Starters: Billy Pierce vs Ted Wills | Second | 2 out |
| Monday, June 22 |
| » Major-league debuts: Eddie Fisher (Giants) |
| Tuesday, June 23 |
| » Defeated Senators (29-37), 4-1 | Comiskey Park I (14-17) | 35-30 | Won 2 |
| » Starters: Bill Fischer vs Early Wynn | Second | 1 out |
| Wednesday, June 24 |
| » Lost to Senators (30-37), 4-2 | Comiskey Park I (14-18) | 35-31 | |
| » Starters: Russ Kemmerer vs Dick Donovan | Third | 1 out |
| Thursday, June 25 |
| » Defeated Senators (30-38), 4-1 | Comiskey Park I (15-18) | 36-31 | |
| » Starters: Pedro Ramos vs Barry Latman | Second | 1 out |
| Friday, June 26 |
| » Lost to Yankees (36-32), 8-4 | Comiskey Park I (15-19) | 36-32 | |
| » Starters: Art Ditmar vs Billy Pierce | Third | 2 out |
| Saturday, June 27 |
| » Defeated Yankees (36-33), 5-4 | Comiskey Park I (16-19) | 37-32 | |
| » Starters: Bob Turley vs Bob Shaw | Second | 1 out |
| Sunday, June 28 |
| » Defeated Yankees (36-34), 9-2 | Comiskey Park I (17-19) | 38-32 | Won 2 |
| » Starters: Whitey Ford vs Early Wynn | Second | 1 out |
| » Defeated Yankees (36-35), 4-2 | Comiskey Park I (18-19) | 39-32 | Won 3 |
| » Starters: Don Larsen vs Dick Donovan | Second | 1 out |
| Tuesday, June 30 |
| » Lost to Indians (40-30), 3-1 | Cleveland Stadium (3-2) | 39-33 | |
| » Starters: Billy Pierce vs Cal McLish | Second | 2 out |
| Wednesday, July 1 |
| » Defeated Indians (40-31), 6-5 | Cleveland Stadium (4-2) | 40-33 | |
| » Starters: Barry Latman vs Mudcat Grant | Second | 1 out |
| Thursday, July 2 |
| » Lost to Tigers (40-36), 9-7 | Tiger Stadium (3-1) | 40-34 | |
| » Starters: Bob Shaw vs Don Mossi | Second | 1 out |
| Friday, July 3 |
| » Defeated Tigers (40-37), 6-5 | Tiger Stadium (4-1) | 41-34 | |
| » Starters: Early Wynn vs Jim Bunning | Second | 1 out |
| Former White Sox Red Barnes dies in Mobile, AL at the age of 55. |
| Saturday, July 4 |
| » Defeated Athletics (32-42), 7-4 | Municipal Stadium (3-3) | 42-34 | Won 2 |
| » Starters: Dick Donovan vs Bud Daley | Second | 2 out |
| » Lost to Athletics (33-42), 8-3 | Municipal Stadium (3-4) | 42-35 | |
| » Starters: Billy Pierce vs Rip Coleman | Second | 2 out |
| Sunday, July 5 |
| » Defeated Athletics (33-43), 4-3 | Municipal Stadium (4-4) | 43-35 | |
| » Starters: Barry Latman vs Ned Garver | Second | 2 out |
| Thursday, July 9 |
| » Defeated Indians (44-33), 4-3 | Comiskey Park I (19-19) | 44-35 | Won 2 |
| » Starters: Herb Score vs Billy Pierce | Second | 1 out |
| Friday, July 10 |
| » Lost to Indians (45-33), 8-4 | Comiskey Park I (19-20) | 44-36 | |
| » Starters: Cal McLish vs Early Wynn | Second | 2 out |
| Saturday, July 11 |
| » Defeated Athletics (35-45), 8-3 | Comiskey Park I (20-20) | 45-36 | |
| » Starters: Ned Garver vs Barry Latman | Second | 2 out |
| Sunday, July 12 |
| » Defeated Athletics (35-46), 5-3 | Comiskey Park I (21-20) | 46-36 | Won 2 |
| » Starters: Bud Daley vs Dick Donovan | Second | 1 out |
| » Defeated Athletics (35-47), 9-7 | Comiskey Park I (22-20) | 47-36 | Won 3 |
| » Starters: Rip Coleman vs Bob Shaw | Second | 1 out |
| Tuesday, July 14 |
| » Defeated Red Sox (38-46), 7-3 | Fenway Park (5-2) | 48-36 | Won 4 |
| » Starters: Billy Pierce vs Ted Wills | Second | 1 out |
| Thursday, July 16 |
| » Defeated Red Sox (38-47), 4-3 | Fenway Park (6-2) | 49-36 | Won 5 |
| » Starters: Dick Donovan vs Tom Brewer | First | -- |
| » Lost to Red Sox (39-47), 5-4 | Fenway Park (6-3) | 49-37 | |
| » Starters: Barry Latman vs Jerry Casale | First | -- |
| Friday, July 17 |
| » Defeated Yankees (44-44), 2-0 | Yankee Stadium (3-3) | 50-37 | |
| » Starters: Early Wynn vs Ralph Terry | First | -- |
| Saturday, July 18 |
| » Defeated Yankees (44-45), 2-1 | Yankee Stadium (4-3) | 51-37 | Won 2 |
| » Starters: Bob Shaw vs Don Larsen | First | -- |
| Sunday, July 19 |
| » Lost to Yankees (45-45), 6-2 | Yankee Stadium (4-4) | 51-38 | |
| » Starters: Barry Latman vs Whitey Ford | Second | 1 out |
| » Lost to Yankees (46-45), 6-4 | Yankee Stadium (4-5) | 51-39 | Lost 2 |
| » Starters: Billy Pierce vs Eli Grba | Second | 1 out |
| Tuesday, July 21 |
| » Defeated Red Sox (40-51), 2-1 | Comiskey Park I (23-20) | 52-39 | |
| » Starters: Tom Brewer vs Dick Donovan | Second | 1 out |
| » Major-league debuts: Pumpsie Green (Red Sox) |
| Future White Sox Rich Barnes is born in Palm Beach, FL. |
| Wednesday, July 22 |
| » Defeated Red Sox (40-52), 5-4 | Comiskey Park I (24-20) | 53-39 | Won 2 |
| » Starters: Jerry Casale vs Early Wynn | First | -- |
| Friday, July 24 |
| » Defeated Orioles (48-47), 2-1 | Comiskey Park I (25-20) | 54-39 | Won 3 |
| » Starters: Hoyt Wilhelm vs Billy Pierce | First | -- |
| Saturday, July 25 |
| » Defeated Orioles (48-48), 3-2 | Comiskey Park I (26-20) | 55-39 | Won 4 |
| » Starters: Billy O'Dell vs Bob Shaw | First | -- |
| Former White Sox Buck O'Brien dies in Boston, MA at the age of 78. |
| Sunday, July 26 |
| » Defeated Orioles (48-49), 4-1 | Comiskey Park I (27-20) | 56-39 | Won 5 |
| » Starters: Arnie Portocarrero vs Early Wynn | Second | ½ out |
| » Lost to Orioles (49-49), 4-0 | Comiskey Park I (27-21) | 56-40 | |
| » Starters: Milt Pappas vs Barry Latman | Second | ½ out |
| Monday, July 27 |
| » Major-league debuts: Barry Shetrone (Orioles) |
| Future White Sox Joe DeSa is born in Honolulu, HI. |
| Tuesday, July 28 |
| » Defeated Yankees (48-50), 4-3 | Comiskey Park I (28-21) | 57-40 | |
| » Starters: Ralph Terry vs Billy Pierce | First | -- |
| Wednesday, July 29 |
| » Tied Yankees, 4-4 | Comiskey Park I (28-21) | 57-40 | |
| » Starters: Whitey Ford vs Bob Shaw | First | -- |
| Future White Sox Dave LaPoint is born in Glens Falls, NY. |
| Thursday, July 30 |
| » Defeated Yankees (48-51), 3-1 | Comiskey Park I (29-21) | 58-40 | Won 2 |
| » Starters: Eli Grba vs Early Wynn | First | -- |
| Future White Sox Rick Horton is born in Poughkeepsie, NY. |
| Friday, July 31 |
| » Defeated Senators (43-59), 7-1 | Comiskey Park I (30-21) | 59-40 | Won 3 |
| » Starters: Pedro Ramos vs Barry Latman | First | -- |
| Saturday, August 1 |
| » Defeated Senators (43-60), 2-1 | Comiskey Park I (31-21) | 60-40 | Won 4 |
| » Starters: Camilo Pascual vs Ray Moore | First | -- |
| » Major-league debuts: Zoilo Versalles (Senators) |
| Sunday, August 2 |
| » Defeated Senators (43-61), 3-2 | Comiskey Park I (32-21) | 61-40 | Won 5 |
| » Starters: Russ Kemmerer vs Billy Pierce | First | -- |
| » Defeated Senators (43-62), 9-3 | Comiskey Park I (33-21) | 62-40 | Won 6 |
| » Starters: Jim Kaat vs Bob Shaw | First | -- |
| » Major-league debuts: Jim Kaat (Senators) |
| Tuesday, August 4 |
| » Lost to Orioles (54-53), 3-2 | Memorial Stadium (3-3) | 62-41 | |
| » Starters: Ken McBride vs Billy Hoeft | First | -- |
| » Major-league debuts: Ken McBride (White Sox) |
| Wednesday, August 5 |
| » Defeated Orioles (54-54), 2-0 | Memorial Stadium (4-3) | 63-41 | |
| » Starters: Barry Latman vs Jack Fisher | First | -- |
| » Lost to Orioles (55-54), 7-1 | Memorial Stadium (4-4) | 63-42 | |
| » Starters: Early Wynn vs Arnie Portocarrero | First | -- |
| Thursday, August 6 |
| » Tied Orioles, 1-1 | Memorial Stadium (4-4) | 63-42 | |
| » Starters: Billy Pierce vs Billy O'Dell | First | -- |
| Friday, August 7 |
| » Defeated Senators (44-66), 4-1 | Griffith Stadium (5-2) | 64-42 | |
| » Starters: Bob Shaw vs Bill Fischer | First | -- |
| Sunday, August 9 |
| » Defeated Senators (44-67), 4-3 | Griffith Stadium (6-2) | 65-42 | Won 2 |
| » Starters: Ken McBride vs Chuck Stobbs | First | -- |
| » Defeated Senators (44-68), 9-0 | Griffith Stadium (7-2) | 66-42 | Won 3 |
| » Starters: Early Wynn vs Tex Clevenger | First | -- |
| Tuesday, August 11 |
| » Lost to Tigers (55-58), 8-1 | Tiger Stadium (4-2) | 66-43 | |
| » Starters: Billy Pierce vs Jim Bunning | First | -- |
| Wednesday, August 12 |
| » Defeated Tigers (55-59), 11-6 | Tiger Stadium (5-2) | 67-43 | |
| » Starters: Barry Latman vs Paul Foytack | First | -- |
| Thursday, August 13 |
| » Defeated Tigers (55-60), 9-0 | Tiger Stadium (6-2) | 68-43 | Won 2 |
| » Starters: Early Wynn vs Don Mossi | First | -- |
| Friday, August 14 |
| » Defeated Athletics (53-62), 5-1 | Municipal Stadium (5-4) | 69-43 | Won 3 |
| » Starters: Bob Shaw vs Johnny Kucks | First | -- |
| Saturday, August 15 |
| » Lost to Athletics (54-62), 2-1 | Municipal Stadium (5-5) | 69-44 | |
| » Starters: Billy Pierce vs Bud Daley | First | -- |
| Sunday, August 16 |
| » Lost to Athletics (55-62), 7-2 | Municipal Stadium (5-6) | 69-45 | Lost 2 |
| » Starters: Dick Donovan vs Ned Garver | First | -- |
| Tuesday, August 18 |
| » Defeated Orioles (57-59), 6-4 | Comiskey Park I (34-21) | 70-45 | |
| » Starters: Arnie Portocarrero vs Early Wynn | First | -- |
| Wednesday, August 19 |
| » Lost to Orioles (58-59), 3-1 | Comiskey Park I (34-22) | 70-46 | |
| » Starters: Billy O'Dell vs Bob Shaw | First | -- |
| Thursday, August 20 |
| » Lost to Orioles (59-59), 7-6 | Comiskey Park I (34-23) | 70-47 | Lost 2 |
| » Starters: Hoyt Wilhelm vs Barry Latman | First | -- |
| Friday, August 21 |
| » Defeated Senators (49-72), 5-4 | Comiskey Park I (35-23) | 71-47 | |
| » Starters: Chuck Stobbs vs Dick Donovan | First | -- |
| Saturday, August 22 |
| » Defeated Senators (49-73), 1-0 | Comiskey Park I (36-23) | 72-47 | Won 2 |
| » Starters: Russ Kemmerer vs Barry Latman | First | -- |
| Sunday, August 23 |
| » Lost to Yankees (62-61), 7-1 | Comiskey Park I (36-24) | 72-48 | |
| » Starters: Art Ditmar vs Early Wynn | First | -- |
| » Defeated Yankees (62-62), 5-0 | Comiskey Park I (37-24) | 73-48 | |
| » Starters: Ralph Terry vs Bob Shaw | First | -- |
| Monday, August 24 |
| » Defeated Yankees (62-63), 4-2 | Comiskey Park I (38-24) | 74-48 | Won 2 |
| » Starters: Don Larsen vs Ray Moore | First | -- |
| Tuesday, August 25 |
| » Defeated Red Sox (57-68), 5-4 | Comiskey Park I (39-24) | 75-48 | Won 3 |
| » Starters: Frank Sullivan vs Dick Donovan | First | -- |
| Wednesday, August 26 |
| » Lost to Red Sox (58-68), 7-6 | Comiskey Park I (39-25) | 75-49 | |
| » Starters: Bill Monbouquette vs Early Wynn | First | -- |
| Thursday, August 27 |
| » Defeated Red Sox (58-69), 5-1 | Comiskey Park I (40-25) | 76-49 | |
| » Starters: Frank Baumann vs Barry Latman | First | -- |
| Friday, August 28 |
| » Defeated Indians (75-52), 7-3 | Cleveland Stadium (5-2) | 77-49 | Won 2 |
| » Starters: Bob Shaw vs Jack Harshman | First | -- |
| Saturday, August 29 |
| » Defeated Indians (75-53), 2-0 | Cleveland Stadium (6-2) | 78-49 | Won 3 |
| » Starters: Dick Donovan vs Jim Perry | First | -- |
| Sunday, August 30 |
| » Defeated Indians (75-54), 6-3 | Cleveland Stadium (7-2) | 79-49 | Won 4 |
| » Starters: Early Wynn vs Cal McLish | First | -- |
| » Defeated Indians (75-55), 9-4 | Cleveland Stadium (8-2) | 80-49 | Won 5 |
| » Starters: Barry Latman vs Gary Bell | First | -- |
| Tuesday, September 1 |
| » Lost to Tigers (66-65), 4-0 | Comiskey Park I (40-26) | 80-50 | |
| » Starters: Jim Bunning vs Bob Shaw | First | -- |
| Wednesday, September 2 |
| » Defeated Tigers (66-66), 7-2 | Comiskey Park I (41-26) | 81-50 | |
| » Starters: Frank Lary vs Dick Donovan | First | -- |
| » Defeated Tigers (66-67), 11-4 | Comiskey Park I (42-26) | 82-50 | Won 2 |
| » Starters: Paul Foytack vs Barry Latman | First | -- |
| » Major-league debuts: Joe Stanka (White Sox) |
| Friday, September 4 |
| » Defeated Indians (76-56), 3-2 | Comiskey Park I (43-26) | 83-50 | Won 3 |
| » Starters: Jim Perry vs Early Wynn | First | -- |
| Saturday, September 5 |
| » Lost to Indians (77-56), 6-5 | Comiskey Park I (43-27) | 83-51 | |
| » Starters: Cal McLish vs Bob Shaw | First | -- |
| Sunday, September 6 |
| » Lost to Indians (78-56), 2-1 | Comiskey Park I (43-28) | 83-52 | Lost 2 |
| » Starters: Mudcat Grant vs Dick Donovan | First | -- |
| Monday, September 7 |
| » Defeated Athletics (59-75), 2-1 | Comiskey Park I (44-28) | 84-52 | |
| » Starters: Ned Garver vs Billy Pierce | First | -- |
| » Defeated Athletics (59-76), 13-7 | Comiskey Park I (45-28) | 85-52 | Won 2 |
| » Starters: John Tsitouris vs Barry Latman | First | -- |
| » Major-league debuts: Evans Killeen (Athletics) |
| Tuesday, September 8 |
| » Defeated Athletics (59-77), 3-2 | Comiskey Park I (46-28) | 86-52 | Won 3 |
| » Starters: Bud Daley vs Early Wynn | First | -- |
| Former White Sox Roy Mitchell dies in Temple, TX at the age of 75. |
| Wednesday, September 9 |
| » Defeated Senators (56-83), 5-1 | Griffith Stadium (8-2) | 87-52 | Won 4 |
| » Starters: Bob Shaw vs Tex Clevenger | First | -- |
| » Major-league debuts: Dan Dobbek (Senators) |
| Thursday, September 10 |
| » Lost to Senators (57-83), 8-2 | Griffith Stadium (8-3) | 87-53 | |
| » Starters: Dick Donovan vs Camilo Pascual | First | -- |
| » Major-league debuts: J.C. Martin and Gary Peters (White Sox) |
| Friday, September 11 |
| » Lost to Orioles (68-71), 3-0 | Memorial Stadium (4-5) | 87-54 | Lost 2 |
| » Starters: Billy Pierce vs Jack Fisher | First | -- |
| » Lost to Orioles (69-71), 1-0 | Memorial Stadium (4-6) | 87-55 | Lost 3 |
| » Starters: Barry Latman vs Jerry Walker | First | -- |
| Saturday, September 12 |
| » Defeated Orioles (69-72), 6-1 | Memorial Stadium (5-6) | 88-55 | |
| » Starters: Early Wynn vs Billy O'Dell | First | -- |
| » Major-league debuts: Bob Saverine (Orioles) |
| Sunday, September 13 |
| » Defeated Red Sox (66-77), 3-1 | Fenway Park (7-3) | 89-55 | Won 2 |
| » Starters: Bob Shaw vs Frank Sullivan | First | -- |
| Monday, September 14 |
| » Lost to Red Sox (67-77), 9-3 | Fenway Park (7-4) | 89-56 | |
| » Starters: Dick Donovan vs Bill Monbouquette | First | -- |
| Tuesday, September 15 |
| » Defeated Yankees (73-72), 4-3 | Yankee Stadium (5-5) | 90-56 | |
| » Starters: Billy Pierce vs Ralph Terry | First | -- |
| Wednesday, September 16 |
| » Lost to Yankees (74-72), 3-1 | Yankee Stadium (5-6) | 90-57 | |
| » Starters: Early Wynn vs Jim Coates | First | -- |
| Future White Sox Tim Raines is born in Sanford, FL. |
| Friday, September 18 |
| » Defeated Tigers (72-75), 1-0 | Comiskey Park I (47-28) | 91-57 | |
| » Starters: Jim Bunning vs Bob Shaw | First | -- |
| » Major-league debuts: Joe Hicks (White Sox) |
| Saturday, September 19 |
| » Lost to Tigers (73-75), 5-4 | Comiskey Park I (47-29) | 91-58 | |
| » Starters: Paul Foytack vs Dick Donovan | First | -- |
| Sunday, September 20 |
| » Lost to Tigers (74-75), 5-4 | Comiskey Park I (47-30) |
