| Thursday, January 22 |
| Former Tiger Ken Williams dies in Grants Pass, OR at the age of 69. |
| Saturday, February 14 |
| Future Tiger Alejandro Sanchez is born in San Pedro de Macoris, D.R. |
| Friday, February 20 |
| Future Tiger Bill Gullickson is born in Marshall, MN. |
| Tuesday, February 24 |
| Future Tiger Bryan Kelly is born in Silver Spring, MD. |
| Monday, March 16 |
| Future Tiger Charles Hudson is born in Ennis, TX. |
| Friday, April 10 |
| » Lost to White Sox (1-0), 9-7 | Tiger Stadium (0-1) | 0-1 | |
| » Starters: Billy Pierce vs Jim Bunning | Third | 1 out |
| » Major-league debuts: Rudy Arias (White Sox) |
| Saturday, April 11 |
| » Lost to White Sox (2-0), 5-3 | Tiger Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Early Wynn vs Paul Foytack | Fifth | 2 out |
| Sunday, April 12 |
| » Lost to White Sox (3-0), 5-3 | Tiger Stadium (0-3) | 0-3 | Lost 3 |
| » Starters: Dick Donovan vs Frank Lary | Sixth | 3 out |
| Tuesday, April 14 |
| » Lost to Indians (3-0), 8-1 | Cleveland Stadium (0-1) | 0-4 | Lost 4 |
| » Starters: Jim Bunning vs Herb Score | Seventh | 4 out |
| » Major-league debuts: Jerry Davie (Tigers) |
| Wednesday, April 15 |
| » Lost to Indians (4-0), 2-1 | Cleveland Stadium (0-2) | 0-5 | Lost 5 |
| » Starters: Paul Foytack vs Cal McLish | Eighth | 4½ out |
| Friday, April 17 |
| » Lost to White Sox (5-2), 6-5 | Comiskey Park I (0-1) | 0-6 | Lost 6 |
| » Starters: Frank Lary vs Dick Donovan | Sixth | 5½ out |
| Saturday, April 18 |
| » Defeated White Sox (5-3), 5-2 | Comiskey Park I (1-1) | 1-6 | |
| » Starters: Billy Hoeft vs Ray Moore | Seventh | 5½ out |
| Tuesday, April 21 |
| » Lost to Indians (7-1), 14-1 | Tiger Stadium (0-4) | 1-7 | |
| » Starters: Cal McLish vs Paul Foytack | Seventh | 6 out |
| Wednesday, April 22 |
| » Lost to Indians (8-1), 10-1 | Tiger Stadium (0-5) | 1-8 | Lost 2 |
| » Starters: Gary Bell vs Frank Lary | Eighth | 7 out |
| » Major-league debuts: Gene Leek (Indians) |
| Thursday, April 23 |
| » Lost to Indians (9-1), 10-4 | Tiger Stadium (0-6) | 1-9 | Lost 3 |
| » Starters: Jim Perry vs Ray Narleski | Seventh | 8 out |
| » Major-league debuts: Jim Perry (Indians) |
| Friday, April 24 |
| » Lost to Athletics (5-6), 10-1 | Municipal Stadium (0-1) | 1-10 | Lost 4 |
| » Starters: Billy Hoeft vs Ralph Terry | Sixth | 9 out |
| Saturday, April 25 |
| » Lost to Athletics (6-6), 8-7 | Municipal Stadium (0-2) | 1-11 | Lost 5 |
| » Starters: Paul Foytack vs Ned Garver | Sixth | 9 out |
| Sunday, April 26 |
| » Lost to Athletics (7-6), 4-3 | Municipal Stadium (0-3) | 1-12 | Lost 6 |
| » Starters: Jim Bunning vs Bob Grim | Sixth | 8½ out |
| Wednesday, April 29 |
| » Defeated Orioles (9-6), 7-1 | Tiger Stadium (1-6) | 2-12 | |
| » Starters: Arnie Portocarrero vs Frank Lary | Seventh | 8 out |
| Thursday, April 30 |
| » Lost to Senators (8-9), 9-1 | Tiger Stadium (1-7) | 2-13 | |
| » Starters: Bill Fischer vs Paul Foytack | Seventh | 8½ out |
| Friday, May 1 |
| » Lost to Senators (9-9), 4-3 | Tiger Stadium (1-8) | 2-14 | Lost 2 |
| » Starters: Camilo Pascual vs Jim Bunning | Eighth | 9½ out |
| Saturday, May 2 |
| » Lost to Senators (10-9), 15-3 | Tiger Stadium (1-9) | 2-15 | Lost 3 |
| » Starters: Russ Kemmerer vs Jerry Davie | Seventh | 10½ out |
| Sunday, May 3 |
| » Defeated Yankees (7-11), 4-2 | Tiger Stadium (2-9) | 3-15 | |
| » Manager: Jimmy Dykes |
| » Starters: Bob Turley vs Frank Lary | Sixth | 9½ out |
| » Defeated Yankees (7-12), 8-2 | Tiger Stadium (3-9) | 4-15 | Won 2 |
| » Starters: Duke Maas vs Don Mossi | Sixth | 9½ out |
| Tuesday, May 5 |
| » Defeated Red Sox (8-10), 8-3 | Tiger Stadium (4-9) | 5-15 | Won 3 |
| » Starters: Jerry Casale vs Jim Bunning | Seventh | 9½ out |
| Wednesday, May 6 |
| » Lost to Red Sox (9-10), 17-6 | Tiger Stadium (4-10) | 5-16 | |
| » Starters: Tom Brewer vs Paul Foytack | Eighth | 9½ out |
| Thursday, May 7 |
| » Defeated Red Sox (9-11), 3-1 | Tiger Stadium (5-10) | 6-16 | |
| » Starters: Ike Delock vs Frank Lary | Eighth | 9 out |
| Friday, May 8 |
| » Defeated Athletics (11-12), 5-4 | Tiger Stadium (6-10) | 7-16 | Won 2 |
| » Starters: Ray Herbert vs Don Mossi | Eighth | 9 out |
| Saturday, May 9 |
| » Defeated Athletics (11-13), 7-4 | Tiger Stadium (7-10) | 8-16 | Won 3 |
| » Starters: Bob Grim vs Jim Bunning | Eighth | 8 out |
| Sunday, May 10 |
| » Defeated Athletics (11-14), 7-6 | Tiger Stadium (8-10) | 9-16 | Won 4 |
| » Starters: Ralph Terry vs Paul Foytack | Eighth | 6½ out |
| Tuesday, May 12 |
| » Lost to Senators (15-14), 7-4 | Griffith Stadium (0-1) | 9-17 | |
| » Starters: Frank Lary vs Bill Fischer | Seventh | 7½ out |
| Thursday, May 14 |
| » Defeated Senators (15-15), 4-2 | Griffith Stadium (1-1) | 10-17 | |
| » Starters: Jim Bunning vs Hal Griggs | Eighth | 7 out |
| Friday, May 15 |
| » Lost to Orioles (16-13), 2-1 | Memorial Stadium (0-1) | 10-18 | |
| » Starters: Don Mossi vs Jerry Walker | Eighth | 8 out |
| Saturday, May 16 |
| » Lost to Orioles (17-13), 6-1 | Memorial Stadium (0-2) | 10-19 | Lost 2 |
| » Starters: Frank Lary vs Hoyt Wilhelm | Eighth | 9 out |
| Sunday, May 17 |
| » Lost to Red Sox (13-17), 10-1 | Fenway Park (0-1) | 10-20 | Lost 3 |
| » Starters: Paul Foytack vs Ike Delock | Eighth | 9½ out |
| Monday, May 18 |
| » Defeated Red Sox (13-18), 14-2 | Fenway Park (1-1) | 11-20 | |
| » Starters: Jim Bunning vs Frank Sullivan | Eighth | 9 out |
| Tuesday, May 19 |
| » Defeated Yankees (12-18), 6-3 | Yankee Stadium (1-0) | 12-20 | Won 2 |
| » Starters: Don Mossi vs Whitey Ford | Eighth | 8½ out |
| Wednesday, May 20 |
| » Defeated Yankees (12-19), 13-6 | Yankee Stadium (2-0) | 13-20 | Won 3 |
| » Starters: Frank Lary vs Bobby Shantz | Seventh | 8½ out |
| Friday, May 22 |
| » Lost to Indians (22-11), 1-0 | Cleveland Stadium (0-3) | 13-21 | |
| » Starters: Paul Foytack vs Gary Bell | Seventh | 9½ out |
| Saturday, May 23 |
| » Defeated Indians (22-12), 6-4 | Cleveland Stadium (1-3) | 14-21 | |
| » Starters: Jim Bunning vs Cal McLish | Seventh | 8½ out |
| Sunday, May 24 |
| » Lost to Indians (23-12), 3-2 | Cleveland Stadium (1-4) | 14-22 | |
| » Starters: Don Mossi vs Herb Score | Seventh | 8½ out |
| » Defeated Indians (23-13), 6-3 | Cleveland Stadium (2-4) | 15-22 | |
| » Starters: Frank Lary vs Mike Garcia | Seventh | 8½ out |
| Monday, May 25 |
| » Defeated Athletics (17-19), 4-3 | Municipal Stadium (1-3) | 16-22 | Won 2 |
| » Starters: Jerry Davie vs Rip Coleman | Sixth | 8 out |
| Tuesday, May 26 |
| » Defeated Athletics (17-20), 9-5 | Municipal Stadium (2-3) | 17-22 | Won 3 |
| » Starters: Paul Foytack vs Ned Garver | Sixth | 8 out |
| Wednesday, May 27 |
| Future Tiger Ron Tingley is born in Presque Isle, ME. |
| Friday, May 29 |
| » Defeated White Sox (24-17), 4-1 | Comiskey Park I (2-1) | 18-22 | Won 4 |
| » Starters: Don Mossi vs Bob Shaw | Sixth | 6½ out |
| Saturday, May 30 |
| » Defeated White Sox (24-18), 4-2 | Comiskey Park I (3-1) | 19-22 | Won 5 |
| » Starters: Frank Lary vs Billy Pierce | Sixth | 6½ out |
| » Lost to White Sox (25-18), 4-3 | Comiskey Park I (3-2) | 19-23 | |
| » Starters: Jim Bunning vs Dick Donovan | Sixth | 6½ out |
| Sunday, May 31 |
| » Defeated Indians (25-17), 7-4 | Tiger Stadium (9-10) | 20-23 | |
| » Starters: Don Ferrarese vs Jerry Davie | Fifth | 5½ out |
| Monday, June 1 |
| » Defeated Indians (25-18), 3-1 | Tiger Stadium (10-10) | 21-23 | Won 2 |
| » Starters: Gary Bell vs Paul Foytack | Fifth | 4½ out |
| Tuesday, June 2 |
| » Defeated Yankees (19-24), 2-0 | Tiger Stadium (11-10) | 22-23 | Won 3 |
| » Starters: Duke Maas vs Don Mossi | Fifth | 3½ out |
| Wednesday, June 3 |
| » Lost to Yankees (20-24), 6-5 | Tiger Stadium (11-11) | 22-24 | |
| » Starters: Ralph Terry vs Frank Lary | Fifth | 3½ out |
| Thursday, June 4 |
| » Lost to Yankees (21-24), 14-3 | Tiger Stadium (11-12) | 22-25 | Lost 2 |
| » Starters: Whitey Ford vs Jim Bunning | Sixth | 4½ out |
| Friday, June 5 |
| » Defeated Senators (23-27), 7-6 | Tiger Stadium (12-12) | 23-25 | |
| » Starters: Camilo Pascual vs Jerry Davie | Fifth | 4½ out |
| Saturday, June 6 |
| » Defeated Senators (23-28), 4-1 | Tiger Stadium (13-12) | 24-25 | Won 2 |
| » Starters: Russ Kemmerer vs Paul Foytack | Fifth | 3½ out |
| Sunday, June 7 |
| » Defeated Senators (23-29), 6-4 | Tiger Stadium (14-12) | 25-25 | Won 3 |
| » Starters: Pedro Ramos vs Don Mossi | Fifth | 3 out |
| Monday, June 8 |
| » Defeated Red Sox (22-29), 6-3 | Fenway Park (2-1) | 26-25 | Won 4 |
| » Starters: Jim Bunning vs Tom Brewer | Fourth | 2½ out |
| Tuesday, June 9 |
| » Lost to Red Sox (23-29), 5-2 | Fenway Park (2-2) | 26-26 | |
| » Starters: Jerry Davie vs Jerry Casale | Fourth | 2½ out |
| Former Tiger Frank Huelsman dies in Affton, MO at the age of 86. |
| Wednesday, June 10 |
| » Defeated Red Sox (23-30), 10-9 | Fenway Park (3-2) | 27-26 | |
| » Starters: Paul Foytack vs Ike Delock | Fifth | 2½ out |
| Thursday, June 11 |
| » Defeated Red Sox (23-31), 8-1 | Fenway Park (4-2) | 28-26 | Won 2 |
| » Starters: Ray Narleski vs Ted Wills | Fourth | 2½ out |
| Friday, June 12 |
| » Defeated Yankees (26-27), 3-1 | Yankee Stadium (3-0) | 29-26 | Won 3 |
| » Starters: Don Mossi vs Jim Bronstad | Third | 2 out |
| Saturday, June 13 |
| » Lost to Yankees (27-27), 6-4 | Yankee Stadium (3-1) | 29-27 | |
| » Starters: Jim Bunning vs Don Larsen | Fourth | 2 out |
| Sunday, June 14 |
| » Defeated Yankees (27-28), 3-2 | Yankee Stadium (4-1) | 30-27 | |
| » Starters: Frank Lary vs Whitey Ford | Third | 2 out |
| » Defeated Yankees (27-29), 8-2 | Yankee Stadium (5-1) | 31-27 | Won 2 |
| » Starters: Paul Foytack vs Duke Maas | Third | 2 out |
| Monday, June 15 |
| » Defeated Orioles (30-29), 6-4 | Memorial Stadium (1-2) | 32-27 | Won 3 |
| » Starters: Ray Narleski vs Hoyt Wilhelm | Third | 1½ out |
| Wednesday, June 17 |
| » Lost to Orioles (31-29), 4-0 | Memorial Stadium (1-3) | 32-28 | |
| » Starters: Jim Bunning vs Milt Pappas | Third | 2½ out |
| Thursday, June 18 |
| » Lost to Orioles (32-29), 7-6 | Memorial Stadium (1-4) | 32-29 | Lost 2 |
| » Starters: Don Mossi vs Jerry Walker | Third | 2½ out |
| Friday, June 19 |
| » Defeated Senators (27-35), 6-4 | Griffith Stadium (2-1) | 33-29 | |
| » Starters: Paul Foytack vs Russ Kemmerer | Fourth | 1½ out |
| Saturday, June 20 |
| » Defeated Senators (27-36), 7-4 | Griffith Stadium (3-1) | 34-29 | Won 2 |
| » Starters: Frank Lary vs Hal Griggs | Second | 1½ out |
| Sunday, June 21 |
| » Lost to Senators (28-36), 4-3 | Griffith Stadium (3-2) | 34-30 | |
| » Starters: Jim Bunning vs Camilo Pascual | Third | 2½ out |
| » Lost to Senators (29-36), 7-5 | Griffith Stadium (3-3) | 34-31 | Lost 2 |
| » Starters: Ray Narleski vs Pedro Ramos | Third | 2½ out |
| Monday, June 22 |
| » Major-league debuts: Eddie Fisher (Giants) |
| Tuesday, June 23 |
| » Lost to Red Sox (29-35), 10-4 | Tiger Stadium (14-13) | 34-32 | Lost 3 |
| » Starters: Ike Delock vs Paul Foytack | Fifth | 2½ out |
| Wednesday, June 24 |
| » Lost to Red Sox (30-35), 4-2 | Tiger Stadium (14-14) | 34-33 | Lost 4 |
| » Starters: Jack Harshman vs Don Mossi | Fifth | 2½ out |
| Thursday, June 25 |
| » Defeated Red Sox (30-36), 10-5 | Tiger Stadium (15-14) | 35-33 | |
| » Starters: Tom Brewer vs Jim Bunning | Fifth | 2½ out |
| Friday, June 26 |
| » Lost to Orioles (37-32), 12-7 | Tiger Stadium (15-15) | 35-34 | |
| » Starters: Billy O'Dell vs Ray Narleski | Fourth | 4 out |
| » Lost to Orioles (38-32), 4-1 | Tiger Stadium (15-16) | 35-35 | Lost 2 |
| » Starters: Jerry Walker vs Frank Lary | Fourth | 4 out |
| Saturday, June 27 |
| » Defeated Orioles (38-33), 12-2 | Tiger Stadium (16-16) | 36-35 | |
| » Starters: Billy Hoeft vs Paul Foytack | Fifth | 3 out |
| Sunday, June 28 |
| » Defeated Orioles (38-34), 7-2 | Tiger Stadium (17-16) | 37-35 | Won 2 |
| » Starters: Milt Pappas vs Don Mossi | Fourth | 3½ out |
| Former Tiger Joe Sugden dies in Philadelphia, PA at the age of 89. |
| Monday, June 29 |
| » Lost to Athletics (31-38), 10-3 | Tiger Stadium (17-17) | 37-36 | |
| » Starters: Bud Daley vs Jim Bunning | Fourth | 4 out |
| Tuesday, June 30 |
| » Defeated Athletics (31-39), 4-0 | Tiger Stadium (18-17) | 38-36 | |
| » Starters: Rip Coleman vs Frank Lary | Fourth | 4 out |
| Wednesday, July 1 |
| » Defeated Athletics (31-40), 5-4 | Tiger Stadium (19-17) | 39-36 | Won 2 |
| » Starters: Ned Garver vs Paul Foytack | Fourth | 3 out |
| Thursday, July 2 |
| » Defeated White Sox (40-34), 9-7 | Tiger Stadium (20-17) | 40-36 | Won 3 |
| » Starters: Bob Shaw vs Don Mossi | Third | 2 out |
| Friday, July 3 |
| » Lost to White Sox (41-34), 6-5 | Tiger Stadium (20-18) | 40-37 | |
| » Starters: Early Wynn vs Jim Bunning | Fifth | 3 out |
| Saturday, July 4 |
| » Lost to Indians (42-32), 6-1 | Tiger Stadium (20-19) | 40-38 | Lost 2 |
| » Starters: Cal McLish vs Frank Lary | Fifth | 5 out |
| » Lost to Indians (43-32), 12-9 | Tiger Stadium (20-20) | 40-39 | Lost 3 |
| » Starters: Bobby Locke vs Ray Narleski | Fifth | 5 out |
| Sunday, July 5 |
| » Lost to Indians (44-32), 5-4 | Tiger Stadium (20-21) | 40-40 | Lost 4 |
| » Starters: Mike Garcia vs Paul Foytack | Fifth | 6 out |
| Thursday, July 9 |
| » Lost to Athletics (34-43), 5-0 | Municipal Stadium (2-4) | 40-41 | Lost 5 |
| » Starters: Frank Lary vs Ray Herbert | Fifth | 6½ out |
| » Lost to Athletics (35-43), 4-0 | Municipal Stadium (2-5) | 40-42 | Lost 6 |
| » Starters: Ray Narleski vs Johnny Kucks | Fifth | 6½ out |
| Friday, July 10 |
| » Defeated Athletics (35-44), 5-2 | Municipal Stadium (3-5) | 41-42 | |
| » Starters: Jim Bunning vs Howie Reed | Fifth | 6½ out |
| Saturday, July 11 |
| » Lost to Indians (46-33), 8-7 | Cleveland Stadium (2-5) | 41-43 | |
| » Starters: Don Mossi vs Mike Garcia | Fifth | 7½ out |
| Sunday, July 12 |
| » Defeated Indians (46-34), 6-2 | Cleveland Stadium (3-5) | 42-43 | |
| » Starters: Paul Foytack vs Bobby Locke | Fifth | 7½ out |
| » Lost to Indians (47-34), 8-4 | Cleveland Stadium (3-6) | 42-44 | |
| » Starters: Tom Morgan vs Al Cicotte | Fifth | 7½ out |
| Tuesday, July 14 |
| » Lost to Senators (40-44), 4-2 | Griffith Stadium (3-4) | 42-45 | Lost 2 |
| » Starters: Frank Lary vs Pedro Ramos | Fifth | 7½ out |
| Wednesday, July 15 |
| » Lost to Senators (41-44), 3-0 | Griffith Stadium (3-5) | 42-46 | Lost 3 |
| » Starters: Jim Bunning vs Camilo Pascual | Sixth | 8 out |
| Thursday, July 16 |
| » Lost to Senators (42-44), 5-2 | Griffith Stadium (3-6) | 42-47 | Lost 4 |
| » Starters: Ray Narleski vs Bill Fischer | Sixth | 8½ out |
| Friday, July 17 |
| » Lost to Orioles (46-42), 3-2 | Memorial Stadium (1-5) | 42-48 | Lost 5 |
| » Starters: Don Mossi vs Hal Brown | Sixth | 9½ out |
| Saturday, July 18 |
| » Lost to Orioles (47-42), 5-2 | Memorial Stadium (1-6) | 42-49 | Lost 6 |
| » Starters: Paul Foytack vs Arnie Portocarrero | Sixth | 10 out |
| » Defeated Orioles (47-43), 2-0 | Memorial Stadium (2-6) | 43-49 | |
| » Starters: Frank Lary vs Hoyt Wilhelm | Sixth | 10 out |
| Sunday, July 19 |
| » Lost to Orioles (48-43), 2-1 | Memorial Stadium (2-7) | 43-50 | |
| » Starters: Jim Bunning vs Billy O'Dell | Sixth | 9½ out |
| Tuesday, July 21 |
| » Defeated Senators (43-48), 8-1 | Tiger Stadium (21-21) | 44-50 | |
| » Starters: Bill Fischer vs Paul Foytack | Sixth | 9½ out |
| Wednesday, July 22 |
| » Defeated Senators (43-49), 6-2 | Tiger Stadium (22-21) | 45-50 | Won 2 |
| » Starters: Pedro Ramos vs Frank Lary | Fifth | 9½ out |
| Thursday, July 23 |
| » Defeated Senators (43-50), 11-2 | Tiger Stadium (23-21) | 46-50 | Won 3 |
| » Starters: Hal Woodeshick vs Jim Bunning | Fifth | 9 out |
| Friday, July 24 |
| » Defeated Yankees (47-48), 4-2 | Tiger Stadium (24-21) | 47-50 | Won 4 |
| » Starters: Don Larsen vs Don Mossi | Fifth | 9 out |
| Saturday, July 25 |
| » Lost to Yankees (48-48), 9-8 | Tiger Stadium (24-22) | 47-51 | |
| » Starters: Whitey Ford vs Paul Foytack | Fourth | 10 out |
| Sunday, July 26 |
| » Defeated Yankees (48-49), 1-0 | Tiger Stadium (25-22) | 48-51 | |
| » Starters: Art Ditmar vs Frank Lary | Fifth | 10 out |
| Monday, July 27 |
| » Lost to Orioles (50-49), 5-2 | Tiger Stadium (25-23) | 48-52 | |
| » Starters: Hal Brown vs Jim Bunning | Fifth | 10 out |
| » Major-league debuts: Barry Shetrone (Orioles) |
| Tuesday, July 28 |
| » Defeated Orioles (50-50), 8-3 | Tiger Stadium (26-23) | 49-52 | |
| » Starters: Hoyt Wilhelm vs Don Mossi | Sixth | 10 out |
| Wednesday, July 29 |
| » Lost to Orioles (51-50), 5-1 | Tiger Stadium (26-24) | 49-53 | |
| » Starters: Jerry Walker vs Paul Foytack | Sixth | 10½ out |
| » Major-league debuts: Steve Demeter (Tigers) |
| Future Tiger Dave LaPoint is born in Glens Falls, NY. |
| Thursday, July 30 |
| » Defeated Orioles (51-51), 11-2 | Tiger Stadium (27-24) | 50-53 | |
| » Starters: Billy O'Dell vs Frank Lary | Sixth | 10½ out |
| Friday, July 31 |
| » Lost to Red Sox (44-57), 6-5 | Tiger Stadium (27-25) | 50-54 | |
| » Starters: Earl Wilson vs Jim Bunning | Sixth | 11½ out |
| Saturday, August 1 |
| » Defeated Red Sox (44-58), 6-2 | Tiger Stadium (28-25) | 51-54 | |
| » Starters: Jerry Casale vs Don Mossi | Fifth | 11½ out |
| Sunday, August 2 |
| » Lost to Red Sox (45-58), 5-4 | Tiger Stadium (28-26) | 51-55 | |
| » Starters: Bill Monbouquette vs Paul Foytack | Sixth | 13 out |
| Tuesday, August 4 |
| » Defeated Yankees (50-53), 4-3 | Yankee Stadium (6-1) | 52-55 | |
| » Starters: Frank Lary vs Eli Grba | Fifth | 12 out |
| Wednesday, August 5 |
| » Lost to Yankees (51-53), 3-0 | Yankee Stadium (6-2) | 52-56 | |
| » Starters: Don Mossi vs Bobby Shantz | Sixth | 12½ out |
| Thursday, August 6 |
| » Defeated Yankees (51-54), 4-0 | Yankee Stadium (7-2) | 53-56 | |
| » Starters: Paul Foytack vs Art Ditmar | Sixth | 12 out |
| Friday, August 7 |
| » Lost to Red Sox (49-59), 4-3 | Fenway Park (4-3) | 53-57 | |
| » Starters: Jim Bunning vs Bill Monbouquette | Sixth | 13 out |
| Saturday, August 8 |
| » Lost to Red Sox (50-59), 4-3 | Fenway Park (4-4) | 53-58 | Lost 2 |
| » Starters: Frank Lary vs Al Schroll | Sixth | 13½ out |
| Sunday, August 9 |
| » Defeated Red Sox (50-60), 7-3 | Fenway Park (5-4) | 54-58 | |
| » Starters: Don Mossi vs Tom Brewer | Fifth | 14 out |
| Tuesday, August 11 |
| » Defeated White Sox (66-43), 8-1 | Tiger Stadium (29-26) | 55-58 | Won 2 |
| » Starters: Billy Pierce vs Jim Bunning | Fifth | 13 out |
| Wednesday, August 12 |
| » Lost to White Sox (67-43), 11-6 | Tiger Stadium (29-27) | 55-59 | |
| » Starters: Barry Latman vs Paul Foytack | Fifth | 14 out |
| Thursday, August 13 |
| » Lost to White Sox (68-43), 9-0 | Tiger Stadium (29-28) | 55-60 | Lost 2 |
| » Starters: Early Wynn vs Don Mossi | Fifth | 15 out |
| Friday, August 14 |
| » Defeated Indians (67-48), 11-1 | Tiger Stadium (30-28) | 56-60 | |
| » Starters: Cal McLish vs Frank Lary | Fifth | 15 out |
| Saturday, August 15 |
| » Defeated Indians (67-49), 9-6 | Tiger Stadium (31-28) | 57-60 | Won 2 |
| » Starters: Herb Score vs Jim Bunning | Fifth | 14 out |
| Monday, August 17 |
| » Defeated Indians (67-50), 5-4 | Tiger Stadium (32-28) | 58-60 | Won 3 |
| » Starters: Gary Bell vs Paul Foytack | Fifth | 13 out |
| Tuesday, August 18 |
| » Lost to Yankees (59-59), 5-3 | Tiger Stadium (32-29) | 58-61 | |
| » Starters: Art Ditmar vs Don Mossi | Fifth | 14 out |
| Wednesday, August 19 |
| » Lost to Yankees (60-59), 10-5 | Tiger Stadium (32-30) | 58-62 | Lost 2 |
| » Starters: Eli Grba vs Frank Lary | Fifth | 14 out |
| Thursday, August 20 |
| » Defeated Yankees (60-60), 14-2 | Tiger Stadium (33-30) | 59-62 | |
| » Starters: Gary Blaylock vs Jim Bunning | Fifth | 13 out |
| Friday, August 21 |
| » Defeated Red Sox (56-65), 2-0 | Tiger Stadium (34-30) | 60-62 | Won 2 |
| » Starters: Bill Monbouquette vs Paul Foytack | Fifth | 13 out |
| Saturday, August 22 |
| » Lost to Red Sox (57-65), 7-1 | Tiger Stadium (34-31) | 60-63 | |
| » Starters: Frank Baumann vs Don Mossi | Fifth | 14 out |
| » Major-league debuts: Ron Shoop (Tigers) |
| Sunday, August 23 |
| » Defeated Orioles (59-62), 9-5 | Tiger Stadium (35-31) | 61-63 | |
| » Starters: Arnie Portocarrero vs Frank Lary | Fourth | 13½ out |
| Monday, August 24 |
| » Lost to Orioles (60-62), 11-0 | Tiger Stadium (35-32) | 61-64 | |
| » Starters: Hoyt Wilhelm vs Don Mossi | Fifth | 14½ out |
| Tuesday, August 25 |
| » Lost to Senators (51-74), 3-1 | Tiger Stadium (35-33) | 61-65 | Lost 2 |
| » Starters: Pedro Ramos vs Paul Foytack | Fifth | 15½ out |
| Wednesday, August 26 |
| » Defeated Senators (51-75), 3-2 | Tiger Stadium (36-33) | 62-65 | |
| » Starters: Russ Kemmerer vs Jim Bunning | Fourth | 14½ out |
| Friday, August 28 |
| » Defeated Athletics (59-68), 6-5 | Municipal Stadium (4-5) | 63-65 | Won 2 |
| » Starters: Frank Lary vs Johnny Kucks | Third | 15 out |
| Saturday, August 29 |
| » Defeated Athletics (59-69), 9-3 | Municipal Stadium (5-5) | 64-65 | Won 3 |
| » Starters: Paul Foytack vs Ray Herbert | Third | 15 out |
| Sunday, August 30 |
| » Defeated Athletics (59-70), 4-0 | Municipal Stadium (6-5) | 65-65 | Won 4 |
| » Starters: Don Mossi vs Bud Daley | Third | 15½ out |
| Tuesday, September 1 |
| » Defeated White Sox (80-50), 4-0 | Comiskey Park I (4-2) | 66-65 | Won 5 |
| » Starters: Jim Bunning vs Bob Shaw | Third | 14½ out |
| Wednesday, September 2 |
| » Lost to White Sox (81-50), 7-2 | Comiskey Park I (4-3) | 66-66 | |
| » Starters: Frank Lary vs Dick Donovan | Fourth | 16½ out |
| » Lost to White Sox (82-50), 11-4 | Comiskey Park I (4-4) | 66-67 | Lost 2 |
| » Starters: Paul Foytack vs Barry Latman | Fourth | 16½ out |
| » Major-league debuts: Joe Stanka (White Sox) |
| Friday, September 4 |
| » Defeated Athletics (59-72), 9-2 | Tiger Stadium (37-33) | 67-67 | |
| » Starters: Bud Daley vs Don Mossi | Third | 16½ out |
| Saturday, September 5 |
| » Defeated Athletics (59-73), 5-4 | Tiger Stadium (38-33) | 68-67 | Won 2 |
| » Starters: Johnny Kucks vs Jim Bunning | Third | 15½ out |
| Sunday, September 6 |
| » Defeated Athletics (59-74), 7-6 | Tiger Stadium (39-33) | 69-67 | Won 3 |
| » Starters: Ray Herbert vs Frank Lary | Third | 14½ out |
| Monday, September 7 |
| » Lost to Indians (79-56), 15-14 | Cleveland Stadium (3-7) | 69-68 | |
| » Starters: Paul Foytack vs Mike Garcia | Third | 16½ out |
| » Lost to Indians (80-56), 6-5 | Cleveland Stadium (3-8) | 69-69 | Lost 2 |
| » Starters: Ray Narleski vs Bob Smith | Third | 16½ out |
| Wednesday, September 9 |
| » Defeated Red Sox (64-75), 3-1 | Fenway Park (6-4) | 70-69 | |
| » Starters: Jim Bunning vs Frank Sullivan | Third | 17 out |
| Thursday, September 10 |
| » Lost to Red Sox (65-75), 7-3 | Fenway Park (6-5) | 70-70 | |
| » Starters: Frank Lary vs Bill Monbouquette | Fourth | 17 out |
| Future Tiger Bruce Robbins is born in Portland, IN. |
| Friday, September 11 |
| » Lost to Yankees (71-69), 9-3 | Yankee Stadium (7-3) | 70-71 | Lost 2 |
| » Starters: Paul Foytack vs Jim Coates | Fourth | 16½ out |
| Saturday, September 12 |
| » Defeated Yankees (71-70), 4-0 | Yankee Stadium (8-3) | 71-71 | |
| » Starters: Don Mossi vs Whitey Ford | Fourth | 16½ out |
| Future Tiger Scotti Madison is born in Pensacola, FL. |
| Sunday, September 13 |
| » Lost to Senators (59-84), 5-1 | Griffith Stadium (3-7) | 71-72 | |
| » Starters: Jim Bunning vs Bill Fischer | Fourth | 17½ out |
| Monday, September 14 |
| » Lost to Senators (60-84), 5-0 | Griffith Stadium (3-8) | 71-73 | Lost 2 |
| » Starters: Ray Narleski vs Tex Clevenger | Fourth | 17½ out |
| » Major-league debuts: Bob Bruce and Jim Proctor (Tigers) |
| Tuesday, September 15 |
| » Lost to Orioles (71-74), 2-1 | Memorial Stadium (2-8) | 71-74 | Lost 3 |
| » Starters: Paul Foytack vs Hoyt Wilhelm | Fourth | 18½ out |
| Wednesday, September 16 |
| » Defeated Orioles (71-75), 3-1 | Memorial Stadium (3-8) | 72-74 | |
| » Starters: Don Mossi vs Jack Fisher | Fourth | 17½ out |
| Friday, September 18 |
| » Lost to White Sox (91-57), 1-0 | Comiskey Park I (4-5) | 72-75 | |
| » Starters: Jim Bunning vs Bob Shaw | Fourth | 18½ out |
| » Major-league debuts: Joe Hicks (White Sox) |
| Saturday, September 19 |
| » Defeated White Sox (91-58), 5-4 | Comiskey Park I (5-5) | 73-75 | |
| » Starters: Paul Foytack vs Dick Donovan | Fourth | 17½ out |
| Sunday, September 20 |
| » Defeated White Sox (91-59), 5-4 | Comiskey Park I (6-5) | 74-75 | Won 2 |
| » Starters: Don Mossi vs Billy Pierce | Fourth | 16½ out |
| Tuesday, September 22 |
| » Defeated Athletics (63-86), 6-4 | Tiger Stadium (40-33) | 75-75 | Won 3 |
| » Starters: Ken Johnson vs Jim Bunning | Fourth | 16½ out |
| Wednesday, September 23 |
| » Lost to Athletics (64-86), 7-6 | Tiger Stadium (40-34) | 75-76 | |
| » Starters: John Tsitouris vs Paul Foytack | Fourth | 17 out |
| Friday, September 25 |
| » Defeated White Sox (92-60), 6-5 | Tiger Stadium (41-34) | 76-76 | |
| » Starters: Billy Pierce vs Don Mossi | Fourth | 16 out |
| Saturday, September 26 |
| » Lost to White Sox (93-60), 10-5 | Tiger Stadium (41-35) | 76-77 | |
| » Starters: Early Wynn vs Jim Proctor | Fourth | 17 out |
| Sunday, September 27 |
| » Lost to White Sox (94-60), 6-4 | Tiger Stadium (41-36) | 76-78 | Lost 2 |
| » Starters: Bob Shaw vs Bob Bruce | Fourth | 18 out |
| » Major-league debuts: |
