| Wednesday, January 28 |
| Former Senator Walter Beall dies in Suitland, MD at the age of 60. |
| Sunday, February 22 |
| Former Senator Hunter Hill dies in Austin, TX at the age of 80. |
| Thursday, April 9 |
| » Defeated Orioles (0-1), 9-2 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Jack Harshman vs Pedro Ramos | First | -- |
| Tuesday, April 14 |
| » Lost to Red Sox (1-1), 7-3 | Fenway Park (0-1) | 1-1 | |
| » Starters: Camilo Pascual vs Ike Delock | Fourth | 2 out |
| Wednesday, April 15 |
| » Lost to Red Sox (2-1), 7-3 | Fenway Park (0-2) | 1-2 | Lost 2 |
| » Starters: Russ Kemmerer vs Jerry Casale | Fifth | 2½ out |
| » Major-league debuts: Jack Kralick (Senators) |
| Thursday, April 16 |
| » Defeated Red Sox (2-2), 7-5 | Fenway Park (1-2) | 2-2 | |
| » Starters: Pedro Ramos vs Herb Moford | Fourth | 2 out |
| Friday, April 17 |
| » Lost to Orioles (2-3), 4-3 | Memorial Stadium (0-1) | 2-3 | |
| » Starters: Bill Fischer vs Milt Pappas | Fourth | 3 out |
| Saturday, April 18 |
| » Lost to Orioles (3-3), 6-1 | Memorial Stadium (0-2) | 2-4 | Lost 2 |
| » Starters: Chuck Stobbs vs Jerry Walker | Fifth | 4 out |
| Sunday, April 19 |
| » Lost to Orioles (4-3), 7-5 | Memorial Stadium (0-3) | 2-5 | Lost 3 |
| » Starters: Camilo Pascual vs Billy O'Dell | Fifth | 3½ out |
| » Defeated Orioles (4-4), 4-2 | Memorial Stadium (1-3) | 3-5 | |
| » Starters: Russ Kemmerer vs Jack Harshman | Fifth | 3½ out |
| » Major-league debuts: Wes Stock (Orioles) |
| Tuesday, April 21 |
| » Lost to Yankees (5-3), 11-4 | Griffith Stadium (1-1) | 3-6 | |
| » Starters: Don Larsen vs Pedro Ramos | Sixth | 4½ out |
| Wednesday, April 22 |
| » Lost to Yankees (6-3), 1-0 | Griffith Stadium (1-2) | 3-7 | Lost 2 |
| » Starters: Whitey Ford vs Bill Fischer | Seventh | 5½ out |
| Thursday, April 23 |
| » Defeated Yankees (6-4), 3-2 | Griffith Stadium (2-2) | 4-7 | |
| » Starters: Bob Turley vs Russ Kemmerer | Sixth | 5½ out |
| Friday, April 24 |
| » Lost to Red Sox (6-5), 7-2 | Griffith Stadium (2-3) | 4-8 | |
| » Starters: Ike Delock vs Vito Valentinetti | Fifth | 6½ out |
| Saturday, April 25 |
| » Defeated Red Sox (6-6), 8-4 | Griffith Stadium (3-3) | 5-8 | |
| » Starters: Herb Moford vs Pedro Ramos | Fifth | 5½ out |
| Sunday, April 26 |
| » Defeated Red Sox (6-7), 2-1 | Griffith Stadium (4-3) | 6-8 | Won 2 |
| » Starters: Jerry Casale vs Bill Fischer | Fifth | 4 out |
| Tuesday, April 28 |
| » Defeated Athletics (7-7), 8-3 | Municipal Stadium (1-0) | 7-8 | Won 3 |
| » Starters: Russ Kemmerer vs Ray Herbert | Fourth | 3½ out |
| Wednesday, April 29 |
| » Lost to Athletics (8-7), 7-6 | Municipal Stadium (1-1) | 7-9 | |
| » Starters: Pedro Ramos vs Ralph Terry | Sixth | 4 out |
| Thursday, April 30 |
| » Defeated Tigers (2-13), 9-1 | Tiger Stadium (1-0) | 8-9 | |
| » Starters: Bill Fischer vs Paul Foytack | Fourth | 3½ out |
| Friday, May 1 |
| » Defeated Tigers (2-14), 4-3 | Tiger Stadium (2-0) | 9-9 | Won 2 |
| » Starters: Camilo Pascual vs Jim Bunning | Fifth | 3½ out |
| Saturday, May 2 |
| » Defeated Tigers (2-15), 15-3 | Tiger Stadium (3-0) | 10-9 | Won 3 |
| » Starters: Russ Kemmerer vs Jerry Davie | Fourth | 3½ out |
| Sunday, May 3 |
| » Lost to Indians (13-4), 5-0 | Cleveland Stadium (0-1) | 10-10 | |
| » Starters: Pedro Ramos vs Mudcat Grant | Third | 3½ out |
| » Defeated Indians (13-5), 3-1 | Cleveland Stadium (1-1) | 11-10 | |
| » Starters: Hal Griggs vs Mike Garcia | Third | 3½ out |
| Tuesday, May 5 |
| » Defeated White Sox (11-9), 8-3 | Comiskey Park I (1-0) | 12-10 | Won 2 |
| » Starters: Chuck Stobbs vs Billy Pierce | Third | 3½ out |
| Wednesday, May 6 |
| » Defeated White Sox (11-10), 6-4 | Comiskey Park I (2-0) | 13-10 | Won 3 |
| » Starters: Camilo Pascual vs Early Wynn | Third | 2½ out |
| Thursday, May 7 |
| » Lost to Orioles (13-9), 10-1 | Griffith Stadium (4-4) | 13-11 | |
| » Starters: Jerry Walker vs Pedro Ramos | Third | 3 out |
| Saturday, May 9 |
| » Defeated Yankees (9-13), 7-0 | Yankee Stadium (1-0) | 14-11 | |
| » Starters: Hal Griggs vs Bob Turley | Third | 2½ out |
| Sunday, May 10 |
| » Lost to Yankees (10-13), 6-3 | Yankee Stadium (1-1) | 14-12 | |
| » Starters: Chuck Stobbs vs Whitey Ford | Fourth | 2½ out |
| » Lost to Yankees (11-13), 3-2 | Yankee Stadium (1-2) | 14-13 | Lost 2 |
| » Starters: Camilo Pascual vs Don Larsen | Fourth | 2½ out |
| Monday, May 11 |
| » Lost to Orioles (15-12), 7-3 | Griffith Stadium (4-5) | 14-14 | Lost 3 |
| » Starters: Milt Pappas vs Pedro Ramos | Fifth | 3 out |
| Tuesday, May 12 |
| » Defeated Tigers (9-17), 7-4 | Griffith Stadium (5-5) | 15-14 | |
| » Starters: Frank Lary vs Bill Fischer | Fourth | 3 out |
| Thursday, May 14 |
| » Lost to Tigers (10-17), 4-2 | Griffith Stadium (5-6) | 15-15 | |
| » Starters: Jim Bunning vs Hal Griggs | Fourth | 3½ out |
| Friday, May 15 |
| » Lost to Athletics (13-14), 4-2 | Griffith Stadium (5-7) | 15-16 | Lost 2 |
| » Starters: Ray Herbert vs Russ Kemmerer | Fourth | 4½ out |
| Saturday, May 16 |
| » Defeated Athletics (13-15), 7-2 | Griffith Stadium (6-7) | 16-16 | |
| » Starters: Ralph Terry vs Camilo Pascual | Fourth | 4½ out |
| Sunday, May 17 |
| » Defeated White Sox (19-12), 4-2 | Griffith Stadium (7-7) | 17-16 | Won 2 |
| » Starters: Dick Donovan vs Pedro Ramos | Fourth | 4½ out |
| » Lost to White Sox (20-12), 10-7 | Griffith Stadium (7-8) | 17-17 | |
| » Starters: Bob Shaw vs Bill Fischer | Fourth | 4½ out |
| Monday, May 18 |
| » Lost to White Sox (21-12), 9-2 | Griffith Stadium (7-9) | 17-18 | Lost 2 |
| » Starters: Early Wynn vs Chuck Stobbs | Fourth | 5 out |
| Tuesday, May 19 |
| » Lost to Indians (20-11), 5-2 | Griffith Stadium (7-10) | 17-19 | Lost 3 |
| » Starters: Mudcat Grant vs Hal Griggs | Fourth | 5½ out |
| Wednesday, May 20 |
| » Lost to Indians (21-11), 5-3 | Griffith Stadium (7-11) | 17-20 | Lost 4 |
| » Starters: Herb Score vs Russ Kemmerer | Fifth | 6½ out |
| Friday, May 22 |
| » Lost to Red Sox (15-19), 4-3 | Fenway Park (1-3) | 17-21 | Lost 5 |
| » Starters: Camilo Pascual vs Ike Delock | Fifth | 7½ out |
| Saturday, May 23 |
| » Defeated Red Sox (15-20), 10-4 | Fenway Park (2-3) | 18-21 | |
| » Starters: Pedro Ramos vs Frank Sullivan | Fifth | 6½ out |
| Sunday, May 24 |
| » Defeated Red Sox (15-21), 8-3 | Fenway Park (3-3) | 19-21 | Won 2 |
| » Starters: Bill Fischer vs Jerry Casale | Fifth | 6 out |
| » Major-league debuts: Ted Wills (Red Sox) |
| Tuesday, May 26 |
| » Lost to Orioles (23-17), 6-5 | Memorial Stadium (1-4) | 19-22 | |
| » Starters: Russ Kemmerer vs Hal Brown | Fourth | 7 out |
| Wednesday, May 27 |
| » Defeated Orioles (23-18), 6-0 | Memorial Stadium (2-4) | 20-22 | |
| » Starters: Camilo Pascual vs Arnie Portocarrero | Fourth | 6 out |
| Thursday, May 28 |
| » Lost to Red Sox (17-22), 3-1 | Griffith Stadium (7-12) | 20-23 | |
| » Starters: Frank Sullivan vs Pedro Ramos | Fifth | 6 out |
| Friday, May 29 |
| » Defeated Red Sox (17-23), 7-6 | Griffith Stadium (8-12) | 21-23 | |
| » Starters: Bill Monbouquette vs Bill Fischer | Fourth | 5½ out |
| Saturday, May 30 |
| » Lost to Yankees (17-23), 11-2 | Griffith Stadium (8-13) | 21-24 | |
| » Starters: Art Ditmar vs Hal Griggs | Fifth | 6½ out |
| » Lost to Yankees (18-23), 11-0 | Griffith Stadium (8-14) | 21-25 | Lost 2 |
| » Starters: Don Larsen vs Russ Kemmerer | Fifth | 6½ out |
| Sunday, May 31 |
| » Lost to Yankees (19-23), 3-0 | Griffith Stadium (8-15) | 21-26 | Lost 3 |
| » Starters: Bob Turley vs Camilo Pascual | Seventh | 6½ out |
| Tuesday, June 2 |
| » Defeated Indians (25-19), 3-2 | Cleveland Stadium (2-1) | 22-26 | |
| » Starters: Pedro Ramos vs Mudcat Grant | Sixth | 5 out |
| Wednesday, June 3 |
| » Defeated Indians (25-20), 4-0 | Cleveland Stadium (3-1) | 23-26 | Won 2 |
| » Starters: Bill Fischer vs Herb Score | Sixth | 4 out |
| Friday, June 5 |
| » Lost to Tigers (23-25), 7-6 | Tiger Stadium (3-1) | 23-27 | |
| » Starters: Camilo Pascual vs Jerry Davie | Seventh | 5½ out |
| Saturday, June 6 |
| » Lost to Tigers (24-25), 4-1 | Tiger Stadium (3-2) | 23-28 | Lost 2 |
| » Starters: Russ Kemmerer vs Paul Foytack | Seventh | 5½ out |
| Sunday, June 7 |
| » Lost to Tigers (25-25), 6-4 | Tiger Stadium (3-3) | 23-29 | Lost 3 |
| » Starters: Pedro Ramos vs Don Mossi | Seventh | 6 out |
| Tuesday, June 9 |
| » Defeated White Sox (29-24), 7-4 | Griffith Stadium (9-15) | 24-29 | |
| » Starters: Bob Shaw vs Bill Fischer | Sixth | 5 out |
| Former Senator Frank Huelsman dies in Affton, MO at the age of 86. |
| Wednesday, June 10 |
| » Lost to White Sox (30-24), 4-1 | Griffith Stadium (9-16) | 24-30 | |
| » Starters: Early Wynn vs Hal Woodeshick | Seventh | 6 out |
| Thursday, June 11 |
| » Lost to White Sox (31-24), 3-1 | Griffith Stadium (9-17) | 24-31 | Lost 2 |
| » Starters: Billy Pierce vs Camilo Pascual | Seventh | 7 out |
| Saturday, June 13 |
| » Lost to Indians (29-24), 8-7 | Griffith Stadium (9-18) | 24-32 | Lost 3 |
| » Starters: Mike Garcia vs Pedro Ramos | Seventh | 7 out |
| Sunday, June 14 |
| » Lost to Indians (30-24), 9-5 | Griffith Stadium (9-19) | 24-33 | Lost 4 |
| » Starters: Mudcat Grant vs Russ Kemmerer | Eighth | 9 out |
| » Lost to Indians (31-24), 12-6 | Griffith Stadium (9-20) | 24-34 | Lost 5 |
| » Starters: Herb Score vs Bill Fischer | Eighth | 9 out |
| Monday, June 15 |
| » Defeated Athletics (26-29), 8-5 | Griffith Stadium (10-20) | 25-34 | |
| » Starters: Bud Daley vs John Romonosky | Eighth | 8½ out |
| Wednesday, June 17 |
| » Defeated Athletics (26-30), 7-2 | Griffith Stadium (11-20) | 26-34 | Won 2 |
| » Starters: Ned Garver vs Camilo Pascual | Seventh | 8½ out |
| Thursday, June 18 |
| » Defeated Athletics (26-31), 7-5 | Griffith Stadium (12-20) | 27-34 | Won 3 |
| » Starters: Ray Herbert vs Bill Fischer | Sixth | 7½ out |
| Friday, June 19 |
| » Lost to Tigers (33-29), 6-4 | Griffith Stadium (12-21) | 27-35 | |
| » Starters: Paul Foytack vs Russ Kemmerer | Seventh | 7½ out |
| Saturday, June 20 |
| » Lost to Tigers (34-29), 7-4 | Griffith Stadium (12-22) | 27-36 | Lost 2 |
| » Starters: Frank Lary vs Hal Griggs | Eighth | 7½ out |
| Sunday, June 21 |
| » Defeated Tigers (34-30), 4-3 | Griffith Stadium (13-22) | 28-36 | |
| » Starters: Jim Bunning vs Camilo Pascual | Sixth | 7½ out |
| » Defeated Tigers (34-31), 7-5 | Griffith Stadium (14-22) | 29-36 | Won 2 |
| » Starters: Ray Narleski vs Pedro Ramos | Sixth | 7½ out |
| Monday, June 22 |
| » Major-league debuts: Eddie Fisher (Giants) |
| Tuesday, June 23 |
| » Lost to White Sox (35-30), 4-1 | Comiskey Park I (2-1) | 29-37 | |
| » Starters: Bill Fischer vs Early Wynn | Eighth | 7½ out |
| Wednesday, June 24 |
| » Defeated White Sox (35-31), 4-2 | Comiskey Park I (3-1) | 30-37 | |
| » Starters: Russ Kemmerer vs Dick Donovan | Eighth | 6½ out |
| Thursday, June 25 |
| » Lost to White Sox (36-31), 4-1 | Comiskey Park I (3-2) | 30-38 | |
| » Starters: Pedro Ramos vs Barry Latman | Eighth | 7½ out |
| Friday, June 26 |
| » Defeated Athletics (29-37), 8-4 | Municipal Stadium (2-1) | 31-38 | |
| » Starters: Camilo Pascual vs Ned Garver | Fifth | 7½ out |
| Saturday, June 27 |
| » Lost to Athletics (30-37), 5-4 | Municipal Stadium (2-2) | 31-39 | |
| » Starters: Bill Fischer vs Ray Herbert | Eighth | 7½ out |
| Sunday, June 28 |
| » Defeated Athletics (30-38), 7-3 | Municipal Stadium (3-2) | 32-39 | |
| » Starters: Russ Kemmerer vs Howie Reed | Sixth | 8 out |
| Tuesday, June 30 |
| » Defeated Red Sox (31-40), 6-1 | Griffith Stadium (15-22) | 33-39 | Won 2 |
| » Starters: Tom Brewer vs Pedro Ramos | Sixth | 8 out |
| Wednesday, July 1 |
| » Defeated Red Sox (31-41), 4-1 | Griffith Stadium (16-22) | 34-39 | Won 3 |
| » Starters: Jerry Casale vs Camilo Pascual | Sixth | 7 out |
| Thursday, July 2 |
| » Defeated Red Sox (31-42), 6-3 | Griffith Stadium (17-22) | 35-39 | Won 4 |
| » Starters: Frank Sullivan vs Bill Fischer | Sixth | 6 out |
| Friday, July 3 |
| » Lost to Yankees (39-36), 4-3 | Yankee Stadium (1-3) | 35-40 | |
| » Starters: Russ Kemmerer vs Whitey Ford | Sixth | 7 out |
| Former Senator Red Barnes dies in Mobile, AL at the age of 55. |
| Saturday, July 4 |
| » Defeated Yankees (39-37), 10-6 | Yankee Stadium (2-3) | 36-40 | |
| » Starters: Pedro Ramos vs Art Ditmar | Sixth | 8 out |
| » Lost to Yankees (40-37), 7-0 | Yankee Stadium (2-4) | 36-41 | |
| » Starters: Hal Griggs vs Bob Turley | Sixth | 8 out |
| Sunday, July 5 |
| » Defeated Yankees (40-38), 7-0 | Yankee Stadium (3-4) | 37-41 | |
| » Starters: Camilo Pascual vs Duke Maas | Sixth | 8 out |
| Thursday, July 9 |
| » Lost to Orioles (42-38), 8-0 | Griffith Stadium (17-23) | 37-42 | |
| » Starters: Milt Pappas vs Russ Kemmerer | Sixth | 8½ out |
| » Lost to Orioles (43-38), 5-0 | Griffith Stadium (17-24) | 37-43 | Lost 2 |
| » Starters: Jerry Walker vs Pedro Ramos | Sixth | 8½ out |
| Friday, July 10 |
| » Defeated Orioles (43-39), 7-6 | Griffith Stadium (18-24) | 38-43 | |
| » Starters: Jack Fisher vs Camilo Pascual | Sixth | 8½ out |
| Saturday, July 11 |
| » Defeated Orioles (43-40), 9-3 | Griffith Stadium (19-24) | 39-43 | Won 2 |
| » Starters: Hal Brown vs Bill Fischer | Sixth | 8½ out |
| Sunday, July 12 |
| » Lost to Orioles (44-40), 5-1 | Griffith Stadium (19-25) | 39-44 | |
| » Starters: Hoyt Wilhelm vs Russ Kemmerer | Sixth | 9 out |
| Tuesday, July 14 |
| » Defeated Tigers (42-45), 4-2 | Griffith Stadium (20-25) | 40-44 | |
| » Starters: Frank Lary vs Pedro Ramos | Sixth | 8 out |
| Wednesday, July 15 |
| » Defeated Tigers (42-46), 3-0 | Griffith Stadium (21-25) | 41-44 | Won 2 |
| » Starters: Jim Bunning vs Camilo Pascual | Fifth | 7½ out |
| Thursday, July 16 |
| » Defeated Tigers (42-47), 5-2 | Griffith Stadium (22-25) | 42-44 | Won 3 |
| » Starters: Ray Narleski vs Bill Fischer | Fifth | 7 out |
| Friday, July 17 |
| » Lost to Athletics (38-48), 7-4 | Griffith Stadium (22-26) | 42-45 | |
| » Starters: Ned Garver vs Russ Kemmerer | Fifth | 8 out |
| Saturday, July 18 |
| » Lost to Athletics (39-48), 10-3 | Griffith Stadium (22-27) | 42-46 | Lost 2 |
| » Starters: Ray Herbert vs Pedro Ramos | Fifth | 9 out |
| Sunday, July 19 |
| » Defeated Athletics (39-49), 7-0 | Griffith Stadium (23-27) | 43-46 | |
| » Starters: Johnny Kucks vs Camilo Pascual | Fifth | 8 out |
| » Lost to Athletics (40-49), 6-5 | Griffith Stadium (23-28) | 43-47 | |
| » Starters: Tom Sturdivant vs Hal Griggs | Fifth | 8 out |
| Tuesday, July 21 |
| » Lost to Tigers (44-50), 8-1 | Tiger Stadium (3-4) | 43-48 | Lost 2 |
| » Starters: Bill Fischer vs Paul Foytack | Fifth | 9 out |
| Wednesday, July 22 |
| » Lost to Tigers (45-50), 6-2 | Tiger Stadium (3-5) | 43-49 | Lost 3 |
| » Starters: Pedro Ramos vs Frank Lary | Sixth | 10 out |
| Thursday, July 23 |
| » Lost to Tigers (46-50), 11-2 | Tiger Stadium (3-6) | 43-50 | Lost 4 |
| » Starters: Hal Woodeshick vs Jim Bunning | Seventh | 10½ out |
| Friday, July 24 |
| » Lost to Indians (53-39), 5-2 | Cleveland Stadium (3-2) | 43-51 | Lost 5 |
| » Starters: Camilo Pascual vs Gary Bell | Seventh | 11½ out |
| Saturday, July 25 |
| » Lost to Indians (54-39), 8-1 | Cleveland Stadium (3-3) | 43-52 | Lost 6 |
| » Starters: Bill Fischer vs Cal McLish | Sixth | 12½ out |
| Sunday, July 26 |
| » Lost to Indians (55-39), 9-0 | Cleveland Stadium (3-4) | 43-53 | Lost 7 |
| » Starters: Hal Griggs vs Jim Perry | Seventh | 14 out |
| » Lost to Indians (56-39), 4-3 | Cleveland Stadium (3-5) | 43-54 | Lost 8 |
| » Starters: Pedro Ramos vs Bobby Locke | Seventh | 14 out |
| Monday, July 27 |
| » Lost to Athletics (47-49), 7-6 | Municipal Stadium (3-3) | 43-55 | Lost 9 |
| » Starters: John Romonosky vs Ned Garver | Sixth | 14 out |
| Tuesday, July 28 |
| » Lost to Athletics (48-49), 6-1 | Municipal Stadium (3-4) | 43-56 | Lost 10 |
| » Starters: Camilo Pascual vs Johnny Kucks | Seventh | 15 out |
| Wednesday, July 29 |
| » Lost to Athletics (49-49), 5-4 | Municipal Stadium (3-5) | 43-57 | Lost 11 |
| » Starters: Bill Fischer vs John Tsitouris | Eighth | 15½ out |
| Thursday, July 30 |
| » Lost to Athletics (50-49), 4-1 | Municipal Stadium (3-6) | 43-58 | Lost 12 |
| » Starters: Hal Griggs vs Bud Daley | Eighth | 16½ out |
| Friday, July 31 |
| » Lost to White Sox (59-40), 7-1 | Comiskey Park I (3-3) | 43-59 | Lost 13 |
| » Starters: Pedro Ramos vs Barry Latman | Eighth | 17½ out |
| Saturday, August 1 |
| » Lost to White Sox (60-40), 2-1 | Comiskey Park I (3-4) | 43-60 | Lost 14 |
| » Starters: Camilo Pascual vs Ray Moore | Eighth | 18½ out |
| » Major-league debuts: Zoilo Versalles (Senators) |
| Sunday, August 2 |
| » Lost to White Sox (61-40), 3-2 | Comiskey Park I (3-5) | 43-61 | Lost 15 |
| » Starters: Russ Kemmerer vs Billy Pierce | Eighth | 20½ out |
| » Lost to White Sox (62-40), 9-3 | Comiskey Park I (3-6) | 43-62 | Lost 16 |
| » Starters: Jim Kaat vs Bob Shaw | Eighth | 20½ out |
| » Major-league debuts: Jim Kaat (Senators) |
| Tuesday, August 4 |
| » Lost to Indians (61-44), 8-2 | Griffith Stadium (23-29) | 43-63 | Lost 17 |
| » Starters: Jim Perry vs Bill Fischer | Eighth | 20½ out |
| Wednesday, August 5 |
| » Lost to Indians (62-44), 7-3 | Griffith Stadium (23-30) | 43-64 | Lost 18 |
| » Starters: Mudcat Grant vs Pedro Ramos | Eighth | 20½ out |
| » Defeated Indians (62-45), 9-0 | Griffith Stadium (24-30) | 44-64 | |
| » Starters: Cal McLish vs Tex Clevenger | Eighth | 20½ out |
| Thursday, August 6 |
| » Lost to Indians (63-45), 5-2 | Griffith Stadium (24-31) | 44-65 | |
| » Starters: Gary Bell vs Russ Kemmerer | Eighth | 21 out |
| Friday, August 7 |
| » Lost to White Sox (64-42), 4-1 | Griffith Stadium (24-32) | 44-66 | Lost 2 |
| » Starters: Bob Shaw vs Bill Fischer | Eighth | 22 out |
| Sunday, August 9 |
| » Lost to White Sox (65-42), 4-3 | Griffith Stadium (24-33) | 44-67 | Lost 3 |
| » Starters: Ken McBride vs Chuck Stobbs | Eighth | 24 out |
| » Lost to White Sox (66-42), 9-0 | Griffith Stadium (24-34) | 44-68 | Lost 4 |
| » Starters: Early Wynn vs Tex Clevenger | Eighth | 24 out |
| Wednesday, August 12 |
| » Defeated Yankees (57-55), 3-2 | Yankee Stadium (4-4) | 45-68 | |
| » Starters: Pedro Ramos vs Art Ditmar | Eighth | 23½ out |
| Former Senator Ed Goebel dies in Brooklyn, NY at the age of 60. |
| Thursday, August 13 |
| » Defeated Yankees (57-56), 5-2 | Yankee Stadium (5-4) | 46-68 | Won 2 |
| » Starters: Russ Kemmerer vs Bob Turley | Eighth | 23½ out |
| Friday, August 14 |
| » Defeated Orioles (56-57), 7-3 | Memorial Stadium (3-4) | 47-68 | Won 3 |
| » Starters: Bill Fischer vs Hal Brown | Eighth | 23½ out |
| Saturday, August 15 |
| » Lost to Orioles (57-57), 4-2 | Memorial Stadium (3-5) | 47-69 | |
| » Starters: Chuck Stobbs vs Milt Pappas | Eighth | 23½ out |
| Sunday, August 16 |
| » Defeated Orioles (57-58), 6-1 | Memorial Stadium (4-5) | 48-69 | |
| » Starters: Pedro Ramos vs Jerry Walker | Eighth | 22½ out |
| Tuesday, August 18 |
| » Defeated Indians (67-51), 11-4 | Cleveland Stadium (4-5) | 49-69 | Won 2 |
| » Starters: Russ Kemmerer vs Jim Perry | Seventh | 22½ out |
| Wednesday, August 19 |
| » Lost to Indians (68-51), 5-4 | Cleveland Stadium (4-6) | 49-70 | |
| » Starters: Bill Fischer vs Cal McLish | Eighth | 22½ out |
| Thursday, August 20 |
| » Lost to Indians (69-51), 6-1 | Cleveland Stadium (4-7) | 49-71 | Lost 2 |
| » Starters: Pedro Ramos vs Mudcat Grant | Seventh | 22½ out |
| Friday, August 21 |
| » Lost to White Sox (71-47), 5-4 | Comiskey Park I (3-7) | 49-72 | Lost 3 |
| » Starters: Chuck Stobbs vs Dick Donovan | Seventh | 23½ out |
| Saturday, August 22 |
| » Lost to White Sox (72-47), 1-0 | Comiskey Park I (3-8) | 49-73 | Lost 4 |
| » Starters: Russ Kemmerer vs Barry Latman | Seventh | 24½ out |
| Sunday, August 23 |
| » Defeated Athletics (57-66), 7-3 | Municipal Stadium (4-6) | 50-73 | |
| » Starters: Camilo Pascual vs Bud Daley | Eighth | 24½ out |
| » Lost to Athletics (58-66), 5-2 | Municipal Stadium (4-7) | 50-74 | |
| » Starters: Hal Woodeshick vs Johnny Kucks | Eighth | 24½ out |
| Tuesday, August 25 |
| » Defeated Tigers (61-65), 3-1 | Tiger Stadium (4-6) | 51-74 | |
| » Starters: Pedro Ramos vs Paul Foytack | Eighth | 25 out |
| Wednesday, August 26 |
| » Lost to Tigers (62-65), 3-2 | Tiger Stadium (4-7) | 51-75 | |
| » Starters: Russ Kemmerer vs Jim Bunning | Seventh | 25 out |
| Friday, August 28 |
| » Lost to Yankees (63-65), 4-0 | Griffith Stadium (24-35) | 51-76 | Lost 2 |
| » Starters: Art Ditmar vs Camilo Pascual | Seventh | 26½ out |
| Saturday, August 29 |
| » Lost to Yankees (64-65), 9-5 | Griffith Stadium (24-36) | 51-77 | Lost 3 |
| » Starters: Bob Turley vs Pedro Ramos | Seventh | 27½ out |
| Sunday, August 30 |
| » Defeated Yankees (64-66), 3-1 | Griffith Stadium (25-36) | 52-77 | |
| » Starters: Ralph Terry vs Russ Kemmerer | Eighth | 28 out |
| Monday, August 31 |
| » Lost to Red Sox (62-69), 4-3 | Fenway Park (3-4) | 52-78 | |
| » Starters: Bill Fischer vs Bill Monbouquette | Eighth | 28½ out |
| Tuesday, September 1 |
| » Defeated Red Sox (62-70), 7-4 | Fenway Park (4-4) | 53-78 | |
| » Starters: Camilo Pascual vs Earl Wilson | Eighth | 27½ out |
| Wednesday, September 2 |
| » Lost to Yankees (66-66), 4-3 | Yankee Stadium (5-5) | 53-79 | |
| » Starters: Pedro Ramos vs Duke Maas | Eighth | 29 out |
| Thursday, September 3 |
| » Lost to Yankees (67-66), 9-2 | Yankee Stadium (5-6) | 53-80 | Lost 2 |
| » Starters: Russ Kemmerer vs Art Ditmar | Eighth | 29½ out |
| Friday, September 4 |
| » Defeated Red Sox (62-73), 4-3 | Griffith Stadium (26-36) | 54-80 | |
| » Starters: Frank Sullivan vs Tex Clevenger | Seventh | 29½ out |
| Saturday, September 5 |
| » Defeated Red Sox (62-74), 14-2 | Griffith Stadium (27-36) | 55-80 | Won 2 |
| » Starters: Bill Monbouquette vs Camilo Pascual | Seventh | 28½ out |
| Sunday, September 6 |
| » Lost to Red Sox (63-74), 2-1 | Griffith Stadium (27-37) | 55-81 | |
| » Starters: Tom Brewer vs Pedro Ramos | Eighth | 28½ out |
| Monday, September 7 |
| » Lost to Orioles (66-68), 7-0 | Memorial Stadium (4-6) | 55-82 | Lost 2 |
| » Starters: Russ Kemmerer vs Billy O'Dell | Eighth | 29½ out |
| » Defeated Orioles (66-69), 8-1 | Memorial Stadium (5-6) | 56-82 | |
| » Starters: Bill Fischer vs Jack Fisher | Eighth | 29½ out |
| » Major-league debuts: Fred Valentine (Orioles) |
| Wednesday, September 9 |
| » Lost to White Sox (87-52), 5-1 | Griffith Stadium (27-38) | 56-83 | |
| » Starters: Bob Shaw vs Tex Clevenger | Eighth | 31 out |
| » Major-league debuts: Dan Dobbek (Senators) |
| Thursday, September 10 |
| » Defeated White Sox (87-53), 8-2 | Griffith Stadium (28-38) | 57-83 | |
| » Starters: Dick Donovan vs Camilo Pascual | Eighth | 30 out |
| » Major-league debuts: J.C. Martin and Gary Peters (White Sox) |
| Friday, September 11 |
| » Defeated Indians (82-58), 5-4 | Griffith Stadium (29-38) | 58-83 | Won 2 |
| » Starters: Mudcat Grant vs Pedro Ramos | Eighth | 28½ out |
| Saturday, September 12 |
| » Lost to Indians (83-58), 7-2 | Griffith Stadium (29-39) | 58-84 | |
| » Starters: Gary Bell vs Russ Kemmerer | Eighth | 29½ out |
| Sunday, September 13 |
| » Defeated Tigers (71-72), 5-1 | Griffith Stadium (30-39) | 59-84 | |
| » Starters: Jim Bunning vs Bill Fischer | Eighth | 29½ out |
| Monday, September 14 |
| » Defeated Tigers (71-73), 5-0 | Griffith Stadium (31-39) | 60-84 | Won 2 |
| » Starters: Ray Narleski vs Tex Clevenger | Eighth | 28½ out |
| » Major-league debuts: Bob Bruce and Jim Proctor (Tigers) |
| Tuesday, September 15 |
| » Defeated Athletics (62-82), 1-0 | Griffith Stadium (32-39) | 61-84 | Won 3 |
| » Starters: John Tsitouris vs Camilo Pascual | Seventh | 29 out |
| » Lost to Athletics (63-82), 6-2 | Griffith Stadium (32-40) | 61-85 | |
| » Starters: Johnny Kucks vs Pedro Ramos | Seventh | 29 out |
| Friday, September 18 |
| » Defeated Orioles (71-76), 5-3 | Griffith Stadium (33-40) | 62-85 | |
| » Starters: Jerry Walker vs Bill Fischer | Eighth | 28½ out |
| Saturday, September 19 |
| » Lost to Orioles (72-76), 5-3 | Griffith Stadium (33-41) | 62-86 | |
| » Starters: Milt Pappas vs Tex Clevenger | Eighth | 28½ out |
| Sunday, September 20 |
| » Defeated Orioles (72-77), 5-0 | Griffith Stadium (34-41) | 63-86 | |
| » Starters: Billy O'Dell vs Camilo Pascual | Eighth | 27½ out |
| Former Senator Tilly Walker dies in Unicoi, TN at the age of 73. |
| Tuesday, September 22 |
| » Lost to Yankees (77-73), 8-4 | Griffith Stadium (34-42) | 63-87 | |
| » Starters: Art Ditmar vs Pedro Ramos | Eighth | 28½ out |
| Wednesday, September 23 |
| » Lost to Yankees (78-73), 5-4 | Griffith Stadium (34-43) | 63-88 | Lost 2 |
| » Starters: Ralph Terry vs Bill Fischer | Seventh | 29 out |
| Friday, September 25 |
| » Lost to Red Sox (73-79), 10-4 | Fenway Park (4-5) | 63-89 | Lost 3 |
| » Starters: Tex Clevenger vs Earl Wilson | Eighth | 29 out |
| » Major-league debuts: Don Gile (Red Sox) |
| Saturday, September 26 |
| » Lost to Red Sox (74-79), 5-4 | Fenway Park (4-6) | 63-90 | Lost 4 |
| » Starters: Camilo Pascual vs Bill Monbouquette | Eighth | 30 out |
| Sunday, September 27 |
| » Lost to Red Sox (75-79), 6-2 | Fenway Park (4-7) | 63-91 | Lost 5 |
| » Starters: Jim Kaat vs Jerry Casale | Eighth | 31 out |
| » Major-league debuts: Tom McAvoy (Senators) |
| Sunday, December 6 |
| Former Senator Wid Conroy dies in Mt.Holly, NJ at the age of 83. |
| Thursday, December 10 |
| Former Senator Joe Harris dies in Renton, PA at the age of 69. |
Game information provided by Retrosheet (www.retrosheet.org) |
