| Friday, January 9 |
| Future Red Sox Otis Nixon is born in Columbus County, NC. |
| Friday, January 30 |
| Future Red Sox La Schelle Tarver is born in Modesto, CA. |
| Sunday, February 15 |
| Future Red Sox Joe Hesketh is born in Lackawanna, NY. |
| Wednesday, March 4 |
| Future Red Sox Mike Brown is born in Camden County, NJ. |
| Tuesday, March 17 |
| Former Red Sox Howard Ehmke dies in Philadelphia, PA at the age of 65. |
| Thursday, April 2 |
| Future Red Sox Al Nipper is born in San Diego, CA. |
| Saturday, April 11 |
| » Major-league debuts: George Altman (Cubs) Jim Baxes (Dodgers) |
| Sunday, April 12 |
| » Lost to Yankees (1-0), 3-2 | Yankee Stadium (0-1) | 0-1 | |
| » Starters: Tom Brewer vs Bob Turley | Fourth | 2 out |
| Tuesday, April 14 |
| » Defeated Senators (1-1), 7-3 | Fenway Park (1-0) | 1-1 | |
| » Starters: Camilo Pascual vs Ike Delock | Fourth | 2 out |
| Wednesday, April 15 |
| » Defeated Senators (1-2), 7-3 | Fenway Park (2-0) | 2-1 | Won 2 |
| » Starters: Russ Kemmerer vs Jerry Casale | Fourth | 1½ out |
| » Major-league debuts: Jack Kralick (Senators) |
| Thursday, April 16 |
| » Lost to Senators (2-2), 7-5 | Fenway Park (2-1) | 2-2 | |
| » Starters: Pedro Ramos vs Herb Moford | Fourth | 2 out |
| Friday, April 17 |
| » Defeated Yankees (3-2), 4-0 | Fenway Park (3-1) | 3-2 | |
| » Starters: Bob Turley vs Tom Brewer | Third | 2 out |
| Saturday, April 18 |
| » Lost to Yankees (4-2), 16-7 | Fenway Park (3-2) | 3-3 | |
| » Starters: Duke Maas vs Ted Bowsfield | Fourth | 3 out |
| » Major-league debuts: Mark Freeman (Yankees) |
| Sunday, April 19 |
| » Defeated Yankees (4-3), 5-4 | Fenway Park (4-2) | 4-3 | |
| » Starters: Johnny Kucks vs Ike Delock | Third | 2 out |
| Tuesday, April 21 |
| » Lost to Orioles (5-4), 5-2 | Fenway Park (4-3) | 4-4 | |
| » Starters: Hoyt Wilhelm vs Jerry Casale | Fourth | 3 out |
| Wednesday, April 22 |
| » Defeated Orioles (5-5), 8-4 | Fenway Park (5-3) | 5-4 | |
| » Starters: Arnie Portocarrero vs Tom Brewer | Fourth | 3 out |
| Thursday, April 23 |
| » Lost to Orioles (6-5), 8-7 | Fenway Park (5-4) | 5-5 | |
| » Starters: Milt Pappas vs Ted Bowsfield | Fourth | 4 out |
| Friday, April 24 |
| » Defeated Senators (4-8), 7-2 | Griffith Stadium (1-0) | 6-5 | |
| » Starters: Ike Delock vs Vito Valentinetti | Third | 4 out |
| Saturday, April 25 |
| » Lost to Senators (5-8), 8-4 | Griffith Stadium (1-1) | 6-6 | |
| » Starters: Herb Moford vs Pedro Ramos | Fourth | 4 out |
| Sunday, April 26 |
| » Lost to Senators (6-8), 2-1 | Griffith Stadium (1-2) | 6-7 | Lost 2 |
| » Starters: Jerry Casale vs Bill Fischer | Fourth | 3½ out |
| Friday, May 1 |
| » Lost to White Sox (11-6), 1-0 | Comiskey Park I (0-1) | 6-8 | Lost 3 |
| » Starters: Tom Brewer vs Early Wynn | Seventh | 4½ out |
| Saturday, May 2 |
| » Defeated White Sox (11-7), 5-4 | Comiskey Park I (1-1) | 7-8 | |
| » Starters: Ike Delock vs Barry Latman | Fifth | 4½ out |
| Sunday, May 3 |
| » Lost to Athletics (11-8), 7-3 | Municipal Stadium (0-1) | 7-9 | |
| » Starters: Frank Sullivan vs Ralph Terry | Fourth | 5 out |
| Monday, May 4 |
| » Defeated Athletics (11-9), 8-4 | Municipal Stadium (1-1) | 8-9 | |
| » Starters: Frank Baumann vs John Tsitouris | Fifth | 4½ out |
| Tuesday, May 5 |
| » Lost to Tigers (5-15), 8-3 | Tiger Stadium (0-1) | 8-10 | |
| » Starters: Jerry Casale vs Jim Bunning | Fifth | 5½ out |
| Wednesday, May 6 |
| » Defeated Tigers (5-16), 17-6 | Tiger Stadium (1-1) | 9-10 | |
| » Starters: Tom Brewer vs Paul Foytack | Sixth | 4½ out |
| Thursday, May 7 |
| » Lost to Tigers (6-16), 3-1 | Tiger Stadium (1-2) | 9-11 | |
| » Starters: Ike Delock vs Frank Lary | Sixth | 5 out |
| Friday, May 8 |
| » Defeated Orioles (13-10), 5-0 | Memorial Stadium (1-0) | 10-11 | |
| » Starters: Frank Sullivan vs Billy O'Dell | Sixth | 5 out |
| Saturday, May 9 |
| » Lost to Orioles (14-10), 4-3 | Memorial Stadium (1-1) | 10-12 | |
| » Starters: Billy Hoeft vs Hoyt Wilhelm | Sixth | 5 out |
| Sunday, May 10 |
| » Defeated Orioles (14-11), 3-2 | Memorial Stadium (2-1) | 11-12 | |
| » Starters: Tom Brewer vs Arnie Portocarrero | Fifth | 3 out |
| » Defeated Orioles (14-12), 5-1 | Memorial Stadium (3-1) | 12-12 | Won 2 |
| » Starters: Frank Baumann vs Hal Brown | Fifth | 3 out |
| Tuesday, May 12 |
| » Lost to White Sox (15-11), 4-3 | Fenway Park (5-5) | 12-13 | |
| » Starters: Dick Donovan vs Ike Delock | Fifth | 4 out |
| Wednesday, May 13 |
| » Lost to White Sox (16-11), 4-0 | Fenway Park (5-6) | 12-14 | Lost 2 |
| » Starters: Bob Shaw vs Frank Sullivan | Fifth | 4½ out |
| Thursday, May 14 |
| » Lost to White Sox (17-11), 14-6 | Fenway Park (5-7) | 12-15 | Lost 3 |
| » Starters: Early Wynn vs Billy Hoeft | Sixth | 5 out |
| Friday, May 15 |
| » Lost to Indians (17-9), 4-3 | Fenway Park (5-8) | 12-16 | Lost 4 |
| » Starters: Mudcat Grant vs Tom Brewer | Sixth | 6 out |
| Saturday, May 16 |
| » Lost to Indians (18-9), 12-6 | Fenway Park (5-9) | 12-17 | Lost 5 |
| » Starters: Herb Score vs Frank Baumann | Sixth | 7 out |
| Sunday, May 17 |
| » Defeated Tigers (10-20), 10-1 | Fenway Park (6-9) | 13-17 | |
| » Starters: Paul Foytack vs Ike Delock | Sixth | 6½ out |
| Monday, May 18 |
| » Lost to Tigers (11-20), 14-2 | Fenway Park (6-10) | 13-18 | |
| » Starters: Jim Bunning vs Frank Sullivan | Sixth | 7 out |
| Wednesday, May 20 |
| » Lost to Athletics (15-16), 8-2 | Fenway Park (6-11) | 13-19 | Lost 2 |
| » Starters: Ray Herbert vs Billy Hoeft | Sixth | 8 out |
| Thursday, May 21 |
| » Defeated Athletics (15-17), 5-0 | Fenway Park (7-11) | 14-19 | |
| » Starters: Ned Garver vs Tom Brewer | Sixth | 7½ out |
| Friday, May 22 |
| » Defeated Senators (17-21), 4-3 | Fenway Park (8-11) | 15-19 | Won 2 |
| » Starters: Camilo Pascual vs Ike Delock | Sixth | 7½ out |
| Saturday, May 23 |
| » Lost to Senators (18-21), 10-4 | Fenway Park (8-12) | 15-20 | |
| » Starters: Pedro Ramos vs Frank Sullivan | Sixth | 7½ out |
| Sunday, May 24 |
| » Lost to Senators (19-21), 8-3 | Fenway Park (8-13) | 15-21 | Lost 2 |
| » Starters: Bill Fischer vs Jerry Casale | Sixth | 8 out |
| » Major-league debuts: Ted Wills (Red Sox) |
| Tuesday, May 26 |
| » Defeated Yankees (14-22), 12-2 | Yankee Stadium (1-1) | 16-21 | |
| » Starters: Tom Brewer vs Bob Turley | Seventh | 8 out |
| Wednesday, May 27 |
| » Lost to Yankees (15-22), 3-2 | Yankee Stadium (1-2) | 16-22 | |
| » Starters: Ike Delock vs Duke Maas | Seventh | 8 out |
| Thursday, May 28 |
| » Defeated Senators (20-23), 3-1 | Griffith Stadium (2-2) | 17-22 | |
| » Starters: Frank Sullivan vs Pedro Ramos | Sixth | 7 out |
| Friday, May 29 |
| » Lost to Senators (21-23), 7-6 | Griffith Stadium (2-3) | 17-23 | |
| » Starters: Bill Monbouquette vs Bill Fischer | Seventh | 7½ out |
| Saturday, May 30 |
| » Defeated Orioles (24-20), 5-4 | Fenway Park (9-13) | 18-23 | |
| » Starters: Milt Pappas vs Tom Brewer | Sixth | 6½ out |
| » Defeated Orioles (24-21), 8-3 | Fenway Park (10-13) | 19-23 | Won 2 |
| » Starters: Jerry Walker vs Ted Wills | Sixth | 6½ out |
| Sunday, May 31 |
| » Lost to Orioles (25-21), 2-1 | Fenway Park (10-14) | 19-24 | |
| » Starters: Hal Brown vs Ike Delock | Eighth | 6½ out |
| Tuesday, June 2 |
| » Lost to Athletics (22-21), 5-3 | Municipal Stadium (1-2) | 19-25 | Lost 2 |
| » Starters: Frank Sullivan vs Ray Herbert | Eighth | 6 out |
| Wednesday, June 3 |
| » Lost to Athletics (23-21), 5-3 | Municipal Stadium (1-3) | 19-26 | Lost 3 |
| » Starters: Bill Monbouquette vs Johnny Kucks | Eighth | 6 out |
| Thursday, June 4 |
| » Defeated Athletics (23-22), 5-2 | Municipal Stadium (2-3) | 20-26 | |
| » Starters: Jerry Casale vs Rip Coleman | Eighth | 6 out |
| Friday, June 5 |
| » Lost to White Sox (28-21), 5-2 | Comiskey Park I (1-2) | 20-27 | |
| » Starters: Frank Baumann vs Early Wynn | Eighth | 7 out |
| Saturday, June 6 |
| » Defeated White Sox (28-22), 4-2 | Comiskey Park I (2-2) | 21-27 | |
| » Starters: Ted Wills vs Ray Moore | Eighth | 6 out |
| Sunday, June 7 |
| » Lost to White Sox (29-22), 9-4 | Comiskey Park I (2-3) | 21-28 | |
| » Starters: Ike Delock vs Dick Donovan | Eighth | 6 out |
| » Defeated White Sox (29-23), 4-2 | Comiskey Park I (3-3) | 22-28 | |
| » Starters: Frank Sullivan vs Billy Pierce | Eighth | 6 out |
| Monday, June 8 |
| » Lost to Tigers (26-25), 6-3 | Fenway Park (10-15) | 22-29 | |
| » Starters: Jim Bunning vs Tom Brewer | Eighth | 6½ out |
| Tuesday, June 9 |
| » Defeated Tigers (26-26), 5-2 | Fenway Park (11-15) | 23-29 | |
| » Starters: Jerry Davie vs Jerry Casale | Seventh | 5½ out |
| Wednesday, June 10 |
| » Lost to Tigers (27-26), 10-9 | Fenway Park (11-16) | 23-30 | |
| » Starters: Paul Foytack vs Ike Delock | Eighth | 6½ out |
| Thursday, June 11 |
| » Lost to Tigers (28-26), 8-1 | Fenway Park (11-17) | 23-31 | Lost 2 |
| » Starters: Ray Narleski vs Ted Wills | Eighth | 7½ out |
| Friday, June 12 |
| » Lost to Athletics (26-26), 3-2 | Fenway Park (11-18) | 23-32 | Lost 3 |
| » Starters: Rip Coleman vs Frank Sullivan | Seventh | 8 out |
| Saturday, June 13 |
| » Defeated Athletics (26-27), 6-1 | Fenway Park (12-18) | 24-32 | |
| » Starters: Ray Herbert vs Tom Brewer | Seventh | 7 out |
| Sunday, June 14 |
| » Defeated Athletics (26-28), 6-1 | Fenway Park (13-18) | 25-32 | Won 2 |
| » Starters: Johnny Kucks vs Jerry Casale | Seventh | 7½ out |
| Monday, June 15 |
| » Lost to Indians (32-24), 5-1 | Fenway Park (13-19) | 25-33 | |
| » Starters: Gary Bell vs Bill Monbouquette | Seventh | 8 out |
| Tuesday, June 16 |
| » Lost to Indians (33-24), 4-1 | Fenway Park (13-20) | 25-34 | Lost 2 |
| » Starters: Cal McLish vs Ted Wills | Seventh | 9 out |
| Thursday, June 18 |
| » Defeated Indians (33-25), 7-6 | Fenway Park (14-20) | 26-34 | |
| » Starters: Bobby Locke vs Frank Sullivan | Seventh | 8 out |
| » Major-league debuts: Larry Locke (Indians) |
| Saturday, June 20 |
| » Defeated White Sox (33-29), 8-2 | Fenway Park (15-20) | 27-34 | Won 2 |
| » Starters: Early Wynn vs Tom Brewer | Sixth | 6 out |
| » Defeated White Sox (33-30), 9-0 | Fenway Park (16-20) | 28-34 | Won 3 |
| » Starters: Dick Donovan vs Jerry Casale | Sixth | 6 out |
| Sunday, June 21 |
| » Lost to White Sox (34-30), 3-2 | Fenway Park (16-21) | 28-35 | |
| » Starters: Billy Pierce vs Ted Wills | Seventh | 7½ out |
| Tuesday, June 23 |
| » Defeated Tigers (34-32), 10-4 | Tiger Stadium (2-2) | 29-35 | |
| » Starters: Ike Delock vs Paul Foytack | Sixth | 6½ out |
| Wednesday, June 24 |
| » Defeated Tigers (34-33), 4-2 | Tiger Stadium (3-2) | 30-35 | Won 2 |
| » Starters: Jack Harshman vs Don Mossi | Sixth | 5½ out |
| Thursday, June 25 |
| » Lost to Tigers (35-33), 10-5 | Tiger Stadium (3-3) | 30-36 | |
| » Starters: Tom Brewer vs Jim Bunning | Sixth | 6½ out |
| Future Red Sox Alejandro Pena is born in Cambiaso, D.R. |
| Friday, June 26 |
| » Lost to Indians (37-29), 11-5 | Cleveland Stadium (0-1) | 30-37 | Lost 2 |
| » Starters: Jerry Casale vs Cal McLish | Sixth | 7½ out |
| Saturday, June 27 |
| » Defeated Indians (37-30), 6-4 | Cleveland Stadium (1-1) | 31-37 | |
| » Starters: Frank Sullivan vs Mudcat Grant | Sixth | 6½ out |
| Sunday, June 28 |
| » Lost to Indians (38-30), 5-4 | Cleveland Stadium (1-2) | 31-38 | |
| » Starters: Ike Delock vs Gary Bell | Seventh | 8½ out |
| » Lost to Indians (39-30), 1-0 | Cleveland Stadium (1-3) | 31-39 | Lost 2 |
| » Starters: Ted Wills vs Herb Score | Seventh | 8½ out |
| Tuesday, June 30 |
| » Lost to Senators (33-39), 6-1 | Griffith Stadium (2-4) | 31-40 | Lost 3 |
| » Starters: Tom Brewer vs Pedro Ramos | Eighth | 9½ out |
| Wednesday, July 1 |
| » Lost to Senators (34-39), 4-1 | Griffith Stadium (2-5) | 31-41 | Lost 4 |
| » Starters: Jerry Casale vs Camilo Pascual | Eighth | 9½ out |
| Thursday, July 2 |
| » Lost to Senators (35-39), 6-3 | Griffith Stadium (2-6) | 31-42 | Lost 5 |
| » Starters: Frank Sullivan vs Bill Fischer | Eighth | 9½ out |
| Friday, July 3 |
| » Lost to Orioles (40-36), 6-1 | Memorial Stadium (3-2) | 31-43 | Lost 6 |
| » Manager: Rudy York |
| » Starters: Jack Harshman vs Jack Fisher | Eighth | 10½ out |
| Saturday, July 4 |
| » Lost to Orioles (41-36), 11-5 | Memorial Stadium (3-3) | 31-44 | Lost 7 |
| » Manager: Billy Jurges |
| » Starters: Ted Wills vs Milt Pappas | Eighth | 12 out |
| Sunday, July 5 |
| » Defeated Orioles (41-37), 9-0 | Memorial Stadium (4-3) | 32-44 | |
| » Starters: Tom Brewer vs Hal Brown | Eighth | 11½ out |
| » Defeated Orioles (41-38), 6-3 | Memorial Stadium (5-3) | 33-44 | Won 2 |
| » Starters: Frank Baumann vs Hoyt Wilhelm | Eighth | 11½ out |
| Tuesday, July 7 |
| Former Red Sox Norwood Gibson dies in Peoria, IL at the age of 83. |
| Wednesday, July 8 |
| » Lost to Yankees (41-38), 11-5 | Yankee Stadium (1-3) | 33-45 | |
| » Starters: Ike Delock vs Don Larsen | Seventh | 12 out |
| Thursday, July 9 |
| » Defeated Yankees (41-39), 14-3 | Fenway Park (17-21) | 34-45 | |
| » Starters: Bob Turley vs Frank Sullivan | Eighth | 11 out |
| Friday, July 10 |
| » Defeated Yankees (41-40), 8-5 | Fenway Park (18-21) | 35-45 | Won 2 |
| » Starters: Whitey Ford vs Tom Brewer | Eighth | 11 out |
| » Major-league debuts: Eli Grba (Yankees) |
| Saturday, July 11 |
| » Defeated Yankees (41-41), 8-4 | Fenway Park (19-21) | 36-45 | Won 3 |
| » Starters: Duke Maas vs Jerry Casale | Seventh | 11 out |
| Former Red Sox Frank Gilhooley dies in Toledo, OH at the age of 68. |
| Sunday, July 12 |
| » Defeated Yankees (41-42), 7-3 | Fenway Park (20-21) | 37-45 | Won 4 |
| » Starters: Ralph Terry vs Ike Delock | Seventh | 10½ out |
| Monday, July 13 |
| » Defeated Yankees (41-43), 13-3 | Fenway Park (21-21) | 38-45 | Won 5 |
| » Starters: Don Larsen vs Frank Sullivan | Seventh | 10 out |
| Tuesday, July 14 |
| » Lost to White Sox (48-36), 7-3 | Fenway Park (21-22) | 38-46 | |
| » Starters: Billy Pierce vs Ted Wills | Seventh | 10 out |
| Thursday, July 16 |
| » Lost to White Sox (49-36), 4-3 | Fenway Park (21-23) | 38-47 | Lost 2 |
| » Starters: Dick Donovan vs Tom Brewer | Seventh | 10 out |
| » Defeated White Sox (49-37), 5-4 | Fenway Park (22-23) | 39-47 | |
| » Starters: Barry Latman vs Jerry Casale | Seventh | 10 out |
| Friday, July 17 |
| » Lost to Indians (48-37), 8-7 | Fenway Park (22-24) | 39-48 | |
| » Starters: Bobby Locke vs Ike Delock | Seventh | 11 out |
| Saturday, July 18 |
| » Lost to Indians (49-37), 7-5 | Fenway Park (22-25) | 39-49 | Lost 2 |
| » Starters: Herb Score vs Frank Sullivan | Eighth | 12 out |
| Sunday, July 19 |
| » Defeated Indians (49-38), 6-5 | Fenway Park (23-25) | 40-49 | |
| » Starters: Gary Bell vs Bill Monbouquette | Eighth | 11 out |
| » Lost to Indians (50-38), 5-3 | Fenway Park (23-26) | 40-50 | |
| » Starters: Mudcat Grant vs Frank Baumann | Eighth | 11 out |
| Tuesday, July 21 |
| » Lost to White Sox (52-39), 2-1 | Comiskey Park I (3-4) | 40-51 | Lost 2 |
| » Starters: Tom Brewer vs Dick Donovan | Eighth | 12 out |
| » Major-league debuts: Pumpsie Green (Red Sox) |
| Wednesday, July 22 |
| » Lost to White Sox (53-39), 5-4 | Comiskey Park I (3-5) | 40-52 | Lost 3 |
| » Starters: Jerry Casale vs Early Wynn | Eighth | 13 out |
| Friday, July 24 |
| » Lost to Athletics (44-49), 3-1 | Municipal Stadium (2-4) | 40-53 | Lost 4 |
| » Starters: Frank Sullivan vs Johnny Kucks | Eighth | 14 out |
| Saturday, July 25 |
| » Lost to Athletics (45-49), 3-0 | Municipal Stadium (2-5) | 40-54 | Lost 5 |
| » Starters: Al Schroll vs Bud Daley | Seventh | 15 out |
| Former Red Sox Buck O'Brien dies in Boston, MA at the age of 78. |
| Sunday, July 26 |
| » Lost to Athletics (46-49), 5-4 | Municipal Stadium (2-6) | 40-55 | Lost 6 |
| » Starters: Tom Brewer vs Ray Herbert | Eighth | 16 out |
| Former Red Sox Otto Miller dies in Belleville, IL at the age of 59. |
| Monday, July 27 |
| » Defeated Indians (56-40), 4-0 | Cleveland Stadium (2-3) | 41-55 | |
| » Starters: Jerry Casale vs Herb Score | Seventh | 15 out |
| Tuesday, July 28 |
| » Lost to Indians (57-40), 5-2 | Cleveland Stadium (2-4) | 41-56 | |
| » Starters: Frank Sullivan vs Gary Bell | Eighth | 15½ out |
| » Defeated Indians (57-41), 8-4 | Cleveland Stadium (3-4) | 42-56 | |
| » Starters: Bill Monbouquette vs Don Ferrarese | Eighth | 15½ out |
| » Major-league debuts: Jim Mahoney and Earl Wilson (Red Sox) |
| Wednesday, July 29 |
| » Defeated Indians (57-42), 4-1 | Cleveland Stadium (4-4) | 43-56 | Won 2 |
| » Starters: Al Schroll vs Cal McLish | Seventh | 15 out |
| Thursday, July 30 |
| » Lost to Indians (58-42), 4-3 | Cleveland Stadium (4-5) | 43-57 | |
| » Starters: Tom Brewer vs Mudcat Grant | Seventh | 16 out |
| Friday, July 31 |
| » Defeated Tigers (50-54), 6-5 | Tiger Stadium (4-3) | 44-57 | |
| » Starters: Earl Wilson vs Jim Bunning | Seventh | 16 out |
| Saturday, August 1 |
| » Lost to Tigers (51-54), 6-2 | Tiger Stadium (4-4) | 44-58 | |
| » Starters: Jerry Casale vs Don Mossi | Seventh | 17 out |
| Sunday, August 2 |
| » Defeated Tigers (51-55), 5-4 | Tiger Stadium (5-4) | 45-58 | |
| » Starters: Bill Monbouquette vs Paul Foytack | Seventh | 17½ out |
| Tuesday, August 4 |
| » Defeated Athletics (51-52), 4-1 | Fenway Park (24-26) | 46-58 | Won 2 |
| » Starters: John Tsitouris vs Tom Brewer | Seventh | 17 out |
| » Lost to Athletics (52-52), 8-6 | Fenway Park (24-27) | 46-59 | |
| » Starters: Rip Coleman vs Al Schroll | Seventh | 17 out |
| Wednesday, August 5 |
| » Defeated Athletics (52-53), 17-6 | Fenway Park (25-27) | 47-59 | |
| » Starters: Johnny Kucks vs Earl Wilson | Seventh | 16½ out |
| Thursday, August 6 |
| » Defeated Athletics (52-54), 4-3 | Fenway Park (26-27) | 48-59 | Won 2 |
| » Starters: Ray Herbert vs Jerry Casale | Seventh | 16 out |
| Friday, August 7 |
| » Defeated Tigers (53-57), 4-3 | Fenway Park (27-27) | 49-59 | Won 3 |
| » Starters: Jim Bunning vs Bill Monbouquette | Seventh | 16 out |
| Saturday, August 8 |
| » Defeated Tigers (53-58), 4-3 | Fenway Park (28-27) | 50-59 | Won 4 |
| » Starters: Frank Lary vs Al Schroll | Seventh | 15½ out |
| Sunday, August 9 |
| » Lost to Tigers (54-58), 7-3 | Fenway Park (28-28) | 50-60 | |
| » Starters: Don Mossi vs Tom Brewer | Seventh | 17 out |
| Monday, August 10 |
| » Lost to Yankees (56-54), 7-4 | Fenway Park (28-29) | 50-61 | Lost 2 |
| » Starters: Don Larsen vs Frank Sullivan | Seventh | 17½ out |
| Tuesday, August 11 |
| » Lost to Yankees (57-54), 8-5 | Fenway Park (28-30) | 50-62 | Lost 3 |
| » Starters: Duke Maas vs Jerry Casale | Seventh | 17½ out |
| Wednesday, August 12 |
| » Defeated Orioles (56-56), 5-4 | Memorial Stadium (6-3) | 51-62 | |
| » Starters: Bill Monbouquette vs Billy Hoeft | Seventh | 17½ out |
| Friday, August 14 |
| » Defeated Yankees (57-57), 11-6 | Yankee Stadium (2-3) | 52-62 | Won 2 |
| » Starters: Tom Brewer vs Whitey Ford | Seventh | 18 out |
| Saturday, August 15 |
| » Defeated Yankees (57-58), 12-4 | Yankee Stadium (3-3) | 53-62 | Won 3 |
| » Starters: Frank Sullivan vs Eli Grba | Seventh | 17 out |
| Sunday, August 16 |
| » Defeated Yankees (57-59), 6-5 | Yankee Stadium (4-3) | 54-62 | Won 4 |
| » Starters: Jerry Casale vs Duke Maas | Seventh | 16½ out |
| » Lost to Yankees (58-59), 4-2 | Yankee Stadium (4-4) | 54-63 | |
| » Starters: Bill Monbouquette vs Ralph Terry | Seventh | 16½ out |
| Tuesday, August 18 |
| » Defeated Athletics (55-63), 5-4 | Municipal Stadium (3-6) | 55-63 | |
| » Starters: Tom Brewer vs Johnny Kucks | Sixth | 16½ out |
| Wednesday, August 19 |
| » Lost to Athletics (56-63), 6-3 | Municipal Stadium (3-7) | 55-64 | |
| » Starters: Frank Sullivan vs Bud Daley | Seventh | 16½ out |
| Thursday, August 20 |
| » Defeated Athletics (56-64), 11-10 | Municipal Stadium (4-7) | 56-64 | |
| » Starters: Jerry Casale vs John Tsitouris | Sixth | 15½ out |
| Friday, August 21 |
| » Lost to Tigers (60-62), 2-0 | Tiger Stadium (5-5) | 56-65 | |
| » Starters: Bill Monbouquette vs Paul Foytack | Sixth | 16½ out |
| Saturday, August 22 |
| » Defeated Tigers (60-63), 7-1 | Tiger Stadium (6-5) | 57-65 | |
| » Starters: Frank Baumann vs Don Mossi | Sixth | 16½ out |
| » Major-league debuts: Ron Shoop (Tigers) |
| Sunday, August 23 |
| » Lost to Indians (72-51), 1-0 | Cleveland Stadium (4-6) | 57-66 | |
| » Starters: Tom Brewer vs Jim Perry | Seventh | 17½ out |
| » Lost to Indians (73-51), 6-2 | Cleveland Stadium (4-7) | 57-67 | Lost 2 |
| » Starters: Al Schroll vs Mike Garcia | Seventh | 17½ out |
| Tuesday, August 25 |
| » Lost to White Sox (75-48), 5-4 | Comiskey Park I (3-6) | 57-68 | Lost 3 |
| » Starters: Frank Sullivan vs Dick Donovan | Seventh | 19 out |
| Wednesday, August 26 |
| » Defeated White Sox (75-49), 7-6 | Comiskey Park I (4-6) | 58-68 | |
| » Starters: Bill Monbouquette vs Early Wynn | Sixth | 18 out |
| Thursday, August 27 |
| » Lost to White Sox (76-49), 5-1 | Comiskey Park I (4-7) | 58-69 | |
| » Starters: Frank Baumann vs Barry Latman | Sixth | 19 out |
| Friday, August 28 |
| » Defeated Orioles (61-64), 6-4 | Fenway Park (29-30) | 59-69 | |
| » Starters: Hal Brown vs Tom Brewer | Sixth | 19 out |
| Saturday, August 29 |
| » Defeated Orioles (61-65), 4-1 | Fenway Park (30-30) | 60-69 | Won 2 |
| » Starters: Milt Pappas vs Jerry Casale | Fifth | 19 out |
| Sunday, August 30 |
| » Defeated Orioles (61-66), 3-0 | Fenway Park (31-30) | 61-69 | Won 3 |
| » Starters: Hoyt Wilhelm vs Frank Sullivan | Sixth | 19½ out |
| Monday, August 31 |
| » Defeated Senators (52-78), 4-3 | Fenway Park (32-30) | 62-69 | Won 4 |
| » Starters: Bill Fischer vs Bill Monbouquette | Sixth | 19 out |
| Tuesday, September 1 |
| » Lost to Senators (53-78), 7-4 | Fenway Park (32-31) | 62-70 | |
| » Starters: Camilo Pascual vs Earl Wilson | Sixth | 19 out |
| Wednesday, September 2 |
| » Lost to Orioles (62-67), 4-0 | Memorial Stadium (6-4) | 62-71 | Lost 2 |
| » Starters: Tom Brewer vs Billy O'Dell | Sixth | 20½ out |
| Thursday, September 3 |
| » Lost to Orioles (63-67), 5-4 | Memorial Stadium (6-5) | 62-72 | Lost 3 |
| » Starters: Frank Baumann vs Hal Brown | Sixth | 21 out |
| Friday, September 4 |
| » Lost to Senators (54-80), 4-3 | Griffith Stadium (2-7) | 62-73 | Lost 4 |
| » Starters: Frank Sullivan vs Tex Clevenger | Fifth | 22 out |
| Saturday, September 5 |
| » Lost to Senators (55-80), 14-2 | Griffith Stadium (2-8) | 62-74 | Lost 5 |
| » Starters: Bill Monbouquette vs Camilo Pascual | Fifth | 22 out |
| Sunday, September 6 |
| » Defeated Senators (55-81), 2-1 | Griffith Stadium (3-8) | 63-74 | |
| » Starters: Tom Brewer vs Pedro Ramos | Sixth | 21 out |
| Monday, September 7 |
| » Defeated Yankees (68-69), 12-4 | Fenway Park (33-31) | 64-74 | Won 2 |
| » Starters: Duke Maas vs Jerry Casale | Sixth | 21½ out |
| Wednesday, September 9 |
| » Lost to Tigers (70-69), 3-1 | Fenway Park (33-32) | 64-75 | |
| » Starters: Jim Bunning vs Frank Sullivan | Sixth | 23 out |
| Thursday, September 10 |
| » Defeated Tigers (70-70), 7-3 | Fenway Park (34-32) | 65-75 | |
| » Starters: Frank Lary vs Bill Monbouquette | Sixth | 22 out |
| Friday, September 11 |
| » Lost to Athletics (60-79), 8-6 | Fenway Park (34-33) | 65-76 | |
| » Starters: John Tsitouris vs Tom Brewer | Sixth | 21½ out |
| Saturday, September 12 |
| » Defeated Athletics (60-80), 4-3 | Fenway Park (35-33) | 66-76 | |
| » Starters: Tom Sturdivant vs Jerry Casale | Sixth | 21½ out |
| Sunday, September 13 |
| » Lost to White Sox (89-55), 3-1 | Fenway Park (35-34) | 66-77 | |
| » Starters: Bob Shaw vs Frank Sullivan | Sixth | 22½ out |
| Monday, September 14 |
| » Defeated White Sox (89-56), 9-3 | Fenway Park (36-34) | 67-77 | |
| » Starters: Dick Donovan vs Bill Monbouquette | Sixth | 21½ out |
| Tuesday, September 15 |
| » Defeated Indians (84-61), 1-0 | Fenway Park (37-34) | 68-77 | Won 2 |
| » Starters: Mudcat Grant vs Tom Brewer | Fifth | 21½ out |
| Wednesday, September 16 |
| » Defeated Indians (84-62), 6-5 | Fenway Park (38-34) | 69-77 | Won 3 |
| » Starters: Gary Bell vs Jerry Casale | Sixth | 20½ out |
| Friday, September 18 |
| » Defeated Yankees (74-73), 6-4 | Yankee Stadium (5-4) | 70-77 | Won 4 |
| » Starters: Frank Baumann vs Duke Maas | Sixth | 20½ out |
| » Major-league debuts: John Gabler (Yankees) |
| Saturday, September 19 |
| » Lost to Yankees (75-73), 3-1 | Yankee Stadium (5-5) | 70-78 | |
| » Starters: Bill Monbouquette vs Whitey Ford | Sixth | 20½ out |
| » Major-league debuts: Jerry Mallett (Red Sox) |
| Sunday, September 20 |
| » Lost to Yankees (76-73), 7-4 | Yankee Stadium (5-6) | 70-79 | Lost 2 |
| » Starters: Tom Brewer vs Bob Turley | Sixth | 20½ out |
| Former Red Sox Tilly Walker dies in Unicoi, TN at the age of 73. |
| Tuesday, September 22 |
| » Defeated Orioles (72-78), 4-3 | Fenway Park (39-34) | 71-79 | |
| » Starters: Hoyt Wilhelm vs Frank Sullivan | Sixth | 20½ out |
| Future Red Sox Lee Graham is born in Summerfield, FL. |
| Wednesday, September 23 |
| » Defeated Orioles (72-79), 4-0 | Fenway Park (40-34) | 72-79 | Won 2 |
| » Starters: Jack Fisher vs Jerry Casale | Fifth | 20 out |
| Friday, September 25 |
| » Defeated Senators (63-89), 10-4 | Fenway Park (41-34) | 73-79 | Won 3 |
| » Starters: Tex Clevenger vs Earl Wilson | Fifth | 19 out |
| » Major-league debuts: Don Gile (Red Sox) |
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