| Thursday, January 8 |
| Future Indian Ramon Romero is born in San Pedro de Macoris, D.R. |
| Friday, January 9 |
| Future Indian Otis Nixon is born in Columbus County, NC. |
| Wednesday, February 4 |
| Future Indian Keith Creel is born in Dallas, TX. |
| Saturday, February 7 |
| Former Indian Nap Lajoie dies in Daytona Beach, FL at the age of 85. |
| Friday, March 13 |
| Future Indian Luis Aguayo is born in Vega Baja, P.R. |
| Sunday, March 15 |
| Future Indian Harold Baines is born in Easton, MD. |
| Sunday, March 29 |
| Former Indian Johnny Allen dies in St.Petersburg, FL at the age of 54. |
| Friday, April 10 |
| » Defeated Athletics (0-1), 6-4 | Municipal Stadium (1-0) | 1-0 | |
| » Starters: Gary Bell vs Bob Grim | First | -- |
| Saturday, April 11 |
| » Defeated Athletics (0-2), 3-2 | Municipal Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Don Ferrarese vs Ned Garver | First | -- |
| Tuesday, April 14 |
| » Defeated Tigers (0-4), 8-1 | Cleveland Stadium (1-0) | 3-0 | Won 3 |
| » Starters: Jim Bunning vs Herb Score | Second | ½ out |
| » Major-league debuts: Jerry Davie (Tigers) |
| Wednesday, April 15 |
| » Defeated Tigers (0-5), 2-1 | Cleveland Stadium (2-0) | 4-0 | Won 4 |
| » Starters: Paul Foytack vs Cal McLish | First | -- |
| Friday, April 17 |
| » Defeated Athletics (2-4), 4-3 | Cleveland Stadium (3-0) | 5-0 | Won 5 |
| » Starters: Rip Coleman vs Gary Bell | First | -- |
| » Major-league debuts: Ray Webster (Indians) |
| Saturday, April 18 |
| » Defeated Athletics (2-5), 13-4 | Cleveland Stadium (4-0) | 6-0 | Won 6 |
| » Starters: Ralph Terry vs Don Ferrarese | First | -- |
| Sunday, April 19 |
| » Lost to Athletics (3-5), 4-3 | Cleveland Stadium (4-1) | 6-1 | |
| » Starters: Ray Herbert vs Herb Score | First | -- |
| Tuesday, April 21 |
| » Defeated Tigers (1-7), 14-1 | Tiger Stadium (1-0) | 7-1 | |
| » Starters: Cal McLish vs Paul Foytack | First | -- |
| Former Indian Don Black dies in Cuyahoga Falls, OH at the age of 43. |
| Wednesday, April 22 |
| » Defeated Tigers (1-8), 10-1 | Tiger Stadium (2-0) | 8-1 | Won 2 |
| » Starters: Gary Bell vs Frank Lary | First | -- |
| » Major-league debuts: Gene Leek (Indians) |
| Future Indian Terry Francona is born in Aberdeen, SD. |
| Thursday, April 23 |
| » Defeated Tigers (1-9), 10-4 | Tiger Stadium (3-0) | 9-1 | Won 3 |
| » Starters: Jim Perry vs Ray Narleski | First | -- |
| » Major-league debuts: Jim Perry (Indians) |
| Friday, April 24 |
| » Defeated White Sox (6-5), 6-4 | Cleveland Stadium (5-1) | 10-1 | Won 4 |
| » Starters: Dick Donovan vs Herb Score | First | -- |
| » Major-league debuts: Don Dillard (Indians) |
| Saturday, April 25 |
| » Lost to White Sox (7-5), 8-6 | Cleveland Stadium (5-2) | 10-2 | |
| » Starters: Barry Latman vs Cal McLish | First | -- |
| Sunday, April 26 |
| » Lost to White Sox (8-5), 6-5 | Cleveland Stadium (5-3) | 10-3 | Lost 2 |
| » Starters: Early Wynn vs Don Ferrarese | First | -- |
| » Lost to White Sox (9-5), 5-2 | Cleveland Stadium (5-4) | 10-4 | Lost 3 |
| » Starters: Billy Pierce vs Gary Bell | First | -- |
| Friday, May 1 |
| » Defeated Yankees (7-9), 4-2 | Cleveland Stadium (6-4) | 11-4 | |
| » Starters: Art Ditmar vs Cal McLish | First | -- |
| Saturday, May 2 |
| » Defeated Yankees (7-10), 5-2 | Cleveland Stadium (7-4) | 12-4 | Won 2 |
| » Starters: Tom Sturdivant vs Herb Score | First | -- |
| Sunday, May 3 |
| » Defeated Senators (10-10), 5-0 | Cleveland Stadium (8-4) | 13-4 | Won 3 |
| » Starters: Pedro Ramos vs Mudcat Grant | First | -- |
| » Lost to Senators (11-10), 3-1 | Cleveland Stadium (8-5) | 13-5 | |
| » Starters: Hal Griggs vs Mike Garcia | First | -- |
| Tuesday, May 5 |
| » Defeated Orioles (11-9), 9-1 | Cleveland Stadium (9-5) | 14-5 | |
| » Starters: Jack Harshman vs Don Ferrarese | First | -- |
| Wednesday, May 6 |
| » Lost to Orioles (12-9), 6-5 | Cleveland Stadium (9-6) | 14-6 | |
| » Starters: Milt Pappas vs Gary Bell | First | -- |
| Friday, May 8 |
| » Defeated White Sox (11-11), 3-1 | Comiskey Park I (1-0) | 15-6 | |
| » Starters: Cal McLish vs Dick Donovan | First | -- |
| Saturday, May 9 |
| » Lost to White Sox (12-11), 9-5 | Comiskey Park I (1-1) | 15-7 | |
| » Starters: Herb Score vs Barry Latman | First | -- |
| Sunday, May 10 |
| » Lost to White Sox (13-11), 5-4 | Comiskey Park I (1-2) | 15-8 | Lost 2 |
| » Starters: Mudcat Grant vs Billy Pierce | First | -- |
| » Lost to White Sox (14-11), 5-0 | Comiskey Park I (1-3) | 15-9 | Lost 3 |
| » Starters: Mike Garcia vs Early Wynn | First | -- |
| Tuesday, May 12 |
| » Defeated Yankees (11-14), 7-6 | Yankee Stadium (1-0) | 16-9 | |
| » Starters: Cal McLish vs Art Ditmar | First | -- |
| Friday, May 15 |
| » Defeated Red Sox (12-16), 4-3 | Fenway Park (1-0) | 17-9 | Won 2 |
| » Starters: Mudcat Grant vs Tom Brewer | First | -- |
| Saturday, May 16 |
| » Defeated Red Sox (12-17), 12-6 | Fenway Park (2-0) | 18-9 | Won 3 |
| » Starters: Herb Score vs Frank Baumann | First | -- |
| Future Indian Mitch Webster is born in Larned, KS. |
| Sunday, May 17 |
| » Lost to Orioles (18-13), 8-7 | Memorial Stadium (0-1) | 18-10 | |
| » Starters: Cal McLish vs Arnie Portocarrero | First | -- |
| » Defeated Orioles (18-14), 8-3 | Memorial Stadium (1-1) | 19-10 | |
| » Starters: Gary Bell vs Milt Pappas | First | -- |
| Monday, May 18 |
| » Lost to Orioles (19-14), 3-0 | Memorial Stadium (1-2) | 19-11 | |
| » Starters: Don Ferrarese vs Hal Brown | Second | 1½ out |
| Tuesday, May 19 |
| » Defeated Senators (17-19), 5-2 | Griffith Stadium (1-0) | 20-11 | |
| » Starters: Mudcat Grant vs Hal Griggs | First | -- |
| Wednesday, May 20 |
| » Defeated Senators (17-20), 5-3 | Griffith Stadium (2-0) | 21-11 | Won 2 |
| » Starters: Herb Score vs Russ Kemmerer | First | -- |
| Friday, May 22 |
| » Defeated Tigers (13-21), 1-0 | Cleveland Stadium (10-6) | 22-11 | Won 3 |
| » Starters: Paul Foytack vs Gary Bell | First | -- |
| Saturday, May 23 |
| » Lost to Tigers (14-21), 6-4 | Cleveland Stadium (10-7) | 22-12 | |
| » Starters: Jim Bunning vs Cal McLish | First | -- |
| Sunday, May 24 |
| » Defeated Tigers (14-22), 3-2 | Cleveland Stadium (11-7) | 23-12 | |
| » Starters: Don Mossi vs Herb Score | First | -- |
| » Lost to Tigers (15-22), 6-3 | Cleveland Stadium (11-8) | 23-13 | |
| » Starters: Frank Lary vs Mike Garcia | First | -- |
| Tuesday, May 26 |
| » Defeated White Sox (23-16), 3-0 | Comiskey Park I (2-3) | 24-13 | |
| » Starters: Don Ferrarese vs Dick Donovan | First | -- |
| Wednesday, May 27 |
| » Lost to White Sox (24-16), 5-1 | Comiskey Park I (2-4) | 24-14 | |
| » Starters: Gary Bell vs Early Wynn | First | -- |
| Future Indian Ron Tingley is born in Presque Isle, ME. |
| Thursday, May 28 |
| » Lost to Athletics (18-20), 7-2 | Cleveland Stadium (11-9) | 24-15 | Lost 2 |
| » Starters: Bud Daley vs Mudcat Grant | First | -- |
| Former Indian Ken Penner dies in Sacramento, CA at the age of 64. |
| Saturday, May 30 |
| » Defeated Athletics (18-21), 3-2 | Cleveland Stadium (12-9) | 25-15 | |
| » Starters: Johnny Kucks vs Herb Score | First | -- |
| » Lost to Athletics (19-21), 3-1 | Cleveland Stadium (12-10) | 25-16 | |
| » Starters: Rip Coleman vs Cal McLish | First | -- |
| Sunday, May 31 |
| » Lost to Tigers (20-23), 7-4 | Tiger Stadium (3-1) | 25-17 | Lost 2 |
| » Starters: Don Ferrarese vs Jerry Davie | First | -- |
| Monday, June 1 |
| » Lost to Tigers (21-23), 3-1 | Tiger Stadium (3-2) | 25-18 | Lost 3 |
| » Starters: Gary Bell vs Paul Foytack | First | -- |
| Tuesday, June 2 |
| » Lost to Senators (22-26), 3-2 | Cleveland Stadium (12-11) | 25-19 | Lost 4 |
| » Starters: Pedro Ramos vs Mudcat Grant | First | -- |
| Wednesday, June 3 |
| » Lost to Senators (23-26), 4-0 | Cleveland Stadium (12-12) | 25-20 | Lost 5 |
| » Starters: Bill Fischer vs Herb Score | First | -- |
| Friday, June 5 |
| » Lost to Yankees (22-24), 11-2 | Cleveland Stadium (12-13) | 25-21 | Lost 6 |
| » Starters: Art Ditmar vs Gary Bell | Second | 1½ out |
| Saturday, June 6 |
| » Lost to Yankees (23-24), 2-1 | Cleveland Stadium (12-14) | 25-22 | Lost 7 |
| » Starters: Bob Turley vs Don Ferrarese | Second | 1½ out |
| Future Indian Doug Frobel is born in Ottawa, ON. |
| Sunday, June 7 |
| » Defeated Yankees (23-25), 7-5 | Cleveland Stadium (13-14) | 26-22 | |
| » Starters: Don Larsen vs Herb Score | Third | 1½ out |
| » Lost to Yankees (24-25), 4-3 | Cleveland Stadium (13-15) | 26-23 | |
| » Starters: Duke Maas vs Cal McLish | Third | 1½ out |
| » Major-league debuts: Jim Bronstad (Yankees) |
| Tuesday, June 9 |
| » Lost to Orioles (29-24), 7-3 | Memorial Stadium (1-3) | 26-24 | Lost 2 |
| » Starters: Mudcat Grant vs Billy O'Dell | Second | 1½ out |
| Wednesday, June 10 |
| » Defeated Orioles (29-25), 11-8 | Memorial Stadium (2-3) | 27-24 | |
| » Starters: Gary Bell vs Jerry Walker | Third | 1½ out |
| Thursday, June 11 |
| » Defeated Orioles (29-26), 2-1 | Memorial Stadium (3-3) | 28-24 | Won 2 |
| » Starters: Don Ferrarese vs Milt Pappas | Second | 1½ out |
| Saturday, June 13 |
| » Defeated Senators (24-32), 8-7 | Griffith Stadium (3-0) | 29-24 | Won 3 |
| » Starters: Mike Garcia vs Pedro Ramos | Second | 1½ out |
| Sunday, June 14 |
| » Defeated Senators (24-33), 9-5 | Griffith Stadium (4-0) | 30-24 | Won 4 |
| » Starters: Mudcat Grant vs Russ Kemmerer | Second | 1½ out |
| » Defeated Senators (24-34), 12-6 | Griffith Stadium (5-0) | 31-24 | Won 5 |
| » Starters: Herb Score vs Bill Fischer | Second | 1½ out |
| Monday, June 15 |
| » Defeated Red Sox (25-33), 5-1 | Fenway Park (3-0) | 32-24 | Won 6 |
| » Starters: Gary Bell vs Bill Monbouquette | First | -- |
| Tuesday, June 16 |
| » Defeated Red Sox (25-34), 4-1 | Fenway Park (4-0) | 33-24 | Won 7 |
| » Starters: Cal McLish vs Ted Wills | First | -- |
| Thursday, June 18 |
| » Lost to Red Sox (26-34), 7-6 | Fenway Park (4-1) | 33-25 | |
| » Starters: Bobby Locke vs Frank Sullivan | First | -- |
| » Major-league debuts: Larry Locke (Indians) |
| Friday, June 19 |
| » Lost to Yankees (31-29), 3-2 | Yankee Stadium (1-1) | 33-26 | Lost 2 |
| » Starters: Gary Bell vs Whitey Ford | First | -- |
| Saturday, June 20 |
| » Lost to Yankees (32-29), 10-2 | Yankee Stadium (1-2) | 33-27 | Lost 3 |
| » Starters: Herb Score vs Duke Maas | First | -- |
| Sunday, June 21 |
| » Defeated Yankees (32-30), 4-2 | Yankee Stadium (2-2) | 34-27 | |
| » Starters: Cal McLish vs Art Ditmar | First | -- |
| » Defeated Yankees (32-31), 5-4 | Yankee Stadium (3-2) | 35-27 | Won 2 |
| » Starters: Mudcat Grant vs Don Larsen | First | -- |
| Tuesday, June 23 |
| » Lost to Orioles (35-31), 5-1 | Cleveland Stadium (13-16) | 35-28 | |
| » Starters: Milt Pappas vs Gary Bell | First | -- |
| Wednesday, June 24 |
| » Lost to Orioles (36-31), 7-4 | Cleveland Stadium (13-17) | 35-29 | Lost 2 |
| » Starters: Hal Brown vs Herb Score | First | -- |
| Thursday, June 25 |
| » Defeated Orioles (36-32), 3-2 | Cleveland Stadium (14-17) | 36-29 | |
| » Starters: Hoyt Wilhelm vs Bobby Locke | First | -- |
| Friday, June 26 |
| » Defeated Red Sox (30-37), 11-5 | Cleveland Stadium (15-17) | 37-29 | Won 2 |
| » Starters: Jerry Casale vs Cal McLish | First | -- |
| Saturday, June 27 |
| » Lost to Red Sox (31-37), 6-4 | Cleveland Stadium (15-18) | 37-30 | |
| » Starters: Frank Sullivan vs Mudcat Grant | First | -- |
| Sunday, June 28 |
| » Defeated Red Sox (31-38), 5-4 | Cleveland Stadium (16-18) | 38-30 | |
| » Starters: Ike Delock vs Gary Bell | First | -- |
| » Defeated Red Sox (31-39), 1-0 | Cleveland Stadium (17-18) | 39-30 | Won 2 |
| » Starters: Ted Wills vs Herb Score | First | -- |
| Tuesday, June 30 |
| » Defeated White Sox (39-33), 3-1 | Cleveland Stadium (18-18) | 40-30 | Won 3 |
| » Starters: Billy Pierce vs Cal McLish | First | -- |
| Wednesday, July 1 |
| » Lost to White Sox (40-33), 6-5 | Cleveland Stadium (18-19) | 40-31 | |
| » Starters: Barry Latman vs Mudcat Grant | First | -- |
| Thursday, July 2 |
| » Lost to Athletics (32-40), 6-4 | Municipal Stadium (2-1) | 40-32 | Lost 2 |
| » Starters: Gary Bell vs Ray Herbert | First | -- |
| Friday, July 3 |
| » Defeated Athletics (32-41), 8-4 | Municipal Stadium (3-1) | 41-32 | |
| » Starters: Herb Score vs Howie Reed | First | -- |
| Saturday, July 4 |
| » Defeated Tigers (40-38), 6-1 | Tiger Stadium (4-2) | 42-32 | Won 2 |
| » Starters: Cal McLish vs Frank Lary | First | -- |
| » Defeated Tigers (40-39), 12-9 | Tiger Stadium (5-2) | 43-32 | Won 3 |
| » Starters: Bobby Locke vs Ray Narleski | First | -- |
| Sunday, July 5 |
| » Defeated Tigers (40-40), 5-4 | Tiger Stadium (6-2) | 44-32 | Won 4 |
| » Starters: Mike Garcia vs Paul Foytack | First | -- |
| Thursday, July 9 |
| » Lost to White Sox (44-35), 4-3 | Comiskey Park I (2-5) | 44-33 | |
| » Starters: Herb Score vs Billy Pierce | First | -- |
| Friday, July 10 |
| » Defeated White Sox (44-36), 8-4 | Comiskey Park I (3-5) | 45-33 | |
| » Starters: Cal McLish vs Early Wynn | First | -- |
| Saturday, July 11 |
| » Defeated Tigers (41-43), 8-7 | Cleveland Stadium (19-19) | 46-33 | Won 2 |
| » Starters: Don Mossi vs Mike Garcia | First | -- |
| Sunday, July 12 |
| » Lost to Tigers (42-43), 6-2 | Cleveland Stadium (19-20) | 46-34 | |
| » Starters: Paul Foytack vs Bobby Locke | First | -- |
| » Defeated Tigers (42-44), 8-4 | Cleveland Stadium (20-20) | 47-34 | |
| » Starters: Tom Morgan vs Al Cicotte | First | -- |
| Tuesday, July 14 |
| » Lost to Yankees (42-43), 1-0 | Yankee Stadium (3-3) | 47-35 | |
| » Starters: Herb Score vs Whitey Ford | First | -- |
| Thursday, July 16 |
| » Lost to Yankees (43-43), 7-5 | Yankee Stadium (3-4) | 47-36 | Lost 2 |
| » Starters: Cal McLish vs Art Ditmar | Second | 1 out |
| » Lost to Yankees (44-43), 4-0 | Yankee Stadium (3-5) | 47-37 | Lost 3 |
| » Starters: Bob Smith vs Bobby Shantz | Second | 1 out |
| Former Indian Bob Coleman dies in Boston, MA at the age of 69. |
| Friday, July 17 |
| » Defeated Red Sox (39-48), 8-7 | Fenway Park (5-1) | 48-37 | |
| » Starters: Bobby Locke vs Ike Delock | Second | 1 out |
| Saturday, July 18 |
| » Defeated Red Sox (39-49), 7-5 | Fenway Park (6-1) | 49-37 | Won 2 |
| » Starters: Herb Score vs Frank Sullivan | Second | 1 out |
| Sunday, July 19 |
| » Lost to Red Sox (40-49), 6-5 | Fenway Park (6-2) | 49-38 | |
| » Starters: Gary Bell vs Bill Monbouquette | First | -- |
| » Defeated Red Sox (40-50), 5-3 | Fenway Park (7-2) | 50-38 | |
| » Starters: Mudcat Grant vs Frank Baumann | First | -- |
| Tuesday, July 21 |
| » Defeated Yankees (46-46), 5-1 | Cleveland Stadium (21-20) | 51-38 | Won 2 |
| » Starters: Bobby Shantz vs Cal McLish | First | -- |
| Future Indian Rich Barnes is born in Palm Beach, FL. Former Indian Bill Hoffer dies in Cedar Rapids, IA at the age of 89 |
| Wednesday, July 22 |
| » Lost to Yankees (47-46), 8-5 | Cleveland Stadium (21-21) | 51-39 | |
| » Starters: Duke Maas vs Herb Score | Second | 1 out |
| Thursday, July 23 |
| » Defeated Yankees (47-47), 8-5 | Cleveland Stadium (22-21) | 52-39 | |
| » Starters: Ralph Terry vs Bob Smith | Second | ½ out |
| Friday, July 24 |
| » Defeated Senators (43-51), 5-2 | Cleveland Stadium (23-21) | 53-39 | Won 2 |
| » Starters: Camilo Pascual vs Gary Bell | Second | ½ out |
| Saturday, July 25 |
| » Defeated Senators (43-52), 8-1 | Cleveland Stadium (24-21) | 54-39 | Won 3 |
| » Starters: Bill Fischer vs Cal McLish | Second | ½ out |
| Sunday, July 26 |
| » Defeated Senators (43-53), 9-0 | Cleveland Stadium (25-21) | 55-39 | Won 4 |
| » Starters: Hal Griggs vs Jim Perry | First | -- |
| » Defeated Senators (43-54), 4-3 | Cleveland Stadium (26-21) | 56-39 | Won 5 |
| » Starters: Pedro Ramos vs Bobby Locke | First | -- |
| Monday, July 27 |
| » Lost to Red Sox (41-55), 4-0 | Cleveland Stadium (26-22) | 56-40 | |
| » Starters: Jerry Casale vs Herb Score | First | -- |
| Tuesday, July 28 |
| » Defeated Red Sox (41-56), 5-2 | Cleveland Stadium (27-22) | 57-40 | |
| » Starters: Frank Sullivan vs Gary Bell | Second | ½ out |
| » Lost to Red Sox (42-56), 8-4 | Cleveland Stadium (27-23) | 57-41 | |
| » Starters: Bill Monbouquette vs Don Ferrarese | Second | ½ out |
| » Major-league debuts: Jim Mahoney and Earl Wilson (Red Sox) |
| Wednesday, July 29 |
| » Lost to Red Sox (43-56), 4-1 | Cleveland Stadium (27-24) | 57-42 | Lost 2 |
| » Starters: Al Schroll vs Cal McLish | Second | 1 out |
| Thursday, July 30 |
| » Defeated Red Sox (43-57), 4-3 | Cleveland Stadium (28-24) | 58-42 | |
| » Starters: Tom Brewer vs Mudcat Grant | Second | 1 out |
| Friday, July 31 |
| » Defeated Orioles (51-52), 5-4 | Cleveland Stadium (29-24) | 59-42 | Won 2 |
| » Starters: Arnie Portocarrero vs Jim Perry | Second | 1 out |
| Saturday, August 1 |
| » Lost to Orioles (52-52), 5-2 | Cleveland Stadium (29-25) | 59-43 | |
| » Starters: Hal Brown vs Bobby Locke | Second | 2 out |
| Sunday, August 2 |
| » Lost to Orioles (53-52), 5-4 | Cleveland Stadium (29-26) | 59-44 | Lost 2 |
| » Starters: Hoyt Wilhelm vs Cal McLish | Second | 3 out |
| » Defeated Orioles (53-53), 6-3 | Cleveland Stadium (30-26) | 60-44 | |
| » Starters: Milt Pappas vs Gary Bell | Second | 3 out |
| Monday, August 3 |
| Future Indian Mike Jeffcoat is born in Pine Bluff, AR. |
| Tuesday, August 4 |
| » Defeated Senators (43-63), 8-2 | Griffith Stadium (6-0) | 61-44 | Won 2 |
| » Starters: Jim Perry vs Bill Fischer | Second | 2 out |
| Wednesday, August 5 |
| » Defeated Senators (43-64), 7-3 | Griffith Stadium (7-0) | 62-44 | Won 3 |
| » Starters: Mudcat Grant vs Pedro Ramos | Second | 2 out |
| » Lost to Senators (44-64), 9-0 | Griffith Stadium (7-1) | 62-45 | |
| » Starters: Cal McLish vs Tex Clevenger | Second | 2 out |
| Thursday, August 6 |
| » Defeated Senators (44-65), 5-2 | Griffith Stadium (8-1) | 63-45 | |
| » Starters: Gary Bell vs Russ Kemmerer | Second | 1½ out |
| Friday, August 7 |
| » Defeated Orioles (55-55), 8-5 | Memorial Stadium (4-3) | 64-45 | Won 2 |
| » Starters: Herb Score vs Jerry Walker | Second | 1½ out |
| Sunday, August 9 |
| » Lost to Orioles (56-55), 4-3 | Memorial Stadium (4-4) | 64-46 | |
| » Starters: Jim Perry vs Milt Pappas | Second | 3 out |
| Monday, August 10 |
| » Defeated Athletics (52-59), 6-4 | Municipal Stadium (4-1) | 65-46 | |
| » Starters: Cal McLish vs Ray Herbert | Second | 2½ out |
| Tuesday, August 11 |
| » Lost to Athletics (53-59), 7-3 | Municipal Stadium (4-2) | 65-47 | |
| » Starters: Mudcat Grant vs Bud Daley | Second | 2½ out |
| Wednesday, August 12 |
| » Defeated Athletics (53-60), 9-4 | Municipal Stadium (5-2) | 66-47 | |
| » Starters: Gary Bell vs Johnny Kucks | Second | 2½ out |
| Former Indian Johnny Burnett dies in Tampa, FL at the age of 55. |
| Thursday, August 13 |
| » Defeated Athletics (53-61), 7-5 | Municipal Stadium (6-2) | 67-47 | Won 2 |
| » Starters: Jack Harshman vs John Tsitouris | Second | 2½ out |
| Friday, August 14 |
| » Lost to Tigers (56-60), 11-1 | Tiger Stadium (6-3) | 67-48 | |
| » Starters: Cal McLish vs Frank Lary | Second | 3½ out |
| Saturday, August 15 |
| » Lost to Tigers (57-60), 9-6 | Tiger Stadium (6-4) | 67-49 | Lost 2 |
| » Starters: Herb Score vs Jim Bunning | Second | 3½ out |
| Monday, August 17 |
| » Lost to Tigers (58-60), 5-4 | Tiger Stadium (6-5) | 67-50 | Lost 3 |
| » Starters: Gary Bell vs Paul Foytack | Second | 3½ out |
| Future Indian Jeff Moronko is born in Houston, TX. |
| Tuesday, August 18 |
| » Lost to Senators (49-69), 11-4 | Cleveland Stadium (30-27) | 67-51 | Lost 4 |
| » Starters: Russ Kemmerer vs Jim Perry | Second | 4½ out |
| Wednesday, August 19 |
| » Defeated Senators (49-70), 5-4 | Cleveland Stadium (31-27) | 68-51 | |
| » Starters: Bill Fischer vs Cal McLish | Second | 3½ out |
| Thursday, August 20 |
| » Defeated Senators (49-71), 6-1 | Cleveland Stadium (32-27) | 69-51 | Won 2 |
| » Starters: Pedro Ramos vs Mudcat Grant | Second | 2½ out |
| Friday, August 21 |
| » Defeated Orioles (59-60), 5-0 | Cleveland Stadium (33-27) | 70-51 | Won 3 |
| » Starters: Hal Brown vs Jack Harshman | Second | 2½ out |
| Saturday, August 22 |
| » Defeated Orioles (59-61), 4-2 | Cleveland Stadium (34-27) | 71-51 | Won 4 |
| » Starters: Milt Pappas vs Gary Bell | Second | 2½ out |
| Sunday, August 23 |
| » Defeated Red Sox (57-66), 1-0 | Cleveland Stadium (35-27) | 72-51 | Won 5 |
| » Starters: Tom Brewer vs Jim Perry | Second | 1½ out |
| » Defeated Red Sox (57-67), 6-2 | Cleveland Stadium (36-27) | 73-51 | Won 6 |
| » Starters: Al Schroll vs Mike Garcia | Second | 1½ out |
| Tuesday, August 25 |
| » Defeated Yankees (62-64), 6-3 | Cleveland Stadium (37-27) | 74-51 | Won 7 |
| » Starters: Whitey Ford vs Cal McLish | Second | 2 out |
| Wednesday, August 26 |
| » Defeated Yankees (62-65), 5-4 | Cleveland Stadium (38-27) | 75-51 | Won 8 |
| » Starters: Duke Maas vs Gary Bell | Second | 1 out |
| Friday, August 28 |
| » Lost to White Sox (77-49), 7-3 | Cleveland Stadium (38-28) | 75-52 | |
| » Starters: Bob Shaw vs Jack Harshman | Second | 2½ out |
| Saturday, August 29 |
| » Lost to White Sox (78-49), 2-0 | Cleveland Stadium (38-29) | 75-53 | Lost 2 |
| » Starters: Dick Donovan vs Jim Perry | Second | 3½ out |
| Sunday, August 30 |
| » Lost to White Sox (79-49), 6-3 | Cleveland Stadium (38-30) | 75-54 | Lost 3 |
| » Starters: Early Wynn vs Cal McLish | Second | 5½ out |
| » Lost to White Sox (80-49), 9-4 | Cleveland Stadium (38-31) | 75-55 | Lost 4 |
| » Starters: Barry Latman vs Gary Bell | Second | 5½ out |
| Wednesday, September 2 |
| » Defeated Athletics (59-71), 6-3 | Cleveland Stadium (39-31) | 76-55 | |
| » Starters: Ned Garver vs Herb Score | Second | 5½ out |
| Friday, September 4 |
| » Lost to White Sox (83-50), 3-2 | Comiskey Park I (3-6) | 76-56 | |
| » Starters: Jim Perry vs Early Wynn | Second | 6½ out |
| Saturday, September 5 |
| » Defeated White Sox (83-51), 6-5 | Comiskey Park I (4-6) | 77-56 | |
| » Starters: Cal McLish vs Bob Shaw | Second | 5½ out |
| Sunday, September 6 |
| » Defeated White Sox (83-52), 2-1 | Comiskey Park I (5-6) | 78-56 | Won 2 |
| » Starters: Mudcat Grant vs Dick Donovan | Second | 4½ out |
| Monday, September 7 |
| » Defeated Tigers (69-68), 15-14 | Cleveland Stadium (40-31) | 79-56 | Won 3 |
| » Starters: Paul Foytack vs Mike Garcia | Second | 4½ out |
| » Defeated Tigers (69-69), 6-5 | Cleveland Stadium (41-31) | 80-56 | Won 4 |
| » Starters: Ray Narleski vs Bob Smith | Second | 4½ out |
| Wednesday, September 9 |
| » Defeated Orioles (66-70), 3-2 | Memorial Stadium (5-4) | 81-56 | Won 5 |
| » Starters: Jack Harshman vs Milt Pappas | Second | 4½ out |
| » Defeated Orioles (66-71), 4-1 | Memorial Stadium (6-4) | 82-56 | Won 6 |
| » Starters: Jim Perry vs Hal Brown | Second | 4½ out |
| Thursday, September 10 |
| » Lost to Orioles (67-71), 6-1 | Memorial Stadium (6-5) | 82-57 | |
| » Starters: Cal McLish vs Hoyt Wilhelm | Second | 4½ out |
| Friday, September 11 |
| » Lost to Senators (58-83), 5-4 | Griffith Stadium (8-2) | 82-58 | Lost 2 |
| » Starters: Mudcat Grant vs Pedro Ramos | Second | 4 out |
| Saturday, September 12 |
| » Defeated Senators (58-84), 7-2 | Griffith Stadium (9-2) | 83-58 | |
| » Starters: Gary Bell vs Russ Kemmerer | Second | 4 out |
| Sunday, September 13 |
| » Lost to Yankees (72-70), 2-1 | Yankee Stadium (3-6) | 83-59 | |
| » Starters: Jack Harshman vs Bob Turley | Second | 5½ out |
| » Lost to Yankees (73-70), 1-0 | Yankee Stadium (3-7) | 83-60 | Lost 2 |
| » Starters: Jim Perry vs Duke Maas | Second | 5½ out |
| Monday, September 14 |
| » Defeated Yankees (73-71), 8-5 | Yankee Stadium (4-7) | 84-60 | |
| » Starters: Cal McLish vs Art Ditmar | Second | 4½ out |
| Tuesday, September 15 |
| » Lost to Red Sox (68-77), 1-0 | Fenway Park (7-3) | 84-61 | |
| » Starters: Mudcat Grant vs Tom Brewer | Second | 5½ out |
| Wednesday, September 16 |
| » Lost to Red Sox (69-77), 6-5 | Fenway Park (7-4) | 84-62 | Lost 2 |
| » Starters: Gary Bell vs Jerry Casale | Second | 5½ out |
| Friday, September 18 |
| » Defeated Athletics (63-83), 11-2 | Municipal Stadium (7-2) | 85-62 | |
| » Starters: Jim Perry vs Bud Daley | Second | 5½ out |
| Saturday, September 19 |
| » Defeated Athletics (63-84), 13-7 | Municipal Stadium (8-2) | 86-62 | Won 2 |
| » Starters: Jack Harshman vs Johnny Kucks | Second | 4½ out |
| » Major-league debuts: Gordy Coleman (Indians) |
| Sunday, September 20 |
| » Defeated Athletics (63-85), 4-3 | Municipal Stadium (9-2) | 87-62 | Won 3 |
| » Starters: Cal McLish vs Ned Garver | Second | 3½ out |
| Tuesday, September 22 |
| » Lost to White Sox (92-59), 4-2 | Cleveland Stadium (41-32) | 87-63 | |
| » Starters: Early Wynn vs Jim Perry | Second | 4½ out |
| Friday, September 25 |
| » Defeated Athletics (64-87), 8-2 | Cleveland Stadium (42-32) | 88-63 | |
| » Starters: Johnny Kucks vs Jake Striker | Second | 3 out |
| » Defeated Athletics (64-88), 8-7 | Cleveland Stadium (43-32) | 89-63 | Won 2 |
| » Starters: Bud Daley vs Cal McLish | Second | 3 out |
| » Major-league debuts: Jake Striker (Indians) |
| Saturday, September 26 |
| » Lost to Athletics (65-88), 8-4 | Cleveland Stadium (43-33) | 89-64 | |
| » Starters: Ken Johnson vs John Briggs | Second | 4 out |
| Sunday, September 27 |
| » Lost to Athletics (66-88), 6-5 | Cleveland Stadium (43-34) | 89-65 | Lost 2 |
| » Starters: Ned Garver vs Herb Score | Second | |
