| Monday, January 5 |
| Future Cardinal Milt Thompson is born in Washington, DC. |
| Wednesday, January 14 |
| Future Cardinal Jeff Keener is born in Pana, IL. |
| Wednesday, January 21 |
| Future Cardinal Jose Uribe is born in San Cristobal, D.R. |
| Tuesday, January 27 |
| Future Cardinal Greg Bargar is born in Inglewood, CA. |
| Wednesday, February 4 |
| Future Cardinal Pat Perry is born in Taylorville, IL. |
| Wednesday, February 25 |
| Future Cardinal Ken Dayley is born in Jerome, ID. |
| Thursday, March 5 |
| Future Cardinal Andy Rincon is born in Monterey Park, CA. |
| Friday, April 10 |
| » Lost to Giants (1-0), 6-5 | Sportsman's Park III (0-1) | 0-1 | |
| » Starters: Johnny Antonelli vs Larry Jackson | Fourth | 1 out |
| » Major-league debuts: Gary Blaylock (Cardinals) |
| Saturday, April 11 |
| » Lost to Giants (2-0), 5-2 | Sportsman's Park III (0-2) | 0-2 | Lost 2 |
| » Starters: Sam Jones vs Ernie Broglio | Fifth | 2 out |
| » Major-league debuts: Ernie Broglio and Howie Nunn (Cardinals) |
| Sunday, April 12 |
| » Lost to Giants (3-0), 6-3 | Sportsman's Park III (0-3) | 0-3 | Lost 3 |
| » Starters: Mike McCormick vs Vinegar Bend Mizell | Fifth | 3 out |
| Tuesday, April 14 |
| » Defeated Dodgers (1-2), 6-2 | Los Angeles Memorial Coliseum (1-0) | 1-3 | |
| » Starters: Lindy McDaniel vs Johnny Podres | Sixth | 2½ out |
| Wednesday, April 15 |
| » Lost to Dodgers (2-2), 5-0 | Los Angeles Memorial Coliseum (1-1) | 1-4 | |
| » Starters: Larry Jackson vs Don Drysdale | Sixth | 3 out |
| Thursday, April 16 |
| » Lost to Dodgers (3-2), 7-6 | Los Angeles Memorial Coliseum (1-2) | 1-5 | Lost 2 |
| » Starters: Ernie Broglio vs Sandy Koufax | Sixth | 4 out |
| Friday, April 17 |
| » Defeated Giants (4-3), 4-1 | Seals Stadium (1-0) | 2-5 | |
| » Starters: Vinegar Bend Mizell vs Mike McCormick | Seventh | 3½ out |
| Saturday, April 18 |
| » Lost to Giants (5-3), 8-1 | Seals Stadium (1-1) | 2-6 | |
| » Starters: Lindy McDaniel vs Jack Sanford | Sixth | 3½ out |
| Sunday, April 19 |
| » Lost to Giants (6-3), 3-1 | Seals Stadium (1-2) | 2-7 | Lost 2 |
| » Starters: Larry Jackson vs Johnny Antonelli | Seventh | 4 out |
| Tuesday, April 21 |
| » Lost to Cubs (5-4), 1-0 | Wrigley Field (0-1) | 2-8 | Lost 3 |
| » Starters: Gary Blaylock vs Glen Hobbie | Seventh | 5 out |
| Wednesday, April 22 |
| » Defeated Cubs (5-5), 8-2 | Wrigley Field (1-1) | 3-8 | |
| » Starters: Vinegar Bend Mizell vs Taylor Phillips | Eighth | 5 out |
| Thursday, April 23 |
| » Lost to Cubs (6-5), 6-1 | Wrigley Field (1-2) | 3-9 | |
| » Starters: Lindy McDaniel vs Moe Drabowsky | Eighth | 5 out |
| Friday, April 24 |
| » Lost to Dodgers (8-4), 3-2 | Sportsman's Park III (0-4) | 3-10 | Lost 2 |
| » Starters: Johnny Podres vs Larry Jackson | Eighth | 6 out |
| Saturday, April 25 |
| » Defeated Dodgers (8-5), 6-5 | Sportsman's Park III (1-4) | 4-10 | |
| » Starters: Don Drysdale vs Gary Blaylock | Seventh | 5 out |
| Sunday, April 26 |
| » Lost to Dodgers (9-5), 17-11 | Sportsman's Park III (1-5) | 4-11 | |
| » Starters: Sandy Koufax vs Vinegar Bend Mizell | Seventh | 5½ out |
| » Major-league debuts: Gene Snyder (Dodgers) |
| Wednesday, April 29 |
| » Lost to Braves (8-4), 9-3 | County Stadium (0-1) | 4-12 | Lost 2 |
| » Starters: Larry Jackson vs Lew Burdette | Eighth | 6 out |
| Thursday, April 30 |
| » Lost to Braves (9-4), 1-0 | County Stadium (0-2) | 4-13 | Lost 3 |
| » Starters: Alex Kellner vs Warren Spahn | Seventh | 7 out |
| Friday, May 1 |
| » Defeated Pirates (6-9), 7-6 | Forbes Field (1-0) | 5-13 | |
| » Starters: Vinegar Bend Mizell vs Bob Friend | Eighth | 6 out |
| Saturday, May 2 |
| » Lost to Pirates (7-9), 2-1 | Forbes Field (1-1) | 5-14 | |
| » Starters: Lindy McDaniel vs Harvey Haddix | Seventh | 6½ out |
| Sunday, May 3 |
| » Lost to Pirates (8-9), 4-3 | Forbes Field (1-2) | 5-15 | Lost 2 |
| » Starters: Larry Jackson vs Vern Law | Sixth | 6½ out |
| » Defeated Pirates (8-10), 3-1 | Forbes Field (2-2) | 6-15 | |
| » Starters: Gary Blaylock vs Bennie Daniels | Sixth | 6½ out |
| Tuesday, May 5 |
| » Lost to Phillies (9-10), 8-7 | Shibe Park (0-1) | 6-16 | |
| » Starters: Vinegar Bend Mizell vs Robin Roberts | Seventh | 7 out |
| Former Cardinal Verne Clemons dies in Bay Pines, FL at the age of 68. |
| Wednesday, May 6 |
| » Defeated Phillies (9-11), 8-7 | Shibe Park (1-1) | 7-16 | |
| » Starters: Alex Kellner vs Ray Semproch | Seventh | 7 out |
| Thursday, May 7 |
| » Defeated Cubs (12-12), 4-3 | Sportsman's Park III (2-5) | 8-16 | Won 2 |
| » Starters: Moe Drabowsky vs Lindy McDaniel | Eighth | 6½ out |
| Friday, May 8 |
| » Lost to Cubs (13-12), 3-2 | Sportsman's Park III (2-6) | 8-17 | |
| » Starters: Bob Anderson vs Gary Blaylock | Eighth | 6½ out |
| Saturday, May 9 |
| » Defeated Cubs (13-13), 11-1 | Sportsman's Park III (3-6) | 9-17 | |
| » Starters: Glen Hobbie vs Larry Jackson | Eighth | 6½ out |
| Sunday, May 10 |
| » Lost to Cubs (14-13), 10-9 | Sportsman's Park III (3-7) | 9-18 | |
| » Starters: Dave Hillman vs Vinegar Bend Mizell | Eighth | 6½ out |
| » Defeated Cubs (14-14), 8-7 | Sportsman's Park III (4-7) | 10-18 | |
| » Starters: John Buzhardt vs Ernie Broglio | Eighth | 6½ out |
| Tuesday, May 12 |
| » Defeated Reds (14-12), 7-4 | Sportsman's Park III (5-7) | 11-18 | Won 2 |
| » Starters: Brooks Lawrence vs Gary Blaylock | Eighth | 6½ out |
| Wednesday, May 13 |
| » Lost to Braves (16-10), 3-2 | Sportsman's Park III (5-8) | 11-19 | |
| » Starters: Warren Spahn vs Larry Jackson | Eighth | 7 out |
| Thursday, May 14 |
| » Lost to Braves (17-10), 8-7 | Sportsman's Park III (5-9) | 11-20 | Lost 2 |
| » Starters: Juan Pizarro vs Lindy McDaniel | Eighth | 8 out |
| Friday, May 15 |
| » Defeated Phillies (11-19), 8-2 | Sportsman's Park III (6-9) | 12-20 | |
| » Starters: Robin Roberts vs Vinegar Bend Mizell | Seventh | 7½ out |
| Saturday, May 16 |
| » Defeated Phillies (11-20), 8-2 | Sportsman's Park III (7-9) | 13-20 | Won 2 |
| » Starters: Jim Owens vs Gary Blaylock | Seventh | 7½ out |
| Monday, May 18 |
| Former Cardinal Gene Packard dies in Riverside, CA at the age of 72. |
| Tuesday, May 19 |
| » Defeated Pirates (16-18), 8-2 | Sportsman's Park III (8-9) | 14-20 | Won 3 |
| » Starters: Ron Kline vs Larry Jackson | Sixth | 8½ out |
| Wednesday, May 20 |
| » Defeated Pirates (16-19), 11-1 | Sportsman's Park III (9-9) | 15-20 | Won 4 |
| » Starters: Bob Friend vs Vinegar Bend Mizell | Seventh | 7½ out |
| Thursday, May 21 |
| » Lost to Pirates (17-19), 7-2 | Sportsman's Park III (9-10) | 15-21 | |
| » Starters: Harvey Haddix vs Lindy McDaniel | Sixth | 8 out |
| Friday, May 22 |
| » Defeated Cubs (20-19), 3-1 | Wrigley Field (2-2) | 16-21 | |
| » Starters: Gary Blaylock vs Glen Hobbie | Seventh | 8 out |
| Saturday, May 23 |
| » Defeated Cubs (20-20), 5-1 | Wrigley Field (3-2) | 17-21 | Won 2 |
| » Starters: Larry Jackson vs Dave Hillman | Seventh | 7 out |
| Sunday, May 24 |
| » Defeated Cubs (20-21), 7-3 | Wrigley Field (4-2) | 18-21 | Won 3 |
| » Starters: Vinegar Bend Mizell vs Moe Drabowsky | Sixth | 6½ out |
| Monday, May 25 |
| » Lost to Cubs (21-21), 9-4 | Sportsman's Park III (9-11) | 18-22 | |
| » Starters: Bob Anderson vs Tom Cheney | Seventh | 6½ out |
| Former Cardinal Dave Brain dies in Los Angeles, CA at the age of 81. |
| Tuesday, May 26 |
| » Major-league debuts: Joe Christopher (Pirates) |
| Wednesday, May 27 |
| » Lost to Giants (23-18), 9-4 | Seals Stadium (1-3) | 18-23 | Lost 2 |
| » Starters: Gary Blaylock vs Johnny Antonelli | Seventh | 8 out |
| Thursday, May 28 |
| » Lost to Giants (24-18), 5-4 | Seals Stadium (1-4) | 18-24 | Lost 3 |
| » Starters: Larry Jackson vs Sam Jones | Seventh | 8 out |
| Friday, May 29 |
| » Defeated Giants (24-19), 4-2 | Seals Stadium (2-4) | 19-24 | |
| » Starters: Vinegar Bend Mizell vs Jack Sanford | Seventh | 8 out |
| Saturday, May 30 |
| » Lost to Dodgers (24-23), 7-6 | Los Angeles Memorial Coliseum (1-3) | 19-25 | |
| » Starters: Tom Cheney vs Johnny Podres | Seventh | 9 out |
| Sunday, May 31 |
| » Lost to Dodgers (25-23), 5-3 | Los Angeles Memorial Coliseum (1-4) | 19-26 | Lost 2 |
| » Starters: Gary Blaylock vs Sandy Koufax | Seventh | 9½ out |
| Tuesday, June 2 |
| » Lost to Pirates (26-22), 3-0 | Forbes Field (2-3) | 19-27 | Lost 3 |
| » Starters: Larry Jackson vs Harvey Haddix | Seventh | 10 out |
| Wednesday, June 3 |
| » Lost to Pirates (27-22), 5-3 | Forbes Field (2-4) | 19-28 | Lost 4 |
| » Starters: Vinegar Bend Mizell vs Bob Friend | Seventh | 11 out |
| Thursday, June 4 |
| » Lost to Pirates (28-22), 9-3 | Forbes Field (2-5) | 19-29 | Lost 5 |
| » Starters: Ernie Broglio vs Ron Kline | Seventh | 11 out |
| Saturday, June 6 |
| » Lost to Phillies (19-30), 4-3 | Shibe Park (1-2) | 19-30 | Lost 6 |
| » Starters: Gary Blaylock vs Robin Roberts | Seventh | 10½ out |
| » Major-league debuts: Gene Oliver (Cardinals) |
| Sunday, June 7 |
| » Lost to Phillies (20-30), 11-9 | Shibe Park (1-3) | 19-31 | Lost 7 |
| » Starters: Jim Brosnan vs Ruben Gomez | Sixth | 11 out |
| » Defeated Phillies (20-31), 2-0 | Shibe Park (2-3) | 20-31 | |
| » Starters: Vinegar Bend Mizell vs Don Cardwell | Sixth | 11 out |
| Tuesday, June 9 |
| » Defeated Braves (32-21), 12-3 | Sportsman's Park III (10-11) | 21-31 | Won 2 |
| » Starters: Warren Spahn vs Larry Jackson | Sixth | 10½ out |
| Former Cardinal Frank Huelsman dies in Affton, MO at the age of 86. |
| Wednesday, June 10 |
| » Defeated Braves (32-22), 5-2 | Sportsman's Park III (11-11) | 22-31 | Won 3 |
| » Starters: Bob Rush vs Alex Kellner | Sixth | 9½ out |
| Thursday, June 11 |
| » Lost to Braves (33-22), 8-0 | Sportsman's Park III (11-12) | 22-32 | |
| » Starters: Bob Buhl vs Vinegar Bend Mizell | Seventh | 10½ out |
| Friday, June 12 |
| » Defeated Reds (27-30), 2-1 | Sportsman's Park III (12-12) | 23-32 | |
| » Starters: Brooks Lawrence vs Ernie Broglio | Seventh | 9½ out |
| Saturday, June 13 |
| » Defeated Reds (27-31), 7-0 | Sportsman's Park III (13-12) | 24-32 | Won 2 |
| » Starters: Orlando Pena vs Larry Jackson | Seventh | 9½ out |
| Sunday, June 14 |
| » Defeated Reds (27-32), 5-4 | Sportsman's Park III (14-12) | 25-32 | Won 3 |
| » Starters: Joe Nuxhall vs Gary Blaylock | Seventh | 9 out |
| » Lost to Reds (28-32), 3-2 | Sportsman's Park III (14-13) | 25-33 | |
| » Starters: Jim Brosnan vs Dick Ricketts | Seventh | 9 out |
| » Major-league debuts: Dick Ricketts (Cardinals) |
| Tuesday, June 16 |
| » Defeated Phillies (23-36), 8-1 | Sportsman's Park III (15-13) | 26-33 | |
| » Starters: Ruben Gomez vs Vinegar Bend Mizell | Seventh | 8 out |
| » Defeated Phillies (23-37), 5-2 | Sportsman's Park III (16-13) | 27-33 | Won 2 |
| » Starters: Jim Owens vs Ernie Broglio | Seventh | 8 out |
| Wednesday, June 17 |
| » Defeated Phillies (23-38), 10-4 | Sportsman's Park III (17-13) | 28-33 | Won 3 |
| » Starters: Ray Semproch vs Larry Jackson | Seventh | 6½ out |
| Friday, June 19 |
| » Lost to Pirates (36-30), 6-0 | Sportsman's Park III (17-14) | 28-34 | |
| » Starters: Vern Law vs Dick Ricketts | Seventh | 7½ out |
| Saturday, June 20 |
| » Defeated Pirates (36-31), 5-2 | Sportsman's Park III (18-14) | 29-34 | |
| » Starters: Bob Friend vs Vinegar Bend Mizell | Sixth | 7 out |
| Sunday, June 21 |
| » Defeated Pirates (36-32), 5-1 | Sportsman's Park III (19-14) | 30-34 | Won 2 |
| » Starters: Harvey Haddix vs Larry Jackson | Sixth | 7½ out |
| » Lost to Pirates (37-32), 10-8 | Sportsman's Park III (19-15) | 30-35 | |
| » Starters: Al Jackson vs Ernie Broglio | Sixth | 7½ out |
| Tuesday, June 23 |
| » Lost to Braves (39-28), 9-5 | County Stadium (0-3) | 30-36 | Lost 2 |
| » Starters: Alex Kellner vs Carl Willey | Fifth | 8½ out |
| Wednesday, June 24 |
| » Lost to Braves (40-28), 4-0 | County Stadium (0-4) | 30-37 | Lost 3 |
| » Starters: Dick Ricketts vs Joey Jay | Seventh | 9½ out |
| Thursday, June 25 |
| » Defeated Braves (40-29), 3-2 | County Stadium (1-4) | 31-37 | |
| » Starters: Vinegar Bend Mizell vs Lew Burdette | Sixth | 8½ out |
| Friday, June 26 |
| » Lost to Reds (32-38), 7-6 | Crosley Field (0-1) | 31-38 | |
| » Starters: Larry Jackson vs Don Newcombe | Seventh | 9½ out |
| Saturday, June 27 |
| » Defeated Reds (32-39), 5-0 | Crosley Field (1-1) | 32-38 | |
| » Starters: Ernie Broglio vs Jim O'Toole | Sixth | 8½ out |
| Sunday, June 28 |
| » Defeated Reds (32-40), 9-7 | Crosley Field (2-1) | 33-38 | Won 2 |
| » Starters: Marshall Bridges vs Joe Nuxhall | Sixth | 8 out |
| » Defeated Reds (32-41), 11-8 | Crosley Field (3-1) | 34-38 | Won 3 |
| » Starters: Dick Ricketts vs Willard Schmidt | Sixth | 8 out |
| Former Cardinal Joe Sugden dies in Philadelphia, PA at the age of 89. |
| Tuesday, June 30 |
| » Defeated Cubs (36-37), 4-1 | Wrigley Field (5-2) | 35-38 | Won 4 |
| » Starters: Larry Jackson vs Bob Anderson | Sixth | 7 out |
| Wednesday, July 1 |
| » Lost to Cubs (37-37), 6-5 | Wrigley Field (5-3) | 35-39 | |
| » Starters: Ernie Broglio vs John Buzhardt | Sixth | 7½ out |
| Thursday, July 2 |
| » Lost to Dodgers (44-35), 4-0 | Sportsman's Park III (19-16) | 35-40 | Lost 2 |
| » Starters: Danny McDevitt vs Dick Ricketts | Sixth | 7½ out |
| Friday, July 3 |
| » Defeated Dodgers (44-36), 3-2 | Sportsman's Park III (20-16) | 36-40 | |
| » Starters: Sandy Koufax vs Marshall Bridges | Sixth | 7½ out |
| Future Cardinal Kurt Kepshire is born in Bridgeport, CT. |
| Saturday, July 4 |
| » Lost to Giants (45-34), 10-3 | Sportsman's Park III (20-17) | 36-41 | |
| » Starters: Mike McCormick vs Larry Jackson | Sixth | 8 out |
| Sunday, July 5 |
| » Defeated Giants (45-35), 4-2 | Sportsman's Park III (21-17) | 37-41 | |
| » Starters: Jack Sanford vs Ernie Broglio | Sixth | 8 out |
| » Lost to Giants (46-35), 4-2 | Sportsman's Park III (21-18) | 37-42 | |
| » Starters: Sam Jones vs Gary Blaylock | Sixth | 8 out |
| Thursday, July 9 |
| » Lost to Phillies (30-49), 11-0 | Shibe Park (2-4) | 37-43 | Lost 2 |
| » Starters: Ernie Broglio vs Gene Conley | Sixth | 8½ out |
| » Defeated Phillies (30-50), 6-2 | Shibe Park (3-4) | 38-43 | |
| » Starters: Larry Jackson vs Robin Roberts | Sixth | 8½ out |
| » Major-league debuts: Wally Shannon (Cardinals) |
| Friday, July 10 |
| » Defeated Phillies (30-51), 9-7 | Shibe Park (4-4) | 39-43 | Won 2 |
| » Starters: Vinegar Bend Mizell vs Jim Owens | Fifth | 8½ out |
| Saturday, July 11 |
| » Defeated Phillies (30-52), 4-3 | Shibe Park (5-4) | 40-43 | Won 3 |
| » Starters: Marshall Bridges vs Don Cardwell | Fifth | 8½ out |
| Former Cardinal Frank Gilhooley dies in Toledo, OH at the age of 68. |
| Sunday, July 12 |
| » Lost to Pirates (47-40), 6-5 | Forbes Field (2-6) | 40-44 | |
| » Starters: Ernie Broglio vs Harvey Haddix | Fifth | 8 out |
| » Defeated Pirates (47-41), 8-6 | Forbes Field (3-6) | 41-44 | |
| » Starters: Dick Ricketts vs George Witt | Fifth | 8 out |
| Tuesday, July 14 |
| » Defeated Reds (37-49), 6-5 | Sportsman's Park III (22-18) | 42-44 | Won 2 |
| » Starters: Don Newcombe vs Larry Jackson | Fifth | 7 out |
| Wednesday, July 15 |
| » Lost to Reds (38-49), 11-5 | Sportsman's Park III (22-19) | 42-45 | |
| » Starters: Jim O'Toole vs Vinegar Bend Mizell | Sixth | 7½ out |
| Thursday, July 16 |
| » Lost to Reds (39-49), 7-5 | Sportsman's Park III (22-20) | 42-46 | Lost 2 |
| » Starters: Jim Brosnan vs Ernie Broglio | Sixth | 8 out |
| Friday, July 17 |
| » Defeated Braves (46-39), 4-3 | Sportsman's Park III (23-20) | 43-46 | |
| » Starters: Warren Spahn vs Larry Jackson | Sixth | 8 out |
| » Major-league debuts: Lee Maye (Braves) |
| Saturday, July 18 |
| » Defeated Braves (46-40), 6-5 | Sportsman's Park III (24-20) | 44-46 | Won 2 |
| » Starters: Bob Rush vs Dick Ricketts | Sixth | 8 out |
| Sunday, July 19 |
| » Defeated Braves (46-41), 9-5 | Sportsman's Park III (25-20) | 45-46 | Won 3 |
| » Starters: Juan Pizarro vs Vinegar Bend Mizell | Sixth | 7 out |
| Monday, July 20 |
| » Defeated Cubs (45-46), 2-0 | Sportsman's Park III (26-20) | 46-46 | Won 4 |
| » Starters: Glen Hobbie vs Ernie Broglio | Fifth | 6 out |
| Tuesday, July 21 |
| » Lost to Cubs (46-46), 8-2 | Sportsman's Park III (26-21) | 46-47 | |
| » Starters: Art Ceccarelli vs Larry Jackson | Sixth | 6 out |
| Wednesday, July 22 |
| » Lost to Giants (53-41), 6-1 | Seals Stadium (2-5) | 46-48 | Lost 2 |
| » Starters: Dick Ricketts vs Mike McCormick | Sixth | 7 out |
| Thursday, July 23 |
| » Lost to Giants (54-41), 5-1 | Seals Stadium (2-6) | 46-49 | Lost 3 |
| » Starters: Vinegar Bend Mizell vs Jack Sanford | Sixth | 8 out |
| Friday, July 24 |
| » Defeated Dodgers (54-45), 2-1 | Los Angeles Memorial Coliseum (2-4) | 47-49 | |
| » Starters: Ernie Broglio vs Johnny Podres | Sixth | 8 out |
| Saturday, July 25 |
| » Defeated Dodgers (54-46), 4-2 | Los Angeles Memorial Coliseum (3-4) | 48-49 | Won 2 |
| » Starters: Larry Jackson vs Roger Craig | Sixth | 7 out |
| Sunday, July 26 |
| » Lost to Dodgers (55-46), 8-2 | Los Angeles Memorial Coliseum (3-5) | 48-50 | |
| » Starters: Dick Ricketts vs Don Drysdale | Sixth | 7 out |
| Monday, July 27 |
| » Lost to Reds (44-54), 8-3 | Crosley Field (3-2) | 48-51 | Lost 2 |
| » Starters: Vinegar Bend Mizell vs Bob Purkey | Sixth | 7½ out |
| Future Cardinal Joe DeSa is born in Honolulu, HI. |
| Tuesday, July 28 |
| » Lost to Reds (45-54), 6-4 | Crosley Field (3-3) | 48-52 | Lost 3 |
| » Starters: Ernie Broglio vs Jay Hook | Sixth | 7½ out |
| Wednesday, July 29 |
| » Lost to Reds (46-54), 9-2 | Crosley Field (3-4) | 48-53 | Lost 4 |
| » Starters: Larry Jackson vs Joe Nuxhall | Sixth | 8 out |
| Future Cardinal Dave LaPoint is born in Glens Falls, NY. |
| Thursday, July 30 |
| » Defeated Reds (46-55), 1-0 | Crosley Field (4-4) | 49-53 | |
| » Starters: Bob Gibson vs Jim O'Toole | Sixth | 7½ out |
| Future Cardinal Rick Horton is born in Poughkeepsie, NY. |
| Friday, July 31 |
| » Lost to Braves (55-44), 6-0 | County Stadium (1-5) | 49-54 | |
| » Starters: Dean Stone vs Bob Buhl | Sixth | 8½ out |
| Saturday, August 1 |
| » Lost to Braves (56-44), 8-1 | County Stadium (1-6) | 49-55 | Lost 2 |
| » Starters: Ernie Broglio vs Juan Pizarro | Sixth | 9½ out |
| Sunday, August 2 |
| » Defeated Braves (56-45), 4-3 | County Stadium (2-6) | 50-55 | |
| » Starters: Larry Jackson vs Joey Jay | Fifth | 10 out |
| » Lost to Braves (57-45), 11-5 | County Stadium (2-7) | 50-56 | |
| » Starters: Vinegar Bend Mizell vs Lew Burdette | Fifth | 10 out |
| Tuesday, August 4 |
| » Lost to Pirates (51-56), 7-3 | Sportsman's Park III (26-22) | 50-57 | Lost 2 |
| » Starters: Vern Law vs Bob Gibson | Seventh | 10 out |
| Wednesday, August 5 |
| » Defeated Pirates (51-57), 3-0 | Sportsman's Park III (27-22) | 51-57 | |
| » Starters: Bob Friend vs Ernie Broglio | Sixth | 10 out |
| Thursday, August 6 |
| » Lost to Pirates (52-57), 18-2 | Sportsman's Park III (27-23) | 51-58 | |
| » Starters: Harvey Haddix vs Larry Jackson | Seventh | 11 out |
| Friday, August 7 |
| » Defeated Phillies (44-62), 3-1 | Sportsman's Park III (28-23) | 52-58 | |
| » Starters: Don Cardwell vs Vinegar Bend Mizell | Fifth | 11 out |
| Saturday, August 8 |
| » Defeated Phillies (44-63), 4-3 | Sportsman's Park III (29-23) | 53-58 | Won 2 |
| » Starters: Robin Roberts vs Bob Miller | Fourth | 9½ out |
| » Defeated Phillies (44-64), 5-4 | Sportsman's Park III (30-23) | 54-58 | Won 3 |
| » Starters: Taylor Phillips vs Bob Gibson | Fourth | 9½ out |
| Sunday, August 9 |
| » Lost to Phillies (45-64), 8-3 | Sportsman's Park III (30-24) | 54-59 | |
| » Starters: Gene Conley vs Ernie Broglio | Sixth | 11 out |
| » Lost to Phillies (46-64), 4-2 | Sportsman's Park III (30-25) | 54-60 | Lost 2 |
| » Starters: Jim Owens vs Marshall Bridges | Sixth | 11 out |
| Future Cardinal Jim Adduci is born in Chicago, IL. |
| Monday, August 10 |
| » Lost to Giants (64-47), 3-2 | Sportsman's Park III (30-26) | 54-61 | Lost 3 |
| » Starters: Sam Jones vs Larry Jackson | Sixth | 12 out |
| Tuesday, August 11 |
| » Lost to Giants (65-47), 5-4 | Sportsman's Park III (30-27) | 54-62 | Lost 4 |
| » Starters: Johnny Antonelli vs Vinegar Bend Mizell | Seventh | 13 out |
| » Major-league debuts: Bob Duliba (Cardinals) |
| Wednesday, August 12 |
| Former Cardinal Mike O'Neill dies in Scranton, PA at the age of 82. |
| Thursday, August 13 |
| » Lost to Dodgers (63-51), 7-6 | Sportsman's Park III (30-28) | 54-63 | Lost 5 |
| » Starters: Sandy Koufax vs Bob Miller | Seventh | 13 out |
| Friday, August 14 |
| » Defeated Dodgers (63-52), 2-1 | Sportsman's Park III (31-28) | 55-63 | |
| » Starters: Don Drysdale vs Bob Gibson | Seventh | 12 out |
| Saturday, August 15 |
| » Lost to Dodgers (64-52), 4-3 | Sportsman's Park III (31-29) | 55-64 | |
| » Starters: Johnny Podres vs Ernie Broglio | Seventh | 13 out |
| Sunday, August 16 |
| » Defeated Dodgers (64-53), 5-3 | Sportsman's Park III (32-29) | 56-64 | |
| » Starters: Roger Craig vs Larry Jackson | Seventh | 12 out |
| Monday, August 17 |
| » Defeated Phillies (49-69), 5-4 | Shibe Park (6-4) | 57-64 | Won 2 |
| » Starters: Vinegar Bend Mizell vs Ray Semproch | Seventh | 12 out |
| Tuesday, August 18 |
| » Lost to Phillies (50-69), 2-1 | Shibe Park (6-5) | 57-65 | |
| » Starters: Bob Miller vs Jim Owens | Seventh | 12 out |
| Wednesday, August 19 |
| » Lost to Pirates (60-60), 4-2 | Forbes Field (3-7) | 57-66 | Lost 2 |
| » Starters: Bob Gibson vs Vern Law | Seventh | 12 out |
| Thursday, August 20 |
| » Lost to Pirates (61-60), 3-1 | Forbes Field (3-8) | 57-67 | Lost 3 |
| » Starters: Ernie Broglio vs Bob Friend | Seventh | 13 out |
| Friday, August 21 |
| » Lost to Reds (59-64), 2-1 | Crosley Field (4-5) | 57-68 | Lost 4 |
| » Starters: Larry Jackson vs Jay Hook | Seventh | 14½ out |
| Saturday, August 22 |
| » Lost to Reds (60-64), 11-4 | Crosley Field (4-6) | 57-69 | Lost 5 |
| » Starters: Vinegar Bend Mizell vs Jim O'Toole | Seventh | 15½ out |
| Sunday, August 23 |
| » Lost to Reds (61-64), 5-3 | Crosley Field (4-7) | 57-70 | Lost 6 |
| » Starters: Bob Miller vs Don Newcombe | Seventh | 16 out |
| Tuesday, August 25 |
| » Lost to Braves (68-57), 3-1 | Sportsman's Park III (32-30) | 57-71 | Lost 7 |
| » Starters: Warren Spahn vs Bob Gibson | Seventh | 16½ out |
| Wednesday, August 26 |
| » Defeated Braves (68-58), 5-2 | Sportsman's Park III (33-30) | 58-71 | |
| » Starters: Carl Willey vs Larry Jackson | Seventh | 15½ out |
| Thursday, August 27 |
| » Defeated Braves (68-59), 5-4 | Sportsman's Park III (34-30) | 59-71 | Won 2 |
| » Starters: Bob Buhl vs Vinegar Bend Mizell | Seventh | 14 out |
| Friday, August 28 |
| » Defeated Reds (62-67), 3-2 | Sportsman's Park III (35-30) | 60-71 | Won 3 |
| » Starters: Don Newcombe vs Ernie Broglio | Seventh | 14 out |
| Saturday, August 29 |
| » Defeated Reds (62-68), 7-3 | Sportsman's Park III (36-30) | 61-71 | Won 4 |
| » Starters: Bob Purkey vs Bob Miller | Sixth | 13½ out |
| Sunday, August 30 |
| » Lost to Reds (63-68), 6-4 | Sportsman's Park III (36-31) | 61-72 | |
| » Starters: Jay Hook vs Bob Gibson | Seventh | 13½ out |
| Tuesday, September 1 |
| » Defeated Dodgers (72-60), 3-0 | Los Angeles Memorial Coliseum (4-5) | 62-72 | |
| » Starters: Larry Jackson vs Johnny Podres | Seventh | 12½ out |
| Wednesday, September 2 |
| » Lost to Dodgers (73-60), 9-6 | Los Angeles Memorial Coliseum (4-6) | 62-73 | |
| » Starters: Ernie Broglio vs Danny McDevitt | Seventh | 13½ out |
| Thursday, September 3 |
| » Defeated Dodgers (73-61), 5-3 | Los Angeles Memorial Coliseum (5-6) | 63-73 | |
| » Starters: Bob Miller vs Don Drysdale | Seventh | 13½ out |
| Saturday, September 5 |
| » Lost to Giants (76-59), 3-2 | Seals Stadium (2-7) | 63-74 | |
| » Starters: Vinegar Bend Mizell vs Johnny Antonelli | Seventh | 14 out |
| Sunday, September 6 |
| » Defeated Giants (76-60), 1-0 | Seals Stadium (3-7) | 64-74 | |
| » Starters: Larry Jackson vs Mike McCormick | Seventh | 13 out |
| Monday, September 7 |
| » Lost to Giants (77-60), 4-2 | Seals Stadium (3-8) | 64-75 | |
| » Starters: Bob Gibson vs Sam Jones | Sixth | 14 out |
| Wednesday, September 9 |
| » Lost to Braves (75-63), 5-3 | County Stadium (2-8) | 64-76 | Lost 2 |
| » Starters: Ernie Broglio vs Warren Spahn | Sixth | 15 out |
| Thursday, September 10 |
| » Lost to Braves (76-63), 7-4 | County Stadium (2-9) | 64-77 | Lost 3 |
| » Starters: Larry Jackson vs Juan Pizarro | Sixth | 15 out |
| » Major-league debuts: Duke Carmel and Tim McCarver (Cardinals) |
| Friday, September 11 |
| » Lost to Cubs (67-73), 2-1 | Wrigley Field (5-4) | 64-78 | Lost 4 |
| » Starters: Bob Miller vs Bob Anderson | Seventh | 15 out |
| Saturday, September 12 |
| » Defeated Cubs (67-74), 6-4 | Wrigley Field (6-4) | 65-78 | |
| » Starters: Bob Gibson vs Art Ceccarelli | Sixth | 15 out |
| Sunday, September 13 |
| » Lost to Cubs (68-74), 8-0 | Wrigley Field (6-5) | 65-79 | |
| » Starters: Tom Hughes vs Glen Hobbie | Sixth | 16 out |
| » Major-league debuts: Tom Hughes (Cardinals) |
| Tuesday, September 15 |
| » Defeated Phillies (60-85), 6-4 | Sportsman's Park III (37-31) | 66-79 | |
| » Starters: Ed Keegan vs Ernie Broglio | Sixth | 15½ out |
| Wednesday, September 16 |
| » Major-league debuts: Al Spangler (Braves) |
| Thursday, September 17 |
| » Lost to Pirates (75-72), 7-0 | Sportsman's Park III (37-32) | 66-80 | |
| » Starters: Harvey Haddix vs Larry Jackson | Sixth | 16 out |
| Saturday, September 19 |
| » Defeated Cubs (70-77), 2-1 | Sportsman's Park III (38-32) | 67-80 | |
| » Starters: Bob Anderson vs Bob Miller | Sixth | 14½ out |
| Sunday, September 20 |
| » Defeated Cubs (70-78), 11-4 | Sportsman's Park III (39-32) | 68-80 | Won 2 |
| » Starters: Moe Drabowsky vs Bob Blaylock | Seventh | 14½ out |
| Monday, September 21 |
|