| Saturday, February 14 |
| Future Athletic Alejandro Sanchez is born in San Pedro de Macoris, D.R. |
| Monday, March 9 |
| Future Athletic Shooty Babitt is born in Oakland, CA. |
| Sunday, March 15 |
| Future Athletic Harold Baines is born in Easton, MD. |
| Friday, April 10 |
| » Lost to Indians (1-0), 6-4 | Municipal Stadium (0-1) | 0-1 | |
| » Starters: Gary Bell vs Bob Grim | Third | 1 out |
| Saturday, April 11 |
| » Lost to Indians (2-0), 3-2 | Municipal Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Don Ferrarese vs Ned Garver | Fifth | 2 out |
| Tuesday, April 14 |
| » Lost to White Sox (4-0), 2-0 | Comiskey Park I (0-1) | 0-3 | Lost 3 |
| » Starters: Ralph Terry vs Billy Pierce | Sixth | 3½ out |
| Wednesday, April 15 |
| » Defeated White Sox (4-1), 10-8 | Comiskey Park I (1-1) | 1-3 | |
| » Starters: Bob Grim vs Barry Latman | Sixth | 3 out |
| » Major-league debuts: Claude Raymond (White Sox) |
| Thursday, April 16 |
| » Defeated White Sox (4-2), 6-0 | Comiskey Park I (2-1) | 2-3 | Won 2 |
| » Starters: Ned Garver vs Early Wynn | Fifth | 2½ out |
| Friday, April 17 |
| » Lost to Indians (5-0), 4-3 | Cleveland Stadium (0-1) | 2-4 | |
| » Starters: Rip Coleman vs Gary Bell | Fifth | 3½ out |
| » Major-league debuts: Ray Webster (Indians) |
| Saturday, April 18 |
| » Lost to Indians (6-0), 13-4 | Cleveland Stadium (0-2) | 2-5 | Lost 2 |
| » Starters: Ralph Terry vs Don Ferrarese | Sixth | 4½ out |
| Sunday, April 19 |
| » Defeated Indians (6-1), 4-3 | Cleveland Stadium (1-2) | 3-5 | |
| » Starters: Ray Herbert vs Herb Score | Fifth | 3½ out |
| Tuesday, April 21 |
| » Defeated White Sox (5-4), 8-3 | Municipal Stadium (1-2) | 4-5 | Won 2 |
| » Starters: Billy Pierce vs Bob Grim | Fifth | 3½ out |
| Wednesday, April 22 |
| » Lost to White Sox (6-4), 20-6 | Municipal Stadium (1-3) | 4-6 | |
| » Starters: Early Wynn vs Ned Garver | Sixth | 4½ out |
| Thursday, April 23 |
| » Major-league debuts: Jim Perry (Indians) |
| Friday, April 24 |
| » Defeated Tigers (1-10), 10-1 | Municipal Stadium (2-3) | 5-6 | |
| » Starters: Billy Hoeft vs Ralph Terry | Fourth | 5 out |
| Saturday, April 25 |
| » Defeated Tigers (1-11), 8-7 | Municipal Stadium (3-3) | 6-6 | Won 2 |
| » Starters: Paul Foytack vs Ned Garver | Fourth | 4 out |
| Sunday, April 26 |
| » Defeated Tigers (1-12), 4-3 | Municipal Stadium (4-3) | 7-6 | Won 3 |
| » Starters: Jim Bunning vs Bob Grim | Third | 2½ out |
| Tuesday, April 28 |
| » Lost to Senators (7-8), 8-3 | Municipal Stadium (4-4) | 7-7 | |
| » Starters: Russ Kemmerer vs Ray Herbert | Third | 3 out |
| Wednesday, April 29 |
| » Defeated Senators (7-9), 7-6 | Municipal Stadium (5-4) | 8-7 | |
| » Starters: Pedro Ramos vs Ralph Terry | Third | 2½ out |
| Thursday, April 30 |
| » Defeated Orioles (9-7), 4-3 | Municipal Stadium (6-4) | 9-7 | Won 2 |
| » Starters: Jack Harshman vs Ned Garver | Third | 2 out |
| Friday, May 1 |
| » Defeated Orioles (9-8), 6-3 | Municipal Stadium (7-4) | 10-7 | Won 3 |
| » Starters: Jerry Walker vs Bob Grim | Third | 2 out |
| Saturday, May 2 |
| » Lost to Orioles (10-8), 3-1 | Municipal Stadium (7-5) | 10-8 | |
| » Starters: Hoyt Wilhelm vs Ray Herbert | Third | 3 out |
| Sunday, May 3 |
| » Defeated Red Sox (7-9), 7-3 | Municipal Stadium (8-5) | 11-8 | |
| » Starters: Frank Sullivan vs Ralph Terry | Second | 2½ out |
| Monday, May 4 |
| » Lost to Red Sox (8-9), 8-4 | Municipal Stadium (8-6) | 11-9 | |
| » Starters: Frank Baumann vs John Tsitouris | Third | 3 out |
| Tuesday, May 5 |
| » Lost to Yankees (8-12), 3-2 | Municipal Stadium (8-7) | 11-10 | Lost 2 |
| » Starters: Whitey Ford vs Ned Garver | Fourth | 4 out |
| Wednesday, May 6 |
| » Lost to Yankees (9-12), 7-4 | Municipal Stadium (8-8) | 11-11 | Lost 3 |
| » Starters: Art Ditmar vs Bob Grim | Fifth | 4 out |
| Friday, May 8 |
| » Lost to Tigers (7-16), 5-4 | Tiger Stadium (0-1) | 11-12 | Lost 4 |
| » Starters: Ray Herbert vs Don Mossi | Fifth | 5 out |
| Saturday, May 9 |
| » Lost to Tigers (8-16), 7-4 | Tiger Stadium (0-2) | 11-13 | Lost 5 |
| » Starters: Bob Grim vs Jim Bunning | Fifth | 5 out |
| Sunday, May 10 |
| » Lost to Tigers (9-16), 7-6 | Tiger Stadium (0-3) | 11-14 | Lost 6 |
| » Starters: Ralph Terry vs Paul Foytack | Seventh | 4½ out |
| Thursday, May 14 |
| » Defeated Orioles (15-13), 2-1 | Memorial Stadium (1-0) | 12-14 | |
| » Starters: Ned Garver vs Billy O'Dell | Fifth | 4½ out |
| Friday, May 15 |
| » Defeated Senators (15-16), 4-2 | Griffith Stadium (1-0) | 13-14 | Won 2 |
| » Starters: Ray Herbert vs Russ Kemmerer | Fifth | 4½ out |
| Saturday, May 16 |
| » Lost to Senators (16-16), 7-2 | Griffith Stadium (1-1) | 13-15 | |
| » Starters: Ralph Terry vs Camilo Pascual | Fifth | 5½ out |
| Sunday, May 17 |
| » Lost to Yankees (12-16), 3-2 | Yankee Stadium (0-1) | 13-16 | Lost 2 |
| » Starters: Bud Daley vs Don Larsen | Fifth | 5½ out |
| » Defeated Yankees (12-17), 10-0 | Yankee Stadium (1-1) | 14-16 | |
| » Starters: Bob Grim vs Tom Sturdivant | Fifth | 5½ out |
| Wednesday, May 20 |
| » Defeated Red Sox (13-19), 8-2 | Fenway Park (1-0) | 15-16 | Won 2 |
| » Starters: Ray Herbert vs Billy Hoeft | Fourth | 5½ out |
| Thursday, May 21 |
| » Lost to Red Sox (14-19), 5-0 | Fenway Park (1-1) | 15-17 | |
| » Starters: Ned Garver vs Tom Brewer | Fourth | 6 out |
| Friday, May 22 |
| » Lost to White Sox (23-13), 2-1 | Municipal Stadium (8-9) | 15-18 | Lost 2 |
| » Starters: Bob Shaw vs Bob Grim | Fourth | 7 out |
| Saturday, May 23 |
| » Defeated White Sox (23-14), 16-0 | Municipal Stadium (9-9) | 16-18 | |
| » Starters: Early Wynn vs Bud Daley | Fourth | 6 out |
| Sunday, May 24 |
| » Defeated White Sox (23-15), 8-6 | Municipal Stadium (10-9) | 17-18 | Won 2 |
| » Starters: Billy Pierce vs Ray Herbert | Fourth | 5½ out |
| Monday, May 25 |
| » Lost to Tigers (16-22), 4-3 | Municipal Stadium (10-10) | 17-19 | |
| » Starters: Jerry Davie vs Rip Coleman | Fifth | 6 out |
| Tuesday, May 26 |
| » Lost to Tigers (17-22), 9-5 | Municipal Stadium (10-11) | 17-20 | Lost 2 |
| » Starters: Paul Foytack vs Ned Garver | Fifth | 7 out |
| Thursday, May 28 |
| » Defeated Indians (24-15), 7-2 | Cleveland Stadium (2-2) | 18-20 | |
| » Starters: Bud Daley vs Mudcat Grant | Fourth | 5½ out |
| Saturday, May 30 |
| » Lost to Indians (25-15), 3-2 | Cleveland Stadium (2-3) | 18-21 | |
| » Starters: Johnny Kucks vs Herb Score | Fourth | 5½ out |
| » Defeated Indians (25-16), 3-1 | Cleveland Stadium (3-3) | 19-21 | |
| » Starters: Rip Coleman vs Cal McLish | Fourth | 5½ out |
| Sunday, May 31 |
| » Defeated White Sox (25-19), 9-1 | Comiskey Park I (3-1) | 20-21 | Won 2 |
| » Starters: Ned Garver vs Early Wynn | Fourth | 4½ out |
| Monday, June 1 |
| » Defeated White Sox (25-20), 3-1 | Comiskey Park I (4-1) | 21-21 | Won 3 |
| » Starters: Bud Daley vs Ray Moore | Fourth | 3½ out |
| Tuesday, June 2 |
| » Defeated Red Sox (19-25), 5-3 | Municipal Stadium (11-11) | 22-21 | Won 4 |
| » Starters: Frank Sullivan vs Ray Herbert | Fourth | 2½ out |
| Wednesday, June 3 |
| » Defeated Red Sox (19-26), 5-3 | Municipal Stadium (12-11) | 23-21 | Won 5 |
| » Starters: Bill Monbouquette vs Johnny Kucks | Fourth | 1½ out |
| Thursday, June 4 |
| » Lost to Red Sox (20-26), 5-2 | Municipal Stadium (12-12) | 23-22 | |
| » Starters: Jerry Casale vs Rip Coleman | Fourth | 2½ out |
| Friday, June 5 |
| » Lost to Orioles (27-23), 6-1 | Municipal Stadium (12-13) | 23-23 | Lost 2 |
| » Starters: Milt Pappas vs Ned Garver | Fourth | 3½ out |
| Saturday, June 6 |
| » Defeated Orioles (27-24), 5-1 | Municipal Stadium (13-13) | 24-23 | |
| » Starters: Hal Brown vs Bud Daley | Fourth | 2½ out |
| Sunday, June 7 |
| » Lost to Orioles (28-24), 3-0 | Municipal Stadium (13-14) | 24-24 | |
| » Starters: Hoyt Wilhelm vs Ray Herbert | Fourth | 3 out |
| Tuesday, June 9 |
| » Lost to Yankees (25-25), 9-8 | Yankee Stadium (1-2) | 24-25 | Lost 2 |
| » Starters: Johnny Kucks vs Whitey Ford | Fifth | 3 out |
| Wednesday, June 10 |
| » Lost to Yankees (26-25), 6-4 | Yankee Stadium (1-3) | 24-26 | Lost 3 |
| » Starters: Bud Daley vs Art Ditmar | Sixth | 4 out |
| Thursday, June 11 |
| » Defeated Yankees (26-26), 9-5 | Yankee Stadium (2-3) | 25-26 | |
| » Starters: Ned Garver vs Bob Turley | Sixth | 4 out |
| Future Athletic Mike Davis is born in San Diego, CA. |
| Friday, June 12 |
| » Defeated Red Sox (23-32), 3-2 | Fenway Park (2-1) | 26-26 | Won 2 |
| » Starters: Rip Coleman vs Frank Sullivan | Fourth | 3½ out |
| Saturday, June 13 |
| » Lost to Red Sox (24-32), 6-1 | Fenway Park (2-2) | 26-27 | |
| » Starters: Ray Herbert vs Tom Brewer | Sixth | 3½ out |
| Sunday, June 14 |
| » Lost to Red Sox (25-32), 6-1 | Fenway Park (2-3) | 26-28 | Lost 2 |
| » Starters: Johnny Kucks vs Jerry Casale | Sixth | 5 out |
| Monday, June 15 |
| » Lost to Senators (25-34), 8-5 | Griffith Stadium (1-2) | 26-29 | Lost 3 |
| » Starters: Bud Daley vs John Romonosky | Sixth | 5½ out |
| Wednesday, June 17 |
| » Lost to Senators (26-34), 7-2 | Griffith Stadium (1-3) | 26-30 | Lost 4 |
| » Starters: Ned Garver vs Camilo Pascual | Sixth | 6½ out |
| Thursday, June 18 |
| » Lost to Senators (27-34), 7-5 | Griffith Stadium (1-4) | 26-31 | Lost 5 |
| » Starters: Ray Herbert vs Bill Fischer | Fifth | 6½ out |
| Friday, June 19 |
| » Lost to Orioles (33-29), 8-2 | Memorial Stadium (1-1) | 26-32 | Lost 6 |
| » Starters: Johnny Kucks vs Billy O'Dell | Sixth | 7 out |
| » Lost to Orioles (34-29), 2-0 | Memorial Stadium (1-2) | 26-33 | Lost 7 |
| » Starters: Rip Coleman vs Hal Brown | Sixth | 7 out |
| Saturday, June 20 |
| » Defeated Orioles (34-30), 6-2 | Memorial Stadium (2-2) | 27-33 | |
| » Starters: Bud Daley vs Hoyt Wilhelm | Seventh | 6 out |
| Sunday, June 21 |
| » Defeated Orioles (34-31), 7-0 | Memorial Stadium (3-2) | 28-33 | Won 2 |
| » Starters: Ned Garver vs Arnie Portocarrero | Fifth | 6½ out |
| Monday, June 22 |
| » Lost to Yankees (33-31), 11-6 | Municipal Stadium (13-15) | 28-34 | |
| » Starters: Bob Turley vs Ray Herbert | Fifth | 7 out |
| Tuesday, June 23 |
| » Lost to Yankees (34-31), 10-2 | Municipal Stadium (13-16) | 28-35 | Lost 2 |
| » Starters: Whitey Ford vs Rip Coleman | Seventh | 7 out |
| Wednesday, June 24 |
| » Defeated Yankees (34-32), 4-3 | Municipal Stadium (14-16) | 29-35 | |
| » Starters: Jim Bronstad vs Bud Daley | Seventh | 6 out |
| Thursday, June 25 |
| » Lost to Yankees (35-32), 5-4 | Municipal Stadium (14-17) | 29-36 | |
| » Starters: Duke Maas vs Tom Sturdivant | Seventh | 7 out |
| Friday, June 26 |
| » Lost to Senators (31-38), 8-4 | Municipal Stadium (14-18) | 29-37 | Lost 2 |
| » Starters: Camilo Pascual vs Ned Garver | Seventh | 8 out |
| Saturday, June 27 |
| » Defeated Senators (31-39), 5-4 | Municipal Stadium (15-18) | 30-37 | |
| » Starters: Bill Fischer vs Ray Herbert | Seventh | 7 out |
| Sunday, June 28 |
| » Lost to Senators (32-39), 7-3 | Municipal Stadium (15-19) | 30-38 | |
| » Starters: Russ Kemmerer vs Howie Reed | Eighth | 8½ out |
| Monday, June 29 |
| » Defeated Tigers (37-36), 10-3 | Tiger Stadium (1-3) | 31-38 | |
| » Starters: Bud Daley vs Jim Bunning | Seventh | 8 out |
| Tuesday, June 30 |
| » Lost to Tigers (38-36), 4-0 | Tiger Stadium (1-4) | 31-39 | |
| » Starters: Rip Coleman vs Frank Lary | Seventh | 9 out |
| Wednesday, July 1 |
| » Lost to Tigers (39-36), 5-4 | Tiger Stadium (1-5) | 31-40 | Lost 2 |
| » Starters: Ned Garver vs Paul Foytack | Seventh | 9 out |
| Thursday, July 2 |
| » Defeated Indians (40-32), 6-4 | Municipal Stadium (16-19) | 32-40 | |
| » Starters: Gary Bell vs Ray Herbert | Seventh | 8 out |
| Friday, July 3 |
| » Lost to Indians (41-32), 8-4 | Municipal Stadium (16-20) | 32-41 | |
| » Starters: Herb Score vs Howie Reed | Seventh | 9 out |
| Saturday, July 4 |
| » Lost to White Sox (42-34), 7-4 | Municipal Stadium (16-21) | 32-42 | Lost 2 |
| » Starters: Dick Donovan vs Bud Daley | Seventh | 10 out |
| » Defeated White Sox (42-35), 8-3 | Municipal Stadium (17-21) | 33-42 | |
| » Starters: Billy Pierce vs Rip Coleman | Seventh | 10 out |
| Sunday, July 5 |
| » Lost to White Sox (43-35), 4-3 | Municipal Stadium (17-22) | 33-43 | |
| » Starters: Barry Latman vs Ned Garver | Seventh | 11 out |
| Thursday, July 9 |
| » Defeated Tigers (40-41), 5-0 | Municipal Stadium (18-22) | 34-43 | |
| » Starters: Frank Lary vs Ray Herbert | Seventh | 9½ out |
| » Defeated Tigers (40-42), 4-0 | Municipal Stadium (19-22) | 35-43 | Won 2 |
| » Starters: Ray Narleski vs Johnny Kucks | Seventh | 9½ out |
| Friday, July 10 |
| » Lost to Tigers (41-42), 5-2 | Municipal Stadium (19-23) | 35-44 | |
| » Starters: Jim Bunning vs Howie Reed | Seventh | 10½ out |
| Saturday, July 11 |
| » Lost to White Sox (45-36), 8-3 | Comiskey Park I (4-2) | 35-45 | Lost 2 |
| » Starters: Ned Garver vs Barry Latman | Eighth | 11½ out |
| Sunday, July 12 |
| » Lost to White Sox (46-36), 5-3 | Comiskey Park I (4-3) | 35-46 | Lost 3 |
| » Starters: Bud Daley vs Dick Donovan | Eighth | 12½ out |
| » Lost to White Sox (47-36), 9-7 | Comiskey Park I (4-4) | 35-47 | Lost 4 |
| » Starters: Rip Coleman vs Bob Shaw | Eighth | 12½ out |
| Tuesday, July 14 |
| » Defeated Orioles (44-41), 1-0 | Memorial Stadium (4-2) | 36-47 | |
| » Starters: Ray Herbert vs Billy O'Dell | Eighth | 12 out |
| » Lost to Orioles (45-41), 3-1 | Memorial Stadium (4-3) | 36-48 | |
| » Starters: Johnny Kucks vs Milt Pappas | Eighth | 12 out |
| Thursday, July 16 |
| » Defeated Orioles (45-42), 4-3 | Memorial Stadium (5-3) | 37-48 | |
| » Starters: Bud Daley vs Jerry Walker | Eighth | 11½ out |
| Friday, July 17 |
| » Defeated Senators (42-45), 7-4 | Griffith Stadium (2-4) | 38-48 | Won 2 |
| » Starters: Ned Garver vs Russ Kemmerer | Eighth | 11½ out |
| Saturday, July 18 |
| » Defeated Senators (42-46), 10-3 | Griffith Stadium (3-4) | 39-48 | Won 3 |
| » Starters: Ray Herbert vs Pedro Ramos | Seventh | 11½ out |
| Sunday, July 19 |
| » Lost to Senators (43-46), 7-0 | Griffith Stadium (3-5) | 39-49 | |
| » Starters: Johnny Kucks vs Camilo Pascual | Seventh | 10½ out |
| » Defeated Senators (43-47), 6-5 | Griffith Stadium (4-5) | 40-49 | |
| » Starters: Tom Sturdivant vs Hal Griggs | Seventh | 10½ out |
| Tuesday, July 21 |
| » Defeated Orioles (48-44), 8-1 | Municipal Stadium (20-23) | 41-49 | Won 2 |
| » Starters: Milt Pappas vs Bud Daley | Seventh | 10½ out |
| Wednesday, July 22 |
| » Defeated Orioles (48-45), 6-3 | Municipal Stadium (21-23) | 42-49 | Won 3 |
| » Starters: Jerry Walker vs Ray Herbert | Seventh | 10½ out |
| Thursday, July 23 |
| » Defeated Orioles (48-46), 9-3 | Municipal Stadium (22-23) | 43-49 | Won 4 |
| » Starters: Hal Brown vs Ned Garver | Sixth | 10 out |
| Friday, July 24 |
| » Defeated Red Sox (40-53), 3-1 | Municipal Stadium (23-23) | 44-49 | Won 5 |
| » Starters: Frank Sullivan vs Johnny Kucks | Sixth | 10 out |
| Saturday, July 25 |
| » Defeated Red Sox (40-54), 3-0 | Municipal Stadium (24-23) | 45-49 | Won 6 |
| » Starters: Al Schroll vs Bud Daley | Fifth | 10 out |
| Sunday, July 26 |
| » Defeated Red Sox (40-55), 5-4 | Municipal Stadium (25-23) | 46-49 | Won 7 |
| » Starters: Tom Brewer vs Ray Herbert | Sixth | 10 out |
| Monday, July 27 |
| » Defeated Senators (43-55), 7-6 | Municipal Stadium (26-23) | 47-49 | Won 8 |
| » Starters: John Romonosky vs Ned Garver | Fourth | 9 out |
| Tuesday, July 28 |
| » Defeated Senators (43-56), 6-1 | Municipal Stadium (27-23) | 48-49 | Won 9 |
| » Starters: Camilo Pascual vs Johnny Kucks | Fourth | 9 out |
| Wednesday, July 29 |
| » Defeated Senators (43-57), 5-4 | Municipal Stadium (28-23) | 49-49 | Won 10 |
| » Starters: Bill Fischer vs John Tsitouris | Fourth | 8½ out |
| Thursday, July 30 |
| » Defeated Senators (43-58), 4-1 | Municipal Stadium (29-23) | 50-49 | Won 11 |
| » Starters: Hal Griggs vs Bud Daley | Third | 8½ out |
| Friday, July 31 |
| » Lost to Yankees (49-51), 11-2 | Municipal Stadium (29-24) | 50-50 | |
| » Starters: Don Larsen vs Ned Garver | Third | 9½ out |
| Saturday, August 1 |
| » Defeated Yankees (49-52), 2-1 | Municipal Stadium (30-24) | 51-50 | |
| » Starters: Art Ditmar vs Johnny Kucks | Third | 9½ out |
| Sunday, August 2 |
| » Lost to Yankees (50-52), 7-5 | Municipal Stadium (30-25) | 51-51 | |
| » Starters: Ralph Terry vs Bud Daley | Third | 11 out |
| Tuesday, August 4 |
| » Lost to Red Sox (46-58), 4-1 | Fenway Park (2-4) | 51-52 | Lost 2 |
| » Starters: John Tsitouris vs Tom Brewer | Fourth | 10½ out |
| » Defeated Red Sox (46-59), 8-6 | Fenway Park (3-4) | 52-52 | |
| » Starters: Rip Coleman vs Al Schroll | Fourth | 10½ out |
| Wednesday, August 5 |
| » Lost to Red Sox (47-59), 17-6 | Fenway Park (3-5) | 52-53 | |
| » Starters: Johnny Kucks vs Earl Wilson | Fourth | 11 out |
| Thursday, August 6 |
| » Lost to Red Sox (48-59), 4-3 | Fenway Park (3-6) | 52-54 | Lost 2 |
| » Starters: Ray Herbert vs Jerry Casale | Fourth | 11½ out |
| Friday, August 7 |
| » Lost to Yankees (52-54), 3-0 | Yankee Stadium (2-4) | 52-55 | Lost 3 |
| » Starters: Bud Daley vs Whitey Ford | Fifth | 12½ out |
| Saturday, August 8 |
| » Lost to Yankees (53-54), 3-0 | Yankee Stadium (2-5) | 52-56 | Lost 4 |
| » Starters: Johnny Kucks vs Bob Turley | Fifth | 13 out |
| Sunday, August 9 |
| » Lost to Yankees (54-54), 4-3 | Yankee Stadium (2-6) | 52-57 | Lost 5 |
| » Starters: John Tsitouris vs Ralph Terry | Sixth | 15 out |
| » Lost to Yankees (55-54), 3-2 | Yankee Stadium (2-7) | 52-58 | Lost 6 |
| » Starters: Ned Garver vs Eli Grba | Sixth | 15 out |
| Monday, August 10 |
| » Lost to Indians (65-46), 6-4 | Municipal Stadium (30-26) | 52-59 | Lost 7 |
| » Starters: Cal McLish vs Ray Herbert | Sixth | 15½ out |
| Tuesday, August 11 |
| » Defeated Indians (65-47), 7-3 | Municipal Stadium (31-26) | 53-59 | |
| » Starters: Mudcat Grant vs Bud Daley | Sixth | 14½ out |
| Wednesday, August 12 |
| » Lost to Indians (66-47), 9-4 | Municipal Stadium (31-27) | 53-60 | |
| » Starters: Gary Bell vs Johnny Kucks | Sixth | 15½ out |
| Thursday, August 13 |
| » Lost to Indians (67-47), 7-5 | Municipal Stadium (31-28) | 53-61 | Lost 2 |
| » Starters: Jack Harshman vs John Tsitouris | Sixth | 16½ out |
| Friday, August 14 |
| » Lost to White Sox (69-43), 5-1 | Municipal Stadium (31-29) | 53-62 | Lost 3 |
| » Starters: Bob Shaw vs Johnny Kucks | Sixth | 17½ out |
| Saturday, August 15 |
| » Defeated White Sox (69-44), 2-1 | Municipal Stadium (32-29) | 54-62 | |
| » Starters: Billy Pierce vs Bud Daley | Sixth | 16½ out |
| Sunday, August 16 |
| » Defeated White Sox (69-45), 7-2 | Municipal Stadium (33-29) | 55-62 | Won 2 |
| » Starters: Dick Donovan vs Ned Garver | Sixth | 15½ out |
| Tuesday, August 18 |
| » Lost to Red Sox (55-63), 5-4 | Municipal Stadium (33-30) | 55-63 | |
| » Starters: Tom Brewer vs Johnny Kucks | Sixth | 16½ out |
| Wednesday, August 19 |
| » Defeated Red Sox (55-64), 6-3 | Municipal Stadium (34-30) | 56-63 | |
| » Starters: Frank Sullivan vs Bud Daley | Sixth | 15½ out |
| Thursday, August 20 |
| » Lost to Red Sox (56-64), 11-10 | Municipal Stadium (34-31) | 56-64 | |
| » Starters: Jerry Casale vs John Tsitouris | Sixth | 15½ out |
| Friday, August 21 |
| » Lost to Yankees (61-60), 9-7 | Municipal Stadium (34-32) | 56-65 | Lost 2 |
| » Starters: Duke Maas vs Ray Herbert | Sixth | 16½ out |
| Saturday, August 22 |
| » Defeated Yankees (61-61), 8-7 | Municipal Stadium (35-32) | 57-65 | |
| » Starters: Jim Coates vs Ned Garver | Sixth | 16½ out |
| Sunday, August 23 |
| » Lost to Senators (50-73), 7-3 | Municipal Stadium (35-33) | 57-66 | |
| » Starters: Camilo Pascual vs Bud Daley | Sixth | 16½ out |
| » Defeated Senators (50-74), 5-2 | Municipal Stadium (36-33) | 58-66 | |
| » Starters: Hal Woodeshick vs Johnny Kucks | Sixth | 16½ out |
| Tuesday, August 25 |
| » Defeated Orioles (60-63), 6-5 | Municipal Stadium (37-33) | 59-66 | Won 2 |
| » Starters: Billy O'Dell vs Ray Herbert | Sixth | 17 out |
| Wednesday, August 26 |
| » Lost to Orioles (61-63), 6-3 | Municipal Stadium (37-34) | 59-67 | |
| » Starters: Jerry Walker vs Bud Daley | Fifth | 17 out |
| Friday, August 28 |
| » Lost to Tigers (63-65), 6-5 | Municipal Stadium (37-35) | 59-68 | Lost 2 |
| » Starters: Frank Lary vs Johnny Kucks | Fifth | 18½ out |
| Saturday, August 29 |
| » Lost to Tigers (64-65), 9-3 | Municipal Stadium (37-36) | 59-69 | Lost 3 |
| » Starters: Paul Foytack vs Ray Herbert | Sixth | 19½ out |
| Sunday, August 30 |
| » Lost to Tigers (65-65), 4-0 | Municipal Stadium (37-37) | 59-70 | Lost 4 |
| » Starters: Don Mossi vs Bud Daley | Seventh | 21 out |
| Wednesday, September 2 |
| » Lost to Indians (76-55), 6-3 | Cleveland Stadium (3-4) | 59-71 | Lost 5 |
| » Starters: Ned Garver vs Herb Score | Seventh | 22 out |
| Friday, September 4 |
| » Lost to Tigers (67-67), 9-2 | Tiger Stadium (1-6) | 59-72 | Lost 6 |
| » Starters: Bud Daley vs Don Mossi | Sixth | 23 out |
| Saturday, September 5 |
| » Lost to Tigers (68-67), 5-4 | Tiger Stadium (1-7) | 59-73 | Lost 7 |
| » Starters: Johnny Kucks vs Jim Bunning | Sixth | 23 out |
| Sunday, September 6 |
| » Lost to Tigers (69-67), 7-6 | Tiger Stadium (1-8) | 59-74 | Lost 8 |
| » Starters: Ray Herbert vs Frank Lary | Seventh | 23 out |
| Monday, September 7 |
| » Lost to White Sox (84-52), 2-1 | Comiskey Park I (4-5) | 59-75 | Lost 9 |
| » Starters: Ned Garver vs Billy Pierce | Seventh | 25 out |
| » Lost to White Sox (85-52), 13-7 | Comiskey Park I (4-6) | 59-76 | Lost 10 |
| » Starters: John Tsitouris vs Barry Latman | Seventh | 25 out |
| » Major-league debuts: Evans Killeen (Athletics) |
| Tuesday, September 8 |
| » Lost to White Sox (86-52), 3-2 | Comiskey Park I (4-7) | 59-77 | Lost 11 |
| » Starters: Bud Daley vs Early Wynn | Seventh | 26 out |
| Wednesday, September 9 |
| » Lost to Yankees (69-69), 4-0 | Yankee Stadium (2-8) | 59-78 | Lost 12 |
| » Starters: Johnny Kucks vs Art Ditmar | Seventh | 27 out |
| Thursday, September 10 |
| » Lost to Yankees (70-69), 12-1 | Yankee Stadium (2-9) | 59-79 | Lost 13 |
| » Starters: Ray Herbert vs Ralph Terry | Seventh | 27 out |
| » Major-league debuts: Ken Hunt and Gordie Windhorn (Yankees) |
| Friday, September 11 |
| » Defeated Red Sox (65-76), 8-6 | Fenway Park (4-6) | 60-79 | |
| » Starters: John Tsitouris vs Tom Brewer | Seventh | 25½ out |
| Saturday, September 12 |
| » Lost to Red Sox (66-76), 4-3 | Fenway Park (4-7) | 60-80 | |
| » Starters: Tom Sturdivant vs Jerry Casale | Seventh | 26½ out |
| Sunday, September 13 |
| » Defeated Orioles (69-73), 9-5 | Memorial Stadium (6-3) | 61-80 | |
| » Starters: Ned Garver vs Arnie Portocarrero | Seventh | 26 out |
| » Defeated Orioles (69-74), 4-1 | Memorial Stadium (7-3) | 62-80 | Won 2 |
| » Starters: Bud Daley vs Milt Pappas | Seventh | 26 out |
| Monday, September 14 |
| » Lost to Orioles (70-74), 9-4 | Memorial Stadium (7-4) | 62-81 | |
| » Starters: Al Grunwald vs Hal Brown | Seventh | 26 out |
| Tuesday, September 15 |
| » Lost to Senators (61-84), 1-0 | Griffith Stadium (4-6) | 62-82 | Lost 2 |
| » Starters: John Tsitouris vs Camilo Pascual | Sixth | 26½ out |
| » Defeated Senators (61-85), 6-2 | Griffith Stadium (5-6) | 63-82 | |
| » Starters: Johnny Kucks vs Pedro Ramos | Sixth | 26½ out |
| Wednesday, September 16 |
| Future Athletic Tim Raines is born in Sanford, FL. |
| Friday, September 18 |
| » Lost to Indians (85-62), 11-2 | Municipal Stadium (37-38) | 63-83 | |
| » Starters: Jim Perry vs Bud Daley | Seventh | 27 out |
| Saturday, September 19 |
| » Lost to Indians (86-62), 13-7 | Municipal Stadium (37-39) | 63-84 | Lost 2 |
| » Starters: Jack Harshman vs Johnny Kucks | Seventh | 27 out |
| » Major-league debuts: Gordy Coleman (Indians) |
| Sunday, September 20 |
| » Lost to Indians (87-62), 4-3 | Municipal Stadium (37-40) | 63-85 | Lost 3 |
| » Starters: Cal McLish vs Ned Garver | Seventh | 27 out |
| Tuesday, September 22 |
| » Lost to Tigers (75-75), 6-4 | Tiger Stadium (1-9) | 63-86 | Lost 4 |
| » Starters: Ken Johnson vs Jim Bunning | Seventh | 28 out |
| Wednesday, September 23 |
| » Defeated Tigers (75-76), 7-6 | Tiger Stadium (2-9) | 64-86 | |
| » Starters: John Tsitouris vs Paul Foytack | Sixth | 27½ out |
| Friday, September 25 |
| » Lost to Indians (88-63), 8-2 | Cleveland Stadium (3-5) | 64-87 | |
| » Starters: Johnny Kucks vs Jake Striker | Seventh | 28 out |
| » Lost to Indians (89-63), 8-7 | Cleveland Stadium (3-6) | 64-88 | Lost 2 |
| » Starters: Bud Daley vs Cal McLish | Seventh | 28 out |
| » Major-league debuts: Jake Striker (Indians) |
| Saturday, September 26 |
| » Defeated Indians (89-64), 8-4 | Cleveland Stadium (4-6) | 65-88 | |
| » Starters: Ken Johnson vs John Briggs | Seventh | 28 out |
| Sunday, September 27 |
| » Defeated Indians (89-65), 6-5 | Cleveland Stadium (5-6) | 66-88 | Won 2 |
| » Starters: Ned Garver vs Herb Score | Seventh | 28 out |
| Monday, September 28 |
| Former Athletic Art Brouthers dies in Charleston, SC at the age of 77. |
| Thursday, October 8 |
| Future Athletic Mike Morgan is born in Tulare, CA. |
| Friday, October 16 |
| Future Athletic Brian Harper is born in Los Angeles, CA. |
| Monday, November 23 |
| Future Athletic Brook Jacoby is born in Philadelphia, PA. |
| Thursday, November 26 |
| Future Athletic Mike Moore is born in Eakly, OK. |
Game information provided by Retrosheet (www.retrosheet.org) |
