| Sunday, March 23 |
| Former Senator Harry Kelley dies in Parkin, AR at the age of 53. |
| Monday, April 14 |
| » Defeated Red Sox (0-1), 5-2 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Frank Sullivan vs Pedro Ramos | First | -- |
| » Major-league debuts: Albie Pearson (Senators) |
| Tuesday, April 15 |
| » Lost to Orioles (1-0), 6-1 | Memorial Stadium (0-1) | 1-1 | |
| » Starters: Camilo Pascual vs Connie Johnson | Second | ½ out |
| » Major-league debuts: Ron Hansen and Jim Marshall (Orioles) |
| Thursday, April 17 |
| » Lost to Orioles (2-0), 4-0 | Memorial Stadium (0-2) | 1-2 | Lost 2 |
| » Starters: Chuck Stobbs vs Milt Pappas | Third | 1½ out |
| Saturday, April 19 |
| » Defeated Red Sox (1-4), 4-3 | Griffith Stadium (2-0) | 2-2 | |
| » Starters: Mike Fornieles vs Pedro Ramos | Third | 1½ out |
| Sunday, April 20 |
| » Defeated Red Sox (1-5), 6-5 | Griffith Stadium (3-0) | 3-2 | Won 2 |
| » Starters: Frank Sullivan vs Camilo Pascual | Second | 1½ out |
| » Major-league debuts: Al Schroll (Red Sox) |
| Tuesday, April 22 |
| » Lost to Orioles (3-3), 4-2 | Griffith Stadium (3-1) | 3-3 | |
| » Starters: Jack Harshman vs Ralph Lumenti | Fourth | 3 out |
| Wednesday, April 23 |
| » Defeated Yankees (7-2), 5-4 | Griffith Stadium (4-1) | 4-3 | |
| » Starters: Johnny Kucks vs Chuck Stobbs | Fourth | 2 out |
| Friday, April 25 |
| » Defeated Red Sox (3-8), 2-0 | Fenway Park (1-0) | 5-3 | Won 2 |
| » Starters: Pedro Ramos vs Frank Baumann | Second | 1 out |
| Saturday, April 26 |
| » Defeated Red Sox (3-9), 7-5 | Fenway Park (2-0) | 6-3 | Won 3 |
| » Starters: Hal Griggs vs Willard Nixon | Second | 1 out |
| Sunday, April 27 |
| » Lost to Red Sox (4-9), 7-5 | Fenway Park (2-1) | 6-4 | |
| » Starters: Russ Kemmerer vs Dave Sisler | Third | 1½ out |
| Wednesday, April 30 |
| » Defeated Indians (7-7), 3-2 | Griffith Stadium (5-1) | 7-4 | |
| » Starters: Herb Score vs Pedro Ramos | Third | 1 out |
| Thursday, May 1 |
| » Lost to Indians (8-7), 9-1 | Griffith Stadium (5-2) | 7-5 | |
| » Starters: Ray Narleski vs Ralph Lumenti | Third | 1½ out |
| Friday, May 2 |
| » Defeated White Sox (4-10), 3-2 | Griffith Stadium (6-2) | 8-5 | |
| » Starters: Dick Donovan vs Camilo Pascual | Second | 1½ out |
| Sunday, May 4 |
| » Defeated Athletics (8-7), 7-3 | Griffith Stadium (7-2) | 9-5 | Won 2 |
| » Starters: Alex Kellner vs Pedro Ramos | Second | 1 out |
| » Tied Athletics, 2-2 | Griffith Stadium (7-2) | 9-5 | |
| » Starters: Jack Urban vs Russ Kemmerer | Second | 1 out |
| Wednesday, May 7 |
| » Lost to Tigers (9-10), 5-1 | Griffith Stadium (7-3) | 9-6 | |
| » Starters: Frank Lary vs Camilo Pascual | Second | 1 out |
| » Defeated Tigers (9-11), 11-4 | Griffith Stadium (8-3) | 10-6 | |
| » Starters: Jim Bunning vs Hal Griggs | Second | 1 out |
| Thursday, May 8 |
| » Defeated Tigers (9-12), 4-1 | Griffith Stadium (9-3) | 11-6 | Won 2 |
| » Starters: Bob Shaw vs Ralph Lumenti | Second | 1½ out |
| Friday, May 9 |
| » Lost to Yankees (11-4), 9-5 | Yankee Stadium (0-1) | 11-7 | |
| » Starters: Pedro Ramos vs Bob Turley | Second | 1½ out |
| Saturday, May 10 |
| » Lost to Yankees (12-4), 8-0 | Yankee Stadium (0-2) | 11-8 | Lost 2 |
| » Starters: Russ Kemmerer vs Whitey Ford | Second | 2½ out |
| Sunday, May 11 |
| » Lost to Yankees (13-4), 4-3 | Yankee Stadium (0-3) | 11-9 | Lost 3 |
| » Starters: Chuck Stobbs vs Bobby Shantz | Second | 2½ out |
| » Defeated Yankees (13-5), 4-0 | Yankee Stadium (1-3) | 12-9 | |
| » Starters: Camilo Pascual vs Johnny Kucks | Second | 2½ out |
| Monday, May 12 |
| » Defeated Red Sox (10-15), 5-4 | Griffith Stadium (10-3) | 13-9 | Won 2 |
| » Starters: Frank Sullivan vs Hal Griggs | Second | 2 out |
| Tuesday, May 13 |
| » Lost to Red Sox (11-15), 9-6 | Griffith Stadium (10-4) | 13-10 | |
| » Starters: Bob Smith vs Pedro Ramos | Second | 3 out |
| Wednesday, May 14 |
| » Lost to Red Sox (12-15), 7-5 | Griffith Stadium (10-5) | 13-11 | Lost 2 |
| » Starters: Dave Sisler vs Ralph Lumenti | Second | 4 out |
| Former Senator Billy Clingman dies in Cincinnati, OH at the age of 89. |
| Friday, May 16 |
| » Lost to Yankees (16-5), 7-2 | Griffith Stadium (10-6) | 13-12 | Lost 3 |
| » Starters: Whitey Ford vs Camilo Pascual | Second | 5 out |
| Saturday, May 17 |
| » Lost to Yankees (17-5), 6-5 | Griffith Stadium (10-7) | 13-13 | Lost 4 |
| » Starters: Bobby Shantz vs Chuck Stobbs | Third | 6 out |
| Sunday, May 18 |
| » Lost to Yankees (18-5), 5-2 | Griffith Stadium (10-8) | 13-14 | Lost 5 |
| » Starters: Sal Maglie vs Pedro Ramos | Sixth | 8 out |
| » Lost to Yankees (19-5), 3-0 | Griffith Stadium (10-9) | 13-15 | Lost 6 |
| » Starters: Bob Turley vs Al Cicotte | Sixth | 8 out |
| Tuesday, May 20 |
| » Lost to Athletics (14-12), 7-3 | Municipal Stadium (0-1) | 13-16 | Lost 7 |
| » Starters: Hal Griggs vs Ned Garver | Sixth | 9 out |
| Wednesday, May 21 |
| » Defeated Athletics (14-13), 6-1 | Municipal Stadium (1-1) | 14-16 | |
| » Starters: Russ Kemmerer vs Ralph Terry | Fifth | 9 out |
| Thursday, May 22 |
| » Lost to Indians (17-17), 3-1 | Cleveland Stadium (0-1) | 14-17 | |
| » Starters: Camilo Pascual vs Mudcat Grant | Fifth | 10 out |
| Friday, May 23 |
| » Lost to Indians (18-17), 2-1 | Cleveland Stadium (0-2) | 14-18 | Lost 2 |
| » Starters: Pedro Ramos vs Cal McLish | Fifth | 11 out |
| Saturday, May 24 |
| » Defeated Indians (18-18), 6-3 | Cleveland Stadium (1-2) | 15-18 | |
| » Starters: Chuck Stobbs vs Don Mossi | Fifth | 10 out |
| Sunday, May 25 |
| » Lost to Tigers (15-21), 7-2 | Tiger Stadium (0-1) | 15-19 | |
| » Starters: Russ Kemmerer vs Jim Bunning | Eighth | 12 out |
| » Lost to Tigers (16-21), 6-3 | Tiger Stadium (0-2) | 15-20 | Lost 2 |
| » Starters: Al Cicotte vs Hank Aguirre | Eighth | 12 out |
| Tuesday, May 27 |
| » Lost to White Sox (16-19), 7-3 | Comiskey Park I (0-1) | 15-21 | Lost 3 |
| » Starters: Hal Griggs vs Early Wynn | Eighth | 12 out |
| Wednesday, May 28 |
| » Lost to White Sox (17-19), 13-3 | Comiskey Park I (0-2) | 15-22 | Lost 4 |
| » Starters: Chuck Stobbs vs Jim Wilson | Eighth | 12 out |
| Friday, May 30 |
| » Defeated Yankees (25-9), 13-8 | Yankee Stadium (2-3) | 16-22 | |
| » Starters: Russ Kemmerer vs Whitey Ford | Seventh | 10 out |
| » Defeated Yankees (25-10), 7-2 | Yankee Stadium (3-3) | 17-22 | Won 2 |
| » Starters: Pedro Ramos vs Bobby Shantz | Seventh | 10 out |
| Saturday, May 31 |
| » Lost to Orioles (16-21), 4-3 | Memorial Stadium (0-3) | 17-23 | |
| » Starters: Al Cicotte vs Billy O'Dell | Eighth | 11 out |
| Sunday, June 1 |
| » Defeated Orioles (16-22), 5-2 | Memorial Stadium (1-3) | 18-23 | |
| » Starters: Camilo Pascual vs Billy Loes | Seventh | 11 out |
| Monday, June 2 |
| » Defeated Orioles (16-23), 2-1 | Memorial Stadium (2-3) | 19-23 | Won 2 |
| » Starters: Hal Griggs vs Jack Harshman | Sixth | 11 out |
| Tuesday, June 3 |
| » Defeated Athletics (21-18), 5-4 | Griffith Stadium (11-9) | 20-23 | Won 3 |
| » Starters: Ralph Terry vs Russ Kemmerer | Third | 10½ out |
| » Defeated Athletics (21-19), 10-9 | Griffith Stadium (12-9) | 21-23 | Won 4 |
| » Starters: Ned Garver vs Pedro Ramos | Third | 10½ out |
| Wednesday, June 4 |
| » Lost to Athletics (22-19), 5-4 | Griffith Stadium (12-10) | 21-24 | |
| » Starters: Jack Urban vs Al Cicotte | Fifth | 10½ out |
| Thursday, June 5 |
| » Lost to Athletics (23-19), 2-0 | Griffith Stadium (12-11) | 21-25 | Lost 2 |
| » Starters: Ralph Terry vs Camilo Pascual | Sixth | 11 out |
| Friday, June 6 |
| » Lost to Tigers (21-25), 11-2 | Griffith Stadium (12-12) | 21-26 | Lost 3 |
| » Starters: Billy Hoeft vs Hal Griggs | Eighth | 12 out |
| Saturday, June 7 |
| » Defeated Tigers (21-26), 4-3 | Griffith Stadium (13-12) | 22-26 | |
| » Starters: Jim Bunning vs Russ Kemmerer | Fourth | 12 out |
| Sunday, June 8 |
| » Defeated Tigers (21-27), 4-3 | Griffith Stadium (14-12) | 23-26 | Won 2 |
| » Starters: George Susce vs Pedro Ramos | Fifth | 10½ out |
| Tuesday, June 10 |
| » Lost to White Sox (22-27), 5-4 | Griffith Stadium (14-13) | 23-27 | |
| » Starters: Ray Moore vs Camilo Pascual | Fifth | 10½ out |
| » Defeated White Sox (22-28), 5-2 | Griffith Stadium (15-13) | 24-27 | |
| » Starters: Jim Wilson vs Hal Griggs | Fifth | 10½ out |
| Wednesday, June 11 |
| » Defeated White Sox (22-29), 5-2 | Griffith Stadium (16-13) | 25-27 | Won 2 |
| » Starters: Bill Fischer vs Russ Kemmerer | Fourth | 11 out |
| Thursday, June 12 |
| » Defeated White Sox (22-30), 6-5 | Griffith Stadium (17-13) | 26-27 | Won 3 |
| » Starters: Dick Donovan vs Pedro Ramos | Fourth | 10½ out |
| Friday, June 13 |
| » Lost to Indians (26-30), 10-1 | Griffith Stadium (17-14) | 26-28 | |
| » Starters: Ray Narleski vs Chuck Stobbs | Fourth | 10½ out |
| Saturday, June 14 |
| » Lost to Indians (27-30), 10-2 | Griffith Stadium (17-15) | 26-29 | Lost 2 |
| » Starters: Cal McLish vs Hal Griggs | Fifth | 10½ out |
| Sunday, June 15 |
| » Lost to Indians (28-30), 5-3 | Griffith Stadium (17-16) | 26-30 | Lost 3 |
| » Starters: Gary Bell vs Russ Kemmerer | Sixth | 10½ out |
| » Lost to Indians (29-30), 4-2 | Griffith Stadium (17-17) | 26-31 | Lost 4 |
| » Starters: Jim Constable vs Tex Clevenger | Sixth | 10½ out |
| Tuesday, June 17 |
| » Lost to Tigers (28-29), 9-2 | Tiger Stadium (0-3) | 26-32 | Lost 5 |
| » Starters: Pedro Ramos vs Billy Hoeft | Eighth | 11½ out |
| Thursday, June 19 |
| » Defeated Tigers (28-30), 4-3 | Tiger Stadium (1-3) | 27-32 | |
| » Starters: Russ Kemmerer vs Paul Foytack | Seventh | 12 out |
| Saturday, June 21 |
| » Defeated Indians (29-34), 11-7 | Cleveland Stadium (2-2) | 28-32 | Won 2 |
| » Starters: Pedro Ramos vs Cal McLish | Fifth | 10½ out |
| Sunday, June 22 |
| » Lost to Indians (30-34), 4-3 | Cleveland Stadium (2-3) | 28-33 | |
| » Starters: Chuck Stobbs vs Ray Narleski | Eighth | 12 out |
| » Lost to Indians (31-34), 1-0 | Cleveland Stadium (2-4) | 28-34 | Lost 2 |
| » Starters: Hal Griggs vs Mudcat Grant | Eighth | 12 out |
| Monday, June 23 |
| » Lost to Athletics (32-30), 7-2 | Municipal Stadium (1-2) | 28-35 | Lost 3 |
| » Starters: Russ Kemmerer vs Murry Dickson | Eighth | 12 out |
| Tuesday, June 24 |
| » Tied Athletics, 2-2 | Municipal Stadium (1-2) | 28-35 | |
| » Starters: Tex Clevenger vs Ralph Terry | Eighth | 12½ out |
| Wednesday, June 25 |
| » Lost to Athletics (33-30), 4-3 | Municipal Stadium (1-3) | 28-36 | Lost 4 |
| » Starters: Pedro Ramos vs Ned Garver | Eighth | 13 out |
| Thursday, June 26 |
| » Lost to Athletics (34-30), 8-6 | Municipal Stadium (1-4) | 28-37 | Lost 5 |
| » Starters: Hal Griggs vs Wally Burnette | Eighth | 14 out |
| Friday, June 27 |
| » Lost to White Sox (31-34), 3-0 | Comiskey Park I (0-3) | 28-38 | Lost 6 |
| » Starters: Russ Kemmerer vs Billy Pierce | Eighth | 15 out |
| Saturday, June 28 |
| » Lost to White Sox (32-34), 8-4 | Comiskey Park I (0-4) | 28-39 | Lost 7 |
| » Starters: Tex Clevenger vs Jim Wilson | Eighth | 16 out |
| Sunday, June 29 |
| » Defeated White Sox (32-35), 12-0 | Comiskey Park I (1-4) | 29-39 | |
| » Starters: Pedro Ramos vs Ray Moore | Eighth | 15½ out |
| » Lost to White Sox (33-35), 12-11 | Comiskey Park I (1-5) | 29-40 | |
| » Starters: Jack Spring vs Early Wynn | Eighth | 15½ out |
| Tuesday, July 1 |
| » Lost to Red Sox (36-34), 10-5 | Fenway Park (2-2) | 29-41 | Lost 2 |
| » Starters: Hal Griggs vs Ike Delock | Eighth | 16 out |
| Wednesday, July 2 |
| » Defeated Red Sox (36-35), 5-3 | Fenway Park (3-2) | 30-41 | |
| » Starters: Camilo Pascual vs Tom Brewer | Eighth | 16 out |
| Thursday, July 3 |
| » Lost to Yankees (46-24), 11-3 | Griffith Stadium (17-18) | 30-42 | |
| » Starters: Whitey Ford vs Russ Kemmerer | Eighth | 17 out |
| Friday, July 4 |
| » Lost to Yankees (47-24), 2-1 | Griffith Stadium (17-19) | 30-43 | Lost 2 |
| » Starters: Bob Turley vs Pedro Ramos | Eighth | 19 out |
| » Lost to Yankees (48-24), 13-2 | Griffith Stadium (17-20) | 30-44 | Lost 3 |
| » Starters: Art Ditmar vs Tex Clevenger | Eighth | 19 out |
| Saturday, July 5 |
| » Lost to Orioles (35-39), 3-1 | Griffith Stadium (17-21) | 30-45 | Lost 4 |
| » Starters: Hal Brown vs Hal Griggs | Eighth | 19½ out |
| Sunday, July 6 |
| » Defeated Orioles (35-40), 4-3 | Griffith Stadium (18-21) | 31-45 | |
| » Starters: Jack Harshman vs Russ Kemmerer | Seventh | 18½ out |
| Thursday, July 10 |
| » Defeated Tigers (37-38), 5-3 | Griffith Stadium (19-21) | 32-45 | Won 2 |
| » Starters: Frank Lary vs Pedro Ramos | Eighth | 18½ out |
| Friday, July 11 |
| » Defeated Tigers (37-39), 6-5 | Griffith Stadium (20-21) | 33-45 | Won 3 |
| » Starters: Jim Bunning vs Russ Kemmerer | Eighth | 18½ out |
| Saturday, July 12 |
| » Lost to Tigers (38-39), 3-1 | Griffith Stadium (20-22) | 33-46 | |
| » Starters: Herm Wehmeier vs Hal Griggs | Seventh | 19½ out |
| Sunday, July 13 |
| » Defeated Athletics (38-40), 2-0 | Griffith Stadium (21-22) | 34-46 | |
| » Starters: Ralph Terry vs Camilo Pascual | Eighth | 18½ out |
| » Defeated Athletics (38-41), 4-2 | Griffith Stadium (22-22) | 35-46 | Won 2 |
| » Starters: Ned Garver vs John Romonosky | Eighth | 18½ out |
| Monday, July 14 |
| » Lost to Athletics (39-41), 4-0 | Griffith Stadium (22-23) | 35-47 | |
| » Starters: Jack Urban vs Pedro Ramos | Eighth | 19½ out |
| Tuesday, July 15 |
| » Defeated Indians (39-46), 5-4 | Griffith Stadium (23-23) | 36-47 | |
| » Starters: Herb Score vs Russ Kemmerer | Seventh | 18½ out |
| Wednesday, July 16 |
| » Defeated Indians (39-47), 7-6 | Griffith Stadium (24-23) | 37-47 | Won 2 |
| » Starters: Mudcat Grant vs Hal Griggs | Eighth | 18½ out |
| Thursday, July 17 |
| » Lost to Indians (40-47), 8-3 | Griffith Stadium (24-24) | 37-48 | |
| » Starters: Cal McLish vs Camilo Pascual | Eighth | 19½ out |
| Friday, July 18 |
| » Lost to White Sox (41-46), 9-2 | Griffith Stadium (24-25) | 37-49 | Lost 2 |
| » Starters: Early Wynn vs John Romonosky | Eighth | 19½ out |
| Saturday, July 19 |
| » Lost to White Sox (42-46), 7-6 | Griffith Stadium (24-26) | 37-50 | Lost 3 |
| » Starters: Jim Wilson vs Pedro Ramos | Seventh | 19½ out |
| Sunday, July 20 |
| » Lost to White Sox (43-46), 4-2 | Griffith Stadium (24-27) | 37-51 | Lost 4 |
| » Starters: Dick Donovan vs Russ Kemmerer | Eighth | 20½ out |
| » Defeated White Sox (43-47), 5-4 | Griffith Stadium (25-27) | 38-51 | |
| » Starters: Ray Moore vs Hal Griggs | Eighth | 20½ out |
| Tuesday, July 22 |
| » Defeated Indians (41-50), 4-2 | Cleveland Stadium (3-4) | 39-51 | Won 2 |
| » Starters: Camilo Pascual vs Cal McLish | Seventh | 21 out |
| » Lost to Indians (42-50), 5-3 | Cleveland Stadium (3-5) | 39-52 | |
| » Starters: John Romonosky vs Hal Woodeshick | Seventh | 21 out |
| Wednesday, July 23 |
| » Lost to Indians (43-50), 5-3 | Cleveland Stadium (3-6) | 39-53 | Lost 2 |
| » Starters: Pedro Ramos vs Mudcat Grant | Eighth | 22 out |
| Thursday, July 24 |
| » Lost to Indians (44-50), 6-1 | Cleveland Stadium (3-7) | 39-54 | Lost 3 |
| » Starters: Hal Griggs vs Gary Bell | Eighth | 23 out |
| Friday, July 25 |
| » Defeated Tigers (42-49), 4-3 | Tiger Stadium (2-3) | 40-54 | |
| » Starters: Russ Kemmerer vs George Susce | Eighth | 23 out |
| Saturday, July 26 |
| » Lost to Tigers (43-49), 9-1 | Tiger Stadium (2-4) | 40-55 | |
| » Starters: John Romonosky vs Herb Moford | Seventh | 24 out |
| Sunday, July 27 |
| » Defeated Tigers (43-50), 4-3 | Tiger Stadium (3-4) | 41-55 | |
| » Starters: Camilo Pascual vs Frank Lary | Eighth | 22 out |
| » Defeated Tigers (43-51), 6-1 | Tiger Stadium (4-4) | 42-55 | Won 2 |
| » Starters: Pedro Ramos vs Hank Aguirre | Eighth | 22 out |
| Monday, July 28 |
| » Lost to White Sox (47-50), 6-5 | Comiskey Park I (1-6) | 42-56 | |
| » Starters: Jim Constable vs Early Wynn | Eighth | 23 out |
| Tuesday, July 29 |
| » Lost to White Sox (48-50), 2-1 | Comiskey Park I (1-7) | 42-57 | Lost 2 |
| » Starters: Russ Kemmerer vs Dick Donovan | Eighth | 23 out |
| Wednesday, July 30 |
| » Lost to White Sox (49-50), 11-9 | Comiskey Park I (1-8) | 42-58 | Lost 3 |
| » Starters: John Romonosky vs Jim Wilson | Eighth | 23 out |
| Friday, August 1 |
| » Defeated Athletics (46-51), 10-4 | Municipal Stadium (2-4) | 43-58 | |
| » Starters: Pedro Ramos vs Bob Davis | Eighth | 23½ out |
| Saturday, August 2 |
| » Defeated Athletics (46-52), 6-3 | Municipal Stadium (3-4) | 44-58 | Won 2 |
| » Starters: Camilo Pascual vs Ned Garver | Eighth | 23½ out |
| Sunday, August 3 |
| » Lost to Athletics (47-52), 12-0 | Municipal Stadium (3-5) | 44-59 | |
| » Starters: Russ Kemmerer vs Ralph Terry | Eighth | 22½ out |
| » Defeated Athletics (47-53), 4-3 | Municipal Stadium (4-5) | 45-59 | |
| » Starters: Hal Griggs vs Jack Urban | Eighth | 22½ out |
| Tuesday, August 5 |
| » Lost to Red Sox (52-51), 7-1 | Fenway Park (3-3) | 45-60 | |
| » Starters: Camilo Pascual vs Bill Monbouquette | Seventh | 24 out |
| Wednesday, August 6 |
| » Lost to Red Sox (53-51), 8-2 | Fenway Park (3-4) | 45-61 | Lost 2 |
| » Starters: Pedro Ramos vs Tom Brewer | Seventh | 25 out |
| Thursday, August 7 |
| » Lost to Red Sox (54-51), 8-4 | Fenway Park (3-5) | 45-62 | Lost 3 |
| » Starters: Hal Griggs vs Frank Sullivan | Seventh | 25½ out |
| Friday, August 8 |
| » Defeated Orioles (47-56), 4-2 | Griffith Stadium (26-27) | 46-62 | |
| » Starters: Hal Brown vs Russ Kemmerer | Seventh | 25½ out |
| Saturday, August 9 |
| » Lost to Orioles (48-56), 12-5 | Griffith Stadium (26-28) | 46-63 | |
| » Starters: Arnie Portocarrero vs Camilo Pascual | Eighth | 25½ out |
| Sunday, August 10 |
| » Defeated Orioles (48-57), 6-2 | Griffith Stadium (27-28) | 47-63 | |
| » Starters: Milt Pappas vs Pedro Ramos | Eighth | 25½ out |
| » Lost to Orioles (49-57), 6-1 | Griffith Stadium (27-29) | 47-64 | |
| » Starters: Billy O'Dell vs Hal Griggs | Eighth | 25½ out |
| Monday, August 11 |
| » Defeated Red Sox (56-54), 6-3 | Griffith Stadium (28-29) | 48-64 | |
| » Starters: Bill Monbouquette vs Vito Valentinetti | Seventh | 24 out |
| Wednesday, August 13 |
| » Defeated Yankees (73-41), 9-4 | Yankee Stadium (4-3) | 49-64 | Won 2 |
| » Starters: Camilo Pascual vs Whitey Ford | Seventh | 23½ out |
| Friday, August 15 |
| » Defeated Orioles (52-59), 3-1 | Memorial Stadium (3-3) | 50-64 | Won 3 |
| » Starters: Vito Valentinetti vs Jack Harshman | Eighth | 23 out |
| Saturday, August 16 |
| » Lost to Orioles (53-59), 9-0 | Memorial Stadium (3-4) | 50-65 | |
| » Starters: Pedro Ramos vs Billy O'Dell | Eighth | 23 out |
| Sunday, August 17 |
| » Lost to Orioles (54-59), 2-1 | Memorial Stadium (3-5) | 50-66 | Lost 2 |
| » Starters: Russ Kemmerer vs Connie Johnson | Eighth | 23 out |
| Tuesday, August 19 |
| » Defeated Tigers (56-60), 3-1 | Griffith Stadium (29-29) | 51-66 | |
| » Starters: Herb Moford vs Camilo Pascual | Eighth | 22 out |
| Wednesday, August 20 |
| » Lost to Tigers (57-60), 7-1 | Griffith Stadium (29-30) | 51-67 | |
| » Starters: Frank Lary vs Pedro Ramos | Eighth | 23 out |
| Thursday, August 21 |
| » Lost to Athletics (55-64), 7-4 | Griffith Stadium (29-31) | 51-68 | Lost 2 |
| » Starters: Jack Urban vs Vito Valentinetti | Seventh | 24 out |
| Friday, August 22 |
| » Lost to Athletics (56-64), 1-0 | Griffith Stadium (29-32) | 51-69 | Lost 3 |
| » Starters: Ralph Terry vs Russ Kemmerer | Eighth | 25 out |
| Saturday, August 23 |
| » Lost to Athletics (57-64), 3-1 | Griffith Stadium (29-33) | 51-70 | Lost 4 |
| » Starters: Bob Grim vs Camilo Pascual | Seventh | 25 out |
| Sunday, August 24 |
| » Lost to Indians (59-65), 9-1 | Griffith Stadium (29-34) | 51-71 | Lost 5 |
| » Starters: Mudcat Grant vs Pedro Ramos | Eighth | 25½ out |
| Monday, August 25 |
| » Defeated Indians (59-66), 5-4 | Griffith Stadium (30-34) | 52-71 | |
| » Starters: Gary Bell vs Vito Valentinetti | Eighth | 25 out |
| Tuesday, August 26 |
| » Lost to White Sox (66-59), 5-2 | Griffith Stadium (30-35) | 52-72 | |
| » Starters: Early Wynn vs Russ Kemmerer | Eighth | 26 out |
| Wednesday, August 27 |
| » Lost to White Sox (67-59), 2-1 | Griffith Stadium (30-36) | 52-73 | Lost 2 |
| » Starters: Billy Pierce vs Camilo Pascual | Eighth | 26 out |
| Friday, August 29 |
| » Defeated Yankees (79-49), 3-0 | Griffith Stadium (31-36) | 53-73 | |
| » Starters: Whitey Ford vs Pedro Ramos | Eighth | 25 out |
| Saturday, August 30 |
| » Defeated Yankees (79-50), 3-1 | Griffith Stadium (32-36) | 54-73 | Won 2 |
| » Starters: Art Ditmar vs Vito Valentinetti | Eighth | 24 out |
| Sunday, August 31 |
| » Lost to Yankees (80-50), 7-6 | Griffith Stadium (32-37) | 54-74 | |
| » Starters: Bob Turley vs Russ Kemmerer | Eighth | 25 out |
| Monday, September 1 |
| » Lost to Orioles (63-65), 2-0 | Griffith Stadium (32-38) | 54-75 | Lost 2 |
| » Starters: Jack Harshman vs Camilo Pascual | Eighth | 26 out |
| » Lost to Orioles (64-65), 10-1 | Griffith Stadium (32-39) | 54-76 | Lost 3 |
| » Starters: Billy O'Dell vs Jim Constable | Eighth | 26 out |
| Tuesday, September 2 |
| » Defeated Orioles (64-66), 4-3 | Griffith Stadium (33-39) | 55-76 | |
| » Starters: Hal Brown vs Pedro Ramos | Seventh | 26 out |
| » Major-league debuts: Jerry Adair (Orioles) |
| Wednesday, September 3 |
| » Lost to Orioles (65-66), 4-3 | Griffith Stadium (33-40) | 55-77 | |
| » Starters: Arnie Portocarrero vs Vito Valentinetti | Eighth | 27 out |
| Thursday, September 4 |
| Former Senator Red Killefer dies in Los Angeles, CA at the age of 74. |
| Friday, September 5 |
| » Defeated Yankees (83-52), 6-3 | Yankee Stadium (5-3) | 56-77 | |
| » Starters: Russ Kemmerer vs Bob Turley | Eighth | 26 out |
| Saturday, September 6 |
| » Defeated Yankees (83-53), 8-3 | Yankee Stadium (6-3) | 57-77 | Won 2 |
| » Starters: Camilo Pascual vs Art Ditmar | Seventh | 25 out |
| » Major-league debuts: Johnny James (Yankees) |
| Sunday, September 7 |
| » Defeated Yankees (83-54), 1-0 | Yankee Stadium (7-3) | 58-77 | Won 3 |
| » Starters: Pedro Ramos vs Bobby Shantz | Seventh | 25 out |
| » Lost to Yankees (84-54), 7-0 | Yankee Stadium (7-4) | 58-78 | |
| » Starters: Vito Valentinetti vs Duke Maas | Seventh | 25 out |
| Tuesday, September 9 |
| » Lost to Tigers (67-69), 7-1 | Tiger Stadium (4-5) | 58-79 | Lost 2 |
| » Starters: Hal Griggs vs Jim Bunning | Eighth | 25 out |
| Wednesday, September 10 |
| » Defeated Tigers (67-70), 5-4 | Tiger Stadium (5-5) | 59-79 | |
| » Starters: Russ Kemmerer vs Paul Foytack | Eighth | 25 out |
| Thursday, September 11 |
| » Defeated Tigers (67-71), 7-6 | Tiger Stadium (6-5) | 60-79 | Won 2 |
| » Starters: Camilo Pascual vs Herb Moford | Eighth | 24½ out |
| » Major-league debuts: George Alusik (Tigers) |
| Friday, September 12 |
| » Lost to Athletics (67-73), 4-3 | Municipal Stadium (4-6) | 60-80 | |
| » Starters: Pedro Ramos vs Ray Herbert | Eighth | 25½ out |
| Saturday, September 13 |
| » Defeated Athletics (67-74), 8-5 | Municipal Stadium (5-6) | 61-80 | |
| » Starters: Vito Valentinetti vs Jack Urban | Eighth | 25½ out |
| Sunday, September 14 |
| » Lost to White Sox (75-67), 7-1 | Comiskey Park I (1-9) | 61-81 | |
| » Starters: Bill Fischer vs Billy Pierce | Eighth | 27½ out |
| » Lost to White Sox (76-67), 6-5 | Comiskey Park I (1-10) | 61-82 | Lost 2 |
| » Starters: Russ Kemmerer vs Jim Wilson | Eighth | 27½ out |
| Tuesday, September 16 |
| » Lost to Indians (71-73), 5-1 | Cleveland Stadium (3-8) | 61-83 | Lost 3 |
| » Starters: Pedro Ramos vs Gary Bell | Seventh | 27½ out |
| » Major-league debuts: Bob Allison (Senators) |
| Friday, September 19 |
| » Lost to Red Sox (72-74), 2-0 | Fenway Park (3-6) | 61-84 | Lost 4 |
| » Starters: Camilo Pascual vs Tom Brewer | Eighth | 27 out |
| Saturday, September 20 |
| » Lost to Red Sox (73-74), 2-0 | Fenway Park (3-7) | 61-85 | Lost 5 |
| » Starters: Vito Valentinetti vs Frank Sullivan | Seventh | 27 out |
| Sunday, September 21 |
| » Lost to Red Sox (74-74), 2-0 | Fenway Park (3-8) | 61-86 | Lost 6 |
| » Starters: Bill Fischer vs Ike Delock | Sixth | 27 out |
| Monday, September 22 |
| » Lost to Orioles (71-77), 2-0 | Memorial Stadium (3-6) | 61-87 | Lost 7 |
| » Starters: Russ Kemmerer vs Hal Brown | Sixth | 27½ out |
| Tuesday, September 23 |
| » Lost to Orioles (72-77), 3-2 | Memorial Stadium (3-7) | 61-88 | Lost 8 |
| » Starters: Pedro Ramos vs Jack Harshman | Sixth | 27½ out |
| Wednesday, September 24 |
| » Lost to Orioles (73-77), 2-0 | Memorial Stadium (3-8) | 61-89 | Lost 9 |
| » Starters: Camilo Pascual vs Arnie Portocarrero | Sixth | 28½ out |
| Friday, September 26 |
| » Lost to Red Sox (76-75), 6-4 | Griffith Stadium (33-41) | 61-90 | Lost 10 |
| » Starters: Ike Delock vs Vito Valentinetti | Eighth | 29 out |
| » Lost to Red Sox (77-75), 3-1 | Griffith Stadium (33-42) | 61-91 | Lost 11 |
| » Starters: Frank Sullivan vs Bill Fischer | Eighth | 29 out |
| Saturday, September 27 |
| » Lost to Red Sox (78-75), 9-5 | Griffith Stadium (33-43) | 61-92 | Lost 12 |
| » Starters: Dave Sisler vs Pedro Ramos | Eighth | 29½ out |
| Sunday, September 28 |
| » Lost to Red Sox (79-75), 6-4 | Griffith Stadium (33-44) | 61-93 | Lost 13 |
| » Starters: Tom Brewer vs Pedro Ramos | Eighth | 31 out |
| Monday, December 8 |
| Former Senator Tris Speaker dies in Lake Whitney, TX at the age of 71. |
Game information provided by Retrosheet (www.retrosheet.org) |
