| Monday, March 24 |
| Future Red Sox Bruce Hurst is born in St. George, UT. |
| Tuesday, March 25 |
| Former Red Sox Al Shaw dies in Uhrichsville, OH at the age of 84. |
| Monday, April 14 |
| » Lost to Senators (1-0), 5-2 | Griffith Stadium (0-1) | 0-1 | |
| » Starters: Frank Sullivan vs Pedro Ramos | Third | 1 out |
| » Major-league debuts: Albie Pearson (Senators) |
| Tuesday, April 15 |
| » Lost to Yankees (1-0), 3-0 | Fenway Park (0-1) | 0-2 | Lost 2 |
| » Starters: Don Larsen vs Willard Nixon | Fourth | 1½ out |
| Wednesday, April 16 |
| » Defeated Yankees (1-1), 3-1 | Fenway Park (1-1) | 1-2 | |
| » Starters: Tom Sturdivant vs Dave Sisler | Fourth | 1½ out |
| Thursday, April 17 |
| » Lost to Yankees (2-1), 3-1 | Fenway Park (1-2) | 1-3 | |
| » Starters: Johnny Kucks vs Tom Brewer | Fourth | 2 out |
| Saturday, April 19 |
| » Lost to Senators (2-2), 4-3 | Griffith Stadium (0-2) | 1-4 | Lost 2 |
| » Starters: Mike Fornieles vs Pedro Ramos | Fifth | 3 out |
| Sunday, April 20 |
| » Lost to Senators (3-2), 6-5 | Griffith Stadium (0-3) | 1-5 | Lost 3 |
| » Starters: Frank Sullivan vs Camilo Pascual | Fifth | 4 out |
| » Major-league debuts: Al Schroll (Red Sox) |
| Monday, April 21 |
| » Lost to Yankees (6-1), 4-1 | Yankee Stadium (0-1) | 1-6 | Lost 4 |
| » Starters: Willard Nixon vs Don Larsen | Eighth | 5 out |
| Tuesday, April 22 |
| » Lost to Yankees (7-1), 12-7 | Yankee Stadium (0-2) | 1-7 | Lost 5 |
| » Starters: Dave Sisler vs Tom Sturdivant | Seventh | 6 out |
| Wednesday, April 23 |
| » Defeated Orioles (3-4), 7-5 | Fenway Park (2-2) | 2-7 | |
| » Starters: Hal Brown vs Tom Brewer | Eighth | 5 out |
| Thursday, April 24 |
| » Defeated Orioles (3-5), 4-3 | Fenway Park (3-2) | 3-7 | Won 2 |
| » Starters: Milt Pappas vs Mike Fornieles | Seventh | 4½ out |
| Friday, April 25 |
| » Lost to Senators (5-3), 2-0 | Fenway Park (3-3) | 3-8 | |
| » Starters: Pedro Ramos vs Frank Baumann | Seventh | 4½ out |
| Saturday, April 26 |
| » Lost to Senators (6-3), 7-5 | Fenway Park (3-4) | 3-9 | Lost 2 |
| » Starters: Hal Griggs vs Willard Nixon | Eighth | 5½ out |
| Sunday, April 27 |
| » Defeated Senators (6-4), 7-5 | Fenway Park (4-4) | 4-9 | |
| » Starters: Russ Kemmerer vs Dave Sisler | Sixth | 5 out |
| Tuesday, April 29 |
| Future Red Sox Steve Crawford is born in Pryor, OK. |
| Wednesday, April 30 |
| » Lost to Athletics (8-4), 11-4 | Fenway Park (4-5) | 4-10 | |
| » Starters: Ned Garver vs Tom Brewer | Seventh | 5½ out |
| Thursday, May 1 |
| » Defeated Athletics (8-5), 7-6 | Fenway Park (5-5) | 5-10 | |
| » Starters: Wally Burnette vs Mike Fornieles | Sixth | 5 out |
| Friday, May 2 |
| » Defeated Tigers (8-8), 6-0 | Fenway Park (6-5) | 6-10 | Won 2 |
| » Starters: Jim Bunning vs Dave Sisler | Seventh | 5 out |
| Sunday, May 4 |
| » Lost to Indians (10-8), 2-1 | Fenway Park (6-6) | 6-11 | |
| » Starters: Bob Kelly vs Tom Brewer | Seventh | 5 out |
| » Defeated Indians (10-9), 2-1 | Fenway Park (7-6) | 7-11 | |
| » Starters: Hoyt Wilhelm vs Frank Baumann | Seventh | 5 out |
| Monday, May 5 |
| » Defeated Indians (10-10), 8-5 | Fenway Park (8-6) | 8-11 | Won 2 |
| » Starters: Ray Narleski vs Bob Smith | Seventh | 4½ out |
| Tuesday, May 6 |
| » Defeated White Sox (4-11), 7-5 | Fenway Park (9-6) | 9-11 | Won 3 |
| » Starters: Billy Pierce vs Mike Fornieles | Sixth | 4 out |
| Friday, May 9 |
| » Defeated Orioles (8-9), 13-5 | Memorial Stadium (1-0) | 10-11 | Won 4 |
| » Starters: Dave Sisler vs Billy O'Dell | Fourth | 4 out |
| Saturday, May 10 |
| » Lost to Orioles (9-9), 5-2 | Memorial Stadium (1-1) | 10-12 | |
| » Starters: Tom Brewer vs Jack Harshman | Sixth | 5 out |
| Sunday, May 11 |
| » Lost to Orioles (10-9), 3-2 | Memorial Stadium (1-2) | 10-13 | Lost 2 |
| » Starters: Frank Baumann vs Billy Loes | Seventh | 6 out |
| » Lost to Orioles (11-9), 4-0 | Memorial Stadium (1-3) | 10-14 | Lost 3 |
| » Starters: Willard Nixon vs Arnie Portocarrero | Seventh | 6 out |
| Monday, May 12 |
| » Lost to Senators (13-9), 5-4 | Griffith Stadium (0-4) | 10-15 | Lost 4 |
| » Starters: Frank Sullivan vs Hal Griggs | Seventh | 6½ out |
| Tuesday, May 13 |
| » Defeated Senators (13-10), 9-6 | Griffith Stadium (1-4) | 11-15 | |
| » Starters: Bob Smith vs Pedro Ramos | Seventh | 6½ out |
| Wednesday, May 14 |
| » Defeated Senators (13-11), 7-5 | Griffith Stadium (2-4) | 12-15 | Won 2 |
| » Starters: Dave Sisler vs Ralph Lumenti | Sixth | 6½ out |
| Saturday, May 17 |
| » Defeated Orioles (11-12), 7-4 | Fenway Park (10-6) | 13-15 | Won 3 |
| » Starters: Jack Harshman vs Tom Brewer | Fourth | 7½ out |
| » Lost to Orioles (12-12), 5-3 | Fenway Park (10-7) | 13-16 | |
| » Starters: Arnie Portocarrero vs Frank Baumann | Fourth | 7½ out |
| Sunday, May 18 |
| » Defeated Orioles (12-13), 8-4 | Fenway Park (11-7) | 14-16 | |
| » Starters: Billy Loes vs Frank Sullivan | Fifth | 8 out |
| Tuesday, May 20 |
| » Defeated Indians (15-17), 6-1 | Cleveland Stadium (1-0) | 15-16 | Won 2 |
| » Starters: Bob Smith vs Ray Narleski | Fourth | 8 out |
| Wednesday, May 21 |
| » Lost to Indians (16-17), 3-2 | Cleveland Stadium (1-1) | 15-17 | |
| » Starters: Dave Sisler vs Dick Tomanek | Fourth | 9 out |
| Thursday, May 22 |
| » Defeated Athletics (14-14), 8-5 | Municipal Stadium (1-0) | 16-17 | |
| » Starters: Tom Brewer vs Jack Urban | Fourth | 9 out |
| Friday, May 23 |
| » Defeated Athletics (14-15), 9-1 | Municipal Stadium (2-0) | 17-17 | Won 2 |
| » Starters: Willard Nixon vs Duke Maas | Third | 9 out |
| Saturday, May 24 |
| » Defeated Athletics (14-16), 5-4 | Municipal Stadium (3-0) | 18-17 | Won 3 |
| » Starters: Frank Sullivan vs Alex Kellner | Second | 8 out |
| Sunday, May 25 |
| » Defeated White Sox (14-19), 6-3 | Comiskey Park I (1-0) | 19-17 | Won 4 |
| » Starters: Frank Baumann vs Dick Donovan | Second | 9 out |
| » Lost to White Sox (15-19), 4-3 | Comiskey Park I (1-1) | 19-18 | |
| » Starters: Bob Smith vs Billy Pierce | Second | 9 out |
| Tuesday, May 27 |
| » Lost to Tigers (17-21), 3-2 | Tiger Stadium (0-1) | 19-19 | Lost 2 |
| » Starters: Tom Brewer vs Paul Foytack | Third | 9 out |
| Wednesday, May 28 |
| » Lost to Tigers (18-21), 4-2 | Tiger Stadium (0-2) | 19-20 | Lost 3 |
| » Starters: Willard Nixon vs Frank Lary | Fourth | 9 out |
| Thursday, May 29 |
| Future Red Sox Mike Stenhouse is born in Pueblo, CO. |
| Friday, May 30 |
| » Defeated Orioles (14-21), 2-0 | Memorial Stadium (2-3) | 20-20 | |
| » Starters: Frank Sullivan vs Connie Johnson | Fifth | 8 out |
| » Lost to Orioles (15-21), 2-0 | Memorial Stadium (2-4) | 20-21 | |
| » Starters: Bob Smith vs Arnie Portocarrero | Fifth | 8 out |
| Saturday, May 31 |
| » Lost to Yankees (26-10), 5-4 | Fenway Park (11-8) | 20-22 | Lost 2 |
| » Starters: Don Larsen vs Dave Sisler | Fifth | 9 out |
| Sunday, June 1 |
| » Lost to Yankees (27-10), 10-4 | Fenway Park (11-9) | 20-23 | Lost 3 |
| » Starters: Bob Turley vs Frank Baumann | Fifth | 10 out |
| Tuesday, June 3 |
| » Defeated Indians (21-24), 7-3 | Fenway Park (12-9) | 21-23 | |
| » Starters: Mudcat Grant vs Tom Brewer | Third | 10½ out |
| Wednesday, June 4 |
| » Lost to Indians (22-24), 7-5 | Fenway Park (12-10) | 21-24 | |
| » Starters: Ray Narleski vs Frank Sullivan | Fifth | 10½ out |
| Thursday, June 5 |
| » Defeated Indians (22-25), 5-3 | Fenway Park (13-10) | 22-24 | |
| » Starters: Gary Bell vs Bob Smith | Third | 10 out |
| Friday, June 6 |
| » Defeated White Sox (21-24), 3-2 | Fenway Park (14-10) | 23-24 | Won 2 |
| » Starters: Jim Wilson vs Willard Nixon | Third | 10 out |
| Saturday, June 7 |
| » Defeated White Sox (21-25), 7-6 | Fenway Park (15-10) | 24-24 | Won 3 |
| » Starters: Bob Keegan vs Frank Baumann | Third | 10 out |
| Sunday, June 8 |
| » Defeated White Sox (21-26), 6-5 | Fenway Park (16-10) | 25-24 | Won 4 |
| » Starters: Billy Pierce vs Tom Brewer | Third | 8 out |
| » Defeated White Sox (21-27), 4-1 | Fenway Park (17-10) | 26-24 | Won 5 |
| » Starters: Dick Donovan vs Dave Sisler | Third | 8 out |
| Monday, June 9 |
| » Defeated Tigers (21-28), 9-4 | Fenway Park (18-10) | 27-24 | Won 6 |
| » Starters: Paul Foytack vs Frank Sullivan | Third | 7½ out |
| Wednesday, June 11 |
| » Lost to Tigers (22-28), 7-0 | Fenway Park (18-11) | 27-25 | |
| » Starters: Frank Lary vs Mike Fornieles | Third | 9½ out |
| » Lost to Tigers (23-28), 9-3 | Fenway Park (18-12) | 27-26 | Lost 2 |
| » Starters: Jim Bunning vs Murray Wall | Third | 9½ out |
| Thursday, June 12 |
| » Defeated Tigers (23-29), 4-2 | Fenway Park (19-12) | 28-26 | |
| » Starters: Paul Foytack vs Dave Sisler | Second | 9 out |
| Friday, June 13 |
| » Defeated Athletics (26-26), 9-3 | Fenway Park (20-12) | 29-26 | Won 2 |
| » Starters: Ned Garver vs Tom Brewer | Second | 8 out |
| Saturday, June 14 |
| » Defeated Athletics (26-27), 7-1 | Fenway Park (21-12) | 30-26 | Won 3 |
| » Starters: Jack Urban vs Frank Sullivan | Second | 7 out |
| Sunday, June 15 |
| » Lost to Athletics (27-27), 17-6 | Fenway Park (21-13) | 30-27 | |
| » Starters: Ralph Terry vs Willard Nixon | Second | 7 out |
| » Lost to Athletics (28-27), 9-4 | Fenway Park (21-14) | 30-28 | Lost 2 |
| » Starters: Duke Maas vs Mike Fornieles | Second | 7 out |
| Future Red Sox Wade Boggs is born in Omaha, NE. |
| Tuesday, June 17 |
| » Lost to White Sox (26-30), 4-0 | Comiskey Park I (1-2) | 30-29 | Lost 3 |
| » Starters: Dave Sisler vs Billy Pierce | Second | 8 out |
| Wednesday, June 18 |
| » Defeated White Sox (26-31), 13-9 | Comiskey Park I (2-2) | 31-29 | |
| » Starters: Tom Brewer vs Ray Moore | Second | 8 out |
| » Major-league debuts: Norm Cash (White Sox) |
| Thursday, June 19 |
| » Lost to White Sox (27-31), 4-0 | Comiskey Park I (2-3) | 31-30 | |
| » Starters: Frank Sullivan vs Early Wynn | Second | 9 out |
| Friday, June 20 |
| » Lost to Athletics (29-30), 5-3 | Municipal Stadium (3-1) | 31-31 | Lost 2 |
| » Starters: Bob Smith vs Ralph Terry | Second | 9 out |
| Saturday, June 21 |
| » Lost to Athletics (30-30), 8-5 | Municipal Stadium (3-2) | 31-32 | Lost 3 |
| » Starters: Dave Sisler vs Ray Herbert | Third | 9 out |
| Sunday, June 22 |
| » Lost to Athletics (31-30), 2-1 | Municipal Stadium (3-3) | 31-33 | Lost 4 |
| » Starters: Tom Brewer vs Jack Urban | Fourth | 10 out |
| Monday, June 23 |
| Future Red Sox Marty Barrett is born in Arcadia, CA. |
| Tuesday, June 24 |
| » Defeated Indians (31-35), 4-3 | Cleveland Stadium (2-1) | 32-33 | |
| » Starters: Frank Sullivan vs Gary Bell | Fourth | 9½ out |
| Thursday, June 26 |
| » Defeated Indians (31-36), 2-1 | Cleveland Stadium (3-1) | 33-33 | Won 2 |
| » Starters: Ike Delock vs Cal McLish | Fourth | 9½ out |
| Friday, June 27 |
| » Lost to Tigers (33-32), 7-4 | Tiger Stadium (0-3) | 33-34 | |
| » Starters: Tom Brewer vs Frank Lary | Fourth | 10½ out |
| Saturday, June 28 |
| » Defeated Tigers (33-33), 6-5 | Tiger Stadium (1-3) | 34-34 | |
| » Starters: Dave Sisler vs Jim Bunning | Fourth | 10½ out |
| Sunday, June 29 |
| » Defeated Tigers (33-34), 10-7 | Tiger Stadium (2-3) | 35-34 | Won 2 |
| » Starters: Frank Sullivan vs Paul Foytack | Third | 9½ out |
| Tuesday, July 1 |
| » Defeated Senators (29-41), 10-5 | Fenway Park (22-14) | 36-34 | Won 3 |
| » Starters: Hal Griggs vs Ike Delock | Third | 9 out |
| Wednesday, July 2 |
| » Lost to Senators (30-41), 5-3 | Fenway Park (22-15) | 36-35 | |
| » Starters: Camilo Pascual vs Tom Brewer | Third | 10 out |
| Thursday, July 3 |
| » Lost to Orioles (33-38), 7-5 | Fenway Park (22-16) | 36-36 | Lost 2 |
| » Starters: Charlie Beamon vs Duane Wilson | Fourth | 11 out |
| Friday, July 4 |
| » Defeated Orioles (33-39), 5-1 | Fenway Park (23-16) | 37-36 | |
| » Starters: Milt Pappas vs Frank Sullivan | Fourth | 12 out |
| » Lost to Orioles (34-39), 5-3 | Fenway Park (23-17) | 37-37 | |
| » Starters: Arnie Portocarrero vs Mike Fornieles | Fourth | 12 out |
| Saturday, July 5 |
| » Tied Yankees, 3-3 | Yankee Stadium (0-2) | 37-37 | |
| » Starters: Dave Sisler vs Duke Maas | Third | 12 out |
| Sunday, July 6 |
| » Defeated Yankees (48-25), 10-4 | Yankee Stadium (1-2) | 38-37 | |
| » Starters: Ike Delock vs Don Larsen | Second | 11 out |
| Monday, July 7 |
| Future Red Sox Glenn Hoffman is born in Orange, CA. |
| Thursday, July 10 |
| » Defeated White Sox (36-40), 11-2 | Fenway Park (24-17) | 39-37 | Won 2 |
| » Starters: Early Wynn vs Frank Sullivan | Second | 11 out |
| Friday, July 11 |
| » Defeated White Sox (36-41), 6-1 | Fenway Park (25-17) | 40-37 | Won 3 |
| » Starters: Jim Wilson vs Ike Delock | Second | 11 out |
| Saturday, July 12 |
| » Lost to White Sox (37-41), 7-4 | Fenway Park (25-18) | 40-38 | |
| » Starters: Dick Donovan vs Dave Sisler | Second | 12½ out |
| » Lost to White Sox (38-41), 13-5 | Fenway Park (25-19) | 40-39 | Lost 2 |
| » Starters: Bob Shaw vs Duane Wilson | Second | 12½ out |
| Sunday, July 13 |
| » Lost to Indians (39-44), 9-4 | Fenway Park (25-20) | 40-40 | Lost 3 |
| » Starters: Cal McLish vs Tom Brewer | Third | 13 out |
| Monday, July 14 |
| » Defeated Indians (39-45), 4-3 | Fenway Park (26-20) | 41-40 | |
| » Starters: Hoyt Wilhelm vs Dave Sisler | Second | 13 out |
| Tuesday, July 15 |
| » Defeated Athletics (39-42), 5-2 | Fenway Park (27-20) | 42-40 | Won 2 |
| » Starters: Ray Herbert vs Frank Sullivan | Second | 12 out |
| Wednesday, July 16 |
| » Defeated Athletics (39-43), 5-2 | Fenway Park (28-20) | 43-40 | Won 3 |
| » Starters: Murry Dickson vs Ike Delock | Second | 12 out |
| Thursday, July 17 |
| » Defeated Athletics (39-44), 6-2 | Fenway Park (29-20) | 44-40 | Won 4 |
| » Starters: Tom Gorman vs Tom Brewer | Second | 12 out |
| Friday, July 18 |
| » Defeated Tigers (41-43), 11-9 | Fenway Park (30-20) | 45-40 | Won 5 |
| » Starters: Paul Foytack vs Bill Monbouquette | Second | 11 out |
| » Major-league debuts: Bill Monboquette (Red Sox) |
| Saturday, July 19 |
| » Defeated Tigers (41-44), 7-6 | Fenway Park (31-20) | 46-40 | Won 6 |
| » Starters: Frank Lary vs Dave Sisler | Second | 10 out |
| Sunday, July 20 |
| » Lost to Tigers (42-44), 3-0 | Fenway Park (31-21) | 46-41 | |
| » Starters: Jim Bunning vs Frank Sullivan | Second | 11 out |
| » Defeated Tigers (42-45), 5-2 | Fenway Park (32-21) | 47-41 | |
| » Starters: George Susce vs Ike Delock | Second | 11 out |
| » Major-league debuts: Ted Bowsfield (Red Sox) |
| Monday, July 21 |
| Future Red Sox Dave Henderson is born in Merced, CA. |
| Tuesday, July 22 |
| » Lost to Athletics (42-46), 4-3 | Municipal Stadium (3-4) | 47-42 | |
| » Starters: Tom Brewer vs Murry Dickson | Second | 12 out |
| Wednesday, July 23 |
| » Lost to Athletics (43-46), 3-1 | Municipal Stadium (3-5) | 47-43 | Lost 2 |
| » Starters: Bill Monbouquette vs Ralph Terry | Second | 13 out |
| Friday, July 25 |
| » Lost to White Sox (45-49), 4-0 | Comiskey Park I (2-4) | 47-44 | Lost 3 |
| » Starters: Frank Sullivan vs Dick Donovan | Second | 14½ out |
| Future Red Sox Marc Sullivan is born in Quincy, MA. |
| Saturday, July 26 |
| » Lost to White Sox (46-49), 11-6 | Comiskey Park I (2-5) | 47-45 | Lost 4 |
| » Starters: Ike Delock vs Ray Moore | Second | 15½ out |
| Sunday, July 27 |
| » Defeated White Sox (46-50), 7-3 | Comiskey Park I (3-5) | 48-45 | |
| » Starters: Tom Brewer vs Billy Pierce | Second | 14 out |
| Monday, July 28 |
| » Lost to Tigers (44-51), 5-4 | Tiger Stadium (2-4) | 48-46 | |
| » Starters: Dave Sisler vs Al Cicotte | Second | 15 out |
| Tuesday, July 29 |
| » Defeated Tigers (44-52), 11-8 | Tiger Stadium (3-4) | 49-46 | |
| » Starters: Frank Sullivan vs Jim Bunning | Second | 14 out |
| Wednesday, July 30 |
| » Lost to Tigers (45-52), 2-1 | Tiger Stadium (3-5) | 49-47 | |
| » Starters: Ike Delock vs George Susce | Second | 14 out |
| » Major-league debuts: Coot Veal (Tigers) |
| Future Red Sox Scott Fletcher is born in Fort Walton Beach, FL. |
| Thursday, July 31 |
| » Lost to Tigers (46-52), 3-2 | Tiger Stadium (3-6) | 49-48 | Lost 2 |
| » Starters: Bill Monbouquette vs Frank Lary | Second | 15 out |
| Friday, August 1 |
| » Lost to Indians (49-52), 7-1 | Cleveland Stadium (3-2) | 49-49 | Lost 3 |
| » Starters: Frank Sullivan vs Cal McLish | Second | 16½ out |
| » Lost to Indians (50-52), 3-1 | Cleveland Stadium (3-3) | 49-50 | Lost 4 |
| » Starters: Dave Sisler vs Hal Woodeshick | Second | 16½ out |
| Former Red Sox Ike Boone dies in Northport, AL at the age of 62. |
| Saturday, August 2 |
| » Lost to Indians (51-52), 4-1 | Cleveland Stadium (3-4) | 49-51 | Lost 5 |
| » Starters: Tom Brewer vs Mudcat Grant | Third | 17½ out |
| Sunday, August 3 |
| » Defeated Indians (51-53), 3-2 | Cleveland Stadium (4-4) | 50-51 | |
| » Starters: Ike Delock vs Gary Bell | Second | 15½ out |
| » Defeated Indians (51-54), 4-2 | Cleveland Stadium (5-4) | 51-51 | Won 2 |
| » Starters: Ted Bowsfield vs Ray Narleski | Second | 15½ out |
| Tuesday, August 5 |
| » Defeated Senators (45-60), 7-1 | Fenway Park (33-21) | 52-51 | Won 3 |
| » Starters: Camilo Pascual vs Bill Monbouquette | Second | 16 out |
| Future Red Sox Reid Nichols is born in Ocala, FL. |
| Wednesday, August 6 |
| » Defeated Senators (45-61), 8-2 | Fenway Park (34-21) | 53-51 | Won 4 |
| » Starters: Pedro Ramos vs Tom Brewer | Second | 16 out |
| Thursday, August 7 |
| » Defeated Senators (45-62), 8-4 | Fenway Park (35-21) | 54-51 | Won 5 |
| » Starters: Hal Griggs vs Frank Sullivan | Second | 15½ out |
| Friday, August 8 |
| » Lost to Yankees (71-36), 2-0 | Yankee Stadium (1-3) | 54-52 | |
| » Starters: Ike Delock vs Whitey Ford | Second | 16½ out |
| Saturday, August 9 |
| » Defeated Yankees (71-37), 9-6 | Yankee Stadium (2-3) | 55-52 | |
| » Starters: Dave Sisler vs Duke Maas | Second | 15½ out |
| Future Red Sox Matt Young is born in Pasadena, CA. |
| Sunday, August 10 |
| » Lost to Yankees (72-37), 7-5 | Yankee Stadium (2-4) | 55-53 | |
| » Starters: Tom Brewer vs Don Larsen | Second | 15½ out |
| » Defeated Yankees (72-38), 9-3 | Yankee Stadium (3-4) | 56-53 | |
| » Starters: Ted Bowsfield vs Bob Turley | Second | 15½ out |
| Monday, August 11 |
| » Lost to Senators (48-64), 6-3 | Griffith Stadium (2-5) | 56-54 | |
| » Starters: Bill Monbouquette vs Vito Valentinetti | Second | 15 out |
| Wednesday, August 13 |
| » Lost to Orioles (52-58), 2-1 | Memorial Stadium (2-5) | 56-55 | Lost 2 |
| » Starters: Frank Sullivan vs Arnie Portocarrero | Third | 15½ out |
| Thursday, August 14 |
| » Lost to Yankees (74-41), 8-2 | Fenway Park (35-22) | 56-56 | Lost 3 |
| » Starters: Duke Maas vs Dave Sisler | Third | 16½ out |
| Friday, August 15 |
| » Defeated Yankees (74-42), 6-2 | Fenway Park (36-22) | 57-56 | |
| » Starters: Bob Turley vs Ted Bowsfield | Third | 15½ out |
| Saturday, August 16 |
| » Defeated Yankees (74-43), 7-4 | Fenway Park (37-22) | 58-56 | Won 2 |
| » Starters: Don Larsen vs Tom Brewer | Third | 14½ out |
| Sunday, August 17 |
| » Defeated Yankees (74-44), 6-5 | Fenway Park (38-22) | 59-56 | Won 3 |
| » Starters: Art Ditmar vs Ike Delock | Third | 13½ out |
| Tuesday, August 19 |
| » Lost to White Sox (63-55), 7-1 | Fenway Park (38-23) | 59-57 | |
| » Starters: Dick Donovan vs Frank Sullivan | Third | 13½ out |
| Future Red Sox Gary Gaetti is born in Centralia, IL. |
| Wednesday, August 20 |
| » Lost to White Sox (64-55), 10-8 | Fenway Park (38-24) | 59-58 | Lost 2 |
| » Starters: Jim Wilson vs Ted Bowsfield | Third | 14½ out |
| Thursday, August 21 |
| » Defeated Indians (57-64), 8-6 | Fenway Park (39-24) | 60-58 | |
| » Starters: Hal Woodeshick vs Tom Brewer | Third | 14½ out |
| Friday, August 22 |
| » Defeated Indians (57-65), 4-3 | Fenway Park (40-24) | 61-58 | Won 2 |
| » Starters: Hoyt Wilhelm vs Ike Delock | Third | 14½ out |
| Saturday, August 23 |
| » Lost to Indians (58-65), 8-1 | Fenway Park (40-25) | 61-59 | |
| » Starters: Cal McLish vs Dave Sisler | Third | 14½ out |
| Sunday, August 24 |
| » Defeated Athletics (57-65), 14-3 | Fenway Park (41-25) | 62-59 | |
| » Starters: Ned Garver vs Frank Sullivan | Third | 13½ out |
| » Defeated Athletics (57-66), 3-2 | Fenway Park (42-25) | 63-59 | Won 2 |
| » Starters: Ray Herbert vs Ted Bowsfield | Third | 13½ out |
| Wednesday, August 27 |
| » Defeated Tigers (59-64), 3-2 | Fenway Park (43-25) | 64-59 | Won 3 |
| » Starters: Jim Bunning vs Tom Brewer | Third | 13½ out |
| » Lost to Tigers (60-64), 7-2 | Fenway Park (43-26) | 64-60 | |
| » Starters: Paul Foytack vs Ike Delock | Third | 13½ out |
| Thursday, August 28 |
| Former Red Sox Jean Dubuc dies in Fort Myers, FL at the age of 70. |
| Friday, August 29 |
| » Defeated Orioles (61-64), 5-2 | Fenway Park (44-26) | 65-60 | |
| » Starters: Arnie Portocarrero vs Frank Sullivan | Third | 12½ out |
| Saturday, August 30 |
| » Lost to Orioles (62-64), 7-2 | Fenway Park (44-27) | 65-61 | |
| » Starters: Milt Pappas vs Bill Monbouquette | Third | 12½ out |
| Sunday, August 31 |
| » Defeated Orioles (62-65), 3-2 | Fenway Park (45-27) | 66-61 | |
| » Starters: Hoyt Wilhelm vs Tom Brewer | Third | 12½ out |
| Monday, September 1 |
| » Defeated Yankees (80-51), 4-2 | Yankee Stadium (4-4) | 67-61 | Won 2 |
| » Starters: Ted Bowsfield vs Bobby Shantz | Third | 12½ out |
| » Lost to Yankees (81-51), 4-2 | Yankee Stadium (4-5) | 67-62 | |
| » Starters: Ike Delock vs Duke Maas | Third | 12½ out |
| Tuesday, September 2 |
| » Lost to Yankees (82-51), 6-1 | Yankee Stadium (4-6) | 67-63 | Lost 2 |
| » Starters: Dave Sisler vs Zach Monroe | Third | 13½ out |
| Wednesday, September 3 |
| » Lost to Yankees (83-51), 8-5 | Yankee Stadium (4-7) | 67-64 | Lost 3 |
| » Starters: Frank Sullivan vs Murry Dickson | Third | 14½ out |
| Thursday, September 4 |
| » Defeated Orioles (65-67), 5-2 | Memorial Stadium (3-5) | 68-64 | |
| » Starters: Bill Monbouquette vs Milt Pappas | Third | 14 out |
| Friday, September 5 |
| » Defeated Orioles (65-68), 10-2 | Memorial Stadium (4-5) | 69-64 | Won 2 |
| » Starters: Tom Brewer vs Jack Harshman | Third | 13 out |
| Saturday, September 6 |
| » Lost to Orioles (66-68), 4-2 | Memorial Stadium (4-6) | 69-65 | |
| » Starters: Ike Delock vs Billy O'Dell | Third | 13 out |
| Sunday, September 7 |
| » Defeated Orioles (66-69), 6-5 | Memorial Stadium (5-6) | 70-65 | |
| » Starters: Ted Bowsfield vs Hal Brown | Third | 12½ out |
| Tuesday, September 9 |
| » Lost to White Sox (72-65), 4-1 | Comiskey Park I (3-6) | 70-66 | |
| » Starters: Frank Sullivan vs Early Wynn | Third | 12½ out |
| » Major-league debuts: Johnny Callison (White Sox) |
| Wednesday, September 10 |
| » Lost to White Sox (73-65), 7-2 | Comiskey Park I (3-7) | 70-67 | Lost 2 |
| » Starters: Tom Brewer vs Billy Pierce | Third | 13½ out |
| Thursday, September 11 |
| » Lost to White Sox (74-65), 4-1 | Comiskey Park I (3-8) | 70-68 | Lost 3 |
| » Starters: Ike Delock vs Dick Donovan | Third | 14 out |
| Friday, September 12 |
| » Lost to Indians (68-72), 5-4 | Cleveland Stadium (5-5) | 70-69 | Lost 4 |
| » Starters: Ted Bowsfield vs Gary Bell | Third | 15 out |
| Saturday, September 13 |
| » Lost to Indians (69-72), 4-1 | Cleveland Stadium (5-6) | 70-70 | Lost 5 |
| » Starters: Dave Sisler vs Cal McLish | Third | 16 out |
| Sunday, September 14 |
| » Lost to Tigers (70-71), 6-1 | Tiger Stadium (3-7) | 70-71 | Lost 6 |
| » Starters: Frank Sullivan vs Paul Foytack | Fourth | 18 out |
| » Lost to Tigers (71-71), 9-3 | Tiger Stadium (3-8) | 70-72 | Lost 7 |
| » Starters: Tom Brewer vs Billy Hoeft | Fourth | 18 out |
| » Major-league debuts: Jerry Casale (Red Sox) |
| Tuesday, September 16 |
| » Major-league debuts: Bob Allison (Senators) |
| Wednesday, September 17 |
| » Lost to Athletics (68-76), 6-3 | Municipal Stadium (3-6) | 70-73 | Lost 8 |
| » Starters: Ike Delock vs Ray Herbert | Fourth | 17 out |
| » Defeated Athletics (68-77), 4-2 | Municipal Stadium (4-6) | 71-73 | |
| » Starters: Bill Monbouquette vs Ned Garver | Fourth | 17 out |
| Thursday, September 18 |
| » Lost to Athletics (69-77), 4-1 | Municipal Stadium (4-7) | 71-74 | |
| » Starters: Ted Bowsfield vs Bud Daley | Fifth | 17½ out |
| Friday, September 19 |
| » Defeated Senators (61-84), 2-0 | Fenway Park (46-27) | 72-74 | |
| » Starters: Camilo Pascual vs Tom Brewer | Fifth | 16½ out |
| Saturday, September 20 |
| » Defeated Senators (61-85), 2-0 | Fenway Park (47-27) | 73-74 | Won 2 |
| » Starters: Vito Valentinetti vs Frank Sullivan | Fourth | 15½ out |
| Sunday, September 21 |
| » Defeated Senators (61-86), 2-0 | Fenway Park (48-27) | 74-74 | Won 3 |
| » Starters: Bill Fischer vs Ike Delock | Third | 14½ out |
| Monday, September 22 |
| Future Red Sox Dave Sax is born in Sacramento, CA. |
| Tuesday, September 23 |
| » Defeated Yankees (89-61), 9-8 | Fenway Park (49-27) | 75-74 | Won 4 |
| » Starters: Bob Turley vs Ted Bowsfield | Third | 13½ out |
| Wednesday, September 24 |
| » Lost to Yankees (90-61), 7-5 | Fenway Park (49-28) | 75-75 | |
| » Starters: Duke Maas vs Tom Brewer | Third | 14½ out |
| Friday, September 26 |
| » Defeated Senators (61-90), 6-4 | Griffith Stadium (3-5) | 76-75 | |
| » Starters: Ike Delock vs Vito Valentinetti | Third | 13 out |
| » Defeated Senators (61-91), 3-1 | Griffith Stadium (4-5) | 77-75 | Won 2 |
| » Starters: Frank Sullivan vs Bill Fischer | Third | 13 out |
| Saturday, September 27 |
| » Defeated Senators (61-92), 9-5 | Griffith Stadium (5-5) | 78-75 | Won 3 |
| » Starters: Dave Sisler vs Pedro Ramos | Third | 12½ out |
| Sunday, September 28 |
| » Defeated Senators (61-93), 6-4 | Griffith Stadium (6-5) | 79-75 | <