| Sunday, January 5 |
| Future Oriole Ron Kittle is born in Gary, IN. |
| Monday, January 20 |
| Future Oriole Bill Scherrer is born in Tonawanda, NY. |
| Monday, February 17 |
| Future Oriole Alan Wiggins is born in Los Angeles, CA. |
| Sunday, February 23 |
| Future Oriole John Shelby is born in Lexington, KY. |
| Monday, April 14 |
| » Major-league debuts: Albie Pearson (Senators) |
| Tuesday, April 15 |
| » Defeated Senators (1-1), 6-1 | Memorial Stadium (1-0) | 1-0 | |
| » Starters: Camilo Pascual vs Connie Johnson | First | -- |
| » Major-league debuts: Ron Hansen and Jim Marshall (Orioles) |
| Thursday, April 17 |
| » Defeated Senators (1-2), 4-0 | Memorial Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Chuck Stobbs vs Milt Pappas | First | -- |
| Friday, April 18 |
| » Lost to Yankees (3-1), 3-1 | Yankee Stadium (0-1) | 2-1 | |
| » Starters: Billy Loes vs Whitey Ford | Second | ½ out |
| Saturday, April 19 |
| » Lost to Yankees (4-1), 4-3 | Yankee Stadium (0-2) | 2-2 | Lost 2 |
| » Starters: Billy O'Dell vs Bobby Shantz | Third | 1½ out |
| Sunday, April 20 |
| » Lost to Yankees (5-1), 7-0 | Yankee Stadium (0-3) | 2-3 | Lost 3 |
| » Starters: Connie Johnson vs Bob Turley | Fourth | 2½ out |
| Tuesday, April 22 |
| » Defeated Senators (3-3), 4-2 | Griffith Stadium (1-0) | 3-3 | |
| » Starters: Jack Harshman vs Ralph Lumenti | Fourth | 3 out |
| Wednesday, April 23 |
| » Lost to Red Sox (2-7), 7-5 | Fenway Park (0-1) | 3-4 | |
| » Starters: Hal Brown vs Tom Brewer | Sixth | 3 out |
| Thursday, April 24 |
| » Lost to Red Sox (3-7), 4-3 | Fenway Park (0-2) | 3-5 | Lost 2 |
| » Starters: Milt Pappas vs Mike Fornieles | Sixth | 3½ out |
| Friday, April 25 |
| » Defeated Yankees (7-3), 2-1 | Memorial Stadium (3-0) | 4-5 | |
| » Starters: Whitey Ford vs Connie Johnson | Fifth | 2½ out |
| Saturday, April 26 |
| » Lost to Yankees (8-3), 2-0 | Memorial Stadium (3-1) | 4-6 | |
| » Starters: Bob Turley vs Billy Loes | Sixth | 3½ out |
| Wednesday, April 30 |
| » Defeated White Sox (3-9), 3-2 | Memorial Stadium (4-1) | 5-6 | |
| » Starters: Early Wynn vs Jack Harshman | Sixth | 3 out |
| Thursday, May 1 |
| » Lost to White Sox (4-9), 4-3 | Memorial Stadium (4-2) | 5-7 | |
| » Starters: Jim Wilson vs Connie Johnson | Fifth | 3½ out |
| Friday, May 2 |
| » Lost to Indians (9-7), 6-1 | Memorial Stadium (4-3) | 5-8 | Lost 2 |
| » Starters: Mudcat Grant vs Billy Loes | Sixth | 4½ out |
| Saturday, May 3 |
| » Defeated Indians (9-8), 3-2 | Memorial Stadium (5-3) | 6-8 | |
| » Starters: Cal McLish vs Billy O'Dell | Sixth | 4 out |
| Sunday, May 4 |
| » Defeated Tigers (8-9), 4-3 | Memorial Stadium (6-3) | 7-8 | Won 2 |
| » Starters: Paul Foytack vs Milt Pappas | Fifth | 3 out |
| » Defeated Tigers (8-10), 4-0 | Memorial Stadium (7-3) | 8-8 | Won 3 |
| » Starters: Billy Hoeft vs Jack Harshman | Fifth | 3 out |
| Friday, May 9 |
| » Lost to Red Sox (10-11), 13-5 | Memorial Stadium (7-4) | 8-9 | |
| » Starters: Dave Sisler vs Billy O'Dell | Fifth | 4 out |
| Saturday, May 10 |
| » Defeated Red Sox (10-12), 5-2 | Memorial Stadium (8-4) | 9-9 | |
| » Starters: Tom Brewer vs Jack Harshman | Third | 4 out |
| Sunday, May 11 |
| » Defeated Red Sox (10-13), 3-2 | Memorial Stadium (9-4) | 10-9 | Won 2 |
| » Starters: Frank Baumann vs Billy Loes | Third | 3 out |
| » Defeated Red Sox (10-14), 4-0 | Memorial Stadium (10-4) | 11-9 | Won 3 |
| » Starters: Willard Nixon vs Arnie Portocarrero | Third | 3 out |
| Future Oriole Mark Huismann is born in Littleton, CO. |
| Tuesday, May 13 |
| » Lost to Yankees (14-5), 3-0 | Yankee Stadium (0-4) | 11-10 | |
| » Starters: Connie Johnson vs Don Larsen | Third | 4 out |
| Wednesday, May 14 |
| » Lost to Yankees (15-5), 1-0 | Yankee Stadium (0-5) | 11-11 | Lost 2 |
| » Starters: Billy O'Dell vs Bob Turley | Third | 5 out |
| Saturday, May 17 |
| » Lost to Red Sox (13-15), 7-4 | Fenway Park (0-3) | 11-12 | Lost 3 |
| » Starters: Jack Harshman vs Tom Brewer | Second | 6 out |
| » Defeated Red Sox (13-16), 5-3 | Fenway Park (1-3) | 12-12 | |
| » Starters: Arnie Portocarrero vs Frank Baumann | Second | 6 out |
| Sunday, May 18 |
| » Lost to Red Sox (14-16), 8-4 | Fenway Park (1-4) | 12-13 | |
| » Starters: Billy Loes vs Frank Sullivan | Fourth | 7½ out |
| Monday, May 19 |
| Future Oriole Fritzie Connally is born in Bryan, TX. |
| Tuesday, May 20 |
| » Defeated Tigers (13-18), 6-4 | Tiger Stadium (1-0) | 13-13 | |
| » Starters: Billy O'Dell vs Billy Hoeft | Third | 7½ out |
| Wednesday, May 21 |
| » Defeated Tigers (13-19), 8-1 | Tiger Stadium (2-0) | 14-13 | Won 2 |
| » Starters: Connie Johnson vs Frank Lary | Second | 7½ out |
| Thursday, May 22 |
| » Lost to White Sox (12-18), 5-1 | Comiskey Park I (0-1) | 14-14 | |
| » Starters: Arnie Portocarrero vs Jim Wilson | Second | 8½ out |
| Friday, May 23 |
| » Lost to White Sox (13-18), 1-0 | Comiskey Park I (0-2) | 14-15 | Lost 2 |
| » Starters: Jack Harshman vs Early Wynn | Fourth | 9½ out |
| Saturday, May 24 |
| » Lost to White Sox (14-18), 4-3 | Comiskey Park I (0-3) | 14-16 | Lost 3 |
| » Starters: Billy O'Dell vs Bob Keegan | Fourth | 9½ out |
| Sunday, May 25 |
| » Lost to Athletics (15-16), 4-0 | Municipal Stadium (0-1) | 14-17 | Lost 4 |
| » Starters: Milt Pappas vs Ned Garver | Fifth | 11 out |
| Monday, May 26 |
| » Lost to Athletics (16-16), 5-4 | Municipal Stadium (0-2) | 14-18 | Lost 5 |
| » Starters: Connie Johnson vs Ralph Terry | Sixth | 11½ out |
| Tuesday, May 27 |
| » Lost to Indians (19-20), 7-6 | Cleveland Stadium (0-1) | 14-19 | Lost 6 |
| » Starters: Billy Loes vs Mudcat Grant | Seventh | 11½ out |
| Wednesday, May 28 |
| » Lost to Indians (20-20), 5-2 | Cleveland Stadium (0-2) | 14-20 | Lost 7 |
| » Starters: Jack Harshman vs Cal McLish | Seventh | 11½ out |
| Friday, May 30 |
| » Lost to Red Sox (20-20), 2-0 | Memorial Stadium (10-5) | 14-21 | Lost 8 |
| » Starters: Frank Sullivan vs Connie Johnson | Eighth | 10½ out |
| » Defeated Red Sox (20-21), 2-0 | Memorial Stadium (11-5) | 15-21 | |
| » Starters: Bob Smith vs Arnie Portocarrero | Eighth | 10½ out |
| Saturday, May 31 |
| » Defeated Senators (17-23), 4-3 | Memorial Stadium (12-5) | 16-21 | Won 2 |
| » Starters: Al Cicotte vs Billy O'Dell | Seventh | 10½ out |
| Sunday, June 1 |
| » Lost to Senators (18-23), 5-2 | Memorial Stadium (12-6) | 16-22 | |
| » Starters: Camilo Pascual vs Billy Loes | Eighth | 11½ out |
| Monday, June 2 |
| » Lost to Senators (19-23), 2-1 | Memorial Stadium (12-7) | 16-23 | Lost 2 |
| » Starters: Hal Griggs vs Jack Harshman | Seventh | 12½ out |
| Future Oriole Jack O'Connor is born in Twentynine Palms, CA. |
| Tuesday, June 3 |
| » Defeated Tigers (19-24), 2-0 | Memorial Stadium (13-7) | 17-23 | |
| » Starters: Jim Bunning vs Arnie Portocarrero | Seventh | 12½ out |
| Wednesday, June 4 |
| » Defeated Tigers (19-25), 6-4 | Memorial Stadium (14-7) | 18-23 | Won 2 |
| » Starters: Frank Lary vs Connie Johnson | Sixth | 11½ out |
| Thursday, June 5 |
| » Lost to Tigers (20-25), 6-3 | Memorial Stadium (14-8) | 18-24 | |
| » Starters: Paul Foytack vs Billy O'Dell | Eighth | 12 out |
| Friday, June 6 |
| » Defeated Athletics (23-20), 2-1 | Memorial Stadium (15-8) | 19-24 | |
| » Starters: Alex Kellner vs Connie Johnson | Seventh | 11½ out |
| » Defeated Athletics (23-21), 3-1 | Memorial Stadium (16-8) | 20-24 | Won 2 |
| » Starters: Ray Herbert vs Milt Pappas | Seventh | 11½ out |
| Saturday, June 7 |
| » Lost to Athletics (24-21), 5-2 | Memorial Stadium (16-9) | 20-25 | |
| » Starters: Murry Dickson vs Jack Harshman | Eighth | 12½ out |
| Sunday, June 8 |
| » Defeated Athletics (24-22), 4-0 | Memorial Stadium (17-9) | 21-25 | |
| » Starters: Ned Garver vs Hal Brown | Sixth | 11½ out |
| » Lost to Athletics (25-22), 2-1 | Memorial Stadium (17-10) | 21-26 | |
| » Starters: Duke Maas vs Arnie Portocarrero | Sixth | 11½ out |
| Monday, June 9 |
| » Defeated Indians (24-28), 5-2 | Memorial Stadium (18-10) | 22-26 | |
| » Starters: Cal McLish vs Billy O'Dell | Sixth | 11 out |
| Tuesday, June 10 |
| » Lost to Indians (25-28), 10-2 | Memorial Stadium (18-11) | 22-27 | |
| » Starters: Gary Bell vs Connie Johnson | Sixth | 11½ out |
| Wednesday, June 11 |
| » Defeated Indians (25-29), 7-4 | Memorial Stadium (19-11) | 23-27 | |
| » Starters: Dick Tomanek vs Milt Pappas | Sixth | 12 out |
| Thursday, June 12 |
| » Defeated Indians (25-30), 7-5 | Memorial Stadium (20-11) | 24-27 | Won 2 |
| » Starters: Mudcat Grant vs Arnie Portocarrero | Fifth | 11½ out |
| Friday, June 13 |
| » Tied White Sox, 5-5 | Memorial Stadium (20-11) | 24-27 | |
| » Starters: Billy Pierce vs Jack Harshman | Fifth | 11 out |
| Saturday, June 14 |
| » Lost to White Sox (23-30), 9-1 | Memorial Stadium (20-12) | 24-28 | |
| » Starters: Early Wynn vs Billy Loes | Seventh | 11 out |
| Sunday, June 15 |
| » Lost to White Sox (24-30), 3-0 | Memorial Stadium (20-13) | 24-29 | Lost 2 |
| » Starters: Jim Wilson vs Ken Lehman | Eighth | 11 out |
| » Lost to White Sox (25-30), 4-0 | Memorial Stadium (20-14) | 24-30 | Lost 3 |
| » Starters: Dick Donovan vs Arnie Portocarrero | Eighth | 11 out |
| Tuesday, June 17 |
| » Defeated Athletics (28-28), 4-1 | Municipal Stadium (1-2) | 25-30 | |
| » Starters: Billy O'Dell vs Ray Herbert | Seventh | 11 out |
| Wednesday, June 18 |
| » Defeated Athletics (28-29), 5-3 | Municipal Stadium (2-2) | 26-30 | Won 2 |
| » Starters: Milt Pappas vs Murry Dickson | Fifth | 11 out |
| Thursday, June 19 |
| » Defeated Athletics (28-30), 4-2 | Municipal Stadium (3-2) | 27-30 | Won 3 |
| » Starters: Hal Brown vs Ned Garver | Fourth | 11 out |
| Friday, June 20 |
| » Lost to White Sox (28-31), 5-3 | Comiskey Park I (0-4) | 27-31 | |
| » Starters: Jack Harshman vs Dick Donovan | Sixth | 11 out |
| Future Oriole Phil Huffman is born in Freeport, TX. |
| Saturday, June 21 |
| » Lost to White Sox (29-31), 1-0 | Comiskey Park I (0-5) | 27-32 | Lost 2 |
| » Starters: Billy Loes vs Billy Pierce | Seventh | 11 out |
| Sunday, June 22 |
| » Defeated White Sox (29-32), 2-0 | Comiskey Park I (1-5) | 28-32 | |
| » Starters: Billy O'Dell vs Jim Wilson | Seventh | 11 out |
| Monday, June 23 |
| » Lost to Tigers (31-31), 3-1 | Tiger Stadium (2-1) | 28-33 | |
| » Starters: Arnie Portocarrero vs George Susce | Seventh | 11 out |
| Tuesday, June 24 |
| » Lost to Tigers (32-31), 5-0 | Tiger Stadium (2-2) | 28-34 | Lost 2 |
| » Starters: Milt Pappas vs Paul Foytack | Seventh | 12 out |
| Thursday, June 26 |
| » Defeated Tigers (32-32), 2-0 | Tiger Stadium (3-2) | 29-34 | |
| » Starters: Jack Harshman vs Billy Hoeft | Seventh | 12 out |
| Friday, June 27 |
| » Lost to Indians (32-36), 6-5 | Cleveland Stadium (0-3) | 29-35 | |
| » Starters: Billy O'Dell vs Ray Narleski | Seventh | 13 out |
| Saturday, June 28 |
| » Lost to Indians (33-36), 6-5 | Cleveland Stadium (0-4) | 29-36 | Lost 2 |
| » Starters: Billy Loes vs Mudcat Grant | Seventh | 14 out |
| Sunday, June 29 |
| » Defeated Indians (33-37), 11-6 | Cleveland Stadium (1-4) | 30-36 | |
| » Starters: Milt Pappas vs Gary Bell | Seventh | 12½ out |
| » Defeated Indians (33-38), 5-2 | Cleveland Stadium (2-4) | 31-36 | Won 2 |
| » Starters: Arnie Portocarrero vs Jim Constable | Seventh | 12½ out |
| Tuesday, July 1 |
| » Defeated Yankees (43-24), 7-5 | Memorial Stadium (21-14) | 32-36 | Won 3 |
| » Starters: Johnny Kucks vs Hal Brown | Seventh | 12½ out |
| » Lost to Yankees (44-24), 2-1 | Memorial Stadium (21-15) | 32-37 | |
| » Starters: Don Larsen vs Jack Harshman | Seventh | 12½ out |
| Wednesday, July 2 |
| » Lost to Yankees (45-24), 4-1 | Memorial Stadium (21-16) | 32-38 | Lost 2 |
| » Starters: Zach Monroe vs Billy O'Dell | Seventh | 13½ out |
| Thursday, July 3 |
| » Defeated Red Sox (36-36), 7-5 | Fenway Park (2-4) | 33-38 | |
| » Starters: Charlie Beamon vs Duane Wilson | Seventh | 13½ out |
| Friday, July 4 |
| » Lost to Red Sox (37-36), 5-1 | Fenway Park (2-5) | 33-39 | |
| » Starters: Milt Pappas vs Frank Sullivan | Seventh | 14½ out |
| » Defeated Red Sox (37-37), 5-3 | Fenway Park (3-5) | 34-39 | |
| » Starters: Arnie Portocarrero vs Mike Fornieles | Seventh | 14½ out |
| Saturday, July 5 |
| » Defeated Senators (30-45), 3-1 | Griffith Stadium (2-0) | 35-39 | Won 2 |
| » Starters: Hal Brown vs Hal Griggs | Seventh | 14 out |
| Sunday, July 6 |
| » Lost to Senators (31-45), 4-3 | Griffith Stadium (2-1) | 35-40 | |
| » Starters: Jack Harshman vs Russ Kemmerer | Sixth | 14 out |
| Thursday, July 10 |
| » Defeated Athletics (38-38), 6-3 | Memorial Stadium (22-16) | 36-40 | |
| » Starters: Bud Daley vs Milt Pappas | Fifth | 13½ out |
| » Defeated Athletics (38-39), 3-2 | Memorial Stadium (23-16) | 37-40 | Won 2 |
| » Starters: Ray Herbert vs Arnie Portocarrero | Fifth | 13½ out |
| Sunday, July 13 |
| » Lost to Tigers (39-39), 6-5 | Memorial Stadium (23-17) | 37-41 | |
| » Starters: Paul Foytack vs Charlie Beamon | Seventh | 15½ out |
| » Lost to Tigers (40-39), 5-3 | Memorial Stadium (23-18) | 37-42 | Lost 2 |
| » Starters: George Susce vs Billy O'Dell | Seventh | 15½ out |
| Monday, July 14 |
| » Defeated Tigers (40-40), 2-1 | Memorial Stadium (24-18) | 38-42 | |
| » Starters: Herb Moford vs Hal Brown | Sixth | 15½ out |
| Tuesday, July 15 |
| » Defeated White Sox (39-44), 4-3 | Memorial Stadium (25-18) | 39-42 | Won 2 |
| » Starters: Jim Wilson vs Arnie Portocarrero | Fourth | 14½ out |
| Wednesday, July 16 |
| » Lost to White Sox (40-44), 6-1 | Memorial Stadium (25-19) | 39-43 | |
| » Starters: Dick Donovan vs Milt Pappas | Fourth | 15 out |
| » Defeated White Sox (40-45), 6-5 | Memorial Stadium (26-19) | 40-43 | |
| » Starters: Bob Shaw vs Jack Harshman | Fourth | 15 out |
| Thursday, July 17 |
| » Defeated White Sox (40-46), 3-0 | Memorial Stadium (27-19) | 41-43 | Won 2 |
| » Starters: Billy Pierce vs Billy O'Dell | Fourth | 15 out |
| Friday, July 18 |
| » Lost to Indians (41-47), 5-1 | Memorial Stadium (27-20) | 41-44 | |
| » Starters: Hal Woodeshick vs Charlie Beamon | Fourth | 15 out |
| Saturday, July 19 |
| » Defeated Indians (41-48), 3-2 | Memorial Stadium (28-20) | 42-44 | |
| » Starters: Gary Bell vs Hal Brown | Third | 14 out |
| Sunday, July 20 |
| » Defeated Indians (41-49), 3-2 | Memorial Stadium (29-20) | 43-44 | Won 2 |
| » Starters: Hoyt Wilhelm vs Arnie Portocarrero | Third | 14½ out |
| Tuesday, July 22 |
| » Lost to White Sox (44-47), 4-2 | Comiskey Park I (1-6) | 43-45 | |
| » Starters: Jack Harshman vs Billy Pierce | Third | 15½ out |
| Wednesday, July 23 |
| » Defeated White Sox (44-48), 6-4 | Comiskey Park I (2-6) | 44-45 | |
| » Starters: Billy O'Dell vs Early Wynn | Third | 15½ out |
| Thursday, July 24 |
| » Defeated White Sox (44-49), 7-3 | Comiskey Park I (3-6) | 45-45 | Won 2 |
| » Starters: Milt Pappas vs Jim Wilson | Third | 15½ out |
| Friday, July 25 |
| » Defeated Athletics (43-47), 8-3 | Municipal Stadium (4-2) | 46-45 | Won 3 |
| » Starters: Arnie Portocarrero vs Bob Grim | Third | 15½ out |
| Saturday, July 26 |
| » Defeated Athletics (43-48), 4-3 | Municipal Stadium (5-2) | 47-45 | Won 4 |
| » Starters: Jack Harshman vs Bob Davis | Second | 15½ out |
| » Major-league debuts: Bob Davis (Athletics) |
| Sunday, July 27 |
| » Lost to Athletics (44-48), 11-6 | Municipal Stadium (5-3) | 47-46 | |
| » Starters: Hal Brown vs Ned Garver | Third | 15 out |
| Tuesday, July 29 |
| » Lost to Indians (47-52), 9-4 | Cleveland Stadium (2-5) | 47-47 | Lost 2 |
| » Starters: Milt Pappas vs Gary Bell | Third | 15½ out |
| Wednesday, July 30 |
| » Lost to Indians (48-52), 6-3 | Cleveland Stadium (2-6) | 47-48 | Lost 3 |
| » Starters: Arnie Portocarrero vs Ray Narleski | Third | 15½ out |
| Friday, August 1 |
| » Lost to Tigers (47-52), 3-1 | Tiger Stadium (3-3) | 47-49 | Lost 4 |
| » Starters: Jack Harshman vs Herb Moford | Third | 17 out |
| Saturday, August 2 |
| » Lost to Tigers (48-52), 8-7 | Tiger Stadium (3-4) | 47-50 | Lost 5 |
| » Starters: Billy O'Dell vs Jim Bunning | Fourth | 18 out |
| Sunday, August 3 |
| » Lost to Tigers (49-52), 3-2 | Tiger Stadium (3-5) | 47-51 | Lost 6 |
| » Starters: Milt Pappas vs Paul Foytack | Sixth | 18 out |
| » Lost to Tigers (50-52), 4-1 | Tiger Stadium (3-6) | 47-52 | Lost 7 |
| » Starters: Hal Brown vs Billy Hoeft | Sixth | 18 out |
| Monday, August 4 |
| » Lost to Yankees (68-36), 9-4 | Memorial Stadium (29-21) | 47-53 | Lost 8 |
| » Starters: Don Larsen vs Arnie Portocarrero | Sixth | 19 out |
| Tuesday, August 5 |
| » Lost to Yankees (69-36), 4-1 | Memorial Stadium (29-22) | 47-54 | Lost 9 |
| » Starters: Bob Turley vs Connie Johnson | Sixth | 20 out |
| Wednesday, August 6 |
| » Lost to Yankees (70-36), 3-1 | Memorial Stadium (29-23) | 47-55 | Lost 10 |
| » Starters: Art Ditmar vs Jack Harshman | Sixth | 21 out |
| Friday, August 8 |
| » Lost to Senators (46-62), 4-2 | Griffith Stadium (2-2) | 47-56 | Lost 11 |
| » Starters: Hal Brown vs Russ Kemmerer | Sixth | 22 out |
| Saturday, August 9 |
| » Defeated Senators (46-63), 12-5 | Griffith Stadium (3-2) | 48-56 | |
| » Starters: Arnie Portocarrero vs Camilo Pascual | Sixth | 21 out |
| Sunday, August 10 |
| » Lost to Senators (47-63), 6-2 | Griffith Stadium (3-3) | 48-57 | |
| » Starters: Milt Pappas vs Pedro Ramos | Sixth | 21 out |
| » Defeated Senators (47-64), 6-1 | Griffith Stadium (4-3) | 49-57 | |
| » Starters: Billy O'Dell vs Hal Griggs | Sixth | 21 out |
| Monday, August 11 |
| » Defeated Yankees (72-39), 3-2 | Yankee Stadium (1-5) | 50-57 | Won 2 |
| » Starters: Jack Harshman vs Art Ditmar | Fifth | 19 out |
| » Defeated Yankees (72-40), 9-3 | Yankee Stadium (2-5) | 51-57 | Won 3 |
| » Starters: Connie Johnson vs Johnny Kucks | Fifth | 19 out |
| Tuesday, August 12 |
| » Lost to Yankees (73-40), 7-2 | Yankee Stadium (2-6) | 51-58 | |
| » Starters: Hal Brown vs Tom Sturdivant | Sixth | 20 out |
| Wednesday, August 13 |
| » Defeated Red Sox (56-55), 2-1 | Memorial Stadium (30-23) | 52-58 | |
| » Starters: Frank Sullivan vs Arnie Portocarrero | Fifth | 19 out |
| Friday, August 15 |
| » Lost to Senators (50-64), 3-1 | Memorial Stadium (30-24) | 52-59 | |
| » Starters: Vito Valentinetti vs Jack Harshman | Sixth | 19½ out |
| Saturday, August 16 |
| » Defeated Senators (50-65), 9-0 | Memorial Stadium (31-24) | 53-59 | |
| » Starters: Pedro Ramos vs Billy O'Dell | Sixth | 18½ out |
| Sunday, August 17 |
| » Defeated Senators (50-66), 2-1 | Memorial Stadium (32-24) | 54-59 | Won 2 |
| » Starters: Russ Kemmerer vs Connie Johnson | Fifth | 17½ out |
| Monday, August 18 |
| » Defeated Athletics (52-63), 8-2 | Memorial Stadium (33-24) | 55-59 | Won 3 |
| » Starters: Ralph Terry vs Hal Brown | Fifth | 17 out |
| Tuesday, August 19 |
| » Lost to Athletics (53-63), 4-1 | Memorial Stadium (33-25) | 55-60 | |
| » Starters: Ned Garver vs Milt Pappas | Sixth | 17½ out |
| » Lost to Athletics (54-63), 6-4 | Memorial Stadium (33-26) | 55-61 | Lost 2 |
| » Starters: Murry Dickson vs Arnie Portocarrero | Sixth | 17½ out |
| Future Oriole Luis DeLeon is born in Ponce, P.R. |
| Wednesday, August 20 |
| » Defeated Athletics (54-64), 4-3 | Memorial Stadium (34-26) | 56-61 | |
| » Starters: Walt Craddock vs Jack Harshman | Fifth | 17½ out |
| Thursday, August 21 |
| » Defeated Tigers (57-61), 7-6 | Memorial Stadium (35-26) | 57-61 | Won 2 |
| » Starters: Billy Hoeft vs Billy O'Dell | Fourth | 17½ out |
| Friday, August 22 |
| » Defeated Tigers (57-62), 2-1 | Memorial Stadium (36-26) | 58-61 | Won 3 |
| » Starters: Jim Bunning vs Connie Johnson | Fourth | 17½ out |
| Saturday, August 23 |
| » Lost to Tigers (58-62), 5-1 | Memorial Stadium (36-27) | 58-62 | |
| » Starters: Paul Foytack vs Arnie Portocarrero | Fourth | 17½ out |
| Sunday, August 24 |
| » Defeated White Sox (65-58), 5-2 | Memorial Stadium (37-27) | 59-62 | |
| » Starters: Dick Donovan vs Billy O'Dell | Fourth | 17 out |
| Monday, August 25 |
| » Defeated White Sox (65-59), 6-5 | Memorial Stadium (38-27) | 60-62 | Won 2 |
| » Starters: Ray Moore vs Jack Harshman | Fourth | 16½ out |
| Tuesday, August 26 |
| » Defeated Indians (59-67), 1-0 | Memorial Stadium (39-27) | 61-62 | Won 3 |
| » Starters: Don Ferrarese vs Hal Brown | Fourth | 16½ out |
| Wednesday, August 27 |
| » Lost to Indians (60-67), 8-5 | Memorial Stadium (39-28) | 61-63 | |
| » Starters: Cal McLish vs Connie Johnson | Fourth | 16½ out |
| Friday, August 29 |
| » Lost to Red Sox (65-60), 5-2 | Fenway Park (3-6) | 61-64 | Lost 2 |
| » Starters: Arnie Portocarrero vs Frank Sullivan | Fourth | 16½ out |
| Saturday, August 30 |
| » Defeated Red Sox (65-61), 7-2 | Fenway Park (4-6) | 62-64 | |
| » Starters: Milt Pappas vs Bill Monbouquette | Fourth | 15½ out |
| Sunday, August 31 |
| » Lost to Red Sox (66-61), 3-2 | Fenway Park (4-7) | 62-65 | |
| » Starters: Hoyt Wilhelm vs Tom Brewer | Fourth | 16½ out |
| Monday, September 1 |
| » Defeated Senators (54-75), 2-0 | Griffith Stadium (5-3) | 63-65 | |
| » Starters: Jack Harshman vs Camilo Pascual | Fourth | 15½ out |
| » Defeated Senators (54-76), 10-1 | Griffith Stadium (6-3) | 64-65 | Won 2 |
| » Starters: Billy O'Dell vs Jim Constable | Fourth | 15½ out |
| Tuesday, September 2 |
| » Lost to Senators (55-76), 4-3 | Griffith Stadium (6-4) | 64-66 | |
| » Starters: Hal Brown vs Pedro Ramos | Fourth | 16½ out |
| » Major-league debuts: Jerry Adair (Orioles) |
| Wednesday, September 3 |
| » Defeated Senators (55-77), 4-3 | Griffith Stadium (7-4) | 65-66 | |
| » Starters: Arnie Portocarrero vs Vito Valentinetti | Fourth | 16½ out |
| Thursday, September 4 |
| » Lost to Red Sox (68-64), 5-2 | Memorial Stadium (39-29) | 65-67 | |
| » Starters: Bill Monbouquette vs Milt Pappas | Fourth | 17 out |
| Friday, September 5 |
| » Lost to Red Sox (69-64), 10-2 | Memorial Stadium (39-30) | 65-68 | Lost 2 |
| » Starters: Tom Brewer vs Jack Harshman | Fifth | 17 out |
| Saturday, September 6 |
| » Defeated Red Sox (69-65), 4-2 | Memorial Stadium (40-30) | 66-68 | |
| » Starters: Ike Delock vs Billy O'Dell | Fourth | 16 out |
| Sunday, September 7 |
| » Lost to Red Sox (70-65), 6-5 | Memorial Stadium (40-31) | 66-69 | |
| » Starters: Ted Bowsfield vs Hal Brown | Fourth | 16½ out |
| Tuesday, September 9 |
| » Lost to Athletics (64-73), 8-6 | Municipal Stadium (5-4) | 66-70 | Lost 2 |
| » Starters: Arnie Portocarrero vs Ralph Terry | Sixth | 16½ out |
| » Major-league debuts: Willie Tasby (Orioles) |
| Wednesday, September 10 |
| » Lost to Athletics (65-73), 4-2 | Municipal Stadium (5-5) | 66-71 | Lost 3 |
| » Starters: Jack Harshman vs Bob Grim | Fifth | 17½ out |
| Thursday, September 11 |
| » Lost to Athletics (66-73), 7-1 | Municipal Stadium (5-6) | 66-72 | Lost 4 |
| » Starters: Billy O'Dell vs Ned Garver | Sixth | 18 out |
| Friday, September 12 |
| » Lost to Tigers (68-71), 3-1 | Tiger Stadium (3-7) | 66-73 | Lost 5 |
| » Starters: Hoyt Wilhelm vs Frank Lary | Seventh | 19 out |
| Saturday, September 13 |
| » Lost to Tigers (69-71), 13-2 | Tiger Stadium (3-8) | 66-74 | Lost 6 |
| » Starters: Hal Brown vs Jim Bunning | Seventh | 20 out |
| Sunday, September 14 |
| » Lost to Indians (70-72), 7-4 | Cleveland Stadium (2-7) | 66-75 | Lost 7 |
| » Starters: Connie Johnson vs Don Ferrarese | Sixth | 21 out |
| » Defeated Indians (70-73), 4-2 | Cleveland Stadium (3-7) | 67-75 | |
| » Starters: Arnie Portocarrero vs Mudcat Grant | Sixth | 21 out |
| Tuesday, September 16 |
| » Lost to White Sox (77-67), 4-3 | Comiskey Park I (3-7) | 67-76 | |
| » Starters: Billy O'Dell vs Dick Donovan | Sixth | 21 out |
| Thursday, September 18 |
| » Lost to White Sox (78-67), 6-2 | Comiskey Park I (3-8) | 67-77 | Lost 2 |
| » Starters: Jack Harshman vs Ray Moore | Seventh | 21 out |
| Friday, September 19 |
| » Defeated Yankees (89-58), 5-4 | Memorial Stadium (41-31) | 68-77 | |
| » Starters: Whitey Ford vs Arnie Portocarrero | Seventh | 20 out |
| Saturday, September 20 |
| » Defeated Yankees (89-59), 1-0 | Memorial Stadium (42-31) | 69-77 | Won 2 |
| » Starters: Don Larsen vs Hoyt Wilhelm | Sixth | 19 out |
| Sunday, September 21 |
| » Defeated Yankees (89-60), 3-2 | Memorial Stadium (43-31) | 70-77 | Won 3 |
| » Starters: Tom Sturdivant vs Milt Pappas | Fifth | 18 out |
| Monday, September 22 |
| » Defeated Senators (61-87), 2-0 | Memorial Stadium (44-31) | 71-77 | Won 4 |
| » Starters: Russ Kemmerer vs Hal Brown | Fourth | 17½ out |
| Tuesday, September 23 |
| » Defeated Senators (61-88), 3-2 | Memorial Stadium (45-31) | 72-77 | Won 5 |
| » Starters: Pedro Ramos vs Jack Harshman | Fourth | 16½ out |
| Wednesday, September 24 |
| » Defeated Senators (61-89), 2-0 | Memorial Stadium (46-31) | 73-77 | Won 6 |
| » Starters: Camilo Pascual vs Arnie Portocarrero | Fourth | 16½ out |
| Friday, September 26 |
| » Defeated Yankees (90-62), 3-2 | Yankee Stadium (3-6) | 74-77 | Won 7 |
| » Starters: Hoyt Wilhelm vs Whitey Ford | Sixth | 15½ out |
| Sunday, September 28 |
| » Lost to Yankees (91-62), 7-0 | Yankee Stadium (3-7) | 74-78 | |
| » Starters: Jack Harshman vs Don Larsen | Sixth | 17½ out |
| » Lost to Yankees (92-62), 6-3 | Yankee Stadium (3-8) | 74-79 | Lost 2 |
| » Starters: Milt Pappas vs Tom Sturdivant | Sixth | 17½ out |
Game information provided by Retrosheet (www.retrosheet.org) |