| Sunday, January 5 |
| Future Indian Ron Kittle is born in Gary, IN. |
| Sunday, February 2 |
| Future Indian Pat Tabler is born in Hamilton, OH. |
| Sunday, February 9 |
| Future Indian Pete O'Brien is born in Santa Monica, CA. |
| Wednesday, March 26 |
| Future Indian Chris Codiroli is born in Oxnard, CA. |
| Saturday, March 29 |
| Future Indian Domingo Ramos is born in Santiago, D.R. |
| Monday, April 14 |
| » Major-league debuts: Albie Pearson (Senators) |
| Tuesday, April 15 |
| » Lost to Athletics (1-0), 5-0 | Cleveland Stadium (0-1) | 0-1 | |
| » Starters: Ned Garver vs Herb Score | Third | 1 out |
| » Major-league debuts: Gary Geiger, Carroll Hardy and Billy Moran (Indians) |
| Wednesday, April 16 |
| » Lost to Athletics (2-0), 9-4 | Cleveland Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Ralph Terry vs Ray Narleski | Fifth | 2 out |
| Thursday, April 17 |
| » Defeated Athletics (2-1), 3-2 | Cleveland Stadium (1-2) | 1-2 | |
| » Starters: Duke Maas vs Mudcat Grant | Third | 1½ out |
| » Major-league debuts: Mudcat Grant (Indians) |
| Friday, April 18 |
| » Defeated Tigers (2-2), 7-5 | Tiger Stadium (1-0) | 2-2 | Won 2 |
| » Starters: Herb Score vs Billy Hoeft | Third | 1 out |
| Saturday, April 19 |
| » Lost to Tigers (3-2), 9-1 | Tiger Stadium (1-1) | 2-3 | |
| » Starters: Don Mossi vs Paul Foytack | Fourth | 2 out |
| Sunday, April 20 |
| » Defeated Tigers (3-3), 4-2 | Tiger Stadium (2-1) | 3-3 | |
| » Starters: Ray Narleski vs Jim Bunning | Third | 2 out |
| Monday, April 21 |
| » Lost to Athletics (4-2), 9-4 | Municipal Stadium (0-1) | 3-4 | |
| » Starters: Mudcat Grant vs Ralph Terry | Fifth | 3 out |
| Tuesday, April 22 |
| » Lost to Athletics (5-2), 9-6 | Municipal Stadium (0-2) | 3-5 | Lost 2 |
| » Starters: Bob Lemon vs Ned Garver | Fifth | 4 out |
| Wednesday, April 23 |
| » Defeated White Sox (2-6), 2-0 | Cleveland Stadium (2-2) | 4-5 | |
| » Starters: Billy Pierce vs Herb Score | Fifth | 3 out |
| Thursday, April 24 |
| » Defeated White Sox (2-7), 6-4 | Cleveland Stadium (3-2) | 5-5 | Won 2 |
| » Starters: Jim Wilson vs Dick Tomanek | Fifth | 2½ out |
| Friday, April 25 |
| » Defeated Tigers (6-5), 12-2 | Cleveland Stadium (4-2) | 6-5 | Won 3 |
| » Starters: Jim Bunning vs Ray Narleski | Fourth | 1½ out |
| Saturday, April 26 |
| » Defeated Tigers (6-6), 4-1 | Cleveland Stadium (5-2) | 7-5 | Won 4 |
| » Starters: Frank Lary vs Mudcat Grant | Fourth | 1½ out |
| Sunday, April 27 |
| » Lost to Tigers (7-6), 9-5 | Cleveland Stadium (5-3) | 7-6 | |
| » Starters: Billy Hoeft vs Mike Garcia | Fourth | 2 out |
| Wednesday, April 30 |
| » Lost to Senators (7-4), 3-2 | Griffith Stadium (0-1) | 7-7 | Lost 2 |
| » Starters: Herb Score vs Pedro Ramos | Fifth | 2½ out |
| Thursday, May 1 |
| » Defeated Senators (7-5), 9-1 | Griffith Stadium (1-1) | 8-7 | |
| » Starters: Ray Narleski vs Ralph Lumenti | Fourth | 2 out |
| Friday, May 2 |
| » Defeated Orioles (5-8), 6-1 | Memorial Stadium (1-0) | 9-7 | Won 2 |
| » Starters: Mudcat Grant vs Billy Loes | Fourth | 2 out |
| Saturday, May 3 |
| » Lost to Orioles (6-8), 3-2 | Memorial Stadium (1-1) | 9-8 | |
| » Starters: Cal McLish vs Billy O'Dell | Fourth | 2½ out |
| Sunday, May 4 |
| » Defeated Red Sox (6-11), 2-1 | Fenway Park (1-0) | 10-8 | |
| » Starters: Bob Kelly vs Tom Brewer | Fourth | 2½ out |
| » Lost to Red Sox (7-11), 2-1 | Fenway Park (1-1) | 10-9 | |
| » Starters: Hoyt Wilhelm vs Frank Baumann | Fourth | 2½ out |
| Monday, May 5 |
| » Lost to Red Sox (8-11), 8-5 | Fenway Park (1-2) | 10-10 | Lost 2 |
| » Starters: Ray Narleski vs Bob Smith | Fifth | 3 out |
| Friday, May 9 |
| » Lost to White Sox (5-11), 5-0 | Comiskey Park I (0-1) | 10-11 | Lost 3 |
| » Starters: Mudcat Grant vs Early Wynn | Fourth | 4 out |
| Saturday, May 10 |
| » Lost to White Sox (6-11), 5-4 | Comiskey Park I (0-2) | 10-12 | Lost 4 |
| » Starters: Don Ferrarese vs Dick Donovan | Sixth | 5 out |
| Sunday, May 11 |
| » Defeated White Sox (6-12), 4-2 | Comiskey Park I (1-2) | 11-12 | |
| » Starters: Ray Narleski vs Billy Pierce | Fifth | 5 out |
| » Lost to White Sox (7-12), 5-2 | Comiskey Park I (1-3) | 11-13 | |
| » Starters: Bob Kelly vs Jim Wilson | Fifth | 5 out |
| Future Indian Mark Huismann is born in Littleton, CO. |
| Tuesday, May 13 |
| » Lost to Tigers (13-12), 11-1 | Tiger Stadium (2-2) | 11-14 | Lost 2 |
| » Starters: Mudcat Grant vs Frank Lary | Sixth | 6 out |
| Wednesday, May 14 |
| » Defeated Tigers (13-13), 9-8 | Tiger Stadium (3-2) | 12-14 | |
| » Starters: Hoyt Wilhelm vs Paul Foytack | Fifth | 6 out |
| Former Indian Billy Clingman dies in Cincinnati, OH at the age of 89. |
| Thursday, May 15 |
| » Defeated Tigers (13-14), 8-5 | Tiger Stadium (4-2) | 13-14 | Won 2 |
| » Starters: Ray Narleski vs Billy Hoeft | Fourth | 5½ out |
| Friday, May 16 |
| » Lost to White Sox (10-14), 6-3 | Cleveland Stadium (5-4) | 13-15 | |
| » Starters: Billy Pierce vs Don Ferrarese | Fifth | 6½ out |
| Saturday, May 17 |
| » Lost to White Sox (11-14), 3-2 | Cleveland Stadium (5-5) | 13-16 | Lost 2 |
| » Starters: Ray Moore vs Cal McLish | Fourth | 7½ out |
| Sunday, May 18 |
| » Defeated White Sox (11-15), 7-4 | Cleveland Stadium (6-5) | 14-16 | |
| » Starters: Early Wynn vs Mudcat Grant | Third | 7½ out |
| » Defeated White Sox (11-16), 10-6 | Cleveland Stadium (7-5) | 15-16 | Won 2 |
| » Starters: Bill Fischer vs Bob Kelly | Third | 7½ out |
| Tuesday, May 20 |
| » Lost to Red Sox (15-16), 6-1 | Cleveland Stadium (7-6) | 15-17 | |
| » Starters: Bob Smith vs Ray Narleski | Fifth | 8½ out |
| Wednesday, May 21 |
| » Defeated Red Sox (15-17), 3-2 | Cleveland Stadium (8-6) | 16-17 | |
| » Starters: Dave Sisler vs Dick Tomanek | Third | 8½ out |
| Thursday, May 22 |
| » Defeated Senators (14-17), 3-1 | Cleveland Stadium (9-6) | 17-17 | Won 2 |
| » Starters: Camilo Pascual vs Mudcat Grant | Third | 8½ out |
| Friday, May 23 |
| » Defeated Senators (14-18), 2-1 | Cleveland Stadium (10-6) | 18-17 | Won 3 |
| » Starters: Pedro Ramos vs Cal McLish | Second | 8½ out |
| Saturday, May 24 |
| » Lost to Senators (15-18), 6-3 | Cleveland Stadium (10-7) | 18-18 | |
| » Starters: Chuck Stobbs vs Don Mossi | Third | 8½ out |
| Sunday, May 25 |
| » Lost to Yankees (24-6), 6-1 | Cleveland Stadium (10-8) | 18-19 | Lost 2 |
| » Starters: Whitey Ford vs Ray Narleski | Fourth | 10½ out |
| » Lost to Yankees (25-6), 6-3 | Cleveland Stadium (10-9) | 18-20 | Lost 3 |
| » Starters: Johnny Kucks vs Dick Tomanek | Fourth | 10½ out |
| Tuesday, May 27 |
| » Defeated Orioles (14-19), 7-6 | Cleveland Stadium (11-9) | 19-20 | |
| » Starters: Billy Loes vs Mudcat Grant | Fourth | 9½ out |
| Wednesday, May 28 |
| » Defeated Orioles (14-20), 5-2 | Cleveland Stadium (12-9) | 20-20 | Won 2 |
| » Starters: Jack Harshman vs Cal McLish | Third | 8½ out |
| Friday, May 30 |
| » Defeated Athletics (18-17), 7-1 | Municipal Stadium (1-2) | 21-20 | Won 3 |
| » Starters: Ray Narleski vs Ralph Terry | Fourth | 7½ out |
| » Lost to Athletics (19-17), 7-6 | Municipal Stadium (1-3) | 21-21 | |
| » Starters: Dick Tomanek vs Ned Garver | Fourth | 7½ out |
| Saturday, May 31 |
| » Lost to Athletics (20-17), 5-4 | Municipal Stadium (1-4) | 21-22 | Lost 2 |
| » Starters: Mudcat Grant vs Jack Urban | Third | 8½ out |
| Sunday, June 1 |
| » Lost to Athletics (21-17), 6-2 | Municipal Stadium (1-5) | 21-23 | Lost 3 |
| » Starters: Cal McLish vs Ray Herbert | Fourth | 9½ out |
| » Major-league debuts: Gary Bell (Indians) |
| Tuesday, June 3 |
| » Lost to Red Sox (21-23), 7-3 | Fenway Park (1-3) | 21-24 | Lost 4 |
| » Starters: Mudcat Grant vs Tom Brewer | Fourth | 11 out |
| Wednesday, June 4 |
| » Defeated Red Sox (21-24), 7-5 | Fenway Park (2-3) | 22-24 | |
| » Starters: Ray Narleski vs Frank Sullivan | Third | 10 out |
| Thursday, June 5 |
| » Lost to Red Sox (22-24), 5-3 | Fenway Park (2-4) | 22-25 | |
| » Starters: Gary Bell vs Bob Smith | Fifth | 10½ out |
| Friday, June 6 |
| » Lost to Yankees (31-12), 6-5 | Yankee Stadium (0-1) | 22-26 | Lost 2 |
| » Starters: Dick Tomanek vs Bob Turley | Fifth | 11½ out |
| Saturday, June 7 |
| » Lost to Yankees (32-12), 6-3 | Yankee Stadium (0-2) | 22-27 | Lost 3 |
| » Starters: Don Mossi vs Whitey Ford | Sixth | 12½ out |
| Sunday, June 8 |
| » Defeated Yankees (32-13), 14-1 | Yankee Stadium (1-2) | 23-27 | |
| » Starters: Ray Narleski vs Johnny Kucks | Fourth | 10½ out |
| » Defeated Yankees (32-14), 5-4 | Yankee Stadium (2-2) | 24-27 | Won 2 |
| » Starters: Mudcat Grant vs Sal Maglie | Fourth | 10½ out |
| Future Indian Carmen Castillo is born in San Francisco de Macoris, D.R. |
| Monday, June 9 |
| » Lost to Orioles (22-26), 5-2 | Memorial Stadium (1-2) | 24-28 | |
| » Starters: Cal McLish vs Billy O'Dell | Fifth | 11 out |
| Tuesday, June 10 |
| » Defeated Orioles (22-27), 10-2 | Memorial Stadium (2-2) | 25-28 | |
| » Starters: Gary Bell vs Connie Johnson | Fourth | 10½ out |
| Wednesday, June 11 |
| » Lost to Orioles (23-27), 7-4 | Memorial Stadium (2-3) | 25-29 | |
| » Starters: Dick Tomanek vs Milt Pappas | Fifth | 12 out |
| Thursday, June 12 |
| » Lost to Orioles (24-27), 7-5 | Memorial Stadium (2-4) | 25-30 | Lost 2 |
| » Starters: Mudcat Grant vs Arnie Portocarrero | Sixth | 12½ out |
| Friday, June 13 |
| » Defeated Senators (26-28), 10-1 | Griffith Stadium (2-1) | 26-30 | |
| » Starters: Ray Narleski vs Chuck Stobbs | Sixth | 11½ out |
| Saturday, June 14 |
| » Defeated Senators (26-29), 10-2 | Griffith Stadium (3-1) | 27-30 | Won 2 |
| » Starters: Cal McLish vs Hal Griggs | Fourth | 10½ out |
| Sunday, June 15 |
| » Defeated Senators (26-30), 5-3 | Griffith Stadium (4-1) | 28-30 | Won 3 |
| » Starters: Gary Bell vs Russ Kemmerer | Fourth | 8½ out |
| » Defeated Senators (26-31), 4-2 | Griffith Stadium (5-1) | 29-30 | Won 4 |
| » Starters: Jim Constable vs Tex Clevenger | Fourth | 8½ out |
| Tuesday, June 17 |
| » Lost to Yankees (36-19), 4-0 | Cleveland Stadium (12-10) | 29-31 | |
| » Starters: Whitey Ford vs Ray Narleski | Fifth | 9½ out |
| Wednesday, June 18 |
| » Lost to Yankees (37-19), 3-2 | Cleveland Stadium (12-11) | 29-32 | Lost 2 |
| » Starters: Art Ditmar vs Mudcat Grant | Fourth | 10½ out |
| Thursday, June 19 |
| » Lost to Yankees (38-19), 9-3 | Cleveland Stadium (12-12) | 29-33 | Lost 3 |
| » Starters: Johnny Kucks vs Gary Bell | Fifth | 11½ out |
| Saturday, June 21 |
| » Lost to Senators (28-32), 11-7 | Cleveland Stadium (12-13) | 29-34 | Lost 4 |
| » Starters: Pedro Ramos vs Cal McLish | Sixth | 11 out |
| Sunday, June 22 |
| » Defeated Senators (28-33), 4-3 | Cleveland Stadium (13-13) | 30-34 | |
| » Starters: Chuck Stobbs vs Ray Narleski | Fifth | 10½ out |
| » Defeated Senators (28-34), 1-0 | Cleveland Stadium (14-13) | 31-34 | Won 2 |
| » Starters: Hal Griggs vs Mudcat Grant | Fifth | 10½ out |
| Tuesday, June 24 |
| » Lost to Red Sox (32-33), 4-3 | Cleveland Stadium (14-14) | 31-35 | |
| » Starters: Frank Sullivan vs Gary Bell | Sixth | 11 out |
| Thursday, June 26 |
| » Lost to Red Sox (33-33), 2-1 | Cleveland Stadium (14-15) | 31-36 | Lost 2 |
| » Starters: Ike Delock vs Cal McLish | Sixth | 12 out |
| Friday, June 27 |
| » Defeated Orioles (29-35), 6-5 | Cleveland Stadium (15-15) | 32-36 | |
| » Manager: Joe Gordon |
| » Starters: Billy O'Dell vs Ray Narleski | Sixth | 12 out |
| Saturday, June 28 |
| » Defeated Orioles (29-36), 6-5 | Cleveland Stadium (16-15) | 33-36 | Won 2 |
| » Starters: Billy Loes vs Mudcat Grant | Sixth | 12 out |
| Sunday, June 29 |
| » Lost to Orioles (30-36), 11-6 | Cleveland Stadium (16-16) | 33-37 | |
| » Starters: Milt Pappas vs Gary Bell | Sixth | 12½ out |
| » Lost to Orioles (31-36), 5-2 | Cleveland Stadium (16-17) | 33-38 | Lost 2 |
| » Starters: Arnie Portocarrero vs Jim Constable | Sixth | 12½ out |
| Monday, June 30 |
| » Defeated White Sox (33-36), 5-3 | Comiskey Park I (2-3) | 34-38 | |
| » Starters: Cal McLish vs Dick Donovan | Sixth | 12 out |
| Tuesday, July 1 |
| » Lost to White Sox (34-36), 5-4 | Comiskey Park I (2-4) | 34-39 | |
| » Starters: Ray Narleski vs Billy Pierce | Sixth | 12½ out |
| Friday, July 4 |
| » Defeated Tigers (35-36), 6-1 | Cleveland Stadium (17-17) | 35-39 | |
| » Starters: Paul Foytack vs Cal McLish | Sixth | 14½ out |
| » Lost to Tigers (36-36), 3-1 | Cleveland Stadium (17-18) | 35-40 | |
| » Starters: Herm Wehmeier vs Mudcat Grant | Sixth | 14½ out |
| Saturday, July 5 |
| » Defeated Athletics (38-36), 8-2 | Cleveland Stadium (18-18) | 36-40 | |
| » Starters: Ralph Terry vs Ray Narleski | Sixth | 14 out |
| Sunday, July 6 |
| » Defeated Athletics (38-37), 8-5 | Cleveland Stadium (19-18) | 37-40 | Won 2 |
| » Starters: Ned Garver vs Gary Bell | Fourth | 13 out |
| Wednesday, July 9 |
| » Defeated Yankees (48-26), 12-2 | Yankee Stadium (3-2) | 38-40 | Won 3 |
| » Starters: Cal McLish vs Whitey Ford | Fourth | 12 out |
| Thursday, July 10 |
| » Lost to Yankees (49-26), 7-4 | Yankee Stadium (3-3) | 38-41 | |
| » Starters: Mudcat Grant vs Art Ditmar | Sixth | 14 out |
| » Lost to Yankees (50-26), 4-3 | Yankee Stadium (3-4) | 38-42 | Lost 2 |
| » Starters: Gary Bell vs Duke Maas | Sixth | 14 out |
| Friday, July 11 |
| » Lost to Yankees (51-26), 11-3 | Yankee Stadium (3-5) | 38-43 | Lost 3 |
| » Starters: Ray Narleski vs Bob Turley | Sixth | 15 out |
| Saturday, July 12 |
| » Lost to Yankees (52-26), 10-0 | Yankee Stadium (3-6) | 38-44 | Lost 4 |
| » Starters: Don Ferrarese vs Zach Monroe | Sixth | 16 out |
| Sunday, July 13 |
| » Defeated Red Sox (40-40), 9-4 | Fenway Park (3-4) | 39-44 | |
| » Starters: Cal McLish vs Tom Brewer | Sixth | 15½ out |
| Monday, July 14 |
| » Lost to Red Sox (41-40), 4-3 | Fenway Park (3-5) | 39-45 | |
| » Starters: Hoyt Wilhelm vs Dave Sisler | Seventh | 16½ out |
| Tuesday, July 15 |
| » Lost to Senators (36-47), 5-4 | Griffith Stadium (5-2) | 39-46 | Lost 2 |
| » Starters: Herb Score vs Russ Kemmerer | Sixth | 16½ out |
| Wednesday, July 16 |
| » Lost to Senators (37-47), 7-6 | Griffith Stadium (5-3) | 39-47 | Lost 3 |
| » Starters: Mudcat Grant vs Hal Griggs | Seventh | 17½ out |
| Thursday, July 17 |
| » Defeated Senators (37-48), 8-3 | Griffith Stadium (6-3) | 40-47 | |
| » Starters: Cal McLish vs Camilo Pascual | Seventh | 17½ out |
| Friday, July 18 |
| » Defeated Orioles (41-44), 5-1 | Memorial Stadium (3-4) | 41-47 | Won 2 |
| » Starters: Hal Woodeshick vs Charlie Beamon | Seventh | 16½ out |
| Saturday, July 19 |
| » Lost to Orioles (42-44), 3-2 | Memorial Stadium (3-5) | 41-48 | |
| » Starters: Gary Bell vs Hal Brown | Sixth | 16½ out |
| Sunday, July 20 |
| » Lost to Orioles (43-44), 3-2 | Memorial Stadium (3-6) | 41-49 | Lost 2 |
| » Starters: Hoyt Wilhelm vs Arnie Portocarrero | Seventh | 18 out |
| Tuesday, July 22 |
| » Lost to Senators (39-51), 4-2 | Cleveland Stadium (19-19) | 41-50 | Lost 3 |
| » Starters: Camilo Pascual vs Cal McLish | Sixth | 18½ out |
| » Defeated Senators (39-52), 5-3 | Cleveland Stadium (20-19) | 42-50 | |
| » Starters: John Romonosky vs Hal Woodeshick | Sixth | 18½ out |
| Wednesday, July 23 |
| » Defeated Senators (39-53), 5-3 | Cleveland Stadium (21-19) | 43-50 | Won 2 |
| » Starters: Pedro Ramos vs Mudcat Grant | Seventh | 18½ out |
| Thursday, July 24 |
| » Defeated Senators (39-54), 6-1 | Cleveland Stadium (22-19) | 44-50 | Won 3 |
| » Starters: Hal Griggs vs Gary Bell | Sixth | 18½ out |
| Friday, July 25 |
| » Lost to Yankees (62-30), 6-0 | Cleveland Stadium (22-20) | 44-51 | |
| » Starters: Whitey Ford vs Ray Narleski | Sixth | 19½ out |
| Saturday, July 26 |
| » Lost to Yankees (63-30), 8-3 | Cleveland Stadium (22-21) | 44-52 | Lost 2 |
| » Starters: Duke Maas vs Hal Woodeshick | Sixth | 20½ out |
| Sunday, July 27 |
| » Defeated Yankees (63-31), 7-2 | Cleveland Stadium (23-21) | 45-52 | |
| » Starters: Tom Sturdivant vs Cal McLish | Sixth | 18½ out |
| » Defeated Yankees (63-32), 7-2 | Cleveland Stadium (24-21) | 46-52 | Won 2 |
| » Starters: Bob Turley vs Mudcat Grant | Sixth | 18½ out |
| Tuesday, July 29 |
| » Defeated Orioles (47-47), 9-4 | Cleveland Stadium (25-21) | 47-52 | Won 3 |
| » Starters: Milt Pappas vs Gary Bell | Sixth | 18 out |
| Wednesday, July 30 |
| » Defeated Orioles (47-48), 6-3 | Cleveland Stadium (26-21) | 48-52 | Won 4 |
| » Starters: Arnie Portocarrero vs Ray Narleski | Sixth | 17 out |
| Friday, August 1 |
| » Defeated Red Sox (49-49), 7-1 | Cleveland Stadium (27-21) | 49-52 | Won 5 |
| » Starters: Frank Sullivan vs Cal McLish | Fifth | 17 out |
| » Defeated Red Sox (49-50), 3-1 | Cleveland Stadium (28-21) | 50-52 | Won 6 |
| » Starters: Dave Sisler vs Hal Woodeshick | Fifth | 17 out |
| Saturday, August 2 |
| » Defeated Red Sox (49-51), 4-1 | Cleveland Stadium (29-21) | 51-52 | Won 7 |
| » Starters: Tom Brewer vs Mudcat Grant | Second | 17 out |
| Sunday, August 3 |
| » Lost to Red Sox (50-51), 3-2 | Cleveland Stadium (29-22) | 51-53 | |
| » Starters: Ike Delock vs Gary Bell | Fifth | 17 out |
| » Lost to Red Sox (51-51), 4-2 | Cleveland Stadium (29-23) | 51-54 | Lost 2 |
| » Starters: Ted Bowsfield vs Ray Narleski | Fifth | 17 out |
| Tuesday, August 5 |
| » Defeated Tigers (50-53), 6-1 | Tiger Stadium (5-2) | 52-54 | |
| » Starters: Cal McLish vs George Susce | Fourth | 17½ out |
| Friday, August 8 |
| » Defeated Athletics (47-56), 10-4 | Cleveland Stadium (30-23) | 53-54 | Won 2 |
| » Starters: Ned Garver vs Mudcat Grant | Fourth | 18 out |
| Saturday, August 9 |
| » Defeated Athletics (47-57), 3-1 | Cleveland Stadium (31-23) | 54-54 | Won 3 |
| » Starters: Ralph Terry vs Gary Bell | Fourth | 17 out |
| Future Indian Matt Young is born in Pasadena, CA. |
| Sunday, August 10 |
| » Defeated Athletics (47-58), 11-2 | Cleveland Stadium (32-23) | 55-54 | Won 4 |
| » Starters: Jack Urban vs Cal McLish | Fourth | 17 out |
| » Lost to Athletics (48-58), 4-2 | Cleveland Stadium (32-24) | 55-55 | |
| » Starters: Bud Daley vs Hal Woodeshick | Fourth | 17 out |
| Monday, August 11 |
| » Lost to White Sox (56-54), 3-1 | Cleveland Stadium (32-25) | 55-56 | Lost 2 |
| » Starters: Billy Pierce vs Ray Narleski | Third | 16½ out |
| Tuesday, August 12 |
| » Lost to White Sox (57-54), 4-1 | Cleveland Stadium (32-26) | 55-57 | Lost 3 |
| » Starters: Early Wynn vs Mudcat Grant | Fifth | 17½ out |
| Wednesday, August 13 |
| » Lost to Tigers (55-55), 6-2 | Cleveland Stadium (32-27) | 55-58 | Lost 4 |
| » Starters: Paul Foytack vs Gary Bell | Fourth | 18 out |
| » Lost to Tigers (56-55), 3-2 | Cleveland Stadium (32-28) | 55-59 | Lost 5 |
| » Starters: Herb Moford vs Hoyt Wilhelm | Fourth | 18 out |
| Thursday, August 14 |
| » Defeated Tigers (56-56), 10-9 | Cleveland Stadium (33-28) | 56-59 | |
| » Starters: George Susce vs Cal McLish | Fourth | 18 out |
| Friday, August 15 |
| » Lost to White Sox (60-55), 4-3 | Comiskey Park I (2-5) | 56-60 | |
| » Starters: Hal Woodeshick vs Barry Latman | Fifth | 18 out |
| Saturday, August 16 |
| » Lost to White Sox (61-55), 7-6 | Comiskey Park I (2-6) | 56-61 | Lost 2 |
| » Starters: Don Ferrarese vs Early Wynn | Fifth | 18 out |
| Sunday, August 17 |
| » Lost to White Sox (62-55), 3-2 | Comiskey Park I (2-7) | 56-62 | Lost 3 |
| » Starters: Mudcat Grant vs Billy Pierce | Sixth | 18 out |
| Tuesday, August 19 |
| » Defeated Yankees (74-45), 8-6 | Yankee Stadium (4-6) | 57-62 | |
| » Starters: Cal McLish vs Whitey Ford | Fifth | 17 out |
| Wednesday, August 20 |
| » Lost to Yankees (75-45), 7-1 | Yankee Stadium (4-7) | 57-63 | |
| » Starters: Gary Bell vs Art Ditmar | Sixth | 18 out |
| Thursday, August 21 |
| » Lost to Red Sox (60-58), 8-6 | Fenway Park (3-6) | 57-64 | Lost 2 |
| » Starters: Hal Woodeshick vs Tom Brewer | Fifth | 19 out |
| Friday, August 22 |
| » Lost to Red Sox (61-58), 4-3 | Fenway Park (3-7) | 57-65 | Lost 3 |
| » Starters: Hoyt Wilhelm vs Ike Delock | Seventh | 20 out |
| Former Indian Dummy Taylor dies in Jacksonville, IL at the age of 84. |
| Saturday, August 23 |
| » Defeated Red Sox (61-59), 8-1 | Fenway Park (4-7) | 58-65 | |
| » Starters: Cal McLish vs Dave Sisler | Fifth | 19 out |
| Future Indian Julio Franco is born in Hato Mayor, D.R. |
| Sunday, August 24 |
| » Defeated Senators (51-71), 9-1 | Griffith Stadium (7-3) | 59-65 | Won 2 |
| » Starters: Mudcat Grant vs Pedro Ramos | Sixth | 18½ out |
| Monday, August 25 |
| » Lost to Senators (52-71), 5-4 | Griffith Stadium (7-4) | 59-66 | |
| » Starters: Gary Bell vs Vito Valentinetti | Sixth | 19 out |
| Tuesday, August 26 |
| » Lost to Orioles (61-62), 1-0 | Memorial Stadium (3-7) | 59-67 | Lost 2 |
| » Starters: Don Ferrarese vs Hal Brown | Sixth | 20 out |
| Wednesday, August 27 |
| » Defeated Orioles (61-63), 8-5 | Memorial Stadium (4-7) | 60-67 | |
| » Starters: Cal McLish vs Connie Johnson | Sixth | 19 out |
| Friday, August 29 |
| » Lost to Athletics (59-67), 8-7 | Municipal Stadium (1-6) | 60-68 | |
| » Starters: Hal Woodeshick vs Bob Grim | Sixth | 19 out |
| Saturday, August 30 |
| » Defeated Athletics (59-68), 8-6 | Municipal Stadium (2-6) | 61-68 | |
| » Starters: Mudcat Grant vs Ned Garver | Sixth | 18 out |
| Sunday, August 31 |
| » Defeated Athletics (59-69), 3-2 | Municipal Stadium (3-6) | 62-68 | Won 2 |
| » Starters: Cal McLish vs Ralph Terry | Sixth | 18 out |
| Future Indian Von Hayes is born in Stockton, CA. |
| Monday, September 1 |
| » Defeated White Sox (69-61), 6-5 | Comiskey Park I (3-7) | 63-68 | Won 3 |
| » Starters: Don Ferrarese vs Billy Pierce | Sixth | 17 out |
| » Defeated White Sox (69-62), 7-1 | Comiskey Park I (4-7) | 64-68 | Won 4 |
| » Starters: Gary Bell vs Bob Shaw | Sixth | 17 out |
| Wednesday, September 3 |
| » Lost to Athletics (60-72), 6-2 | Cleveland Stadium (33-29) | 64-69 | |
| » Starters: Ray Herbert vs Hal Woodeshick | Sixth | 18½ out |
| Thursday, September 4 |
| » Lost to Athletics (61-72), 2-1 | Cleveland Stadium (33-30) | 64-70 | Lost 2 |
| » Starters: Ralph Terry vs Cal McLish | Fifth | 19 out |
| Friday, September 5 |
| » Lost to White Sox (71-63), 4-3 | Cleveland Stadium (33-31) | 64-71 | Lost 3 |
| » Starters: Early Wynn vs Don Mossi | Sixth | 19 out |
| Saturday, September 6 |
| » Defeated White Sox (71-64), 7-1 | Cleveland Stadium (34-31) | 65-71 | |
| » Starters: Billy Pierce vs Gary Bell | Fifth | 18 out |
| Sunday, September 7 |
| » Defeated White Sox (71-65), 4-3 | Cleveland Stadium (35-31) | 66-71 | Won 2 |
| » Starters: Dick Donovan vs Don Ferrarese | Fifth | 17½ out |
| Tuesday, September 9 |
| » Defeated Yankees (84-55), 9-2 | Cleveland Stadium (36-31) | 67-71 | Won 3 |
| » Starters: Murry Dickson vs Cal McLish | Fifth | 16½ out |
| Wednesday, September 10 |
| » Lost to Yankees (85-55), 8-3 | Cleveland Stadium (36-32) | 67-72 | |
| » Starters: Zach Monroe vs Don Mossi | Sixth | 17½ out |
| Thursday, September 11 |
| » Major-league debuts: George Alusik (Tigers) |
| Friday, September 12 |
| » Defeated Red Sox (70-69), 5-4 | Cleveland Stadium (37-32) | 68-72 | |
| » Starters: Ted Bowsfield vs Gary Bell | Fifth | 17½ out |
| Saturday, September 13 |
| » Defeated Red Sox (70-70), 4-1 | Cleveland Stadium (38-32) | 69-72 | Won 2 |
| » Starters: Dave Sisler vs Cal McLish | Fifth | 17½ out |
| Sunday, September 14 |
| » Defeated Orioles (66-75), 7-4 | Cleveland Stadium (39-32) | 70-72 | Won 3 |
| » Starters: Connie Johnson vs Don Ferrarese | Fifth | 18½ out |
| » Lost to Orioles (67-75), 4-2 | Cleveland Stadium (39-33) | 70-73 | |
| » Starters: Arnie Portocarrero vs Mudcat Grant | Fifth | 18½ out |
| Monday, September 15 |
| Former Indian Snuffy Stirnweiss dies in Newark Bay, NJ at the age of 40. |
| Tuesday, September 16 |
| » Defeated Senators (61-83), 5-1 | Cleveland Stadium (40-33) | 71-73 | |
| » Starters: Pedro Ramos vs Gary Bell | Fifth | 17½ out |
| » Major-league debuts: Bob Allison (Senators) |
| Future Indian Orel Hershiser is born in Buffalo, NY. |
| Wednesday, September 17 |
| Future Indian Tom Waddell is born in Dundee, Scotland. |
| Friday, September 19 |
| » Defeated Tigers (73-72), 2-1 | Tiger Stadium (6-2) | 72-73 | Won 2 |
| » Starters: Cal McLish vs Paul Foytack | Fourth | 16 out |
| Saturday, September 20 |
| » Defeated Tigers (73-73), 2-1 | Tiger Stadium (7-2) | 73-73 | Won 3 |
| » Starters: Don Ferrarese vs Frank Lary | Fourth | 15½ out |
| » Lost to Tigers (74-73), 4-1 | Tiger Stadium (7-3) | 73-74 | |
| » Starters: Gary Bell vs Billy Hoeft | Fourth | 15½ out |
| Sunday, September 21 |
| » Defeated Tigers (74-74), 3-1 | Tiger Stadium (8-3) | 74-74 | |
| » Starters: Ray Narleski vs Jim Bunning | Third | 14½ out |
| Tuesday, September 23 |
| » Defeated Athletics (71-79), 7-5 | Municipal Stadium (4-6) | 75-74 | Won 2 |
| » Starters: Cal McLish vs Ned Garver | Third | 13½ out |
| Wednesday, September 24 |
| » Lost to Athletics (72-79), 7-4 | Municipal Stadium (4-7) | 75-75 | |
| » Starters: Gary Bell vs Ralph Terry | Third | 14½ out |
| Friday, September 26 |
| » Defeated Tigers (76-76), 5-4 | Cleveland Stadium (41-33) | 76-75 | |
| » Starters: Billy Hoeft vs Don Ferrarese | Fourth | 13½ out |
| Saturday, September 27 |
| » Lost to Tigers (77-76), 5-1 | Cleveland Stadium (41-34) | 76-76 | |
| » Starters: Paul Foytack vs Cal McLish | Fifth | 14 out |
| Former Indian Joe Berry dies in Anaheim, CA at the age of 54. |
| Sunday, September 28 |
| » Defeated Tigers (77-77), 6-2 | Cleveland Stadium (42-34) | 77-76 | |
| » Starters: Jim Bunning vs Gary Bell | Fourth | 14½ out |
| Saturday, October 25 |
| Future Indian Dave Von Ohlen is born in Flushing, NY. |
| Sunday, October 26 |
| Future Indian |
