| Monday, January 13 |
| Future Cardinal Gene Roof is born in Paducah, KY. |
| Friday, January 24 |
| Future Cardinal Neil Allen is born in Kansas City, KS. |
| Friday, January 31 |
| Future Cardinal Rafael Santana is born in La Romana, D.R. |
| Thursday, February 6 |
| Future Cardinal Bill Dawley is born in Norwich, CT. |
| Sunday, February 9 |
| Former Cardinal Cowboy Jones dies in Inglewood, CA at the age of 84. |
| Monday, February 10 |
| Former Cardinal Elmer Jacobs dies in Salem, MO at the age of 66. |
| Sunday, February 23 |
| Future Cardinal Juan Agosto is born in Rio Piedras, P.R. |
| Thursday, March 20 |
| Former Cardinal Gene Dale dies in St.Louis, MO at the age of 69. |
| Monday, April 14 |
| » Major-league debuts: Albie Pearson (Senators) |
| Tuesday, April 15 |
| » Lost to Cubs (1-0), 4-0 | Sportsman's Park III (0-1) | 0-1 | |
| » Starters: Jim Brosnan vs Vinegar Bend Mizell | Second | 1 out |
| » Major-league debuts: Phil Clark (Cardinals) Tony Taylor (Cubs) |
| Wednesday, April 16 |
| » Major-league debuts: Bob Schmidt (Giants) |
| Thursday, April 17 |
| » Lost to Cubs (2-0), 4-3 | Sportsman's Park III (0-2) | 0-2 | Lost 2 |
| » Starters: Glen Hobbie vs Lindy McDaniel | Seventh | 2 out |
| Friday, April 18 |
| » Lost to Cubs (3-0), 11-6 | Wrigley Field (0-1) | 0-3 | Lost 3 |
| » Starters: Sam Jones vs Dick Drott | Sixth | 3 out |
| » Major-league debuts: Bob Mabe (Cardinals) |
| Saturday, April 19 |
| » Lost to Cubs (4-0), 6-3 | Wrigley Field (0-2) | 0-4 | Lost 4 |
| » Starters: Vinegar Bend Mizell vs Taylor Phillips | Eighth | 4 out |
| Sunday, April 20 |
| » Defeated Cubs (4-1), 9-4 | Wrigley Field (1-2) | 1-4 | |
| » Starters: Herm Wehmeier vs Jim Brosnan | Seventh | 3 out |
| Tuesday, April 22 |
| » Defeated Giants (4-3), 7-5 | Seals Stadium (1-0) | 2-4 | Won 2 |
| » Starters: Lindy McDaniel vs Johnny Antonelli | Sixth | 2 out |
| Wednesday, April 23 |
| » Lost to Giants (5-3), 8-7 | Seals Stadium (1-1) | 2-5 | |
| » Starters: Sam Jones vs Ruben Gomez | Seventh | 3 out |
| » Major-league debuts: Don Taussig and Nick Testa (Giants) |
| Thursday, April 24 |
| » Lost to Giants (6-3), 6-5 | Seals Stadium (1-2) | 2-6 | Lost 2 |
| » Starters: Vinegar Bend Mizell vs Pete Burnside | Eighth | 4 out |
| Friday, April 25 |
| » Lost to Dodgers (4-6), 5-3 | Los Angeles Memorial Coliseum (0-1) | 2-7 | Lost 3 |
| » Starters: Herm Wehmeier vs Fred Kipp | Seventh | 4½ out |
| Saturday, April 26 |
| » Defeated Dodgers (4-7), 6-4 | Los Angeles Memorial Coliseum (1-1) | 3-7 | |
| » Starters: Lindy McDaniel vs Danny McDevitt | Eighth | 4½ out |
| Sunday, April 27 |
| » Lost to Dodgers (5-7), 10-3 | Los Angeles Memorial Coliseum (1-2) | 3-8 | |
| » Starters: Sam Jones vs Johnny Podres | Seventh | 4½ out |
| Tuesday, April 29 |
| » Lost to Reds (5-5), 5-2 | Crosley Field (0-1) | 3-9 | Lost 2 |
| » Starters: Vinegar Bend Mizell vs Bob Purkey | Eighth | 5 out |
| Wednesday, April 30 |
| » Lost to Reds (6-5), 5-4 | Crosley Field (0-2) | 3-10 | Lost 3 |
| » Starters: Lindy McDaniel vs Joe Nuxhall | Seventh | 5½ out |
| Friday, May 2 |
| » Lost to Reds (7-5), 7-3 | Sportsman's Park III (0-3) | 3-11 | Lost 4 |
| » Starters: Brooks Lawrence vs Sam Jones | Eighth | 6½ out |
| Sunday, May 4 |
| » Lost to Braves (10-7), 7-2 | Sportsman's Park III (0-4) | 3-12 | Lost 5 |
| » Starters: Warren Spahn vs Vinegar Bend Mizell | Seventh | 6½ out |
| Tuesday, May 6 |
| » Lost to Braves (11-7), 12-8 | Sportsman's Park III (0-5) | 3-13 | Lost 6 |
| » Starters: Bob Buhl vs Lindy McDaniel | Eighth | 7½ out |
| Wednesday, May 7 |
| » Lost to Braves (12-7), 9-2 | Sportsman's Park III (0-6) | 3-14 | Lost 7 |
| » Starters: Lew Burdette vs Herm Wehmeier | Eighth | 8½ out |
| Friday, May 9 |
| » Defeated Cubs (13-9), 3-2 | Sportsman's Park III (1-6) | 4-14 | |
| » Starters: Moe Drabowsky vs Sam Jones | Eighth | 8 out |
| Saturday, May 10 |
| » Defeated Cubs (13-10), 3-1 | Sportsman's Park III (2-6) | 5-14 | Won 2 |
| » Starters: Jim Brosnan vs Vinegar Bend Mizell | Eighth | 8 out |
| Sunday, May 11 |
| » Defeated Cubs (13-11), 8-7 | Sportsman's Park III (3-6) | 6-14 | Won 3 |
| » Starters: Glen Hobbie vs Von McDaniel | Sixth | 7½ out |
| » Defeated Cubs (13-12), 6-5 | Sportsman's Park III (4-6) | 7-14 | Won 4 |
| » Starters: Taylor Phillips vs Lindy McDaniel | Sixth | 7½ out |
| Monday, May 12 |
| » Defeated Cubs (13-13), 6-4 | Wrigley Field (2-2) | 8-14 | Won 5 |
| » Starters: Frank Barnes vs Glen Hobbie | Seventh | 7 out |
| Tuesday, May 13 |
| » Defeated Cubs (13-14), 5-3 | Wrigley Field (3-2) | 9-14 | Won 6 |
| » Starters: Sam Jones vs Moe Drabowsky | Seventh | 6½ out |
| Wednesday, May 14 |
| » Defeated Giants (17-10), 3-2 | Sportsman's Park III (5-6) | 10-14 | Won 7 |
| » Starters: Johnny Antonelli vs Vinegar Bend Mizell | Fifth | 6 out |
| Thursday, May 15 |
| » Lost to Giants (18-10), 4-2 | Sportsman's Park III (5-7) | 10-15 | |
| » Starters: Mike McCormick vs Lindy McDaniel | Sixth | 6½ out |
| Friday, May 16 |
| » Defeated Dodgers (10-19), 2-0 | Sportsman's Park III (6-7) | 11-15 | |
| » Starters: Johnny Podres vs Sam Jones | Sixth | 6 out |
| Saturday, May 17 |
| » Defeated Dodgers (10-20), 10-1 | Sportsman's Park III (7-7) | 12-15 | Won 2 |
| » Starters: Don Newcombe vs Larry Jackson | Fifth | 6 out |
| » Major-league debuts: Stan Williams (Dodgers) |
| Sunday, May 18 |
| » Defeated Dodgers (10-21), 6-5 | Sportsman's Park III (8-7) | 13-15 | Won 3 |
| » Starters: Fred Kipp vs Bob Mabe | Sixth | 6½ out |
| » Lost to Dodgers (11-21), 4-0 | Sportsman's Park III (8-8) | 13-16 | |
| » Starters: Carl Erskine vs Vinegar Bend Mizell | Sixth | 6½ out |
| Tuesday, May 20 |
| » Defeated Phillies (14-17), 5-0 | Shibe Park (1-0) | 14-16 | |
| » Starters: Lindy McDaniel vs Curt Simmons | Fourth | 6½ out |
| Wednesday, May 21 |
| » Lost to Phillies (15-17), 1-0 | Shibe Park (1-1) | 14-17 | |
| » Starters: Sam Jones vs Robin Roberts | Sixth | 7½ out |
| Friday, May 23 |
| » Lost to Pirates (19-15), 3-2 | Forbes Field (0-1) | 14-18 | Lost 2 |
| » Starters: Vinegar Bend Mizell vs Ron Kline | Sixth | 8 out |
| Saturday, May 24 |
| » Lost to Pirates (20-15), 6-1 | Forbes Field (0-2) | 14-19 | Lost 3 |
| » Starters: Larry Jackson vs Bob Friend | Seventh | 8 out |
| Sunday, May 25 |
| » Defeated Reds (13-18), 4-2 | Crosley Field (1-2) | 15-19 | |
| » Starters: Jim Brosnan vs Charlie Rabe | Seventh | 9 out |
| » Lost to Reds (14-18), 7-3 | Crosley Field (1-3) | 15-20 | |
| » Starters: Lindy McDaniel vs Harvey Haddix | Seventh | 9 out |
| Tuesday, May 27 |
| » Lost to Braves (23-13), 3-2 | County Stadium (0-1) | 15-21 | Lost 2 |
| » Starters: Sam Jones vs Warren Spahn | Seventh | 9 out |
| Wednesday, May 28 |
| » Defeated Braves (23-14), 7-4 | County Stadium (1-1) | 16-21 | |
| » Starters: Larry Jackson vs Gene Conley | Seventh | 9 out |
| Friday, May 30 |
| » Defeated Giants (27-15), 7-6 | Sportsman's Park III (9-8) | 17-21 | Won 2 |
| » Starters: Ruben Gomez vs Vinegar Bend Mizell | Fifth | 7 out |
| » Defeated Giants (27-16), 8-1 | Sportsman's Park III (10-8) | 18-21 | Won 3 |
| » Starters: Mike McCormick vs Jim Brosnan | Fifth | 7 out |
| Saturday, May 31 |
| » Defeated Giants (27-17), 10-9 | Sportsman's Park III (11-8) | 19-21 | Won 4 |
| » Starters: Ramon Monzant vs Lindy McDaniel | Fifth | 6 out |
| Sunday, June 1 |
| » Lost to Giants (28-17), 7-2 | Sportsman's Park III (11-9) | 19-22 | |
| » Starters: Johnny Antonelli vs Sam Jones | Sixth | 7 out |
| Tuesday, June 3 |
| » Defeated Pirates (23-22), 8-4 | Sportsman's Park III (12-9) | 20-22 | |
| » Starters: Vern Law vs Larry Jackson | Sixth | 6 out |
| Wednesday, June 4 |
| » Defeated Pirates (23-23), 6-3 | Sportsman's Park III (13-9) | 21-22 | Won 2 |
| » Starters: Ron Kline vs Jim Brosnan | Sixth | 6 out |
| Thursday, June 5 |
| » Defeated Pirates (23-24), 4-3 | Sportsman's Park III (14-9) | 22-22 | Won 3 |
| » Starters: Bob Friend vs Vinegar Bend Mizell | Fourth | 5 out |
| Friday, June 6 |
| » Defeated Phillies (19-27), 3-1 | Sportsman's Park III (15-9) | 23-22 | Won 4 |
| » Starters: Seth Morehead vs Sam Jones | Fourth | 4 out |
| Saturday, June 7 |
| » Lost to Phillies (20-27), 15-6 | Sportsman's Park III (15-10) | 23-23 | |
| » Starters: Curt Simmons vs Lindy McDaniel | Fourth | 5 out |
| Sunday, June 8 |
| » Defeated Phillies (20-28), 6-5 | Sportsman's Park III (16-10) | 24-23 | |
| » Starters: Robin Roberts vs Larry Jackson | Fourth | 4½ out |
| » Lost to Phillies (21-28), 6-4 | Sportsman's Park III (16-11) | 24-24 | |
| » Starters: Jack Sanford vs Jim Brosnan | Fourth | 4½ out |
| Wednesday, June 11 |
| » Defeated Reds (24-23), 3-2 | Sportsman's Park III (17-11) | 25-24 | |
| » Starters: Joe Nuxhall vs Sam Jones | Fourth | 3 out |
| Thursday, June 12 |
| » Lost to Reds (25-23), 5-0 | Sportsman's Park III (17-12) | 25-25 | |
| » Starters: Brooks Lawrence vs Vinegar Bend Mizell | Fifth | 4 out |
| Friday, June 13 |
| » Lost to Braves (30-21), 2-0 | Sportsman's Park III (17-13) | 25-26 | Lost 2 |
| » Starters: Joey Jay vs Jim Brosnan | Fifth | 5 out |
| Saturday, June 14 |
| » Defeated Braves (30-22), 2-1 | Sportsman's Park III (18-13) | 26-26 | |
| » Starters: Warren Spahn vs Larry Jackson | Fourth | 4 out |
| Sunday, June 15 |
| » Lost to Braves (31-22), 4-2 | Sportsman's Park III (18-14) | 26-27 | |
| » Starters: Bob Rush vs Sam Jones | Fifth | 5 out |
| Monday, June 16 |
| » Defeated Reds (27-25), 6-5 | Crosley Field (2-3) | 27-27 | |
| » Starters: Vinegar Bend Mizell vs Joe Nuxhall | Fourth | 4½ out |
| Tuesday, June 17 |
| » Defeated Reds (27-26), 10-4 | Crosley Field (3-3) | 28-27 | Won 2 |
| » Starters: Jim Brosnan vs Brooks Lawrence | Fourth | 4½ out |
| Wednesday, June 18 |
| » Lost to Reds (28-26), 6-1 | Crosley Field (3-4) | 28-28 | |
| » Starters: Larry Jackson vs Don Newcombe | Fourth | 5 out |
| Friday, June 20 |
| » Lost to Braves (33-23), 7-3 | County Stadium (1-2) | 28-29 | Lost 2 |
| » Starters: Sam Jones vs Bob Rush | Fifth | 5½ out |
| Saturday, June 21 |
| » Defeated Braves (33-24), 2-1 | County Stadium (2-2) | 29-29 | |
| » Starters: Vinegar Bend Mizell vs Lew Burdette | Fifth | 4½ out |
| Sunday, June 22 |
| » Defeated Braves (33-25), 2-1 | County Stadium (3-2) | 30-29 | Won 2 |
| » Starters: Sal Maglie vs Joey Jay | Fifth | 3½ out |
| Monday, June 23 |
| » Defeated Pirates (32-32), 7-5 | Forbes Field (1-2) | 31-29 | Won 3 |
| » Starters: Jim Brosnan vs Don Gross | Fourth | 3½ out |
| Tuesday, June 24 |
| » Defeated Pirates (32-33), 2-1 | Forbes Field (2-2) | 32-29 | Won 4 |
| » Starters: Sam Jones vs Ron Kline | Second | 3½ out |
| Wednesday, June 25 |
| » Defeated Pirates (32-34), 3-1 | Forbes Field (3-2) | 33-29 | Won 5 |
| » Starters: Vinegar Bend Mizell vs George Witt | Second | 2½ out |
| Thursday, June 26 |
| » Defeated Pirates (32-35), 6-2 | Forbes Field (4-2) | 34-29 | Won 6 |
| » Starters: Lindy McDaniel vs Vern Law | Second | 1½ out |
| Friday, June 27 |
| » Lost to Phillies (30-34), 5-4 | Shibe Park (1-2) | 34-30 | |
| » Starters: Jim Brosnan vs Robin Roberts | Second | 1½ out |
| Saturday, June 28 |
| » Defeated Phillies (30-35), 8-1 | Shibe Park (2-2) | 35-30 | |
| » Starters: Sal Maglie vs Curt Simmons | Second | 1½ out |
| Sunday, June 29 |
| » Lost to Phillies (31-35), 5-4 | Shibe Park (2-3) | 35-31 | |
| » Starters: Sam Jones vs Seth Morehead | Second | 2 out |
| » Defeated Phillies (31-36), 4-3 | Shibe Park (3-3) | 36-31 | |
| » Starters: Vinegar Bend Mizell vs Jack Sanford | Second | 2 out |
| » Major-league debuts: Ruben Amaro (Cardinals) |
| Monday, June 30 |
| » Defeated Dodgers (31-39), 4-2 | Sportsman's Park III (19-14) | 37-31 | Won 2 |
| » Starters: Bob Giallombardo vs Lindy McDaniel | Second | 2 out |
| Tuesday, July 1 |
| » Lost to Dodgers (32-39), 9-3 | Sportsman's Park III (19-15) | 37-32 | |
| » Starters: Sandy Koufax vs Jim Brosnan | Second | 3 out |
| Thursday, July 3 |
| » Defeated Dodgers (32-40), 4-2 | Los Angeles Memorial Coliseum (2-2) | 38-32 | |
| » Starters: Sam Jones vs Stan Williams | Second | 2 out |
| » Lost to Dodgers (33-40), 3-2 | Los Angeles Memorial Coliseum (2-3) | 38-33 | |
| » Starters: Sal Maglie vs Johnny Podres | Second | 2 out |
| Saturday, July 5 |
| » Lost to Giants (40-37), 5-4 | Seals Stadium (1-3) | 38-34 | Lost 2 |
| » Starters: Lindy McDaniel vs Mike McCormick | Second | 1 out |
| Sunday, July 6 |
| » Lost to Giants (41-37), 5-4 | Seals Stadium (1-4) | 38-35 | Lost 3 |
| » Starters: Jim Brosnan vs Stu Miller | Third | 2 out |
| Thursday, July 10 |
| » Lost to Phillies (38-37), 13-3 | Sportsman's Park III (19-16) | 38-36 | Lost 4 |
| » Starters: Robin Roberts vs Sal Maglie | Third | 2½ out |
| Friday, July 11 |
| » Defeated Phillies (38-38), 6-2 | Sportsman's Park III (20-16) | 39-36 | |
| » Starters: Jack Sanford vs Sam Jones | Third | 2½ out |
| Saturday, July 12 |
| » Defeated Pirates (37-43), 2-0 | Sportsman's Park III (21-16) | 40-36 | Won 2 |
| » Starters: Bob Friend vs Vinegar Bend Mizell | Third | 1½ out |
| Sunday, July 13 |
| » Lost to Pirates (38-43), 10-8 | Sportsman's Park III (21-17) | 40-37 | |
| » Starters: Curt Raydon vs Jim Brosnan | Third | 2 out |
| » Lost to Pirates (39-43), 8-6 | Sportsman's Park III (21-18) | 40-38 | Lost 2 |
| » Starters: George Witt vs Lindy McDaniel | Third | 2 out |
| Tuesday, July 15 |
| » Lost to Braves (44-36), 4-1 | Sportsman's Park III (21-19) | 40-39 | Lost 3 |
| » Starters: Joey Jay vs Sal Maglie | Fourth | 3½ out |
| Wednesday, July 16 |
| » Lost to Braves (45-36), 6-5 | Sportsman's Park III (21-20) | 40-40 | Lost 4 |
| » Starters: Warren Spahn vs Sam Jones | Fourth | 4½ out |
| Thursday, July 17 |
| » Lost to Braves (46-36), 8-7 | Sportsman's Park III (21-21) | 40-41 | Lost 5 |
| » Starters: Bob Rush vs Lindy McDaniel | Fourth | 5½ out |
| Friday, July 18 |
| » Lost to Reds (40-44), 8-3 | Crosley Field (3-5) | 40-42 | Lost 6 |
| » Starters: Vinegar Bend Mizell vs Don Newcombe | Fourth | 6 out |
| » Lost to Reds (41-44), 2-1 | Crosley Field (3-6) | 40-43 | Lost 7 |
| » Starters: Bob Mabe vs Bob Purkey | Fourth | 6 out |
| Saturday, July 19 |
| » Defeated Reds (41-45), 1-0 | Crosley Field (4-6) | 41-43 | |
| » Starters: Larry Jackson vs Alex Kellner | Fourth | 6 out |
| Sunday, July 20 |
| » Defeated Reds (41-46), 3-1 | Crosley Field (5-6) | 42-43 | Won 2 |
| » Starters: Sam Jones vs Brooks Lawrence | Fourth | 6 out |
| Monday, July 21 |
| » Defeated Braves (48-38), 5-4 | County Stadium (4-2) | 43-43 | Won 3 |
| » Starters: Lindy McDaniel vs Lew Burdette | Fourth | 5½ out |
| Tuesday, July 22 |
| » Lost to Braves (49-38), 2-1 | County Stadium (4-3) | 43-44 | |
| » Starters: Bob Mabe vs Carl Willey | Fourth | 6 out |
| Wednesday, July 23 |
| » Lost to Braves (50-38), 6-0 | County Stadium (4-4) | 43-45 | Lost 2 |
| » Starters: Larry Jackson vs Joey Jay | Fourth | 7 out |
| Thursday, July 24 |
| » Defeated Braves (50-39), 4-0 | County Stadium (5-4) | 44-45 | |
| » Starters: Sam Jones vs Warren Spahn | Fourth | 6 out |
| Friday, July 25 |
| » Defeated Reds (44-47), 5-4 | Sportsman's Park III (22-21) | 45-45 | Won 2 |
| » Starters: Don Newcombe vs Bill Wight | Third | 6 out |
| » Lost to Reds (45-47), 3-2 | Sportsman's Park III (22-22) | 45-46 | |
| » Starters: Bob Purkey vs Billy Muffett | Third | 6 out |
| Saturday, July 26 |
| » Lost to Reds (46-47), 2-1 | Sportsman's Park III (22-23) | 45-47 | Lost 2 |
| » Starters: Harvey Haddix vs Vinegar Bend Mizell | Fourth | 6 out |
| Sunday, July 27 |
| » Defeated Reds (46-48), 4-3 | Sportsman's Park III (23-23) | 46-47 | |
| » Starters: Joe Nuxhall vs Larry Jackson | Fifth | 6½ out |
| » Lost to Reds (47-48), 10-1 | Sportsman's Park III (23-24) | 46-48 | |
| » Starters: Alex Kellner vs Bob Mabe | Fifth | 6½ out |
| Tuesday, July 29 |
| » Lost to Phillies (44-50), 3-2 | Shibe Park (3-4) | 46-49 | Lost 2 |
| » Starters: Sam Jones vs Don Cardwell | Sixth | 7 out |
| Wednesday, July 30 |
| » Lost to Phillies (45-50), 5-1 | Shibe Park (3-5) | 46-50 | Lost 3 |
| » Starters: Billy Muffett vs Jack Sanford | Sixth | 7½ out |
| Thursday, July 31 |
| » Lost to Phillies (46-50), 4-3 | Shibe Park (3-6) | 46-51 | Lost 4 |
| » Starters: Larry Jackson vs Jim Hearn | Sixth | 8½ out |
| Friday, August 1 |
| » Lost to Pirates (50-49), 2-0 | Forbes Field (4-3) | 46-52 | Lost 5 |
| » Starters: Bob Mabe vs Ron Kline | Seventh | 9½ out |
| Saturday, August 2 |
| » Lost to Pirates (51-49), 1-0 | Forbes Field (4-4) | 46-53 | Lost 6 |
| » Starters: Sam Jones vs Vern Law | Seventh | 10½ out |
| Sunday, August 3 |
| » Lost to Pirates (52-49), 2-0 | Forbes Field (4-5) | 46-54 | Lost 7 |
| » Starters: Sal Maglie vs Bob Friend | Eighth | 12½ out |
| » Lost to Pirates (53-49), 2-1 | Forbes Field (4-6) | 46-55 | Lost 8 |
| » Starters: Vinegar Bend Mizell vs George Witt | Eighth | 12½ out |
| Monday, August 4 |
| » Defeated Dodgers (47-56), 3-2 | Sportsman's Park III (24-24) | 47-55 | |
| » Starters: Johnny Podres vs Larry Jackson | Seventh | 11½ out |
| Tuesday, August 5 |
| » Defeated Dodgers (47-57), 13-3 | Sportsman's Park III (25-24) | 48-55 | Won 2 |
| » Starters: Danny McDevitt vs Billy Muffett | Seventh | 11½ out |
| Wednesday, August 6 |
| » Defeated Giants (55-51), 8-7 | Sportsman's Park III (26-24) | 49-55 | Won 3 |
| » Starters: Al Worthington vs Bob Mabe | Seventh | 11½ out |
| Thursday, August 7 |
| » Defeated Giants (55-52), 12-1 | Sportsman's Park III (27-24) | 50-55 | Won 4 |
| » Starters: Mike McCormick vs Sam Jones | Seventh | 11½ out |
| Friday, August 8 |
| » Defeated Cubs (52-57), 6-3 | Wrigley Field (4-2) | 51-55 | Won 5 |
| » Starters: Vinegar Bend Mizell vs Dick Drott | Fifth | 10½ out |
| Saturday, August 9 |
| » Defeated Cubs (52-58), 3-2 | Wrigley Field (5-2) | 52-55 | Won 6 |
| » Starters: Sal Maglie vs Glen Hobbie | Fifth | 9½ out |
| Sunday, August 10 |
| » Lost to Cubs (53-58), 9-4 | Wrigley Field (5-3) | 52-56 | |
| » Starters: Billy Muffett vs John Briggs | Fifth | 10½ out |
| » Defeated Cubs (53-59), 6-2 | Wrigley Field (6-3) | 53-56 | |
| » Starters: Larry Jackson vs Dave Hillman | Fifth | 10½ out |
| Tuesday, August 12 |
| » Defeated Giants (57-54), 7-3 | Seals Stadium (2-4) | 54-56 | Won 2 |
| » Starters: Sam Jones vs Mike McCormick | Fourth | 9 out |
| Wednesday, August 13 |
| » Lost to Giants (58-54), 11-2 | Seals Stadium (2-5) | 54-57 | |
| » Starters: Vinegar Bend Mizell vs Ruben Gomez | Fourth | 10½ out |
| Thursday, August 14 |
| » Lost to Giants (59-54), 4-3 | Seals Stadium (2-6) | 54-58 | Lost 2 |
| » Starters: Billy Muffett vs Johnny Antonelli | Fifth | 11½ out |
| Friday, August 15 |
| » Lost to Dodgers (53-60), 4-3 | Los Angeles Memorial Coliseum (2-4) | 54-59 | Lost 3 |
| » Starters: Larry Jackson vs Johnny Podres | Fifth | 13 out |
| » Lost to Dodgers (54-60), 5-3 | Los Angeles Memorial Coliseum (2-5) | 54-60 | Lost 4 |
| » Starters: Sal Maglie vs Stan Williams | Fifth | 13 out |
| Sunday, August 17 |
| » Defeated Dodgers (54-61), 12-7 | Los Angeles Memorial Coliseum (3-5) | 55-60 | |
| » Starters: Nelson Chittum vs Sandy Koufax | Fourth | 14½ out |
| » Lost to Dodgers (55-61), 9-3 | Los Angeles Memorial Coliseum (3-6) | 55-61 | |
| » Starters: Sam Jones vs Danny McDevitt | Fourth | 14½ out |
| Tuesday, August 19 |
| » Defeated Phillies (53-62), 5-4 | Sportsman's Park III (28-24) | 56-61 | |
| » Starters: Jack Sanford vs Vinegar Bend Mizell | Fifth | 13 out |
| Future Cardinal Luis DeLeon is born in Ponce, P.R. Future Cardinal Gary Gaetti is born in Centralia, IL. |
| Wednesday, August 20 |
| » Lost to Phillies (54-62), 12-2 | Sportsman's Park III (28-25) | 56-62 | |
| » Starters: Robin Roberts vs Billy Muffett | Fifth | 13 out |
| Thursday, August 21 |
| » Defeated Phillies (54-63), 2-1 | Sportsman's Park III (29-25) | 57-62 | |
| » Starters: Curt Simmons vs Larry Jackson | Fifth | 13 out |
| Friday, August 22 |
| » Defeated Phillies (54-64), 9-1 | Sportsman's Park III (30-25) | 58-62 | Won 2 |
| » Starters: Don Cardwell vs Sam Jones | Fourth | 12½ out |
| Saturday, August 23 |
| » Lost to Phillies (55-64), 4-2 | Sportsman's Park III (30-26) | 58-63 | |
| » Starters: Seth Morehead vs Sal Maglie | Fifth | 12½ out |
| Sunday, August 24 |
| » Lost to Pirates (67-57), 8-4 | Sportsman's Park III (30-27) | 58-64 | Lost 2 |
| » Starters: Bob Friend vs Vinegar Bend Mizell | Fifth | 13 out |
| » Defeated Pirates (67-58), 12-8 | Sportsman's Park III (31-27) | 59-64 | |
| » Starters: Curt Raydon vs Bob Mabe | Fifth | 13 out |
| Monday, August 25 |
| » Defeated Pirates (67-59), 7-1 | Sportsman's Park III (32-27) | 60-64 | Won 2 |
| » Starters: Ron Kline vs Larry Jackson | Fifth | 13 out |
| Tuesday, August 26 |
| » Lost to Pirates (68-59), 5-3 | Sportsman's Park III (32-28) | 60-65 | |
| » Starters: George Witt vs Sam Jones | Fifth | 14 out |
| Wednesday, August 27 |
| » Lost to Pirates (69-59), 14-1 | Sportsman's Park III (32-29) | 60-66 | Lost 2 |
| » Starters: Bob Porterfield vs Nelson Chittum | Fifth | 14 out |
| Friday, August 29 |
| » Defeated Cubs (58-71), 7-5 | Sportsman's Park III (33-29) | 61-66 | |
| » Starters: Dick Drott vs Larry Jackson | Fifth | 13½ out |
| Saturday, August 30 |
| » Lost to Cubs (59-71), 3-1 | Sportsman's Park III (33-30) | 61-67 | |
| » Starters: Dave Hillman vs Sam Jones | Fifth | 14½ out |
| Former Cardinal Frank Demaree dies in Los Angeles, CA at the age of 49. |
| Sunday, August 31 |
| » Lost to Cubs (60-71), 8-5 | Sportsman's Park III (33-31) | 61-68 | Lost 2 |
| » Starters: Moe Drabowsky vs Sal Maglie | Fifth | 15½ out |
| Monday, September 1 |
| » Defeated Reds (64-68), 1-0 | Sportsman's Park III (34-31) | 62-68 | |
| » Starters: Joe Nuxhall vs Vinegar Bend Mizell | Fifth | 15½ out |
| » Lost to Reds (65-68), 9-3 | Sportsman's Park III (34-32) | 62-69 | |
| » Starters: Brooks Lawrence vs Jim Brosnan | Fifth | 15½ out |
| Tuesday, September 2 |
| » Defeated Reds (65-69), 4-2 | Sportsman's Park III (35-32) | 63-69 | |
| » Starters: Bob Purkey vs Bob Mabe | Fifth | 15 out |
| Wednesday, September 3 |
| » Defeated Cubs (61-73), 9-7 | Wrigley Field (7-3) | 64-69 | Won 2 |
| » Starters: Larry Jackson vs Dick Drott | Fifth | 15 out |
| Thursday, September 4 |
| » Defeated Cubs (61-74), 4-2 | Wrigley Field (8-3) | 65-69 | Won 3 |
| » Starters: Sam Jones vs Dave Hillman | Fifth | 15 out |
| Future Cardinal Rod Booker is born in Los Angeles, CA. Future Cardinal Paul Householder is born in Columbus, OH. |
| Friday, September 5 |
| » Lost to Dodgers (64-71), 2-1 | Sportsman's Park III (35-33) | 65-70 | |
| » Starters: Fred Kipp vs Vinegar Bend Mizell | Fifth | 15 out |
| Saturday, September 6 |
| » Defeated Dodgers (64-72), 3-2 | Sportsman's Park III (36-33) | 66-70 | |
| » Starters: Don Drysdale vs Bob Mabe | Fifth | 14 out |
| Sunday, September 7 |
| » Lost to Dodgers (65-72), 7-5 | Sportsman's Park III (36-34) | 66-71 | |
| » Starters: Johnny Podres vs Larry Jackson | Fifth | 14½ out |
| Tuesday, September 9 |
| » Defeated Cubs (64-75), 8-7 | Sportsman's Park III (37-34) | 67-71 | |
| » Starters: Dave Hillman vs Sam Jones | Fifth | 14½ out |
| Wednesday, September 10 |
| » Defeated Cubs (64-76), 3-1 | Sportsman's Park III (38-34) | 68-71 | Won 2 |
| » Starters: Taylor Phillips vs Vinegar Bend Mizell | Fifth | 14½ out |
| » Major-league debuts: John Buzhardt (Cubs) |
| Thursday, September 11 |
| » Major-league debuts: Jimmie Coker (Phillies) |
| Friday, September 12 |
| » Lost to Braves (84-57), 6-0 | County Stadium (5-5) | 68-72 | |
| » Starters: Bob Mabe vs Lew Burdette | Fifth | 15½ out |
| Saturday, September 13 |
| » Lost to Braves (85-57), 8-2 | County Stadium (5-6) | 68-73 | Lost 2 |
| » Starters: Larry Jackson vs Warren Spahn | Fifth | 16½ out |
| Sunday, September 14 |
| » Defeated Phillies (62-81), 6-3 | Shibe Park (4-6) | 69-73 | |
| » Starters: Sam Jones vs Jack Sanford | Fifth | 15½ out |
| Monday, September 15 |
| » Lost to Phillies (63-81), 6-2 | Shibe Park (4-7) | 69-74 | |
| » Starters: Vinegar Bend Mizell vs Robin Roberts | Fifth | 16½ out |
| Tuesday, September 16 |
| » Lost to Pirates (82-65), 3-1 | Forbes Field (4-7) | 69-75 | Lost 2 |
| » Starters: Bob Mabe vs Ron Kline | Fifth | 17½ out |
| Wednesday, September 17 |
| » Defeated Braves (87-59), 5-3 | Sportsman's Park III (39-34) | 70-75 | |
| » Manager: Stan Hack |
| » Starters: Warren Spahn vs Larry Jackson | Fifth | 16½ out |
| Thursday, September 18 |
| » Lost to Braves (88-59), 9-3 | Sportsman's Park III (39-35) | 70-76 | |
| » Starters: Bob Rush vs Sam Jones | Fifth | 17½ out |
| » Major-league debuts: Ellis Burton (Cardinals) |
| Friday, September 19 |
| » Lost to Giants (76-71), 8-1 | Sportsman's Park III (39-36) | 70-77 | Lost 2 |
| » Starters: Stu Miller vs Vinegar Bend Mizell | Fifth | 17½ out |
| Saturday, September 20 |
| » Lost to Giants (77-71), 5-1 | Sportsman's Park III (39-37) | 70-78 | Lost 3 |
| » Starters: Ruben Gomez vs Bob Mabe | Fifth | 18½ out |
| Sunday, September 21 |
| » Lost to Giants (78-71), 7-4 | Sportsman's Park III (39-38) | 70-79 | Lost 4 |
| » Starters: Johnny Antonelli vs Larry Jackson | Fifth | 19½ out |
| Tuesday, September 23 |
| » Defeated Dodgers (69-81), 5-1 | Los Angeles Memorial Coliseum (4-6) | 71-79 | |
| » Starters: Sam Jones vs Johnny Podres | Fifth | 18½ out |
| Wednesday, September 24 |
| » Lost to Dodgers (70-81), 4-3 | Los Angeles Memorial Coliseum (4-7) | 71-80 | |
| » Starters: Bob Mabe vs Roger Craig | Fifth | 19 out |
| Friday, September 26 |
| » Lost to Giants (79-73), 4-3 | Seals Stadium (2-7) | 71-81 | Lost 2 |
| » Starters: Bill Smith vs Johnny Antonelli | Fifth | 20 out |
| Saturday, September 27 |
| » Defeated Giants (79-74), 11-7 | Seals Stadium (3-7) | 72-81 | |
| » Starters: Larry Jackson vs Mike McCormick | Fi |